<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Q9</accession>
    <name>A0A5F8G3Q9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Protein-glutamine gamma-glutamyltransferase 2</fullName>
            <ecNumber evidence="24">2.3.2.13</ecNumber>
            <ecNumber evidence="27">3.5.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Isopeptidase TGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="33">Protein-glutamine deamidase TGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="32">Protein-glutamine dopaminyltransferase TGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="35">Protein-glutamine histaminyltransferase TGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="36">Protein-glutamine noradrenalinyltransferase TGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="34">Protein-glutamine serotonyltransferase TGM2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Tissue transglutaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Transglutaminase-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="45" type="primary">TGM2</name>
    </gene>
    <organism evidence="45 46">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="45 46" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="45" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="45" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>L-glutaminyl-[protein] + (R)-noradrenaline = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:66560"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:17054"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:72587"/>
            <dbReference type="ChEBI" id="CHEBI:167178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:66561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>L-glutaminyl-[protein] + H2O = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:16442"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:54816"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:14005"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:138370"/>
            <dbReference type="EC" id="2.3.2.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:54817"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>L-glutaminyl-[protein] + dopamine = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:66556"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:17053"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:167175"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:66557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>L-glutaminyl-[protein] + histamine = 5-histaminyl-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:66564"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:17056"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:58432"/>
            <dbReference type="ChEBI" id="CHEBI:167179"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:66565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:66552"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:17052"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:167174"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:66553"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="43">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="43">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="37">Monomer. Interacts with phospholipase C; promoting alpha-1 adrenergic receptor signaling. Interacts with PLCD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Extracellular space</location>
            <location evidence="5">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="24"/>
    <dbReference type="EC" id="3.5.1.44" evidence="27"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3Q9"/>
    <dbReference type="Ensembl" id="ENSMODT00000060704.1">
        <property type="protein sequence ID" value="ENSMODP00000042087.1"/>
        <property type="gene ID" value="ENSMODG00000000203.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244866"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000203">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000001">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF6">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="23" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="18 43" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="20" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 43" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="46" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="44">
        <location>
            <begin position="188"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="42">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="42">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="42">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="43">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="43">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="43">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="43">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00024222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00036377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00036876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00039019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00040561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00041650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00041677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00042099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00042105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00042239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00042912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00043104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00043138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00046685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00047868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00047876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00048230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00048365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="44">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="608" mass="69365" checksum="8FDF8DA66298CA0E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3R2</accession>
    <name>A0A5F8G3R2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CAMK2G</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3R2"/>
    <dbReference type="Ensembl" id="ENSMODT00000078903.1">
        <property type="protein sequence ID" value="ENSMODP00000042118.1"/>
        <property type="gene ID" value="ENSMODG00000000536.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156481"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000536">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14086">
        <property type="entry name" value="STKc_CaMKII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000239">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000001">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000001">
        <property type="entry name" value="calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="54"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="552" mass="61765" checksum="7C3FD4E2F4AEF908" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3S0</accession>
    <name>A0A5F8G3S0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tankyrase 1-binding protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3S0"/>
    <dbReference type="Ensembl" id="ENSMODT00000082657.1">
        <property type="protein sequence ID" value="ENSMODP00000042128.1"/>
        <property type="gene ID" value="ENSMODG00000010377.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154184"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010377">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032764">
        <property type="entry name" value="Tankyrase-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040006">
        <property type="entry name" value="TNKS1BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22042:SF3">
        <property type="entry name" value="RIKEN CDNA 2900026A02 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22042">
        <property type="entry name" value="TANKYRASE 1 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15327">
        <property type="entry name" value="Tankyrase_bdg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01319">
        <property type="entry name" value="Tankyrase_bdg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tankyrase 1-binding protein C-terminal" evidence="2">
        <location>
            <begin position="214"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="394" mass="43916" checksum="8A3C0D5A38514A60" modified="2019-12-11" version="1">MDYLGDKLTVAQSHMTQWMGTVRRSFQEALNLVTTAVAHERTSGEGPGRTPFKRTASFRHFASRSRESFRRFSVRSQQRFSSLRKRQASSEPPDLDQLKQCFARQPPEAKDTDTLVQENDSQYGTWNDPRQSGESFAPESPSPDSNVTSVRKQPPSSRLSSLSSQTEPASPADPGDSSRDQRSTSLDRSSTDLDSTDGTEGAPSSDTAGLEGKVDDFSFINQTSVLDSSALKARAQLSRRNRRRAPISHSLRRSRVGEADNQSSSMEEADSAWMFKDSTEDKLVKKEESDEEEKLPRSERTPVSQPQRLPIFPGVDPSVLKAQLRKRNEVDSPGDGQASAQLSKSPKSPFQPGVLGSRVLPTSMEKEERSEEMSPQWLKDLKSKKRLSQYENQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3S2</accession>
    <name>A0A5F8G3S2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family with sequence similarity 184 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FAM184A</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3S2"/>
    <dbReference type="Ensembl" id="ENSMODT00000058174.1">
        <property type="protein sequence ID" value="ENSMODP00000042081.1"/>
        <property type="gene ID" value="ENSMODG00000017783.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100030210"/>
    <dbReference type="CTD" id="79632"/>
    <dbReference type="GeneTree" id="ENSGT00530000063669"/>
    <dbReference type="OrthoDB" id="75801at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017783">
        <property type="expression patterns" value="Expressed in testis and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039478">
        <property type="entry name" value="FAM184A/B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF7">
        <property type="entry name" value="PROTEIN FAM184A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15665">
        <property type="entry name" value="FAM184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein FAM184A/B N-terminal" evidence="4">
        <location>
            <begin position="56"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="64"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="186"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="311"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="504"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="589"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="717"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="885"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1107" mass="129322" checksum="6BEE536C1EA1FC39" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3S4</accession>
    <name>A0A5F8G3S4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YTH domain-containing family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">YTHDC1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the YTHDF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007496432.1">
        <property type="nucleotide sequence ID" value="XM_007496370.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3S4"/>
    <dbReference type="Ensembl" id="ENSMODT00000084995.1">
        <property type="protein sequence ID" value="ENSMODP00000042133.1"/>
        <property type="gene ID" value="ENSMODG00000020754.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100012426"/>
    <dbReference type="CTD" id="91746"/>
    <dbReference type="GeneTree" id="ENSGT00940000155803"/>
    <dbReference type="OrthoDB" id="5842105at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020754">
        <property type="expression patterns" value="Expressed in ovary and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000002">
        <property type="entry name" value="YTH domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="YTH" evidence="7">
        <location>
            <begin position="311"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="683" mass="79630" checksum="30CC86AF6A56DCE9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3S5</accession>
    <name>A0A5F8G3S5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vir like m6A methyltransferase associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">VIRMA</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vir family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000060193.1">
        <property type="protein sequence ID" value="ENSMODP00000042086.1"/>
        <property type="gene ID" value="ENSMODG00000007320.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002833"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007320">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031801">
        <property type="entry name" value="VIR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026736">
        <property type="entry name" value="Virilizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185:SF0">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15912">
        <property type="entry name" value="VIR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Virilizer N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1474"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1499"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1533"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1598"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1613"/>
            <end position="1622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1622" mass="181649" checksum="6A03EA1FFA7BDEF9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3S6</accession>
    <name>A0A5F8G3S6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Poly(A) RNA polymerase GLD2</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">PAP-associated domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TENT2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with CPEB1, CPEB2, CPSF1 and PABPC1. Interacts with QKI isoform QKI7; promoting recruitment to miRNA miR-122 and miR-122 stabilization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3S6"/>
    <dbReference type="Ensembl" id="ENSMODT00000086755.1">
        <property type="protein sequence ID" value="ENSMODP00000042065.1"/>
        <property type="gene ID" value="ENSMODG00000019716.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156640"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019716">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000007">
        <property type="entry name" value="poly(A) RNA polymerase GLD2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000022">
        <property type="entry name" value="poly(A) RNA polymerase GLD2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="20">
        <location>
            <begin position="175"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="19">
        <location>
            <begin position="402"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="463" mass="52734" checksum="F7767CBF387C4181" modified="2019-12-11" version="1">MFPNSSNLGRPPFHPKFQQPSNFFKLPLNLSPTLSHQQIVDAQFNCQNVDLPRTLLSGNLSPIPTQSLSYGNGSPIRTSTSTSPVFRGRKRLSNEQNVPLDVKRQRFHSPYHESTVANQTVPLPDERRYSAPGSVTPPLLHVNYAPDLVRSVPPFREAPFLEPREITLPVAKDKLSQQVLDLFQVCQQQSCDLKKKELCRTQLQREIQLIFPHSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPVNQKTEARHILSLVQKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNIVGIRNTFLLRTYAYLESRVRPLVLVVKKWASHHEINDASRGTLNSYSLVLMVLHYLQTLPEPILPSLQKNYPDSFSPSMQLHLVHQAPCSIPPYLSKNGSALGDLLLGFLKYYATEFDWNSQMISVREAKAIPRPDGIEWRNKFICVEVYSDFSPAFTHLEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3S8</accession>
    <name>A0A5F8G3S8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trans-golgi network protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3S8"/>
    <dbReference type="Ensembl" id="ENSMODT00000088897.1">
        <property type="protein sequence ID" value="ENSMODP00000042124.1"/>
        <property type="gene ID" value="ENSMODG00000038085.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064712"/>
    <dbReference type="OMA" id="EDQPKGT"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000038085">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23211:SF0">
        <property type="entry name" value="TRANS-GOLGI NETWORK INTEGRAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23211">
        <property type="entry name" value="TRANS-GOLGI NETWORK INTEGRAL MEMBRANE PROTEIN TGN38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17818">
        <property type="entry name" value="KCT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="54791" checksum="92EA455832D4D436" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3T0</accession>
    <name>A0A5F8G3T0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrosomal protein 131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CEP131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3T0"/>
    <dbReference type="Ensembl" id="ENSMODT00000082766.1">
        <property type="protein sequence ID" value="ENSMODP00000042091.1"/>
        <property type="gene ID" value="ENSMODG00000002589.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001758"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002589">
        <property type="expression patterns" value="Expressed in ovary and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030465">
        <property type="entry name" value="CEP131"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31540">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 131 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31540:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 131 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="574"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="704"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="866"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1056" mass="121293" checksum="B3D77316D28EA1AF" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G422</accession>
    <name>A0A5F8G422_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Centrosomal protein 192</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CEP192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000053385.1">
        <property type="protein sequence ID" value="ENSMODP00000042217.1"/>
        <property type="gene ID" value="ENSMODG00000021418.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048187"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021418">
        <property type="expression patterns" value="Expressed in hindlimb bud and 22 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051298">
        <property type="term" value="P:centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090222">
        <property type="term" value="P:centrosome-templated microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21856">
        <property type="entry name" value="Plk4BD_Cep192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054085">
        <property type="entry name" value="Cep192-like_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054086">
        <property type="entry name" value="Cep192-like_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054089">
        <property type="entry name" value="Cep192-like_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054091">
        <property type="entry name" value="Cep192-like_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054092">
        <property type="entry name" value="Cep192-like_D6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054087">
        <property type="entry name" value="Cep192-like_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054088">
        <property type="entry name" value="Cep192-like_D8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057662">
        <property type="entry name" value="CEP192_Aurora-A_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057665">
        <property type="entry name" value="CEP192_PLK4_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054090">
        <property type="entry name" value="Cep192_Spd-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039103">
        <property type="entry name" value="Spd-2/CEP192"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16029">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 192 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16029:SF11">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 192 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25763">
        <property type="entry name" value="Aurora-A_bind_CEP192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22060">
        <property type="entry name" value="Cep192_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22064">
        <property type="entry name" value="Cep192_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22067">
        <property type="entry name" value="Cep192_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22073">
        <property type="entry name" value="Cep192_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22074">
        <property type="entry name" value="Cep192_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22076">
        <property type="entry name" value="Cep192_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22065">
        <property type="entry name" value="Cep192_D7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22066">
        <property type="entry name" value="Cep192_D8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25765">
        <property type="entry name" value="PLK4_bind_CEP192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep192-like" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="3">
        <location>
            <begin position="1302"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="6">
        <location>
            <begin position="1458"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192/Spd-2-like" evidence="7">
        <location>
            <begin position="1576"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="8">
        <location>
            <begin position="1699"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="9">
        <location>
            <begin position="1938"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="4">
        <location>
            <begin position="2074"/>
            <end position="2195"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="5">
        <location>
            <begin position="2245"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2340" mass="260437" checksum="9FE63432B68187D7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G430</accession>
    <name>A0A5F8G430_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pleckstrin homology like domain family B member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PHLDB2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000076668.1">
        <property type="protein sequence ID" value="ENSMODP00000042222.1"/>
        <property type="gene ID" value="ENSMODG00000018090.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100010359"/>
    <dbReference type="CTD" id="90102"/>
    <dbReference type="GeneTree" id="ENSGT00940000156371"/>
    <dbReference type="OrthoDB" id="6020705at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018090">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd14673">
        <property type="entry name" value="PH_PHLDB1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000006">
        <property type="entry name" value="Pleckstrin homology like domain family B member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052212">
        <property type="entry name" value="PH-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037810">
        <property type="entry name" value="PHLDB1/2/3_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156:SF21">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="841"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="925"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="586"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="721"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="929"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="940"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1314" mass="148807" checksum="5C6D4B58014B2269" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G433</accession>
    <name>A0A5F8G433_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tonsoku-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Inhibitor of kappa B-related protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NF-kappa-B inhibitor-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">TONSL</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones. Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2. Interacts with the MCM complex, the FACT complex and the RPA complex. Interacts with MCM5; the interaction is direct. Binds histones, with a strong preference for histone H3.1 (histones H3.1 and H3-4/H3.1t). Interacts (via ANK repeats) with histone H4; specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0). May interact with DNAJC9; the interaction seems to be histone-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Tonsoku family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000056712.1">
        <property type="protein sequence ID" value="ENSMODP00000042227.1"/>
        <property type="gene ID" value="ENSMODG00000010893.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160188"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010893">
        <property type="expression patterns" value="Expressed in hindlimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000151">
        <property type="entry name" value="Tonsoku like, DNA repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000297">
        <property type="entry name" value="tonsoku-like protein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358:SF1">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 23" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="23">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="23">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="22">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="22">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="22">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="448"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="794"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="472"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="834"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00053445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00063527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00080944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1317" mass="146485" checksum="8B1669BA8D194839" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G435</accession>
    <name>A0A5F8G435_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transport and golgi organization 6 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TANGO6</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056667216.1">
        <property type="nucleotide sequence ID" value="XM_056811238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G435"/>
    <dbReference type="Ensembl" id="ENSMODT00000052434.1">
        <property type="protein sequence ID" value="ENSMODP00000042190.1"/>
        <property type="gene ID" value="ENSMODG00000003215.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100027823"/>
    <dbReference type="CTD" id="79613"/>
    <dbReference type="GeneTree" id="ENSGT00390000010938"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003215">
        <property type="expression patterns" value="Expressed in liver and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000429">
        <property type="entry name" value="Transport and golgi organization 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057407">
        <property type="entry name" value="HEAT_TANGO6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057347">
        <property type="entry name" value="TANGO6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23565">
        <property type="entry name" value="ARM_TANGO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25267">
        <property type="entry name" value="TANGO6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TANGO6 N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="TANGO6 HEAT repeat" evidence="4">
        <location>
            <begin position="310"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="847"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="762"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1051" mass="114936" checksum="3CBB88DB6EAC36C5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G436</accession>
    <name>A0A5F8G436_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nuclear pore complex protein Nup153</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">153 kDa nucleoporin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Nucleoporin Nup153</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">NUP153</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the NUP153 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000070772.1">
        <property type="protein sequence ID" value="ENSMODP00000042213.1"/>
        <property type="gene ID" value="ENSMODG00000010951.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153253"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010951">
        <property type="expression patterns" value="Expressed in spermatid and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042405">
        <property type="term" value="C:nuclear inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup153"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000015">
        <property type="entry name" value="Nuclear pore complex protein Nup153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013913">
        <property type="entry name" value="Nup153_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018892">
        <property type="entry name" value="Retro-transposon_transp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF23">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08604">
        <property type="entry name" value="Nup153"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10599">
        <property type="entry name" value="Nup_retrotrp_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="15" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="25">
        <location>
            <begin position="545"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="25">
        <location>
            <begin position="611"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="25">
        <location>
            <begin position="682"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="25">
        <location>
            <begin position="740"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="851"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1214"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="868"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1222"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1243"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1262"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00079437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1374" mass="143238" checksum="83C6F577DFD0317D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G438</accession>
    <name>A0A5F8G438_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycolipid transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GLTP</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLTP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G438"/>
    <dbReference type="Ensembl" id="ENSMODT00000061056.1">
        <property type="protein sequence ID" value="ENSMODP00000042195.1"/>
        <property type="gene ID" value="ENSMODG00000004397.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155182"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004397">
        <property type="expression patterns" value="Expressed in placenta and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120013">
        <property type="term" value="F:lipid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000003">
        <property type="entry name" value="glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF97">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="9">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="191" mass="21782" checksum="F3B85FEBDC669396" modified="2019-12-11" version="1">MARVGASQGLPLTRSSDCFGSPIFTPIKADISGNIKTIRAVYDTDPTKFRTLQNILEAEKEMYGAEWPKVGATLALMWLKRGLRFIQVLLQSICDGERDENRPNLIRVNVTKAYEMALKKYHGWLVQKIFQGALYAAPYKSDFLKALSKGQDIPEEECLEKIRLFLVNFTATIDVIYEMYTKMNAELNYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G439</accession>
    <name>A0A5F8G439_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 186</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G439"/>
    <dbReference type="Ensembl" id="ENSMODT00000073042.1">
        <property type="protein sequence ID" value="ENSMODP00000042218.1"/>
        <property type="gene ID" value="ENSMODG00000009821.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00720000108851"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009821">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 22 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038830">
        <property type="entry name" value="CCDC186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911">
        <property type="entry name" value="CTCL TUMOR ANTIGEN HD-CL-01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="703"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="836" mass="96344" checksum="203716B49A783D99" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G440</accession>
    <name>A0A5F8G440_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G440"/>
    <dbReference type="Ensembl" id="ENSMODT00000076805.1">
        <property type="protein sequence ID" value="ENSMODP00000042209.1"/>
        <property type="gene ID" value="ENSMODG00000040423.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162258"/>
    <dbReference type="OMA" id="GVHWGGR"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000040423">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000023">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000078">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF80">
        <property type="entry name" value="GALECTIN-9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="173"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="301" mass="33906" checksum="10638A2DBE171175" modified="2019-12-11" version="1">VTVNGAVLRSGTNRFSVNFQCGFDGNNIAFHFNPRFDGGSYVVCNTKHSGSWGPEERKMQMPFTKGMPFEIRFQLQNEAFSVIVNGNYFLRYEHRMAFQKVDTIAIEGMVMVSFIRFQVRMDGTGLFHCPISCHRGWLHFPVSSLPLELPSAPPSSVPYLRVHPACLSPPLPFRTSISGGLYPNRIILVSGSILPTANRFEINLKCGNDIAFHLNPRFCENAVVRNTQINRSWGSEERGLPGCMPFARGQSFMVCIRCDVPCLKVTVNGCHQFDYKHRIRNLLSINQLEVSGDIQLTQVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G441</accession>
    <name>A0A5F8G441_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="15">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FKBP15</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with WIP and actin. Interacts with TBC1D23.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G441"/>
    <dbReference type="Ensembl" id="ENSMODT00000060767.1">
        <property type="protein sequence ID" value="ENSMODP00000042232.1"/>
        <property type="gene ID" value="ENSMODG00000004548.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064286"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004548">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000020">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056598">
        <property type="entry name" value="FKBP-15_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927:SF1">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23649">
        <property type="entry name" value="FKBP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="18">
        <location>
            <begin position="123"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="219"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="664"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="891"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1029"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="491"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="750"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="666"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="968"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="980"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1081"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1109"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1159"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1171" mass="130291" checksum="196EC7EC910E3C27" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G442</accession>
    <name>A0A5F8G442_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Discs large MAGUK scaffold protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G442"/>
    <dbReference type="Ensembl" id="ENSMODT00000083693.1">
        <property type="protein sequence ID" value="ENSMODP00000042226.1"/>
        <property type="gene ID" value="ENSMODG00000020512.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159409"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020512">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06723">
        <property type="entry name" value="PDZ1_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06724">
        <property type="entry name" value="PDZ2_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06795">
        <property type="entry name" value="PDZ3_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12031">
        <property type="entry name" value="SH3_DLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000008">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000001">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000001">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000058">
        <property type="entry name" value="Disks large homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000049">
        <property type="entry name" value="disks large homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000002">
        <property type="entry name" value="Disks large homolog 4 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019583">
        <property type="entry name" value="DLG1-4_PDZ_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016313">
        <property type="entry name" value="DLG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019590">
        <property type="entry name" value="DLG1_PEST_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF5">
        <property type="entry name" value="DISKS LARGE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10608">
        <property type="entry name" value="MAGUK_N_PEST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10600">
        <property type="entry name" value="PDZ_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001741">
        <property type="entry name" value="MAGUK_DLGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01277">
        <property type="entry name" value="MAGUK_N_PEST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="176"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="271"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="418"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="533"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="679"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="797" mass="87115" checksum="C3241F36F303CED4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G443</accession>
    <name>A0A5F8G443_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">THAP domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">THAP1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
            <location evidence="1 14">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the THAP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G443"/>
    <dbReference type="Ensembl" id="ENSMODT00000061276.1">
        <property type="protein sequence ID" value="ENSMODP00000042214.1"/>
        <property type="gene ID" value="ENSMODG00000010093.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159383"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010093">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001935">
        <property type="term" value="P:endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 13 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="16">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="131"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="202" mass="23532" checksum="3409E1C8A12FAFE1" modified="2019-12-11" version="1">ADNCEVTGPQSYRFPLTRPDLCKKWEAAVRRKNFKPSKYSSICSEHFTPDCFKRECNNKLLKENAVPTIFCFTEPHDKNEDLLEQQEQLPPPPLTPPVSQVDAALGLLMPPLHTPNNLAVFCDHNYTVEDTVHQRKRIQQLEEQVEKLRKKLKTAQQRCRRQERQLEKLKEVVQFQKEKDALSGRGYVILPNDYYEIVEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G444</accession>
    <name>A0A5F8G444_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">FYVE, RhoGEF and PH domain containing 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G444"/>
    <dbReference type="Ensembl" id="ENSMODT00000068712.1">
        <property type="protein sequence ID" value="ENSMODP00000042223.1"/>
        <property type="gene ID" value="ENSMODG00000014333.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159597"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014333">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15740">
        <property type="entry name" value="FYVE_FGD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13236">
        <property type="entry name" value="PH2_FGD1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000013">
        <property type="entry name" value="FYVE, RhoGEF and PH domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035941">
        <property type="entry name" value="FGD1-4_PH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF14">
        <property type="entry name" value="FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="13">
        <location>
            <begin position="170"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="383"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="537"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="620"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="79843" checksum="238D3452467484D7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G445</accession>
    <name>A0A5F8G445_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional activator Myb</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MYB</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G445"/>
    <dbReference type="Ensembl" id="ENSMODT00000065203.1">
        <property type="protein sequence ID" value="ENSMODP00000042200.1"/>
        <property type="gene ID" value="ENSMODG00000017488.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156248"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017488">
        <property type="expression patterns" value="Expressed in ovary and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000042">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015395">
        <property type="entry name" value="C-myb_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012642">
        <property type="entry name" value="Tscrpt_reg_Wos2-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09316">
        <property type="entry name" value="Cmyb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07988">
        <property type="entry name" value="LMSTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="97"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="149"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="153"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="620" mass="70569" checksum="7697A5B78D412791" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G448</accession>
    <name>A0A5F8G448_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G448"/>
    <dbReference type="Ensembl" id="ENSMODT00000077332.1">
        <property type="protein sequence ID" value="ENSMODP00000042219.1"/>
        <property type="gene ID" value="ENSMODG00000015511.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153661"/>
    <dbReference type="OMA" id="MFAIIRE"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015511">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050657">
        <property type="entry name" value="Ankyrin_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24147:SF53">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24147">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="329" mass="36116" checksum="A0C1643F317E6B91" modified="2019-12-11" version="1">GQTCRDSGIDGAVAAKGYRLQDKELGKLHKAASIGDIAKVQRLLRKNDPNEPDKLNRTPLHIACASGYPDVVSLLVERNCKLNLCDGDNRTPLIKAVQCQQEECATILLSHGADPNVVDTRSNTALHYSALGHNRAIAAKLVEHKGDIEAKNQEGYTPLLLAITEHNKEMVDFFLKNGANVNACDNSKRTALMIAVSTEPTSIVNLLLQFDIDLSLQDNYGWTAEEYALVSGFPVHRELILQYGQRQLNQLTSAKISSPDRASDTVFTLGGPALDKEDIKEEKKAQGLGGPGNRKAGTLFMETRRKPGRRGLFKWSYLSFVLCPFISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G449</accession>
    <name>A0A5F8G449_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UTP20 small subunit processome component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UTP20</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000067696.1">
        <property type="protein sequence ID" value="ENSMODP00000042237.1"/>
        <property type="gene ID" value="ENSMODG00000003141.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016813"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003141">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001599">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="903"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1805"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2372"/>
            <end position="2739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1714"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2567"/>
            <end position="2589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2569"/>
            <end position="2579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2580"/>
            <end position="2589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2762" mass="314974" checksum="4CF70FA5C60E9C8E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G450</accession>
    <name>A0A5F8G450_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ral guanine nucleotide dissociation stimulator like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RGL2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G450"/>
    <dbReference type="Ensembl" id="ENSMODT00000067100.1">
        <property type="protein sequence ID" value="ENSMODP00000042205.1"/>
        <property type="gene ID" value="ENSMODG00000014185.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161403"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014185">
        <property type="expression patterns" value="Expressed in endometrium and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17211">
        <property type="entry name" value="RA_RGL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF367">
        <property type="entry name" value="RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="86"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="241"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="643"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="730"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="773" mass="83772" checksum="9796BC7C11DCFD41" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G451</accession>
    <name>A0A5F8G451_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">E3 ubiquitin-protein ligase RNF213</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">E3 ubiquitin-lipopolysaccharide ligase RNF213</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Mysterin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">RING finger protein 213</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">RNF213</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Monomer. Interacts with UBE2L3/UBCH7; UBE2L3/UBCH7 is the most efficient ubiquitin-conjugating enzyme E2 for the ubiquitin ligase activity. Interacts with UBE2N/UBC13; promoting 'Lys-63'-linked ubiquitination of target proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="Ensembl" id="ENSMODT00000056737.1">
        <property type="protein sequence ID" value="ENSMODP00000042236.1"/>
        <property type="gene ID" value="ENSMODG00000002357.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00630000089884"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002357">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120323">
        <property type="term" value="P:lipid ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16561">
        <property type="entry name" value="RING-HC_RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000488">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000491">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000804">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 27" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="28">
        <location>
            <begin position="3484"/>
            <end position="3522"/>
        </location>
    </feature>
    <feature type="domain" description="RZ-type" evidence="29">
        <location>
            <begin position="3945"/>
            <end position="4017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00064239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00079225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00079490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00080635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="4665" mass="536267" checksum="4A5FA6559AE8E251" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G452</accession>
    <name>A0A5F8G452_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TANC2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Postsynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TANC family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000085530.1">
        <property type="protein sequence ID" value="ENSMODP00000042233.1"/>
        <property type="gene ID" value="ENSMODG00000010102.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156447"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010102">
        <property type="expression patterns" value="Expressed in cerebellum and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000022">
        <property type="entry name" value="protein TANC2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000036">
        <property type="entry name" value="protein TANC2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000044">
        <property type="entry name" value="Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058018">
        <property type="entry name" value="AAA_lid_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058056">
        <property type="entry name" value="WH_TANC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF21">
        <property type="entry name" value="PROTEIN TANC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25520">
        <property type="entry name" value="AAA_lid_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25521">
        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 9" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="TANC1/2-like AAA+ ATPase lid" evidence="12">
        <location>
            <begin position="648"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="TANC1/2-like winged helix" evidence="13">
        <location>
            <begin position="744"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="967"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1116"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1149"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1182"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1215"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1304"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1351"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1385"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="446"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1489"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1837"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2021"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1418"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1523"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1607"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1837"/>
            <end position="1852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2044" mass="225902" checksum="918369CFE2FADC67" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUT3</accession>
    <name>A0A5F8GUT3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ANO3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056657980.1">
        <property type="nucleotide sequence ID" value="XM_056802002.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056657981.1">
        <property type="nucleotide sequence ID" value="XM_056802003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUT3"/>
    <dbReference type="Ensembl" id="ENSMODT00000078782.1">
        <property type="protein sequence ID" value="ENSMODP00000051305.1"/>
        <property type="gene ID" value="ENSMODG00000009376.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100030721"/>
    <dbReference type="CTD" id="63982"/>
    <dbReference type="GeneTree" id="ENSGT00940000156257"/>
    <dbReference type="OMA" id="TMGRNMR"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009376">
        <property type="expression patterns" value="Expressed in cerebellum and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF16">
        <property type="entry name" value="ANOCTAMIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="780"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="881"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="127"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="355"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="952" mass="112143" checksum="D6B31D6DB572A78B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUT4</accession>
    <name>A0A5F8GUT4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tubulin polyglutamylase complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TPGS2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007486793.1">
        <property type="nucleotide sequence ID" value="XM_007486731.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUT4"/>
    <dbReference type="Ensembl" id="ENSMODT00000085847.1">
        <property type="protein sequence ID" value="ENSMODP00000051119.1"/>
        <property type="gene ID" value="ENSMODG00000000317.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013227"/>
    <dbReference type="CTD" id="25941"/>
    <dbReference type="GeneTree" id="ENSGT00390000018344"/>
    <dbReference type="OrthoDB" id="10249691at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000317">
        <property type="expression patterns" value="Expressed in spermatocyte and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039231">
        <property type="entry name" value="TPGS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31854">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31854:SF2">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="295" mass="33349" checksum="B7D35EB70E51ABFE" modified="2019-12-11" version="1">MEDRSLQCLGGNKPHLEKLTLGVARILEASPGVTGVSVVEREPADIGMITAWEQENDCILPDDLRNFYLMTNGFHMLWNVKLDNYPVPLGSLMINSLMKLNQLHQSSVYLLPNSPSLGDLEEDEDEVFVPNGDDPEKPHFDSRNRIFELDSCSGNGKVCLVYKRDKPAPQDSEIWFLDRALYWHFLSDSFTTYYRLLITHLGLPQWQYAFTSYGISPQAKQWFNMYKPITYNTAVLAEDDGIFMNKLDPSKVFKSKSKTLVSKKRSSLQSSSSQRGSSASPVIKSSPIPGNSIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUT9</accession>
    <name>A0A5F8GUT9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromodomain Y-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CDYL2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts (via chromo domain) with histone H3K9me3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056651534.1">
        <property type="nucleotide sequence ID" value="XM_056795556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUT9"/>
    <dbReference type="FunCoup" id="A0A5F8GUT9">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051124"/>
    <dbReference type="Ensembl" id="ENSMODT00000085868.1">
        <property type="protein sequence ID" value="ENSMODP00000051124.1"/>
        <property type="gene ID" value="ENSMODG00000008202.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100012542"/>
    <dbReference type="CTD" id="124359"/>
    <dbReference type="GeneTree" id="ENSGT00940000159646"/>
    <dbReference type="InParanoid" id="A0A5F8GUT9"/>
    <dbReference type="OMA" id="QASTPKF"/>
    <dbReference type="OrthoDB" id="6357915at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008202">
        <property type="expression patterns" value="Expressed in spermatid and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18634">
        <property type="entry name" value="CD_CDY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000018">
        <property type="entry name" value="Chromodomain Y like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000012">
        <property type="entry name" value="Chromodomain Y-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF2">
        <property type="entry name" value="CHROMODOMAIN Y-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="6">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00063797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="556" mass="62033" checksum="867B430CBA14711F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUU2</accession>
    <name>A0A5F8GUU2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-mannosidase</fullName>
            <ecNumber evidence="5">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mannanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MANBA</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUU2"/>
    <dbReference type="Ensembl" id="ENSMODT00000061138.1">
        <property type="protein sequence ID" value="ENSMODP00000051315.1"/>
        <property type="gene ID" value="ENSMODG00000020669.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001670"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020669">
        <property type="expression patterns" value="Expressed in placenta and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000650">
        <property type="entry name" value="Mannosidase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002234">
        <property type="entry name" value="Mannosidase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000060">
        <property type="entry name" value="Probable beta-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023920700" description="beta-mannosidase" evidence="13">
        <location>
            <begin position="33"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="16">
        <location>
            <begin position="45"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="15">
        <location>
            <begin position="662"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="14">
        <location>
            <begin position="759"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="839" mass="95265" checksum="1DF383D705DE00C6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUU3</accession>
    <name>A0A5F8GUU3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="Ensembl" id="ENSMODT00000088566.1">
        <property type="protein sequence ID" value="ENSMODP00000051129.1"/>
        <property type="gene ID" value="ENSMODG00000002145.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155705"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002145">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23074">
        <property type="entry name" value="PDZ_MAST2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000008">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF136">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="336"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="674"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="14">
        <location>
            <begin position="857"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="166"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="748"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="820"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="947"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="762"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="957"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="993"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1100"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1144"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1210"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1230"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1286"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1304" mass="140444" checksum="F3966F61C35F0B43" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUU4</accession>
    <name>A0A5F8GUU4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000059387.1">
        <property type="protein sequence ID" value="ENSMODP00000051272.1"/>
        <property type="gene ID" value="ENSMODG00000041553.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162673"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000041553">
        <property type="expression patterns" value="Expressed in liver and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000436">
        <property type="entry name" value="ATP binding cassette subfamily A member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF274">
        <property type="entry name" value="ABC-TYPE ORGANIC ANION TRANSPORTER ABCA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1028"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="440"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1162"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1502" mass="171415" checksum="B515F73B2E29F205" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUU6</accession>
    <name>A0A5F8GUU6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Adhesion G protein-coupled receptor E5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ADGRE5</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUU6"/>
    <dbReference type="Ensembl" id="ENSMODT00000081047.1">
        <property type="protein sequence ID" value="ENSMODP00000050981.1"/>
        <property type="gene ID" value="ENSMODG00000002432.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160578"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002432">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000177">
        <property type="entry name" value="Adhesion G protein-coupled receptor E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000136">
        <property type="entry name" value="Adhesion G protein-coupled receptor E5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000007">
        <property type="entry name" value="Adhesion G protein-coupled receptor E5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000002">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003056">
        <property type="entry name" value="GPCR_2_ADGRE2_ADGRE5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF348">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR E5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01278">
        <property type="entry name" value="CD97PROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023865796" evidence="15">
        <location>
            <begin position="24"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="17">
        <location>
            <begin position="294"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="18">
        <location>
            <begin position="487"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="777" mass="85502" checksum="3E5A4E55C13582FD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUU8</accession>
    <name>A0A5F8GUU8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Caspase-3</fullName>
            <ecNumber evidence="15">3.4.22.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC654275</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.</text>
            <dbReference type="EC" id="3.4.22.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.56" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUU8"/>
    <dbReference type="Ensembl" id="ENSMODT00000078935.1">
        <property type="protein sequence ID" value="ENSMODP00000051277.1"/>
        <property type="gene ID" value="ENSMODG00000051240.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153232"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000051240">
        <property type="expression patterns" value="Expressed in forelimb bud and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097194">
        <property type="term" value="P:execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1470:FF:000002">
        <property type="entry name" value="Caspase-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000001">
        <property type="entry name" value="Caspase-3 preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF198">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="19">
        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="18">
        <location>
            <begin position="167"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="261" mass="29684" checksum="0A4301A76FA77E7F" modified="2019-12-11" version="1">FILKSLHSSKSVESGLSSDSYKMDYPEMGLCVIINNTHFHNDTELSPRTGSDKDAANLIDIFRSLKYEVRNKNNLTRDKMIELLRQVSEEDHSQRSSFVCVILSHGEEGVIFGTDDSVELKELTYFFKGYKCKSLTGKPKLFIIQACQGREFDCGVETDSGTDEDVACHKIPVEADFLYAYSTVPGYYSLRDPKDGSWFIQALCAVLKQHAHKLEIMQILTRVNRKVATEFESYSSKASLHAKKQMPCIMSMLTKELYFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUV1</accession>
    <name>A0A5F8GUV1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Solute carrier family 22 member 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SLC22A12</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUV1"/>
    <dbReference type="Ensembl" id="ENSMODT00000070050.1">
        <property type="protein sequence ID" value="ENSMODP00000051139.1"/>
        <property type="gene ID" value="ENSMODG00000051385.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162485"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000051385">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="528" mass="57928" checksum="13622AA434C1818D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUV2</accession>
    <name>A0A5F8GUV2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spectrin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SPTBN4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000072524.1">
        <property type="protein sequence ID" value="ENSMODP00000050986.1"/>
        <property type="gene ID" value="ENSMODG00000007773.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156343"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007773">
        <property type="expression patterns" value="Expressed in cerebellum and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008091">
        <property type="term" value="C:spectrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000018">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000033">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000294">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016343">
        <property type="entry name" value="Spectrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002297">
        <property type="entry name" value="Spectrin_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="69"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="188"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="2138"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1569"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1873"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1929"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2250"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1267"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1380"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1873"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1948"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1966"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2014"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2063"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2084"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2144"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2255"/>
            <end position="2268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2286" mass="258084" checksum="517584A0AB2BA08D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUV3</accession>
    <name>A0A5F8GUV3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OSBPL9</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Interacts with OSBPL11 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:81667"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer with OSBPL11. Interacts with OSBPL10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007480242.1">
        <property type="nucleotide sequence ID" value="XM_007480180.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUV3"/>
    <dbReference type="FunCoup" id="A0A5F8GUV3">
        <property type="interactions" value="3008"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051282"/>
    <dbReference type="Ensembl" id="ENSMODT00000061932.1">
        <property type="protein sequence ID" value="ENSMODP00000051282.1"/>
        <property type="gene ID" value="ENSMODG00000000934.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100011138"/>
    <dbReference type="CTD" id="114883"/>
    <dbReference type="GeneTree" id="ENSGT00940000154690"/>
    <dbReference type="InParanoid" id="A0A5F8GUV3"/>
    <dbReference type="OMA" id="CTIEQKQ"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000934">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13290">
        <property type="entry name" value="PH_ORP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000089">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000002">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF200">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="234"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="759" mass="85691" checksum="DC83DDE7F218D072" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUV7</accession>
    <name>A0A5F8GUV7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Lin-28 homolog B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LIN28B</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007484439.1">
        <property type="nucleotide sequence ID" value="XM_007484377.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUV7"/>
    <dbReference type="Ensembl" id="ENSMODT00000054378.1">
        <property type="protein sequence ID" value="ENSMODP00000051418.1"/>
        <property type="gene ID" value="ENSMODG00000018035.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100028142"/>
    <dbReference type="CTD" id="389421"/>
    <dbReference type="GeneTree" id="ENSGT00940000153295"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018035">
        <property type="expression patterns" value="Expressed in forelimb bud and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010587">
        <property type="term" value="P:miRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060964">
        <property type="term" value="P:regulation of miRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000007">
        <property type="entry name" value="Protein lin-28 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000087">
        <property type="entry name" value="Protein lin-28 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051373">
        <property type="entry name" value="Lin-28_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054081">
        <property type="entry name" value="Lin-28A-like_Znf-CCHC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109">
        <property type="entry name" value="PROTEIN LIN-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109:SF3">
        <property type="entry name" value="PROTEIN LIN-28 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21890">
        <property type="entry name" value="Lin-28A-like_zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CSD" evidence="13">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="259" mass="28501" checksum="1505592ECE1BF66A" modified="2019-12-11" version="1">MMRSFQKVSSSPGGASKGGGDEPGKLQEQEEEESQVLHGTGHCKWFNVRMGFGFISMINREGSPLDIPVDVFVHQSKLYMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGNPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIMHMVANCPHKTVPQPPTSSQGRHEAEPQPSTSTFPREVAGAYGYSSPSYSQEGRSEISERSGRSPQETSSSKLSTSPEEQSRKGPSVQKRKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUV8</accession>
    <name>A0A5F8GUV8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Phosphatidylinositol-binding clathrin assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PICALM</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Binds to clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate. Interacts with PIMREG; this interaction may change the subcellular location into the nucleus. Interacts with AP2A1 (via its alpha-appendage domain). Interacts (via N-terminus) with VAMP2; VAMP3; VAMP7 and VAMP8 (Via N-terminus). Interacts with LC3/MAP1LC3A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <location evidence="5">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PICALM/SNAP91 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUV8"/>
    <dbReference type="Ensembl" id="ENSMODT00000055954.1">
        <property type="protein sequence ID" value="ENSMODP00000051144.1"/>
        <property type="gene ID" value="ENSMODG00000004297.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183068"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004297">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16985">
        <property type="entry name" value="ANTH_N_AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000001">
        <property type="entry name" value="phosphatidylinositol-binding clathrin assembly protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000001">
        <property type="entry name" value="phosphatidylinositol-binding clathrin assembly protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0168">Coated pit</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="23">
        <location>
            <begin position="63"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="731" mass="78923" checksum="17E3727DA1BA7CF0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUV9</accession>
    <name>A0A5F8GUV9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">6-phosphofructokinase type B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphofructo-1-kinase isozyme B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PFKL</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUV9"/>
    <dbReference type="Ensembl" id="ENSMODT00000059949.1">
        <property type="protein sequence ID" value="ENSMODP00000051287.1"/>
        <property type="gene ID" value="ENSMODG00000003119.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159292"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003119">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000001">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000003">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF14">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="20">
        <location>
            <begin position="116"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="20">
        <location>
            <begin position="369"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="735" mass="80201" checksum="FF6C353B29C578DE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUW1</accession>
    <name>A0A5F8GUW1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial outer membrane protein SLC25A46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Solute carrier family 25 member 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC25A46</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization. May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane. Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex. May associate with the endoplasmic reticulum membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016286847.1">
        <property type="nucleotide sequence ID" value="XM_016431361.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUW1"/>
    <dbReference type="Ensembl" id="ENSMODT00000072605.1">
        <property type="protein sequence ID" value="ENSMODP00000051292.1"/>
        <property type="gene ID" value="ENSMODG00000015644.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100012827"/>
    <dbReference type="CTD" id="91137"/>
    <dbReference type="GeneTree" id="ENSGT00390000015874"/>
    <dbReference type="OrthoDB" id="2403262at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015644">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000057">
        <property type="entry name" value="Solute carrier family 25 member 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039158">
        <property type="entry name" value="SLC25A46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252:SF2">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252">
        <property type="entry name" value="TB1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="220"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="327" mass="36599" checksum="3E27FD6BF16B0589" modified="2019-12-11" version="1">MKTEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHARHYHLTPFTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGIISEFTPLPRELSHKWSPKQVGEHLLLKALTYVVAMPFYSASLIETVQSEIIRDNAGILECVKEGIGRVIGLGVPHSKRLLPLLALTFPTVLHGVLHYIISSIIQKFVLLLLKRKNTHNHPTESTSPVQSILDAYFPELIANFTASLCSDVMLYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIKQEEGMLGFYKGFGAIIVQYALHAAVLQITKIIYSTLLQSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUW2</accession>
    <name>A0A5F8GUW2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Laminin subunit beta 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000061760.1">
        <property type="protein sequence ID" value="ENSMODP00000050996.1"/>
        <property type="gene ID" value="ENSMODG00000039230.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156060"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000039230">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043256">
        <property type="term" value="C:laminin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000074">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000084">
        <property type="entry name" value="Laminin subunit alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000065">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000130">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000145">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000004">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000010">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000135">
        <property type="entry name" value="Laminin subunit beta 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000001">
        <property type="entry name" value="Laminin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013015">
        <property type="entry name" value="Laminin_IV_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF197">
        <property type="entry name" value="LAMININ SUBUNIT BETA-1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21199">
        <property type="entry name" value="LAMININ_IV_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51116">
        <property type="entry name" value="LAMININ_IVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin N-terminal" evidence="16">
        <location>
            <begin position="45"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="406"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="466"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type B" evidence="15">
        <location>
            <begin position="557"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="771"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="818"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="864"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="914"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="977"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="1030"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="1088"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="1136"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="773"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1013"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1088"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1090"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1109"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1136"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1138"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1157"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1372" mass="148325" checksum="038E50ECA0FF08A7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV53</accession>
    <name>A0A5F8GV53_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myotubularin related protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV53"/>
    <dbReference type="FunCoup" id="A0A5F8GV53">
        <property type="interactions" value="1769"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051249"/>
    <dbReference type="Ensembl" id="ENSMODT00000053913.1">
        <property type="protein sequence ID" value="ENSMODP00000051249.1"/>
        <property type="gene ID" value="ENSMODG00000009082.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100030849"/>
    <dbReference type="KEGG" id="mdo:100030849"/>
    <dbReference type="GeneTree" id="ENSGT00940000157272"/>
    <dbReference type="InParanoid" id="A0A5F8GV53"/>
    <dbReference type="OMA" id="FNEAFLX"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009082">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13341">
        <property type="entry name" value="PH-GRAM_MTMR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14586">
        <property type="entry name" value="PTP-MTMR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035888">
        <property type="entry name" value="MTMR3_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046352">
        <property type="entry name" value="MTMR3_PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF66">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="7">
        <location>
            <begin position="155"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="979"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1230"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="3">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="351"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="413"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1273" mass="141046" checksum="0381E6EEDC533A3A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV54</accession>
    <name>A0A5F8GV54_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carcinoembryonic antigen-related cell adhesion molecule 6-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV54"/>
    <dbReference type="Ensembl" id="ENSMODT00000045451.2">
        <property type="protein sequence ID" value="ENSMODP00000051508.1"/>
        <property type="gene ID" value="ENSMODG00000009507.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263479"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009507">
        <property type="expression patterns" value="Expressed in spermatid and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="336"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="426"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="510" mass="56972" checksum="73E1F9D392E2D1E6" modified="2019-12-11" version="1">MQGLLAAQTQKQNKNRQQSPSPSRSGSQSRSWSCSHSASPSPSPPRTGNRTAHCSNHHSSSYARPLTHSHHSHNANHHPSNTCPTRRKATGLAKRKAEIGRSPYKREKRADRRAPVLKRKIPVLWSRGSSLHRDRDRLWGSHTAFSLESSRDSSRETPTEETPCWTGEQRFLGRREAVTPDEQCRPMERPSEASQSRGSTWKGLLIITASILSCWSQPTSAQDITVEVEPPLGTQGLSVTFRIVGYSGTPVMYNWYYKTSAQQPSRKHIVTYSTYNRRQLQTNIRQRVYHNGSMFFPNLLVNDSGYYEVQIIKDRWTLDRPEAGAPLKVYVGLSKPNIVTSNNTAVENNDFTLTCNATGYLPSTTWYINQRVQHGTGRIRLSPDNKTLTLPKITRSENKGPYMCEMVNIVSHVNSDGFILDVAYGPDSMTILPAADRYNVGEHIQLTCSAQSCNPPAQLTWLQNGQPVSNSGTFSATAALNHAGNYTCVAYNSLTGIRHSQSMNIIIYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV59</accession>
    <name>A0A5F8GV59_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 200A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMEM200A</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM200 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV59"/>
    <dbReference type="FunCoup" id="A0A5F8GV59">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051430"/>
    <dbReference type="Ensembl" id="ENSMODT00000056918.1">
        <property type="protein sequence ID" value="ENSMODP00000051430.1"/>
        <property type="gene ID" value="ENSMODG00000023321.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100024522"/>
    <dbReference type="GeneTree" id="ENSGT00530000063698"/>
    <dbReference type="InParanoid" id="A0A5F8GV59"/>
    <dbReference type="OMA" id="FQPVSTM"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023321">
        <property type="expression patterns" value="Expressed in spermatid and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018787">
        <property type="entry name" value="DUF2371_TMEM200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815">
        <property type="entry name" value="AGAP005329-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 200A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10177">
        <property type="entry name" value="DUF2371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="524" mass="58655" checksum="109C78450AD4CFE2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV61</accession>
    <name>A0A5F8GV61_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoic acid synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LIAS</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV61"/>
    <dbReference type="Ensembl" id="ENSMODT00000052916.1">
        <property type="protein sequence ID" value="ENSMODP00000051259.1"/>
        <property type="gene ID" value="ENSMODG00000020554.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006234"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020554">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl synthase N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="226" mass="25625" checksum="890B0BC5642168AB" modified="2019-12-11" version="1">MSLRCGGVSRVLGSRVLGNYLCSQYKTFSSLPDKKKEFLQNGPDLQDFLSGDLSDKSTWAEYKGNLKRQKGERYVKKHGAPISGSAGEEESMLLLPPLSWQVRDPRANFDQSVQVLKHAKKVQPNVISKTSIMLGLGETDEQVYSTMKALREADVDCLTLGQYMQPTKRNLKVEEYVTPEKFKYWEKIGNELGFHYTASGPLVRSSYKAGEFFLKNLVEKRKTRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV62</accession>
    <name>A0A5F8GV62_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Heterogeneous nuclear ribonucleoprotein D-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HNRNPDL</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007495870.1">
        <property type="nucleotide sequence ID" value="XM_007495808.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV62"/>
    <dbReference type="Ensembl" id="ENSMODT00000056517.1">
        <property type="protein sequence ID" value="ENSMODP00000051518.1"/>
        <property type="gene ID" value="ENSMODG00000011916.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100010273"/>
    <dbReference type="CTD" id="9987"/>
    <dbReference type="GeneTree" id="ENSGT00940000154426"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011916">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12758">
        <property type="entry name" value="RRM1_hnRPDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12585">
        <property type="entry name" value="RRM2_hnRPDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000220">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein D-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000030">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein d0 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012956">
        <property type="entry name" value="CARG-binding_factor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034847">
        <property type="entry name" value="hnRPDL_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF2">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08143">
        <property type="entry name" value="CBFNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="145"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="230"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="310"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="360" mass="39637" checksum="BC266CE60F3900D8" modified="2019-12-11" version="1">MEVPPRLSQVPPPLFPSPPSALAPRNLSHWRPRAPRQLAPLLPSLSSGSARQGARRAPRHVTAPQPSRLAGGASIKGGRRRRPDLFRRHFKSGSIHRAAAATPSPRHLPPADSPAAMEDVNEYSNMEEFAEGSKINASKNQQDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLENRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGGTRGRGRGQQSTYGKASRGGGNHQNNYQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV63</accession>
    <name>A0A5F8GV63_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ras GTPase-activating protein-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GAP SH3 domain-binding protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">G3BP2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress. Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms homooligomers. Forms heterodimers with G3BP1. Interacts with NFKBIA (via N-terminus). Interacts (via NTF2 domain) with USP10; inhibiting stress granule formation. Interacts (via NTF2 domain) with CAPRIN1; promoting stress granule formation. Associates (via RG-rich region) with 40S ribosome subunits. Interacts with PABPC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_001365000.1">
        <property type="nucleotide sequence ID" value="XM_001364963.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056659313.1">
        <property type="nucleotide sequence ID" value="XM_056803335.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056659314.1">
        <property type="nucleotide sequence ID" value="XM_056803336.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056659315.1">
        <property type="nucleotide sequence ID" value="XM_056803337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV63"/>
    <dbReference type="Ensembl" id="ENSMODT00000073404.1">
        <property type="protein sequence ID" value="ENSMODP00000051387.1"/>
        <property type="gene ID" value="ENSMODG00000019205.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100015569"/>
    <dbReference type="CTD" id="9908"/>
    <dbReference type="GeneTree" id="ENSGT00390000011365"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019205">
        <property type="expression patterns" value="Expressed in brain and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12464">
        <property type="entry name" value="RRM_G3BP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000002">
        <property type="entry name" value="Ras GTPase-activating protein-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000327">
        <property type="entry name" value="ras GTPase-activating protein-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034376">
        <property type="entry name" value="G3BP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF10">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="NTF2" evidence="19">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="298"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="186"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="375"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="449" mass="50781" checksum="E4D2E99B504CC5FA" modified="2019-12-11" version="1">MVMEKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGGVDASGKPQEAVYGQNDIHHKVLSLKFSECHTKIRHVDAHATLSDGVVVQVMGLLSNSGQPDRKFMQTFVLAPEGSVPNKFYVHNDMFRYEDEVFCDSEPELDEESEEEVEEEQEERQPSPEPVQESANSAYYETHPVTNGIEEPLEESSHDPEPEPESETKTEELKPPVEEKNLEELEEKSASPPPAEPVSLPQEPPKPRIETKSEAQSQPPRVREQRPRERPGFPPRGPRPGRGDMEQNESDNRRIIRYPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELRINTKGVGGKLPNFGFVVFDDSEPVQRILVAKPIMFRGEVRLNVEEKKTRAARERETRGGGDDRRDLRRNDRGPGGPRGIVGGGMMRDRDGRGPPPRGGMAQKLGSGRGAGQMEGRFTGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV64</accession>
    <name>A0A5F8GV64_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenylate kinase 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AK9</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000055305.1">
        <property type="protein sequence ID" value="ENSMODP00000051264.1"/>
        <property type="gene ID" value="ENSMODG00000017956.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00740000115564"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017956">
        <property type="expression patterns" value="Expressed in spermatocyte and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="394"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="926"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="1344"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="666"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1140"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="982"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1845" mass="213045" checksum="CB35F02EF7E5FA51" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV65</accession>
    <name>A0A5F8GV65_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein 4.1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Band 4.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Erythrocyte membrane protein band 4.1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">EPB41</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV65"/>
    <dbReference type="Ensembl" id="ENSMODT00000067667.1">
        <property type="protein sequence ID" value="ENSMODP00000051523.1"/>
        <property type="gene ID" value="ENSMODG00000011038.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157833"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011038">
        <property type="expression patterns" value="Expressed in blood and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13184">
        <property type="entry name" value="FERM_C_4_1_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17105">
        <property type="entry name" value="FERM_F1_EPB41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000002">
        <property type="entry name" value="Erythrocyte protein band 4.1-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008379">
        <property type="entry name" value="Band_4.1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021187">
        <property type="entry name" value="EPB4.1_FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007477">
        <property type="entry name" value="SAB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF12">
        <property type="entry name" value="PROTEIN 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05902">
        <property type="entry name" value="4_1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04382">
        <property type="entry name" value="SAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002304">
        <property type="entry name" value="Membrane_skeletal_4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FERM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="308"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="666" mass="74755" checksum="958F1BD30873774D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV69</accession>
    <name>A0A5F8GV69_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NAD kinase</fullName>
            <ecNumber evidence="3">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Poly(P)/ATP NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NADK</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>NAD(+) + ATP = ADP + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="3"/>
    <dbReference type="RefSeq" id="XP_007481164.1">
        <property type="nucleotide sequence ID" value="XM_007481102.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV69"/>
    <dbReference type="Ensembl" id="ENSMODT00000078114.1">
        <property type="protein sequence ID" value="ENSMODP00000051397.1"/>
        <property type="gene ID" value="ENSMODG00000006845.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100012967"/>
    <dbReference type="CTD" id="65220"/>
    <dbReference type="GeneTree" id="ENSGT00390000013792"/>
    <dbReference type="OMA" id="QKAFKEW"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006845">
        <property type="expression patterns" value="Expressed in placenta and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000014">
        <property type="entry name" value="NAD kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000003">
        <property type="entry name" value="NAD kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="443" mass="49094" checksum="4AE681F6D251EC7B" modified="2019-12-11" version="1">MRTRACSQVDAAQCMAGRLRACLQFGELKPPSACQEKPDSFGDGSSLVGNKGELVQGVELWFGKKAMKLVRGVMNDVSWNRAAWKWHIQDPASQRLTWNKSPKSVLVIKKIRDASLLQPFKALCVYLMEENNMIVYVEKKVLEDPAIVNDEHFGAVKKKFCTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFNFENFQSQVTQVIEGNAAIVLRSRLKVKVVKELREKKGPVLQNGIDENGVLAPGLDKDSPKHMVNYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEICHGDSISITTSCYPLPSICFRDPVSDWFESLAECLHWNVRKKQNHFTGEEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV70</accession>
    <name>A0A5F8GV70_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Ryanodine receptor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RYR3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000055807.1">
        <property type="protein sequence ID" value="ENSMODP00000051096.1"/>
        <property type="gene ID" value="ENSMODG00000001626.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155507"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001626">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12877">
        <property type="entry name" value="SPRY1_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12878">
        <property type="entry name" value="SPRY2_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000019">
        <property type="entry name" value="Ryanodine receptor 1 (skeletal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000009">
        <property type="entry name" value="Ryanodine receptor 1 (skeletal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000040">
        <property type="entry name" value="Ryanodine receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000001">
        <property type="entry name" value="Ryanodine receptor 2 (Cardiac)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000006">
        <property type="entry name" value="Ryanodine receptor 2 (Cardiac)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000017">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000003">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035761">
        <property type="entry name" value="SPRY1_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035764">
        <property type="entry name" value="SPRY2_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035762">
        <property type="entry name" value="SPRY3_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF9">
        <property type="entry name" value="RYANODINE RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4129"/>
            <end position="4153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4357"/>
            <end position="4377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4425"/>
            <end position="4444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4556"/>
            <end position="4574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4617"/>
            <end position="4638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4697"/>
            <end position="4720"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="21">
        <location>
            <begin position="106"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="21">
        <location>
            <begin position="168"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="21">
        <location>
            <begin position="281"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="19">
        <location>
            <begin position="591"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="19">
        <location>
            <begin position="1018"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="19">
        <location>
            <begin position="1229"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="3872"/>
            <end position="3900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="3304"/>
            <end position="3323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="3537"/>
            <end position="3562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="4234"/>
            <end position="4327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="3552"/>
            <end position="3562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="4275"/>
            <end position="4305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="4816" mass="547979" checksum="EE1D198FCB457FD4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV72</accession>
    <name>A0A5F8GV72_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho guanine nucleotide exchange factor 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Collybistin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Rac/Cdc42 guanine nucleotide exchange factor 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ARHGEF9</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with GPHN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056664798.1">
        <property type="nucleotide sequence ID" value="XM_056808820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV72"/>
    <dbReference type="Ensembl" id="ENSMODT00000057805.1">
        <property type="protein sequence ID" value="ENSMODP00000051274.1"/>
        <property type="gene ID" value="ENSMODG00000020843.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100018406"/>
    <dbReference type="CTD" id="23229"/>
    <dbReference type="GeneTree" id="ENSGT00940000154103"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020843">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01224">
        <property type="entry name" value="PH_Collybistin_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11975">
        <property type="entry name" value="SH3_ARHGEF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000002">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000015">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000037">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035728">
        <property type="entry name" value="ARHGEF9_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544:SF4">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="649"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="16">
        <location>
            <begin position="744"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="959"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="447"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1095"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1157" mass="132355" checksum="38A2F75EC0B1E89A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV74</accession>
    <name>A0A5F8GV74_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Coiled-coil domain containing 88A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CCDC88A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCDC88 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000076103.1">
        <property type="protein sequence ID" value="ENSMODP00000051533.1"/>
        <property type="gene ID" value="ENSMODG00000001885.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155559"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001885">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22229">
        <property type="entry name" value="HkD_Girdin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000035">
        <property type="entry name" value="girdin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF30">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="966"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1369"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1488"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1666"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="202"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1088"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="980"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1374"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1401"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1497"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1522"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1695"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1718"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1738"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1751"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1768"/>
            <end position="1788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1801" mass="207520" checksum="44E4CD5410F05E94" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV75</accession>
    <name>A0A5F8GV75_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Kinesin family member 13B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KIF13B</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000079250.1">
        <property type="protein sequence ID" value="ENSMODP00000051440.1"/>
        <property type="gene ID" value="ENSMODG00000008823.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155500"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008823">
        <property type="expression patterns" value="Expressed in endometrium and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22730">
        <property type="entry name" value="FHA_KIF13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000002">
        <property type="entry name" value="Kinesin family member 13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000010">
        <property type="entry name" value="Kinesin family member 13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000009">
        <property type="entry name" value="Kinesin family member 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023862963" evidence="12">
        <location>
            <begin position="21"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="14">
        <location>
            <begin position="1373"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1305"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1465"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1305"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1471"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1487" mass="166372" checksum="EE24C79FD723A93C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV81</accession>
    <name>A0A5F8GV81_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory factor X associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RFXAP</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV81"/>
    <dbReference type="Ensembl" id="ENSMODT00000087796.1">
        <property type="protein sequence ID" value="ENSMODP00000051412.1"/>
        <property type="gene ID" value="ENSMODG00000009995.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006573"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009995">
        <property type="expression patterns" value="Expressed in forelimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.290.30">
        <property type="entry name" value="Regulatory factor X-associated C-terminal binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038308">
        <property type="entry name" value="RFXAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029316">
        <property type="entry name" value="RFXAP_RFXANK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15110">
        <property type="entry name" value="REGULATORY FACTOR X-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15110:SF2">
        <property type="entry name" value="REGULATORY FACTOR X-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15289">
        <property type="entry name" value="RFXA_RFXANK_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulatory factor X-associated protein RFXANK-binding" evidence="2">
        <location>
            <begin position="265"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="390" mass="41210" checksum="AAC1C37822DDE479" modified="2019-12-11" version="1">MKIPQIFIPRIKLQEHFRVTAPTVFSGLNKAEAIFLHMRNQSIEPHFSHLCLSRACGFLPPGFQTVSNTVTPSSSSLGLRRRKKKEYCAPAPSAPAAGVDVESGRSVARRVLDNQAQISSTEAQGAIEPAGGGGSTAPPAAAPPTSQLTLLVMQPCSAREEADAGAGAGAIRRPVASVATAPSPALGGCSSKNLMPGYEVAGNAEDEPAEIEVELLDASDPPGGGESTASPEELEDEETHSGGESGRASAGVAGGSYGGGSVSKTCTIEGCSETTSQVAKQRKPWMCKKHRNKMYKDKYKKKKSDQALSLAGSVKLEESTDGSASIGKQRTGSIGDRPARPTLLEQVLNQKRLALLRSPEVVQFLQRQQQLLNQQVLEQRQQQQFPGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV82</accession>
    <name>A0A5F8GV82_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium release activated channel regulator 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CRACR2A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV82"/>
    <dbReference type="Ensembl" id="ENSMODT00000071352.1">
        <property type="protein sequence ID" value="ENSMODP00000051445.1"/>
        <property type="gene ID" value="ENSMODG00000018326.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000033504"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018326">
        <property type="expression patterns" value="Expressed in heart and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051111">
        <property type="entry name" value="Ca-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311:SF3">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="201"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="311" mass="36481" checksum="5A79BBC86F150A60" modified="2019-12-11" version="1">MAAPEKRAIKGSRKARFGLKGSEVNTKAPEDAQWSETREQDPGKLDMLKKAQEFFQTCDTEGKGFIARKDMQRLHNELPLSLEDLEDVFDTLDADGNGFLTPEEFTCGFSHFFFSQKNSNSDEEGAQAQEEKVYQSRWEEVIDSRDEDEEDQFHMLMDKLGAQKVLQDESDIKQLWVQLKKDEPHLLSNFEEFLSRIFYQLQEAHKEKDELECALKKKIATYDEEVQNLYEEMEQQIKNEKEQFLLKDMKRFQCQSQELEQKLVSKEQELEQLVQKQKRVFHSAVFKIVPVLHSYTSLPLLYSLGHALYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV83</accession>
    <name>A0A5F8GV83_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450 4B1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CYP4B1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV83"/>
    <dbReference type="FunCoup" id="A0A5F8GV83">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051538"/>
    <dbReference type="Ensembl" id="ENSMODT00000084594.1">
        <property type="protein sequence ID" value="ENSMODP00000051538.1"/>
        <property type="gene ID" value="ENSMODG00000001709.4"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100023582"/>
    <dbReference type="GeneTree" id="ENSGT00940000161441"/>
    <dbReference type="InParanoid" id="A0A5F8GV83"/>
    <dbReference type="OMA" id="IQPAFRL"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001709">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20678">
        <property type="entry name" value="CYP4B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000005">
        <property type="entry name" value="cytochrome P450 4F22 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF149">
        <property type="entry name" value="CYTOCHROME P450 4B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="530" mass="61437" checksum="7B4519CDF27A169B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6T2</accession>
    <name>A0A5F8H6T2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dysferlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DYSF</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferlin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000063460.1">
        <property type="protein sequence ID" value="ENSMODP00000055492.1"/>
        <property type="gene ID" value="ENSMODG00000010868.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156187"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010868">
        <property type="expression patterns" value="Expressed in heart and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012560">
        <property type="entry name" value="Ferlin_A-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF44">
        <property type="entry name" value="DYSFERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08165">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01200">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1533"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="682"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="838"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1084"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1318"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1492"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1567" mass="178651" checksum="BF99FDDCA760AC2F" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6T4</accession>
    <name>A0A5F8H6T4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">von Willebrand factor A domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">VWA8</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits ATPase activity in vitro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000063636.1">
        <property type="protein sequence ID" value="ENSMODP00000055269.1"/>
        <property type="gene ID" value="ENSMODG00000014823.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006601"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014823">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000587">
        <property type="entry name" value="von Willebrand factor A domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000663">
        <property type="entry name" value="von Willebrand factor A domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000989">
        <property type="entry name" value="von Willebrand factor A domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="408"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="742"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1506"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1760"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1506"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1537"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1760"/>
            <end position="1769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1793" mass="202217" checksum="36AA84A4967EDBD1" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6U0</accession>
    <name>A0A5F8H6U0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myosin light chain 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MYL4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Myosin is a hexamer of 2 heavy chains and 4 light chains.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6U0"/>
    <dbReference type="FunCoup" id="A0A5F8H6U0">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055274"/>
    <dbReference type="Ensembl" id="ENSMODT00000075879.1">
        <property type="protein sequence ID" value="ENSMODP00000055274.1"/>
        <property type="gene ID" value="ENSMODG00000010887.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234570"/>
    <dbReference type="InParanoid" id="A0A5F8H6U0"/>
    <dbReference type="OMA" id="PMFQHIA"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010887">
        <property type="expression patterns" value="Expressed in lung and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060048">
        <property type="term" value="P:cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002026">
        <property type="term" value="P:regulation of the force of heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000019">
        <property type="entry name" value="Myosin light chain 1 skeletal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000056">
        <property type="entry name" value="Myosin light chain 1 skeletal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF1">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="2" id="KW-0518">Myosin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="222" mass="24581" checksum="291D19A7EF4A16FA" modified="2019-12-11" version="1">MPPKKPEPKKEAAKAALAPAPAPAPAPAPEAPKEPAFDPKSVKIDFSADQIEAHEWTPSSHQRFYYQDPNFLAIVSINMEFKEAFSLFDRTPAGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNAKMLDFETFLPILQHISRNKDQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMSESEVEQLMAGQEDANGCINYEAFVKHIMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6U3</accession>
    <name>A0A5F8H6U3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box and WD repeat domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FBXW2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6U3"/>
    <dbReference type="Ensembl" id="ENSMODT00000053659.1">
        <property type="protein sequence ID" value="ENSMODP00000055705.1"/>
        <property type="gene ID" value="ENSMODG00000019633.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151016"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019633">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd22131">
        <property type="entry name" value="F-box_FBXW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042627">
        <property type="entry name" value="FBXW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436">
        <property type="entry name" value="F-BOX/WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="249" mass="28340" checksum="8EF4BD75EFC89323" modified="2019-12-11" version="1">MERKDFETWLDNISVTFLSLTDLQKNESLDHLISLSGAIQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACRNLGWQIDDSVQDALHWKKVYLKAILRMKQLKDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCIYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAGGFTEVQGQVSLAQPWRSYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6U4</accession>
    <name>A0A5F8H6U4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Solute carrier family 12 member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC12A7</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6U4"/>
    <dbReference type="Ensembl" id="ENSMODT00000058413.1">
        <property type="protein sequence ID" value="ENSMODP00000055663.1"/>
        <property type="gene ID" value="ENSMODG00000000878.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157657"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000878">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000049">
        <property type="entry name" value="Solute carrier family 12 (potassium/chloride transporter), member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000076">
        <property type="entry name" value="KCL_cotranspt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF47">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01081">
        <property type="entry name" value="KCLTRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="17">
        <location>
            <begin position="93"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="17">
        <location>
            <begin position="388"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="17">
        <location>
            <begin position="446"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="18">
        <location>
            <begin position="721"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="984" mass="110513" checksum="936192AFD76870D4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6U6</accession>
    <name>A0A5F8H6U6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6U6"/>
    <dbReference type="Ensembl" id="ENSMODT00000087692.1">
        <property type="protein sequence ID" value="ENSMODP00000055279.1"/>
        <property type="gene ID" value="ENSMODG00000005565.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022614"/>
    <dbReference type="KEGG" id="mdo:100022614"/>
    <dbReference type="CTD" id="89944"/>
    <dbReference type="GeneTree" id="ENSGT00950000182942"/>
    <dbReference type="OMA" id="GSEIVHN"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005565">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000049">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000036">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="7">
        <location>
            <begin position="70"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="8">
        <location>
            <begin position="440"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="9">
        <location>
            <begin position="564"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="652" mass="74453" checksum="8C32A6732A067A7C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6U7</accession>
    <name>A0A5F8H6U7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras association domain family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RASSF4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6U7"/>
    <dbReference type="Ensembl" id="ENSMODT00000064896.1">
        <property type="protein sequence ID" value="ENSMODP00000054951.1"/>
        <property type="gene ID" value="ENSMODG00000010000.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160176"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010000">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17222">
        <property type="entry name" value="RA_RASSF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033614">
        <property type="entry name" value="RASSF1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033622">
        <property type="entry name" value="RASSF4_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF4">
        <property type="entry name" value="RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16517">
        <property type="entry name" value="Nore1-SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="174"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="3">
        <location>
            <begin position="270"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="316" mass="36238" checksum="FB6DD8E1597F2394" modified="2019-12-11" version="1">MDEELLPNSHVLISGNKSILKSELLSLLKTYNCYHEGRSFQLRHREEEGELIIEGLLNISWGLRRPIRLQMQDDNERIHLSTAPWKKDLSSINQKGLQQGARETIEESSPHAAVTSESSGTDSIDSINGEEETPQLMRTKSDASCMIQRRSKCRALGEAQKIKRHRFSINGHFYNHKTSVFTPAYGSVTNVRVNSTMTTVQVLTLLLNKFRVENGPSEFALYVVHESGERTKLKDCEYPLISRILHGPCEKIAKIFLMETDLGEEVPYDVAQYIKFEMPVLDSFVEKLKEEEEREIIKLTLKPHPRTSLVYHQEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6U8</accession>
    <name>A0A5F8H6U8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">OCA2 melanosomal transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">OCA2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6U8"/>
    <dbReference type="Ensembl" id="ENSMODT00000064002.1">
        <property type="protein sequence ID" value="ENSMODP00000055668.1"/>
        <property type="gene ID" value="ENSMODG00000000700.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234550"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000700">
        <property type="expression patterns" value="Expressed in digestive system and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01116">
        <property type="entry name" value="P_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="263"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="760" mass="84861" checksum="D92AAC70AA428DA7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6V0</accession>
    <name>A0A5F8H6V0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">procollagen-proline 3-dioxygenase</fullName>
            <ecNumber evidence="4">1.14.11.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">P3H2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-3-hydroxy-L-prolyl-[collagen] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:22872"/>
            <dbReference type="Rhea" id="RHEA-COMP:11676"/>
            <dbReference type="Rhea" id="RHEA-COMP:11678"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="EC" id="1.14.11.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the leprecan family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.7" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6V0"/>
    <dbReference type="Ensembl" id="ENSMODT00000066862.1">
        <property type="protein sequence ID" value="ENSMODP00000055512.1"/>
        <property type="gene ID" value="ENSMODG00000015073.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159593"/>
    <dbReference type="OMA" id="LICEHEC"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015073">
        <property type="expression patterns" value="Expressed in lung and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019797">
        <property type="term" value="F:procollagen-proline 3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032963">
        <property type="term" value="P:collagen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000003">
        <property type="entry name" value="Prolyl 3-hydroxylase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056585">
        <property type="entry name" value="Leprecan_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039575">
        <property type="entry name" value="P3H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14049">
        <property type="entry name" value="LEPRECAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14049:SF1">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23557">
        <property type="entry name" value="TPR_leprecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="10" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="16">
        <location>
            <begin position="530"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="684" mass="77943" checksum="0FBB0F167A1C4075" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6V2</accession>
    <name>A0A5F8H6V2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6V2"/>
    <dbReference type="Ensembl" id="ENSMODT00000056587.1">
        <property type="protein sequence ID" value="ENSMODP00000054956.1"/>
        <property type="gene ID" value="ENSMODG00000013291.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183007"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04104">
        <property type="entry name" value="p47_IIGP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000541">
        <property type="entry name" value="Immunity related GTPase M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF13">
        <property type="entry name" value="GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="5">
        <location>
            <begin position="57"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="IRG-type G" evidence="5">
        <location>
            <begin position="463"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="810" mass="91237" checksum="0124C3976B9CF5F5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6V5</accession>
    <name>A0A5F8H6V5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with hair keratins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the KRTAP type 4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6V5"/>
    <dbReference type="Ensembl" id="ENSMODT00000065547.1">
        <property type="protein sequence ID" value="ENSMODP00000055517.1"/>
        <property type="gene ID" value="ENSMODG00000036657.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163931"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000036657">
        <property type="expression patterns" value="Expressed in testis"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002494">
        <property type="entry name" value="KAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23262">
        <property type="entry name" value="KERATIN ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23262:SF248">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13885">
        <property type="entry name" value="Keratin_B2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0416">Keratin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="267" mass="28301" checksum="8C2C3D3EF8FD1A4B" modified="2025-10-08" version="2">MAAYPSTDTMVNSCCGSVCSDLSCGQDLCQETCCAPSCCRPNCCQSVCCQPNCCQTTCRPTCCRPTCCVSSCCQPCCRPSCCRPSCCRPRCCQSVCCQPTCCRPSCCQTTCCRTTCCRPSCCVCCRPSCCGSSCCHCCRPSCCGSNCCQPCCRPTCCTPSCCQPCCHPTCCITSCCRPSCCQPCCRPTCCTPSCCQPCCRPTCCITSCCRPSCCQPCCRPTCCISSCCQPCCRPTCCTSSCCQPCCCQTTCCRTTCCRPACCGSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6V6</accession>
    <name>A0A5F8H6V6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Ras-related protein Rab-28</fullName>
            <ecNumber evidence="6">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">RAB28</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="25">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB28 is required for shedding and phagocytosis of cone cell outer segments (OS) discs in the retina. Also participates in nuclear factor kappa-B p65/RELA nuclear transport in endothelial cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6V6"/>
    <dbReference type="Ensembl" id="ENSMODT00000068813.1">
        <property type="protein sequence ID" value="ENSMODP00000055289.1"/>
        <property type="gene ID" value="ENSMODG00000001223.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164241"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001223">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000513">
        <property type="entry name" value="ras-related protein Rab-28 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0636">Prenylation</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00039505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00093324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="203" mass="23086" checksum="D669B591C0AAA726" modified="2019-12-11" version="1">MLASEIYQTSLATRFAQEAFGKQYKQTVGLDFFLKRITLPGNLNATLQVWDIGGQTIGGKMLDKYIYGAQGILLVYDITNYQSFENLEDWYNMVKKVNEESETQPLVALVGNKIDLEHMRTVKPDKHLRFCQENGLSSHFVSAKTGDSVFLCFQRVAAEILGIKLNKAEIEQSQRIVRAEIVKYPEEDNQHLNSTQSKICSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6V7</accession>
    <name>A0A5F8H6V7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Low affinity sodium-glucose cotransporter-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6V7"/>
    <dbReference type="Ensembl" id="ENSMODT00000060633.1">
        <property type="protein sequence ID" value="ENSMODP00000055522.1"/>
        <property type="gene ID" value="ENSMODG00000010004.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160846"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010004">
        <property type="expression patterns" value="Expressed in spermatid and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000005">
        <property type="entry name" value="sodium/glucose cotransporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF112">
        <property type="entry name" value="GLUCOSE SENSOR PROTEIN SLC5A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="620" mass="68052" checksum="8C6501642054E241" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6V9</accession>
    <name>A0A5F8H6V9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-patch domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GPATCH2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6V9"/>
    <dbReference type="FunCoup" id="A0A5F8H6V9">
        <property type="interactions" value="2929"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055720"/>
    <dbReference type="Ensembl" id="ENSMODT00000088066.1">
        <property type="protein sequence ID" value="ENSMODP00000055720.1"/>
        <property type="gene ID" value="ENSMODG00000004195.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00410000025698"/>
    <dbReference type="InParanoid" id="A0A5F8H6V9"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004195">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="466"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="621" mass="69492" checksum="58E3623233E82D02" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6W1</accession>
    <name>A0A5F8H6W1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multidrug resistance-associated protein 1</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
            <ecNumber evidence="14">7.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-binding cassette sub-family C member 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Glutathione-S-conjugate-translocating ATPase ABCC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Leukotriene C(4) transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">ABCC1</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82961"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:60129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:74887"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143093"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione(in) + ATP + H2O = S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81611"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:156326"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:81612"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33147"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64677"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:33148"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>prostaglandin A2-S-(R)-glutathione(in) + ATP + H2O = prostaglandin A2-S-(R)-glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81695"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:133768"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:81696"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>prostaglandin A2-S-(S)-glutathione(in) + ATP + H2O = prostaglandin A2-S-(S)-glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:133769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:81700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38951"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60119"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:38952"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>vincristine(in) + ATP + H2O = vincristine(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60160"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143658"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:60161"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EC" id="7.6.2.3" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6W1"/>
    <dbReference type="Ensembl" id="ENSMODT00000075512.1">
        <property type="protein sequence ID" value="ENSMODP00000055294.1"/>
        <property type="gene ID" value="ENSMODG00000004194.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160271"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004194">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000293">
        <property type="entry name" value="ATP binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000007">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF241">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 30" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="728"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="826"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="32">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="31">
        <location>
            <begin position="317"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="32">
        <location>
            <begin position="707"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="31">
        <location>
            <begin position="920"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1158" mass="129071" checksum="907EF37C487289B9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6W2</accession>
    <name>A0A5F8H6W2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ITGB8</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Required during vasculogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterodimer of an alpha and a beta subunit. Beta-8 (ITGB8) associates with alpha-V (ITGAV) to form ITGAV:ITGB8. ITGAV:ITGB8 interacts with TGFB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Cell membrane</location>
            <topology evidence="1 20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6W2"/>
    <dbReference type="Ensembl" id="ENSMODT00000068332.1">
        <property type="protein sequence ID" value="ENSMODP00000055527.1"/>
        <property type="gene ID" value="ENSMODG00000001388.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286919"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001388">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034686">
        <property type="term" value="C:integrin alphav-beta8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000076">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000370">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1510:FF:000010">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF9">
        <property type="entry name" value="INTEGRIN BETA-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002512">
        <property type="entry name" value="Integrin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 20" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 20" id="KW-0401">Integrin</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023931331" description="Integrin beta" evidence="22">
        <location>
            <begin position="23"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="469"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="490"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="525"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="527"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="566"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="606"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="608"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="626"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00063793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR002512-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="744" mass="81275" checksum="8A577E84E3AA526E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6W3</accession>
    <name>A0A5F8H6W3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kelch-like protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">KLHL22</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1. Interacts with PLK1. Interacts with DEPDC5 (via DEP domain); the interaction depends on amino acid availability. Interacts with YWHAE; required for the nuclear localization of KLHL22 upon amino acid starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6W3"/>
    <dbReference type="Ensembl" id="ENSMODT00000053371.1">
        <property type="protein sequence ID" value="ENSMODP00000055725.1"/>
        <property type="gene ID" value="ENSMODG00000014290.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159598"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014290">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18461">
        <property type="entry name" value="BACK_KLHL22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18251">
        <property type="entry name" value="BTB_POZ_KLHL22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000018">
        <property type="entry name" value="Kelch-like family member 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000040">
        <property type="entry name" value="Kelch-like family member 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000083">
        <property type="entry name" value="Kelch-like family member 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030575">
        <property type="entry name" value="KLHL22_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF5">
        <property type="entry name" value="KELCH-LIKE PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="21">
        <location>
            <begin position="82"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="633"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="670" mass="76207" checksum="1F945E839C330401" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H753</accession>
    <name>A0A5F8H753_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AT-rich interactive domain-containing protein 3</fullName>
            <shortName evidence="8">ARID domain-containing protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ARID3A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Heterodimer with ARID3B. Interacts with E2F1. Interacts with GTF2I and BTK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H753"/>
    <dbReference type="Ensembl" id="ENSMODT00000071717.1">
        <property type="protein sequence ID" value="ENSMODP00000055815.1"/>
        <property type="gene ID" value="ENSMODG00000005667.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160899"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005667">
        <property type="expression patterns" value="Expressed in forelimb bud and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16878">
        <property type="entry name" value="ARID_ARID3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000006">
        <property type="entry name" value="AT-rich interactive domain-containing protein 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045147">
        <property type="entry name" value="ARI3A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023334">
        <property type="entry name" value="REKLES_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15348:SF1">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15348">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN ARID DOMAIN- CONTAINING PROTEIN DEAD RINGER PROTEIN B-CELL REGULATOR OF IGH TRANSCRIPTION BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51486">
        <property type="entry name" value="REKLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="10">
        <location>
            <begin position="252"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="REKLES" evidence="11">
        <location>
            <begin position="458"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="605" mass="66113" checksum="FA886DA11F775AD6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H760</accession>
    <name>A0A5F8H760_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bardet-Biedl syndrome 5 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">KLHL41</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell projection</location>
            <location evidence="1 10">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the BBS5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H760"/>
    <dbReference type="Ensembl" id="ENSMODT00000084721.1">
        <property type="protein sequence ID" value="ENSMODP00000055061.1"/>
        <property type="gene ID" value="ENSMODG00000008022.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158859"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008022">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006606">
        <property type="entry name" value="BBL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030804">
        <property type="entry name" value="BBS5/fem-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014003">
        <property type="entry name" value="BBS5_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351">
        <property type="entry name" value="BARDET-BIEDL SYNDROME PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07289">
        <property type="entry name" value="BBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010072">
        <property type="entry name" value="DUF1448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00683">
        <property type="entry name" value="DM16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="11">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="11">
        <location>
            <begin position="158"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="320" mass="36595" checksum="7EFE2A4D58FBAF43" modified="2019-12-11" version="1">MSVLDALWEDRDVRFDVSSQQMKTRPGEVLIDCLDSIEDTKGNNGDRGRLLVTNLRIIWHSLALPRVNLSVGYNCIINITTRTANSKLRGQTEALYILTKCNNTRFEFIFTNVVPGNPRLFTSVISVHRAYETSKMYRDFKLRSALIQNKQLKLLPQEQVYDKINGVWNLSSDQGNLGTFFITNVRIVWHANMNDNFNVSIPYLQISGGYVLGFKIDPVEKLQESVKEINSLHRVYSASPIFGVDYEMEEKPQPLEDLTVEQIQDDVEIDSDEHTDAFVAYFADGNKQQDREPVFSEELGLAIEKLKDGFTLQGLWEVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H761</accession>
    <name>A0A5F8H761_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="14">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PLCB4</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58433"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="16">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H761"/>
    <dbReference type="Ensembl" id="ENSMODT00000057602.1">
        <property type="protein sequence ID" value="ENSMODP00000055820.1"/>
        <property type="gene ID" value="ENSMODG00000004697.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156426"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004697">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120548">
        <property type="term" value="F:phosphatidylinositol phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16211">
        <property type="entry name" value="EFh_PI-PLCbeta4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1230.10:FF:000002">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.240:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14 17" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8 14 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="21">
        <location>
            <begin position="570"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="20">
        <location>
            <begin position="669"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="843"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1048"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1119"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="886"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1056"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1143"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1155" mass="131721" checksum="EC3A64B6CE65619C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H763</accession>
    <name>A0A5F8H763_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dpy-19 like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DPY19L4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H763"/>
    <dbReference type="Ensembl" id="ENSMODT00000077788.1">
        <property type="protein sequence ID" value="ENSMODP00000055632.1"/>
        <property type="gene ID" value="ENSMODG00000007155.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063023"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007155">
        <property type="expression patterns" value="Expressed in endometrium and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF2">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="673"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="719" mass="83199" checksum="3CF4F3B469883BD9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H764</accession>
    <name>A0A5F8H764_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 106</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H764"/>
    <dbReference type="FunCoup" id="A0A5F8H764">
        <property type="interactions" value="827"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055389"/>
    <dbReference type="Ensembl" id="ENSMODT00000059286.1">
        <property type="protein sequence ID" value="ENSMODP00000055389.1"/>
        <property type="gene ID" value="ENSMODG00000014049.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013183"/>
    <dbReference type="InParanoid" id="A0A5F8H764"/>
    <dbReference type="OMA" id="CRSKQPP"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014049">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031591">
        <property type="entry name" value="CCDC106"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16477">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16477:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15794">
        <property type="entry name" value="CCDC106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="334" mass="36846" checksum="10E0DA9794CD529D" modified="2019-12-11" version="1">MSERNGRRRTSEHNPPFPPGVPQSPTAPGPGAAPPSACHSPPLPRSPVGAGGALSARVPPSLPVKKDDEGFEISIPFNETPSLESPHIFYSLSPPQGNFEEPPEPASPTLALMNSVKTQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISSARMDAEDHCRGKPGPRRAEGADGRGGGEASDPESAASSLSGGSEEGGSAERKRQKQKGGASRRRFGKPKARERQRVKDADGVLCRYKKILGTFQKLKSMSRAFEHHRVDRNTVALTTPIAELLIVAPEKLAEVGEFDPSKERLLEYSRRCFLALDDETLKKVQALKKSKLLLPITYRFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H767</accession>
    <name>A0A5F8H767_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Jupiter microtubule associated homolog 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">JPT2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JUPITER family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H767"/>
    <dbReference type="Ensembl" id="ENSMODT00000069416.1">
        <property type="protein sequence ID" value="ENSMODP00000055793.1"/>
        <property type="gene ID" value="ENSMODG00000016153.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007652"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016153">
        <property type="expression patterns" value="Expressed in spermatid and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033335">
        <property type="entry name" value="JUPITER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34930">
        <property type="entry name" value="GEO05313P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34930:SF5">
        <property type="entry name" value="JUPITER MICROTUBULE ASSOCIATED HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17054">
        <property type="entry name" value="JUPITER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="70" mass="7481" checksum="A3AF6C729568B0CD" modified="2019-12-11" version="1">MFQGLENEGGKSNSRGMKPPGGDSSNLFGTPEEVNPSNRPNRMASNIFGASKEPQNTPKRSNPPGSYCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H768</accession>
    <name>A0A5F8H768_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho GTPase-activating protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rho-type GTPase-activating protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ARHGAP12</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H768"/>
    <dbReference type="Ensembl" id="ENSMODT00000056700.1">
        <property type="protein sequence ID" value="ENSMODP00000055637.1"/>
        <property type="gene ID" value="ENSMODG00000007821.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182860"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007821">
        <property type="expression patterns" value="Expressed in uterine wall and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13233">
        <property type="entry name" value="PH_ARHGAP9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04403">
        <property type="entry name" value="RhoGAP_ARHGAP27_15_12_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12070">
        <property type="entry name" value="SH3_ARHGAP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000003">
        <property type="entry name" value="Putative rho GTPase-activating protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000024">
        <property type="entry name" value="Rho GTPase activating protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000100">
        <property type="entry name" value="Rho GTPase activating protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000056">
        <property type="entry name" value="rho GTPase-activating protein 12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035491">
        <property type="entry name" value="ARHGAP12_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF107">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16618">
        <property type="entry name" value="SH3-WW_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="398"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="13">
        <location>
            <begin position="580"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="770" mass="87193" checksum="342DD70EF1DA7F68" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H769</accession>
    <name>A0A5F8H769_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Synaptogyrin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SYNGR3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptogyrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H769"/>
    <dbReference type="STRING" id="13616.ENSMODP00000055830"/>
    <dbReference type="Ensembl" id="ENSMODT00000056446.1">
        <property type="protein sequence ID" value="ENSMODP00000055830.1"/>
        <property type="gene ID" value="ENSMODG00000016066.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182935"/>
    <dbReference type="InParanoid" id="A0A5F8H769"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016066">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016579">
        <property type="entry name" value="Synaptogyrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838:SF8">
        <property type="entry name" value="SYNAPTOGYRIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="191"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="400" mass="43903" checksum="05265B9EF5966606" modified="2019-12-11" version="1">MKAVRSGSVRGSSPRLRSLYKRPSKERSEAQSSPRANGRHKSRTDQRSTLQRSTLLFYWRKQKSETSSKCSLAEDGKPETDLENTETGAGPRPEAGAVSKAGLGLKLGLGLAWKLREAAYPSMPWASKMAAPGEGRRFSPASFFSFLPGGARPQETKEQVASETAGADGDATVRKRPCRACVDFKTWMKTQKALKTSESDTQVAVFSIVVFGSIVNEGYVNSDSTPELHCIYNKNEGACNYGITIGIIAFFACIFFLVLDLNFQEISSVKDRRRAVLLDLGFSGLWSFLWFVCFCFLANQWQQTKKSEEVNQGADAARAGIAFSFFSILTWVALMVKALQRYRLGTDMSLFATEQLSAAPGTSYPGYPAGSGVEGTETYQSPPFTETLDTSPKGYQVPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H770</accession>
    <name>A0A5F8H770_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000053453.1">
        <property type="protein sequence ID" value="ENSMODP00000055394.1"/>
        <property type="gene ID" value="ENSMODG00000010731.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154063"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010731">
        <property type="expression patterns" value="Expressed in liver and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006957">
        <property type="term" value="P:complement activation, alternative pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00017">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.130.20:FF:000001">
        <property type="entry name" value="Complement C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.120:FF:000013">
        <property type="entry name" value="Complement C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000155">
        <property type="entry name" value="complement C3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.91.20">
        <property type="entry name" value="Anaphylotoxins (complement system)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000020">
        <property type="entry name" value="Anaphylatoxin/fibulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018081">
        <property type="entry name" value="Anaphylatoxin_comp_syst"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041425">
        <property type="entry name" value="C3/4/5_MG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF81">
        <property type="entry name" value="COMPLEMENT C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01821">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17790">
        <property type="entry name" value="MG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00104">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47686">
        <property type="entry name" value="Anaphylotoxins (complement system)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01178">
        <property type="entry name" value="ANAPHYLATOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0179">Complement alternate pathway</keyword>
    <keyword evidence="4" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Anaphylatoxin-like" evidence="9">
        <location>
            <begin position="619"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="10">
        <location>
            <begin position="1344"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1497" mass="169580" checksum="FCCEB5FE191A7BB2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H771</accession>
    <name>A0A5F8H771_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PITRM1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. It is also able to degrade amyloid-beta protein 42.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H771"/>
    <dbReference type="FunCoup" id="A0A5F8H771">
        <property type="interactions" value="2053"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000078108.1">
        <property type="protein sequence ID" value="ENSMODP00000055071.1"/>
        <property type="gene ID" value="ENSMODG00000006591.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018381"/>
    <dbReference type="InParanoid" id="A0A5F8H771"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006591">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000020">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="16">
        <location>
            <begin position="498"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1027" mass="117097" checksum="06AAEEABD243781B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H775</accession>
    <name>A0A5F8H775_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exocyst complex component 3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EXOC3L1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">As part of the exocyst, may play a role in regulated exocytosis of insulin granules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H775"/>
    <dbReference type="FunCoup" id="A0A5F8H775">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055399"/>
    <dbReference type="Ensembl" id="ENSMODT00000075633.1">
        <property type="protein sequence ID" value="ENSMODP00000055399.1"/>
        <property type="gene ID" value="ENSMODG00000006186.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234613"/>
    <dbReference type="InParanoid" id="A0A5F8H775"/>
    <dbReference type="OMA" id="REQEPNT"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006186">
        <property type="expression patterns" value="Expressed in testis and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030072">
        <property type="term" value="P:peptide hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000001">
        <property type="entry name" value="Exocyst complex component 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000009">
        <property type="entry name" value="Exocyst complex component 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="756" mass="84047" checksum="3A731E50281CBB48" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H776</accession>
    <name>A0A5F8H776_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 98 member C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM98C</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H776"/>
    <dbReference type="Ensembl" id="ENSMODT00000077730.1">
        <property type="protein sequence ID" value="ENSMODP00000055076.1"/>
        <property type="gene ID" value="ENSMODG00000049877.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000037341"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000049877">
        <property type="expression patterns" value="Expressed in lung and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF10">
        <property type="entry name" value="PROTEIN FAM98C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="137" mass="15436" checksum="EE80001358841F1D" modified="2019-12-11" version="1">MWALSALSSYLRDQYCYRRRLMLTRLDLTASAFHWTDRAQSQGAAMTNVLKPLRQGLAPESAISLAHVLASRADLSRLVPATGRAARLVTCCPINKVLMGPVPDRGGRPNELEAPMPSWQSRREAGHQRWGRKKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H777</accession>
    <name>A0A5F8H777_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hepatoma-derived growth factor-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HDGFL2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HDGF family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000067133.1">
        <property type="protein sequence ID" value="ENSMODP00000055840.1"/>
        <property type="gene ID" value="ENSMODG00000000988.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153942"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000988">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20149">
        <property type="entry name" value="PWWP_HDGFL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000017">
        <property type="entry name" value="hepatoma-derived growth factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036218">
        <property type="entry name" value="HIVI-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021567">
        <property type="entry name" value="LEDGF_IBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF18">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11467">
        <property type="entry name" value="LEDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140576">
        <property type="entry name" value="HIV integrase-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="13">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="185"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="642"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="403"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="512"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="685"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="760" mass="84373" checksum="7666AB5A22D04DCD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H782</accession>
    <name>A0A5F8H782_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin binding LIM protein family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ABLIM2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H782"/>
    <dbReference type="Ensembl" id="ENSMODT00000086419.1">
        <property type="protein sequence ID" value="ENSMODP00000055652.1"/>
        <property type="gene ID" value="ENSMODG00000003062.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182850"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003062">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09327">
        <property type="entry name" value="LIM1_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09328">
        <property type="entry name" value="LIM2_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09329">
        <property type="entry name" value="LIM3_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09330">
        <property type="entry name" value="LIM4_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000003">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000007">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000171">
        <property type="entry name" value="Actin-binding LIM protein family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000053">
        <property type="entry name" value="Actin-binding LIM protein family, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF6">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="82"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="151"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="598" mass="66514" checksum="7E52D1975A1BB7AE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H783</accession>
    <name>A0A5F8H783_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibroblast growth factor</fullName>
            <shortName evidence="2">FGF</shortName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H783"/>
    <dbReference type="Ensembl" id="ENSMODT00000068181.1">
        <property type="protein sequence ID" value="ENSMODP00000055845.1"/>
        <property type="gene ID" value="ENSMODG00000014019.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163347"/>
    <dbReference type="OMA" id="NTEPEXL"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014019">
        <property type="expression patterns" value="Expressed in spinal cord and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23329">
        <property type="entry name" value="beta-trefoil_FGF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000001">
        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="213" mass="23881" checksum="279443A635457519" modified="2019-12-11" version="1">MGISCHHLIVKRRETEAKGKRRGLTQKPTEPQLKGIVTKLYSRQGYHLQLQADGTVDGTKEEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYPSEHFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGGKSMSPNEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F6SFD7</accession>
    <name>F6SFD7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NCK associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NCKAP5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000037809.3">
        <property type="protein sequence ID" value="ENSMODP00000036220.3"/>
        <property type="gene ID" value="ENSMODG00000024919.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063607"/>
    <dbReference type="HOGENOM" id="CLU_002885_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000024919">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032769">
        <property type="entry name" value="NCKAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026163">
        <property type="entry name" value="Nckap5l"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21740">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21740:SF0">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15246">
        <property type="entry name" value="NCKAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nck-associated protein 5 C-terminal" evidence="3">
        <location>
            <begin position="1425"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1493"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1584"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1684"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1866"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1815"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1304"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1338"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1503"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1586"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1620"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1866"/>
            <end position="1878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000036220.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1912" mass="210456" checksum="2F1E2CA9CC317B18" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>F6W0M8</accession>
    <name>F6W0M8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="30">Myosin IXA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">MYO9A</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000002408.4">
        <property type="protein sequence ID" value="ENSMODP00000002358.3"/>
        <property type="gene ID" value="ENSMODG00000001934.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154905"/>
    <dbReference type="HOGENOM" id="CLU_000192_2_2_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001934">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034330">
        <property type="term" value="P:cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20883">
        <property type="entry name" value="C1_Myosin-IXa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01385">
        <property type="entry name" value="MYSc_Myo9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17216">
        <property type="entry name" value="RA_Myosin-IXa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000003">
        <property type="entry name" value="Putative unconventional myosin-IXa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000020">
        <property type="entry name" value="Putative unconventional myosin-IXa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000008">
        <property type="entry name" value="Putative unconventional myosin-IXa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000003">
        <property type="entry name" value="unconventional myosin-IXa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000005">
        <property type="entry name" value="unconventional myosin-IXa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000121">
        <property type="entry name" value="unconventional myosin-IXa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000013">
        <property type="entry name" value="unconventional myosin-IXa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000013">
        <property type="entry name" value="unconventional myosin-IXa isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000009">
        <property type="entry name" value="unconventional myosin-IXb isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046987">
        <property type="entry name" value="Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036023">
        <property type="entry name" value="MYSc_Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028558">
        <property type="entry name" value="RA_Myosin-IXa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184:SF3">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="23" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="16 24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 23" id="KW-0505">Motor protein</keyword>
    <keyword evidence="17 23" id="KW-0518">Myosin</keyword>
    <keyword evidence="10 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0770">Synapse</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ras-associating" evidence="27">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="29">
        <location>
            <begin position="147"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="26">
        <location>
            <begin position="2061"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="28">
        <location>
            <begin position="2125"/>
            <end position="2253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="23">
        <location>
            <begin position="899"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1310"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1679"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1746"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1803"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1859"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="1490"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1314"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="1705"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1823"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1881"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="240"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000002358.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2253" mass="260269" checksum="F6BC1E651997D9F1" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>F6W0N5</accession>
    <name>F6W0N5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proprotein convertase subtilisin/kexin type 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Proprotein convertase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Proprotein convertase 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Subtilisin/kexin-like protease PC5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">PCSK5</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Endomembrane system</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 23 24">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="MEROPS" id="S08.076"/>
    <dbReference type="Ensembl" id="ENSMODT00000002407.4">
        <property type="protein sequence ID" value="ENSMODP00000002357.4"/>
        <property type="gene ID" value="ENSMODG00000001932.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155770"/>
    <dbReference type="HOGENOM" id="CLU_003159_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001932">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007565">
        <property type="term" value="P:female pregnancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000011">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000018">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000035">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000037">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000049">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000053">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000057">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.850:FF:000001">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000002">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000022">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF7">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 23 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0635">Pregnancy</keyword>
    <keyword evidence="4 23 24" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 23 24" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 25" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023933010" description="Proprotein convertase subtilisin/kexin type 5" evidence="25">
        <location>
            <begin position="32"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="26">
        <location>
            <begin position="460"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="22 23">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="22 23">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="22 23">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000002357.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1726" mass="191845" checksum="73AA559CC02FDAED" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F7CRN7</accession>
    <name>F7CRN7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DYNC1LI2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 14">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7CRN7"/>
    <dbReference type="Ensembl" id="ENSMODT00000029809.2">
        <property type="protein sequence ID" value="ENSMODP00000028228.2"/>
        <property type="gene ID" value="ENSMODG00000006873.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008295"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006873">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7CRN7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF1">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 14" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="293"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="360"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000028228.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="416" mass="45344" checksum="B67D5147FB3B883C" modified="2019-12-11" version="2">MAPVGVEKKLLLGPEGTGAPGAGDLPNEEDEGQNLWSSILSEVSTRSRSKLPSGKNILVFGEDGSGKTTLLAKLQGAEHSKKGRGLEYLYLNIHDEDRDVVKDFQEYVEPEEGYQGSPQRRGPLASAQDGENVILPLGDNMLTHNLGIPVLVVCTKCDAVSVLEKEHDYREEHFDFIQSHVRKFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPDDPYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSFLAKQPATPTRASESPARGPTGSPRTQGRAGPTNVPSASPITSVKKADPNIKNNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQGTAKKSGQKTVLTNVQEELDRMTRKPDSMVTANSSTENEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F7DUQ0</accession>
    <name>F7DUQ0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial genome maintenance exonuclease 1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">MGME1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endonuclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MGME1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="F7DUQ0"/>
    <dbReference type="Ensembl" id="ENSMODT00000030130.2">
        <property type="protein sequence ID" value="ENSMODP00000028546.1"/>
        <property type="gene ID" value="ENSMODG00000005495.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003349"/>
    <dbReference type="HOGENOM" id="CLU_068902_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005495">
        <property type="expression patterns" value="Expressed in blood and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7DUQ0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008297">
        <property type="term" value="F:single-stranded DNA exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000005">
        <property type="entry name" value="Mitochondrial genome maintenance exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03030">
        <property type="entry name" value="MGME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340:SF3">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK endonuclease-like" evidence="9">
        <location>
            <begin position="53"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000028546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="255" mass="29172" checksum="573EA6DE000889FB" modified="2011-07-27" version="1">LKMQSLSSICKKLGRSSRLFVELTPSISFSTSCYFCSQKKKNNSYQEVDQNRYSNLTHSIVSTRVCSQTPESLLQEDELLYGPVNIFLQGKHFHEVLEAMLSSPEQLKELNEKTINSGYVTSVQHVLKDISGVRALESAVHHETLKYLGLMDCVAEYRGKLCVIDWKTSEKPKPFIRNTFDNPLQVVAYVGAINHDANYNFEVQCGLIVVAYKNGSPAHTHFMDSDLCSQYWSKWLLRLEKYTEKEKNQTTENPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F7DV39</accession>
    <name>F7DV39_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F7DV39"/>
    <dbReference type="Ensembl" id="ENSMODT00000004690.4">
        <property type="protein sequence ID" value="ENSMODP00000004590.4"/>
        <property type="gene ID" value="ENSMODG00000029594.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SA5D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075201"/>
    <dbReference type="HOGENOM" id="CLU_083214_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000029594">
        <property type="expression patterns" value="Expressed in blood and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7DV39">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16095">
        <property type="entry name" value="IgV_H_TCR_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001810">
        <property type="entry name" value="T cell receptor delta constant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:003230">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000004590.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="290" mass="31888" checksum="D7894E5EE12C25BD" modified="2019-12-11" version="3">ISNLIPTLLTCRDETYLKESGGGLYPGNEILNLTCQTSGFQFNTSVLGWYLWDPGCAPQWLSSLDHISTETKEERIISSREDSSSQIFLQIKGLGIGDSGNYHCTKRVGDGDNTDKLVFGPGTDVIIEPGPRAPLTPSVFLLRSQDAVACLVSDFYPKDLNVSLASSRASIPGQVLTVAPTARGTYSAIQIGRVDENDAVICSVQHLGKEIHMSHKSDSLKLEPSYPDQKFKDELKMNGKRAEIMELSLNMIGTESEERNKLLLSVLSLRLLFMKTVAINVLFTMIALIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F7E6Q0</accession>
    <name>F7E6Q0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Leucine rich repeat transmembrane neuronal 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LRRTM4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Postsynaptic cell membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the LRRTM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7E6Q0"/>
    <dbReference type="Ensembl" id="ENSMODT00000021174.3">
        <property type="protein sequence ID" value="ENSMODP00000020807.3"/>
        <property type="gene ID" value="ENSMODG00000016671.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154909"/>
    <dbReference type="HOGENOM" id="CLU_032965_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016671">
        <property type="expression patterns" value="Expressed in spinal cord and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000005">
        <property type="entry name" value="leucine-rich repeat transmembrane neuronal protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF19">
        <property type="entry name" value="LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023927886" evidence="13">
        <location>
            <begin position="36"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000020807.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="545" mass="61770" checksum="FE942C74B44E6841" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F7F9U9</accession>
    <name>F7F9U9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acrosin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acrosin-binding protein, 60 kDa form</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Proacrosin-binding protein sp32</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Acrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7F9U9"/>
    <dbReference type="Ensembl" id="ENSMODT00000037395.3">
        <property type="protein sequence ID" value="ENSMODP00000035810.2"/>
        <property type="gene ID" value="ENSMODG00000018101.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R6TS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000826"/>
    <dbReference type="HOGENOM" id="CLU_534141_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018101">
        <property type="expression patterns" value="Expressed in spermatocyte and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009865">
        <property type="entry name" value="Proacrosin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21362">
        <property type="entry name" value="ACROSIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21362:SF1">
        <property type="entry name" value="ACROSIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07222">
        <property type="entry name" value="PBP_sp32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023806261" description="Acrosin-binding protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000035810.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="319" mass="34943" checksum="E97CB2A22C69B63B" modified="2019-12-11" version="2">MRSQASGLPLPLLAAILLAPTPAPFPTPDLDVPGTPLSPAEYERFFSALTPTWKAETACRLRATQGCQNHKLVQLDQYENHGTLPKGSVCTDLPYASWFESFCQFTQYRCSNRLFYAKRVLCSPSIPALSIHARSDSTTVPFSLSSVPTGNKVSLGEEVKEMKSEITALPSSGPNNEGLTPQTSQPWSDQLYPNIEELLKFPHSLEGQNSETYTESPYPSPLPSPVVIESIRALIQSSQALGGQNKTTLADEEPSPRSTDFHHPRSFSSSLLSLPGEEAMLVLCYAILSGSCPASLVAKAWQYIEQQMYGFKHEVFNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>F7F9W2</accession>
    <name>F7F9W2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Tensin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TNS3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000012092.4">
        <property type="protein sequence ID" value="ENSMODP00000011869.4"/>
        <property type="gene ID" value="ENSMODG00000009498.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1930">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156328"/>
    <dbReference type="HOGENOM" id="CLU_002189_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009498">
        <property type="expression patterns" value="Expressed in endometrium and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01213">
        <property type="entry name" value="PTB_tensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14561">
        <property type="entry name" value="PTP_tensin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09927">
        <property type="entry name" value="SH2_Tensin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000039">
        <property type="entry name" value="Tensin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000002">
        <property type="entry name" value="Tensin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1110:FF:000002">
        <property type="entry name" value="tensin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000010">
        <property type="entry name" value="tensin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035012">
        <property type="entry name" value="Tensin-like_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033929">
        <property type="entry name" value="Tensin_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF5">
        <property type="entry name" value="TENSIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="14">
        <location>
            <begin position="69"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="174"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="15">
        <location>
            <begin position="246"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="1241"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="433"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="699"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="817"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="963"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1160"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="434"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1180"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011869.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1514" mass="165331" checksum="A51D4714ACE4FDEA" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3P0</accession>
    <name>A0A5F8G3P0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein inturned</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">INTU</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inturned family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3P0"/>
    <dbReference type="Ensembl" id="ENSMODT00000086559.1">
        <property type="protein sequence ID" value="ENSMODP00000042051.1"/>
        <property type="gene ID" value="ENSMODG00000012120.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001301"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012120">
        <property type="expression patterns" value="Expressed in ovary and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043989">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043988">
        <property type="entry name" value="CCZ1/INTU_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039151">
        <property type="entry name" value="INTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21082">
        <property type="entry name" value="PROTEIN INTURNED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21082:SF4">
        <property type="entry name" value="PROTEIN INTURNED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19032">
        <property type="entry name" value="Intu_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19033">
        <property type="entry name" value="Intu_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="8">
        <location>
            <begin position="263"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU second Longin" evidence="9">
        <location>
            <begin position="472"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU/HPS4 third Longin" evidence="10">
        <location>
            <begin position="747"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="893" mass="99934" checksum="24872E84E2E99DAB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3P3</accession>
    <name>A0A5F8G3P3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">HCN2</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel HCN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3P3"/>
    <dbReference type="Ensembl" id="ENSMODT00000054397.1">
        <property type="protein sequence ID" value="ENSMODP00000042072.1"/>
        <property type="gene ID" value="ENSMODG00000006487.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156523"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006487">
        <property type="expression patterns" value="Expressed in cerebellum and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000031">
        <property type="entry name" value="Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000002">
        <property type="entry name" value="Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000007">
        <property type="entry name" value="Putative potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF11">
        <property type="entry name" value="POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0114">cAMP</keyword>
    <keyword evidence="7" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="19" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="16 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="25">
        <location>
            <begin position="386"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="575"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="717"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="740" mass="83160" checksum="2EE825EB97954821" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3P5</accession>
    <name>A0A5F8G3P5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WIZ zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">WIZ</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056678312.1">
        <property type="nucleotide sequence ID" value="XM_056822334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3P5"/>
    <dbReference type="Ensembl" id="ENSMODT00000085581.1">
        <property type="protein sequence ID" value="ENSMODP00000042056.1"/>
        <property type="gene ID" value="ENSMODG00000014589.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013188"/>
    <dbReference type="CTD" id="58525"/>
    <dbReference type="GeneTree" id="ENSGT00940000159979"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014589">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051643">
        <property type="entry name" value="Transcr_Reg_ZincFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055125">
        <property type="entry name" value="Wiz_C_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396:SF22">
        <property type="entry name" value="PROTEIN WIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23015">
        <property type="entry name" value="zf-WIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="660"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="865"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="938"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1022" mass="110491" checksum="89A6175924767DBD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3P6</accession>
    <name>A0A5F8G3P6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Maleylacetoacetate isomerase</fullName>
            <ecNumber evidence="6">2.5.1.18</ecNumber>
            <ecNumber evidence="7">5.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">GSTZ1-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glutathione S-transferase zeta 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GSTZ1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-maleylacetoacetate = 4-fumarylacetoacetate</text>
            <dbReference type="Rhea" id="RHEA:14817"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="EC" id="5.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 21">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="6"/>
    <dbReference type="EC" id="5.2.1.2" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3P6"/>
    <dbReference type="FunCoup" id="A0A5F8G3P6">
        <property type="interactions" value="1013"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042035"/>
    <dbReference type="Ensembl" id="ENSMODT00000085929.1">
        <property type="protein sequence ID" value="ENSMODP00000042035.1"/>
        <property type="gene ID" value="ENSMODG00000005427.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006580"/>
    <dbReference type="InParanoid" id="A0A5F8G3P6"/>
    <dbReference type="OMA" id="VYNAHRF"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005427">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03042">
        <property type="entry name" value="GST_N_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000041">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034333">
        <property type="entry name" value="GST_Zeta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="GST N-terminal" evidence="17">
        <location>
            <begin position="47"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="18">
        <location>
            <begin position="136"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="260" mass="28998" checksum="E941C7FF6B146A46" modified="2019-12-11" version="1">MSQSRRIPAPPHWLLCSTPLLTPPPTKQVLMEIFLFKGHKNNMAVPGKPILYSYFRSSCSWRVRIALALKGIDYDIVPINLVKDGGQQYSKEFETLNPMKQVPTLKIDGITITQSLAIIEYLEETRPTAPRLLPLDPKERASVRMISDLIASGIQPLQNLSILKKVGQETQLAWAQAVISSGFKALESVLQSTAGKYCLGNEISMADLCLVPQVANAERYKVDLSPYPTITRIYKTLLTVEAFQVSHPSRQPDTPPELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3P7</accession>
    <name>A0A5F8G3P7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ASXL transcriptional regulator 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ASXL3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asx family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000086656.1">
        <property type="protein sequence ID" value="ENSMODP00000042103.1"/>
        <property type="gene ID" value="ENSMODG00000010795.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00520000055578"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010795">
        <property type="expression patterns" value="Expressed in spermatocyte and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026905">
        <property type="entry name" value="ASX-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024811">
        <property type="entry name" value="ASX/ASX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578">
        <property type="entry name" value="ADDITIONAL SEX COMBS LIKE PROTEIN ASXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578:SF18">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN ASXL3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13922">
        <property type="entry name" value="PHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51913">
        <property type="entry name" value="HTH_HARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH HARE-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="12">
        <location>
            <begin position="255"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="157"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="554"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="607"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1436"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1574"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2024"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2142"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="612"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="690"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="731"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="840"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="886"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="945"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="958"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="983"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="2028"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2149"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="2159"/>
            <end position="2171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2271" mass="244353" checksum="8AC808F7CC8B520E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Q0</accession>
    <name>A0A5F8G3Q0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Eukaryotic translation initiation factor 4E type 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Eukaryotic translation initiation factor 4E-like 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">eIF4E-like protein 4E-LP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">EIF4E2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression. Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3. Does not interact with eIF4G (EIF4G1, EIF4G2 or EIF4G3). Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598. Interacts with GIGYF2 (via the 4EHP-binding motif); the interaction is direct. Interacts with EIF4ENIF1/4E-T (via YXXXXLphi motif); increasing affinity for the 7-methylguanosine-containing mRNA cap.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3Q0"/>
    <dbReference type="Ensembl" id="ENSMODT00000076943.1">
        <property type="protein sequence ID" value="ENSMODP00000042061.1"/>
        <property type="gene ID" value="ENSMODG00000002680.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154694"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002680">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E type 2 isoformX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF17">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 19" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 19" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="239" mass="27597" checksum="619EB31FDD70667E" modified="2019-12-11" version="1">MRPKLTSPDCLKDDDSGDHDQNEENNAQKDSEKERNERDRSQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKAWEEFHGLVNSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Q1</accession>
    <name>A0A5F8G3Q1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Centrosomal protein of 164 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CEP164</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts (via N-terminus) with ATRIP. Interacts with ATM, ATR and MDC1. Interacts with XPA (via N-terminus) upon UV irradiation. Interacts with CEP83, CCDC92, TTBK2, DVL3, NPHP3 and weakly with NPHP4. Interacts with DZIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000073634.1">
        <property type="protein sequence ID" value="ENSMODP00000042040.1"/>
        <property type="gene ID" value="ENSMODG00000013678.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183078"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013678">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097539">
        <property type="term" value="C:ciliary transition fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1470.10:FF:000001">
        <property type="entry name" value="Centrosomal protein of 164 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051841">
        <property type="entry name" value="MT-Golgi_org_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18902:SF27">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 164 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18902">
        <property type="entry name" value="NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="9 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="19">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="268"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="653"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="742"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="821"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="940"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="990"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1776"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1097"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1475"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1640"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="742"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="823"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="892"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="940"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1001"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1019"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1053"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1942" mass="217874" checksum="F3F51FA3861AAACD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Q4</accession>
    <name>A0A5F8G3Q4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Eukaryotic translation initiation factor 4E type 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Eukaryotic translation initiation factor 4E-like 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">eIF4E-like protein 4E-LP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">EIF4E2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression. Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3. Does not interact with eIF4G (EIF4G1, EIF4G2 or EIF4G3). Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598. Interacts with GIGYF2 (via the 4EHP-binding motif); the interaction is direct. Interacts with EIF4ENIF1/4E-T (via YXXXXLphi motif); increasing affinity for the 7-methylguanosine-containing mRNA cap.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3Q4"/>
    <dbReference type="Ensembl" id="ENSMODT00000086591.1">
        <property type="protein sequence ID" value="ENSMODP00000042082.1"/>
        <property type="gene ID" value="ENSMODG00000002680.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154694"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002680">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E type 2 isoformX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF17">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 19" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 19" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="237" mass="27404" checksum="12561848D1F23FB1" modified="2019-12-11" version="1">MRPKLTSPDCLKDDDSGDHDQNEENNAQKDSEKERNERDRSQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKDNSSFRNTKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Q5</accession>
    <name>A0A5F8G3Q5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pitrilysin metalloproteinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PITRM1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3Q5"/>
    <dbReference type="Ensembl" id="ENSMODT00000065124.1">
        <property type="protein sequence ID" value="ENSMODP00000042066.1"/>
        <property type="gene ID" value="ENSMODG00000006591.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018381"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006591">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000020">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000224">
        <property type="entry name" value="Pitrilysin metallepetidase 1 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="4">
        <location>
            <begin position="455"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="984" mass="112611" checksum="E0BE7CF2B4449CA9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Q7</accession>
    <name>A0A5F8G3Q7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 385C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZNF385C</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3Q7"/>
    <dbReference type="Ensembl" id="ENSMODT00000073402.1">
        <property type="protein sequence ID" value="ENSMODP00000042104.1"/>
        <property type="gene ID" value="ENSMODG00000014774.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157202"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014774">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051845">
        <property type="entry name" value="Znf385"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23067">
        <property type="entry name" value="DOUBLE-STRANDED RNA-BINDING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23067:SF6">
        <property type="entry name" value="ZINC FINGER PROTEIN 385C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="474" mass="50109" checksum="6D714DD8BFD495B2" modified="2019-12-11" version="1">MKRPLSPAPSGEKGLPALGGTECPPQPPEPSRPKRERKRPSYTLCDVCNIQLNSAAQAQVHCGGRAHQRRLRQLSSGKTPSGPGPASSSPNPLLASLPLPARPLQPPLDIKHFLTFHFNGAAPLSLFPNFSTMDPVQKAVISHTFGVPSPIKKKLFISCNICHLRFNSSNQAEAHYKGHKHARKLKAVEAAKSKQRTHTAGRDRATGPVTIPPDSRAPGEPQNKAPLAASPGSPLVLLKTLDPTPRESASLDLSDAASSSSSSSPSCSPSSPGPGAEMSGTRMGAGPGAASSASSDNRNEKGPLYCPTCKVTVNSASQLQAHNTGAKHKWMVDGHRGAPRRGRGRIMPRGGSGHKAKRVAGAPGGKPGPSPSFHCALCQLHVNSETQLKQHMSSRRHKDRLAGKPLKAKVSQHSKLQKHGALAVSILKSKLALQKQLTKTLAARFLPSPLPTAAMFPVGENKKRGGGVLVLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G400</accession>
    <name>A0A5F8G400_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZC3H14</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation. Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer; facilitating circular RNAs (circRNAs) formation. Associates with the spliceosome. Interacts with HOOK2. Interacts with ZFC3H1 in a RNase-sensitive manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G400"/>
    <dbReference type="Ensembl" id="ENSMODT00000084801.1">
        <property type="protein sequence ID" value="ENSMODP00000042168.1"/>
        <property type="gene ID" value="ENSMODG00000003282.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000038430"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003282">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000001">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000006">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 14 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000003">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 14 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="741" mass="83557" checksum="7E3C02FCBEF2AEF2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G402</accession>
    <name>A0A5F8G402_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000059653.1">
        <property type="protein sequence ID" value="ENSMODP00000042181.1"/>
        <property type="gene ID" value="ENSMODG00000010731.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154063"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010731">
        <property type="expression patterns" value="Expressed in liver and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006957">
        <property type="term" value="P:complement activation, alternative pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00017">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.130.20:FF:000001">
        <property type="entry name" value="Complement C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000155">
        <property type="entry name" value="complement C3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.91.20">
        <property type="entry name" value="Anaphylotoxins (complement system)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000020">
        <property type="entry name" value="Anaphylatoxin/fibulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018081">
        <property type="entry name" value="Anaphylatoxin_comp_syst"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041425">
        <property type="entry name" value="C3/4/5_MG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF81">
        <property type="entry name" value="COMPLEMENT C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01821">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17790">
        <property type="entry name" value="MG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00104">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47686">
        <property type="entry name" value="Anaphylotoxins (complement system)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01178">
        <property type="entry name" value="ANAPHYLATOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0179">Complement alternate pathway</keyword>
    <keyword evidence="4" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0882">Thioester bond</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023881674" evidence="9">
        <location>
            <begin position="20"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphylatoxin-like" evidence="10">
        <location>
            <begin position="628"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="11">
        <location>
            <begin position="1343"/>
            <end position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1506" mass="171234" checksum="2DD29249D4A49B3C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G403</accession>
    <name>A0A5F8G403_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Intraflagellar transport protein 88 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Tetratricopeptide repeat protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">IFT88</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Positively regulates primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT20, IFT22, IFT25, IFT27, IFT52, TRAF3IP1, IFT74, IFT80 and IFT81. Interacts with IFT172. Interacts with IFT57. Interacts with IFT46. Interacts with IFT70B. Interacts with C2CD3. Interacts with ENTR1 (via N-terminus). Interacts with LRRC56. Interacts with DZIP1. Interacts with CCDC38. Interacts with CCDC146. Interacts with CFAP53.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
            <location evidence="3">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007495264.1">
        <property type="nucleotide sequence ID" value="XM_007495202.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056650649.1">
        <property type="nucleotide sequence ID" value="XM_056794671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G403"/>
    <dbReference type="FunCoup" id="A0A5F8G403">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042155"/>
    <dbReference type="Ensembl" id="ENSMODT00000053710.1">
        <property type="protein sequence ID" value="ENSMODP00000042155.1"/>
        <property type="gene ID" value="ENSMODG00000008196.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100018534"/>
    <dbReference type="CTD" id="8100"/>
    <dbReference type="GeneTree" id="ENSGT00390000015473"/>
    <dbReference type="InParanoid" id="A0A5F8G403"/>
    <dbReference type="OMA" id="RIKIMHN"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008196">
        <property type="expression patterns" value="Expressed in ovary and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097542">
        <property type="term" value="C:ciliary tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000106">
        <property type="entry name" value="Intraflagellar transport 88 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000135">
        <property type="entry name" value="intraflagellar transport protein 88 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 16" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="519"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="587"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="725"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="765"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="765"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="820"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="832"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="847" mass="96026" checksum="176E094B25CBD5C9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G404</accession>
    <name>A0A5F8G404_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VPS26 retromer complex component A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">VPS26A</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007505936.1">
        <property type="nucleotide sequence ID" value="XM_007505874.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G404"/>
    <dbReference type="Ensembl" id="ENSMODT00000071987.1">
        <property type="protein sequence ID" value="ENSMODP00000042173.1"/>
        <property type="gene ID" value="ENSMODG00000010661.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100031336"/>
    <dbReference type="CTD" id="9559"/>
    <dbReference type="GeneTree" id="ENSGT00950000183064"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010661">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="362" mass="41697" checksum="0F0DC828EE999AA1" modified="2019-12-11" version="1">MAGPPLPFPGRFWAPWLPVGSSPLRALLTAAAASPKSFLGGFFGPICEIDVVLNDGESRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLSDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKPRTNFHQRFEPPEPQASAEQPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G405</accession>
    <name>A0A5F8G405_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein EFR3 homolog A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein EFR3-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EFR3A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3A probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G405"/>
    <dbReference type="Ensembl" id="ENSMODT00000079825.1">
        <property type="protein sequence ID" value="ENSMODP00000042186.1"/>
        <property type="gene ID" value="ENSMODG00000001307.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001307">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000347">
        <property type="entry name" value="EFR3 homolog A (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF1">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="690" mass="78403" checksum="69626CEEC5307A87" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G406</accession>
    <name>A0A5F8G406_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec1 family domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SCFD1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G406"/>
    <dbReference type="Ensembl" id="ENSMODT00000052245.1">
        <property type="protein sequence ID" value="ENSMODP00000042202.1"/>
        <property type="gene ID" value="ENSMODG00000017563.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074845"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017563">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.60:FF:000002">
        <property type="entry name" value="Sec1 family domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="576" mass="65457" checksum="47FD7334CFB4C085" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G411</accession>
    <name>A0A5F8G411_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acidic leucine-rich nuclear phosphoprotein 32 family member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Multifunctional protein that is involved in the regulation of many processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the ANP32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G411"/>
    <dbReference type="Ensembl" id="ENSMODT00000053901.1">
        <property type="protein sequence ID" value="ENSMODP00000042207.1"/>
        <property type="gene ID" value="ENSMODG00000003629.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182907"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003629">
        <property type="expression patterns" value="Expressed in hindlimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF22">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="240" mass="27286" checksum="D1CFD57F53C0E9D5" modified="2019-12-11" version="1">MDIKRRLTLELRNRKPGEVRPDLVLDNCSSEDGKIGGLSSEFENLEFLSMISINLVSLANLPKLPRLQKLELSDNLISGGLELNLSRNKIKDINTLEPLKKLPNLKSLDLFNCDVTMLMSYRESVFGLLPQLTYLDGYSADDKEAPDSDPEADREGLDSVCGENGEEEEEEEEEEEELDEDVIDDEDDEDDEDDEDEDVDGEEEEEEEEEEEDEEEDGIEDEVRKKLALCCLFSPERGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G412</accession>
    <name>A0A5F8G412_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cilia and flagella associated protein 69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CFAP69</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G412"/>
    <dbReference type="Ensembl" id="ENSMODT00000062992.1">
        <property type="protein sequence ID" value="ENSMODP00000042165.1"/>
        <property type="gene ID" value="ENSMODG00000010440.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014274"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010440">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000863">
        <property type="entry name" value="cilia- and flagella-associated protein 69 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048732">
        <property type="entry name" value="CFA69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048733">
        <property type="entry name" value="CFA69_ARM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14716">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14716:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21049">
        <property type="entry name" value="CFA69_ARM_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 69 ARM repeats" evidence="2">
        <location>
            <begin position="98"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="910" mass="102620" checksum="7DC33294185974FC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G413</accession>
    <name>A0A5F8G413_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Arachidonate 12-lipoxygenase, 12S type</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="10">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lipoxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G413"/>
    <dbReference type="Ensembl" id="ENSMODT00000053902.1">
        <property type="protein sequence ID" value="ENSMODP00000042196.1"/>
        <property type="gene ID" value="ENSMODG00000025681.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155191"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025681">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.245.10:FF:000001">
        <property type="entry name" value="Arachidonate 5-lipoxygenase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001885">
        <property type="entry name" value="LipOase_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00467">
        <property type="entry name" value="MAMLPOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="14">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="15">
        <location>
            <begin position="109"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Essential for stabilizing binding to COTL1" evidence="12">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601885-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601885-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601885-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="75546" checksum="0DE1E78F79C5726F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G414</accession>
    <name>A0A5F8G414_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ENO4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G414"/>
    <dbReference type="Ensembl" id="ENSMODT00000088003.1">
        <property type="protein sequence ID" value="ENSMODP00000042212.1"/>
        <property type="gene ID" value="ENSMODG00000009486.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182805"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009486">
        <property type="expression patterns" value="Expressed in spermatocyte and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF30">
        <property type="entry name" value="ENOLASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="9">
        <location>
            <begin position="47"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="8">
        <location>
            <begin position="227"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="576" mass="62801" checksum="D4E12C574E4CB03E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G416</accession>
    <name>A0A5F8G416_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Eyes absent homolog</fullName>
            <ecNumber evidence="21">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">EYA3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 25">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="20 21">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the HAD-like hydrolase superfamily. EYA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="21"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G416"/>
    <dbReference type="FunCoup" id="A0A5F8G416">
        <property type="interactions" value="2734"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042201"/>
    <dbReference type="Ensembl" id="ENSMODT00000083915.1">
        <property type="protein sequence ID" value="ENSMODP00000042201.1"/>
        <property type="gene ID" value="ENSMODG00000010782.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182978"/>
    <dbReference type="InParanoid" id="A0A5F8G416"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010782">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140793">
        <property type="term" value="F:histone H2AXY142 phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02601">
        <property type="entry name" value="HAD_Eya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12350:FF:000002">
        <property type="entry name" value="Eyes absent homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028472">
        <property type="entry name" value="EYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006545">
        <property type="entry name" value="EYA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042577">
        <property type="entry name" value="EYA_dom_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038102">
        <property type="entry name" value="EYA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01658">
        <property type="entry name" value="EYA-cons_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190">
        <property type="entry name" value="EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190:SF5">
        <property type="entry name" value="EYES ABSENT HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 20 21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 21" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13 21" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="251"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="590"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="19">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="19">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="638" mass="69136" checksum="76610AC35DF72627" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G417</accession>
    <name>A0A5F8G417_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">6-phosphofructokinase type B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphofructo-1-kinase isozyme B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PFKL</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G417"/>
    <dbReference type="Ensembl" id="ENSMODT00000069218.1">
        <property type="protein sequence ID" value="ENSMODP00000042193.1"/>
        <property type="gene ID" value="ENSMODG00000003119.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159292"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003119">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000001">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000003">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF14">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="20">
        <location>
            <begin position="55"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="20">
        <location>
            <begin position="307"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="685" mass="75058" checksum="D8DD03124F74229A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G419</accession>
    <name>A0A5F8G419_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ral GTPase activating protein catalytic subunit alpha 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RALGAPA1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000079641.1">
        <property type="protein sequence ID" value="ENSMODP00000042189.1"/>
        <property type="gene ID" value="ENSMODG00000012779.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183139"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012779">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF3">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="2234"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="804"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1317"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1428"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2486"/>
            <end position="2521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1334"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1428"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2503"/>
            <end position="2513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2521" mass="283805" checksum="2544A92D82622617" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G420</accession>
    <name>A0A5F8G420_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100029348</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G420"/>
    <dbReference type="Ensembl" id="ENSMODT00000080577.1">
        <property type="protein sequence ID" value="ENSMODP00000042206.1"/>
        <property type="gene ID" value="ENSMODG00000010055.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163734"/>
    <dbReference type="OMA" id="FRENDTQ"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010055">
        <property type="expression patterns" value="Expressed in cerebellum and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000037">
        <property type="entry name" value="kinesin-like protein KIF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF69">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 13 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="33"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="806"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="536"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="975" mass="110422" checksum="626218C03BB2675E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G421</accession>
    <name>A0A5F8G421_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Odontogenic ameloblast-associated protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Apin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts (via C-terminus) with ARHGEF5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ODAM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G421"/>
    <dbReference type="Ensembl" id="ENSMODT00000059800.1">
        <property type="protein sequence ID" value="ENSMODP00000042198.1"/>
        <property type="gene ID" value="ENSMODG00000028253.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011100"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000028253">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031214">
        <property type="term" value="P:biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026802">
        <property type="entry name" value="Odam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16237">
        <property type="entry name" value="ODONTOGENIC AMELOBLAST-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16237:SF3">
        <property type="entry name" value="ODONTOGENIC AMELOBLAST-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15424">
        <property type="entry name" value="ODAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0091">Biomineralization</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023804935" description="Odontogenic ameloblast-associated protein" evidence="15">
        <location>
            <begin position="16"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="248" mass="26902" checksum="66BD4501ABF5B342" modified="2019-12-11" version="1">MRAAILLGFLGVALAAPLLPQPLLSASNSRELLMGLGNARLRGLPPGLQASANPLIFPLPGALHHGPRPLGLSWPSLGHFGGLVPNEVPLPGQARLAQRSQAVQQEAPRLQMLQQNQQDPYQIIPCFFSFGVPQVWGQMVPYYPVCVYGAQDPPLQLSALAGPPQPPEQVPSYPELGCLTQQAQPPIENVLPYTQREMVNLGYPYAGIFMPSYPLKHQTANILASPTDNVVPLELLEEEINPDLLKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G424</accession>
    <name>A0A5F8G424_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DEAD box protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DDX4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Interacts with RANBP9. Interacts with RANBP10. Interacts with PIWIL2 and MAEL. Interacts with BMAL1 and CLOCK. Interacts with Tex19.1 and, probably, Tex19.2. Interacts with RBM46.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX4/VASA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G424"/>
    <dbReference type="Ensembl" id="ENSMODT00000053485.1">
        <property type="protein sequence ID" value="ENSMODP00000042194.1"/>
        <property type="gene ID" value="ENSMODG00000019511.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157507"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019511">
        <property type="expression patterns" value="Expressed in spermatocyte and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18052">
        <property type="entry name" value="DEADc_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="303"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="514"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="30"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="712" mass="78208" checksum="6159FC7E957BB1D5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G425</accession>
    <name>A0A5F8G425_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum membrane sensor NFE2L1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Nuclear factor erythroid 2-related factor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Nuclear factor, erythroid derived 2, like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">NFE2L1</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type III membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. CNC subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G425"/>
    <dbReference type="Ensembl" id="ENSMODT00000070685.1">
        <property type="protein sequence ID" value="ENSMODP00000042211.1"/>
        <property type="gene ID" value="ENSMODG00000012375.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182892"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012375">
        <property type="expression patterns" value="Expressed in heart and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14720">
        <property type="entry name" value="bZIP_NFE2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.880.10:FF:000001">
        <property type="entry name" value="Nuclear factor erythroid 2-related factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF31">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE SENSOR NFE2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="21" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BZIP" evidence="27">
        <location>
            <begin position="461"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="284"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="479"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00030985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00031659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="579" mass="64008" checksum="EDFC7CE3F989681D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G427</accession>
    <name>A0A5F8G427_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic polyadenylation element binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CPEB2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPEB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G427"/>
    <dbReference type="Ensembl" id="ENSMODT00000088416.1">
        <property type="protein sequence ID" value="ENSMODP00000042180.1"/>
        <property type="gene ID" value="ENSMODG00000001149.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160357"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001149">
        <property type="expression patterns" value="Expressed in spermatocyte and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12724">
        <property type="entry name" value="RRM1_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12726">
        <property type="entry name" value="RRM2_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000008">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000009">
        <property type="entry name" value="cytoplasmic polyadenylation element-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF8">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="698"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="806"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="929" mass="100073" checksum="6CF292550C6A2185" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUQ9</accession>
    <name>A0A5F8GUQ9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pleckstrin homology, MyTH4 and FERM domain containing H1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PLEKHH1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUQ9"/>
    <dbReference type="Ensembl" id="ENSMODT00000085953.1">
        <property type="protein sequence ID" value="ENSMODP00000050946.1"/>
        <property type="gene ID" value="ENSMODG00000009952.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159456"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009952">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13282">
        <property type="entry name" value="PH1_PLEKHH1_PLEKHH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903:SF4">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903">
        <property type="entry name" value="PLEKHH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="490"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="6">
        <location>
            <begin position="745"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="5">
        <location>
            <begin position="910"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1274" mass="142943" checksum="380F38C836ED3591" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUR0</accession>
    <name>A0A5F8GUR0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ADAMTS like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ADAMTSL1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000088223.1">
        <property type="protein sequence ID" value="ENSMODP00000051094.1"/>
        <property type="gene ID" value="ENSMODG00000014683.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156243"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014683">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000011">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000025">
        <property type="entry name" value="ADAMTS like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000002">
        <property type="entry name" value="ADAMTS like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001073">
        <property type="entry name" value="ADAMTS like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000016">
        <property type="entry name" value="ADAMTS-like 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000487">
        <property type="entry name" value="ADAMTS-like 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000009">
        <property type="entry name" value="ADAMTS-like protein 3 isoform A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056272">
        <property type="entry name" value="ADAMTSL1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF157">
        <property type="entry name" value="ADAMTS-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24484">
        <property type="entry name" value="ADAMTSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="962"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1267"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1389"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1498"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="11">
        <location>
            <begin position="1829"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1074"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1865" mass="208508" checksum="644DD99BFC330BCA" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUR1</accession>
    <name>A0A5F8GUR1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ICOS ligand</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">B7 homolog 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">B7-like protein Gl50</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">B7-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC100027399</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. BTN/MOG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUR1"/>
    <dbReference type="Ensembl" id="ENSMODT00000064571.1">
        <property type="protein sequence ID" value="ENSMODP00000051237.1"/>
        <property type="gene ID" value="ENSMODG00000029138.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161590"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000029138">
        <property type="expression patterns" value="Expressed in liver and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042113">
        <property type="term" value="P:B cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042104">
        <property type="term" value="P:positive regulation of activated T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001912">
        <property type="entry name" value="CD274 molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000996">
        <property type="entry name" value="ICOS ligand isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF151">
        <property type="entry name" value="ICOS LIGAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="7" id="KW-0075">B-cell activation</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023878536" description="ICOS ligand" evidence="19">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="148"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="292" mass="32951" checksum="E79183845D3C8101" modified="2019-12-11" version="1">MSLKRTECLLLFLAALRAVIMKEIHGMVGDNVELSCISPIQRHFDLQNIHVYWQTTKTPPESVKSYIPGENSSQYDDSKYKNRASLTPEKMERGDFSLLLSNITTKDEQEFVCIVLNKSSFGILLQSEVTLRVAANFSVPVVAQETNNTEVTFTCTSHNGFPEPKVYWVNKTDNSLLNHTLQTVTKNEKGLFSVYSVLTIEWTPNISIECCIENVNLQQNLTVWKGFLPSLGGNTGQLKFTTIPNEPRPPETTSNTALFIIIGILFVVLVAAIISRQLCKKRHHYGHYTDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUR3</accession>
    <name>A0A5F8GUR3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphoinositide-3-kinase regulatory subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PIK3R1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3K p85 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007486475.1">
        <property type="nucleotide sequence ID" value="XM_007486413.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUR3"/>
    <dbReference type="Ensembl" id="ENSMODT00000061242.1">
        <property type="protein sequence ID" value="ENSMODP00000051285.1"/>
        <property type="gene ID" value="ENSMODG00000019685.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100019317"/>
    <dbReference type="CTD" id="5295"/>
    <dbReference type="GeneTree" id="ENSGT00940000155553"/>
    <dbReference type="OrthoDB" id="3175255at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019685">
        <property type="expression patterns" value="Expressed in uterine wall and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd12924">
        <property type="entry name" value="iSH2_PIK3R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09930">
        <property type="entry name" value="SH2_cSH2_p85_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09942">
        <property type="entry name" value="SH2_nSH2_p85_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000006">
        <property type="entry name" value="Phosphatidylinositol 3-kinase regulatory subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 3-kinase regulatory subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1490:FF:000001">
        <property type="entry name" value="Putative phosphatidylinositol 3-kinase regulatory subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044124">
        <property type="entry name" value="ISH2_PIK3R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032498">
        <property type="entry name" value="PI3K_P85_iSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035020">
        <property type="entry name" value="PI3kinase_P85_cSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035022">
        <property type="entry name" value="PI3kinase_P85_nSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16454">
        <property type="entry name" value="PI3K_P85_iSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00678">
        <property type="entry name" value="PI3KINASEP85"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="111"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="402"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="292"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="502" mass="59259" checksum="24003753179C813D" modified="2019-12-11" version="1">MFLPFPSGFSGTLIESGRIPLQGNFSTRPLNWFRLDRNQFMIQLGEAWGLFIFSWWENNFVDFSNCWIQEFQRKTFAMHNLQTLPPKPPKPTTVTANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDSIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIVDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSMVEDDEDLPHHDERTWNVGSSNRSKAENLLRGKRDGTFLVRESSKQGCFACSVVVDGEVKHCVINKTPTGYGFAEPYNLYNSLKELVLHYQHTSLVQHNDSLNVTLAYPVNAQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUR4</accession>
    <name>A0A5F8GUR4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chymotrypsin C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CTRC</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUR4"/>
    <dbReference type="Ensembl" id="ENSMODT00000055656.1">
        <property type="protein sequence ID" value="ENSMODP00000050951.1"/>
        <property type="gene ID" value="ENSMODG00000027369.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153216"/>
    <dbReference type="OMA" id="GAWAHTC"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000027369">
        <property type="expression patterns" value="Expressed in blood and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000004">
        <property type="entry name" value="Tryptase gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050850">
        <property type="entry name" value="Peptidase_S1_Elastase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24257">
        <property type="entry name" value="CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24257:SF31">
        <property type="entry name" value="ELASTASE 3 LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023857151" evidence="2">
        <location>
            <begin position="17"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="30"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="222" mass="24194" checksum="1E5E78426F500497" modified="2019-12-11" version="1">MLGSVLLIAFLGYASSCGVPTYMPNLANRVVGGEDVRPHSWPWQVSLQYLKDDTFRHTCGGSLISSQHVLTAAHCISKDKTYRVLLGKNNLVEEEADAVAAAVDTIFVHEKWNSFLVRNDIALIKLAEPVELSDTIQVACLPPEGSLLAHDYPCYVTGWGRLWTNGPIADNLQQGFLPIVDHTTCTKSDWWGSMVTQKMVCAGGDGVISACNCSTQLSTSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUR8</accession>
    <name>A0A5F8GUR8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mortality factor 4 like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MORF4L1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUR8"/>
    <dbReference type="Ensembl" id="ENSMODT00000071546.1">
        <property type="protein sequence ID" value="ENSMODP00000051290.1"/>
        <property type="gene ID" value="ENSMODG00000011517.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182965"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011517">
        <property type="expression patterns" value="Expressed in ovary and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000001">
        <property type="entry name" value="Mortality factor 4-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF48">
        <property type="entry name" value="MORTALITY FACTOR 4 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MRG" evidence="10">
        <location>
            <begin position="221"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="408" mass="46452" checksum="4E059ADE42344B97" modified="2019-12-11" version="1">MPRRGSRAALRVRWDMRVRTHCSPWRGRARDSSCCGACGRLANQAGGGAGRDAQLGGVQGGGGGGGSGGDYDGGRRRRSGRRRRRVVHKWRRSRTRSPNSRRVNVYCVFMDHSFMKQSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEALFQNRWITRCLETSAISMRKTKKNKQKTPGIGEGSSTSETPQPPRKKRARVDPTVESEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYASYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSSALFSASDYEVAPPEYHRKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUR9</accession>
    <name>A0A5F8GUR9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYC binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MYCBP</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUR9"/>
    <dbReference type="Ensembl" id="ENSMODT00000058554.1">
        <property type="protein sequence ID" value="ENSMODP00000051104.1"/>
        <property type="gene ID" value="ENSMODG00000038621.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017974"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000038621">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="56" mass="6630" checksum="2E25C4C249D32AED" modified="2019-12-11" version="1">MAHYKAADSKREQFRRYLEKSGVLDTLTKASLRSFNSRKSRNRVASRRTGRDKREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUS2</accession>
    <name>A0A5F8GUS2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Utrophin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">UTRN</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Cytoplasm</location>
            <location evidence="1 16">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Postsynapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000060988.1">
        <property type="protein sequence ID" value="ENSMODP00000051383.1"/>
        <property type="gene ID" value="ENSMODG00000017210.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153467"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017210">
        <property type="expression patterns" value="Expressed in uterus and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21234">
        <property type="entry name" value="CH_UTRN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16247">
        <property type="entry name" value="EFh_UTRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000118">
        <property type="entry name" value="Dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000008">
        <property type="entry name" value="Dystrophin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000001">
        <property type="entry name" value="Dystrophin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000023">
        <property type="entry name" value="dystrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000140">
        <property type="entry name" value="dystrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000004">
        <property type="entry name" value="dystrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000091">
        <property type="entry name" value="dystrophin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000032">
        <property type="entry name" value="utrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000029">
        <property type="entry name" value="utrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000056">
        <property type="entry name" value="utrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000070">
        <property type="entry name" value="utrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000075">
        <property type="entry name" value="utrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000102">
        <property type="entry name" value="utrophin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035436">
        <property type="entry name" value="Dystrophin/utrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF26">
        <property type="entry name" value="UTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002341">
        <property type="entry name" value="Dystrophin/utrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 16" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 16" id="KW-0770">Synapse</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="21">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="21">
        <location>
            <begin position="95"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="20">
        <location>
            <begin position="2242"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="22">
        <location>
            <begin position="2495"/>
            <end position="2551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="989"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="710"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1280"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="2116"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="2658"/>
            <end position="2692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="2731"/>
            <end position="2765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR002341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2867" mass="330662" checksum="F89C440EB063075C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUS3</accession>
    <name>A0A5F8GUS3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUS3"/>
    <dbReference type="Ensembl" id="ENSMODT00000081909.1">
        <property type="protein sequence ID" value="ENSMODP00000051295.1"/>
        <property type="gene ID" value="ENSMODG00000025255.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154838"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025255">
        <property type="expression patterns" value="Expressed in blood and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01469">
        <property type="entry name" value="vWA_integrins_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048633">
        <property type="entry name" value="ITGAX-like_Ig_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF118">
        <property type="entry name" value="INTEGRIN ALPHA-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00357">
        <property type="entry name" value="Integrin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21520">
        <property type="entry name" value="ITGAX-like_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0401">Integrin</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1095"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="17">
        <location>
            <begin position="147"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="436"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="499"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="562"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1147" mass="126849" checksum="DC0BA84429CE1DFE" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUS5</accession>
    <name>A0A5F8GUS5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">CLCN3</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUS5"/>
    <dbReference type="Ensembl" id="ENSMODT00000056683.1">
        <property type="protein sequence ID" value="ENSMODP00000050961.1"/>
        <property type="gene ID" value="ENSMODG00000003024.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153763"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003024">
        <property type="expression patterns" value="Expressed in spinal cord and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062158">
        <property type="term" value="F:chloride:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1280.20:FF:000001">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1280.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002245">
        <property type="entry name" value="ClC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF8">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01114">
        <property type="entry name" value="CLCHANNEL3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0050">Antiport</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 22" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19 23" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 23" id="KW-0406">Ion transport</keyword>
    <keyword evidence="20" id="KW-0458">Lysosome</keyword>
    <keyword evidence="17 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 23" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="24">
        <location>
            <begin position="639"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="24">
        <location>
            <begin position="736"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="799" mass="89092" checksum="B184FFED2D6F3F28" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUS6</accession>
    <name>A0A5F8GUS6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protocadherin gamma-C5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PCDHGC5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUS6"/>
    <dbReference type="FunCoup" id="A0A5F8GUS6">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000061740.1">
        <property type="protein sequence ID" value="ENSMODP00000051252.1"/>
        <property type="gene ID" value="ENSMODG00000010717.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162232"/>
    <dbReference type="InParanoid" id="A0A5F8GUS6"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010717">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000216">
        <property type="entry name" value="protocadherin gamma-C5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032455">
        <property type="entry name" value="Cadherin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031904">
        <property type="entry name" value="Cadherin_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF349">
        <property type="entry name" value="PROTOCADHERIN GAMMA-C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16492">
        <property type="entry name" value="Cadherin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15974">
        <property type="entry name" value="Cadherin_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="134"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="243"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="359"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="455"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="571"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="807"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="914"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="929"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="939" mass="101832" checksum="62F48FDE8738331D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUS8</accession>
    <name>A0A5F8GUS8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Zinc finger protein 420-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100010922</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUS8"/>
    <dbReference type="Ensembl" id="ENSMODT00000060664.1">
        <property type="protein sequence ID" value="ENSMODP00000051300.1"/>
        <property type="gene ID" value="ENSMODG00000041775.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161954"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000041775">
        <property type="expression patterns" value="Expressed in ovary and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001984">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001530">
        <property type="entry name" value="Zinc finger protein 268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000801">
        <property type="entry name" value="zinc finger protein 461 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002134">
        <property type="entry name" value="Zinc finger protein 616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001157">
        <property type="entry name" value="Zinc finger protein 793"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000057">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="17">
        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="514" mass="59986" checksum="EF0E71FCA27CC65D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUS9</accession>
    <name>A0A5F8GUS9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrator complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">INTS10</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the Integrator complex, composed of core subunits INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L, INTS12, INTS13, INTS14 and INTS15. The core complex associates with protein phosphatase 2A subunits PPP2CA and PPP2R1A, to form the Integrator-PP2A (INTAC) complex. INTS10 is part of the tail subcomplex, composed of INTS10, INTS13, INTS14 and INTS15.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056669607.1">
        <property type="nucleotide sequence ID" value="XM_056813629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUS9"/>
    <dbReference type="Ensembl" id="ENSMODT00000078492.1">
        <property type="protein sequence ID" value="ENSMODP00000050966.1"/>
        <property type="gene ID" value="ENSMODG00000009962.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100030298"/>
    <dbReference type="CTD" id="55174"/>
    <dbReference type="GeneTree" id="ENSGT00390000010950"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009962">
        <property type="expression patterns" value="Expressed in hindlimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026164">
        <property type="entry name" value="Int_cplx_su10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16055">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16055:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21045">
        <property type="entry name" value="INT10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02106">
        <property type="entry name" value="INTSUBUNIT10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="773" mass="88289" checksum="AA2D7BA745C77C25" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUT0</accession>
    <name>A0A5F8GUT0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock transcription factor 2 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HSF2BP</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUT0"/>
    <dbReference type="Ensembl" id="ENSMODT00000085366.1">
        <property type="protein sequence ID" value="ENSMODP00000051114.1"/>
        <property type="gene ID" value="ENSMODG00000021032.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008490"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021032">
        <property type="expression patterns" value="Expressed in testis and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039584">
        <property type="entry name" value="HSF2BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15434">
        <property type="entry name" value="HEAT SHOCK FACTOR 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15434:SF2">
        <property type="entry name" value="HEAT SHOCK FACTOR 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="304" mass="34586" checksum="D5A5B3A2838A11F9" modified="2019-12-11" version="1">MCITLPQMYFLETTYSRILVFNPLYYPFCFMGLEKKEQEVEQMRMDCEHFRARLEIAQADSIKEKKEKLALRQQLNELKEQLLQQAEYCTEMGAATCTLLWSVSSSEEVVKAILGGGKALKFFNLTGQTMESFVRSLDGNSKQELDSDENQFVFALAGILTNVAAIACGREFLVNSSRVLLDTTMQLLGDLKPGQCTKLKVLMLMTLYNVSINLKGLKYISESPSFVPLLSWLLKDPDPEVCLHVLRLVQSVVLETEVFSKLASQFHDSMFLQHIITISKSQNFSLRTLAQELLEDFKVLEFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUT1</accession>
    <name>A0A5F8GUT1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 19">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ZC3H14</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation. Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homodimer; facilitating circular RNAs (circRNAs) formation. Associates with the spliceosome. Interacts with HOOK2. Interacts with ZFC3H1 in a RNase-sensitive manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007472714.1">
        <property type="nucleotide sequence ID" value="XM_007472652.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUT1"/>
    <dbReference type="Ensembl" id="ENSMODT00000075461.1">
        <property type="protein sequence ID" value="ENSMODP00000051257.1"/>
        <property type="gene ID" value="ENSMODG00000003282.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100019205"/>
    <dbReference type="KEGG" id="mdo:100019205"/>
    <dbReference type="CTD" id="79882"/>
    <dbReference type="GeneTree" id="ENSGT00440000038430"/>
    <dbReference type="OrthoDB" id="5589010at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003282">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.10:FF:000006">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000001">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000006">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 14 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000003">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 14 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="21">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="18">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="77"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU369058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="740" mass="83459" checksum="76927EEA104E33AE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUT2</accession>
    <name>A0A5F8GUT2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase AMP-activated non-catalytic subunit gamma 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PRKAG2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUT2"/>
    <dbReference type="Ensembl" id="ENSMODT00000087815.1">
        <property type="protein sequence ID" value="ENSMODP00000051393.1"/>
        <property type="gene ID" value="ENSMODG00000004614.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183019"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004614">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000003">
        <property type="entry name" value="Protein kinase AMP-activated non-catalytic subunit gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF122">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="321"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="394"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="468"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="533" mass="58351" checksum="C7BEFBBAB9075533" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUT8</accession>
    <name>A0A5F8GUT8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAC-A/B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000088853.1">
        <property type="protein sequence ID" value="ENSMODP00000051310.1"/>
        <property type="gene ID" value="ENSMODG00000010591.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161501"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010591">
        <property type="expression patterns" value="Expressed in cerebellum and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14416">
        <property type="entry name" value="UBA_NACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041907">
        <property type="entry name" value="NACAD_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="1651"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1558"/>
            <end position="1569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1796" mass="189695" checksum="CAB372641E13F96B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV31</accession>
    <name>A0A5F8GV31_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fibronectin type-III domain-containing protein 3A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FNDC3A</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Mediates spermatid-Sertoli adhesion during spermatogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FNDC3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV31"/>
    <dbReference type="Ensembl" id="ENSMODT00000058814.1">
        <property type="protein sequence ID" value="ENSMODP00000051400.1"/>
        <property type="gene ID" value="ENSMODG00000011079.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159319"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011079">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000175">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000180">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000185">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000195">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000210">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000309">
        <property type="entry name" value="Fibronectin type III domain containing 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000366">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000373">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000337">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1123"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="217"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="322"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="418"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="515"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="613"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="710"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="812"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="900"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1147" mass="126648" checksum="E237339B41C5A836" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV32</accession>
    <name>A0A5F8GV32_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MAP7 domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MAP7D2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAP7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007493504.1">
        <property type="nucleotide sequence ID" value="XM_007493442.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV32"/>
    <dbReference type="Ensembl" id="ENSMODT00000083860.1">
        <property type="protein sequence ID" value="ENSMODP00000051071.1"/>
        <property type="gene ID" value="ENSMODG00000008158.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013729"/>
    <dbReference type="KEGG" id="mdo:100013729"/>
    <dbReference type="CTD" id="256714"/>
    <dbReference type="GeneTree" id="ENSGT00950000182941"/>
    <dbReference type="OrthoDB" id="9950098at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008158">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008604">
        <property type="entry name" value="MAP7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF3">
        <property type="entry name" value="MAP7 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05672">
        <property type="entry name" value="MAP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="768" mass="86669" checksum="DC13A7258D8F746E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV37</accession>
    <name>A0A5F8GV37_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Endosome-lysosome associated apoptosis and autophagy regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ELAPOR1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELAPOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV37"/>
    <dbReference type="Ensembl" id="ENSMODT00000086977.1">
        <property type="protein sequence ID" value="ENSMODP00000051362.1"/>
        <property type="gene ID" value="ENSMODG00000002182.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156861"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002182">
        <property type="expression patterns" value="Expressed in spermatocyte and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056609">
        <property type="entry name" value="Elapor1-like_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039181">
        <property type="entry name" value="Elapor1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056606">
        <property type="entry name" value="Elapor1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056608">
        <property type="entry name" value="Elapor1/2_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056607">
        <property type="entry name" value="Elapor1/2_MRH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056610">
        <property type="entry name" value="Elapor1/2_TNFR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727:SF13">
        <property type="entry name" value="ENDOSOME_LYSOSOME-ASSOCIATED APOPTOSIS AND AUTOPHAGY REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727">
        <property type="entry name" value="PROTEIN CBG13728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23089">
        <property type="entry name" value="ELAPOR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23031">
        <property type="entry name" value="GBD_ELAPOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23032">
        <property type="entry name" value="GBD_ELAPOR1-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23087">
        <property type="entry name" value="MRH_ELAPOR1_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23091">
        <property type="entry name" value="TNFR_ELAPOR1_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023905726" evidence="11">
        <location>
            <begin position="38"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="12">
        <location>
            <begin position="569"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="924" mass="101626" checksum="830F546F065E4E13" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV38</accession>
    <name>A0A5F8GV38_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MET proto-onco, receptor tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MET</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV38"/>
    <dbReference type="Ensembl" id="ENSMODT00000064107.1">
        <property type="protein sequence ID" value="ENSMODP00000051488.1"/>
        <property type="gene ID" value="ENSMODG00000015822.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158022"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015822">
        <property type="expression patterns" value="Expressed in uterine wall and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01180">
        <property type="entry name" value="IPT_plexin_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01179">
        <property type="entry name" value="IPT_plexin_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000088">
        <property type="entry name" value="Hepatocyte growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000213">
        <property type="entry name" value="Hepatocyte growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000400">
        <property type="entry name" value="Hepatocyte growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000006">
        <property type="entry name" value="Macrophage-stimulating 1 receptor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF61">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023866685" evidence="11">
        <location>
            <begin position="25"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="12">
        <location>
            <begin position="27"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="762" mass="85485" checksum="81AC24EF51DBB97A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV39</accession>
    <name>A0A5F8GV39_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV39"/>
    <dbReference type="Ensembl" id="ENSMODT00000074804.1">
        <property type="protein sequence ID" value="ENSMODP00000051234.1"/>
        <property type="gene ID" value="ENSMODG00000051438.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154679"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000003">
        <property type="entry name" value="Glutathione S-transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF133">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE MU 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutathione S-transferase C-terminal" evidence="4">
        <location>
            <begin position="107"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="211" mass="24669" checksum="19D96C4122E4D241" modified="2019-12-11" version="1">KISTQGYYLDLHMGNTIRVLYLELAKGSLYSPSEWLSDPPPPLHYHLWLRDSEVFAADLDTPKAYCCNEPCLSKLCVTILHYIAQKYNLCSEMEEEHIQVDVLENHIMDIQMQLVHVCYNPNFEIIKIECLHQLPGQLKLFSLFLGKCTWFAGNKITYVDFLKFLKLKEFLHWFESLSSISTYLAFEHCQLYPIFTKMACWGNPKFALFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV42</accession>
    <name>A0A5F8GV42_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EDEM1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV42"/>
    <dbReference type="Ensembl" id="ENSMODT00000074518.1">
        <property type="protein sequence ID" value="ENSMODP00000051367.1"/>
        <property type="gene ID" value="ENSMODG00000004556.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157717"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004556">
        <property type="expression patterns" value="Expressed in endometrium and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904154">
        <property type="term" value="P:positive regulation of retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000016">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0834">Unfolded protein response</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="604" mass="68194" checksum="356ACAE1EA8CD173" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV46</accession>
    <name>A0A5F8GV46_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Shootin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SHTN1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the shootin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007478994.1">
        <property type="nucleotide sequence ID" value="XM_007478932.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV46"/>
    <dbReference type="Ensembl" id="ENSMODT00000061997.1">
        <property type="protein sequence ID" value="ENSMODP00000051498.1"/>
        <property type="gene ID" value="ENSMODG00000009476.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100026889"/>
    <dbReference type="CTD" id="57698"/>
    <dbReference type="GeneTree" id="ENSGT00510000048167"/>
    <dbReference type="OrthoDB" id="6111338at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009476">
        <property type="expression patterns" value="Expressed in spinal cord and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024849">
        <property type="entry name" value="Shootin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606:SF3">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="342"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="137"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="456" mass="52479" checksum="F5012B3C502DB079" modified="2019-12-11" version="1">MNSSDEEKQLQLITSLKEQAIGEYEDLKAENKKTKEKCDKIKQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSATETEGTSGTCDSVQCQQQIKDLRDQILSVQEEKKTLAIELENLRSKLVEVLEEVNKVKQEKAVLNSEVLEQRKVLEKCNRVSILAVEEYEEMQVNLELEKDLRKKAETFAQEMFIEQNKLKRQSHLLLQSSAPDQQLLKALEENAKLTQILEEERIQHQQKVKELEEQLDNETLHKEIHNLKQQLELLEEDKKELELKCQNSEERAKNLKHSVDELQKRVHQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSSSGAKKEKAVQPETVEEVTDLKRQAVEEMMDRIKKGVHLRPVNQATRPKAKPESSKGSESAVNELKGILTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV47</accession>
    <name>A0A5F8GV47_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Zinc finger protein 850-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV47"/>
    <dbReference type="Ensembl" id="ENSMODT00000052452.1">
        <property type="protein sequence ID" value="ENSMODP00000051372.1"/>
        <property type="gene ID" value="ENSMODG00000050222.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234576"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000050222">
        <property type="expression patterns" value="Expressed in uterus and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004935">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002519">
        <property type="entry name" value="zinc finger protein 252-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000801">
        <property type="entry name" value="zinc finger protein 461 isoform X2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001402">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002235">
        <property type="entry name" value="Zinc finger protein 549"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001396">
        <property type="entry name" value="Zinc finger protein 585A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000292">
        <property type="entry name" value="zinc finger protein 619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000113">
        <property type="entry name" value="zinc finger protein 699 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000057">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="32"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="17">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="895"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="923"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="951"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="979"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1007"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1035"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1063"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1090"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1124" mass="130099" checksum="0E179D50E5C50FB2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV50</accession>
    <name>A0A5F8GV50_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">MAX gene-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MGA</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000083364.1">
        <property type="protein sequence ID" value="ENSMODP00000051503.1"/>
        <property type="gene ID" value="ENSMODG00000000052.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156269"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000052">
        <property type="expression patterns" value="Expressed in forelimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18911">
        <property type="entry name" value="bHLHzip_MGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20195">
        <property type="entry name" value="T-box_MGA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000009">
        <property type="entry name" value="MAX gene-associated protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000040">
        <property type="entry name" value="MAX gene-associated protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037935">
        <property type="entry name" value="MAX_gene-associated_bHLHzip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032060">
        <property type="entry name" value="MGA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF32">
        <property type="entry name" value="MAX GENE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16059">
        <property type="entry name" value="MGA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="T-box" evidence="16">
        <location>
            <begin position="79"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="17">
        <location>
            <begin position="2396"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="259"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="591"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="874"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1109"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1373"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1720"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1786"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1918"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1987"/>
            <end position="2054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2110"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2258"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2503"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2639"/>
            <end position="2661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2912"/>
            <end position="2954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="900"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="939"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1113"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1394"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1720"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1793"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1918"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2012"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2024"/>
            <end position="2054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2110"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2128"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2161"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2181"/>
            <end position="2195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="2274"/>
            <end position="2294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2298"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2640"/>
            <end position="2649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2912"/>
            <end position="2937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="3039" mass="332458" checksum="772735FC7478FAA4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV51</accession>
    <name>A0A5F8GV51_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Kinesin family member 13A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KIF13A</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000067236.1">
        <property type="protein sequence ID" value="ENSMODP00000051091.1"/>
        <property type="gene ID" value="ENSMODG00000011220.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157508"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011220">
        <property type="expression patterns" value="Expressed in heart and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22729">
        <property type="entry name" value="FHA_KIF13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000015">
        <property type="entry name" value="Kinesin family member 13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000002">
        <property type="entry name" value="Kinesin family member 13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000010">
        <property type="entry name" value="Kinesin family member 13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="5"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="14">
        <location>
            <begin position="1861"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1616"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1746"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1912"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1623"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1913"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1973" mass="220528" checksum="6C2AF666604F329E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV55</accession>
    <name>A0A5F8GV55_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NACHT and WD repeat domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NWD2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV55"/>
    <dbReference type="Ensembl" id="ENSMODT00000087896.1">
        <property type="protein sequence ID" value="ENSMODP00000051425.1"/>
        <property type="gene ID" value="ENSMODG00000040392.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153648"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000040392">
        <property type="expression patterns" value="Expressed in heart and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF39">
        <property type="entry name" value="NACHT AND WD REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="129" mass="14397" checksum="9EB7DD889DA42653" modified="2019-12-11" version="1">MWPAGAGSKLPCARDSALRRAAFSGNLTALPSHLVPAGRSVRVFISANPEDTGAERQALRENVYPKLREFCRENYGLEFQVIDLYWGLDEDEWDSPELQKTRMKLLEDCLKTSAGPCFVVLHALTPSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV56</accession>
    <name>A0A5F8GV56_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MCF.2 cell line derived transforming sequence-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MCF2L2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV56"/>
    <dbReference type="Ensembl" id="ENSMODT00000072210.1">
        <property type="protein sequence ID" value="ENSMODP00000051377.1"/>
        <property type="gene ID" value="ENSMODG00000021286.4"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100016160"/>
    <dbReference type="GeneTree" id="ENSGT00940000161734"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021286">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000078">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF201">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MCF2L2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23289">
        <property type="entry name" value="Spectrin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="7">
        <location>
            <begin position="93"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="627"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="819"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="964"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="969"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="993"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1040"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1123" mass="127663" checksum="56B44648B27247E6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV57</accession>
    <name>A0A5F8GV57_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Desmoglein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DSG4</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Cell membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV57"/>
    <dbReference type="Ensembl" id="ENSMODT00000076177.1">
        <property type="protein sequence ID" value="ENSMODP00000051254.1"/>
        <property type="gene ID" value="ENSMODG00000038707.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234624"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000038707">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000011">
        <property type="entry name" value="Cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000031">
        <property type="entry name" value="Cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000068">
        <property type="entry name" value="Desmoglein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000083">
        <property type="entry name" value="Desmoglein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000003">
        <property type="entry name" value="Desmoglein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000074">
        <property type="entry name" value="Desmoglein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009122">
        <property type="entry name" value="Desmosomal_cadherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF10">
        <property type="entry name" value="DESMOGLEIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01818">
        <property type="entry name" value="DESMOCADHERN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01819">
        <property type="entry name" value="DESMOGLEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 15 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023909926" evidence="20">
        <location>
            <begin position="24"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="76"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="158"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="269"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="385"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1006"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1025" mass="112235" checksum="E65C15838EE8BA52" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV58</accession>
    <name>A0A5F8GV58_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger FYVE-type containing 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ZFYVE27</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV58"/>
    <dbReference type="Ensembl" id="ENSMODT00000062307.1">
        <property type="protein sequence ID" value="ENSMODP00000051513.1"/>
        <property type="gene ID" value="ENSMODG00000003907.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013298"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003907">
        <property type="expression patterns" value="Expressed in spinal cord and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071787">
        <property type="term" value="P:endoplasmic reticulum tubular network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042405">
        <property type="entry name" value="Protrudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14543">
        <property type="entry name" value="PROTRUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14543:SF1">
        <property type="entry name" value="PROTRUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0967">Endosome</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="349" mass="39658" checksum="25536CDDDF2C29DC" modified="2019-12-11" version="1">MPEAQPDSPPAPPKPPVLDLFNLVLFYKRLVVYLEPLKDAFDGILYLLRWQTPVCSLLTCLGLNFLFLTLNEGAWYSVGALLISVPALLGYLQEVFRTRLSETELIRRKYHSVRQEDLQKVRLSRPEAVAEVKTFLIQLENFLNRLCNSCEAVYRVLYWENPVVSSQFYGLLLGSIFVLYLLPLCWILALLNSTLFLGNVEFYRVVAECRATLQQRMNPQLPGNTEDCLESDSGGRGVLLDCSSTPTPTEDLTPGSVEEAEEAEPDEEFKDAIEEDEEGSACSVEDDLALHDNGFMSKNEVIRSKVSRLTEKLRKRYPTNNFGALYLISLRMYVIMGSSWERKAFLEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6R1</accession>
    <name>A0A5F8H6R1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KRBA1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_056655837.1">
        <property type="nucleotide sequence ID" value="XM_056799859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6R1"/>
    <dbReference type="Ensembl" id="ENSMODT00000058775.1">
        <property type="protein sequence ID" value="ENSMODP00000055477.1"/>
        <property type="gene ID" value="ENSMODG00000027603.2"/>
    </dbReference>
    <dbReference type="GeneID" id="103106166"/>
    <dbReference type="CTD" id="84626"/>
    <dbReference type="GeneTree" id="ENSGT00390000006211"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000027603">
        <property type="expression patterns" value="Expressed in cerebellum and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040095">
        <property type="entry name" value="KRBA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029317">
        <property type="entry name" value="KRBA1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22740">
        <property type="entry name" value="PROTEIN KRBA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22740:SF3">
        <property type="entry name" value="PROTEIN KRBA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15287">
        <property type="entry name" value="KRBA1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01258">
        <property type="entry name" value="KRBA1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="2">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1159" mass="124109" checksum="203B91EA4DF1D2E8" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6R2</accession>
    <name>A0A5F8H6R2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Zinc finger protein OZF-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC103105060</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056656940.1">
        <property type="nucleotide sequence ID" value="XM_056800962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6R2"/>
    <dbReference type="Ensembl" id="ENSMODT00000060198.1">
        <property type="protein sequence ID" value="ENSMODP00000055244.1"/>
        <property type="gene ID" value="ENSMODG00000046545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103105060"/>
    <dbReference type="GeneTree" id="ENSGT00940000153582"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000046545">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003102">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001336">
        <property type="entry name" value="Zinc finger protein 334"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001016">
        <property type="entry name" value="zinc finger protein 850-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000057">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF246">
        <property type="entry name" value="GENE, 19965-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="17">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="497" mass="57835" checksum="AC581EF7A052146A" modified="2019-12-11" version="1">MTPGRGSPPSQEVVTFQDVAVNFTREEWRLLSPPQKELYREVMLENARNLLSVEEDIRLEIKAIPTEESLSVKERDQQRFMRGGPYNCVVSQNSSLIEYQRMHTEQNSSECKQCGKTFMHKASLAGHQRIHSGEKSYECKHCGKAFRGNSELALHQRIHPGEKPCEYKQCRRTFSGSASLAQHQRIHTGEKPFECKQCGKTFRQISSLVRHHRIHSAEKFYEGKQCGKTFSRSSYLADHQKIHTGEKPFECKECKRTFSQSSKLAQHQRIHTVEKSNECKQCGKTFSGSYYLADHQRIHTGEKPYECKQCGKTFRQASNLVVHLRIHTGEKPFQCKQCGKTFRENSKLTLHWRIHTGEKPFECNRCGKTFRQSSSLARHQRIHTGEKPFECKQCGKTFRQSSSLARHQRIHSGEKPYECKQCRKKFSRSCYLADHQRIHTGEKPYECRQCGKTFWESSCLARHQRIHTGEKPYECKQCGKTFRDNSCLSRHQKIHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6R4</accession>
    <name>A0A5F8H6R4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein naked cuticle homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NKD1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cell autonomous antagonist of the canonical Wnt signaling pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with DVL1, DVL2, DVL3 and PPP2R3A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the NKD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6R4"/>
    <dbReference type="Ensembl" id="ENSMODT00000075311.1">
        <property type="protein sequence ID" value="ENSMODP00000055628.1"/>
        <property type="gene ID" value="ENSMODG00000013068.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000033589"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013068">
        <property type="expression patterns" value="Expressed in lung and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000166">
        <property type="entry name" value="Naked cuticle homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040140">
        <property type="entry name" value="Nkd-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22611">
        <property type="entry name" value="PROTEIN NAKED CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22611:SF2">
        <property type="entry name" value="PROTEIN NAKED CUTICLE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="459" mass="51827" checksum="98067F53A0F675FE" modified="2019-12-11" version="1">EARPTAAVCKRRESPEGDSFAVNASWARKGIEDWIGKQRYPSSGPGSRQPRVVGGFSGGTRDPAGEVYRETISEEHFRLEVSLPPEKTDGPGSGDEKKAEKDSESCPSSKKQLKFEELQCDVSVEEDNRQEWTFTLYDFDNNGKVTREDITSLLHTIYEVVDSSVNHSPTSSKTLRVKLTVAPDGSQKRKSILLNHADLPSLRRRTESKANEELRSLEKKQRAPLRYHGDAHLEQSGRYRHCVDENIERRNHYLDLAGIENYTSKFGPGSPSQKPELPTRVPIQTRSRSHEPETIHVHHRKSQGAEPGPFHFMDIPYAKIAEVQQRLRAGQDLSKHFVKSPKAQSKNVGSAHLGRGARSKSILGPAIPLASPTTRPVLTPPYLLGPAPPMHKKHKQRAKESQQMCKSLQPPGSTVVEKEHVRDLPALVLYEGQVGQMVQRHEHHHHHEHHHHYHHFYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6R5</accession>
    <name>A0A5F8H6R5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Zinc finger protein 420-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6R5"/>
    <dbReference type="Ensembl" id="ENSMODT00000069166.1">
        <property type="protein sequence ID" value="ENSMODP00000055482.1"/>
        <property type="gene ID" value="ENSMODG00000051415.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162725"/>
    <dbReference type="OMA" id="EQRFNFK"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000051415">
        <property type="expression patterns" value="Expressed in uterus and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002079">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002573">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002519">
        <property type="entry name" value="zinc finger protein 252-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000801">
        <property type="entry name" value="zinc finger protein 461 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002004">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000271">
        <property type="entry name" value="Zinc finger protein 662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000113">
        <property type="entry name" value="zinc finger protein 699 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000028">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000592">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000057">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF425">
        <property type="entry name" value="ZINC FINGER PROTEIN 621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="17">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="724" mass="83088" checksum="215DE5D046B9F207" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6R8</accession>
    <name>A0A5F8H6R8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanidinoacetate N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GAMT</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6R8"/>
    <dbReference type="FunCoup" id="A0A5F8H6R8">
        <property type="interactions" value="1148"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055633"/>
    <dbReference type="Ensembl" id="ENSMODT00000065619.1">
        <property type="protein sequence ID" value="ENSMODP00000055633.1"/>
        <property type="gene ID" value="ENSMODG00000043396.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018061"/>
    <dbReference type="InParanoid" id="A0A5F8H6R8"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000043396">
        <property type="expression patterns" value="Expressed in placenta and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030731">
        <property type="term" value="F:guanidinoacetate N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006601">
        <property type="term" value="P:creatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040014">
        <property type="term" value="P:regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RMT2" evidence="6">
        <location>
            <begin position="14"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="298" mass="33234" checksum="1FBC428E5E77D3BA" modified="2019-12-11" version="1">MSAEAAPAPIFQPGEDCRPSWQEAPAGYDGPDTHLQILGKPVMERWETPYMHSLAAVASSRGGRVLEVGFGMAIAASKVQEANIQEHWIIECNDGVFQRLQEWAQRQPHKVVPLKGLWEEVAPNLPDGHFDGILYDTYPLSAETWHTHQFNFIKAHAFRLLKPGGVLTYCNLTSWGELLKTKYTDIKKMFEVSRELDPTACSTTAGTFMLPPSLIISLPFLHTLVFMWISRARYEKEHGPGRQTRTLVIGSVTGLGMITCLWPWVSPSMKEGVGSDIRALRSDDPCPKLACSVSSWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6S3</accession>
    <name>A0A5F8H6S3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6S3"/>
    <dbReference type="Ensembl" id="ENSMODT00000072632.1">
        <property type="protein sequence ID" value="ENSMODP00000054931.1"/>
        <property type="gene ID" value="ENSMODG00000014545.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164663"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014545">
        <property type="expression patterns" value="Expressed in blood and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04981">
        <property type="entry name" value="IgV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001934">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023896452" description="Ig-like domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="34"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="158" mass="18038" checksum="CEB2374FF0115BEC" modified="2019-12-11" version="1">MGFGLNGIFILMILQGVHCDIQLVESGGDVRQPGGSLKLSCKASGFTFSSYYMHWIRQAPGKGLEWLSRIDTAGSSTRYADSVKGRFTISRDNGNSLLHLQMNSLKAEDTATYYCARDTVRERSERADKNLLFRGFWWRMTERELQDSEHKEPSYNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6S6</accession>
    <name>A0A5F8H6S6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RC3H2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6S6"/>
    <dbReference type="Ensembl" id="ENSMODT00000085574.1">
        <property type="protein sequence ID" value="ENSMODP00000055643.1"/>
        <property type="gene ID" value="ENSMODG00000019725.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157685"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019725">
        <property type="expression patterns" value="Expressed in heart and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16782">
        <property type="entry name" value="mRING-HC-C3HC3D_Roquin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1790:FF:000001">
        <property type="entry name" value="roquin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000004">
        <property type="entry name" value="roquin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000047">
        <property type="entry name" value="Roquin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041523">
        <property type="entry name" value="ROQ_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048575">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052249">
        <property type="entry name" value="Roquin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139">
        <property type="entry name" value="RING FINGER AND CCCH-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139:SF2">
        <property type="entry name" value="ROQUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18386">
        <property type="entry name" value="ROQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21206">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="526"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="644"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116127" checksum="617247241AC3994B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6T0</accession>
    <name>A0A5F8H6T0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Basic leucine zipper and W2 domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BZW1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BZW family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6T0"/>
    <dbReference type="FunCoup" id="A0A5F8H6T0">
        <property type="interactions" value="2264"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000085496.1">
        <property type="protein sequence ID" value="ENSMODP00000055264.1"/>
        <property type="gene ID" value="ENSMODG00000015000.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012561"/>
    <dbReference type="InParanoid" id="A0A5F8H6T0"/>
    <dbReference type="OMA" id="TEFCLFR"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015000">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11560">
        <property type="entry name" value="W2_eIF5C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000006">
        <property type="entry name" value="Basic leucine zipper and W2 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043510">
        <property type="entry name" value="W2_5MP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF0">
        <property type="entry name" value="EIF5-MIMIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="278"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="577" mass="65764" checksum="49C1C39590D3B49D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6T1</accession>
    <name>A0A5F8H6T1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Integrin subunit alpha 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ITGA9</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6T1"/>
    <dbReference type="Ensembl" id="ENSMODT00000057868.1">
        <property type="protein sequence ID" value="ENSMODP00000054936.1"/>
        <property type="gene ID" value="ENSMODG00000013303.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156503"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013303">
        <property type="expression patterns" value="Expressed in hindlimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1460:FF:000007">
        <property type="entry name" value="Integrin subunit alpha 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000006">
        <property type="entry name" value="Integrin, alpha 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF69">
        <property type="entry name" value="INTEGRIN ALPHA-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0401">Integrin</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="38"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="293"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="412"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="17">
        <location>
            <begin position="460"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="628" mass="68592" checksum="0A8EB01587422309" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6T7</accession>
    <name>A0A5F8H6T7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6T7"/>
    <dbReference type="Ensembl" id="ENSMODT00000059638.1">
        <property type="protein sequence ID" value="ENSMODP00000055497.1"/>
        <property type="gene ID" value="ENSMODG00000014313.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154203"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014313">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05584">
        <property type="entry name" value="STKc_p70S6K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001128">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000092">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016238">
        <property type="entry name" value="Ribosomal_S6_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000605">
        <property type="entry name" value="Ribsml_S6_kin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="89"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="328"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="500" mass="56054" checksum="2A9CB05CC75780BB" modified="2019-12-11" version="1">MRRRRRRDGFYPAPDFRDGEAEAMAGVFDIDLDQPEDAGSEDELEEGGQLSESMDHGGVAECGMEHCEKFEISETSVNKGPEKIRPECFELLRVLGKGGYGKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASAATTQTPVDYPMETSGIEQMDVTVSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H730</accession>
    <name>A0A5F8H730_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="23">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">PLCE1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="23"/>
    <dbReference type="Ensembl" id="ENSMODT00000053741.1">
        <property type="protein sequence ID" value="ENSMODP00000055031.1"/>
        <property type="gene ID" value="ENSMODG00000005750.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157356"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005750">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16203">
        <property type="entry name" value="EFh_PI-PLCepsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08596">
        <property type="entry name" value="PI-PLCc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17229">
        <property type="entry name" value="RA1_PLC-epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01780">
        <property type="entry name" value="RA2_PLC-epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000092">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000085">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000086">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000118">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000090">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046973">
        <property type="entry name" value="PLC-epsilon1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028398">
        <property type="entry name" value="PLC-epsilon1_RA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046974">
        <property type="entry name" value="PLC_epsilon1_EF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF6">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 22" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="13 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 23" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="17 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="19" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Ras-GEF" evidence="27">
        <location>
            <begin position="529"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="26">
        <location>
            <begin position="1686"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="25">
        <location>
            <begin position="1782"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="28">
        <location>
            <begin position="2069"/>
            <end position="2168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1053"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1105"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1490"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1614"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="2193"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1107"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1493"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="1511"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="2193"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="2221"/>
            <end position="2230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00059831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2230" mass="250355" checksum="7F5522AA7CD7659F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H732</accession>
    <name>A0A5F8H732_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PDE6C</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H732"/>
    <dbReference type="Ensembl" id="ENSMODT00000064473.1">
        <property type="protein sequence ID" value="ENSMODP00000055359.1"/>
        <property type="gene ID" value="ENSMODG00000005884.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157825"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005884">
        <property type="expression patterns" value="Expressed in placenta and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000005">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000010">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0140">cGMP</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="469"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="785"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="545"/>
            <end position="549"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="845" mass="98349" checksum="C6906C4535F49B30" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H733</accession>
    <name>A0A5F8H733_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain containing 92</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CCDC92</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007489996.1">
        <property type="nucleotide sequence ID" value="XM_007489934.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H733"/>
    <dbReference type="Ensembl" id="ENSMODT00000079259.1">
        <property type="protein sequence ID" value="ENSMODP00000055795.1"/>
        <property type="gene ID" value="ENSMODG00000012594.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100024246"/>
    <dbReference type="CTD" id="80212"/>
    <dbReference type="GeneTree" id="ENSGT00430000031027"/>
    <dbReference type="OrthoDB" id="2155209at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012594">
        <property type="expression patterns" value="Expressed in spermatocyte and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040370">
        <property type="entry name" value="CCDC74A/CCDC74B/CCDC92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039496">
        <property type="entry name" value="CCDC92/74_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14916">
        <property type="entry name" value="CCDC92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC92/74 N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="345" mass="37917" checksum="2AA4DC8273E35EC1" modified="2019-12-11" version="1">MEKPGSWKNGHSGSVCKGHLDVSMAASNLENQLHSAQKNLLFLQREHANTLKGLHAEIRRLQQHCTDLTYELTLKSSEQAGDGTSRSNELKRKCEDLEAELKAKEAEKQELLQELEQKNALIAVLETTVKEREKKYLEELKLKSHKLSVLSGELEQRAGTIAYLTSQLHATKKKLLLSPADAASAPTSGSAAGASAAAAAAGYKPAPPKEKLPETPRRRMKKSLSAPLNPDFEEVYRLGSDRKLLFREPVDAMPDPTPFLLAREAAEVHLIKERPLVIPPIASERTSGDPHSPARDKAHKAHVGVAHRIHHVPQPQAQPEVETLAVDQVNGSKVVRKHSGTDRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H736</accession>
    <name>A0A5F8H736_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H736"/>
    <dbReference type="Ensembl" id="ENSMODT00000077867.1">
        <property type="protein sequence ID" value="ENSMODP00000055036.1"/>
        <property type="gene ID" value="ENSMODG00000023262.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182886"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023262">
        <property type="expression patterns" value="Expressed in ovary and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF59">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="231" mass="26613" checksum="07D5208D4C20F642" modified="2019-12-11" version="1">MVFLIEYAGSLFIYLLFYLRMPFVYGLEKKLMSRRLPVVNLACICHSSHYIKRLIETIFVHRFSHGTMPLKSIVKNCFFYWGFAAWLAYYINHPLYTPPSYGQKQINFSLITFLLCEAGNFSIHVELNNLRGNGPKTRRIPYPTKNPFTWLFFFVSCPNYTYEVGAWISFTIMTQCVPAQARCRSLPVYGNSHNLGHLQGMALIGAAHDSRGSGSQTFQLLIHLKCCRPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H737</accession>
    <name>A0A5F8H737_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD repeat and FYVE domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">WDFY1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056663439.1">
        <property type="nucleotide sequence ID" value="XM_056807461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H737"/>
    <dbReference type="FunCoup" id="A0A5F8H737">
        <property type="interactions" value="3833"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055607"/>
    <dbReference type="Ensembl" id="ENSMODT00000076844.1">
        <property type="protein sequence ID" value="ENSMODP00000055607.1"/>
        <property type="gene ID" value="ENSMODG00000021199.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022452"/>
    <dbReference type="CTD" id="57590"/>
    <dbReference type="GeneTree" id="ENSGT00940000157731"/>
    <dbReference type="InParanoid" id="A0A5F8H737"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021199">
        <property type="expression patterns" value="Expressed in endometrium and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034141">
        <property type="term" value="P:positive regulation of toll-like receptor 3 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034145">
        <property type="term" value="P:positive regulation of toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000433">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF2">
        <property type="entry name" value="WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="311"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="440" mass="49690" checksum="776207CC4C6A306A" modified="2019-12-11" version="1">MHRDSPTLSALEAWVHWHEKSLHLETSSAALDGCVVFCAPTRPKHSTVPCCIAISAVEPSFWFLPPVTSKQSSYAGTIRVWLKRDSGQYWPSIYHTMASPCSSMAYHHDSRRIFVGQDNGAIMEFHISEDFNKMNFVKTYPAHQSRVSAVVFCLGAEWVISTGHDKCVSWMCTRSGNMLGKHFFTSWASCLQFDLDTQHAFVGDYSGQITLLKLEQNTCSIITTLKGHEGSIASLWWDPIQRLLFSGASDNSIIMWDIGGRKGRMLLLQGHHDRVQSLCYLSLTRQLVSCSSDGGIAVWNMDVRREEAPQWLESDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGQAVCGKCSTRRSTYPVMGFEFQVRMCDSCYDSVKDEDRTSLATFHEGKHNISHMSMDVARGLMVTCGTDRVVKIWDMTPVVGCSLATGFSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H738</accession>
    <name>A0A5F8H738_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C2 domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">C2CD5</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H738"/>
    <dbReference type="Ensembl" id="ENSMODT00000088238.1">
        <property type="protein sequence ID" value="ENSMODP00000055364.1"/>
        <property type="gene ID" value="ENSMODG00000017718.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000212"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017718">
        <property type="expression patterns" value="Expressed in cerebellum and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08688">
        <property type="entry name" value="C2_KIAA0528-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000020">
        <property type="entry name" value="C2 calcium dependent domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037785">
        <property type="entry name" value="C2_C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038983">
        <property type="entry name" value="C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057815">
        <property type="entry name" value="C2CD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056430">
        <property type="entry name" value="C2CD5_YbjQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056431">
        <property type="entry name" value="C2CD5_YbjQ-rel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412:SF2">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23025">
        <property type="entry name" value="YbjQ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23028">
        <property type="entry name" value="YbjQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23128">
        <property type="entry name" value="YbjQ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="265"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="985" mass="108658" checksum="1B39E5AC2735AA73" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H740</accession>
    <name>A0A5F8H740_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000071845.1">
        <property type="protein sequence ID" value="ENSMODP00000055041.1"/>
        <property type="gene ID" value="ENSMODG00000027970.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000027970">
        <property type="expression patterns" value="Expressed in spermatid and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="108"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="201"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="288"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="377"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="464"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="553"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="640"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="729"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="814"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="905"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="992"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1081"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1168"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1257"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1344"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1433"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1520"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1609"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1692"/>
            <end position="1780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1803" mass="196149" checksum="571B6A74E3EE42F6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H741</accession>
    <name>A0A5F8H741_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ring finger protein 167</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RNF167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H741"/>
    <dbReference type="Ensembl" id="ENSMODT00000070232.1">
        <property type="protein sequence ID" value="ENSMODP00000055763.1"/>
        <property type="gene ID" value="ENSMODG00000005330.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159547"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005330">
        <property type="expression patterns" value="Expressed in lung and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02123">
        <property type="entry name" value="PA_C_RZF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044744">
        <property type="entry name" value="ZNRF4/RNF13/RNF167_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702:SF1">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="143" mass="15954" checksum="499517636815D422" modified="2019-12-11" version="1">MRPEAFPFPVLMATLLWGITPTWGLIRAGFLVEAHPANACSPINPPPLAPANGSVFIALLRRFDCNFDLKVLNAQRAGYRAAVVYNVNSNELLNMVWNSEEIQQQIWIPSVFVGETSSEYLRSLFVYDKGYDVSSLSSPSIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H742</accession>
    <name>A0A5F8H742_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC100617898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H742"/>
    <dbReference type="Ensembl" id="ENSMODT00000068309.1">
        <property type="protein sequence ID" value="ENSMODP00000055612.1"/>
        <property type="gene ID" value="ENSMODG00000046378.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000074417.1">
        <property type="protein sequence ID" value="ENSMODP00000046615.1"/>
        <property type="gene ID" value="ENSMODG00000046378.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153934"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000046378">
        <property type="expression patterns" value="Expressed in blood and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001181">
        <property type="entry name" value="Immunoglobulin lambda variable 9-49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044621521" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="125" mass="13628" checksum="9E76A1FB907EDF2B" modified="2019-12-11" version="1">MAWPLVCLSLLTFCSGSLSQPVVIQSPSVSASLGSSARLTCTLSSQHSSYYINWYQQSPGKPPLYLMWVKSDGSIGRGDGIPERFSGSSSGADRFLSINNIQPEDEADYFCGYAYDSGSSYRYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H743</accession>
    <name>A0A5F8H743_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FARS2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H743"/>
    <dbReference type="Ensembl" id="ENSMODT00000075347.1">
        <property type="protein sequence ID" value="ENSMODP00000055805.1"/>
        <property type="gene ID" value="ENSMODG00000009839.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158071"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009839">
        <property type="expression patterns" value="Expressed in hindlimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000041">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="176"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="15">
        <location>
            <begin position="359"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="424" mass="49181" checksum="DECB0741A81A9914" modified="2019-12-11" version="1">MTFWSLTKNVQHNHLKVCSNWVRSIFQRNRSLASQTISTELAAASGPSGSSVEVLGKSYPRDDHSNVPGKILSKVGKNLHQRKYHPLWLVLERVKRHFYQQYVGLYGTPLFSVFDSLSPVVTPWQNFDSLLVPADHPSRKKGDNYYLNRAHMLRSHTSAHQWNLMRAGLKAFLVVGDVYRRDQIDSHHYPVFHQLEAVRLFSKRQLFGDMKDGEPLQLFEHSSRSAHKQETHTMEAVKLVECDLKQTLTKLITHLFGVGLEIRWVDCYFPFTHPSFEMEINFQGEWIEVLGCGIMEQQLVNSAGAQNNIGWAFGLGLERLAMILYNIPDIRLFWSEDERFLKQFYVPDINQDVQFQPLSKYPALVNDISFWLPLQNYSENDFYDLVRAVGGDLVERVDLIDKFEHPNDQQYFSPLSFRSIQNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H744</accession>
    <name>A0A5F8H744_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tripartite motif containing 63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TRIM63</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H744"/>
    <dbReference type="Ensembl" id="ENSMODT00000065413.1">
        <property type="protein sequence ID" value="ENSMODP00000055369.1"/>
        <property type="gene ID" value="ENSMODG00000014098.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156529"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014098">
        <property type="expression patterns" value="Expressed in heart and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19831">
        <property type="entry name" value="Bbox2_MuRF1_C-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000014">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase MID2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000022">
        <property type="entry name" value="Tripartite motif containing 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000140">
        <property type="entry name" value="Tripartite motif containing 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="142"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="COS" evidence="12">
        <location>
            <begin position="384"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="334"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="483" mass="54627" checksum="64294C56DFB33FD1" modified="2019-12-11" version="1">MRKLTLLQREEAAPPLAAFSQRESAHSNQSLDKKIYLSVLKVDSHRKIDKSKLPRYLLPVSKLQKVTSSPIVFPNIQVSFTMTQRKFSLSLKEQRPGSWDLQPVCSESAGEARSCSSGGMDYKSGLIQDSNPMENLEKQLICPICLEMFTKPVVILPCQHNLCRKCANDVFQAANPYWSNRGGSISGGRFRCPSCRHEVIMDRHGVYGLQRNLLVENIIDIYKQECSSRPLQKGNHPMCKEHEDEKINIYCLTCEVPTCSMCKVFGAHKACEVAPLQNVFQGQKTELSNCISMLVAGNDRVQTIITQLEDSCRVTKENSHQVKEELSEKFDVLYAILDEKKSELLQRITREQEEKISFIEALIQQYREQLEKATKLVETAIQSMDEPGGAAFLMNAKPLIKAIVEASKGCHLGKTEQGFENMDYFTLDLEHLADTLRAIDFGSDEEEEEFIEAEGDEDEQEEEDPSGGEDGRSTGRRQEEELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H747</accession>
    <name>A0A5F8H747_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ETS variant transcription factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ETV4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H747"/>
    <dbReference type="Ensembl" id="ENSMODT00000063147.1">
        <property type="protein sequence ID" value="ENSMODP00000055617.1"/>
        <property type="gene ID" value="ENSMODG00000015187.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158142"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015187">
        <property type="expression patterns" value="Expressed in hindlimb bud and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006715">
        <property type="entry name" value="ETS_PEA3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF181">
        <property type="entry name" value="ETS TRANSLOCATION VARIANT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04621">
        <property type="entry name" value="ETS_PEA3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="335"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="444" mass="49203" checksum="542A09E74941BF55" modified="2019-12-11" version="1">MERRMKGGYVDQQVPYTFSSKSPGNGSLSRALMVTLGKLMDPGSLPPPESEDLFQDLSQFQETWLTEAQVPDSDEQFVPDFHSENLAFHSPTTKIKKEPQSPRADPTLSCSRKPPLSYHHGEQCLYTSAYDTPRQVAIKSPTHSAPGQSPLQHFPRAERSFLRPPGAAPSNPSHGFMMEPSSIFQQPPEICHSFPSSQGGGREPPSASYQPQLPEPCLPYPQQSFKREYHDPLYEQAGGGGGSARYPGAGVVIKQEQTDFAYDSDVPGCQSMYLHAEGFPGPTPGEGTMGYGFEKSLRPFPEDVCVVPEKFEGDIKQEGLGTFREGPPYQRRGSLQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVAGERYVYKFVCEPEALFSLAFPDNQRPTLKSEFDRPVSEEDTVPLSHLDDSPAYLPELGGPVQPYGPKGGYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H748</accession>
    <name>A0A5F8H748_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000056993.1">
        <property type="protein sequence ID" value="ENSMODP00000055810.1"/>
        <property type="gene ID" value="ENSMODG00000006171.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162673"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006171">
        <property type="expression patterns" value="Expressed in liver and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000436">
        <property type="entry name" value="ATP binding cassette subfamily A member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF274">
        <property type="entry name" value="ABC-TYPE ORGANIC ANION TRANSPORTER ABCA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="910"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="955"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="382"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1109"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1450" mass="164682" checksum="68C1DF0A5DD937A0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H750</accession>
    <name>A0A5F8H750_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">POU class 2 homeobox associating factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">POU2AF3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003341319.1">
        <property type="nucleotide sequence ID" value="XM_003341271.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H750"/>
    <dbReference type="Ensembl" id="ENSMODT00000086751.1">
        <property type="protein sequence ID" value="ENSMODP00000055051.1"/>
        <property type="gene ID" value="ENSMODG00000029830.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100620017"/>
    <dbReference type="KEGG" id="mdo:100620017"/>
    <dbReference type="CTD" id="120376"/>
    <dbReference type="GeneTree" id="ENSGT00420000030454"/>
    <dbReference type="OrthoDB" id="9942157at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000029830">
        <property type="expression patterns" value="Expressed in lung and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070974">
        <property type="term" value="F:POU domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047571">
        <property type="entry name" value="OCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043265">
        <property type="entry name" value="OCAT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36689">
        <property type="entry name" value="COLORECTAL CANCER-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36689:SF1">
        <property type="entry name" value="POU CLASS 2 HOMEOBOX ASSOCIATING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52003">
        <property type="entry name" value="OCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="258" mass="28706" checksum="CEAE5F6E61C678C2" modified="2019-12-11" version="1">MNFPSEKPKVYQGVRVKITVKELLQQRRAHQAASGGTLSRSSSVQFSEAVSPSSAAPHFEPEPISSAPNYFQPQQFSSCVSCEENSNCLDQIFESYLPPETLQDHSLSSTQGVPPCFPDSFQATPFCFNQSLVPGSPSDSSTLSSPLDYSYSPPQQPSLAPVTYSYSSSLDTRNCGYPSEEYSYHHFHSHLQYSRCTSSSSSSICYCTSCETEHLDTIKVSEYFSYPDTDYIDYSHSLPTAVADDFYRREADCDICYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H756</accession>
    <name>A0A5F8H756_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ASL</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues. Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24021"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:24022"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer. Forms tissue-specific complexes with ASS1, SLC7A1, HSP90AA1 and nitric oxide synthase NOS1, NOS2 or NOS3; the complex maintenance is independent of ASL catalytic function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H756"/>
    <dbReference type="Ensembl" id="ENSMODT00000077757.1">
        <property type="protein sequence ID" value="ENSMODP00000055622.1"/>
        <property type="gene ID" value="ENSMODG00000027474.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183122"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000027474">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000015">
        <property type="entry name" value="argininosuccinate lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000014">
        <property type="entry name" value="Os03g0824900 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0835">Urea cycle</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="14">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="15">
        <location>
            <begin position="338"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="434" mass="48630" checksum="6279578555E1F4E7" modified="2019-12-11" version="1">SGKLWGGRFVGSIDPIMEKFNSSISYDQRMWEADIQGSKAYSKGLENAGLLTKAELEKILHGLDKVAEEWDKGTFALNPHDEDIHTANERRLKELIGEAAGKLHTGRSRNDQVVTDLRLWMRKSCSTLSAHLKMLITTMVERAEAEKDVLFPGYTHLQRAQPIRWSHWILSGAIAGNPLGVDRKLLQKELNFSAITLNSMDATSERDFVAEFLFWASLCMTHLSKMAEDLIIYGTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMNSVLQVATGMISTMKINKACMENALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKQLSLSQLPVKELQSISPLFSGDVCQVWNYANSVEQYKALGGTAKSSVEWQIQQLRELLQRHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H757</accession>
    <name>A0A5F8H757_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DIMT1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13 14">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_056680849.1">
        <property type="nucleotide sequence ID" value="XM_056824871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H757"/>
    <dbReference type="Ensembl" id="ENSMODT00000088612.1">
        <property type="protein sequence ID" value="ENSMODP00000055783.1"/>
        <property type="gene ID" value="ENSMODG00000025599.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100018334"/>
    <dbReference type="CTD" id="27292"/>
    <dbReference type="GeneTree" id="ENSGT00950000183142"/>
    <dbReference type="OMA" id="GMFQKEV"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025599">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.480:FF:000001">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 14" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="15">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="285" mass="32151" checksum="0D7C6D11A1FBCC57" modified="2019-12-11" version="1">MFNTGLGQHILKNPLIVNSIIDKAALRPTDVVLEVGPGTGNMTVKLLEKAKKVVACELDPRLVAELHKRVQGTPQASKLQVMVGDVLKTDLPFFDACVANLPYQISSPFVFKLLLHRPFFRCAILMFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPPPINFQEWDGLVRITFVRKNKTLSAAFKSSAVQQLLEKNYRIHCSVHNIAIPEDFSIADKIQKILMDTGFSDKRARSMDIDDFIRLLHGFNAEGIHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H758</accession>
    <name>A0A5F8H758_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100024333</name>
        <name evidence="17" type="synonym">DDX19B</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_001375627.1">
        <property type="nucleotide sequence ID" value="XM_001375590.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H758"/>
    <dbReference type="Ensembl" id="ENSMODT00000057948.1">
        <property type="protein sequence ID" value="ENSMODP00000055627.1"/>
        <property type="gene ID" value="ENSMODG00000014494.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100024333"/>
    <dbReference type="KEGG" id="mdo:100024333"/>
    <dbReference type="GeneTree" id="ENSGT00940000154417"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014494">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000357">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="181"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="362"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="535" mass="59989" checksum="65715DAF7D36AC27" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F6SFF9</accession>
    <name>F6SFF9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">STE20-related kinase adapter protein alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">STE20-related adapter protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">STRADA</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6SFF9"/>
    <dbReference type="Ensembl" id="ENSMODT00000012500.4">
        <property type="protein sequence ID" value="ENSMODP00000012275.3"/>
        <property type="gene ID" value="ENSMODG00000009817.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158827"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009817">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08227">
        <property type="entry name" value="PK_STRAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000130">
        <property type="entry name" value="STE20-related kinase adapter protein alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000213">
        <property type="entry name" value="STE20-related kinase adapter protein alpha isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF20">
        <property type="entry name" value="STE20-RELATED KINASE ADAPTER PROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="44"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000012275.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="406" mass="45183" checksum="912CB0E7AE75FB55" modified="2019-12-11" version="2">MNFSTPEQPPGDARRKTNESSSESIASSPKQDTMSSFLPEGGCYELLTVIGKGFEELMTVNLARYKPTGEHVTIRRINLEACTNEMVTFLQGELHVSKLFNHPNIVPYRATFVADNELWVVTSFMAYGSAKDLICTQFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISADGKVYLSGLRSSLSMISHGQRQRVVHDFPKYSIKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTTTIPAEELTMNTSRSGANSGLNEGLAASTTRNSNGDSPPHPYHRTFSPHFHHFVEQCLQRSPDFRPSASTLLNHSFFKQIKRRASEALPELLRPVSPITNFEGSQPQDPSGIFGLVSSLDELEMDDWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F6TIB4</accession>
    <name>F6TIB4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6TIB4"/>
    <dbReference type="Ensembl" id="ENSMODT00000040149.3">
        <property type="protein sequence ID" value="ENSMODP00000038549.3"/>
        <property type="gene ID" value="ENSMODG00000039084.1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162079"/>
    <dbReference type="HOGENOM" id="CLU_013137_22_2_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000039084">
        <property type="expression patterns" value="Expressed in liver"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6TIB4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05713">
        <property type="entry name" value="IgV_MOG_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000088">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000208">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF64">
        <property type="entry name" value="BUTYROPHILIN, SUBFAMILY 3, MEMBER A3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="135"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="223"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000038549.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="434" mass="48320" checksum="7BFEDA2C875AA7EC" modified="2019-12-11" version="3">VSMFAALSKMGFLKQFVVLGPTEPIVALLGTDIILPCLLSPLMSAEHMEVRWFRSQFSEAVIVFQKGKEETDEQLVEYTGRTELISEFITEGRLAVKIYNVQISDNGKYQCYFRKGDVYEQASLEVKVAGLGSAPHLRLEGHEDGGVKLACMADGWFPQPQVQWRDNRGGKLSSLSETQAQDEAGFFHMKALIVVQESSVRNVSCSICNKLLSQEKISAIDIPEQFKVLGPTGPIVAILDTDVTLPCRLSPLMNAEHMDIRWLRSQFYEAVFVFQNGREQVGEQLVEYMGRTEFISDFIKEGRVAVKIYNVKMSDNGEYQCIFQEGDAYEKAVFEVKVASLGSAPRFHLEGYEDGGIRLVCSADGWFPQPQVQCRDNRGGKLSSLSETQAQDEAGFFHAKTVIVVQDSSVRNISCSIYNLLLGQGKVSTIDISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>F6TII5</accession>
    <name>F6TII5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcium-activated chloride channel N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC100009776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F6TII5"/>
    <dbReference type="Ensembl" id="ENSMODT00000040140.2">
        <property type="protein sequence ID" value="ENSMODP00000038540.2"/>
        <property type="gene ID" value="ENSMODG00000046721.1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRRD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154682"/>
    <dbReference type="HOGENOM" id="CLU_040707_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000046721">
        <property type="expression patterns" value="Expressed in uterus and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6TII5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023933965" description="Calcium-activated chloride channel N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated chloride channel N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000038540.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="246" mass="27940" checksum="145A0494A814F0E6" modified="2019-12-11" version="2">DIFPFLVPPFLFLPLPPLLPSLFCLNGNGYEDVVIAIDPNVPEDEKLIQQIQDMVTEASTYLYGATEKRFYFKAVSILIPETWQKKNEYEEPKLETYKKADIVIEVPNPPGFDVPRTDQFGQCGDKGERIRLTPAIVLGEKLNEYGPQGKILVHEWAHLRWGVFEEYNEEEPFYQISRQCSDGITGTNKVYACSGGSCSIRNCRTDPKTGKLNKDCMFIPDKVQGEKASIMFMQSIDSVSIWIISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F6ULE0</accession>
    <name>F6ULE0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 5 open reading frame 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">C5orf24</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0461 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6ULE0"/>
    <dbReference type="Ensembl" id="ENSMODT00000018258.4">
        <property type="protein sequence ID" value="ENSMODP00000017928.3"/>
        <property type="gene ID" value="ENSMODG00000014344.4"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100014374"/>
    <dbReference type="eggNOG" id="ENOG502RZTV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014889"/>
    <dbReference type="HOGENOM" id="CLU_090677_0_0_1"/>
    <dbReference type="OMA" id="TAHFDLC"/>
    <dbReference type="OrthoDB" id="10072110at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014344">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040419">
        <property type="entry name" value="DUF5568"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31894">
        <property type="entry name" value="UPF0461 PROTEIN C5ORF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31894:SF0">
        <property type="entry name" value="UPF0461 PROTEIN C5ORF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17724">
        <property type="entry name" value="DUF5568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000017928.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="158" mass="16747" checksum="B8BC5FBFB0E0A4F9" modified="2019-12-11" version="2">MMHPVASGNTAFCGPGKASCLNEDNMRAADQFDLYSSQQSKYSHTVSHKPIACQRQDPLNETHLQATSGRSIETKDELKKKKNLSRSGKRGRPSGTTKSAGYRTSTGRPLGTTKAAGFKTSPGRPLGTTKAAGYKVSPGRPPGKSSKPSGVPVMPNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F6X3L4</accession>
    <name>F6X3L4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Thymopoietin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMPO</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LEM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007503316.1">
        <property type="nucleotide sequence ID" value="XM_007503254.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6X3L4"/>
    <dbReference type="Ensembl" id="ENSMODT00000038205.2">
        <property type="protein sequence ID" value="ENSMODP00000036612.2"/>
        <property type="gene ID" value="ENSMODG00000007723.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100012919"/>
    <dbReference type="CTD" id="7112"/>
    <dbReference type="eggNOG" id="ENOG502QWCI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154098"/>
    <dbReference type="HOGENOM" id="CLU_032534_1_0_1"/>
    <dbReference type="OMA" id="VKPSEYW"/>
    <dbReference type="OrthoDB" id="10072362at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007723">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12940">
        <property type="entry name" value="LEM_LAP2_LEMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.40:FF:000002">
        <property type="entry name" value="Thymopoietin isoform alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.40:FF:000003">
        <property type="entry name" value="thymopoietin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013146">
        <property type="entry name" value="LEM-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051656">
        <property type="entry name" value="LEM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12019">
        <property type="entry name" value="LAMINA-ASSOCIATED POLYPEPTIDE THYMOPOIETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12019:SF9">
        <property type="entry name" value="THYMOPOIETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08198">
        <property type="entry name" value="Thymopoietin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01261">
        <property type="entry name" value="Thymopoietin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50955">
        <property type="entry name" value="LEM_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="LEM-like" evidence="11">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="LEM" evidence="10">
        <location>
            <begin position="112"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000036612.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="347" mass="38685" checksum="68BBA37147B267AC" modified="2019-12-11" version="2">MPEFLEDPSVLTKDRLKSELLANNVTLPSGEQRKDVYVQLYLQHLTVRNRSAALPPPPAANSRAPPDFSSDDEREPTPVLSAAGRGRGGGGAAAGRKATKKTDKPRSEEKDDIDVSDLTNEELLSQLVKYGVNPGPIVETTRKLYEKKLLKLRDHSLESRSSTPLPTVSSSAENAKQNGNDDSDRYSDNEEELKLEKREPLKSKSKTPVTLKQRRVEHNQVGDITLTEERRIERDILKEMFPFEAATPTGISASCRRPIKGAAGRPLELGDFRMEGTFSSKYVPKYAPIADDKTEKTRKGRSIPMWIKILLFVVVAVFLFLVYQAMETNQGNPFSNFLNDESQGQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>F6YXQ4</accession>
    <name>F6YXQ4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin-dependent peroxide reductase, mitochondrial</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin-dependent peroxiredoxin 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PRDX3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer; disulfide-linked, upon oxidation. 6 homodimers assemble to form a ring-like dodecamer. Interacts with NEK6. Interacts with LRRK2. Interacts with MAP3K13. Interacts with RPS6KC1 (via PX domain).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="RefSeq" id="XP_007478982.1">
        <property type="nucleotide sequence ID" value="XM_007478920.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6YXQ4"/>
    <dbReference type="Ensembl" id="ENSMODT00000011821.4">
        <property type="protein sequence ID" value="ENSMODP00000011601.4"/>
        <property type="gene ID" value="ENSMODG00000009286.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100020372"/>
    <dbReference type="CTD" id="10935"/>
    <dbReference type="eggNOG" id="KOG0852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153430"/>
    <dbReference type="HOGENOM" id="CLU_042529_21_0_1"/>
    <dbReference type="OMA" id="KDSKQYF"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009286">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023807564" description="Thioredoxin-dependent peroxide reductase, mitochondrial" evidence="14">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="71"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011601.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="264" mass="28747" checksum="7F7DEFAB27BBA0B2" modified="2019-12-11" version="3">MLSSSLLIGIVLWVQGHLVMVARHVSSFPLGISAAFRPVATRNKFPANVVLTSAASPKSSAFSTSASAYVPAVTQHAPHFKGTAVVNGEFKEISLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVIAVSVDSQFSHLAWINTPRKSGGLGHMNIALLSDLTKQISRDYGVLLEGPGLALRGLFIIDPNGVIKHMSINDLPVGRSVEETLRLVKAFQFVEAHGEVCPANWTPDSPTIKPSPTASKEYFEKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>F7C0G0</accession>
    <name>F7C0G0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger protein 131</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ZNF131</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016287073.1">
        <property type="nucleotide sequence ID" value="XM_016431587.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056680557.1">
        <property type="nucleotide sequence ID" value="XM_056824579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7C0G0"/>
    <dbReference type="Ensembl" id="ENSMODT00000025822.4">
        <property type="protein sequence ID" value="ENSMODP00000025371.3"/>
        <property type="gene ID" value="ENSMODG00000020281.6"/>
    </dbReference>
    <dbReference type="GeneID" id="100017298"/>
    <dbReference type="CTD" id="7690"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154668"/>
    <dbReference type="HOGENOM" id="CLU_031851_0_0_1"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020281">
        <property type="expression patterns" value="Expressed in uterine wall and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18221">
        <property type="entry name" value="BTB_POZ_ZBTB35_ZNF131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000498">
        <property type="entry name" value="Putative zinc finger protein 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000539">
        <property type="entry name" value="Putative zinc finger protein 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000552">
        <property type="entry name" value="Zinc finger protein 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001928">
        <property type="entry name" value="Zinc finger protein 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000041">
        <property type="entry name" value="Zinc finger protein 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF55">
        <property type="entry name" value="ZINC FINGER PROTEIN 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="17">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="533"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000025371.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="583" mass="66412" checksum="FA502D5205D6D60F" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>F7D3Q3</accession>
    <name>F7D3Q3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MTMR4</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="3"/>
    <dbReference type="RefSeq" id="XP_007481874.1">
        <property type="nucleotide sequence ID" value="XM_007481812.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7D3Q3"/>
    <dbReference type="Ensembl" id="ENSMODT00000018705.3">
        <property type="protein sequence ID" value="ENSMODP00000018372.3"/>
        <property type="gene ID" value="ENSMODG00000014697.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100012210"/>
    <dbReference type="CTD" id="9110"/>
    <dbReference type="eggNOG" id="KOG4471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158976"/>
    <dbReference type="HOGENOM" id="CLU_001839_2_2_1"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014697">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15733">
        <property type="entry name" value="FYVE_MTMR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13342">
        <property type="entry name" value="PH-GRAM_MTMR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14587">
        <property type="entry name" value="PTP-MTMR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000073">
        <property type="entry name" value="myotubularin-related protein 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046978">
        <property type="entry name" value="MTMR4_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035997">
        <property type="entry name" value="MTMR4_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030590">
        <property type="entry name" value="MTMR4_PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF64">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="17">
        <location>
            <begin position="167"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="390"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="16">
        <location>
            <begin position="1134"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="739"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="334"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="359"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="421"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000018372.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1215" mass="136464" checksum="F2FE6A6A8EE7AE35" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>F7D417</accession>
    <name>F7D417_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 19">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="4 19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MCM5</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex. Interacts with ANKRD17. Interacts with MCMBP. Interacts with TONSL; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 19"/>
    <dbReference type="AlphaFoldDB" id="F7D417"/>
    <dbReference type="Ensembl" id="ENSMODT00000001401.6">
        <property type="protein sequence ID" value="ENSMODP00000001373.5"/>
        <property type="gene ID" value="ENSMODG00000001152.6"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286966"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001152">
        <property type="expression patterns" value="Expressed in hindlimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000005">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000006">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="21">
        <location>
            <begin position="331"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000001373.5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="704" mass="78603" checksum="B92FF9073ADB9EF6" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F7D423</accession>
    <name>F7D423_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic polyadenylation element binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CPEB2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPEB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7D423"/>
    <dbReference type="Ensembl" id="ENSMODT00000001398.4">
        <property type="protein sequence ID" value="ENSMODP00000001370.4"/>
        <property type="gene ID" value="ENSMODG00000001149.5"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160357"/>
    <dbReference type="HOGENOM" id="CLU_014948_2_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001149">
        <property type="expression patterns" value="Expressed in spermatocyte and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12724">
        <property type="entry name" value="RRM1_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12726">
        <property type="entry name" value="RRM2_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000008">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000009">
        <property type="entry name" value="cytoplasmic polyadenylation element-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF8">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="751"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="859"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000001370.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="982" mass="105264" checksum="F650045A52CF4127" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>F7DUM2</accession>
    <name>F7DUM2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NLR family member X1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NLRX1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species. Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner. In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homohexamer. Interacts with MAVS. Interacts with TUFM.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NLRP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016289286.1">
        <property type="nucleotide sequence ID" value="XM_016433800.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016289287.1">
        <property type="nucleotide sequence ID" value="XM_016433801.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7DUM2"/>
    <dbReference type="FunCoup" id="F7DUM2">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000016571"/>
    <dbReference type="Ensembl" id="ENSMODT00000016876.4">
        <property type="protein sequence ID" value="ENSMODP00000016571.3"/>
        <property type="gene ID" value="ENSMODG00000013249.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100031223"/>
    <dbReference type="KEGG" id="mdo:100031223"/>
    <dbReference type="CTD" id="79671"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159493"/>
    <dbReference type="HOGENOM" id="CLU_016769_0_0_1"/>
    <dbReference type="InParanoid" id="F7DUM2"/>
    <dbReference type="OMA" id="CVEPGHR"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013249">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032688">
        <property type="term" value="P:negative regulation of interferon-beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032715">
        <property type="term" value="P:negative regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010936">
        <property type="term" value="P:negative regulation of macrophage cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039536">
        <property type="term" value="P:negative regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001029">
        <property type="entry name" value="NLR family member X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000149">
        <property type="entry name" value="NLR family member X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048900">
        <property type="entry name" value="NLRX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21402">
        <property type="entry name" value="NLRX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NACHT" evidence="17">
        <location>
            <begin position="160"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000016571.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="975" mass="108739" checksum="A577374D13B1402F" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>F7DV52</accession>
    <name>F7DV52_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 570-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100618455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F7DV52"/>
    <dbReference type="Ensembl" id="ENSMODT00000016872.3">
        <property type="protein sequence ID" value="ENSMODP00000016567.3"/>
        <property type="gene ID" value="ENSMODG00000047407.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100618301"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164918"/>
    <dbReference type="HOGENOM" id="CLU_002678_44_0_1"/>
    <dbReference type="OrthoDB" id="6052214at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000047407">
        <property type="expression patterns" value="Expressed in uterus and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7DV52">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002577">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004091">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002573">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001402">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000592">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF462">
        <property type="entry name" value="ZINC FINGER PROTEIN 566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="7">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000016567.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="505" mass="57125" checksum="397303D47196EA42" modified="2019-12-11" version="2">MAPGTPRPPSQGSVTFQDVTMDFTQEEWRLLDHSQKELYREVMLENVQNLLSVGLPVPRENFISCFQQGKAPWLLEQKGPRSFCPEAETTFEVKEITTKLSLFVEGCGPQRCMNGSPHYFILGKIIDSNINIKKNLKNDCEIDETADKFTQYSVLNQYMKLTSGNDCCQDSEYNNCFPDEIGLIQSPKTPPKRPTYQGKLGRMALGWSLDLIRHPKSKPVDMVSVNNKGGKTSQNSDLAAHQIMHCGKKLYDCKHCGKGFTVRGSLSRHQTVHTGEKPYECKKCGKTFTQRSHLAKHQRIHSGEKPYECKPCGKAFTQRGHLAKHQRIHSGEKPYECKQCGKAFTQRGHLAKHQRIHTGEKPFECKHCGKAFTERGSLTTHQRIHTGEKPYECKQCGKVFTQRGSLATHQRIHTGEKPYACKPCGKAFKWKGSLAAHQKIHTGEKPYECKHCGRAFTRRDSLAVHQRIHTGEKPFECKQCGKAFTQRGSLAAHQKVHTGKTSCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>F7E6U1</accession>
    <name>F7E6U1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar protein sorting 4 homolog B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">VPS4B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7E6U1"/>
    <dbReference type="STRING" id="13616.ENSMODP00000006515"/>
    <dbReference type="Ensembl" id="ENSMODT00000006650.3">
        <property type="protein sequence ID" value="ENSMODP00000006515.3"/>
        <property type="gene ID" value="ENSMODG00000005285.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154973"/>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005285">
        <property type="expression patterns" value="Expressed in endometrium and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090543">
        <property type="term" value="C:Flemming body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030301">
        <property type="term" value="P:cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032510">
        <property type="term" value="P:endosome to lysosome transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904903">
        <property type="term" value="P:ESCRT III complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060856">
        <property type="term" value="P:establishment of blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061738">
        <property type="term" value="P:late endosomal microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903542">
        <property type="term" value="P:negative regulation of exosomal secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006997">
        <property type="term" value="P:nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903724">
        <property type="term" value="P:positive regulation of centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903543">
        <property type="term" value="P:positive regulation of exosomal secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051261">
        <property type="term" value="P:protein depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090611">
        <property type="term" value="P:ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046761">
        <property type="term" value="P:viral budding from plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039702">
        <property type="term" value="P:viral budding via host ESCRT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF72">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="181"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000006515.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="459" mass="50856" checksum="CE815751F133EB4B" modified="2019-12-11" version="3">DSRKLREKDRKRGRLLGVLKSPAGFCIHTVVRDPTPLWLLAFNPSLLAVGSSRRHGVYQPPDEAQGDKAKQSIRAKCAEYLDRAEKLKEYLKKKEKAPQKPVKEGQSSPADEKGNDSDGDGESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEDHARTAMFKLHLGTTHNNLSEVDFRELGKKTDGYSGADISIIVRDALMQPVRKVQSATHFKRVRGPSPTNPSVIVEDLLTPCSPGDPGAIEMTWMDVSGDKLLEPAVSMPDMLRSLASTKPTVNEHDLLKLKKFTEDFGQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>F7F9V3</accession>
    <name>F7F9V3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ceramide synthase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CERS6</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36548"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7F9V3"/>
    <dbReference type="Ensembl" id="ENSMODT00000009742.3">
        <property type="protein sequence ID" value="ENSMODP00000009554.2"/>
        <property type="gene ID" value="ENSMODG00000007694.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234515"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007694">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7F9V3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000020">
        <property type="entry name" value="Ceramide synthase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF43">
        <property type="entry name" value="CERAMIDE SYNTHASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000009554.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="356" mass="42105" checksum="1900981E95D9E9DD" modified="2019-12-11" version="2">MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFFIFMVRLVFERFIAKPCALGLNIQANGPQKAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFTFYLYVFTYGVRFLKKTPWLWNTKQCWYNYPYQPLTPDLHYYYILELSFYWSLMFSQFTDIKRKDFVIMFLHHLATISLITFSYVNNMARVGTLVMCLHDAADGLLEAAKMANYAKLQKLCDLMFVMFAIVFITTRLGIFPLWCPRMTEVILNPAQMRKIQYFLQRTHTTLPPTPMGPVAPVAQMGTSQVVHVQRNTNYFTPQDLNKVNSLLLEIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3K2</accession>
    <name>A0A5F8G3K2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SPARC related modular calcium binding 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SMOC2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3K2"/>
    <dbReference type="Ensembl" id="ENSMODT00000073004.1">
        <property type="protein sequence ID" value="ENSMODP00000042058.1"/>
        <property type="gene ID" value="ENSMODG00000005807.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018436"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005807">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16241">
        <property type="entry name" value="EFh_SPARC_SMOC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000076">
        <property type="entry name" value="SPARC-related modular calcium binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000012">
        <property type="entry name" value="SPARC-related modular calcium binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000004">
        <property type="entry name" value="SPARC-related modular calcium-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037640">
        <property type="entry name" value="SMOC2_EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF21">
        <property type="entry name" value="SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16597">
        <property type="entry name" value="Thyroglob_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023813193" evidence="12">
        <location>
            <begin position="30"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="15">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="14">
        <location>
            <begin position="95"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="14">
        <location>
            <begin position="240"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="374"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="411"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="443"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="278"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="473" mass="53098" checksum="C223DBC3CBCBD53B" modified="2019-12-11" version="1">MSSLRVRMLFPKIWWLLLLLPELLLLVPAQKFSALTFLRVDQDKDKECSLDCAGSPQKSLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAERKYTQEQARKEFQQVFIPECNDDGTYSQRSLFFVKVTKPFEGGRGKKVQCHSYTGYCWCVTPNGRPISGTAVAHKTPRCPGSITEKLPQREGTGKADDASAPALETQPQGDEEDIASRYPTLWTEQVKSRQNKTNKNSASSCDQEHQSALEEAKQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKCDNTARAHPTKTKDLYKGRQLQGCPGAKKNEFLTSVLDALSTDMVHAVSDPSSSSSRLSEPDPSHTLEERVVHWYFKLLDKNSSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDVNNDKSISVQELMGCLGVTKEEGKANTKKRHTPKTNSESTSNRQPKKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3K3</accession>
    <name>A0A5F8G3K3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NIPA magnesium transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NIPA2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3K3"/>
    <dbReference type="Ensembl" id="ENSMODT00000054242.1">
        <property type="protein sequence ID" value="ENSMODP00000042049.1"/>
        <property type="gene ID" value="ENSMODG00000000565.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155651"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000565">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="341" mass="36999" checksum="0C8F0206A6E3E3CB" modified="2019-12-11" version="1">MSHDRGKYDFYVGLGLAMSSSIFIGGSFILKKKGLLRLARKGSMRAVGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLIVIVSLILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKPVLRHPLSWILLLSLILCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQNMPVDDIIGTLSGFLTIIVGIFLLHAFKDVSFSLASLPVSLRKDEKVVNGNLSNLYEVLNNNEGNLACGSEQQTGENISRRNGNLMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3K4</accession>
    <name>A0A5F8G3K4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PEX7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3K4"/>
    <dbReference type="Ensembl" id="ENSMODT00000087919.1">
        <property type="protein sequence ID" value="ENSMODP00000042016.1"/>
        <property type="gene ID" value="ENSMODG00000017434.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157264"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017434">
        <property type="expression patterns" value="Expressed in placenta and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="238"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="327" mass="36504" checksum="0E57536E3A61523E" modified="2019-12-11" version="1">MSAAPGGGAQTLRTPGRHGYAVEFSPYLPGRLACATSQYYGIAGCGTLIVLEQNEAGVGHFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAEATGPLQVFKEHTQEVYSVDWSQTRGEQLVVSGSWDQTAKLWDPTVGKSLCTFRGHEGVIYSTIWSPHIPGCFASTSGDQTLRVWDVKTSGVKIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNIRQPVFELLGHAYAIRRVKFSPFHASLLASCSYDFTVRFWNFSKPNPLLETVEHHTEFTCGLDLSLHSPTQVVLTEERLQYGSWRRLKRAPRSPFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3K5</accession>
    <name>A0A5F8G3K5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminomethyltransferase</fullName>
            <ecNumber evidence="11">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AMT</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3K5"/>
    <dbReference type="Ensembl" id="ENSMODT00000066006.1">
        <property type="protein sequence ID" value="ENSMODP00000041995.1"/>
        <property type="gene ID" value="ENSMODG00000012973.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157524"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012973">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000014">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF16">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="12">
        <location>
            <begin position="58"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="13">
        <location>
            <begin position="261"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="346" mass="37729" checksum="454398A75CDEE0AF" modified="2019-12-11" version="1">EALKKTPLFDFHKSHGGKMVSFAGWSLPVQYQDSHLESHLHTRRHCSLFDVSHMLQGTLTLFTNEEGGIIDDLIVTNTSDKYLYVVSNAGCREKDLALMQNKASELRSAGWDVNLEVTDHALMALQGPSAAHVLQAGVSDDLRKLTFMTSAVMDVFGVPGCRVTRCGYTGEDGVEISVPAEKAVHLAEALLKNQEVKLAGLAARDSLRLEAGLCLYGNDIDERTTPVEGSLGWTLGKRRRAAMDFPGAAIVVPQIKGKLTRKRVGLTSTGAPIRQHSLIMNTEGAVIGEITSGCPSPCLKKNVAMGYVDGQYSKIGTPLMVEVRKKQQEAVVSKMPFVPTRYYTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3L0</accession>
    <name>A0A5F8G3L0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family with sequence similarity 104 member A</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3L0"/>
    <dbReference type="Ensembl" id="ENSMODT00000059185.1">
        <property type="protein sequence ID" value="ENSMODP00000042037.1"/>
        <property type="gene ID" value="ENSMODG00000038809.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100023913"/>
    <dbReference type="GeneTree" id="ENSGT00390000001055"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000038809">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029222">
        <property type="entry name" value="VCF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34763">
        <property type="entry name" value="PROTEIN FAM104A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34763:SF1">
        <property type="entry name" value="PROTEIN FAM104A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15434">
        <property type="entry name" value="FAM104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="139" mass="15351" checksum="2B068FB5E573D098" modified="2019-12-11" version="1">MNLIRKRRRNGNEEDSHLPQTKRSSRNPVFQDSWDTETAPVTKNSKENRLRGNKVFCASSSSDSGGSSSSSSTSSSINSPDRGSVQESSLNQIITGSSPNTPQSLQEQSALCQGPYFHINQILKEAHFYSLQHRGRPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3L1</accession>
    <name>A0A5F8G3L1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPL8</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the large ribosomal subunit. Interacts with CRY1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3L1"/>
    <dbReference type="Ensembl" id="ENSMODT00000067486.1">
        <property type="protein sequence ID" value="ENSMODP00000042021.1"/>
        <property type="gene ID" value="ENSMODG00000004283.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153244"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004283">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="148" mass="16166" checksum="362B0C4506E85956" modified="2019-12-11" version="1">MGRVIRGQRKGAGSVFRAHVKHRKGAAKLRAVDFAERHGYIKGIVKKVISSANRAIVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAARRTGRLRGTKTVQEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3L2</accession>
    <name>A0A5F8G3L2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 6 open reading frame 62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">C6orf62</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3L2"/>
    <dbReference type="Ensembl" id="ENSMODT00000072352.1">
        <property type="protein sequence ID" value="ENSMODP00000042068.1"/>
        <property type="gene ID" value="ENSMODG00000011671.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008115"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011671">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027903">
        <property type="entry name" value="DUF4566"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15130">
        <property type="entry name" value="DUF4566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="200" mass="23494" checksum="B17E3550ED6C297D" modified="2019-12-11" version="1">MNETPSDPKYPVVRKKKSALFEVSEVIPVMTNNYEENILKGVRDSSYTLESSIELLQKDVVQLHAPRYQSMRRDVIGCTQEMDFILWPRNDIEKIVCLLFSRWKGSDEPFRPVQAKFEFYHGDYEKQFLHVLSRKDKTGIVVNNPNQSVFLFIDRQHLQTPKNKATIFKLCSICLYLPQEQLTHWAVGTVEDHLRPYMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3L3</accession>
    <name>A0A5F8G3L3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC100012910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Ubiquitin-like protein that plays a role in cell proliferation and sister chromatid cohesion by associating with spliceosomal proteins. Participates thereby in pre-mRNA splicing by maintaining spliceosome integrity. Promotes the functional integrity of the Fanconi anemia DNA repair pathway by interacting with FANCI component and subsequently mediating the formation of FANCI homodimers. Also plays a protective role against ER stress-induced apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with CLK1, CLK3 and CLK4. Interacts with coilin/COIL. Interacts with spliceosome components SART1 and EFTUD2. Interacts with FANCI; this interaction promotes FANCI dimerization.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001363779.1">
        <property type="nucleotide sequence ID" value="XM_001363742.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3L3"/>
    <dbReference type="Ensembl" id="ENSMODT00000057416.1">
        <property type="protein sequence ID" value="ENSMODP00000042059.1"/>
        <property type="gene ID" value="ENSMODG00000037364.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100012910"/>
    <dbReference type="KEGG" id="mdo:100012910"/>
    <dbReference type="GeneTree" id="ENSGT00390000001945"/>
    <dbReference type="OMA" id="GMSLEMQ"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000037364">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000052">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="73" mass="8547" checksum="D68ECC41536FF39F" modified="2019-12-11" version="1">MIEVVCNDRLGKKVRVKCNTDDSIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVTLGDYEIHDGMNLELYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3L6</accession>
    <name>A0A5F8G3L6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyadenylate-binding protein</fullName>
            <shortName evidence="7">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PABPC4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3L6"/>
    <dbReference type="Ensembl" id="ENSMODT00000082532.1">
        <property type="protein sequence ID" value="ENSMODP00000042026.1"/>
        <property type="gene ID" value="ENSMODG00000017657.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154788"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017657">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000001">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000042">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000154">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="74"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="166"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="269"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="9">
        <location>
            <begin position="426"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="518" mass="58198" checksum="209A5FBBE53FFED2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3L7</accession>
    <name>A0A5F8G3L7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="25">MBL associated serine protease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">MASP1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="18">The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3L7"/>
    <dbReference type="Ensembl" id="ENSMODT00000080282.1">
        <property type="protein sequence ID" value="ENSMODP00000042073.1"/>
        <property type="gene ID" value="ENSMODG00000008535.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183084"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008535">
        <property type="expression patterns" value="Expressed in liver and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006956">
        <property type="term" value="P:complement activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000059">
        <property type="entry name" value="Mannan-binding lectin serine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000006">
        <property type="entry name" value="Mannan-binding lectin serine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000050">
        <property type="entry name" value="mannan-binding lectin serine protease 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000028">
        <property type="entry name" value="mannan-binding lectin serine protease 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024175">
        <property type="entry name" value="Pept_S1A_C1r/C1S/mannan-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF13">
        <property type="entry name" value="MANNAN-BINDING LECTIN SERINE PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001155">
        <property type="entry name" value="C1r_C1s_MASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 17 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 18" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 21" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="CUB" evidence="22">
        <location>
            <begin position="72"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="24">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="23">
        <location>
            <begin position="329"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="(3R)-3-hydroxyasparagine" evidence="18">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17 20">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="188"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (between heavy and light chains)" evidence="17">
        <location>
            <begin position="315"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="539"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001155-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001155-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001155-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001155-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="609" mass="67522" checksum="5C4F935427444329" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3L8</accession>
    <name>A0A5F8G3L8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000065056.1">
        <property type="protein sequence ID" value="ENSMODP00000042064.1"/>
        <property type="gene ID" value="ENSMODG00000009313.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160294"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009313">
        <property type="expression patterns" value="Expressed in lung and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031091">
        <property type="term" value="C:platelet alpha granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000028">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000011">
        <property type="entry name" value="Coagulation factor VIII (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024715">
        <property type="entry name" value="Factor_5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF7">
        <property type="entry name" value="COAGULATION FACTOR VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000354">
        <property type="entry name" value="Factors_V_VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023934853" description="F5/8 type C domain-containing protein" evidence="12">
        <location>
            <begin position="20"/>
            <end position="2202"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="1891"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="2044"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="751"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1062"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1130"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1178"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1321"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1400"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1601"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1204"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1329"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1353"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1400"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1607"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1628"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="257"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="641"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1891"/>
            <end position="2039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000354-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2202" mass="243260" checksum="79A761B4AFFC4F88" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3M0</accession>
    <name>A0A5F8G3M0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 170A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CFDP1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3M0"/>
    <dbReference type="Ensembl" id="ENSMODT00000071966.1">
        <property type="protein sequence ID" value="ENSMODP00000042010.1"/>
        <property type="gene ID" value="ENSMODG00000002164.4"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100021156"/>
    <dbReference type="GeneTree" id="ENSGT00390000018141"/>
    <dbReference type="OMA" id="GRFMSVG"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002164">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 170A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="144" mass="15119" checksum="B52FE02EE236E92A" modified="2019-12-11" version="1">MESEGSGGSGGSAGLLQQILSLKLVPRVGNGTLCPNSTSLCSFPEMWYGVFLWALVSSLSFHVPAGLLALFTLRHHKYGRFMSVSILLMGIVGPITAGILTSAAIAGVYRAAGKEMIPFEALTLGVGQTFCVVVVSFLRILATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3M3</accession>
    <name>A0A5F8G3M3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Interleukin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">IL15</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the IL-15/IL-21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007496356.1">
        <property type="nucleotide sequence ID" value="XM_007496294.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007496357.1">
        <property type="nucleotide sequence ID" value="XM_007496295.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016278687.1">
        <property type="nucleotide sequence ID" value="XM_016423201.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3M3"/>
    <dbReference type="FunCoup" id="A0A5F8G3M3">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042052"/>
    <dbReference type="Ensembl" id="ENSMODT00000087909.1">
        <property type="protein sequence ID" value="ENSMODP00000042052.1"/>
        <property type="gene ID" value="ENSMODG00000041399.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103092205"/>
    <dbReference type="KEGG" id="mdo:103092205"/>
    <dbReference type="CTD" id="3600"/>
    <dbReference type="GeneTree" id="ENSGT00390000016264"/>
    <dbReference type="InParanoid" id="A0A5F8G3M3"/>
    <dbReference type="OMA" id="FVWGCIS"/>
    <dbReference type="OrthoDB" id="8905762at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000041399">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035723">
        <property type="term" value="P:interleukin-15-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030225">
        <property type="term" value="P:macrophage differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042119">
        <property type="term" value="P:neutrophil activation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001819">
        <property type="term" value="P:positive regulation of cytokine production"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050778">
        <property type="term" value="P:positive regulation of immune response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032740">
        <property type="term" value="P:positive regulation of interleukin-17 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050766">
        <property type="term" value="P:positive regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.70">
        <property type="entry name" value="Interleukin-15/Interleukin-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020439">
        <property type="entry name" value="IL-15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003443">
        <property type="entry name" value="IL-15/IL-21_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14356:SF3">
        <property type="entry name" value="INTERLEUKIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14356">
        <property type="entry name" value="INTERLEUKIN-15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02372">
        <property type="entry name" value="IL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01930">
        <property type="entry name" value="INTRLEUKIN15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="183" mass="20777" checksum="8DA498D9EBA48FDC" modified="2019-12-11" version="1">MLVMSRAPQKTTRAYSRPIRGRKSYLRSSPIQCYLYLILNGHFFSFLTEAGTHFFILSCISAHLPKTEASNWEFVIRDLELLKDLTNKTDISSLYTESDAHPSCKITMLSCFLQELHVISYESNNDEINQTVENIIILASSTLSSDENKAESGCKECEELEEKNVGEFLKSFTHMVQSFIGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3M4</accession>
    <name>A0A5F8G3M4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 107 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM107B</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3M4"/>
    <dbReference type="FunCoup" id="A0A5F8G3M4">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042069"/>
    <dbReference type="Ensembl" id="ENSMODT00000080298.1">
        <property type="protein sequence ID" value="ENSMODP00000042069.1"/>
        <property type="gene ID" value="ENSMODG00000016919.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011228"/>
    <dbReference type="InParanoid" id="A0A5F8G3M4"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016919">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009533">
        <property type="entry name" value="FAM107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768">
        <property type="entry name" value="DOWN REGULATED IN RENAL CARCINOMA 1/TU3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768:SF1">
        <property type="entry name" value="PROTEIN FAM107B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06625">
        <property type="entry name" value="DUF1151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="184" mass="21585" checksum="DF491B5FB112801A" modified="2019-12-11" version="1">MAWKGLALESEDRGSSTFSVIVKCFAEFEVLPKYNIIEDPELKDSILIQKSIMAEPDYIEDDNPELIKPQKLINPVKISRNHQDLHRELLMNQKRGLAPQNKPELQRVMEKRKRDQVIKQQKEEEAQKKKSDLEIELLKRQQKLEQLELEKQKIQEEQENAPEFVKVKGNLRRTGQEVAEVQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3M5</accession>
    <name>A0A5F8G3M5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="22">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">ATP8A2</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 22">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Membrane</location>
            <topology evidence="2 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 22">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="22"/>
    <dbReference type="RefSeq" id="XP_056650674.1">
        <property type="nucleotide sequence ID" value="XM_056794696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3M5"/>
    <dbReference type="Ensembl" id="ENSMODT00000079291.1">
        <property type="protein sequence ID" value="ENSMODP00000042015.1"/>
        <property type="gene ID" value="ENSMODG00000008674.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100024643"/>
    <dbReference type="CTD" id="51761"/>
    <dbReference type="GeneTree" id="ENSGT00940000157332"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008674">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF98">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 21 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 20 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 22" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="887"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="914"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="956"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="997"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1029"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1064"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="23">
        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="25">
        <location>
            <begin position="848"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="795"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="801"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="821"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1153" mass="129757" checksum="10DC6259B62A95F5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3M6</accession>
    <name>A0A5F8G3M6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">trypsin</fullName>
            <ecNumber evidence="9">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100010109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3M6"/>
    <dbReference type="Ensembl" id="ENSMODT00000081522.1">
        <property type="protein sequence ID" value="ENSMODP00000042036.1"/>
        <property type="gene ID" value="ENSMODG00000043441.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244883"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000043441">
        <property type="expression patterns" value="Expressed in liver and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000005">
        <property type="entry name" value="Serine protease 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF15">
        <property type="entry name" value="RIKEN CDNA 2210010C04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0222">Digestion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="254" mass="27504" checksum="60B610CE33525F9B" modified="2019-12-11" version="1">MNNELLGAYPTRNDDDKIFGGYTCAANSVPYQVSLNAGYHFCGGSLINSQWVVSAKEKRKMEIGLLKSDRFCPSSQIQVRLGEHNNDILEGNEQFIDSAKVIRHPKYNSNTIDNDIMLIKLKTPATLNSRVSSITLPTSCAATGTSCLISGWGNTLSSGSNYTELLQCLKAPVLSDSSCRNAYPGQITNNMICLGYLEGGKDSCQEDSGGPVVCDGELQGIVSWGYGCAQKGKPGVYTKVCNYVDWIKTTIANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3M7</accession>
    <name>A0A5F8G3M7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC1 domain family member 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TBC1D14</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3M7"/>
    <dbReference type="FunCoup" id="A0A5F8G3M7">
        <property type="interactions" value="1200"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042057"/>
    <dbReference type="Ensembl" id="ENSMODT00000061825.1">
        <property type="protein sequence ID" value="ENSMODP00000042057.1"/>
        <property type="gene ID" value="ENSMODG00000002932.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157250"/>
    <dbReference type="InParanoid" id="A0A5F8G3M7"/>
    <dbReference type="OMA" id="NTEREHR"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002932">
        <property type="expression patterns" value="Expressed in kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071955">
        <property type="term" value="P:recycling endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000785">
        <property type="term" value="P:regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000008">
        <property type="entry name" value="Putative TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000005">
        <property type="entry name" value="TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000006">
        <property type="entry name" value="TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF21">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="441"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="742" mass="84158" checksum="DCD06B25BDDC23FC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3M8</accession>
    <name>A0A5F8G3M8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">MOCOS</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3M8"/>
    <dbReference type="Ensembl" id="ENSMODT00000064577.1">
        <property type="protein sequence ID" value="ENSMODP00000042083.1"/>
        <property type="gene ID" value="ENSMODG00000000387.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157051"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000387">
        <property type="expression patterns" value="Expressed in liver and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="5">
        <location>
            <begin position="637"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="806" mass="89842" checksum="720A6DD3971A4EAD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3M9</accession>
    <name>A0A5F8G3M9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Formin binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">FNBP1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FNBP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3M9"/>
    <dbReference type="Ensembl" id="ENSMODT00000073947.1">
        <property type="protein sequence ID" value="ENSMODP00000042074.1"/>
        <property type="gene ID" value="ENSMODG00000006998.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183047"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006998">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07676">
        <property type="entry name" value="F-BAR_FBP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000002">
        <property type="entry name" value="Formin-binding protein 1-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000017">
        <property type="entry name" value="Formin-binding protein 1-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037449">
        <property type="entry name" value="FNBP1_F-BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF13">
        <property type="entry name" value="FORMIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="18">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="19">
        <location>
            <begin position="343"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="489"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="428"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="556" mass="64909" checksum="95BC537CD9B489FC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3N0</accession>
    <name>A0A5F8G3N0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein 4.1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Band 4.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Erythrocyte membrane protein band 4.1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">EPB41</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3N0"/>
    <dbReference type="Ensembl" id="ENSMODT00000059455.1">
        <property type="protein sequence ID" value="ENSMODP00000042041.1"/>
        <property type="gene ID" value="ENSMODG00000011038.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157833"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011038">
        <property type="expression patterns" value="Expressed in blood and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13184">
        <property type="entry name" value="FERM_C_4_1_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008379">
        <property type="entry name" value="Band_4.1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007477">
        <property type="entry name" value="SAB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF12">
        <property type="entry name" value="PROTEIN 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05902">
        <property type="entry name" value="4_1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04382">
        <property type="entry name" value="SAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002304">
        <property type="entry name" value="Membrane_skeletal_4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FERM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="269"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="691" mass="77305" checksum="C7F66582D2BB5290" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3N1</accession>
    <name>A0A5F8G3N1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AU RNA binding methylglutaconyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">AUH</name>
        <name evidence="2" type="synonym">LOC100028211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3N1"/>
    <dbReference type="Ensembl" id="ENSMODT00000075419.1">
        <property type="protein sequence ID" value="ENSMODP00000042020.1"/>
        <property type="gene ID" value="ENSMODG00000019240.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157484"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019240">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000211">
        <property type="entry name" value="AUH protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF12">
        <property type="entry name" value="METHYLGLUTACONYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="344" mass="37153" checksum="EABFE1A3375D8E0B" modified="2019-12-11" version="1">MAVAGGLGVLQGCRVRLLAAYFARLGPGLVTRGSGQRLWRTSERRCWPSVSAGSGLSRSYGSEAKGDEELRVRYLEEENKGIVVLGINRSYAKNSLSKNLIKMLSKAVDALKSDKKVRTIIVRSEVPGIFCAGADLKERAQMSLSEVSSFVSKARTLMNEMGGTQRLPRAIGMALAKEMIFSARVLNGQEAKSIGLISHVLEQNEAGDAAYRKALALAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQVILKVKLHLGTFPKRMFGNSRLSTVEGRHSSPFASPSQRSCLPRADVCSVFGDSLEMTPARATKRDRASFFGLESPGQRSSEAAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3N2</accession>
    <name>A0A5F8G3N2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Low-density lipoprotein receptor-related protein 1B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Low-density lipoprotein receptor-related protein-deleted in tumor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LRP1B</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000058416.1">
        <property type="protein sequence ID" value="ENSMODP00000042062.1"/>
        <property type="gene ID" value="ENSMODG00000002847.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157521"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002847">
        <property type="expression patterns" value="Expressed in spinal cord and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000022">
        <property type="entry name" value="LDL receptor related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000504">
        <property type="entry name" value="LDL receptor related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000012">
        <property type="entry name" value="Low density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000007">
        <property type="entry name" value="Low density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000010">
        <property type="entry name" value="Low density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000024">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000129">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000144">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000505">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000014">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000015">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000018">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000019">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000001">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000004">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000010">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000012">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000015">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000018">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000072">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000498">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000061">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000070">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000073">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000080">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000081">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000101">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000102">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000107">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000110">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000123">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000020">
        <property type="entry name" value="Prolow-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000009">
        <property type="entry name" value="Putative low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF5">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 18" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="4379"/>
            <end position="4402"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="235"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="279"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="465"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="508"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="554"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="604"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="1197"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="1244"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="1287"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="1515"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="1602"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="1819"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="1862"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="1905"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="2227"/>
            <end position="2271"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="2996"/>
            <end position="3038"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="3039"/>
            <end position="3082"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="3936"/>
            <end position="3979"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4110"/>
            <end position="4143"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4146"/>
            <end position="4182"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4183"/>
            <end position="4218"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4219"/>
            <end position="4254"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4289"/>
            <end position="4324"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4326"/>
            <end position="4362"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="790"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="831"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="872"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="970"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1013"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2415"/>
            <end position="2433"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2449"/>
            <end position="2461"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2456"/>
            <end position="2474"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2468"/>
            <end position="2483"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2488"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2495"/>
            <end position="2513"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2507"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2556"/>
            <end position="2571"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2579"/>
            <end position="2591"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2586"/>
            <end position="2604"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2598"/>
            <end position="2613"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2617"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2624"/>
            <end position="2642"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2702"/>
            <end position="2714"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2709"/>
            <end position="2727"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2742"/>
            <end position="2754"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2788"/>
            <end position="2800"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2795"/>
            <end position="2813"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2807"/>
            <end position="2822"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3214"/>
            <end position="3226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3221"/>
            <end position="3239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3254"/>
            <end position="3266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3261"/>
            <end position="3279"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3273"/>
            <end position="3288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3313"/>
            <end position="3328"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3353"/>
            <end position="3368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3373"/>
            <end position="3385"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3380"/>
            <end position="3398"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3392"/>
            <end position="3407"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3412"/>
            <end position="3424"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3419"/>
            <end position="3437"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3431"/>
            <end position="3446"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3450"/>
            <end position="3462"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3457"/>
            <end position="3475"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3469"/>
            <end position="3484"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3491"/>
            <end position="3503"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3498"/>
            <end position="3516"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3510"/>
            <end position="3525"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3549"/>
            <end position="3564"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3571"/>
            <end position="3583"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3578"/>
            <end position="3596"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3633"/>
            <end position="3648"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3659"/>
            <end position="3671"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3666"/>
            <end position="3684"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="3678"/>
            <end position="3693"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4114"/>
            <end position="4124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4150"/>
            <end position="4160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4172"/>
            <end position="4181"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4186"/>
            <end position="4196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4208"/>
            <end position="4217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4222"/>
            <end position="4232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4244"/>
            <end position="4253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4291"/>
            <end position="4301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4295"/>
            <end position="4312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4314"/>
            <end position="4323"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4330"/>
            <end position="4340"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4352"/>
            <end position="4361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="4534" mass="507719" checksum="32D43AA4FB0A05A3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3N3</accession>
    <name>A0A5F8G3N3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-phase cyclin A associated protein in the ER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SCAPER</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000068580.1">
        <property type="protein sequence ID" value="ENSMODP00000042088.1"/>
        <property type="gene ID" value="ENSMODG00000012042.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011159"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012042">
        <property type="expression patterns" value="Expressed in testis and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000680">
        <property type="entry name" value="S phase cyclin A-associated protein in the endoplasmic reticulum"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032446">
        <property type="entry name" value="SCAPER_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434:SF2">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16501">
        <property type="entry name" value="SCAPER_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U1-type" evidence="3">
        <location>
            <begin position="829"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1423"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1442" mass="162152" checksum="C6BC5667204DC565" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3N5</accession>
    <name>A0A5F8G3N5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">3'-phosphoadenosine 5'-phosphosulfate synthase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PAPSS2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; sulfate assimilation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007478379.1">
        <property type="nucleotide sequence ID" value="XM_007478317.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3N5"/>
    <dbReference type="FunCoup" id="A0A5F8G3N5">
        <property type="interactions" value="644"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042046"/>
    <dbReference type="Ensembl" id="ENSMODT00000081208.1">
        <property type="protein sequence ID" value="ENSMODP00000042046.1"/>
        <property type="gene ID" value="ENSMODG00000016494.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022288"/>
    <dbReference type="KEGG" id="mdo:100022288"/>
    <dbReference type="CTD" id="9060"/>
    <dbReference type="GeneTree" id="ENSGT00390000009613"/>
    <dbReference type="InParanoid" id="A0A5F8G3N5"/>
    <dbReference type="OMA" id="IEIYKHH"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016494">
        <property type="expression patterns" value="Expressed in lung and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050428">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042445">
        <property type="term" value="P:hormone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000001">
        <property type="entry name" value="bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000006">
        <property type="entry name" value="bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF16">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="41"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="223"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="389"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="620" mass="69865" checksum="632BF3D2E3A19A9C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3N6</accession>
    <name>A0A5F8G3N6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">3'(2'), 5'-bisphosphate nucleotidase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Inositol monophosphatase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Myo-inositol monophosphatase A3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Phosphoadenosine phosphate 3'-nucleotidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BPNT2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 23">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Golgi apparatus</location>
            <location evidence="16">trans-Golgi network membrane</location>
            <topology evidence="16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3N6"/>
    <dbReference type="Ensembl" id="ENSMODT00000057832.1">
        <property type="protein sequence ID" value="ENSMODP00000042025.1"/>
        <property type="gene ID" value="ENSMODG00000008961.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160216"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008961">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01640">
        <property type="entry name" value="IPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000012">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000007">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF6">
        <property type="entry name" value="GOLGI-RESIDENT ADENOSINE 3',5'-BISPHOSPHATE 3'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="345" mass="38408" checksum="8A6D35F17F2265A4" modified="2019-12-11" version="1">MPHPHLQTGGRHISKVERQLRPLRPPPVRNPDTHPLLPFHLSLLLANVEGKDPAGRWEQDPAALPLLLSRRVAETWNGSRRPERPQWLQARLAVPLGVRREKKLPLLCLQEPRARINTEEHVDAADQEVILWDHNIPEDILREITKPKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGEPVLGVIHKPFSAYTAWAMVDGGSNVKARTSYNEKTPRIIVSRSHSGTVKQVALQTFGNQTTIIPAGGAGYKVLSLLDVPDENQEKADIYIHVTYIKKWDICAGNALLKALGGHMTTLSGEEISYTGSDGNEGGLLASINMNHQALVRKLPDLEKTSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3N9</accession>
    <name>A0A5F8G3N9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MED14</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000072186.1">
        <property type="protein sequence ID" value="ENSMODP00000042067.1"/>
        <property type="gene ID" value="ENSMODG00000021099.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001021"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021099">
        <property type="expression patterns" value="Expressed in forelimb bud and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056877">
        <property type="entry name" value="Med14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055113">
        <property type="entry name" value="Med14_RM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055114">
        <property type="entry name" value="Med14_RM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055107">
        <property type="entry name" value="Med14_RM8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056878">
        <property type="entry name" value="RM5_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25069">
        <property type="entry name" value="Med14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22981">
        <property type="entry name" value="RM2_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25067">
        <property type="entry name" value="RM5_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22984">
        <property type="entry name" value="RM6_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22983">
        <property type="entry name" value="RM8_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM2" evidence="11">
        <location>
            <begin position="215"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM5" evidence="14">
        <location>
            <begin position="522"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM6" evidence="13">
        <location>
            <begin position="651"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM8" evidence="12">
        <location>
            <begin position="1078"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 C-terminal" evidence="15">
        <location>
            <begin position="1164"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="829"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="882"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1312" mass="145867" checksum="A8D5AFE31FF4BB23" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUN4</accession>
    <name>A0A5F8GUN4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Teneurin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Protein Odd Oz/ten-m homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Tenascin-M1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Teneurin transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="primary">TENM1</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Induces gene transcription activation.</text>
    </comment>
    <comment type="function">
        <text evidence="23">Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer.</text>
    </comment>
    <comment type="function">
        <text evidence="25">Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Also acts as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tenascin family. Teneurin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000062857.1">
        <property type="protein sequence ID" value="ENSMODP00000051212.1"/>
        <property type="gene ID" value="ENSMODG00000014906.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234566"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014906">
        <property type="expression patterns" value="Expressed in cerebellum and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.180.10.10:FF:000019">
        <property type="entry name" value="Teneurin transmembrane protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000016">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000021">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000013">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000005">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000006">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000169">
        <property type="entry name" value="teneurin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000008">
        <property type="entry name" value="teneurin-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057627">
        <property type="entry name" value="FN-plug_TEN1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009471">
        <property type="entry name" value="Ten_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056822">
        <property type="entry name" value="TEN_NHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056820">
        <property type="entry name" value="TEN_TTR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057629">
        <property type="entry name" value="Teneurin1-4_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028916">
        <property type="entry name" value="Tox-GHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF7">
        <property type="entry name" value="TENEURIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24329">
        <property type="entry name" value="FN-plug_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23093">
        <property type="entry name" value="GBD_Tenm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06484">
        <property type="entry name" value="Ten_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25021">
        <property type="entry name" value="TEN_NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23538">
        <property type="entry name" value="Teneurin_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15636">
        <property type="entry name" value="Tox-GHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25020">
        <property type="entry name" value="TTR_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51361">
        <property type="entry name" value="TENEURIN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17 30" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 30" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0678">Repressor</keyword>
    <keyword evidence="15" id="KW-0346">Stress response</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 32" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Teneurin N-terminal" evidence="34">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="33">
        <location>
            <begin position="573"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="33">
        <location>
            <begin position="742"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="133"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="31">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="31">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="30">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="30">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="30">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00053699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00057184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00058594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00068164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00077043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00081437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00083965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS51361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2706" mass="302587" checksum="5E7E94FCC49E8B79" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUN5</accession>
    <name>A0A5F8GUN5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription initiation factor TFIID subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TAF1 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000073279.1">
        <property type="protein sequence ID" value="ENSMODP00000050921.1"/>
        <property type="gene ID" value="ENSMODG00000004570.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155242"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004570">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05511">
        <property type="entry name" value="Bromo_TFIID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1100.10:FF:000001">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000019">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000020">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1100.10">
        <property type="entry name" value="TAFII-230 TBP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011177">
        <property type="entry name" value="TAF1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009067">
        <property type="entry name" value="TAF_II_230-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036741">
        <property type="entry name" value="TAFII-230_TBP-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09247">
        <property type="entry name" value="TBP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003047">
        <property type="entry name" value="TAF1_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47055">
        <property type="entry name" value="TAF(II)230 TBP-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="1397"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="1520"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="118"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="966"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1104"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1233"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1629"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1736"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1474"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1115"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1233"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1638"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1651"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1688"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1736"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1811"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1364"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR003047-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR003047-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1859" mass="211273" checksum="B08E5E9EF8023B62" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUP0</accession>
    <name>A0A5F8GUP0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sperm associated antigen 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SPAG9</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JIP scaffold family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007481926.1">
        <property type="nucleotide sequence ID" value="XM_007481864.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUP0"/>
    <dbReference type="Ensembl" id="ENSMODT00000071016.1">
        <property type="protein sequence ID" value="ENSMODP00000051217.1"/>
        <property type="gene ID" value="ENSMODG00000012665.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100012908"/>
    <dbReference type="CTD" id="9043"/>
    <dbReference type="GeneTree" id="ENSGT00940000153496"/>
    <dbReference type="OrthoDB" id="10256043at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012665">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1000:FF:000001">
        <property type="entry name" value="C-Jun-amino-terminal kinase-interacting protein 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000700">
        <property type="entry name" value="Sperm-associated antigen 9a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1000">
        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039911">
        <property type="entry name" value="JIP3/JIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032486">
        <property type="entry name" value="JIP_LZII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886:SF2">
        <property type="entry name" value="C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886">
        <property type="entry name" value="JNK/SAPK-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16471">
        <property type="entry name" value="JIP_LZII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="8">
        <location>
            <begin position="341"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1080"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1161" mass="127058" checksum="54DF692FA8D985C4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUP1</accession>
    <name>A0A5F8GUP1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 25">Glycerol-3-phosphate acyltransferase 1, mitochondrial</fullName>
            <ecNumber evidence="5 25">2.3.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">GPAM</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids. Esterifies acyl-group from acyl-coenzyme A (acyl-CoA) to the sn-1 position of glycerol-3-phosphate, to produce lysophosphatidic acid. Has a narrow hydrophobic binding cleft that selects for a linear acyl chain. Catalytic activity is higher for substrates with a 16-carbon acyl chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:74547"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:37204"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA</text>
            <dbReference type="Rhea" id="RHEA:33203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:64840"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:33204"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn-glycerol 3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:35727"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:72682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:35728"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37199"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:37200"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:15325"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="2.3.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>sn-glycerol 3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:35723"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:35724"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>sn-glycerol 3-phosphate + octadecanoyl-CoA = 1-octadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37195"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:74565"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:37196"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 25">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.15" evidence="5 25"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUP1"/>
    <dbReference type="Ensembl" id="ENSMODT00000069580.1">
        <property type="protein sequence ID" value="ENSMODP00000051353.1"/>
        <property type="gene ID" value="ENSMODG00000010326.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00520000055570"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010326">
        <property type="expression patterns" value="Expressed in liver and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028354">
        <property type="entry name" value="GPAT_PlsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF16">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500064">
        <property type="entry name" value="GPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000437">
        <property type="entry name" value="GPAT_DHAPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="17 25" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 25" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 25" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 25" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15 25" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 25" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 25" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="27">
        <location>
            <begin position="225"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="669"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="26">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRNR" id="PIRNR000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="713" mass="80716" checksum="AD43D4DF71BAFDA4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUP2</accession>
    <name>A0A5F8GUP2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">StAR-related lipid transfer protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">START domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">STARD3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>cholesterol(in) = cholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:39747"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Interacts (via the MENTAL domain) with STARD3NL. Interacts (via phosphorylated FFAT motif) with VAPA (via MSP domain). Interacts (via phosphorylated FFAT motif) with VAPB (via MSP domain). Interacts (via phosphorylated FFAT motif) with MOSPD2 (via MSP domain); this interaction allows enrichment of MOSPD2 around endosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STARD3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUP2"/>
    <dbReference type="Ensembl" id="ENSMODT00000067780.1">
        <property type="protein sequence ID" value="ENSMODP00000051265.1"/>
        <property type="gene ID" value="ENSMODG00000012802.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159051"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012802">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08906">
        <property type="entry name" value="START_STARD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000014">
        <property type="entry name" value="stAR-related lipid transfer protein 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019498">
        <property type="entry name" value="MENTAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000799">
        <property type="entry name" value="StAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029867">
        <property type="entry name" value="STARD3_MLN64_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF2">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10457">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00978">
        <property type="entry name" value="STARPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51439">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="MENTAL" evidence="16">
        <location>
            <begin position="47"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="15">
        <location>
            <begin position="226"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="428" mass="49137" checksum="3D8F7379868E2E8D" modified="2019-12-11" version="1">MTKLPVNSSRDLEQSLPAVASLSTSLPRNQSFSTPFFPPLPEKRKAISDVRRTFCLFVTFDLLFISLLWIIELNTNTSIKKNLEKEIINYNFKTSFFDIFILAFFRFSGLLMGYAVLRLRHWWVIALLSKGAFGYLLPIVSFVIAWLETWFLDFKVLTQEAEEERWYLAAQAAAVRGPLLFPGALSEGQFYSPPESFAGSDIESDDEEAGRKGFSSQDREYIQQGKEAMEVVDQILAQEENWKFEKNNEYGDTVYTLEIPFHGKTFILKAFLQCPAELVYQEVILQPEKMVLWNKMVNACQILHQVEDNTLITYDVSSGTAGGVISPRDFVNVRRIERRRDRYLSSGMATTHFAKPPMHKYIRGENGPGGFIVLKSPNNPRVCTFVWVLNTDLKGRLPRYLIHQNLATTMFEFAFHLRQRVGELCARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUP4</accession>
    <name>A0A5F8GUP4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">KH domain-containing, RNA-binding, signal transduction-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">KHDRBS2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHDRBS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUP4"/>
    <dbReference type="FunCoup" id="A0A5F8GUP4">
        <property type="interactions" value="1611"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000050931"/>
    <dbReference type="Ensembl" id="ENSMODT00000068357.1">
        <property type="protein sequence ID" value="ENSMODP00000050931.1"/>
        <property type="gene ID" value="ENSMODG00000018714.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157134"/>
    <dbReference type="InParanoid" id="A0A5F8GUP4"/>
    <dbReference type="OMA" id="YGHGVNE"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018714">
        <property type="expression patterns" value="Expressed in spinal cord and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032571">
        <property type="entry name" value="Qua1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032335">
        <property type="entry name" value="Sam68-YY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF34">
        <property type="entry name" value="KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16274">
        <property type="entry name" value="Qua1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16568">
        <property type="entry name" value="Sam68-YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="K Homology" evidence="12">
        <location>
            <begin position="58"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="205"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="374" mass="41381" checksum="5E4DE8E5388C65D8" modified="2019-12-11" version="1">MEQEKYLPELMAEKDSLDPSFVHATRLLAEEIEKFQGSEGKKDDEEKKYLDVISNKNIKLSERVLIPVKQYPKRGGSGGSMLSVLASWHGSSYCLGLVFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKTKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEDSSRGRGIRGRGIRVPPTAPSRGRGGAIPPPPPPGRGVPAPRGTTVTRGALPVPPVARGVPTPRARGAPAVPGYRPPPPPAHEAYEEYGYDDGYGGEYDDQSYEAYDSSYATQTQSVPEYYDYGHGTSEDTYDSYAQEEWAPTRSSLKAPPPRAARGGYREHPYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUP5</accession>
    <name>A0A5F8GUP5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin carboxyl-terminal hydrolase 48</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Deubiquitinating enzyme 48</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin thioesterase 48</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquitin-specific-processing protease 48</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">USP48</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with TRAF2 and RELA. Interacts with GPS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUP5"/>
    <dbReference type="Ensembl" id="ENSMODT00000065636.1">
        <property type="protein sequence ID" value="ENSMODP00000051222.1"/>
        <property type="gene ID" value="ENSMODG00000016025.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156015"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016025">
        <property type="expression patterns" value="Expressed in ovary and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02668">
        <property type="entry name" value="Peptidase_C19L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01795">
        <property type="entry name" value="Ubl_USP48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000029">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 48 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033841">
        <property type="entry name" value="Pep_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044743">
        <property type="entry name" value="Ubl_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="19">
        <location>
            <begin position="89"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="20">
        <location>
            <begin position="460"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="613"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="881"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="984" mass="113235" checksum="8B1D60ABC14FCEDF" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUP6</accession>
    <name>A0A5F8GUP6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Post-GPI attachment to proteins 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PGAP2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUP6"/>
    <dbReference type="Ensembl" id="ENSMODT00000087462.1">
        <property type="protein sequence ID" value="ENSMODP00000051358.1"/>
        <property type="gene ID" value="ENSMODG00000008322.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047299"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008322">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 17 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="56" mass="6324" checksum="C4626E2E182CAA65" modified="2019-12-11" version="1">MYQVPLPLERDGILVRLRFTVVAVATVSCPLLAFLFCVVWSLFFNFTETTSTHCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUP8</accession>
    <name>A0A5F8GUP8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SPT3 homolog, SAGA and STAGA complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SUPT3H</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUP8"/>
    <dbReference type="Ensembl" id="ENSMODT00000064641.1">
        <property type="protein sequence ID" value="ENSMODP00000051270.1"/>
        <property type="gene ID" value="ENSMODG00000018921.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010738"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018921">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="388" mass="44299" checksum="043211DF05FD6252" modified="2019-12-11" version="1">MYHVLLNRMYIASCPYFFFSTYILTQEKPMHRDSPTLSALEAWVQWQKKLLHLETASAALDGRVVICAPTRPKHSTVLRCFALSAVEPSYWFLPSFQPKQSSHAGFSLGDARRPLHETAVLVEDIVHTQLINLLQQAAEVSQLRGARVISPEDLLFLMRKDKKKLKRLLKYMFFRDYKSKIVKGIEEDDLLEDKFSSSSNVNKRQKVAQDFLHSIDQTGELLAMFEDDEIDDVKQERMERAERQTRMMDAAQYAEFCESRQLSFSKKASKFRDWLDCSSMEVKPNAIAMEILAYLAYETVAQLVDLALLVRQDMAPKAGDPFSHAISATFIQYHASTESTAACGMEAQSDAIQPSHIREAIRRYGHKIGPVSPFTSAYRRNGMTFLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUP9</accession>
    <name>A0A5F8GUP9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vir like m6A methyltransferase associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">VIRMA</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vir family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUP9"/>
    <dbReference type="Ensembl" id="ENSMODT00000077419.1">
        <property type="protein sequence ID" value="ENSMODP00000050936.1"/>
        <property type="gene ID" value="ENSMODG00000007320.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002833"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007320">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031801">
        <property type="entry name" value="VIR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026736">
        <property type="entry name" value="Virilizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185:SF0">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15912">
        <property type="entry name" value="VIR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Virilizer N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1146" mass="129123" checksum="F00DA6D412BDB0CD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUQ0</accession>
    <name>A0A5F8GUQ0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Odontogenic ameloblast-associated protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Apin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts (via C-terminus) with ARHGEF5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ODAM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUQ0"/>
    <dbReference type="Ensembl" id="ENSMODT00000058947.1">
        <property type="protein sequence ID" value="ENSMODP00000051084.1"/>
        <property type="gene ID" value="ENSMODG00000028253.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011100"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000028253">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031214">
        <property type="term" value="P:biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026802">
        <property type="entry name" value="Odam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16237">
        <property type="entry name" value="ODONTOGENIC AMELOBLAST-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16237:SF3">
        <property type="entry name" value="ODONTOGENIC AMELOBLAST-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15424">
        <property type="entry name" value="ODAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0091">Biomineralization</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023880908" description="Odontogenic ameloblast-associated protein" evidence="15">
        <location>
            <begin position="16"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="254" mass="27823" checksum="B36143C00E38FCA7" modified="2019-12-11" version="1">MRAAILLGFLGVALAAPLLPQPLLSASNSRELLMGLGNARLRGLPPGLQASANPLIFPLPGALHHGPRPLGLSWPSLGHFGGLVPNEVPLPGQARLAQRSQAVQQEAPRLQMLQQNQQDPYQIIPCFFSFGVPQVWGQMVPYYPVCVYGAQDPPLQLSALAGPPQPPEQPIENVLPYTQREMVNLGYPYAGIFMPSYPLKHQTANILASPTDNVVPLELLEEEVKELKVFLMSEIKFLLLLLKRKGSGTYGWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUQ6</accession>
    <name>A0A5F8GUQ6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 883-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC103101823</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUQ6"/>
    <dbReference type="Ensembl" id="ENSMODT00000088585.1">
        <property type="protein sequence ID" value="ENSMODP00000051232.1"/>
        <property type="gene ID" value="ENSMODG00000007565.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161437"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007565">
        <property type="expression patterns" value="Expressed in placenta and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001235">
        <property type="entry name" value="Si:ch211-119o8.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001509">
        <property type="entry name" value="Zinc finger protein 616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002284">
        <property type="entry name" value="Zinc finger protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="588" mass="67084" checksum="AF4B8505253754F6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV00</accession>
    <name>A0A5F8GV00_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHOC2 leucine rich repeat scaffold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SHOC2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV00"/>
    <dbReference type="Ensembl" id="ENSMODT00000053346.1">
        <property type="protein sequence ID" value="ENSMODP00000051327.1"/>
        <property type="gene ID" value="ENSMODG00000010356.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156270"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010356">
        <property type="expression patterns" value="Expressed in spermatid and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000327">
        <property type="entry name" value="leucine-rich repeat protein SHOC-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000407">
        <property type="entry name" value="leucine-rich repeat protein SHOC-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF33">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="397"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="536" mass="59692" checksum="0CEF8BD8233F75BA" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV01</accession>
    <name>A0A5F8GV01_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homolog subfamily C member 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DNAJC10</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV01"/>
    <dbReference type="Ensembl" id="ENSMODT00000084682.1">
        <property type="protein sequence ID" value="ENSMODP00000051370.1"/>
        <property type="gene ID" value="ENSMODG00000010507.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155558"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010507">
        <property type="expression patterns" value="Expressed in uterus and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03004">
        <property type="entry name" value="PDI_a_ERdj5_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd03003">
        <property type="entry name" value="PDI_a_ERdj5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000029">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000087">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000106">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000125">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000135">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000169">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052460">
        <property type="entry name" value="ER_disulfide_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035674">
        <property type="entry name" value="ERdj5_TRX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035673">
        <property type="entry name" value="ERdj5_TRX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44340">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44340:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="115"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="413"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="601"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="741"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="773" mass="90018" checksum="6051414141618A93" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV04</accession>
    <name>A0A5F8GV04_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">TP53-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TP53BP1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV04"/>
    <dbReference type="Ensembl" id="ENSMODT00000086495.1">
        <property type="protein sequence ID" value="ENSMODP00000051458.1"/>
        <property type="gene ID" value="ENSMODG00000017806.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011891"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017806">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140005">
        <property type="term" value="F:histone H4K20me2 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045830">
        <property type="term" value="P:positive regulation of isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20383">
        <property type="entry name" value="Tudor_53BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000021">
        <property type="entry name" value="Tumor suppressor p53-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000019">
        <property type="entry name" value="Tumor suppressor p53-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000003">
        <property type="entry name" value="Tumor suppressor p53-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015125">
        <property type="entry name" value="53-BP1_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09038">
        <property type="entry name" value="53-BP1_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18428">
        <property type="entry name" value="BRCT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0010">Activator</keyword>
    <keyword evidence="17" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="544"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="87"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="441"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="566"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="741" mass="80505" checksum="86DFDB691C0B36B5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV07</accession>
    <name>A0A5F8GV07_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Piwi like RNA-mediated gene silencing 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV07"/>
    <dbReference type="Ensembl" id="ENSMODT00000069736.1">
        <property type="protein sequence ID" value="ENSMODP00000051199.1"/>
        <property type="gene ID" value="ENSMODG00000045138.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183200"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000045138">
        <property type="expression patterns" value="Expressed in testis and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000014">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000003">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="12">
        <location>
            <begin position="490"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="13">
        <location>
            <begin position="763"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114539" checksum="588A57FA0BA3F4DE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV10</accession>
    <name>A0A5F8GV10_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myotubularin-related protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inactive phosphatidylinositol 3-phosphatase 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MTMR12</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer with lipid phosphatase MTM1. Heterodimer with lipid phosphatase MTMR2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Sarcoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV10"/>
    <dbReference type="Ensembl" id="ENSMODT00000052053.1">
        <property type="protein sequence ID" value="ENSMODP00000051463.1"/>
        <property type="gene ID" value="ENSMODG00000020416.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160263"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020416">
        <property type="expression patterns" value="Expressed in spermatid and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd14594">
        <property type="entry name" value="PTP-MTMR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000188">
        <property type="entry name" value="Myotubularin related protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022587">
        <property type="entry name" value="MTMR12-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030576">
        <property type="entry name" value="MTMR12_PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF37">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12578">
        <property type="entry name" value="3-PAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="10">
        <location>
            <begin position="203"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="689" mass="79104" checksum="689BF0ECB8FB7305" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV12</accession>
    <name>A0A5F8GV12_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cordon-bleu WH2 repeat protein like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COBLL1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV12"/>
    <dbReference type="Ensembl" id="ENSMODT00000076223.1">
        <property type="protein sequence ID" value="ENSMODP00000051051.1"/>
        <property type="gene ID" value="ENSMODG00000005782.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063608"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005782">
        <property type="expression patterns" value="Expressed in kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000065">
        <property type="entry name" value="Cordon-bleu WH2 repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039895">
        <property type="entry name" value="COBL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019025">
        <property type="entry name" value="Cordon-bleu_ubiquitin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21557">
        <property type="entry name" value="CORDON-BLEU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21557:SF2">
        <property type="entry name" value="CORDON-BLEU PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09469">
        <property type="entry name" value="Cobl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cordon-bleu ubiquitin-like" evidence="3">
        <location>
            <begin position="145"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="937"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1043"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1098" mass="122406" checksum="1233D53A077262DB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV15</accession>
    <name>A0A5F8GV15_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sortilin related VPS10 domain containing receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SORCS1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS10-related sortilin family. SORCS subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV15"/>
    <dbReference type="Ensembl" id="ENSMODT00000074203.1">
        <property type="protein sequence ID" value="ENSMODP00000051209.1"/>
        <property type="gene ID" value="ENSMODG00000010737.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234563"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010737">
        <property type="expression patterns" value="Expressed in spinal cord and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000001">
        <property type="entry name" value="Sortilin related VPS10 domain containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000083">
        <property type="entry name" value="Sortilin-related VPS10 domain containing receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000001">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF8">
        <property type="entry name" value="VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="860"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="11">
        <location>
            <begin position="594"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="887"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="926" mass="104133" checksum="7DE0914D711D3C1E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV16</accession>
    <name>A0A5F8GV16_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CARS1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Cys) + L-cysteine + ATP = L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:17774"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV16"/>
    <dbReference type="Ensembl" id="ENSMODT00000062471.1">
        <property type="protein sequence ID" value="ENSMODP00000051468.1"/>
        <property type="gene ID" value="ENSMODG00000007058.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006347"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007058">
        <property type="expression patterns" value="Expressed in placenta and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10310">
        <property type="entry name" value="GST_C_CysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="15">
        <location>
            <begin position="118"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="694"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="694"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="791" mass="89302" checksum="FE311747E074329D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV18</accession>
    <name>A0A5F8GV18_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZC3H14</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation. Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer; facilitating circular RNAs (circRNAs) formation. Associates with the spliceosome. Interacts with HOOK2. Interacts with ZFC3H1 in a RNase-sensitive manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV18"/>
    <dbReference type="Ensembl" id="ENSMODT00000084800.1">
        <property type="protein sequence ID" value="ENSMODP00000051342.1"/>
        <property type="gene ID" value="ENSMODG00000003282.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000038430"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003282">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000001">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000006">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 14 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000003">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 14 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="685" mass="77098" checksum="BD13A680FDA0472E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV20</accession>
    <name>A0A5F8GV20_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Unconventional myosin-Ia</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Brush border myosin I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Myosin I heavy chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MYO1A</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV20"/>
    <dbReference type="Ensembl" id="ENSMODT00000060497.1">
        <property type="protein sequence ID" value="ENSMODP00000051214.1"/>
        <property type="gene ID" value="ENSMODG00000019400.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160660"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019400">
        <property type="expression patterns" value="Expressed in testis and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF291">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="15"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="355"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="14">
        <location>
            <begin position="603"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="781" mass="87844" checksum="3F99B24121B19E10" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV21</accession>
    <name>A0A5F8GV21_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">THAP domain containing 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:63117"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV21"/>
    <dbReference type="Ensembl" id="ENSMODT00000063180.1">
        <property type="protein sequence ID" value="ENSMODP00000051061.1"/>
        <property type="gene ID" value="ENSMODG00000016079.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158447"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016079">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF4">
        <property type="entry name" value="PEROXYNITRITE ISOMERASE THAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4-like heme-binding" evidence="3">
        <location>
            <begin position="19"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00036993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="180" mass="19775" checksum="F94E746C61AECF64" modified="2019-12-11" version="1">MLSGGQSPGPETPKMSPLIEPLSWMLGTWLSEPPGHGVYPSLQPFHYLEEVHISHVGQPMLNFSFNAFHPDTKKPMHRECGFIRLKPDSNKVAFVSAQNTGIVEMEEGEVNGQELCITSHSIARMSLAAEPPVEQVKPPRGLPVPEPAREWGTTEGSLVTSRRSPSYQWANGPPCAVCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV23</accession>
    <name>A0A5F8GV23_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Partitioning defective 3 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Atypical PKC isotype-specific-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">PARD3</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="21">Interacts with PRKCZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PAR3 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000066322.1">
        <property type="protein sequence ID" value="ENSMODP00000051347.1"/>
        <property type="gene ID" value="ENSMODG00000007069.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022889"/>
    <dbReference type="CTD" id="56288"/>
    <dbReference type="GeneTree" id="ENSGT00950000183214"/>
    <dbReference type="OrthoDB" id="6264899at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007069">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06691">
        <property type="entry name" value="PDZ1_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23058">
        <property type="entry name" value="PDZ2_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23059">
        <property type="entry name" value="PDZ3_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000078">
        <property type="entry name" value="Partitioning defective 3 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000011">
        <property type="entry name" value="partitioning defective 3 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000040">
        <property type="entry name" value="partitioning defective 3 homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000017">
        <property type="entry name" value="partitioning defective 3 homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021922">
        <property type="entry name" value="Par3/HAL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF10">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12053">
        <property type="entry name" value="Par3_HAL_N_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="20" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="14" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0221">Differentiation</keyword>
    <keyword evidence="17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="271"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="461"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="590"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="156"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="412"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="818"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="909"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1039"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="412"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="921"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="950"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="966"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1039"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1079"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1121"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1135"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1168"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1181"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1206"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1270"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1322"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1332"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00065272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00070151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1341" mass="149903" checksum="7E6A083E9AF770C3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV24</accession>
    <name>A0A5F8GV24_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="11">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FES</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 24">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer. Interacts with BCR. Interacts (when activated, via coiled coil domain) with TRIM28. Interacts (via SH2 domain) with phosphorylated EZR, MS4A2/FCER1B and HCLS1/HS1. Interacts with phosphorylated KIT. Interacts with FLT3. Interacts (via F-BAR domain) with soluble tubulin. Interacts (via SH2 domain) with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV24"/>
    <dbReference type="Ensembl" id="ENSMODT00000083701.1">
        <property type="protein sequence ID" value="ENSMODP00000051395.1"/>
        <property type="gene ID" value="ENSMODG00000019456.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158881"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019456">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000006">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000212">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000089">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000020">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016250">
        <property type="entry name" value="Tyr-prot_kinase_Fes/Fps"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000632">
        <property type="entry name" value="TyrPK_fps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="F-BAR" evidence="21">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="19">
        <location>
            <begin position="402"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="503"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="509"/>
            <end position="517"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 16">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000632-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000632-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="764" mass="86784" checksum="F0996A5094DE5D0F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV25</accession>
    <name>A0A5F8GV25_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Parkin coregulated like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PACRGL</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV25"/>
    <dbReference type="Ensembl" id="ENSMODT00000026387.2">
        <property type="protein sequence ID" value="ENSMODP00000051219.1"/>
        <property type="gene ID" value="ENSMODG00000000641.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159756"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000641">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="88" mass="9923" checksum="E37D1392AFEA4112" modified="2019-12-11" version="1">RMQKSESHGSLQMRNRVTGNYEQRISSGSQEKHRSVVHQNKLLPSKNSPDSVRKPHPRPSDKLNPKTIDPGSLMIIKAKIPTYCSICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV27</accession>
    <name>A0A5F8GV27_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat and EF-hand domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ANKEF1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV27"/>
    <dbReference type="Ensembl" id="ENSMODT00000071937.1">
        <property type="protein sequence ID" value="ENSMODP00000051066.1"/>
        <property type="gene ID" value="ENSMODG00000004764.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156852"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004764">
        <property type="expression patterns" value="Expressed in testis and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052801">
        <property type="entry name" value="Ankyrin-EF-hand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24127">
        <property type="entry name" value="ANKYRIN REPEAT AND EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24127:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="547"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="733" mass="82386" checksum="474EF1DD4A2E985D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV28</accession>
    <name>A0A5F8GV28_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">E3 ubiquitin-protein ligase TRIM9</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">RING-type E3 ubiquitin transferase TRIM9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Tripartite motif-containing protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">TRIM9</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with SNAP25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV28"/>
    <dbReference type="Ensembl" id="ENSMODT00000057569.1">
        <property type="protein sequence ID" value="ENSMODP00000051352.1"/>
        <property type="gene ID" value="ENSMODG00000013160.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154071"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013160">
        <property type="expression patterns" value="Expressed in cerebellum and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19843">
        <property type="entry name" value="Bbox1_TRIM9_C-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19826">
        <property type="entry name" value="Bbox2_TRIM9_C-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16755">
        <property type="entry name" value="RING-HC_TRIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12889">
        <property type="entry name" value="SPRY_PRY_TRIM67_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000009">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000178">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000168">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.40:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000329">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000017">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase TRIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049582">
        <property type="entry name" value="TRIM9_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0770">Synapse</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="26">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="27">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="27">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="COS" evidence="30">
        <location>
            <begin position="374"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="29">
        <location>
            <begin position="440"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="28">
        <location>
            <begin position="595"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="799" mass="89542" checksum="73B011AD97771399" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV29</accession>
    <name>A0A5F8GV29_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protocadherin-15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PCDH15</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000074229.1">
        <property type="protein sequence ID" value="ENSMODP00000051224.1"/>
        <property type="gene ID" value="ENSMODG00000016351.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156675"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016351">
        <property type="expression patterns" value="Expressed in spinal cord and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050957">
        <property type="term" value="P:equilibrioception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048839">
        <property type="term" value="P:inner ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050953">
        <property type="term" value="P:sensory perception of light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3430:FF:000001">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000047">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000048">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000049">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000050">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000054">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000055">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000056">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000057">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000063">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041149">
        <property type="entry name" value="EC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030718">
        <property type="entry name" value="EC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056989">
        <property type="entry name" value="PCDH15_12th_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF49">
        <property type="entry name" value="PROTOCADHERIN FAT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18432">
        <property type="entry name" value="ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23206">
        <property type="entry name" value="PCDH15_12th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023903877" description="Protocadherin-15" evidence="15">
        <location>
            <begin position="25"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1339"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="135"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="265"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="383"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="504"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="682"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="783"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="890"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1000"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1108"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1380"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1494"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1383"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1508"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1532"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1542"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1593"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1626"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1696"/>
            <end position="1712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1724" mass="189947" checksum="9DCB178C0CC8A3D4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6N4</accession>
    <name>A0A5F8H6N4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative methyltransferase DDB_G0268948</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC100025184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007486209.1">
        <property type="nucleotide sequence ID" value="XM_007486147.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6N4"/>
    <dbReference type="Ensembl" id="ENSMODT00000066896.1">
        <property type="protein sequence ID" value="ENSMODP00000055645.1"/>
        <property type="gene ID" value="ENSMODG00000050747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100025184"/>
    <dbReference type="KEGG" id="mdo:100025184"/>
    <dbReference type="GeneTree" id="ENSGT00940000163794"/>
    <dbReference type="OMA" id="FSAVHWF"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000050747">
        <property type="expression patterns" value="Expressed in liver and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000370">
        <property type="entry name" value="Si:ch211-93g23.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="90"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="322" mass="35932" checksum="2C84EB161D6CB711" modified="2019-12-11" version="1">MQGCKASCPPPGRNQAREIPGQNSHSLAQGFQLLKEEREDQPAIMSAHLFEGKDHAAIYRKHRFPPPDELLSIIFSFLEEKKGKPYDLAVDVGCGSGQSTQVLGPHFARVLGTDISEAQIQQAQQAQNQANVSYRVCPAENLPVEDASVDLLTAFTAAHWFDLKAFMRELERVLKPGGCVSLSSYIPSIRIHYGDCSAELNAIFQETQTVLNKYANEKVSIVRSEYQEIFDLVPFPDKKRTLFHSKEVSFTVASLMGFMQSFSMFQTFHNAQPEAAKALLHQTQERFLKTMKVSSPETELGISFKYVCVLACKAPTKEKVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6N5</accession>
    <name>A0A5F8H6N5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PDE6A</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6N5"/>
    <dbReference type="Ensembl" id="ENSMODT00000072729.1">
        <property type="protein sequence ID" value="ENSMODP00000055447.1"/>
        <property type="gene ID" value="ENSMODG00000009879.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161330"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009879">
        <property type="expression patterns" value="Expressed in uterus and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000001">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0140">cGMP</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="7">
        <location>
            <begin position="402"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="683"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="714" mass="83239" checksum="E66E8B9BE6A51032" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6N6</accession>
    <name>A0A5F8H6N6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Proliferation-associated SNF2-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6N6"/>
    <dbReference type="Ensembl" id="ENSMODT00000056135.1">
        <property type="protein sequence ID" value="ENSMODP00000055224.1"/>
        <property type="gene ID" value="ENSMODG00000005589.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156410"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005589">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18009">
        <property type="entry name" value="DEXHc_HELLS_SMARCA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000577">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044753">
        <property type="entry name" value="HELLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="83"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="453"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="688" mass="79659" checksum="73FDE16EDA6942BA" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6P0</accession>
    <name>A0A5F8H6P0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MTSS I-BAR domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MTSS1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MTSS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6P0"/>
    <dbReference type="Ensembl" id="ENSMODT00000066106.1">
        <property type="protein sequence ID" value="ENSMODP00000055452.1"/>
        <property type="gene ID" value="ENSMODG00000001828.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183156"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001828">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07643">
        <property type="entry name" value="I-BAR_IMD_MIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22060">
        <property type="entry name" value="WH2_MTSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000010">
        <property type="entry name" value="Metastasis suppressor 1, isoform CRA_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030127">
        <property type="entry name" value="MTSS1/MTSS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708">
        <property type="entry name" value="ACTIN BUNDLING/MISSING IN METASTASIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708:SF10">
        <property type="entry name" value="PROTEIN MTSS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMD" evidence="9">
        <location>
            <begin position="16"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="8">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="732" mass="79247" checksum="4B45D55054EBCE87" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6P2</accession>
    <name>A0A5F8H6P2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450 4B1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CYP4B1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6P2"/>
    <dbReference type="Ensembl" id="ENSMODT00000056355.1">
        <property type="protein sequence ID" value="ENSMODP00000055457.1"/>
        <property type="gene ID" value="ENSMODG00000001709.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161441"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001709">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20678">
        <property type="entry name" value="CYP4B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000005">
        <property type="entry name" value="cytochrome P450 4F22 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF149">
        <property type="entry name" value="CYTOCHROME P450 4B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="521" mass="60539" checksum="940BDACE4BB64526" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6P3</accession>
    <name>A0A5F8H6P3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC1 domain family member 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TBC1D32</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6P3"/>
    <dbReference type="Ensembl" id="ENSMODT00000071659.1">
        <property type="protein sequence ID" value="ENSMODP00000054896.1"/>
        <property type="gene ID" value="ENSMODG00000017766.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153528"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017766">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055392">
        <property type="entry name" value="BROMI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032735">
        <property type="entry name" value="BROMI_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055391">
        <property type="entry name" value="BROMI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF3">
        <property type="entry name" value="PROTEIN BROAD-MINDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14961">
        <property type="entry name" value="BROMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23440">
        <property type="entry name" value="BROMI_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23431">
        <property type="entry name" value="BROMI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BROMI N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="BROMI middle region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="BROMI C-terminal Rab TBC-like" evidence="3">
        <location>
            <begin position="862"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="BROMI C-terminal Rab TBC-like" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1235" mass="141047" checksum="9160F63E5E67BB83" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6P4</accession>
    <name>A0A5F8H6P4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxynucleotidyltransferase terminal interacting protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6P4"/>
    <dbReference type="Ensembl" id="ENSMODT00000074047.1">
        <property type="protein sequence ID" value="ENSMODP00000055229.1"/>
        <property type="gene ID" value="ENSMODG00000004761.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048142"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004761">
        <property type="expression patterns" value="Expressed in blood and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="5">
        <location>
            <begin position="607"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="508"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="726" mass="82144" checksum="A9D0C5E8A591B160" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6P5</accession>
    <name>A0A5F8H6P5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Solute carrier family 16 member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SLC16A8</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6P5"/>
    <dbReference type="Ensembl" id="ENSMODT00000086207.1">
        <property type="protein sequence ID" value="ENSMODP00000055660.1"/>
        <property type="gene ID" value="ENSMODG00000049590.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161934"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000049590">
        <property type="expression patterns" value="Expressed in blood and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000667">
        <property type="entry name" value="monocarboxylate transporter 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF26">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="481" mass="50799" checksum="CEB492E69B17CC0D" modified="2019-12-11" version="1">MGTNPGFLSFVLVPIWKEVARSPPGRPGPAPDGGWGWVVLLSCFVVTGFSYAFPKAVSVYFKALMRDFHVGYSDTAWISSIMLAMLYGTGPVSSILVNQFGCRPVMLAGGLLASSGMILASFTTSLVQLYLTAGAWAWLSLQPLLIMLGLYFDRRRPLANGLAAAGSPVFLSHFGWRGGFLLMGGLLLNCCTCGAVMRPLAGGPGRRRLLDLSVFTERGFVVYAIAKFILVLGLFVPTIMLVNYAKDAGVPDAEAAFLLSVIGFVDIVARPACGALAGLSRVRPHVAYLFSLAMLANGLTDLCSARARSYRALVGFCVAFGLSYGMVGALQFEVLMATVGARRFPSAIGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVLLSALFLSTATYCCLRKPRGPGLASDPHPGARDTEAENDGDLGPPAAAIAAAQNSENHVAPEAEQSEGKEDEEGEEERKPVLGGSVETLGKGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6P6</accession>
    <name>A0A5F8H6P6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Thrombospondin type-1 domain-containing protein 7A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">THSD7B</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in actin cytoskeleton rearrangement.</text>
    </comment>
    <comment type="function">
        <text evidence="15">The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000082068.1">
        <property type="protein sequence ID" value="ENSMODP00000055608.1"/>
        <property type="gene ID" value="ENSMODG00000001131.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159262"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001131">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000014">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000017">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000018">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000020">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000031">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000050">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000063">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000015">
        <property type="entry name" value="Thrombospondin, type I, domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056991">
        <property type="entry name" value="TSP1_TSH7A-B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF7">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23308">
        <property type="entry name" value="TSP1_TSH7A-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1519"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="320"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="583"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="719"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="983"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="1237"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="1359"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="domain" description="Thrombospondin type-1" evidence="19">
        <location>
            <begin position="1450"/>
            <end position="1477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF23308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1579" mass="177397" checksum="BA3F102F53C4E392" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6P7</accession>
    <name>A0A5F8H6P7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DDB1- and CUL4-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">IQ motif and WD repeat-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nuclear receptor interaction protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DCAF6</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A and CUL4B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007480784.1">
        <property type="nucleotide sequence ID" value="XM_007480722.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6P7"/>
    <dbReference type="Ensembl" id="ENSMODT00000080414.1">
        <property type="protein sequence ID" value="ENSMODP00000055462.1"/>
        <property type="gene ID" value="ENSMODG00000002855.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013868"/>
    <dbReference type="CTD" id="55827"/>
    <dbReference type="GeneTree" id="ENSGT00950000182900"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002855">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000078">
        <property type="entry name" value="DDB1- and CUL4-associated factor 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000045">
        <property type="entry name" value="DDB1- and CUL4-associated factor 6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF39">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="287"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="355"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="496"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="505"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="954" mass="106023" checksum="BDE53FC29FEAEC50" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6P8</accession>
    <name>A0A5F8H6P8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6P8"/>
    <dbReference type="Ensembl" id="ENSMODT00000081975.1">
        <property type="protein sequence ID" value="ENSMODP00000054901.1"/>
        <property type="gene ID" value="ENSMODG00000045422.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286907"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000045422">
        <property type="expression patterns" value="Expressed in blood and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051036">
        <property type="entry name" value="SIGLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035">
        <property type="entry name" value="SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035:SF125">
        <property type="entry name" value="SIALIC ACID-BINDING IG-LIKE LECTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023860992" description="Ig-like domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="134"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="293" mass="31951" checksum="32F0953AA15027BD" modified="2019-12-11" version="1">RGWLFFLYIFLLKGLCLPSGSLSQVLQVPPSVTVQEGLCAQVLCTFYPRYSIDKSYPAYGSWFREGTNTDTGKPVATNAPGRQVERGAQGRFRLLGDPQRNNCSLSISDARATDSGRYFFRFEQGETKYNIYHPQLSVSLSQKPDISVPEVLEAGTPVTLNCTFPSACWDNSTYRFSWSGAALPSPHDGSGPSPSSEVSFTPGLQHHGTPVTCQVTLPGGRLTAQRTIFLNVSCECWARSLLGPREGWSSWLCWWGLHGGLGMAGAWLSPSLSGSRSQHRAGPRGGRNHAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6P9</accession>
    <name>A0A5F8H6P9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MAM domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MAMDC4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6P9"/>
    <dbReference type="Ensembl" id="ENSMODT00000071244.1">
        <property type="protein sequence ID" value="ENSMODP00000055234.1"/>
        <property type="gene ID" value="ENSMODG00000017335.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162046"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017335">
        <property type="expression patterns" value="Expressed in placenta and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF129">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1127"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="64"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="247"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="452"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="629"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="787"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="947"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1207" mass="133691" checksum="86F24A1DF70C49B0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Q5</accession>
    <name>A0A5F8H6Q5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glutamate metabotropic receptor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GRM8</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Q5"/>
    <dbReference type="Ensembl" id="ENSMODT00000079676.1">
        <property type="protein sequence ID" value="ENSMODP00000055665.1"/>
        <property type="gene ID" value="ENSMODG00000015246.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234648"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015246">
        <property type="expression patterns" value="Expressed in spinal cord and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000009">
        <property type="entry name" value="Glutamate receptor, metabotropic 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000176">
        <property type="entry name" value="metabotropic glutamate receptor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000144">
        <property type="entry name" value="GPCR_3_mGluR8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01058">
        <property type="entry name" value="MTABOTROPC8R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="13">
        <location>
            <begin position="33"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="GPCR family 3 nine cysteines" evidence="14">
        <location>
            <begin position="301"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="365" mass="41633" checksum="DF9A46497E03039F" modified="2019-12-11" version="1">LIYDLFIEGWKLISKFKEGFSLPSFLSFPFAGGVCIAQSQKIPREPRPGEFDKIIKRLLETPNARAVIMFANEDDIRRILEAAKKINQSGHFLWIGSDSWGSKISPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLSYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLNVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELTCELCPLDQRPNNSPLAQCRSTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Q7</accession>
    <name>A0A5F8H6Q7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RasGEF domain family member 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RASGEF1A</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007478550.1">
        <property type="nucleotide sequence ID" value="XM_007478488.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Q7"/>
    <dbReference type="Ensembl" id="ENSMODT00000067312.1">
        <property type="protein sequence ID" value="ENSMODP00000055472.1"/>
        <property type="gene ID" value="ENSMODG00000001262.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100012312"/>
    <dbReference type="CTD" id="221002"/>
    <dbReference type="GeneTree" id="ENSGT00940000160822"/>
    <dbReference type="OrthoDB" id="20825at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001262">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000008">
        <property type="entry name" value="Ras-GEF domain-containing family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.870.10:FF:000007">
        <property type="entry name" value="Ras-GEF domain-containing family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF172">
        <property type="entry name" value="RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="34"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="207"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="474" mass="54668" checksum="361C81196EF85861" modified="2019-12-11" version="1">MPQTPIFSSMLGSSCSGQVQPDMGERSGGDLVFQDGNLISGSLEALIEHLVPTVDYYPDRTYIFTFLLSSRIFIPPYDLLAKVGQICTKQKQQLEAETEKAKLKSFTAKIIQLLKEWTEAFPYDFQDEKVMKELKEITHKITQCDEENGTVKTTITQMTQNLILSLTTRNQFQEIREKFRQPVTDKGTILKSKPQAAQKDILSVCCDPLILAQQLTHIELERVSNIYPEDLMQIVSHMDSLDNHKCRGDVTKTYTLEAYDNWFNCLSMLVATEICRVVKKKQRTRMVEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGAAQRSQTANSSREKIVIPVFNLFIKDIYFLHKIHTNRLPNGQINFKKFWEISRQIHDFLTWKQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLLNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Q8</accession>
    <name>A0A5F8H6Q8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PDE8B</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Q8"/>
    <dbReference type="Ensembl" id="ENSMODT00000062843.1">
        <property type="protein sequence ID" value="ENSMODP00000055623.1"/>
        <property type="gene ID" value="ENSMODG00000019740.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157817"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019740">
        <property type="expression patterns" value="Expressed in endometrium and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000002">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057304">
        <property type="entry name" value="PDE8-like_REC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08629">
        <property type="entry name" value="PDE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23198">
        <property type="entry name" value="PDE8A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="11">
        <location>
            <begin position="438"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="514"/>
            <end position="518"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="782" mass="87463" checksum="D26B226392220375" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H700</accession>
    <name>A0A5F8H700_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylhydrolase ARH1</fullName>
            <ecNumber evidence="4">3.2.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ADP-ribose-L-arginine cleaving enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylarginine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ADPRH</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.19" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H700"/>
    <dbReference type="Ensembl" id="ENSMODT00000084098.1">
        <property type="protein sequence ID" value="ENSMODP00000055329.1"/>
        <property type="gene ID" value="ENSMODG00000043232.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063627"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000043232">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003875">
        <property type="term" value="F:ADP-ribosylarginine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051725">
        <property type="term" value="P:protein de-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4080.10:FF:000002">
        <property type="entry name" value="ADP-ribosylarginine hydrolase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012108">
        <property type="entry name" value="ADP-ribosylarg_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF26">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016939">
        <property type="entry name" value="ADP_ribslarg_hdr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="387" mass="43145" checksum="FEA51226EF177A97" modified="2019-12-11" version="1">MLTRKSLVFFLRQKISPKKTHHLGHIMSTGLLERYVAAMVLSAVGDSLGYFNRKWEFLLNGELIHQQLAKLGGLDAINIEGWRVSDDTVMHLATAEALITAGKEEDLTRVYSLIARHYKECMDDMDGRAPGTASVSNALKLEPDEPNGWRIPFNKHEGGCGAAMRAMCIGLRFPHPEQQDTLIQVSIESGRMTHHHPTGYLGAVASALFTAYAVNGKPPQEWGKGLMEVLPKAKNYIVQAGYYVKENLESWDYFQDQWEKYLKLRGISNGGPPTFPELFGVKERDEFYKSVSYSGWGGSSGHDAPLIAYDAILAAEDSWKELAHRAFFHGGDSDSTAAIAGCWWGVMHGFKGVSPSNYKRLEYKDRLEKAARALYALQSKESSVITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H702</accession>
    <name>A0A5F8H702_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Y-box binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">YBX2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H702"/>
    <dbReference type="Ensembl" id="ENSMODT00000067395.1">
        <property type="protein sequence ID" value="ENSMODP00000055001.1"/>
        <property type="gene ID" value="ENSMODG00000017596.6"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159816"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017596">
        <property type="expression patterns" value="Expressed in testis and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023894035" evidence="2">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="272" mass="30227" checksum="F4281D5738942197" modified="2019-12-11" version="1">SPALFSLLDLLPLAATQVLGTVKWFNVRNGYGFINRYLSSSHCFFPNQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKSAEAANVTGPGEIPVKGSRYAPNRRRFRRFIPRPRPAAPPPLVAEAPTGVAEPGSEGERAEDPSQRPRRRRPPPFFYRRRFVRGPRPSNQQQPMEGTDGVEPKDPAPLEGDQQQGDERYTLPPPPFLQPTTEGGDGETKPSQGPTDGSRPEPQRPRNRPYFQRRRQQPPGPRQSSAPETSTPITSGDSPTTLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H705</accession>
    <name>A0A5F8H705_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leukocyte surface antigen CD47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Integrin-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CD47</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H705"/>
    <dbReference type="Ensembl" id="ENSMODT00000080818.1">
        <property type="protein sequence ID" value="ENSMODP00000055334.1"/>
        <property type="gene ID" value="ENSMODG00000018045.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007697"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018045">
        <property type="expression patterns" value="Expressed in uterine wall and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070053">
        <property type="term" value="F:thrombospondin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022409">
        <property type="term" value="P:positive regulation of cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002684">
        <property type="term" value="P:positive regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050729">
        <property type="term" value="P:positive regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050766">
        <property type="term" value="P:positive regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16090">
        <property type="entry name" value="IgV_CD47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000521">
        <property type="entry name" value="leukocyte surface antigen CD47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006704">
        <property type="entry name" value="CD47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013147">
        <property type="entry name" value="CD47-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013270">
        <property type="entry name" value="CD47_Vset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037805">
        <property type="entry name" value="IgV_CD47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10613">
        <property type="entry name" value="LEUKOCYTE SURFACE ANTIGEN CD47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10613:SF0">
        <property type="entry name" value="LEUKOCYTE SURFACE ANTIGEN CD47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04549">
        <property type="entry name" value="CD47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08204">
        <property type="entry name" value="V-set_CD47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023809010" description="Leukocyte surface antigen CD47" evidence="17">
        <location>
            <begin position="19"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="362" mass="39327" checksum="41479AB1661E1E6F" modified="2019-12-11" version="1">MWPLVAVLLLGTVCGGSAQLTFNSTRIVEKTICNETVILPCIVSNLELRKLKAMYVKWKHKGKEIFTFDGVDNKFNSSDDFKSATIAFSHLTEGNASLQLKASDAVPGNYTCEVTESNREGEIIVELRYHMECIYTPGAKIHESGSRGSESSDLGKPFLTDHKLNAPRTTKFKLNNRTDPGNPPPGSGSKVSWFHPKENILIVIFPILAILLFWGQFGIVTLKYKSNCTSEKTIGLIIAGLFLTVVVIVGAVLFVPGEYSVKNASGLGLIVIPTVTLVVLQYCLFTTAFGMTLFAIGILILQFLGYILAVIGLSLCITECSPTQGPLMISGLGIIALAELLGLVYMKFVASNQKTIPPSRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H706</accession>
    <name>A0A5F8H706_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Dynein axonemal heavy chain 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">DNAH11</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000078006.1">
        <property type="protein sequence ID" value="ENSMODP00000055770.1"/>
        <property type="gene ID" value="ENSMODG00000001356.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158880"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001356">
        <property type="expression patterns" value="Expressed in lung and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000008">
        <property type="entry name" value="Dynein axonemal heavy chain 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000667">
        <property type="entry name" value="Dynein axonemal heavy chain 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000219">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000002">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000411">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000001">
        <property type="entry name" value="Dynein, axonemal, heavy chain 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF12">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="16">
        <location>
            <begin position="69"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain tail" evidence="16">
        <location>
            <begin position="404"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="17">
        <location>
            <begin position="1098"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="18">
        <location>
            <begin position="1637"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="22">
        <location>
            <begin position="2120"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="23">
        <location>
            <begin position="2456"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="20">
        <location>
            <begin position="2584"/>
            <end position="2839"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="19">
        <location>
            <begin position="2919"/>
            <end position="3199"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="21">
        <location>
            <begin position="3226"/>
            <end position="3443"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="15">
        <location>
            <begin position="3653"/>
            <end position="3773"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="24">
        <location>
            <begin position="3805"/>
            <end position="3941"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="25">
        <location>
            <begin position="3949"/>
            <end position="4242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3078"/>
            <end position="3147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="4244" mass="486500" checksum="C09C7BC78D121B56" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H707</accession>
    <name>A0A5F8H707_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Voltage-dependent R-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">CACNA1E</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000083454.1">
        <property type="protein sequence ID" value="ENSMODP00000055006.1"/>
        <property type="gene ID" value="ENSMODG00000006729.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155601"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006729">
        <property type="expression patterns" value="Expressed in cerebellum and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000011">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000013">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000015">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000023">
        <property type="entry name" value="Voltage-dependent R-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000025">
        <property type="entry name" value="Voltage-dependent R-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005449">
        <property type="entry name" value="VDCC_R_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF5">
        <property type="entry name" value="VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01633">
        <property type="entry name" value="RVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="828"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1001"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1082"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1112"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1141"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1206"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1299"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="1339"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1594"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1597"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1670"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="972"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1776" mass="202154" checksum="8CB2323181407D0B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H708</accession>
    <name>A0A5F8H708_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Caspase recruitment domain-containing protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CARD-containing MAGUK protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CARD11</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Homodimer; disulfide-linked. Homomultimer; polymerizes following activation, forming a nucleating helical template that seeds BCL10-filament formation via a CARD-CARD interaction. Interacts (via CARD domain) with BCL10 (via CARD domain); interaction takes place following CARD11 activation and polymerization, leading to the formation of a filamentous CBM complex assembly. Component of a CBM complex (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane raft</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H708"/>
    <dbReference type="Ensembl" id="ENSMODT00000084055.1">
        <property type="protein sequence ID" value="ENSMODP00000055728.1"/>
        <property type="gene ID" value="ENSMODG00000000213.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158573"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000213">
        <property type="expression patterns" value="Expressed in blood and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032743">
        <property type="term" value="P:positive regulation of interleukin-2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050870">
        <property type="term" value="P:positive regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050862">
        <property type="term" value="P:positive regulation of T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08808">
        <property type="entry name" value="CARD_CARD11_CARMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06736">
        <property type="entry name" value="PDZ_CARD11_CARD14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000148">
        <property type="entry name" value="Caspase recruitment domain family member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000136">
        <property type="entry name" value="Caspase recruitment domain family member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000003">
        <property type="entry name" value="Caspase recruitment domain family, member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000770">
        <property type="entry name" value="Caspase recruitment domain family, member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042141">
        <property type="entry name" value="CARD_CARD11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14559">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14559:SF4">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="16">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="668"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="453"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="159"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1142" mass="132633" checksum="3995246330E53BDD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H709</accession>
    <name>A0A5F8H709_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spermidine/spermine N1-acetyltransferase family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SAT2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H709"/>
    <dbReference type="Ensembl" id="ENSMODT00000085881.1">
        <property type="protein sequence ID" value="ENSMODP00000055577.1"/>
        <property type="gene ID" value="ENSMODG00000007208.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183121"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007208">
        <property type="expression patterns" value="Expressed in heart and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF51">
        <property type="entry name" value="THIALYSINE N-EPSILON-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="63"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="136" mass="15350" checksum="66B4F6429A032987" modified="2019-12-11" version="1">MAAVLIREATEGDCGDIMKMIRELAEFEKLLDQVKISEGALKTDGFGENPFYHCLVAEIPPESREPQGQGIGSKIIKKVAEVALEKGCSQFRLAVLDWNESAMDFYKARGAKDLTVAEGWRFFRFDNEAMRELVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H710</accession>
    <name>A0A5F8H710_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable ATP-dependent RNA helicase DDX5</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">DEAD box protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">DDX5</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Identified in the spliceosome C complex. Component of a ribonucleoprotein complex containing mRNAs and RNA-binding proteins including DDX5, HNRNPH2 and SRSF1 as well as splicing regulator ARVCF. Interacts with RBM4; the interaction occurs in an RNA-independent manner. Interacts with AGO1 and AGO2. Interacts with ESR1, AR, EP300, CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17. Interacts with BRDT. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active). Interacts with DHX36; this interaction occurs in a RNA-dependent manner. Interacts with NUPR1. Interacts with ERCC6. Interacts with DDX3X in the cytoplasm; this interaction may be more efficient when both proteins are unphosphorylated.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H710"/>
    <dbReference type="Ensembl" id="ENSMODT00000081931.1">
        <property type="protein sequence ID" value="ENSMODP00000055339.1"/>
        <property type="gene ID" value="ENSMODG00000003743.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154705"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003743">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012587">
        <property type="entry name" value="P68_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08061">
        <property type="entry name" value="P68HR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01414">
        <property type="entry name" value="P68HR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 26" id="KW-0347">Helicase</keyword>
    <keyword evidence="12 26" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="20" id="KW-0804">Transcription</keyword>
    <keyword evidence="18" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="28">
        <location>
            <begin position="85"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="29">
        <location>
            <begin position="249"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00032351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="535" mass="60575" checksum="1CD6B331808BBC5E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H711</accession>
    <name>A0A5F8H711_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Ryanodine receptor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cardiac muscle ryanodine receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Cardiac muscle ryanodine receptor-calcium release channel</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Type 2 ryanodine receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">RYR2</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000076847.1">
        <property type="protein sequence ID" value="ENSMODP00000055011.1"/>
        <property type="gene ID" value="ENSMODG00000007421.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154906"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007421">
        <property type="expression patterns" value="Expressed in heart and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23291">
        <property type="entry name" value="beta-trefoil_MIR_RyR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12877">
        <property type="entry name" value="SPRY1_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12878">
        <property type="entry name" value="SPRY2_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000040">
        <property type="entry name" value="Ryanodine receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000005">
        <property type="entry name" value="Ryanodine receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000001">
        <property type="entry name" value="Ryanodine receptor 2 (Cardiac)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000012">
        <property type="entry name" value="Ryanodine receptor 2 (Cardiac)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000006">
        <property type="entry name" value="Ryanodine receptor 2 (Cardiac)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000016">
        <property type="entry name" value="Ryanodine receptor 2 (Cardiac)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000017">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000003">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035761">
        <property type="entry name" value="SPRY1_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035764">
        <property type="entry name" value="SPRY2_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035762">
        <property type="entry name" value="SPRY3_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF7">
        <property type="entry name" value="RYANODINE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="14 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="7 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="4172"/>
            <end position="4198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="4218"/>
            <end position="4237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="4494"/>
            <end position="4513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="4687"/>
            <end position="4709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="4764"/>
            <end position="4787"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="28">
        <location>
            <begin position="103"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="28">
        <location>
            <begin position="218"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="28">
        <location>
            <begin position="279"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="28">
        <location>
            <begin position="344"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="26">
        <location>
            <begin position="592"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="26">
        <location>
            <begin position="1018"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="26">
        <location>
            <begin position="1350"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="27">
        <location>
            <begin position="3962"/>
            <end position="3997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1854"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="4355"/>
            <end position="4408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1870"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="4355"/>
            <end position="4398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00079227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="4887" mass="555450" checksum="51D59FF8744BCAF7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H712</accession>
    <name>A0A5F8H712_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Nucleotide binding oligomerization domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NOD2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the NOD1-NOD2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H712"/>
    <dbReference type="Ensembl" id="ENSMODT00000052195.1">
        <property type="protein sequence ID" value="ENSMODP00000055775.1"/>
        <property type="gene ID" value="ENSMODG00000013087.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160934"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013087">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08788">
        <property type="entry name" value="CARD_NOD2_2_CARD15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000940">
        <property type="entry name" value="Nucleotide-binding oligomerization domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CARD" evidence="17">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="CARD" evidence="17">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="18">
        <location>
            <begin position="266"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="984" mass="110757" checksum="2356164DA1E502A8" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H713</accession>
    <name>A0A5F8H713_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding motif single stranded interacting protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RBMS3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H713"/>
    <dbReference type="Ensembl" id="ENSMODT00000053091.1">
        <property type="protein sequence ID" value="ENSMODP00000055582.1"/>
        <property type="gene ID" value="ENSMODG00000015125.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157131"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015125">
        <property type="expression patterns" value="Expressed in endometrium and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12472">
        <property type="entry name" value="RRM1_RBMS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12475">
        <property type="entry name" value="RRM2_RBMS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000012">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000014">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034406">
        <property type="entry name" value="RBMS3_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="141"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="427" mass="46887" checksum="72EF170A754DA4CF" modified="2019-12-11" version="1">MGKRLEQPQMYPQYTYCYPHYLQTKQSYAPAPHPMAPPSPSTNSSSNNSSSNNNSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKTPPGVPAPTEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEVSYNGFYSSPYSIATNRMIPQTSITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPTMDHTMSMQPASMMGPLTQQMNHLSLGTTGTVRTKITMKIHELKCFPPYMTAAAPMQGTYIPQYTPVPPTAVPIEGVVADTSPQTVAPSSQEASAQQQQIAVETSNEHTPAYSYQQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H714</accession>
    <name>A0A5F8H714_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trafficking kinesin protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRAK2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the milton family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H714"/>
    <dbReference type="Ensembl" id="ENSMODT00000062704.1">
        <property type="protein sequence ID" value="ENSMODP00000055733.1"/>
        <property type="gene ID" value="ENSMODG00000015207.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158202"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015207">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006933">
        <property type="entry name" value="HAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051946">
        <property type="entry name" value="Intracell_Traff-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022154">
        <property type="entry name" value="TRAK1/2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751:SF13">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04849">
        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12448">
        <property type="entry name" value="Milton"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01424">
        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01423">
        <property type="entry name" value="Milton"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAP1 N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking kinesin-binding protein C-terminal" evidence="7">
        <location>
            <begin position="350"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="138"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="850" mass="94471" checksum="66F247C6B871FD6B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H716</accession>
    <name>A0A5F8H716_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho GTPase activating protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ARHGAP23</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H716"/>
    <dbReference type="Ensembl" id="ENSMODT00000069837.1">
        <property type="protein sequence ID" value="ENSMODP00000055016.1"/>
        <property type="gene ID" value="ENSMODG00000012570.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157982"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012570">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06756">
        <property type="entry name" value="PDZ_ARHGAP21_23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01253">
        <property type="entry name" value="PH_ARHGAP21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04395">
        <property type="entry name" value="RhoGAP_ARHGAP21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000014">
        <property type="entry name" value="Rho GTPase activating protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000066">
        <property type="entry name" value="Rho GTPase activating protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175:SF5">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="43"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="684"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="894"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="844"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1133" mass="125400" checksum="062466CBD68727AF" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H718</accession>
    <name>A0A5F8H718_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POC1 centriolar protein homolog A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">POC1 centriolar protein homolog B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Pat-interacting protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">WD repeat-containing protein 51A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">WD repeat-containing protein 51B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">POC1A</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May play an important role in centriole assembly and/or stability and ciliogenesis.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity. Acts as a positive regulator of centriole elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with POC1A. Interacts with FAM161A. Interacts with CEP44; the interaction is direct and recruits POC1B to centriolar microtubules. Forms a microtubule-associated complex with POC5, CETN2 and FAM161A. Interacts with CCDC15.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat POC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007500576.1">
        <property type="nucleotide sequence ID" value="XM_007500514.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H718"/>
    <dbReference type="FunCoup" id="A0A5F8H718">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055780"/>
    <dbReference type="Ensembl" id="ENSMODT00000082540.1">
        <property type="protein sequence ID" value="ENSMODP00000055780.1"/>
        <property type="gene ID" value="ENSMODG00000011717.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100031058"/>
    <dbReference type="CTD" id="25886"/>
    <dbReference type="GeneTree" id="ENSGT00940000157494"/>
    <dbReference type="InParanoid" id="A0A5F8H718"/>
    <dbReference type="OMA" id="LMIWHFK"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011717">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048871">
        <property type="term" value="P:multicellular organismal-level homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000567">
        <property type="entry name" value="POC1 centriolar protein homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000235">
        <property type="entry name" value="POC1 centriolar protein homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF2">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="416" mass="46601" checksum="581EC660FC003E6A" modified="2019-12-11" version="1">MALFKDSIRSYPGRKEDPSLERNFRGHKDAVTSVDFSANRKQLVSGSMDACLMIWHMKPHMRAYRFVGHKDAVMCVNFSPSGHLVASGSRDKTVRIWVPNLKGESTVFRAHTGTVRSVHFSSDGQSLVTASDDKTLKVWTVHRQKFLFSFTQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKTSRECVHSFCEHGGFVNYVDFHPSGTCIAAAGTDNTVKLWDIRTNRLLQHYQLHSAVVNALSFHPSGNYLITASNDSTLKILDLMEGRLLYTLHGHLGPATCVAFSRSGELFASGGTDEQVMVWKSNFDVTDYEDPLKTQRFASSSKSDAKILPEMDFSEVSLGMKSQDSFRNSQAEAVTIPATVTNTLEHIVSQLDVLTQTVSILEQRLTLTEDKLKQCLENQQLIMQSKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H721</accession>
    <name>A0A5F8H721_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Myoferlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MYOF</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferlin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000056622.1">
        <property type="protein sequence ID" value="ENSMODP00000055592.1"/>
        <property type="gene ID" value="ENSMODG00000006314.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154741"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006314">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000009">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000021">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000026">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000033">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000037">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012560">
        <property type="entry name" value="Ferlin_A-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF55">
        <property type="entry name" value="MYOFERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08165">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01200">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1861"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="35"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="191"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="962"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1121"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1371"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1607"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1897" mass="217438" checksum="D3B3AD64AB7BE55D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H722</accession>
    <name>A0A5F8H722_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Collagen alpha-1(XII) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">COL12A1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Trimer of identical chains each containing 190 kDa of non-triple-helical sequences.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000072949.1">
        <property type="protein sequence ID" value="ENSMODP00000055021.1"/>
        <property type="gene ID" value="ENSMODG00000018507.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154923"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018507">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005614">
        <property type="term" value="C:interstitial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="CDD" id="cd01482">
        <property type="entry name" value="vWA_collagen_alphaI-XII-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000018">
        <property type="entry name" value="collagen alpha-1(XII) chain isoform X1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000489">
        <property type="entry name" value="collagen alpha-1(XII) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000554">
        <property type="entry name" value="collagen alpha-1(XII) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000639">
        <property type="entry name" value="collagen alpha-1(XII) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000704">
        <property type="entry name" value="collagen alpha-1(XII) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000816">
        <property type="entry name" value="collagen alpha-1(XII) chain isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000008">
        <property type="entry name" value="Collagen type XII alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000121">
        <property type="entry name" value="Collagen type XII alpha 1 chain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000480">
        <property type="entry name" value="Collagen, type XII, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000001">
        <property type="entry name" value="Collagen, type XII, alpha 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF17">
        <property type="entry name" value="COLLAGEN ALPHA-1(XII) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="7" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023849066" description="Collagen alpha-1(XII) chain" evidence="17">
        <location>
            <begin position="24"/>
            <end position="3063"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="140"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="336"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="440"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="634"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="726"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="816"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="907"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="998"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1089"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="1199"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1387"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1477"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1568"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1660"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1756"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1851"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1937"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="2028"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="2119"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="2208"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="2324"/>
            <end position="2497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="799"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2291"/>
            <end position="2314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2745"/>
            <end position="2893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2927"/>
            <end position="3039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="2300"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="2785"/>
            <end position="2795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="2818"/>
            <end position="2827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="2829"/>
            <end position="2838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="2862"/>
            <end position="2871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="2938"/>
            <end position="2947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="2954"/>
            <end position="2963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="3063" mass="333258" checksum="3E03A911E460996F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H723</accession>
    <name>A0A5F8H723_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protrudin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Zinc finger FYVE domain-containing protein 27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ZFYVE27</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Growth cone membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H723"/>
    <dbReference type="Ensembl" id="ENSMODT00000074683.1">
        <property type="protein sequence ID" value="ENSMODP00000055743.1"/>
        <property type="gene ID" value="ENSMODG00000003907.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013298"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003907">
        <property type="expression patterns" value="Expressed in spinal cord and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071787">
        <property type="term" value="P:endoplasmic reticulum tubular network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15723">
        <property type="entry name" value="FYVE_protrudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000102">
        <property type="entry name" value="protrudin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042405">
        <property type="entry name" value="Protrudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14543">
        <property type="entry name" value="PROTRUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14543:SF1">
        <property type="entry name" value="PROTRUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="19">
        <location>
            <begin position="250"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="317" mass="35040" checksum="6907EDE12BB4EB53" modified="2019-12-11" version="1">TKALEEEGCGPEGALIAMPEAQPDSPPAPPKPPVLDLFNLVLFYKRLVVYLEPLKDAFDGILYLLSLIQLENFLNRLCNSCEAVYRVLYWENPVVSSQFYGLLLGSIFVLYLLPLCWILALLNSTLFLGNVEFYRVVAECRATLQQRMNPQLPGNTEDCLESDSGGRGVLLDCSSTPTPTEDLTPGSVEEAEEAEPDEEFKDAIEEDEEGSACSVEDDLALHDNGFMSKNEVIRSKVSRLTEKLRKRYPTNNFGNCASCSATFSVLKKRRSCSNCGNSFCSRCCSFKVLKSSMGATAPEAQRETVFVCGSCNQNLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H725</accession>
    <name>A0A5F8H725_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Propionyl-CoA carboxylase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PCCA</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H725"/>
    <dbReference type="FunCoup" id="A0A5F8H725">
        <property type="interactions" value="689"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055354"/>
    <dbReference type="Ensembl" id="ENSMODT00000062137.1">
        <property type="protein sequence ID" value="ENSMODP00000055354.1"/>
        <property type="gene ID" value="ENSMODG00000007637.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156083"/>
    <dbReference type="InParanoid" id="A0A5F8H725"/>
    <dbReference type="OMA" id="HIEIQVX"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007637">
        <property type="expression patterns" value="Expressed in kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041265">
        <property type="entry name" value="PCC_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18140">
        <property type="entry name" value="PCC_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="62"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="163"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="744" mass="82377" checksum="C02EA9C6348CE854" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H726</accession>
    <name>A0A5F8H726_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sortilin related VPS10 domain containing receptor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SORCS3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS10-related sortilin family. SORCS subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H726"/>
    <dbReference type="Ensembl" id="ENSMODT00000064154.1">
        <property type="protein sequence ID" value="ENSMODP00000055748.1"/>
        <property type="gene ID" value="ENSMODG00000010798.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234563"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010798">
        <property type="expression patterns" value="Expressed in spinal cord and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000001">
        <property type="entry name" value="Sortilin related VPS10 domain containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000083">
        <property type="entry name" value="Sortilin-related VPS10 domain containing receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000001">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF10">
        <property type="entry name" value="VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="11">
        <location>
            <begin position="807"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1150" mass="128904" checksum="DA76D81994B1CF24" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H727</accession>
    <name>A0A5F8H727_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Apoptotic protease-activating factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">APAF1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H727"/>
    <dbReference type="Ensembl" id="ENSMODT00000070446.1">
        <property type="protein sequence ID" value="ENSMODP00000055026.1"/>
        <property type="gene ID" value="ENSMODG00000007679.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157710"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007679">
        <property type="expression patterns" value="Expressed in spermatid and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08323">
        <property type="entry name" value="CARD_APAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000204">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000014">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.430:FF:000001">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.370:FF:000001">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000135">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000502">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041452">
        <property type="entry name" value="APAF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037963">
        <property type="entry name" value="APAF1_CARD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048975">
        <property type="entry name" value="WHD_APAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845:SF5">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17908">
        <property type="entry name" value="APAF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21296">
        <property type="entry name" value="WHD_APAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CARD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="610"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="652"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="694"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="738"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="834"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="958"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="999"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1040"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1166" mass="132953" checksum="92503B7BF575BA37" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H728</accession>
    <name>A0A5F8H728_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S6 kinase C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RPS6KC1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H728"/>
    <dbReference type="Ensembl" id="ENSMODT00000076208.1">
        <property type="protein sequence ID" value="ENSMODP00000055597.1"/>
        <property type="gene ID" value="ENSMODG00000003186.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155656"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003186">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02677">
        <property type="entry name" value="MIT_SNX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07287">
        <property type="entry name" value="PX_RPK118_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000005">
        <property type="entry name" value="ribosomal protein S6 kinase delta-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000017">
        <property type="entry name" value="ribosomal protein S6 kinase delta-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051866">
        <property type="entry name" value="Intracell_Sig-Traffick_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042132">
        <property type="entry name" value="PX_S6K-delta-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15508">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15508:SF2">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="678"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1063" mass="117726" checksum="20C5E9C8F8DC7EE7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H729</accession>
    <name>A0A5F8H729_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylhydrolase ARH1</fullName>
            <ecNumber evidence="4">3.2.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ADP-ribose-L-arginine cleaving enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylarginine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ADPRH</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.19" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H729"/>
    <dbReference type="Ensembl" id="ENSMODT00000054822.1">
        <property type="protein sequence ID" value="ENSMODP00000055790.1"/>
        <property type="gene ID" value="ENSMODG00000043232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100016348"/>
    <dbReference type="CTD" id="141"/>
    <dbReference type="GeneTree" id="ENSGT00530000063627"/>
    <dbReference type="OrthoDB" id="10250509at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000043232">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003875">
        <property type="term" value="F:ADP-ribosylarginine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051725">
        <property type="term" value="P:protein de-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4080.10:FF:000002">
        <property type="entry name" value="ADP-ribosylarginine hydrolase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012108">
        <property type="entry name" value="ADP-ribosylarg_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF26">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016939">
        <property type="entry name" value="ADP_ribslarg_hdr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="374" mass="41527" checksum="803B7E69F3D3952E" modified="2019-12-11" version="1">MISPKKTHHLGHIMSTGLLERYVAAMVLSAVGDSLGYFNRKWEFLLNGELIHQQLAKLGGLDAINIEGWRVSDDTVMHLATAEALITAGKEEDLTRVYSLIARHYKECMDDMDGRAPGTASVSNALKLEPDEPNGWRIPFNKHEGGCGAAMRAMCIGLRFPHPEQQDTLIQVSIESGRMTHHHPTGYLGAVASALFTAYAVNGKPPQEWGKGLMEVLPKAKNYIVQAGYYVKENLESWDYFQDQWEKYLKLRGISNGGPPTFPELFGVKERDEFYKSVSYSGWGGSSGHDAPLIAYDAILAAEDSWKELAHRAFFHGGDSDSTAAIAGCWWGVMHGFKGVSPSNYKRLEYKDRLEKAARALYALQSKESSVITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>F6W0T1</accession>
    <name>F6W0T1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NUAK1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_001374657.1">
        <property type="nucleotide sequence ID" value="XM_001374620.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6W0T1"/>
    <dbReference type="Ensembl" id="ENSMODT00000002400.5">
        <property type="protein sequence ID" value="ENSMODP00000002351.4"/>
        <property type="gene ID" value="ENSMODG00000001926.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100022976"/>
    <dbReference type="KEGG" id="mdo:100022976"/>
    <dbReference type="CTD" id="9891"/>
    <dbReference type="eggNOG" id="KOG0611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157255"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_42_1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001926">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14073">
        <property type="entry name" value="STKc_NUAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000226">
        <property type="entry name" value="NUAK family SNF1-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF86">
        <property type="entry name" value="NUAK FAMILY SNF1-LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="81"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="380"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="468"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000002351.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="683" mass="76016" checksum="3214A98742B41C63" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F6YXT2</accession>
    <name>F6YXT2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="10">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">POR</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="F6YXT2"/>
    <dbReference type="Ensembl" id="ENSMODT00000030079.3">
        <property type="protein sequence ID" value="ENSMODP00000028496.2"/>
        <property type="gene ID" value="ENSMODG00000013703.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156847"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013703">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000143">
        <property type="entry name" value="Cytochrome p450 oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="13">
        <location>
            <begin position="100"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="283"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="556"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000028496.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="608" mass="67764" checksum="C0F32F1F3782C9A0" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F7ALG0</accession>
    <name>F7ALG0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulatory factor X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RFX1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7ALG0"/>
    <dbReference type="Ensembl" id="ENSMODT00000015368.5">
        <property type="protein sequence ID" value="ENSMODP00000015089.4"/>
        <property type="gene ID" value="ENSMODG00000012044.5"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244879"/>
    <dbReference type="HOGENOM" id="CLU_010393_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012044">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000017">
        <property type="entry name" value="transcription factor RFX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007668">
        <property type="entry name" value="RFX1_trans_act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF23">
        <property type="entry name" value="MHC CLASS II REGULATORY FACTOR RFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04589">
        <property type="entry name" value="RFX1_trans_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="289"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="793"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000015089.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="829" mass="90730" checksum="6FF19D821958174C" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F7ALG9</accession>
    <name>F7ALG9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-phase cyclin A associated protein in the ER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SCAPER</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000015366.4">
        <property type="protein sequence ID" value="ENSMODP00000015087.3"/>
        <property type="gene ID" value="ENSMODG00000012042.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100025579"/>
    <dbReference type="CTD" id="49855"/>
    <dbReference type="eggNOG" id="KOG4722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011159"/>
    <dbReference type="HOGENOM" id="CLU_005178_0_0_1"/>
    <dbReference type="OrthoDB" id="71500at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012042">
        <property type="expression patterns" value="Expressed in testis and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000680">
        <property type="entry name" value="S phase cyclin A-associated protein in the endoplasmic reticulum"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032446">
        <property type="entry name" value="SCAPER_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434:SF2">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16501">
        <property type="entry name" value="SCAPER_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U1-type" evidence="3">
        <location>
            <begin position="859"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="925"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000015087.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1470" mass="165917" checksum="F248EEB2EF45EB43" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F7D3M9</accession>
    <name>F7D3M9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RNF43</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZNRF3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="F7D3M9"/>
    <dbReference type="Ensembl" id="ENSMODT00000018708.4">
        <property type="protein sequence ID" value="ENSMODP00000018375.4"/>
        <property type="gene ID" value="ENSMODG00000014712.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154006"/>
    <dbReference type="HOGENOM" id="CLU_037490_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014712">
        <property type="expression patterns" value="Expressed in testis and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7D3M9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000023">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF43 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000075">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase rnf43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040700">
        <property type="entry name" value="ZNRF-3_ecto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051073">
        <property type="entry name" value="ZNRF3_Arkadia_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16200">
        <property type="entry name" value="RING ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18212">
        <property type="entry name" value="ZNRF_3_ecto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="436"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="591"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="743"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000018375.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="943" mass="104503" checksum="578B8D149E751FCA" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>F7E6N0</accession>
    <name>F7E6N0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 501-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7E6N0"/>
    <dbReference type="Ensembl" id="ENSMODT00000006657.3">
        <property type="protein sequence ID" value="ENSMODP00000006522.3"/>
        <property type="gene ID" value="ENSMODG00000004295.4"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:103105007"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154411"/>
    <dbReference type="HOGENOM" id="CLU_002678_44_5_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004295">
        <property type="expression patterns" value="Expressed in heart and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7E6N0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004137">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002026">
        <property type="entry name" value="Zinc finger protein 160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000824">
        <property type="entry name" value="Zinc finger protein 184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001462">
        <property type="entry name" value="Zinc finger protein 502, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000229">
        <property type="entry name" value="Zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000330">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000006522.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="526" mass="60379" checksum="34EB0C43E8B0A216" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F7EY46</accession>
    <name>F7EY46_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U6 snRNA (guanine-N(2))-methyltransferase THUMPD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">THUMP domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">THUMPD2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome. This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanosine in U6 snRNA + S-adenosyl-L-methionine = N(2)-methylguanosine in U6 snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83423"/>
            <dbReference type="Rhea" id="RHEA-COMP:20128"/>
            <dbReference type="Rhea" id="RHEA-COMP:20129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:83424"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the heterodimeric THUMPD2-TRM112 methyltransferase complex; this complex forms an active tRNA methyltransferase, where TRMT112 acts as an activator of the catalytic subunit THUMPD2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7EY46"/>
    <dbReference type="Ensembl" id="ENSMODT00000011601.3">
        <property type="protein sequence ID" value="ENSMODP00000011381.3"/>
        <property type="gene ID" value="ENSMODG00000009129.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063557"/>
    <dbReference type="HOGENOM" id="CLU_045692_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009129">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106346">
        <property type="term" value="F:snRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11715">
        <property type="entry name" value="THUMP_AdoMetMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.30:FF:000005">
        <property type="entry name" value="THUMP domain containing 2, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000177">
        <property type="entry name" value="THUMP domain containing 2, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF1">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="14">
        <location>
            <begin position="138"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011381.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="482" mass="54254" checksum="3771B71B480D5B91" modified="2019-12-11" version="2">MLSYLNRPRKIRREAQNSGLLQVEYISGKVFFTTNAGLTMLKQLKSAERLFLLLKRQPPLIIPSGRKGKIFNEIQRLVTEDPMCWVHAISIWRSLLELEEKLPLEVSKPHKRTARENENIITKKLKIEQTLVMLGDTECQLEKQKNDKPQEHENLKTEKENFQEESENDGEKGADHQGQFTFRVSCRCSGTIAKTFTTEEVGRVIGIALIKQFGWKADLRNPKLEIFIHLNDIYSVVGIPVFRLPLASRAYIKVAGLRSTIAWTMASLAEINVGAVVLDPMCGLGTILLEAAKEWPNAYYLGADVSDSQLSGACDNLKSAGLVDRIELLKFSVTELPLLSKSVDVIISDIPFGKKFKLGKDIKSILHEMERVLCVGGTIVLLLSEELHRNLQGGKESNVLWNSSKANTDEFKIPKFVNDQENNGIQENVSSSSEDHRQECLDQEPIFGTLVQMESHKVSLGRTEAFILKYKKIHASGLQQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>F7F9S4</accession>
    <name>F7F9S4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Gamma-aminobutyric acid type A receptor subunit gamma2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">GABRG2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7F9S4"/>
    <dbReference type="Ensembl" id="ENSMODT00000009745.4">
        <property type="protein sequence ID" value="ENSMODP00000009557.4"/>
        <property type="gene ID" value="ENSMODG00000007695.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156685"/>
    <dbReference type="HOGENOM" id="CLU_010920_2_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007695">
        <property type="expression patterns" value="Expressed in spinal cord and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19000">
        <property type="entry name" value="LGIC_ECD_GABAAR_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19054">
        <property type="entry name" value="LGIC_TM_GABAAR_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000003">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit gamma-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005437">
        <property type="entry name" value="GABRG-1/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01620">
        <property type="entry name" value="GABAARGAMMA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="35"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="245"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR605437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000009557.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="441" mass="51297" checksum="AA599F18984F7211" modified="2019-12-11" version="3">LGLSSQKSDDDYEDYASNKTWVLTPKVPEGDVTFILNGLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPQEEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3G1</accession>
    <name>A0A5F8G3G1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CAMK2G</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="RefSeq" id="XP_001363366.1">
        <property type="nucleotide sequence ID" value="XM_001363329.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3G1"/>
    <dbReference type="Ensembl" id="ENSMODT00000055226.1">
        <property type="protein sequence ID" value="ENSMODP00000041987.1"/>
        <property type="gene ID" value="ENSMODG00000000536.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100010898"/>
    <dbReference type="KEGG" id="mdo:100010898"/>
    <dbReference type="CTD" id="818"/>
    <dbReference type="GeneTree" id="ENSGT00940000156481"/>
    <dbReference type="OrthoDB" id="336747at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000536">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14086">
        <property type="entry name" value="STKc_CaMKII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000001">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000002">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000001">
        <property type="entry name" value="calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="14"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="527" mass="59049" checksum="13024FE65E35DEC0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3G2</accession>
    <name>A0A5F8G3G2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Kinesin family member 20B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KIF20B</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000052089.1">
        <property type="protein sequence ID" value="ENSMODP00000042004.1"/>
        <property type="gene ID" value="ENSMODG00000007283.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155989"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007283">
        <property type="expression patterns" value="Expressed in hindlimb bud and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01368">
        <property type="entry name" value="KISc_KIF23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21786">
        <property type="entry name" value="RBD_KIF20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF29">
        <property type="entry name" value="KINESIN FAMILY MEMBER 20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="58"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1588"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1746"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1799"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="559"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="657"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="831"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1038"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1350"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1475"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1540"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1588"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1808"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="152"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1818" mass="210123" checksum="0D8AE1318B0DD4B5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3G3</accession>
    <name>A0A5F8G3G3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UBR1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="Ensembl" id="ENSMODT00000085549.1">
        <property type="protein sequence ID" value="ENSMODP00000042018.1"/>
        <property type="gene ID" value="ENSMODG00000017858.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183075"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017858">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19678">
        <property type="entry name" value="UBR-box_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047507">
        <property type="entry name" value="UBR-box_UBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF27">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="30"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="8">
        <location>
            <begin position="30"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="688"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1595" mass="182125" checksum="E7DFACCC052B770E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3G8</accession>
    <name>A0A5F8G3G8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Unconventional myosin-Ib</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Myosin I alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MYO1B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001369628.1">
        <property type="nucleotide sequence ID" value="XM_001369591.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3G8"/>
    <dbReference type="Ensembl" id="ENSMODT00000065407.1">
        <property type="protein sequence ID" value="ENSMODP00000041965.1"/>
        <property type="gene ID" value="ENSMODG00000011829.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021672"/>
    <dbReference type="CTD" id="4430"/>
    <dbReference type="GeneTree" id="ENSGT00940000155752"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011829">
        <property type="expression patterns" value="Expressed in liver and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000013">
        <property type="entry name" value="LOW QUALITY PROTEIN: unconventional myosin-Ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000007">
        <property type="entry name" value="Myosin-ib isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000004">
        <property type="entry name" value="unconventional myosin-Ib isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF277">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 15" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="15"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="17">
        <location>
            <begin position="894"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="15">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1078" mass="124906" checksum="6934E4AB6990A682" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3G9</accession>
    <name>A0A5F8G3G9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NFIX</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds DNA as a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CTF/NF-I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3G9"/>
    <dbReference type="Ensembl" id="ENSMODT00000075646.1">
        <property type="protein sequence ID" value="ENSMODP00000042023.1"/>
        <property type="gene ID" value="ENSMODG00000011587.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182916"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011587">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000647">
        <property type="entry name" value="CTF/NFI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020604">
        <property type="entry name" value="CTF/NFI_DNA-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019739">
        <property type="entry name" value="CTF/NFI_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019548">
        <property type="entry name" value="CTF/NFI_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492:SF3">
        <property type="entry name" value="NUCLEAR FACTOR 1 X-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="NUCLEAR FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00859">
        <property type="entry name" value="CTF_NFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10524">
        <property type="entry name" value="NfI_DNAbd_pre-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00349">
        <property type="entry name" value="CTF_NFI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51080">
        <property type="entry name" value="CTF_NFI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0010">Activator</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CTF/NF-I" evidence="11">
        <location>
            <begin position="6"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="394" mass="43683" checksum="5CF4ED519A9DD0C2" modified="2019-12-11" version="1">MGSTECNGDISCLCDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEYREDFVLTITGKKAPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVGTASGPNFSLGGLGELQLLPHKHVTLGTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGTGQATGQHSQRQAPPLPTGLSASDPGTATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3H1</accession>
    <name>A0A5F8G3H1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FBXO3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3H1"/>
    <dbReference type="Ensembl" id="ENSMODT00000088087.1">
        <property type="protein sequence ID" value="ENSMODP00000041981.1"/>
        <property type="gene ID" value="ENSMODG00000009829.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100031407"/>
    <dbReference type="CTD" id="26273"/>
    <dbReference type="GeneTree" id="ENSGT00940000153571"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009829">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd22084">
        <property type="entry name" value="F-box_FBXO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052121">
        <property type="entry name" value="F-box_SCF_Substrate_Recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003967">
        <property type="entry name" value="PRK05461.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550:SF1">
        <property type="entry name" value="F-BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="15"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="ApaG" evidence="5">
        <location>
            <begin position="283"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="459" mass="52581" checksum="E3F77DEE1DA59067" modified="2019-12-11" version="1">MAAAAAAALGAEEPELSLELLPTDPLLLIFSFLDYRDLVSCSCVSRRLNQLSNHDPLWRRHCKKYWLLSETEKTQKNKSWISLFKETYIDLGRYIQHYATLKKAWDDLERYLGQRCPRMIGSLKDSVEERELDAVEAQIGCKLPNDYRCSFRIHNGQKLVVPGLMGSMALSNHYRSEDLLDIDTAAGGFLQRQGLRQCLPLTFCIHTGLSQYMALESVEGRNKYEIFYQCPDQMARNPSAIDMFITGASYSEWFTSYVHNVVTGGYPIIRDQIFRYVHDKGCVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSKDALPEKTCQLDSRYWRITNAKGEIEEVQGPGVVGEFPILSPGRVYEYTSCTTFSTTSGYMEGHYTFHLLYYKDRIFNVAIPRFHMVCPTFKVSTTPRETHNECAVIEEDEESTDSENFEDQPRLLDFSPPTGHCPRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3H3</accession>
    <name>A0A5F8G3H3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Zinc finger protein 445</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3H3"/>
    <dbReference type="Ensembl" id="ENSMODT00000086856.1">
        <property type="protein sequence ID" value="ENSMODP00000042028.1"/>
        <property type="gene ID" value="ENSMODG00000013724.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155965"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013724">
        <property type="expression patterns" value="Expressed in ovary and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001351">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000380">
        <property type="entry name" value="zinc finger protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000247">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001530">
        <property type="entry name" value="Zinc finger protein 268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000128">
        <property type="entry name" value="zinc finger protein 268 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000010">
        <property type="entry name" value="Zinc finger protein 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000188">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="17">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="18">
        <location>
            <begin position="214"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="922"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="950"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="145"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="255"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="975" mass="113037" checksum="15677C8893AABACC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3H4</accession>
    <name>A0A5F8G3H4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fibronectin type III domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FNDC1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be an activator of G protein signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000064339.1">
        <property type="protein sequence ID" value="ENSMODP00000041970.1"/>
        <property type="gene ID" value="ENSMODG00000007540.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063558"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007540">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000778">
        <property type="entry name" value="Fibronectin type III domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001228">
        <property type="entry name" value="Fibronectin type III domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001330">
        <property type="entry name" value="Fibronectin type III domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049109">
        <property type="entry name" value="TARSH/FNDC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23197:SF8">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23197">
        <property type="entry name" value="TARSH-RELATED FIBRONECTIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21731">
        <property type="entry name" value="TARSH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023929464" description="Fibronectin type III domain-containing protein 1" evidence="10">
        <location>
            <begin position="28"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="33"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="151"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="256"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="356"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="1670"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1525"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="784"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="869"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="897"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="961"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1002"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1058"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1083"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1140"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1173"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1227"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1261"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1272"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1327"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1347"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1392"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1525"/>
            <end position="1559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1906" mass="210586" checksum="A161FD64B9E6A6CA" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3H5</accession>
    <name>A0A5F8G3H5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Receptor-type tyrosine-protein kinase FLT3</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">FL cytokine receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Fms-like tyrosine kinase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">FLT3</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. Interacts with FIZ1 following ligand activation. Interacts with FES, FER, LYN, FGR, HCK, SRC and GRB2. Interacts with PTPRJ/DEP-1 and PTPN11/SHP2. Interacts with RNF115 and RNF126.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 31">Membrane</location>
            <topology evidence="2 31">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="31">Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3H5"/>
    <dbReference type="Ensembl" id="ENSMODT00000059336.1">
        <property type="protein sequence ID" value="ENSMODP00000042002.1"/>
        <property type="gene ID" value="ENSMODG00000009045.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160575"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009045">
        <property type="expression patterns" value="Expressed in hindlimb bud and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001159">
        <property type="entry name" value="Fms related tyrosine kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000426">
        <property type="entry name" value="Receptor-type tyrosine-protein kinase FLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000661">
        <property type="entry name" value="receptor-type tyrosine-protein kinase FLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000366">
        <property type="entry name" value="receptor-type tyrosine-protein kinase FLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001824">
        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF356">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00240">
        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 27 30" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19 31" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="28" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 27 30" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17 31" id="KW-0675">Receptor</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 31 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 33" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="35">
        <location>
            <begin position="256"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="34">
        <location>
            <begin position="592"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="946"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="26">
        <location>
            <position position="791"/>
        </location>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <begin position="599"/>
            <end position="606"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27 30">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <begin position="674"/>
            <end position="680"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="795"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for interaction with phosphotyrosine-binding proteins" evidence="29">
        <location>
            <position position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00059422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00064207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU000311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="973" mass="110260" checksum="55A776F4ED77CC59" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3H9</accession>
    <name>A0A5F8G3H9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Leukocyte immunoglobulin-like receptor subfamily A member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC103097245</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3H9"/>
    <dbReference type="Ensembl" id="ENSMODT00000061905.1">
        <property type="protein sequence ID" value="ENSMODP00000042024.1"/>
        <property type="gene ID" value="ENSMODG00000041901.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263478"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000041901">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000049">
        <property type="entry name" value="Leukocyte immunoglobulin-like receptor subfamily B member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050412">
        <property type="entry name" value="Ig-like_Receptors_ImmuneReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738:SF179">
        <property type="entry name" value="LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738">
        <property type="entry name" value="MHC CLASS I NK CELL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="218" mass="23606" checksum="D10B674EC5D6C1F4" modified="2019-12-11" version="1">MSLPLSSPVSLPLSLSLSLSVSPSFCLSLSLSLSVSVSVSLSVCLSVCLSFPLCLSAYPNITFPTNSSLSPLDASHSGYYNRPRLSAEPSQDVAWGHNVTLRCLSVQGIDRFVLYRVEGANSSPWRDPQSHPDFLIRAVAAPHEGNYSCYEFHSQHPYAWSLPSAPLELRVTDATSQDYTKGNLIRLSLAGLILLILGVLLADAWHTGRRYQGAVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3I1</accession>
    <name>A0A5F8G3I1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apoptotic chromatin condensation inducer 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ACIN1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3I1"/>
    <dbReference type="Ensembl" id="ENSMODT00000055456.1">
        <property type="protein sequence ID" value="ENSMODP00000041991.1"/>
        <property type="gene ID" value="ENSMODG00000005083.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00710000106790"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005083">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="548"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="829"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1110"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1268" mass="142509" checksum="54CC99126D9D08D1" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3I2</accession>
    <name>A0A5F8G3I2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Unc-13 homolog A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000070640.1">
        <property type="protein sequence ID" value="ENSMODP00000041975.1"/>
        <property type="gene ID" value="ENSMODG00000006976.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154929"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006976">
        <property type="expression patterns" value="Expressed in cerebellum and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20859">
        <property type="entry name" value="C1_Munc13-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08394">
        <property type="entry name" value="C2A_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08395">
        <property type="entry name" value="C2C_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1100:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000002">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000031">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF1">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023897048" description="Unc-13 homolog A" evidence="16">
        <location>
            <begin position="22"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="18">
        <location>
            <begin position="553"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="659"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="19">
        <location>
            <begin position="1045"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="20">
        <location>
            <begin position="1293"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="1486"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="172"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1646"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1646"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1657"/>
            <end position="1671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1671" mass="189398" checksum="7DDD59BFF553CAC1" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3I3</accession>
    <name>A0A5F8G3I3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoinositide kinase, FYVE-type zinc finger containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PIKFYVE</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3I3"/>
    <dbReference type="Ensembl" id="ENSMODT00000080758.1">
        <property type="protein sequence ID" value="ENSMODP00000042038.1"/>
        <property type="gene ID" value="ENSMODG00000015918.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156307"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015918">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04448">
        <property type="entry name" value="DEP_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000206">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043548">
        <property type="entry name" value="PIKfyve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037378">
        <property type="entry name" value="PIKfyve_DEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46715">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46715:SF1">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="269"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="452" mass="50398" checksum="53BDF9E615FBE7FD" modified="2019-12-11" version="1">MATDDKTSPTLDSSNDLPRSPTSPSHLTHFKPLTPDQDEPPFKSAYSSFVNLFRFSKERPEGGQGDQQPLSGSWTSPQHSSRTQSVRSPISYKKPINEELHRRSSTVLGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDSASSVSLLDPIEPRTPVGSRKASRNIFLEEDLAWQSLIHPDSSNTTLSTRLVSVQEDAGKSPARNRSASITNLSLDRSGSPMVPSYETSVSPQANRTYVKTETSEDERKILLDSVQLKDLWKKICHHSTGMEFQDHRYWLRTHPNCIVGKELVNWLIRNGHVTTRAQAIAIGQAMVDGRWLDCVSHHDQIFRDEYALYKPLQSTEFSETPSPDSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGEENLANSASPSKRTSVSSFQSTMDSDSAASISLNVELDNVNFHIKKPSKYPHVPPHPADQKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3I4</accession>
    <name>A0A5F8G3I4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine rich repeats and calponin homology domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LRCH3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_056649575.1">
        <property type="nucleotide sequence ID" value="XM_056793597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3I4"/>
    <dbReference type="Ensembl" id="ENSMODT00000057802.1">
        <property type="protein sequence ID" value="ENSMODP00000042029.1"/>
        <property type="gene ID" value="ENSMODG00000018392.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100014915"/>
    <dbReference type="CTD" id="84859"/>
    <dbReference type="GeneTree" id="ENSGT00940000158330"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018392">
        <property type="expression patterns" value="Expressed in forelimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000021">
        <property type="entry name" value="Leucine-rich repeat and calponin homology domain-containing protein 1 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000007">
        <property type="entry name" value="Leucine-rich repeat and calponin homology domain-containing protein 1 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF44">
        <property type="entry name" value="LEUCINE RICH REPEATS AND CALPONIN HOMOLOGY DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="635"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="786" mass="87809" checksum="187A57B98720DC86" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3I5</accession>
    <name>A0A5F8G3I5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Synaptoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SYNPR</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptophysin/synaptobrevin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3I5"/>
    <dbReference type="Ensembl" id="ENSMODT00000067333.1">
        <property type="protein sequence ID" value="ENSMODP00000042012.1"/>
        <property type="gene ID" value="ENSMODG00000002954.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234637"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002954">
        <property type="expression patterns" value="Expressed in spinal cord and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001285">
        <property type="entry name" value="Synaptophysin/porin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306">
        <property type="entry name" value="SYNAPTOPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306:SF16">
        <property type="entry name" value="SYNAPTOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00220">
        <property type="entry name" value="SYNAPTOPHYSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00604">
        <property type="entry name" value="SYNAPTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="23"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="221" mass="24040" checksum="07F7B8415E0CA988" modified="2019-12-11" version="1">ISLSLSLSLSLSLSLSLSLSLSLSLSLSLSSLSLFQLFAIFAFATCGGYSGALRLSVDCANKTDSDFSIDIDFAYPFRLHQVTFEVPTCEGKRREKLALIGDFSSSAEFFVTIAVFAFLYSLAATVVYIFFQNKYRENNRGPLVDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLVSACKQQSNKCAAVHSPVMSSLNTSVVNPKVDVSAHRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3I6</accession>
    <name>A0A5F8G3I6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transforming acidic coiled-coil containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TACC3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007496924.1">
        <property type="nucleotide sequence ID" value="XM_007496862.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3I6"/>
    <dbReference type="Ensembl" id="ENSMODT00000057080.1">
        <property type="protein sequence ID" value="ENSMODP00000041996.1"/>
        <property type="gene ID" value="ENSMODG00000004284.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100024199"/>
    <dbReference type="CTD" id="10460"/>
    <dbReference type="GeneTree" id="ENSGT00940000158858"/>
    <dbReference type="OrthoDB" id="10255048at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004284">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000001">
        <property type="entry name" value="Transforming acidic coiled-coil-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057663">
        <property type="entry name" value="TACC3_Aurora-A_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF4">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25777">
        <property type="entry name" value="Aurora-A_bind_TACC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="664"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="673"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="870" mass="97491" checksum="79D8304A11DDDD03" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3I7</accession>
    <name>A0A5F8G3I7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xin actin binding repeat containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">XIRP2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Xin repeats bind F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Xin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000058359.1">
        <property type="protein sequence ID" value="ENSMODP00000041980.1"/>
        <property type="gene ID" value="ENSMODG00000007546.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063779"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007546">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012510">
        <property type="entry name" value="Actin-binding_Xin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030072">
        <property type="entry name" value="XIRP1/XIRP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22591">
        <property type="entry name" value="XIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22591:SF1">
        <property type="entry name" value="XIN ACTIN-BINDING REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08043">
        <property type="entry name" value="Xin"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51389">
        <property type="entry name" value="XIN"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="833"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="866"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="939"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="978"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="1090"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="1127"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="1192"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="1230"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="repeat" description="Xin" evidence="5">
        <location>
            <begin position="1265"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2042"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2122"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2425"/>
            <end position="2460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2530"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2785"/>
            <end position="2815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2858"/>
            <end position="2953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2746"/>
            <end position="2773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="2046"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2129"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2202"/>
            <end position="2227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2228"/>
            <end position="2244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2426"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2538"/>
            <end position="2562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2584"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2798"/>
            <end position="2808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2858"/>
            <end position="2877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2888"/>
            <end position="2899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2927"/>
            <end position="2943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="3290" mass="373679" checksum="DEACEDB09E70AFF5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3I8</accession>
    <name>A0A5F8G3I8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Attractin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">ATRN</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer and homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000060614.1">
        <property type="protein sequence ID" value="ENSMODP00000042043.1"/>
        <property type="gene ID" value="ENSMODG00000004575.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157346"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004575">
        <property type="expression patterns" value="Expressed in liver and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000031">
        <property type="entry name" value="attractin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000034">
        <property type="entry name" value="Attractin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000012">
        <property type="entry name" value="Attractin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000079">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000164">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000008">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056732">
        <property type="entry name" value="GBD_ATRN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF3">
        <property type="entry name" value="ATTRACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24972">
        <property type="entry name" value="GBD_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="15 20" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="10 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1278"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="22">
        <location>
            <begin position="130"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="25">
        <location>
            <begin position="794"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="1062"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1079"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1091"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1375" mass="153181" checksum="F1E9E8E35B29D82C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3J0</accession>
    <name>A0A5F8G3J0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-alpha-acetyltransferase 35, NatC auxiliary subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein MAK10 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NAA35</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway. Involved in regulation of apoptosis and proliferation of smooth muscle cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3J0"/>
    <dbReference type="Ensembl" id="ENSMODT00000054690.1">
        <property type="protein sequence ID" value="ENSMODP00000042017.1"/>
        <property type="gene ID" value="ENSMODG00000008181.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002445"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008181">
        <property type="expression patterns" value="Expressed in heart and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="9">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like N-terminal" evidence="9">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="10">
        <location>
            <begin position="321"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="708" mass="81400" checksum="9AAA46800B58BDB4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3J2</accession>
    <name>A0A5F8G3J2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PDE6A</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3J2"/>
    <dbReference type="Ensembl" id="ENSMODT00000066592.1">
        <property type="protein sequence ID" value="ENSMODP00000042039.1"/>
        <property type="gene ID" value="ENSMODG00000009879.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161330"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009879">
        <property type="expression patterns" value="Expressed in uterus and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000001">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000010">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0140">cGMP</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="7">
        <location>
            <begin position="483"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="764"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="795" mass="92659" checksum="836CD7C7E5A770D7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3J4</accession>
    <name>A0A5F8G3J4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho GTPase-activating protein 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Rho-type GTPase-activating protein 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARHGAP19</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3J4"/>
    <dbReference type="Ensembl" id="ENSMODT00000077826.1">
        <property type="protein sequence ID" value="ENSMODP00000042022.1"/>
        <property type="gene ID" value="ENSMODG00000004364.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157331"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004364">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04392">
        <property type="entry name" value="RhoGAP_ARHGAP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000022">
        <property type="entry name" value="rho GTPase-activating protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047941">
        <property type="entry name" value="ARHGAP19_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="139"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00055252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00083391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="494" mass="55995" checksum="C68F4887BF86E29D" modified="2019-12-11" version="1">MERALKVQLRPSQSRARGSKHSANQKGQEEWLKIITKMATESSSDGEVQYQGQKRRDAICNFVICNDASLRGQPIIFNPDFFVEKLRHEKPEVFTELVVSNITRLIDLPGTELAQLMGEVDLKFPSGTGTASGFFRSLMSLKRKEKGVVFGSPLTEEGIAQIYQLIEYLHKNLRVEGLFRIPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFLGELPEPLLTHRHFHAHLKIADLMQFDDKGNKTSIPDKERQIEALQLLFLILPPPNRSLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHILWPKNVTANDLQENITKLNNGMAFMIKHSQKLFKAPVYVRECARLHYLGSRTHASKDDLDLPTSCNSKDFQLSKSHKRPRMNTCFQQEETQQRTEEALRELLQHVHNMPDSAKKKKLIRQFNKQPAAQTPGSDGATPQFQKRTRSRSFSGLIKVCSGSPALKGTPARLKFSEGKKEGRKGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3J5</accession>
    <name>A0A5F8G3J5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein SERAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine active site-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SERAC1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SERAC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3J5"/>
    <dbReference type="Ensembl" id="ENSMODT00000053210.1">
        <property type="protein sequence ID" value="ENSMODP00000042006.1"/>
        <property type="gene ID" value="ENSMODG00000007736.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003560"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007736">
        <property type="expression patterns" value="Expressed in placenta and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="ARM" evidence="16">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="641" mass="73067" checksum="EFAF82BFC59DE1B2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3J7</accession>
    <name>A0A5F8G3J7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Src substrate cortactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">CTTN</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
            <location evidence="5">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell projection</location>
            <location evidence="10">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell projection</location>
            <location evidence="8">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
            <location evidence="9">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Membrane</location>
            <location evidence="11">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3J7"/>
    <dbReference type="FunCoup" id="A0A5F8G3J7">
        <property type="interactions" value="928"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042053"/>
    <dbReference type="Ensembl" id="ENSMODT00000053818.1">
        <property type="protein sequence ID" value="ENSMODP00000042053.1"/>
        <property type="gene ID" value="ENSMODG00000045767.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158565"/>
    <dbReference type="InParanoid" id="A0A5F8G3J7"/>
    <dbReference type="OMA" id="VGFQEQD"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000045767">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005522">
        <property type="term" value="F:profilin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097062">
        <property type="term" value="P:dendritic spine maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097191">
        <property type="term" value="P:extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001237">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045987">
        <property type="term" value="P:positive regulation of smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901524">
        <property type="term" value="P:regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006930">
        <property type="term" value="P:substrate-dependent cell migration, cell extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11959">
        <property type="entry name" value="SH3_Cortactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000087">
        <property type="entry name" value="Src substrate cortactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035716">
        <property type="entry name" value="Cortactin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003134">
        <property type="entry name" value="Hs1_Cortactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF15">
        <property type="entry name" value="SRC SUBSTRATE CORTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02218">
        <property type="entry name" value="HS1_rep"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51090">
        <property type="entry name" value="CORTACTIN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0965">Cell junction</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="25" id="KW-0966">Cell projection</keyword>
    <keyword evidence="23" id="KW-0168">Coated pit</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="24" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 27" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="20" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="SH3" evidence="29">
        <location>
            <begin position="459"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00073863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="517" mass="57037" checksum="83AD726C73FA6415" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3J8</accession>
    <name>A0A5F8G3J8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Myc box-dependent-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Amphiphysin II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Amphiphysin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Bridging integrator 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BIN1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <location evidence="16">Sarcolemma</location>
            <location evidence="16">T-tubule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3J8"/>
    <dbReference type="Ensembl" id="ENSMODT00000076577.1">
        <property type="protein sequence ID" value="ENSMODP00000042044.1"/>
        <property type="gene ID" value="ENSMODG00000018719.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182882"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018719">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12139">
        <property type="entry name" value="SH3_Bin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000013">
        <property type="entry name" value="Amphiphysin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000029">
        <property type="entry name" value="myc box-dependent-interacting protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003005">
        <property type="entry name" value="Amphiphysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035471">
        <property type="entry name" value="Amphiphysin-2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003023">
        <property type="entry name" value="Amphiphysin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514:SF4">
        <property type="entry name" value="MYC BOX-DEPENDENT-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01253">
        <property type="entry name" value="AMPHIPHYSIN2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 21" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="25">
        <location>
            <begin position="29"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="24">
        <location>
            <begin position="412"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="278"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00080400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="485" mass="53970" checksum="66253B33A28AE81C" modified="2019-12-11" version="1">MAELGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLTECLQEVYEPDWPGREETNKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVSLEKQHGSNTFTVKAQPRKKTKLFSRLRRKKSSDNAPTKGNKSPSPPPDGSPAGTPEIKVNHEPEPASLDTPGAAIPKSPSQPGDVTEAGGTKPVAVLEGAKETAASDGASSSLPAVVVETFPATVNGTVEGSTPSKRSDLPPGFMFKVQAQHDYTATDSDELQLKAGDVVLVIPFENPEEQDEGWLMGVKESDWHQHKELEKCRGVFPENFTEKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3K0</accession>
    <name>A0A5F8G3K0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CFAP20 domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CFAP20DC</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3K0"/>
    <dbReference type="Ensembl" id="ENSMODT00000060327.1">
        <property type="protein sequence ID" value="ENSMODP00000042027.1"/>
        <property type="gene ID" value="ENSMODG00000002419.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100016432"/>
    <dbReference type="CTD" id="200844"/>
    <dbReference type="GeneTree" id="ENSGT00390000005497"/>
    <dbReference type="OrthoDB" id="10261083at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002419">
        <property type="expression patterns" value="Expressed in heart and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="793" mass="88772" checksum="36D5724096F7D24C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3K6</accession>
    <name>A0A5F8G3K6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luc7-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LUC7L3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds cAMP regulatory element DNA sequence. Plays a role in RNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May interact with SFRS1 and form homodimers. Interacts with JMJD6. Interacts with RBM25. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with RRP1B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056672581.1">
        <property type="nucleotide sequence ID" value="XM_056816603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3K6"/>
    <dbReference type="FunCoup" id="A0A5F8G3K6">
        <property type="interactions" value="3281"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042032"/>
    <dbReference type="Ensembl" id="ENSMODT00000087952.1">
        <property type="protein sequence ID" value="ENSMODP00000042032.1"/>
        <property type="gene ID" value="ENSMODG00000012711.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100013039"/>
    <dbReference type="CTD" id="51747"/>
    <dbReference type="GeneTree" id="ENSGT00950000183213"/>
    <dbReference type="InParanoid" id="A0A5F8G3K6"/>
    <dbReference type="OMA" id="PCTRIHD"/>
    <dbReference type="OrthoDB" id="10266921at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012711">
        <property type="expression patterns" value="Expressed in ovary and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="489" mass="58264" checksum="1C5F71F2ECA2FBA4" modified="2019-12-11" version="1">MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPERDDRLKKEKQEREEREKEREREREERERKRRREEEEREKERVRDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHERSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKDKRGSDDKKSSVKSSSREKQSEDPNTESKESDAKNEVNGTSEDIKSEVQRKYAQMKMELSRVRRHTKAPSEGKDSVVLQNILRYIVLSQLFCSRLVPPLSVPLWNYCPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3K8</accession>
    <name>A0A5F8G3K8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>nitrate(in) = nitrate(out)</text>
            <dbReference type="Rhea" id="RHEA:34923"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homodimer. Interacts with BSND.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="13616.ENSMODP00000042054"/>
    <dbReference type="Ensembl" id="ENSMODT00000077552.1">
        <property type="protein sequence ID" value="ENSMODP00000042054.1"/>
        <property type="gene ID" value="ENSMODG00000003369.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164106"/>
    <dbReference type="InParanoid" id="A0A5F8G3K8"/>
    <dbReference type="OMA" id="NHEDMEP"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003369">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03683">
        <property type="entry name" value="ClC_1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000012">
        <property type="entry name" value="Chloride channel K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002250">
        <property type="entry name" value="Cl_channel-K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF3">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-KB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01119">
        <property type="entry name" value="CLCHANNELKDY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 20" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 21" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="848"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="884"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="925"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="974"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1044"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1073"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1105"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1143"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="552"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="1200"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1330" mass="148082" checksum="A22C64663BC41E8C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3K9</accession>
    <name>A0A5F8G3K9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RAS p21 protein activator 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RASA3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3K9"/>
    <dbReference type="Ensembl" id="ENSMODT00000086981.1">
        <property type="protein sequence ID" value="ENSMODP00000042000.1"/>
        <property type="gene ID" value="ENSMODG00000003579.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157953"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003579">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08401">
        <property type="entry name" value="C2A_RasA2_RasA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000011">
        <property type="entry name" value="Ras GTPase-activating protein 2 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF53">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00107">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="91"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="9">
        <location>
            <begin position="291"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="528"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="765" mass="87804" checksum="F212F5B9F3480EA7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUI8</accession>
    <name>A0A5F8GUI8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine rich repeat containing 63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LRRC63</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUI8"/>
    <dbReference type="Ensembl" id="ENSMODT00000082176.1">
        <property type="protein sequence ID" value="ENSMODP00000051210.1"/>
        <property type="gene ID" value="ENSMODG00000029107.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000173288"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000029107">
        <property type="expression patterns" value="Expressed in spermatid and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF62">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="547" mass="62978" checksum="2E9CD124E9049121" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUI9</accession>
    <name>A0A5F8GUI9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">RNA binding protein fox-1 homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RBFOX1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">RNA-binding protein that regulates alternative splicing events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to the C-terminus of ATXN2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056660055.1">
        <property type="nucleotide sequence ID" value="XM_056804077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUI9"/>
    <dbReference type="Ensembl" id="ENSMODT00000088952.1">
        <property type="protein sequence ID" value="ENSMODP00000051167.1"/>
        <property type="gene ID" value="ENSMODG00000005826.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100018811"/>
    <dbReference type="CTD" id="54715"/>
    <dbReference type="GeneTree" id="ENSGT00940000160685"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005826">
        <property type="expression patterns" value="Expressed in cerebellum and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12407">
        <property type="entry name" value="RRM_FOX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000375">
        <property type="entry name" value="RNA binding fox-1 homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025670">
        <property type="entry name" value="Fox-1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034237">
        <property type="entry name" value="FOX1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017325">
        <property type="entry name" value="RBFOX1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047131">
        <property type="entry name" value="RBFOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597">
        <property type="entry name" value="ATAXIN 2-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597:SF45">
        <property type="entry name" value="RNA BINDING PROTEIN FOX-1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12414">
        <property type="entry name" value="Fox-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037932">
        <property type="entry name" value="Ataxin_2_bd_A2BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="117"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="11">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="11">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="11">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="11">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="11">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="11">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="11">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="11">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037932-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="370" mass="40051" checksum="E8DD245C0B31D790" modified="2019-12-11" version="1">MNCERDQLRGNQEATAAPDTMAQPYASAQFAPPQNGIPAEYTAPHPHPAPEYTGQTTVPEHTLNMYPPAQTHSEQSATDTSAQTVSGTATQTDDAAQTDGQPQTQPSENTENKSQPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKTVNPYTNGWKLNPVVGAVYSPEFYAVPGFPYPAATAAAAYRGAHLRGRGRTVYNTFRAAAPPPPIPAYGGVVYQDGFYGADIYGGYAAYRYAQPATATAAAYSDSYGRVYAADPYHHTLAPAPTYGVGAMNAFAPLTDAKTRSHADDVGLVLSSLQASIYRGGYSRFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUJ1</accession>
    <name>A0A5F8GUJ1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SLC6A2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUJ1"/>
    <dbReference type="Ensembl" id="ENSMODT00000072475.1">
        <property type="protein sequence ID" value="ENSMODP00000050881.1"/>
        <property type="gene ID" value="ENSMODG00000013227.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158960"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013227">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008504">
        <property type="term" value="F:monoamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015378">
        <property type="term" value="F:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090493">
        <property type="term" value="P:catecholamine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF320">
        <property type="entry name" value="SODIUM-DEPENDENT NORADRENALINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 15" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="573" mass="64375" checksum="EF852B6F8BB6ABBD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUJ2</accession>
    <name>A0A5F8GUJ2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ELAV-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ELAVL4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 12">Belongs to the RRM elav family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007480259.1">
        <property type="nucleotide sequence ID" value="XM_007480197.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUJ2"/>
    <dbReference type="Ensembl" id="ENSMODT00000081880.1">
        <property type="protein sequence ID" value="ENSMODP00000051308.1"/>
        <property type="gene ID" value="ENSMODG00000001300.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021505"/>
    <dbReference type="CTD" id="1996"/>
    <dbReference type="GeneTree" id="ENSGT00940000157399"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001300">
        <property type="expression patterns" value="Expressed in brain and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12652">
        <property type="entry name" value="RRM2_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12656">
        <property type="entry name" value="RRM3_HuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000006">
        <property type="entry name" value="ELAV-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000005">
        <property type="entry name" value="ELAV-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000017">
        <property type="entry name" value="ELAV-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006548">
        <property type="entry name" value="ELAD_HU_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034918">
        <property type="entry name" value="HuD_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01661">
        <property type="entry name" value="ELAV_HUD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 12" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="59"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="145"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="296"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="379" mass="41793" checksum="383FDF6EAB6D96CD" modified="2019-12-11" version="1">MFEISRTLNAALLNTEIISTMEPQVSNGPASNTTNGPSSNGRNCPSPMQTGATTDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKTSQALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRFSPITIDGMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUJ5</accession>
    <name>A0A5F8GUJ5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CD209 molecule</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUJ5"/>
    <dbReference type="Ensembl" id="ENSMODT00000088714.1">
        <property type="protein sequence ID" value="ENSMODP00000051172.1"/>
        <property type="gene ID" value="ENSMODG00000014982.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160666"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014982">
        <property type="expression patterns" value="Expressed in liver and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052309">
        <property type="entry name" value="C-type_Lectin_Domain_Fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490:SF6">
        <property type="entry name" value="ASIALOGLYCOPROTEIN RECEPTOR 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="136"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="257" mass="29346" checksum="88EA03F12D02C103" modified="2019-12-11" version="1">MCDLVAPKSPEMSGLDEEELMPSGWSPFDLGTQRSQSPRSFPAPWLRRLGFPLLLAFFVLSFILSIITLTQVFQNQRLYNSEQEAVQEKLNYLSAQLKGDQDLRDKGQLEASQFIEQLNKTLSALCRPCPCQWKFYKDSCYYFSVAQASWETARKACEADGTNLAIISSSEEQNYLKLNLDSNRRPRWIGLSDKKKEGTWHWVDETALGQSFWNEGEPNNAGDEDCCELIPNGWNDAPCSKENYWICEKKASPCPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUJ6</accession>
    <name>A0A5F8GUJ6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Ecto-NOX disulfide-thiol exchanger 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ENOX2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ENOX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056665160.1">
        <property type="nucleotide sequence ID" value="XM_056809182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUJ6"/>
    <dbReference type="Ensembl" id="ENSMODT00000075582.1">
        <property type="protein sequence ID" value="ENSMODP00000051313.1"/>
        <property type="gene ID" value="ENSMODG00000015416.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022116"/>
    <dbReference type="CTD" id="10495"/>
    <dbReference type="GeneTree" id="ENSGT00390000006788"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015416">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007624">
        <property type="term" value="P:ultradian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12228">
        <property type="entry name" value="RRM_ENOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000083">
        <property type="entry name" value="Putative ecto-NOX disulfide-thiol exchanger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038876">
        <property type="entry name" value="ENOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056611">
        <property type="entry name" value="ENOX1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034140">
        <property type="entry name" value="ENOX_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001:SF7">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23267">
        <property type="entry name" value="ENOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="136"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="419"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="617" mass="70494" checksum="4C703E4BCAD34F7B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUJ7</accession>
    <name>A0A5F8GUJ7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrosomal protein 295</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000064939.1">
        <property type="protein sequence ID" value="ENSMODP00000050886.1"/>
        <property type="gene ID" value="ENSMODG00000000714.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153123"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000714">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21553:SF26">
        <property type="entry name" value="ALMS MOTIF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21553">
        <property type="entry name" value="ALMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1287"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1381"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1552"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1654"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1792"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1919"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2108"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="697"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1450"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1287"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1558"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1655"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1798"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1926"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1952"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1963"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2128"/>
            <end position="2138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2268" mass="260363" checksum="D1C63DABA0670606" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUJ8</accession>
    <name>A0A5F8GUJ8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Neuronal cell adhesion molecule</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Neuronal surface protein Bravo</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NgCAM-related cell adhesion molecule</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">NRCAM</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUJ8"/>
    <dbReference type="Ensembl" id="ENSMODT00000062461.1">
        <property type="protein sequence ID" value="ENSMODP00000051024.1"/>
        <property type="gene ID" value="ENSMODG00000016040.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155419"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016040">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd05868">
        <property type="entry name" value="Ig4_NrCAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000057">
        <property type="entry name" value="neural cell adhesion molecule L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000363">
        <property type="entry name" value="neurofascin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000038">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000078">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000114">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000238">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000347">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000100">
        <property type="entry name" value="Neuronal cell adhesion molecule a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000332">
        <property type="entry name" value="neuronal cell adhesion molecule isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026966">
        <property type="entry name" value="Neurofascin/L1/NrCAM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF257">
        <property type="entry name" value="NEURAL CELL ADHESION MOLECULE L1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13882">
        <property type="entry name" value="Bravo_FIGEY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023907095" description="Neuronal cell adhesion molecule" evidence="19">
        <location>
            <begin position="30"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1064"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="135"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="262"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="355"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="448"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="539"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="637"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="734"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="836"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="942"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1094"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1094"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1121"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1140"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1187"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1203" mass="133861" checksum="586B1B60A9009289" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUJ9</accession>
    <name>A0A5F8GUJ9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Slit homolog 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SLIT2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000062685.1">
        <property type="protein sequence ID" value="ENSMODP00000051177.1"/>
        <property type="gene ID" value="ENSMODG00000000731.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158402"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000731">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072359">
        <property type="term" value="P:circulatory system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060560">
        <property type="term" value="P:developmental growth involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060562">
        <property type="term" value="P:epithelial tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050919">
        <property type="term" value="P:negative chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021772">
        <property type="term" value="P:olfactory bulb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050770">
        <property type="term" value="P:regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032535">
        <property type="term" value="P:regulation of cellular component size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031290">
        <property type="term" value="P:retinal ganglion cell axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022029">
        <property type="term" value="P:telencephalon cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000045">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000053">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000054">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000062">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000063">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000099">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000289">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000013">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000004">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000376">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000032">
        <property type="entry name" value="Slit homolog 2 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051355">
        <property type="entry name" value="Notch/Slit_guidance"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836">
        <property type="entry name" value="SLIT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836:SF2">
        <property type="entry name" value="SLIT HOMOLOG 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023810651" description="Slit homolog 2 protein" evidence="16">
        <location>
            <begin position="26"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="916"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="953"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="994"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1041"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1081"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1126"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="1165"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1342"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1376"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1417"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="17">
        <location>
            <begin position="1458"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1152"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1363"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1380"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1402"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1421"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1443"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1534" mass="170331" checksum="B843B96BBE74C2D7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUK2</accession>
    <name>A0A5F8GUK2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Janus kinase and microtubule interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">JAKMIP2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the JAKMIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUK2"/>
    <dbReference type="Ensembl" id="ENSMODT00000063101.1">
        <property type="protein sequence ID" value="ENSMODP00000051182.1"/>
        <property type="gene ID" value="ENSMODG00000005857.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153713"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005857">
        <property type="expression patterns" value="Expressed in spinal cord and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024836">
        <property type="entry name" value="JAKMIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031994">
        <property type="entry name" value="JAKMIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18935">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18935:SF7">
        <property type="entry name" value="JANUS KINASE AND MICROTUBULE-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16034">
        <property type="entry name" value="JAKMIP_CC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Janus kinase and microtubule-interacting protein C-terminal" evidence="5">
        <location>
            <begin position="409"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="281"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="471"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="667"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="794" mass="92725" checksum="FDD2901951E33496" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUK3</accession>
    <name>A0A5F8GUK3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deleted in lymphocytic leukemia 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DLEU7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007495465.1">
        <property type="nucleotide sequence ID" value="XM_007495403.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUK3"/>
    <dbReference type="Ensembl" id="ENSMODT00000072836.1">
        <property type="protein sequence ID" value="ENSMODP00000051225.1"/>
        <property type="gene ID" value="ENSMODG00000010784.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100028362"/>
    <dbReference type="CTD" id="220107"/>
    <dbReference type="GeneTree" id="ENSGT00390000011737"/>
    <dbReference type="OrthoDB" id="8788044at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010784">
        <property type="expression patterns" value="Expressed in ovary and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031510">
        <property type="entry name" value="DLEU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36961">
        <property type="entry name" value="LEUKEMIA-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36961:SF1">
        <property type="entry name" value="LEUKEMIA-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15760">
        <property type="entry name" value="DLEU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="160" mass="17439" checksum="109D712AD6EC6FF5" modified="2019-12-11" version="1">MANTAHLLASINHQIVALQTLRLLQQQRDREEGQLFSSLVSEAPGQAGQREEKEGGGGPAAGTAGDELGAVPEPRDSGQCELARLAVRTVLARVVESTSQLVRVEQTILSPLHQELNFPIHMKASIHLWASFLHQLWSLASTFTANVLHVEIQTTDNKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUK7</accession>
    <name>A0A5F8GUK7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myocyte enhancer factor 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MEF2A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056663238.1">
        <property type="nucleotide sequence ID" value="XM_056807260.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056663249.1">
        <property type="nucleotide sequence ID" value="XM_056807271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUK7"/>
    <dbReference type="Ensembl" id="ENSMODT00000078623.1">
        <property type="protein sequence ID" value="ENSMODP00000051187.1"/>
        <property type="gene ID" value="ENSMODG00000012725.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100020349"/>
    <dbReference type="CTD" id="4205"/>
    <dbReference type="GeneTree" id="ENSGT00940000156205"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012725">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022102">
        <property type="entry name" value="HJURP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12347">
        <property type="entry name" value="HJURP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="368"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="483" mass="52832" checksum="FDF8E3D39C655620" modified="2019-12-11" version="1">MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDADDYFEHSPLSEDRFSKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTNHNALTYTNPGSSLVSPSLAASSSLTDTSMLSPPQATMLRNVSPGAPQRPPSTGNTGNGFVNSRASPNLLVSTGGSNLGKVMPTKSPPPPGNGNLGMNNRKPDLRVVIPPSSKGMMPPLSEEDELELNSQRISSSQSTQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNINIKSEPISPPRDRMTPSGFPQQQQQQQQQQQQQQQQQQQQQQQARQEMGRSPVDSLSSSSSSYDGSDREDPRSDFHSPIGLGRPPNTEDRESPSVKRMRMDTWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUK9</accession>
    <name>A0A5F8GUK9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TUBB4B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUK9"/>
    <dbReference type="STRING" id="13616.ENSMODP00000050896"/>
    <dbReference type="Ensembl" id="ENSMODT00000073751.1">
        <property type="protein sequence ID" value="ENSMODP00000050896.1"/>
        <property type="gene ID" value="ENSMODG00000017213.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154394"/>
    <dbReference type="InParanoid" id="A0A5F8GUK9"/>
    <dbReference type="OMA" id="MFFVEWI"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017213">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="85"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="284"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="483" mass="53488" checksum="D317080F2F6D296F" modified="2019-12-11" version="1">MREGGLGRTGRGLGLGRPPGAWPAPPCAAPHCTGCTAKPALGDSGLSLLDRPANVFQFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUL0</accession>
    <name>A0A5F8GUL0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Synaptonemal complex protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SYCP2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUL0"/>
    <dbReference type="Ensembl" id="ENSMODT00000062740.1">
        <property type="protein sequence ID" value="ENSMODP00000051323.1"/>
        <property type="gene ID" value="ENSMODG00000016617.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063859"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016617">
        <property type="expression patterns" value="Expressed in testis and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024835">
        <property type="entry name" value="SYCP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041322">
        <property type="entry name" value="SYCP2_ARLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040560">
        <property type="entry name" value="SYCP2_SLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15607:SF12">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15607">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18581">
        <property type="entry name" value="SYCP2_ARLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18584">
        <property type="entry name" value="SYCP2_SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Synaptonemal complex protein 2 armadillo-repeat-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Synaptonemal complex protein 2 Spt16M-like" evidence="8">
        <location>
            <begin position="154"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="41146" checksum="6667FBAD0849B425" modified="2019-12-11" version="1">MVAWFEKIKEIILSHKNEKDEAMMNLIEDFFDVLMTVHDINNEGKMEVLEDFILRICALVVDMRIHICIRQEAIKKLNALLDNISRDARKIISKPEMLSLIMTSEKQRRELACQWFSMEFVANAFKGIKDSDFETDCRKFLNHVNGMLGDKRLVFTFPCLSVFLDKCELQIPSDEKLDEFWIDFNLGSQSISFYIAGDDDDHQWETVSIPNDEVEAFSVEVKDAKKLLTLILKNTMNVGNKVGGQLLLYFDPSLEIIDVTKNIYGANKHRGFTRKQASSVAKTAVHIIFDESGSQVLFIVKPPLKMVNSAEPPSVYKVKERGAKNAVSLPGSVEGRNPHSYQNGDVDIIPDSQPVGKRDKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUL5</accession>
    <name>A0A5F8GUL5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endothelial differentiation-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EDF1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUL5"/>
    <dbReference type="FunCoup" id="A0A5F8GUL5">
        <property type="interactions" value="2222"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051328"/>
    <dbReference type="Ensembl" id="ENSMODT00000058123.1">
        <property type="protein sequence ID" value="ENSMODP00000051328.1"/>
        <property type="gene ID" value="ENSMODG00000017329.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008519"/>
    <dbReference type="InParanoid" id="A0A5F8GUL5"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017329">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001094">
        <property type="term" value="F:TFIID-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000015">
        <property type="entry name" value="Endothelial differentiation-related factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="166" mass="18622" checksum="B5538A5E2198A58A" modified="2019-12-11" version="1">MVKRVSFCPHWSPRKNLLTVQFHIVNINISIWRTVKSDSPFGKSFLYVRFQSSLPSLILCIGAAGQNKQHSITKNTAKLDRETEELHHDRVTLEVGKVIQQGRQSKGLTQKDLATKINEKPQVIADYECGRAIPNNQVLGKIERAIGLKLRGKDIGKPLETGPKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUL6</accession>
    <name>A0A5F8GUL6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endoplasmic reticulum resident protein 44</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ERP44</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms mixed disulfides with both ERO1A and ERO1B and cargo folding intermediates; the interactions with ERO1A and ERO1B result in their retention in the endoplasmic reticulum. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUL6"/>
    <dbReference type="FunCoup" id="A0A5F8GUL6">
        <property type="interactions" value="2109"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051044"/>
    <dbReference type="Ensembl" id="ENSMODT00000057292.1">
        <property type="protein sequence ID" value="ENSMODP00000051044.1"/>
        <property type="gene ID" value="ENSMODG00000012640.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151031"/>
    <dbReference type="InParanoid" id="A0A5F8GUL6"/>
    <dbReference type="OMA" id="DWCRFSN"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012640">
        <property type="expression patterns" value="Expressed in endometrium and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02996">
        <property type="entry name" value="PDI_a_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03072">
        <property type="entry name" value="PDI_b'_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03070">
        <property type="entry name" value="PDI_b_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000051">
        <property type="entry name" value="endoplasmic reticulum resident protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000074">
        <property type="entry name" value="endoplasmic reticulum resident protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000128">
        <property type="entry name" value="endoplasmic reticulum resident protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041870">
        <property type="entry name" value="ERp44_PDI_b_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041862">
        <property type="entry name" value="ERp44_PDI_b_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF1">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="414" mass="48076" checksum="6F5EF34AC1F50830" modified="2019-12-11" version="1">MMWNGSIGRYPRDRRVHFGFQPCANNEITWIFTPITAEIASLDSGNIDEILNNADVALVNFYADWCRFSQMLHPIFEEASNVIKEEYPNKNQVVFARVDCDQHSEIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVTAIADYIRQQKSDPIQEVHDLEEIKFLDRSKRTIIGYFEQKDSDNYRTFERVANILHDDCVFFSAFGSVSKPERFSGDNVIYRPPGENAPDMVYLGSLTNFDLVYAWTQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTVSLDVFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFPDFTDLSIPNKLKQFVLDLHSGKLHREFHHGPDPTDVAPGQHIQDVASSPPESSFQKLAPSEYRYTLLRDRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUM1</accession>
    <name>A0A5F8GUM1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Xaa-Pro aminopeptidase 3</fullName>
            <ecNumber evidence="6">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aminopeptidase P3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">XPNPEP3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="6"/>
    <dbReference type="RefSeq" id="XP_016281032.1">
        <property type="nucleotide sequence ID" value="XM_016425546.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUM1"/>
    <dbReference type="Ensembl" id="ENSMODT00000068731.1">
        <property type="protein sequence ID" value="ENSMODP00000051049.1"/>
        <property type="gene ID" value="ENSMODG00000013052.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100027935"/>
    <dbReference type="CTD" id="63929"/>
    <dbReference type="GeneTree" id="ENSGT00940000153657"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013052">
        <property type="expression patterns" value="Expressed in spermatocyte and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000013">
        <property type="entry name" value="probable Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="15">
        <location>
            <begin position="67"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="486" mass="54439" checksum="31D8A30789FDB4F4" modified="2019-12-11" version="1">MPWLLLAPRLGPVARSARGLAGCTSCLQRRFSLQPIPERKMPSRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHRLMALIQKEAQGKGGTDQAVILLSNPTFYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPDKELPAHKAVLFVPRRDPSRELWDGPRSGADGAVALTGVDEAFPLEEFKHLLPKLTAETSTVWYDWNKPSHSQLHCDYMHPLTEAKARSKNRVRTVQHLVQHLRLIKSPAEIALLQGAGRLTSQFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQIIKDGEMVLLDGGCEFSGYVSDITRTWPVNGRFSAAQAELYEAVLDIQKACLALCCPGTSLENIYNLMLNLIGQKLQELRVLTRLRADNIFKAARKYCPHHVGHYLGMDVHDTPDVSRSLPLQPGMVVTIEPGIYISEDDRDACERFRGLGVRIEDDVLVTQDSPLILSADCPKELRHIEQICDRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUM2</accession>
    <name>A0A5F8GUM2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CD209 molecule</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUM2"/>
    <dbReference type="Ensembl" id="ENSMODT00000077430.1">
        <property type="protein sequence ID" value="ENSMODP00000051245.1"/>
        <property type="gene ID" value="ENSMODG00000014982.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160666"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014982">
        <property type="expression patterns" value="Expressed in liver and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="208"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="328" mass="37473" checksum="55D8D64ECC8ADBD4" modified="2019-12-11" version="1">MCDLVAPKSPEMSGLDEEELMPSGWSPFDLGTQRSQSPRSFPAPWLRRLGFPLLLAFFVLSFILSIITLTQVFQNQRQYNSEQEVVQEKLKNLSDKLKGDQDLKAKDQPEASLFIQQLNKTLNLRAKDQLEASQLIEQLNKTLTLRAKDQLEASQFIEELNKASQFIEELNKASQVIEQLSKASQFIEQLNKTLSTLCRPCPYEWKFYKDSCYYFSVTRKPWEASQNTCEADGSNLGIISSSEEQNYLKKNAASNHQLWVGLSDKKKEGYWHWVDGTALGQSFWNEGEPNNAGDEDCCELIPNGWNDAPCSKENYWICEKKASPCPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUM4</accession>
    <name>A0A5F8GUM4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CAMK2G</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUM4"/>
    <dbReference type="Ensembl" id="ENSMODT00000077043.1">
        <property type="protein sequence ID" value="ENSMODP00000050911.1"/>
        <property type="gene ID" value="ENSMODG00000000536.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156481"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000536">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14086">
        <property type="entry name" value="STKc_CaMKII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000001">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000002">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000001">
        <property type="entry name" value="calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="14"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="344"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="614" mass="68112" checksum="D53B83E37818AF7A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUM6</accession>
    <name>A0A5F8GUM6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase cytochrome b560 subunit, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Malate dehydrogenase [quinone] cytochrome b560 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SDHC</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b560 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUM6"/>
    <dbReference type="Ensembl" id="ENSMODT00000053548.1">
        <property type="protein sequence ID" value="ENSMODP00000051338.1"/>
        <property type="gene ID" value="ENSMODG00000005031.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000566"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005031">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000006">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.540:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.540">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="187" mass="20339" checksum="287F52CF2CDE4796" modified="2019-12-11" version="1">MPKSSRLWQNLPQLGSSSSSLTLTQYAGRPCLRAHLSPRLCIRNAVPLGTTAKEEMEHFWNKNTNSNRPLSPHITIYSWSLPMAMSICHRASGIALSAGVSLFGLAALLLPGNFESHVELLKSLSLGPALIHTAKFALVSPLMYHTWNGIRHLTWDLGMGLKIPQLYQSGVVVLALTVLSSIGLAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUM7</accession>
    <name>A0A5F8GUM7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dedicator of cytokinesis 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DOCK11</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000088810.1">
        <property type="protein sequence ID" value="ENSMODP00000051250.1"/>
        <property type="gene ID" value="ENSMODG00000011503.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155658"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011503">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08697">
        <property type="entry name" value="C2_Dock-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11700">
        <property type="entry name" value="DHR2_DOCK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13267">
        <property type="entry name" value="PH_DOCK-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000016">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037809">
        <property type="entry name" value="C2_Dock-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF81">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="201"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="645"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1471"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1932" mass="221215" checksum="7A3001CAEC84F6F3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUM9</accession>
    <name>A0A5F8GUM9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thymocyte selection associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">THEMIS</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the themis family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007484591.1">
        <property type="nucleotide sequence ID" value="XM_007484529.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUM9"/>
    <dbReference type="Ensembl" id="ENSMODT00000057574.1">
        <property type="protein sequence ID" value="ENSMODP00000051207.1"/>
        <property type="gene ID" value="ENSMODG00000017668.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100030867"/>
    <dbReference type="CTD" id="387357"/>
    <dbReference type="GeneTree" id="ENSGT00530000063770"/>
    <dbReference type="OrthoDB" id="9879477at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017668">
        <property type="expression patterns" value="Expressed in spermatocyte and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039671">
        <property type="entry name" value="THEMIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15215">
        <property type="entry name" value="CABIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15215:SF1">
        <property type="entry name" value="PROTEIN THEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="3">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CABIT" evidence="3">
        <location>
            <begin position="281"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="599" mass="68427" checksum="382D5AF330AFC50D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUN2</accession>
    <name>A0A5F8GUN2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUN2"/>
    <dbReference type="Ensembl" id="ENSMODT00000072559.1">
        <property type="protein sequence ID" value="ENSMODP00000051064.1"/>
        <property type="gene ID" value="ENSMODG00000007426.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158256"/>
    <dbReference type="OMA" id="WITPRIS"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007426">
        <property type="expression patterns" value="Expressed in lung and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd09497">
        <property type="entry name" value="SAM_caskin1_2_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09498">
        <property type="entry name" value="SAM_caskin1_2_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000032">
        <property type="entry name" value="caskin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000028">
        <property type="entry name" value="caskin-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035497">
        <property type="entry name" value="Caskin1/2_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035498">
        <property type="entry name" value="Caskin1/2_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF18">
        <property type="entry name" value="CASKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16907">
        <property type="entry name" value="Caskin-Pro-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="74"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="679" mass="70727" checksum="0A0B8433F41AF287" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUN9</accession>
    <name>A0A5F8GUN9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fas associated factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAF1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_056671147.1">
        <property type="nucleotide sequence ID" value="XM_056815169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUN9"/>
    <dbReference type="Ensembl" id="ENSMODT00000054234.1">
        <property type="protein sequence ID" value="ENSMODP00000050926.1"/>
        <property type="gene ID" value="ENSMODG00000001243.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021009"/>
    <dbReference type="CTD" id="11124"/>
    <dbReference type="GeneTree" id="ENSGT00940000154831"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001243">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd02990">
        <property type="entry name" value="UAS_FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14413">
        <property type="entry name" value="UBA_FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17129">
        <property type="entry name" value="Ubl1_FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17056">
        <property type="entry name" value="Ubl_FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01771">
        <property type="entry name" value="UBX_UBXN3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000089">
        <property type="entry name" value="Fas associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000122">
        <property type="entry name" value="Fas associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000137">
        <property type="entry name" value="Fas associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000061">
        <property type="entry name" value="Fas associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033043">
        <property type="entry name" value="FAF1-like_UBX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044541">
        <property type="entry name" value="FAF1_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF96">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="555"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="636" mass="72026" checksum="D3591D00E4486933" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6I9</accession>
    <name>A0A5F8H6I9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Dual specificity mitogen-activated protein kinase kinase 2</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
            <ecNumber evidence="14">2.7.12.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ERK activator kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">MAPK/ERK kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">MAP2K2</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43637"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="1"/>
    <dbReference type="EC" id="2.7.12.2" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6I9"/>
    <dbReference type="FunCoup" id="A0A5F8H6I9">
        <property type="interactions" value="1939"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055553"/>
    <dbReference type="Ensembl" id="ENSMODT00000063288.1">
        <property type="protein sequence ID" value="ENSMODP00000055553.1"/>
        <property type="gene ID" value="ENSMODG00000000809.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153487"/>
    <dbReference type="InParanoid" id="A0A5F8H6I9"/>
    <dbReference type="OMA" id="WVINCEV"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000809">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141050">
        <property type="term" value="F:histone H3K deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060502">
        <property type="term" value="P:epithelial cell proliferation involved in lung morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038133">
        <property type="term" value="P:ERBB2-ERBB3 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060324">
        <property type="term" value="P:face development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048009">
        <property type="term" value="P:insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000147">
        <property type="term" value="P:positive regulation of cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048679">
        <property type="term" value="P:regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090170">
        <property type="term" value="P:regulation of Golgi inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032872">
        <property type="term" value="P:regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014044">
        <property type="term" value="P:Schwann cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030878">
        <property type="term" value="P:thyroid gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060440">
        <property type="term" value="P:trachea formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06649">
        <property type="entry name" value="PKc_MEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000115">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000100">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.200:FF:000001">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF3">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="8 22" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="27">
        <location>
            <begin position="27"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="219"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="22">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="547" mass="60868" checksum="9E1E32A2486DDBE4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6J1</accession>
    <name>A0A5F8H6J1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CTPS2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6J1"/>
    <dbReference type="Ensembl" id="ENSMODT00000066455.1">
        <property type="protein sequence ID" value="ENSMODP00000055600.1"/>
        <property type="gene ID" value="ENSMODG00000017176.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000144179"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017176">
        <property type="expression patterns" value="Expressed in lung and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF2">
        <property type="entry name" value="CTP SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="10"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="163" mass="18675" checksum="893877BB0E8799BE" modified="2019-12-11" version="1">MEEVIDMPEHHPGEMGGTMRLGKRTTVFKTEDSILRKLYGDVGCVEERHRHRYEVNPELIQQFEEKGLKFVGRDIEGERMEIIELANHPYFVAVQFHPEFSSRPMKPSPPYLGLLLAATGTLNAYLQQGCKLSSRGTFRKNDSYSDLSDDSFPERKSPEIVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6J5</accession>
    <name>A0A5F8H6J5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G protein-coupled receptor class C group 5 member C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GPRC5C</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6J5"/>
    <dbReference type="FunCoup" id="A0A5F8H6J5">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055605"/>
    <dbReference type="Ensembl" id="ENSMODT00000080738.1">
        <property type="protein sequence ID" value="ENSMODP00000055605.1"/>
        <property type="gene ID" value="ENSMODG00000006818.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182961"/>
    <dbReference type="InParanoid" id="A0A5F8H6J5"/>
    <dbReference type="OMA" id="FDMVIPR"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006818">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd15277">
        <property type="entry name" value="7tmC_RAIG3_GPRC5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051753">
        <property type="entry name" value="RA-inducible_GPCR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14511">
        <property type="entry name" value="G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14511:SF15">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="9">
        <location>
            <begin position="149"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="500" mass="54642" checksum="8A2F1D87829766DF" modified="2019-12-11" version="1">MFQQLSPDTAAEARREEDGSGLSNRAKQLLEQLEQDTLQTPSGFFWDPVWTGSRARMAIPQALLSCLGVLLLLLPRNQAQVHAPPGCSPDLNPLYYNLCDRSGAWGIVLEALAGAGVISTFVLTIILVASLPFVQDSKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDFSTCASRRFLFGVLFGICFSCLSAHVFALNFLARKNQGPRGWVIFAVALLLALVEVIINTEWLIITLVRGGHGGGGVLHGNSSTSWGEASPCAIANMDFVMALIYVMLLLLTAFVGAWPILCGRFKRWRKHGVFVLLTTATSIAIWVVWIVMYTYGNEQRNSPTWDDPTLAIALAANAWAFVLFYIIPEVSQVTKASPEQSYQGDIYPTRGVGYETILKEKGQSMFVENKAFSMDEPSSAKRPVSPYSGYNGQLLTSVYQPTEMALMHKGLSEGPYDVILPRATANSSQVMGSANSTLRAEDVYATQSHQAASQKDVKNAQAMQDPTPFQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6J8</accession>
    <name>A0A5F8H6J8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">KIAA0825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">KIAA0825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007487356.1">
        <property type="nucleotide sequence ID" value="XM_007487294.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6J8"/>
    <dbReference type="Ensembl" id="ENSMODT00000071325.1">
        <property type="protein sequence ID" value="ENSMODP00000055184.1"/>
        <property type="gene ID" value="ENSMODG00000020128.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100011543"/>
    <dbReference type="CTD" id="285600"/>
    <dbReference type="GeneTree" id="ENSGT00610000086112"/>
    <dbReference type="OrthoDB" id="10007406at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020128">
        <property type="expression patterns" value="Expressed in spermatocyte and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027993">
        <property type="entry name" value="DUF4495"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960:SF1">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14906">
        <property type="entry name" value="DUF4495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1261" mass="145066" checksum="58FFC71E3C4FB40C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6K0</accession>
    <name>A0A5F8H6K0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6K0"/>
    <dbReference type="Ensembl" id="ENSMODT00000055655.1">
        <property type="protein sequence ID" value="ENSMODP00000055610.1"/>
        <property type="gene ID" value="ENSMODG00000023262.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182886"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023262">
        <property type="expression patterns" value="Expressed in ovary and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF59">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="217" mass="25284" checksum="DAEDDB9047BE4A42" modified="2019-12-11" version="1">MVFLIEYAGSLFIYLLFYLRMPFVYGLEKKLMSRRLPVVNLACICHSSHYIKRLIETIFVHRFSHGTMPLKSIVKNCFFYWGFAAWLAYYINHPLYTPPSYGQKQINFSLITFLLCEAGNFSIHVELNNLRGNGPKTRRIPYPTKNPFTWLFFFVSCPNYTYEVGAWISFTIMTQCVPVGLFTLVGFIQMTIWAKDKHCTYPKQGVVAFLSMETPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6K2</accession>
    <name>A0A5F8H6K2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase C-binding protein NELL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">NEL-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">NELL1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056658002.1">
        <property type="nucleotide sequence ID" value="XM_056802024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6K2"/>
    <dbReference type="Ensembl" id="ENSMODT00000083217.1">
        <property type="protein sequence ID" value="ENSMODP00000055417.1"/>
        <property type="gene ID" value="ENSMODG00000009237.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100030574"/>
    <dbReference type="CTD" id="4745"/>
    <dbReference type="GeneTree" id="ENSGT00810000125439"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009237">
        <property type="expression patterns" value="Expressed in spinal cord and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045778">
        <property type="term" value="P:positive regulation of ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045667">
        <property type="term" value="P:regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000121">
        <property type="entry name" value="Neural EGFL like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000120">
        <property type="entry name" value="Protein kinase C-binding protein NELL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000211">
        <property type="entry name" value="Protein kinase C-binding protein NELL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000221">
        <property type="entry name" value="Protein kinase C-binding protein NELL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000015">
        <property type="entry name" value="protein kinase C-binding protein NELL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000102">
        <property type="entry name" value="Protein kinase C-binding protein NELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000111">
        <property type="entry name" value="Protein kinase C-binding protein NELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000023">
        <property type="entry name" value="protein kinase C-binding protein NELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051586">
        <property type="entry name" value="PKC-binding_NELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042">
        <property type="entry name" value="NEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042:SF2">
        <property type="entry name" value="PROTEIN KINASE C-BINDING PROTEIN NELL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="20">
        <location>
            <begin position="214"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="419"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="492"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="539"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="20">
        <location>
            <begin position="575"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="20">
        <location>
            <begin position="635"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="753" mass="83419" checksum="6DD66FFE540BBD83" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6K3</accession>
    <name>A0A5F8H6K3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MAP4K5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6K3"/>
    <dbReference type="Ensembl" id="ENSMODT00000083981.1">
        <property type="protein sequence ID" value="ENSMODP00000055615.1"/>
        <property type="gene ID" value="ENSMODG00000011778.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158072"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011778">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000031">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021160">
        <property type="entry name" value="MAPKKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF19">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038172">
        <property type="entry name" value="MAPKKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="14">
        <location>
            <begin position="345"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="26"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="669" mass="75801" checksum="8A868E2B5BDD94AB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6K6</accession>
    <name>A0A5F8H6K6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endophilin-B1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">SH3 domain-containing GRB2-like protein B1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SH3GLB1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6K6"/>
    <dbReference type="Ensembl" id="ENSMODT00000062916.1">
        <property type="protein sequence ID" value="ENSMODP00000054861.1"/>
        <property type="gene ID" value="ENSMODG00000008125.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155667"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008125">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11945">
        <property type="entry name" value="SH3_Endophilin_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000017">
        <property type="entry name" value="endophilin-B2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000028">
        <property type="entry name" value="endophilin-B2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028503">
        <property type="entry name" value="SH3GLB_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF52">
        <property type="entry name" value="ENDOPHILIN-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="16">
        <location>
            <begin position="27"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="394" mass="44223" checksum="0002242610329E30" modified="2019-12-11" version="1">MSIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKQWTEKMMRQTEVLLQPNPNARIEEFVYEKLDRKAPTRINNQELLGQYMIDAGNDFGPGTAYGNALIKCGETQKRIGTADRELVQTAAINFLTPLRNFIEGDYKTITKERKLLQNKRLDLDAAKTRLKKAKIAETRALQLNSTQPEGDNIMVNLSYMLNLLHVKWLKSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSVFVSNNSQSSTTSMSNISTSSSGITTSLLPSTSGTAITPAIGDLKESSGNRKARVLYDYDAANSTELSLLADEVITVYSIVGMDSDWLMGERGNQKGKVPITYLELLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6K7</accession>
    <name>A0A5F8H6K7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ATP2B2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6K7"/>
    <dbReference type="Ensembl" id="ENSMODT00000063707.1">
        <property type="protein sequence ID" value="ENSMODP00000055422.1"/>
        <property type="gene ID" value="ENSMODG00000005537.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161461"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005537">
        <property type="expression patterns" value="Expressed in cerebellum and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF377">
        <property type="entry name" value="PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="601" mass="66058" checksum="136A8BE3B6CAFC6E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6L0</accession>
    <name>A0A5F8H6L0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Caspase-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CASP16</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6L0"/>
    <dbReference type="Ensembl" id="ENSMODT00000075696.1">
        <property type="protein sequence ID" value="ENSMODP00000055620.1"/>
        <property type="gene ID" value="ENSMODG00000016461.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163674"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016461">
        <property type="expression patterns" value="Expressed in liver and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000067">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF41">
        <property type="entry name" value="CASPASE 14, APOPTOSIS-RELATED CYSTEINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="4">
        <location>
            <begin position="242"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="3">
        <location>
            <begin position="353"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="447" mass="49613" checksum="B04BD369FDCE5AC0" modified="2019-12-11" version="1">MSFLAAGSLQVAVEKAEGRVCLEKKGDYDTSGARVALTLCATEGQAGEDRIIAALEAMYQVMSCKSYLRRVVKAQSFQEEMASFRENLDDRGSSMNCALVALVAHSERPGWLLGPDGKEVQEKELVRELNHCQALWGKAKVFLLLDIHNNLGSIAFLSTLTDVCRHFPHWHLLEVLTQVIGKVTQEMPPTGHRCPIFQSSLRGALYLGRRRSQGLELSPIPQGVYDTSGAKVALVLCVTRDRPGAKQDLKALKRLFQTLGFKSILKMNPTAQDFRKELTRFRELLDARRTNVSCALVALMAHGEPQGRLLGADGQMVEVEEMVSELSACQVLQGKAKVVLLQGCRGDVSSKGYSPKNPDQVDILRVYSAAEGYVAYRNENGSDFIQTLVQVIIANPDQDLLELLTEVNKRLCEMEVRGPDCDEIRKMSVEIQSSLRKQLYLKSQLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6L1</accession>
    <name>A0A5F8H6L1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sialic acid binding Ig like lectin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SIGLEC1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000076490.1">
        <property type="protein sequence ID" value="ENSMODP00000054866.1"/>
        <property type="gene ID" value="ENSMODG00000011441.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286907"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011441">
        <property type="expression patterns" value="Expressed in liver and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000921">
        <property type="entry name" value="sialoadhesin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47243">
        <property type="entry name" value="SIALOADHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47243:SF1">
        <property type="entry name" value="SIALOADHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1486"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="92"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="179"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="266"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="362"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="452"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="551"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="641"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="737"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="828"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="921"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1011"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1107"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1193"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1291"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1382"/>
            <end position="1474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1512" mass="162537" checksum="DB73A78F59C5A0D7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6L3</accession>
    <name>A0A5F8H6L3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KIFAP3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6L3"/>
    <dbReference type="Ensembl" id="ENSMODT00000070540.1">
        <property type="protein sequence ID" value="ENSMODP00000055427.1"/>
        <property type="gene ID" value="ENSMODG00000003544.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003574"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003544">
        <property type="expression patterns" value="Expressed in spermatid and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008658">
        <property type="entry name" value="KAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605:SF2">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05804">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01297">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="545"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="749" mass="86406" checksum="0ABF8CD46B54472B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6L4</accession>
    <name>A0A5F8H6L4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6L4"/>
    <dbReference type="Ensembl" id="ENSMODT00000080091.1">
        <property type="protein sequence ID" value="ENSMODP00000055578.1"/>
        <property type="gene ID" value="ENSMODG00000042170.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000042170">
        <property type="expression patterns" value="Expressed in spermatid and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="100"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="189"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="276"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="365"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="452"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="517" mass="56472" checksum="5D32CDF9D9ACF18B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6L5</accession>
    <name>A0A5F8H6L5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho guanine nucleotide exchange factor 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6L5"/>
    <dbReference type="Ensembl" id="ENSMODT00000079752.1">
        <property type="protein sequence ID" value="ENSMODP00000055625.1"/>
        <property type="gene ID" value="ENSMODG00000018631.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100025913"/>
    <dbReference type="KEGG" id="mdo:100025913"/>
    <dbReference type="CTD" id="50649"/>
    <dbReference type="GeneTree" id="ENSGT00940000160622"/>
    <dbReference type="OMA" id="ACMRTQQ"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018631">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01224">
        <property type="entry name" value="PH_Collybistin_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11973">
        <property type="entry name" value="SH3_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000002">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000015">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="291"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="506"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="699" mass="78355" checksum="B6D44C9CCC502FD7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6L6</accession>
    <name>A0A5F8H6L6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Eukaryotic translation initiation factor 4E type 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Eukaryotic translation initiation factor 4E-like 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">eIF4E-like protein 4E-LP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">EIF4E2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression. Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3. Does not interact with eIF4G (EIF4G1, EIF4G2 or EIF4G3). Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598. Interacts with GIGYF2 (via the 4EHP-binding motif); the interaction is direct. Interacts with EIF4ENIF1/4E-T (via YXXXXLphi motif); increasing affinity for the 7-methylguanosine-containing mRNA cap.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056675905.1">
        <property type="nucleotide sequence ID" value="XM_056819927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6L6"/>
    <dbReference type="Ensembl" id="ENSMODT00000079644.1">
        <property type="protein sequence ID" value="ENSMODP00000054871.1"/>
        <property type="gene ID" value="ENSMODG00000002680.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100011562"/>
    <dbReference type="CTD" id="9470"/>
    <dbReference type="GeneTree" id="ENSGT00940000154694"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002680">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E type 2 isoformX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF17">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 19" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 19" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="234" mass="27095" checksum="A61A523CF87BCE00" modified="2019-12-11" version="1">MNNKFDALKDDDSGDHDQNEENNAQKDSEKERNERDRSQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKDNSSFRNTKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6L8</accession>
    <name>A0A5F8H6L8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PGAP3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the first step of the fatty acid remodeling, by removing the unsaturated acyl chain at sn-2 of inositol phosphate, generating a lyso-GPI intermediate. The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PGAP3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6L8"/>
    <dbReference type="Ensembl" id="ENSMODT00000073316.1">
        <property type="protein sequence ID" value="ENSMODP00000055583.1"/>
        <property type="gene ID" value="ENSMODG00000012824.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001304"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012824">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023972645" description="Post-GPI attachment to proteins factor 3" evidence="9">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="148" mass="16676" checksum="229637E3378D8EDF" modified="2019-12-11" version="1">MAGRTTLLALLAGAAALADASQGDREPVYRDCVLRCDEWNCSGAGLQHFRSHQPIYMSLAGWTCRDDCKYECMWLTVGLYLQEGYRVPQFHGKWPFSRFLFFQEPASAVASFLNGLANLVMLSRYRTSVPASSPMYHTCVAFAWFRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6L9</accession>
    <name>A0A5F8H6L9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Paired box 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAX2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000060041.1">
        <property type="protein sequence ID" value="ENSMODP00000055630.1"/>
        <property type="gene ID" value="ENSMODG00000019353.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157412"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019353">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000013">
        <property type="entry name" value="Paired box 8 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022130">
        <property type="entry name" value="Pax2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF19">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12403">
        <property type="entry name" value="Pax2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="394" mass="42473" checksum="865B8824BC6F6481" modified="2019-12-11" version="1">MDMHCKADPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGTGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQTSEHIKSEQGNEYSLPALTPGLDEVKSSLSASANPDXXXXXXXXXXXXXXXXRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTTYNEAWRFSNPALLSSPYYYSATPRGSAPAAAAAAYDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6M0</accession>
    <name>A0A5F8H6M0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bardet-Biedl syndrome 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BBS1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6M0"/>
    <dbReference type="Ensembl" id="ENSMODT00000059443.1">
        <property type="protein sequence ID" value="ENSMODP00000055432.1"/>
        <property type="gene ID" value="ENSMODG00000008186.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005232"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008186">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028784">
        <property type="entry name" value="BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032728">
        <property type="entry name" value="BBS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14779">
        <property type="entry name" value="BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bardet-Biedl syndrome 1 N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="167" mass="18480" checksum="8C7233D6EA2CAA27" modified="2019-12-11" version="1">MEKEVQSSDGSEFNSKWLDAHYDPMANIHTFSACLALADLHGDGEYKLVVGDLGPNGRQPRLKVLKGPSVLTESPLPSLPSAATAFLMDPHEPRTPALALASGPCVYVYKNLRPYFKFSLPPLPSNPLEQDLWNQAKEDRIDPLTLKEMLEGIREKAEVPLSVQSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6M2</accession>
    <name>A0A5F8H6M2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Aspartate beta-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ASPH</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6M2"/>
    <dbReference type="Ensembl" id="ENSMODT00000071110.1">
        <property type="protein sequence ID" value="ENSMODP00000054876.1"/>
        <property type="gene ID" value="ENSMODG00000008351.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156304"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008351">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062101">
        <property type="term" value="F:peptidyl-aspartic acid 3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000151">
        <property type="entry name" value="Aspartyl/asparaginyl beta-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000004">
        <property type="entry name" value="aspartyl/asparaginyl beta-hydroxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007943">
        <property type="entry name" value="Asp-B-hydro/Triadin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039038">
        <property type="entry name" value="ASPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12366">
        <property type="entry name" value="ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12366:SF33">
        <property type="entry name" value="ASPARTYL_ASPARAGINYL BETA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05279">
        <property type="entry name" value="Asp-B-Hydro_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartyl beta-hydroxylase/Triadin" evidence="15">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="14">
        <location>
            <begin position="648"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="251"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="815" mass="92404" checksum="728A514DF9AE7F84" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6M3</accession>
    <name>A0A5F8H6M3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6M3"/>
    <dbReference type="Ensembl" id="ENSMODT00000080081.1">
        <property type="protein sequence ID" value="ENSMODP00000055588.1"/>
        <property type="gene ID" value="ENSMODG00000023866.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023866">
        <property type="expression patterns" value="Expressed in testis and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="117"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="293"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="377"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="464"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="556"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="654"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="756"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="908" mass="100371" checksum="7119BE76C09AE9BD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6M5</accession>
    <name>A0A5F8H6M5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glycoprotein hormones alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CGA</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycoprotein hormones subunit alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6M5"/>
    <dbReference type="Ensembl" id="ENSMODT00000087010.1">
        <property type="protein sequence ID" value="ENSMODP00000055437.1"/>
        <property type="gene ID" value="ENSMODG00000018321.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012242"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018321">
        <property type="expression patterns" value="Expressed in ovary and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000011">
        <property type="entry name" value="Glycoprotein hormones alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000476">
        <property type="entry name" value="Glyco_hormone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11509">
        <property type="entry name" value="GLYCOPROTEIN HORMONE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11509:SF0">
        <property type="entry name" value="GLYCOPROTEIN HORMONES ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00236">
        <property type="entry name" value="Hormone_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00274">
        <property type="entry name" value="GLYCOHORMONE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00067">
        <property type="entry name" value="GHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00779">
        <property type="entry name" value="GLYCO_HORMONE_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50277">
        <property type="entry name" value="GLYCO_HORMONE_ALPHA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0372">Hormone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023968854" description="Glycoprotein hormones alpha chain" evidence="8">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="116" mass="12960" checksum="EC25A3E31AE1F11F" modified="2019-12-11" version="1">MDYYRKYAAVILATLSVFLHILHSFPDGEFIMQGCPECKLKENKYFSKLGAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKAFTKAACFAGLRTEDHFLLPSSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6M6</accession>
    <name>A0A5F8H6M6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cerebellar deration related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CDR2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDR2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6M6"/>
    <dbReference type="Ensembl" id="ENSMODT00000056711.1">
        <property type="protein sequence ID" value="ENSMODP00000055593.1"/>
        <property type="gene ID" value="ENSMODG00000007761.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018570"/>
    <dbReference type="OMA" id="GCRARQK"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007761">
        <property type="expression patterns" value="Expressed in testis and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026079">
        <property type="entry name" value="CDR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19232">
        <property type="entry name" value="CENTROCORTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19232:SF1">
        <property type="entry name" value="CEREBELLAR DEGENERATION-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="441" mass="50121" checksum="1F70D9DD44534B8D" modified="2019-12-11" version="1">MKIVLTSRTSPNSKKRSLEPLGNHALRTAGLDDLQGPLELCGPLKRSLGLKYLTKQVELLRQMNEQHAKVYEQLDVTARELEETNQKLVSDSKASQQKILSLTETIECLQSHVDHLQNQMEELKTSSEGRGNQERCEQRKSLHSFSCLKELYDLRKHFVYDHVFAEKITSMHNQQTPEEEENKNLKKTITVLQAQLSLERKKRMTMEEEYGLVLKENCDLEQQLGASDAYRARALELEAEVAEMRQMLQTEHPFVNGVEKLVPDSLFLSVKEPSQTLLEEMFLAGSELSKKPLKRSSSEVVLSSLAGSDIVKGHEETCIRKTEAMKQRGISLLHEVDTQYSALKVKYEELLKKCQKEEESLKHKAVQTSRGPTPAPNVRSLEAEPVPSSQELASIVPDSSSATSPPPEYKALFKEIFSCIKKTKQEIDEQRTKYQARSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6M7</accession>
    <name>A0A5F8H6M7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chemerin-like receptor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Chemerin chemokine-like receptor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Chemokine-like receptor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">G-protein coupled receptor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CMKLR2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chemokine-like receptor (CMKLR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6M7"/>
    <dbReference type="Ensembl" id="ENSMODT00000077584.1">
        <property type="protein sequence ID" value="ENSMODP00000054881.1"/>
        <property type="gene ID" value="ENSMODG00000046264.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160642"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000046264">
        <property type="expression patterns" value="Expressed in testis and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15119">
        <property type="entry name" value="7tmA_GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000034">
        <property type="entry name" value="G-protein coupled receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002275">
        <property type="entry name" value="CML2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000826">
        <property type="entry name" value="Formyl_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225:SF74">
        <property type="entry name" value="CHEMOKINE-LIKE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225">
        <property type="entry name" value="CHEMOTACTIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01146">
        <property type="entry name" value="GPR1ORPHANR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="73"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="373" mass="43306" checksum="0D7B9A22CBBA7CD3" modified="2019-12-11" version="1">MIVLQKNLIQLPMLQQEIIMEEIEYVFDEFENYTYASEYFQQELELEERSRLGPAQWISLVLYSLAFVLGVPGNAIVIWFTGFKWEKTVATLWFLNLAVADFVFLLFLPLYISYVAMNFHWPFGTWLCKANSFIALLNMFASVFFLTVISLDRYVHLIHPVFSQRHRTLRNALCAIGIIWLVAGLIAGPALYFRETLEHNNHTICYNNFHQSDDSIVLMRHHALTWIKFVLGYLLPLLTMIICYSLLALQVKRRAALTSSRHFWTILAVVLAFIICWTPFHLFSIWELSIHHSSAYHHVLQAGLPISTGLAFFNSCLNPLLYVLISKKFQARFQASVAELLKHTLREVSWSGTVSEQYKHSETKNLCLLEIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6M8</accession>
    <name>A0A5F8H6M8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Microtubule associated protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MAP7</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAP7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6M8"/>
    <dbReference type="Ensembl" id="ENSMODT00000087713.1">
        <property type="protein sequence ID" value="ENSMODP00000055214.1"/>
        <property type="gene ID" value="ENSMODG00000049358.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182941"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000049358">
        <property type="expression patterns" value="Expressed in testis and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008604">
        <property type="entry name" value="MAP7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF4">
        <property type="entry name" value="ENSCONSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05672">
        <property type="entry name" value="MAP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="729" mass="82517" checksum="1D3D0729BECF9CDD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6N1</accession>
    <name>A0A5F8H6N1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EIF2B1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6N1"/>
    <dbReference type="Ensembl" id="ENSMODT00000071622.1">
        <property type="protein sequence ID" value="ENSMODP00000055598.1"/>
        <property type="gene ID" value="ENSMODG00000049098.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074853"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000049098">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1070:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="203" mass="22374" checksum="F37FAF48655AC291" modified="2019-12-11" version="1">MKEDPDVASAVAAIRTLLEFLKRDKGETIQGLRANLKNAIKILCSVDSSVAVSSGGELFLRFISLTSLEYSDYLKCKKIMIERGELFLRRISLSRSKIADLCHTFIKDGARILTHAYSRVVLRVLEAAAAAKKRFSVYITESQPDLSGKKMAKALSSLNVPVTVILDAAVGLEPTRQLCVPKHRTSPSTLWQKVSSLCDSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6N2</accession>
    <name>A0A5F8H6N2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="33">Cadherin EGF LAG seven-pass G-type receptor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">CELSR3</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor that may have an important role in cell/cell signaling during nervous system formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000058914.1">
        <property type="protein sequence ID" value="ENSMODP00000055219.1"/>
        <property type="gene ID" value="ENSMODG00000013462.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160077"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013462">
        <property type="expression patterns" value="Expressed in cerebellum and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000013">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000021">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000011">
        <property type="entry name" value="cadherin EGF LAG seven-pass G-type receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000089">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000286">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000074">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000010">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000023">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000029">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000038">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000040">
        <property type="entry name" value="cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000113">
        <property type="entry name" value="Cadherin, EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000044">
        <property type="entry name" value="Cadherin, EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056286">
        <property type="entry name" value="Cadherin_CELSR1-3_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF38">
        <property type="entry name" value="CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23592">
        <property type="entry name" value="Cadherin_CELSR2_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="15 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 22" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="20 23" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="14 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0807">Transducer</keyword>
    <keyword evidence="8 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="2243"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="2281"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="2307"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="2350"/>
            <end position="2370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="2390"/>
            <end position="2423"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="32">
        <location>
            <begin position="69"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="32">
        <location>
            <begin position="177"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="32">
        <location>
            <begin position="285"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="32">
        <location>
            <begin position="391"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="32">
        <location>
            <begin position="496"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="32">
        <location>
            <begin position="598"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="32">
        <location>
            <begin position="701"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="32">
        <location>
            <begin position="807"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="32">
        <location>
            <begin position="931"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="27">
        <location>
            <begin position="1177"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="27">
        <location>
            <begin position="1217"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="26">
        <location>
            <begin position="1257"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="27">
        <location>
            <begin position="1464"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="27">
        <location>
            <begin position="1674"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="27">
        <location>
            <begin position="1710"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="28">
        <location>
            <begin position="1805"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="30">
        <location>
            <begin position="1837"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="29">
        <location>
            <begin position="2080"/>
            <end position="2237"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="31">
        <location>
            <begin position="2246"/>
            <end position="2412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="2051"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="2059"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="2087"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="1203"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="1490"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="1738"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1805"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1807"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1826"/>
            <end position="1835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2469" mass="269709" checksum="D5A11C8CB975778E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6N3</accession>
    <name>A0A5F8H6N3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Apoptotic protease-activating factor 1</fullName>
            <shortName evidence="10">APAF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">APAF1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer. Oligomerizes upon binding of cytochrome c and dATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6N3"/>
    <dbReference type="Ensembl" id="ENSMODT00000075611.1">
        <property type="protein sequence ID" value="ENSMODP00000054886.1"/>
        <property type="gene ID" value="ENSMODG00000007679.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157710"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007679">
        <property type="expression patterns" value="Expressed in spermatid and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043293">
        <property type="term" value="C:apoptosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08323">
        <property type="entry name" value="CARD_APAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000204">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000014">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.430:FF:000001">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.370:FF:000001">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000135">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000196">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000502">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017251">
        <property type="entry name" value="Apaf-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041452">
        <property type="entry name" value="APAF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037963">
        <property type="entry name" value="APAF1_CARD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048975">
        <property type="entry name" value="WHD_APAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845:SF5">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17908">
        <property type="entry name" value="APAF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21296">
        <property type="entry name" value="WHD_APAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037646">
        <property type="entry name" value="Apop_pept_activating-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CARD" evidence="13">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="610"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="652"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="694"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="738"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="834"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="958"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="999"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="1040"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="1082"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037646-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1208" mass="137585" checksum="200B1A55CD6330E3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6N7</accession>
    <name>A0A5F8H6N7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 1 regulatory inhibitor subunit 1C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PPP1R1C</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein phosphatase inhibitor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6N7"/>
    <dbReference type="STRING" id="13616.ENSMODP00000054891"/>
    <dbReference type="Ensembl" id="ENSMODT00000065189.1">
        <property type="protein sequence ID" value="ENSMODP00000054891.1"/>
        <property type="gene ID" value="ENSMODG00000010425.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160192"/>
    <dbReference type="InParanoid" id="A0A5F8H6N7"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010425">
        <property type="expression patterns" value="Expressed in spinal cord and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008466">
        <property type="entry name" value="PPP1R1A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15417:SF5">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15417">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05395">
        <property type="entry name" value="DARPP-32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="126" mass="14486" checksum="7227B21A8CA6B9CC" modified="2019-12-11" version="1">MEPNSPKKIQFAVPLFQSQIAPEAAEQIRKRRPTPASLVILNEHNSPEIDEKKVTNSQGEIIHRYNFNNCFLHFVIRVFSFPSDLPFPIMAGNMILILHVLSHNIYLSPCLSRCKRHLSLILEKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6N8</accession>
    <name>A0A5F8H6N8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6N8"/>
    <dbReference type="Ensembl" id="ENSMODT00000079373.1">
        <property type="protein sequence ID" value="ENSMODP00000055650.1"/>
        <property type="gene ID" value="ENSMODG00000012189.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156240"/>
    <dbReference type="OMA" id="GQLIMQY"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012189">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07141">
        <property type="entry name" value="ALDH_F1AB_F2_RALDH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000029">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="525" mass="58008" checksum="86B9317783ED1EF8" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6N9</accession>
    <name>A0A5F8H6N9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Spectrin beta, non-erythrocytic 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SPTBN4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000073491.1">
        <property type="protein sequence ID" value="ENSMODP00000055603.1"/>
        <property type="gene ID" value="ENSMODG00000007773.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156343"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007773">
        <property type="expression patterns" value="Expressed in cerebellum and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008091">
        <property type="term" value="C:spectrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000018">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000294">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016343">
        <property type="entry name" value="Spectrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002297">
        <property type="entry name" value="Spectrin_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="58"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="177"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1832"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1758"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1939"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1182"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1295"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1778"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1944"/>
            <end position="1957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1975" mass="222695" checksum="7BA50CF9BF181388" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F6SFH6</accession>
    <name>F6SFH6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="8">PARP</shortName>
            <ecNumber evidence="8">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PARP8</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_007486349.1">
        <property type="nucleotide sequence ID" value="XM_007486287.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6SFH6"/>
    <dbReference type="Ensembl" id="ENSMODT00000024677.4">
        <property type="protein sequence ID" value="ENSMODP00000024248.4"/>
        <property type="gene ID" value="ENSMODG00000019436.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100016129"/>
    <dbReference type="CTD" id="79668"/>
    <dbReference type="eggNOG" id="ENOG502QPRC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183129"/>
    <dbReference type="HOGENOM" id="CLU_021399_0_0_1"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019436">
        <property type="expression patterns" value="Expressed in spinal cord and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01341">
        <property type="entry name" value="ADP_ribosyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000007">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="1 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="10">
        <location>
            <begin position="572"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000024248.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="809" mass="90586" checksum="287B17D08D099EC1" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F6TIJ5</accession>
    <name>F6TIJ5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosyl-DNA phosphodiesterase 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">5'-tyrosyl-DNA phosphodiesterase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">TRAF and TNF receptor-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">TRAF and TNF receptor-associated protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TDP2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with TRAF2, TRAF3, TRAF5, TRAF6, TNFRSF8/CD30, TNFRSF5/CD40, TNFRSF1B/TNF-R75, ETS1, ETS2, FLI1, SMAD3 and ACVR1B/ALK4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the CCR4/nocturin family. TTRAP/TDP2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056679494.1">
        <property type="nucleotide sequence ID" value="XM_056823516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6TIJ5"/>
    <dbReference type="Ensembl" id="ENSMODT00000014867.3">
        <property type="protein sequence ID" value="ENSMODP00000014599.3"/>
        <property type="gene ID" value="ENSMODG00000011653.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100024191"/>
    <dbReference type="CTD" id="51567"/>
    <dbReference type="eggNOG" id="KOG2756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014242"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011653">
        <property type="expression patterns" value="Expressed in placenta and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6TIJ5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070259">
        <property type="term" value="F:tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14344">
        <property type="entry name" value="UBA_TYDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000142">
        <property type="entry name" value="Tyrosyl-DNA phosphodiesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000024">
        <property type="entry name" value="Tyrosyl-DNA phosphodiesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="17">
        <location>
            <begin position="118"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000014599.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="355" mass="40243" checksum="E56073D4D5304862" modified="2013-01-09" version="2">MEVDGTVAAPEERVVEERQRLCAEFAAITGRGCDVAQCYLAENDWQMERALNSYFEAAVDLGALDSRTPTPPTPPLAPTPAEAVCVDLTNEPTIDITNTDVNIENCVQKEDDSTFSLITWNIDGLDINNLQARARSVCEYLALYTPDVVFLQEVIPPYYDYLKKRATSYRIISGNEDGYFTVVMLKKSRVKLMSHEITPFPATQMMRNLLCVHVSVCGNELCLMSSHLESTRNHSRERMNQLKIVLKKMQEIPESVTVIFGGDTNLRDHEVSKVGGLPDKILDVWEFLGKPEHCRYTWDTQANTNLAIEASCKLRFDRIFFRPAAARWQSRESTNSGRCEFKSNLRYFQLCDPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F6TIN1</accession>
    <name>F6TIN1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Twinfilin actin binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TWF2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6TIN1"/>
    <dbReference type="Ensembl" id="ENSMODT00000014862.2">
        <property type="protein sequence ID" value="ENSMODP00000014594.2"/>
        <property type="gene ID" value="ENSMODG00000011648.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063868"/>
    <dbReference type="HOGENOM" id="CLU_031995_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011648">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000012">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF9">
        <property type="entry name" value="TWINFILIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="8">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="8">
        <location>
            <begin position="177"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000014594.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="255" mass="28858" checksum="0C6C65F55D34F00E" modified="2019-12-11" version="2">MAHQTGIHATPELKDFFAKARNGSIRLIKVVIEDEQLVLGAFREPAQGWEQDYDAAVLPLLDEGQPCYILYRLDSHNAQGFQWIFIAWSPDSSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSFSGYQKHVSSCAAPAPLTMAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQQAIALLKQKKVNYVQLKLDLERETIELVHTNPTEVADLPKRVPQDSARYHFFLYKHSHEGDYLESVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F6TIN8</accession>
    <name>F6TIN8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell growth regulator with ring finger domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CGRRF1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F6TIN8"/>
    <dbReference type="Ensembl" id="ENSMODT00000014861.4">
        <property type="protein sequence ID" value="ENSMODP00000014593.4"/>
        <property type="gene ID" value="ENSMODG00000011646.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004542"/>
    <dbReference type="HOGENOM" id="CLU_053217_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011646">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042496">
        <property type="entry name" value="CGRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15379">
        <property type="entry name" value="CELL GROWTH REGULATOR WITH RING FINGER DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15379:SF2">
        <property type="entry name" value="CELL GROWTH REGULATOR WITH RING FINGER DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000014593.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="299" mass="33949" checksum="399FA5D404B3965E" modified="2019-12-11" version="3">MAAVFLVMLYEYSPLFYIAVVFTCFIVTTGLVLGWFGLEVPVILRNSEEIEFNTRVSKKEMKQVKNPFGLAITNPASASVTNGIALTPDCIEESILTCYWGCDVQELYEALQKHVYVSRISTPQALEDAIYSKYVYREQHFVKKNNKEEKYCQLPSDAKIEDFGIVPRSQYPLVALLTLADEDSQGLYDIISMVTVIHIPDKKYKLSCRILYQYVLLAQGQFHDLKQLFMSANNNTPSLSNSSPGEQSTDRHLLEKAGLAESEVEQYEENSKDCVVCQNGKSIYNRIDFGATKMHLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F6W162</accession>
    <name>F6W162_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="2">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">OSGEPL1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="F6W162"/>
    <dbReference type="Ensembl" id="ENSMODT00000014583.3">
        <property type="protein sequence ID" value="ENSMODP00000014319.3"/>
        <property type="gene ID" value="ENSMODG00000011455.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153744"/>
    <dbReference type="HOGENOM" id="CLU_023208_1_2_1"/>
    <dbReference type="OMA" id="NAAMIGC"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011455">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000106">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="59"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000014319.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="364" mass="39595" checksum="C0BF7651FABE3F62" modified="2019-12-11" version="2">MLTLNKTLGMPSRLSRWQIPGFLRSFTFRPGKQFLHKLVLGIETSCDDTAAAVVDESGNILGEAIRSQTEVHLKTGGIIPSVAQRLHRENIEQIVKETLSASGVTPNELSAIATTVKPGLALSLGVGVAYSLQLVNQYKKPFIPIHHMEAHALTIRLTNKVDFPFLVLLVSGGHCLLAIVQGVSDFLLLGKSLDIAPGDMLDKVARRLSLIKHPAYSAMSGGKAIEHLAKQGNRSHFDFQHPLHYCKNCDFSFCGLQTAVDKIITQKEKEEGIEKGQILSCAADIAASVQHIVASHIAKRTHRAILFCQQRGFLTPSNAILVVSGGVASNLYIRRSLEIVTKATNCILLCPPLRLCTDNGIMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F6WRS3</accession>
    <name>F6WRS3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6WRS3"/>
    <dbReference type="Ensembl" id="ENSMODT00000030744.3">
        <property type="protein sequence ID" value="ENSMODP00000029171.3"/>
        <property type="gene ID" value="ENSMODG00000023262.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182886"/>
    <dbReference type="HOGENOM" id="CLU_059260_1_0_1"/>
    <dbReference type="OMA" id="LSWTMVF"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023262">
        <property type="expression patterns" value="Expressed in ovary and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF59">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000029171.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="231" mass="26776" checksum="D17976D16359651A" modified="2019-12-11" version="3">MVFLIEYAGSLFIYLLFYLRMPFVYGLEKKLMSRRLPVVNLACICHSSHYIKRLIETIFVHRFSHGTMPLKSIVKNCFFYWGFAAWLAYYINHPLYTPPSYGQKQINFSLITFLLCEAGNFSIHVELNNLRGNGPKTRRIPYPTKNPFTWLFFFVSCPNYTYEVGAWISFTIMTQCVPVGLFTLVGFIQMTIWAKDKHCTYALIGAAHDSRGSGSQTFQLLIHLKCCRPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F6WS94</accession>
    <name>F6WS94_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LSM family member 14B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM14B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F6WS94"/>
    <dbReference type="Ensembl" id="ENSMODT00000030741.3">
        <property type="protein sequence ID" value="ENSMODP00000029168.2"/>
        <property type="gene ID" value="ENSMODG00000016690.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156010"/>
    <dbReference type="HOGENOM" id="CLU_019221_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016690">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF1">
        <property type="entry name" value="PROTEIN LSM14 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="DFDF" evidence="6">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="7">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="3">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="4">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000029168.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="304" mass="33650" checksum="D3FEB44CAC0ED0D8" modified="2013-01-09" version="2">MPPYNQLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDMSSEPHQLSSKGAGFPSIPVRKSPMVEQAVQTGSVDNLNAKKLLPTKPPMGIQRNGRQVQPNSKTSDIVQPVTVQNQGQVNDENRRPQRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKTEKEEKGDPAVVTQNNDSTTEEDLLGPNCYYDKSKSFFDNISSELKSSSRRTTWAEERKLNTETFGVSGRFLRGRSFRGGFRGGRGTGAARRNQTSHRAGTGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>F6X447</accession>
    <name>F6X447_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA topoisomerase I</fullName>
            <ecNumber evidence="11">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TOP1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Interacts with ERCC6. Interacts with TPRN; TPRN interacts with a number of DNA damage response proteins, is recruited to sites of DNA damage and may play a role in DNA damage repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="11"/>
    <dbReference type="RefSeq" id="XP_007474400.1">
        <property type="nucleotide sequence ID" value="XM_007474338.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6X447"/>
    <dbReference type="FunCoup" id="F6X447">
        <property type="interactions" value="2309"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000000688"/>
    <dbReference type="Ensembl" id="ENSMODT00000000703.4">
        <property type="protein sequence ID" value="ENSMODP00000000688.3"/>
        <property type="gene ID" value="ENSMODG00000000573.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100032710"/>
    <dbReference type="KEGG" id="mdo:100032710"/>
    <dbReference type="CTD" id="7150"/>
    <dbReference type="eggNOG" id="KOG0981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155006"/>
    <dbReference type="HOGENOM" id="CLU_009193_0_1_1"/>
    <dbReference type="InParanoid" id="F6X447"/>
    <dbReference type="OMA" id="HRWKEVK"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000573">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001673">
        <property type="term" value="C:male germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097100">
        <property type="term" value="F:supercoiled DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040016">
        <property type="term" value="P:embryonic cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF5">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46596">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, dispensable insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 11" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="14">
        <location>
            <begin position="377"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="661"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000000688.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="782" mass="92720" checksum="ADDA3DD19591B17E" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>F6Y770</accession>
    <name>F6Y770_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Insulin-like growth factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Insulin-like growth factor I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">IGF1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007503393.1">
        <property type="nucleotide sequence ID" value="XM_007503331.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6Y770"/>
    <dbReference type="Ensembl" id="ENSMODT00000038033.2">
        <property type="protein sequence ID" value="ENSMODP00000036442.2"/>
        <property type="gene ID" value="ENSMODG00000002506.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021295"/>
    <dbReference type="CTD" id="3479"/>
    <dbReference type="GeneTree" id="ENSGT00940000159081"/>
    <dbReference type="HOGENOM" id="CLU_3425062_0_0_1"/>
    <dbReference type="OMA" id="TLLFKCC"/>
    <dbReference type="OrthoDB" id="8936076at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002506">
        <property type="expression patterns" value="Expressed in liver and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6Y770">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04368">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.100.10:FF:000001">
        <property type="entry name" value="insulin-like growth factor I isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022350">
        <property type="entry name" value="IGF-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022341">
        <property type="entry name" value="IGF-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46845">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46845:SF1">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02002">
        <property type="entry name" value="INSLNLIKEGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02005">
        <property type="entry name" value="INSLNLIKEGF1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Insulin-like" evidence="11">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="119"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="95"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR622350-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000036442.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="190" mass="21658" checksum="21A2D57AE383FBDA" modified="2019-12-11" version="2">MDKFNSLSTQFSKCCLCDFLKVKMHTVSSVHLFYLALCLLTLTSSATAGPETLCGAELVDALQFVCGERGFYFSKPTGYGSSSRRLHHTGIVDECCFRSCDLRRLEMYCAPIKPAKSARSVRAQRHTDMPKAQKYQPPSTNKKTKAERRRKGDPFEECKQRELRKQELQNVRAAIQGRRMNMPPRRDPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>F6YXY3</accession>
    <name>F6YXY3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Huntingtin-interacting protein 1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">HIP1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Interacts with actin; homodimerization promotes actin binding. Interacts with CLTB. Interacts with HIP1. Interacts (via ENTH and I/LWEQ domains) with BCL2L10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6YXY3"/>
    <dbReference type="Ensembl" id="ENSMODT00000030073.3">
        <property type="protein sequence ID" value="ENSMODP00000028490.3"/>
        <property type="gene ID" value="ENSMODG00000013732.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153594"/>
    <dbReference type="HOGENOM" id="CLU_006034_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013732">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051050">
        <property type="term" value="P:positive regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000002">
        <property type="entry name" value="Huntingtin interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000002">
        <property type="entry name" value="Huntingtin interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000012">
        <property type="entry name" value="Huntingtin interacting protein 1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032422">
        <property type="entry name" value="HIP1_clath-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF14">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16515">
        <property type="entry name" value="HIP1_clath_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="16">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="17">
        <location>
            <begin position="682"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="926"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="370"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000028490.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="948" mass="106410" checksum="989C1C0A9F4DB0BE" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F6Z9Y6</accession>
    <name>F6Z9Y6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DnaJ homolog subfamily C member 5B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DNAJC5B</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with the chaperone complex consisting of HSC70 and SGTA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6Z9Y6"/>
    <dbReference type="Ensembl" id="ENSMODT00000010210.4">
        <property type="protein sequence ID" value="ENSMODP00000010018.3"/>
        <property type="gene ID" value="ENSMODG00000008051.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100029362"/>
    <dbReference type="KEGG" id="mdo:100029362"/>
    <dbReference type="CTD" id="85479"/>
    <dbReference type="eggNOG" id="KOG0716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159294"/>
    <dbReference type="HOGENOM" id="CLU_017633_14_1_1"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008051">
        <property type="expression patterns" value="Expressed in testis and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000017">
        <property type="entry name" value="dnaJ homolog subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF6">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000010018.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="205" mass="23521" checksum="31551717BD636A6E" modified="2013-01-09" version="2">MSQSEQYTNQMADQRQRAMSTSGEALYEILGLQKGASQEEIKKTYRKLALKHHPDKNPDNPEAAEKFKEINNAHTILTDSTKRNIYDKYGSLGLYVAEQFGEENVNTYFMLSSWWAKTLFVLFGILTGCYFCCCLCCCCNCCCGRCRPKSPRGTEAEFYVSPEDLEEQIRHDMEKEAEFPTTLQPSCTNEKTQLIRECRTYTADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>F7AM28</accession>
    <name>F7AM28_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7AM28"/>
    <dbReference type="Ensembl" id="ENSMODT00000003154.3">
        <property type="protein sequence ID" value="ENSMODP00000003088.3"/>
        <property type="gene ID" value="ENSMODG00000025255.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154838"/>
    <dbReference type="HOGENOM" id="CLU_004111_3_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025255">
        <property type="expression patterns" value="Expressed in blood and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01469">
        <property type="entry name" value="vWA_integrins_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000005">
        <property type="entry name" value="Integrin alpha L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000004">
        <property type="entry name" value="Integrin subunit alpha M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000012">
        <property type="entry name" value="Integrin, alpha 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1460:FF:000001">
        <property type="entry name" value="Integrin, alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048633">
        <property type="entry name" value="ITGAX-like_Ig_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF118">
        <property type="entry name" value="INTEGRIN ALPHA-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00357">
        <property type="entry name" value="Integrin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21520">
        <property type="entry name" value="ITGAX-like_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0401">Integrin</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023973664" description="VWFA domain-containing protein" evidence="16">
        <location>
            <begin position="18"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1096"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="17">
        <location>
            <begin position="150"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="443"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="506"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="569"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000003088.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1145" mass="126329" checksum="58275F470FBFC025" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F7AM49</accession>
    <name>F7AM49_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DIS3 like 3'-5' exoribonuclease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DIS3L2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7AM49"/>
    <dbReference type="Ensembl" id="ENSMODT00000003148.3">
        <property type="protein sequence ID" value="ENSMODP00000003082.3"/>
        <property type="gene ID" value="ENSMODG00000025712.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063106"/>
    <dbReference type="HOGENOM" id="CLU_1726502_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025712">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7AM49">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000003">
        <property type="entry name" value="DIS3-like exonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000003">
        <property type="entry name" value="DIS3-like exonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="10">
        <location>
            <begin position="351"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000003082.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="780" mass="86847" checksum="978C768A96F59DD6" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>F7BP67</accession>
    <name>F7BP67_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Thyroid hormone receptor beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">THRB</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7BP67"/>
    <dbReference type="Ensembl" id="ENSMODT00000016580.3">
        <property type="protein sequence ID" value="ENSMODP00000016280.3"/>
        <property type="gene ID" value="ENSMODG00000014903.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156809"/>
    <dbReference type="HOGENOM" id="CLU_007368_18_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014903">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7BP67">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06961">
        <property type="entry name" value="NR_DBD_TR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06935">
        <property type="entry name" value="NR_LBD_TR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000006">
        <property type="entry name" value="Thyroid hormone receptor beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000011">
        <property type="entry name" value="Thyroid hormone receptor beta isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF210">
        <property type="entry name" value="THYROID HORMONE RECEPTOR BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="134"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000016280.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="378" mass="43200" checksum="F57B57758EA50535" modified="2019-12-11" version="2">MLPCSRSKNQSWYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKTIGHKPEPTDEEWDLIRTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSQFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLASVERIEKCQEGFLLAFEHYINYRKHHVAHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F7BP74</accession>
    <name>F7BP74_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pleckstrin homology and RhoGEF domain containing G4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000029841.2">
        <property type="protein sequence ID" value="ENSMODP00000028259.2"/>
        <property type="gene ID" value="ENSMODG00000005997.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158845"/>
    <dbReference type="HOGENOM" id="CLU_001356_3_0_1"/>
    <dbReference type="OMA" id="HGHATDW"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005997">
        <property type="expression patterns" value="Expressed in cerebellum and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13242">
        <property type="entry name" value="PH_puratrophin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000078">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052231">
        <property type="entry name" value="Rho_GEF_signaling-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845:SF4">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING, FAMILY G (WITH RHOGEF DOMAIN) MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="810"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1238"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000028259.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1292" mass="140430" checksum="1100B3C349AEBA32" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F7C0V6</accession>
    <name>F7C0V6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyadenylate-binding protein-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAIP1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7C0V6"/>
    <dbReference type="Ensembl" id="ENSMODT00000025814.3">
        <property type="protein sequence ID" value="ENSMODP00000025363.3"/>
        <property type="gene ID" value="ENSMODG00000020276.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153432"/>
    <dbReference type="HOGENOM" id="CLU_044856_1_0_1"/>
    <dbReference type="OMA" id="EQPACFE"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020276">
        <property type="expression patterns" value="Expressed in ovary and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000016">
        <property type="entry name" value="polyadenylate-binding protein-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF15">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MIF4G" evidence="8">
        <location>
            <begin position="179"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000025363.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="512" mass="56003" checksum="07D601376897BE20" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>F7D3Z8</accession>
    <name>F7D3Z8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Discoidin domain-containing receptor 2</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">CD167 antigen-like family member B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Neurotrophic tyrosine kinase, receptor-related 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Receptor protein-tyrosine kinase TKT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Tyrosine-protein kinase TYRO10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">DDR2</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_056671443.1">
        <property type="nucleotide sequence ID" value="XM_056815465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7D3Z8"/>
    <dbReference type="FunCoup" id="F7D3Z8">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000001377"/>
    <dbReference type="Ensembl" id="ENSMODT00000001405.4">
        <property type="protein sequence ID" value="ENSMODP00000001377.4"/>
        <property type="gene ID" value="ENSMODG00000001151.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100015989"/>
    <dbReference type="KEGG" id="mdo:100015989"/>
    <dbReference type="CTD" id="4921"/>
    <dbReference type="eggNOG" id="KOG1094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154842"/>
    <dbReference type="HOGENOM" id="CLU_008873_2_0_1"/>
    <dbReference type="InParanoid" id="F7D3Z8"/>
    <dbReference type="OMA" id="KWLRWKN"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001151">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038062">
        <property type="term" value="F:protein tyrosine kinase collagen receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031214">
        <property type="term" value="P:biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035988">
        <property type="term" value="P:chondrocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003416">
        <property type="term" value="P:endochondral bone growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090091">
        <property type="term" value="P:positive regulation of extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010763">
        <property type="term" value="P:positive regulation of fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048146">
        <property type="term" value="P:positive regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030500">
        <property type="term" value="P:regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034103">
        <property type="term" value="P:regulation of tissue remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05095">
        <property type="entry name" value="PTKc_DDR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000007">
        <property type="entry name" value="Discoidin domain receptor tyrosine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1190:FF:000001">
        <property type="entry name" value="Discoidin domain receptor tyrosine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000053">
        <property type="entry name" value="Epithelial discoidin domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000082">
        <property type="entry name" value="Epithelial discoidin domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048525">
        <property type="entry name" value="DDR1-2_DS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF295">
        <property type="entry name" value="DISCOIDIN DOMAIN-CONTAINING RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21114">
        <property type="entry name" value="DDR1-2_DS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0892">Osteogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 28" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023924530" description="Discoidin domain-containing receptor 2" evidence="28">
        <location>
            <begin position="46"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="30">
        <location>
            <begin position="52"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="585"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00065042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00070183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00078393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00079441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00079636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000001377.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="879" mass="98972" checksum="0908DACB5EC09671" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F7F9Y3</accession>
    <name>F7F9Y3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicastrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NCSTN</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001379384.2">
        <property type="nucleotide sequence ID" value="XM_001379347.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7F9Y3"/>
    <dbReference type="Ensembl" id="ENSMODT00000012086.3">
        <property type="protein sequence ID" value="ENSMODP00000011863.2"/>
        <property type="gene ID" value="ENSMODG00000009496.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100029698"/>
    <dbReference type="KEGG" id="mdo:100029698"/>
    <dbReference type="CTD" id="23385"/>
    <dbReference type="eggNOG" id="KOG2657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014633"/>
    <dbReference type="HOGENOM" id="CLU_024257_0_0_1"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009496">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03881">
        <property type="entry name" value="M28_Nicastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000030">
        <property type="entry name" value="nicastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041084">
        <property type="entry name" value="Ncstrn_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008710">
        <property type="entry name" value="Nicastrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092:SF0">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18266">
        <property type="entry name" value="Ncstrn_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05450">
        <property type="entry name" value="Nicastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003352934" description="Nicastrin" evidence="17">
        <location>
            <begin position="50"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Nicastrin small lobe" evidence="18">
        <location>
            <begin position="65"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011863.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="723" mass="79923" checksum="E7FA833F4D2C8698" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3D0</accession>
    <name>A0A5F8G3D0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">ITGB4</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="23">Cell junction</location>
            <location evidence="23">Hemidesmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 24">Cell membrane</location>
            <topology evidence="2 24">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 24">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="FunCoup" id="A0A5F8G3D0">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000041936"/>
    <dbReference type="Ensembl" id="ENSMODT00000071130.1">
        <property type="protein sequence ID" value="ENSMODP00000041936.1"/>
        <property type="gene ID" value="ENSMODG00000007605.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100027264"/>
    <dbReference type="CTD" id="3691"/>
    <dbReference type="GeneTree" id="ENSGT01150000286919"/>
    <dbReference type="InParanoid" id="A0A5F8G3D0"/>
    <dbReference type="OMA" id="HTKFRQQ"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007605">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031994">
        <property type="term" value="F:insulin-like growth factor I binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038132">
        <property type="term" value="F:neuregulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031581">
        <property type="term" value="P:hemidesmosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048333">
        <property type="term" value="P:mesodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035878">
        <property type="term" value="P:nail development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032290">
        <property type="term" value="P:peripheral nervous system myelin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043589">
        <property type="term" value="P:skin morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061450">
        <property type="term" value="P:trophoblast cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000212">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000215">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000287">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000146">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000424">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000452">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1510:FF:000006">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2030:FF:000004">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000036">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.30:FF:000003">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040622">
        <property type="entry name" value="EGF_integrin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012013">
        <property type="entry name" value="Integrin_bsu-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012896">
        <property type="entry name" value="Integrin_bsu_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036349">
        <property type="entry name" value="Integrin_bsu_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF42">
        <property type="entry name" value="INTEGRIN BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18372">
        <property type="entry name" value="I-EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07965">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002513">
        <property type="entry name" value="Integrin_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01242">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69687">
        <property type="entry name" value="Integrin beta tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 24" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="14" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 24" id="KW-0401">Integrin</keyword>
    <keyword evidence="22" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 27" id="KW-0732">Signal</keyword>
    <keyword evidence="7 24 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023834078" description="Integrin beta" evidence="27">
        <location>
            <begin position="26"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="1119"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="1212"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="1566"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="1679"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1406"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00060371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1864" mass="208130" checksum="940C78295E3092B0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3D1</accession>
    <name>A0A5F8G3D1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLTA</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3D1"/>
    <dbReference type="Ensembl" id="ENSMODT00000080448.1">
        <property type="protein sequence ID" value="ENSMODP00000041962.1"/>
        <property type="gene ID" value="ENSMODG00000002610.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157347"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002610">
        <property type="expression patterns" value="Expressed in ovary and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF1">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00224">
        <property type="entry name" value="CLATHRIN_LIGHT_CHN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00581">
        <property type="entry name" value="CLATHRIN_LIGHT_CHN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="235" mass="25541" checksum="159642E3B2FF9246" modified="2019-12-11" version="1">MAEVDPFGAAAAPASAPGGPAVGNGVASGGSSEEDPAAAFLAQQESEIAGIENDEGFSILDTGSVPASLQGEPPGGPDAIDAVMNGEYYQESNGPTDSYAAISQVDRLQSEPESIRKWREEQMERLEVLDANSRKQEAEWKEKAIKELEEWYARQDEQLQKTKVNNSTNINHPCYSLEQAAEEAFVNDVEETSPGTEWERVARLCDFNPKSSKQAKDVSRMRSVLISLKQAPLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3D2</accession>
    <name>A0A5F8G3D2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho guanine nucleotide exchange factor 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ARHGEF33</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3D2"/>
    <dbReference type="Ensembl" id="ENSMODT00000075895.1">
        <property type="protein sequence ID" value="ENSMODP00000041941.1"/>
        <property type="gene ID" value="ENSMODG00000008757.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008757">
        <property type="expression patterns" value="Expressed in cerebellum and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042849">
        <property type="entry name" value="ARHGEF33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46944">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46944:SF1">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="281"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="850" mass="96358" checksum="6D80C8F83934CCB6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3D3</accession>
    <name>A0A5F8G3D3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PCBD2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3D3"/>
    <dbReference type="Ensembl" id="ENSMODT00000058069.1">
        <property type="protein sequence ID" value="ENSMODP00000041930.1"/>
        <property type="gene ID" value="ENSMODG00000038053.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007221"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000038053">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF15">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="130" mass="14862" checksum="F1876188F99CD2D1" modified="2019-12-11" version="1">MSAAGSVAAVVLRFRGRLIPALLGSPWVAPGKSRSLSVMSAESHWLTTEERNQVIHDLKASGWSELNERDAIYKEFCFKNFNQAFGFMSRVALQAEKMNHHPEWFNVYNKIKSIIVGQSKVRKLRLREEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3D6</accession>
    <name>A0A5F8G3D6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FA complementation group I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FANCI</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3D6"/>
    <dbReference type="Ensembl" id="ENSMODT00000081796.1">
        <property type="protein sequence ID" value="ENSMODP00000041988.1"/>
        <property type="gene ID" value="ENSMODG00000019568.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005855"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019568">
        <property type="expression patterns" value="Expressed in hindlimb bud and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11720">
        <property type="entry name" value="FANCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026171">
        <property type="entry name" value="FANCI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029310">
        <property type="entry name" value="FANCI_HD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029312">
        <property type="entry name" value="FANCI_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029308">
        <property type="entry name" value="FANCI_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029305">
        <property type="entry name" value="FANCI_S1-cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029315">
        <property type="entry name" value="FANCI_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029313">
        <property type="entry name" value="FANCI_S3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029314">
        <property type="entry name" value="FANCI_S4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818">
        <property type="entry name" value="BC025462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP I PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14679">
        <property type="entry name" value="FANCI_HD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14680">
        <property type="entry name" value="FANCI_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14675">
        <property type="entry name" value="FANCI_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14674">
        <property type="entry name" value="FANCI_S1-cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14676">
        <property type="entry name" value="FANCI_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14677">
        <property type="entry name" value="FANCI_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14678">
        <property type="entry name" value="FANCI_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCI solenoid 1 cap" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 1" evidence="3">
        <location>
            <begin position="64"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 2" evidence="4">
        <location>
            <begin position="379"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 3" evidence="5">
        <location>
            <begin position="812"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 4" evidence="6">
        <location>
            <begin position="982"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1267" mass="142304" checksum="B4903B6A361D2C01" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3E1</accession>
    <name>A0A5F8G3E1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Folliculin interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FNIP1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FNIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3E1"/>
    <dbReference type="Ensembl" id="ENSMODT00000053335.1">
        <property type="protein sequence ID" value="ENSMODP00000041951.1"/>
        <property type="gene ID" value="ENSMODG00000014112.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009391"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014112">
        <property type="expression patterns" value="Expressed in endometrium and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037545">
        <property type="entry name" value="DENN_FNIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028086">
        <property type="entry name" value="FNIP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026156">
        <property type="entry name" value="FNIP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028085">
        <property type="entry name" value="FNIP_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF12">
        <property type="entry name" value="FOLLICULIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14638">
        <property type="entry name" value="FNIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14637">
        <property type="entry name" value="FNIP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02073">
        <property type="entry name" value="FOLLICULNIP1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51836">
        <property type="entry name" value="DENN_FNIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FNIP1/2-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="893"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1134" mass="127097" checksum="911D34158BE10A99" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3E2</accession>
    <name>A0A5F8G3E2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Essential for reactive oxygen species protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">OGFOD3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYBC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3E2"/>
    <dbReference type="Ensembl" id="ENSMODT00000076124.1">
        <property type="protein sequence ID" value="ENSMODP00000041984.1"/>
        <property type="gene ID" value="ENSMODG00000007122.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005895"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007122">
        <property type="expression patterns" value="Expressed in endometrium and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027846">
        <property type="entry name" value="Cybc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31837">
        <property type="entry name" value="CYTOCHROME B-245 CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31837:SF3">
        <property type="entry name" value="CYTOCHROME B-245 CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15169">
        <property type="entry name" value="Cybc1_Eros"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="176" mass="20182" checksum="17FF4ACA355330DD" modified="2019-12-11" version="1">MYMQVETRTGSFLHLKRSPGIRSWSLLVDNLGWKFFYVTGCLFVAVQNLEDWEEALFDKNTGKVILKTFNLYRKILTVSRACHEQVVVGLKDIQDVNVIEEKVRYFGKGYTVILRFATGFSHPLTQSAVMGHRSDVEIIAKLITNFLELHQPESLKDLSQSSDTEASDVDEPRHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3E4</accession>
    <name>A0A5F8G3E4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ankyrin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ANK1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000071160.1">
        <property type="protein sequence ID" value="ENSMODP00000041940.1"/>
        <property type="gene ID" value="ENSMODG00000010432.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155760"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010432">
        <property type="expression patterns" value="Expressed in blood and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000001">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000002">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000002">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040745">
        <property type="entry name" value="Ankyrin_UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF71">
        <property type="entry name" value="ANKYRIN 1, ERYTHROCYTIC A ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17809">
        <property type="entry name" value="UPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="398"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="464"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="596"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="629"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="662"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="695"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="728"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="11">
        <location>
            <begin position="852"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="10">
        <location>
            <begin position="1218"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1414" mass="154114" checksum="EDC998DF133CE2A5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3E5</accession>
    <name>A0A5F8G3E5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Papilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PAPLN</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the papilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3E5"/>
    <dbReference type="Ensembl" id="ENSMODT00000069788.1">
        <property type="protein sequence ID" value="ENSMODP00000041998.1"/>
        <property type="gene ID" value="ENSMODG00000006768.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156891"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006768">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22635">
        <property type="entry name" value="Kunitz_papilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000017">
        <property type="entry name" value="papilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023836329" description="Papilin" evidence="13">
        <location>
            <begin position="22"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="759"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="829"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="943"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="1019"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="16">
        <location>
            <begin position="1117"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="596"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="691"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1166" mass="128522" checksum="5C2815167103EF4C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3E6</accession>
    <name>A0A5F8G3E6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">A-kinase anchor protein 10, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dual specificity A kinase-anchoring protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein kinase A-anchoring protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">AKAP10</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3E6"/>
    <dbReference type="Ensembl" id="ENSMODT00000077658.1">
        <property type="protein sequence ID" value="ENSMODP00000041956.1"/>
        <property type="gene ID" value="ENSMODG00000010870.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015077"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010870">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08735">
        <property type="entry name" value="RGS_AKAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08721">
        <property type="entry name" value="RGS_AKAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000018">
        <property type="entry name" value="A-kinase anchor protein 10, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000022">
        <property type="entry name" value="A-kinase anchor protein 10, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000005">
        <property type="entry name" value="Putative A-kinase anchor protein 10 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RGS" evidence="15">
        <location>
            <begin position="110"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="15">
        <location>
            <begin position="362"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="678" mass="75981" checksum="51401378B1E76750" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3E7</accession>
    <name>A0A5F8G3E7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">STK39</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3E7"/>
    <dbReference type="Ensembl" id="ENSMODT00000069489.1">
        <property type="protein sequence ID" value="ENSMODP00000041945.1"/>
        <property type="gene ID" value="ENSMODG00000007566.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154621"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007566">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06610">
        <property type="entry name" value="STKc_OSR1_SPAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000114">
        <property type="entry name" value="serine/threonine-protein kinase OSR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000068">
        <property type="entry name" value="STE20/SPS1-related proline-alanine-rich protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF14">
        <property type="entry name" value="STE20_SPS1-RELATED PROLINE-ALANINE-RICH PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="60"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="357"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="541" mass="59372" checksum="BA8C914FB260DDF9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3E8</accession>
    <name>A0A5F8G3E8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nexilin F-actin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NEXN</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3E8"/>
    <dbReference type="Ensembl" id="ENSMODT00000069037.1">
        <property type="protein sequence ID" value="ENSMODP00000041977.1"/>
        <property type="gene ID" value="ENSMODG00000020802.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111176"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020802">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508">
        <property type="entry name" value="MITOGUARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508:SF4">
        <property type="entry name" value="MITOGUARDIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="508"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="301"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="602" mass="69792" checksum="393BDF8D20C45A31" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3E9</accession>
    <name>A0A5F8G3E9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CAP-Gly domain containing linker protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CLIP1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000087433.1">
        <property type="protein sequence ID" value="ENSMODP00000042003.1"/>
        <property type="gene ID" value="ENSMODG00000012253.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155122"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012253">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000002">
        <property type="entry name" value="CAP-Gly domain containing linker protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000001">
        <property type="entry name" value="Putative CAP-Gly domain-containing linker protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF44">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1268"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="402"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="576"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="761"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1122"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1312" mass="147349" checksum="95EB1CE50927320C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3F0</accession>
    <name>A0A5F8G3F0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Huntingtin interacting protein 1 related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HIP1R</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3F0"/>
    <dbReference type="Ensembl" id="ENSMODT00000058118.1">
        <property type="protein sequence ID" value="ENSMODP00000041989.1"/>
        <property type="gene ID" value="ENSMODG00000012341.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153594"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012341">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000002">
        <property type="entry name" value="Huntingtin interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000012">
        <property type="entry name" value="Huntingtin interacting protein 1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032422">
        <property type="entry name" value="HIP1_clath-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF10">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16515">
        <property type="entry name" value="HIP1_clath_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="9">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="10">
        <location>
            <begin position="688"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="921"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="266"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="480"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="874"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="972" mass="108705" checksum="12D76DB205496970" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3F1</accession>
    <name>A0A5F8G3F1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger C3HC-type containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZC3HC1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3F1"/>
    <dbReference type="Ensembl" id="ENSMODT00000085374.1">
        <property type="protein sequence ID" value="ENSMODP00000041961.1"/>
        <property type="gene ID" value="ENSMODG00000014630.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006086"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014630">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="8">
        <location>
            <begin position="73"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="9">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="9">
        <location>
            <begin position="350"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="448" mass="49595" checksum="00AA66CD4856A63D" modified="2019-12-11" version="1">MESPSPAPVVAAGEEKTRSSGVRSSEVTPQKIRQLIDEGIAPEEGGSDAKDTSALSQPINGSPQAEQPPFESTSKEAFFSRVETFTISFSGKPHDLSPLVCAKYGWVTVECDMLRCSSCQAFLCASLQPAFDFERYNERCTELKKALCTAHEKFCFWPDSPCPDRFGVLLVDEPVALLNDFIDRFQSLCRLDLQLPSLRPDDLKNMCLSEDKVSLLLHLIEDELEHRTDGEKGTDGEKGTDGEKGTDGEKAPAKSGSDIQIHVTACILALCGWSCSSSVESVQLSLIACSHCLRKVGLWGFQQIESALVDLDVTFGLMSTPIAVPDGRSERFPLALVSPRRMMTRSQDATFSPSSEQDTSVKSVFDPISQHRDWCPWVNSTQVKEAKEEKENELDTCRPTEPGWKAVLHILLTHQQSNLPGDSDSTNLSEKSRKVFRIFRQWESMCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3F2</accession>
    <name>A0A5F8G3F2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Lysine-specific demethylase 5A</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Histone demethylase JARID1A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Jumonji/ARID domain-containing protein 1A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Retinoblastoma-binding protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">[histone H3]-trimethyl-L-lysine(4) demethylase 5A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">KDM5A</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="Ensembl" id="ENSMODT00000074429.1">
        <property type="protein sequence ID" value="ENSMODP00000041982.1"/>
        <property type="gene ID" value="ENSMODG00000018390.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157170"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018390">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16873">
        <property type="entry name" value="ARID_KDM5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15602">
        <property type="entry name" value="PHD1_KDM5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15606">
        <property type="entry name" value="PHD2_KDM5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000368">
        <property type="entry name" value="Lysine demethylase 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000613">
        <property type="entry name" value="lysine-specific demethylase 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000035">
        <property type="entry name" value="PHD transcription factor Rum1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000001">
        <property type="entry name" value="Putative lysine-specific demethylase 5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000001">
        <property type="entry name" value="Putative lysine-specific demethylase 5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047974">
        <property type="entry name" value="KDM5A_ARID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047973">
        <property type="entry name" value="KDM5A_PHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047970">
        <property type="entry name" value="KDM5A_PHD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF17">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="26" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="30">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="29">
        <location>
            <begin position="84"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="28">
        <location>
            <begin position="247"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="31">
        <location>
            <begin position="391"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="28">
        <location>
            <begin position="1116"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1282"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1362"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="26">
        <location>
            <begin position="1496"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="27">
        <location>
            <begin position="1292"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00080580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1583" mass="180224" checksum="E3C80AADA5F38DFF" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3F4</accession>
    <name>A0A5F8G3F4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cystatin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CST3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3F4"/>
    <dbReference type="FunCoup" id="A0A5F8G3F4">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042008"/>
    <dbReference type="Ensembl" id="ENSMODT00000067880.1">
        <property type="protein sequence ID" value="ENSMODP00000042008.1"/>
        <property type="gene ID" value="ENSMODG00000048042.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154755"/>
    <dbReference type="InParanoid" id="A0A5F8G3F4"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000048042">
        <property type="expression patterns" value="Expressed in placenta and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000004">
        <property type="entry name" value="Cystatin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186:SF2">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023873766" evidence="5">
        <location>
            <begin position="25"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="6">
        <location>
            <begin position="29"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="144" mass="15844" checksum="76168AC1A7C72EB4" modified="2019-12-11" version="1">MAGSRLSLVLLPLLLIALVCAVHAERKPRLVGGITEANENEEGVQRAVNFAISEYNKASNDKFGHRIVRVVRAQKQLVAGIKYILEVEISRTTCTKSVTDFSSCPLHEDPTLKKDKKGAVTLGWFSSSHNLSHNLPPEIPKDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3F5</accession>
    <name>A0A5F8G3F5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP-binding protein TrmE N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3F5"/>
    <dbReference type="Ensembl" id="ENSMODT00000053601.1">
        <property type="protein sequence ID" value="ENSMODP00000041994.1"/>
        <property type="gene ID" value="ENSMODG00000015098.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016851"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015098">
        <property type="expression patterns" value="Expressed in placenta and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000007">
        <property type="entry name" value="tRNA modification GTPase GTPBP3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="7">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="203" mass="20955" checksum="6765B0E25AB99CAA" modified="2019-12-11" version="1">MWRRLGTLVSGSGQNTGLYARLPKRRRSCPPVSGGRATIFALSSGQGKCGVAVIRTSGPASGPAVLGLAALRALPQPRLAKLRLLKHPVSSEPLDRGLVLWFPGPHSFTGEDCAEFHVHGGPAVVSAVLGALGRRRPGLSAGRGRRVHQEGLPEWEAEPDRGGGAGRPDPRRDGGPAAPGPEAAPGRAGPALPSLGRDPDHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3F6</accession>
    <name>A0A5F8G3F6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Transient receptor potential cation channel subfamily V member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TRPV2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3F6"/>
    <dbReference type="Ensembl" id="ENSMODT00000077938.1">
        <property type="protein sequence ID" value="ENSMODP00000041966.1"/>
        <property type="gene ID" value="ENSMODG00000011239.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158512"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011239">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000018">
        <property type="entry name" value="Transient receptor potential cation channel subfamily V member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008347">
        <property type="entry name" value="TrpV1-4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00870">
        <property type="entry name" value="trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF5">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01768">
        <property type="entry name" value="TRPVRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="413"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="729"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000041966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="757" mass="85468" checksum="2015055AD3EF8E3C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3F9</accession>
    <name>A0A5F8G3F9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho guanine nucleotide exchange factor 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3F9"/>
    <dbReference type="Ensembl" id="ENSMODT00000080037.1">
        <property type="protein sequence ID" value="ENSMODP00000042013.1"/>
        <property type="gene ID" value="ENSMODG00000018631.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160622"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018631">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01224">
        <property type="entry name" value="PH_Collybistin_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11973">
        <property type="entry name" value="SH3_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000002">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000015">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="143"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="239"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="454"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="647" mass="75177" checksum="1FBF09412EC94AF5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4C3</accession>
    <name>A0A5F8G4C3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MAGUK p55 subfamily member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">MPP7</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterodimer; able to heterodimerize via its C-terminal L27 domain with LIN7A, LIN7B and LIN7C. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with DLG1 via its N-terminal L27 domain. Interacts with PALS1 and PATJ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Lateral cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4C3"/>
    <dbReference type="FunCoup" id="A0A5F8G4C3">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042285"/>
    <dbReference type="Ensembl" id="ENSMODT00000072665.1">
        <property type="protein sequence ID" value="ENSMODP00000042285.1"/>
        <property type="gene ID" value="ENSMODG00000008195.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156232"/>
    <dbReference type="InParanoid" id="A0A5F8G4C3"/>
    <dbReference type="OMA" id="ECILECV"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008195">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097025">
        <property type="term" value="C:MPP7-DLG1-LIN7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031334">
        <property type="term" value="P:positive regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071896">
        <property type="term" value="P:protein localization to adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06799">
        <property type="entry name" value="PDZ_MPP3-MPP4-MPP7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12033">
        <property type="entry name" value="SH3_MPP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000159">
        <property type="entry name" value="MAGUK p55 subfamily member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000046">
        <property type="entry name" value="MAGUK p55 subfamily member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000757">
        <property type="entry name" value="MAGUK p55 subfamily member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035599">
        <property type="entry name" value="MPP7_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 17" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0796">Tight junction</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="22">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="21">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="265"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="20">
        <location>
            <begin position="405"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="613" mass="70122" checksum="2CCCB00AE3FFDF90" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4C9</accession>
    <name>A0A5F8G4C9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tower domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000073981.1">
        <property type="protein sequence ID" value="ENSMODP00000042289.1"/>
        <property type="gene ID" value="ENSMODG00000009516.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003602"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009516">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04493">
        <property type="entry name" value="BRCA2DBD_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04494">
        <property type="entry name" value="BRCA2DBD_OB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000205">
        <property type="entry name" value="Breast cancer susceptibility protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048262">
        <property type="entry name" value="BRCA2_OB_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015188">
        <property type="entry name" value="BRCA2_OB_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055077">
        <property type="entry name" value="BRCA2_TR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015205">
        <property type="entry name" value="Tower_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09104">
        <property type="entry name" value="BRCA-2_OB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22687">
        <property type="entry name" value="BRCA2_TR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21318">
        <property type="entry name" value="BRCA2DBD_OB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09121">
        <property type="entry name" value="Tower"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002397">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01341">
        <property type="entry name" value="Tower"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81878">
        <property type="entry name" value="BRCA2 tower domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tower" evidence="8">
        <location>
            <begin position="2775"/>
            <end position="2816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1311"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2373"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3139"/>
            <end position="3162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3201"/>
            <end position="3221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2796"/>
            <end position="2823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1327"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2373"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="3139"/>
            <end position="3152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="3293" mass="370594" checksum="CE4270378406C382" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4D0</accession>
    <name>A0A5F8G4D0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cullin 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000060380.1">
        <property type="protein sequence ID" value="ENSMODP00000042311.1"/>
        <property type="gene ID" value="ENSMODG00000018990.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153954"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018990">
        <property type="expression patterns" value="Expressed in cerebellum and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056405">
        <property type="entry name" value="ARM_CUL7_CUL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021097">
        <property type="entry name" value="CPH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055486">
        <property type="entry name" value="CUL7/CUL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22771:SF4">
        <property type="entry name" value="CULLIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22771">
        <property type="entry name" value="CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24742">
        <property type="entry name" value="ARM_CUL7_CUL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11515">
        <property type="entry name" value="Cul7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23168">
        <property type="entry name" value="CUL7_CUL9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="8">
        <location>
            <begin position="828"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="1215"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1114"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1332"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1340"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1353"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1369" mass="152339" checksum="8792FE7B22B0C0ED" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4D3</accession>
    <name>A0A5F8G4D3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/arginine repetitive matrix 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SRRM2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="FunCoup" id="A0A5F8G4D3">
        <property type="interactions" value="1238"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042294"/>
    <dbReference type="Ensembl" id="ENSMODT00000077295.1">
        <property type="protein sequence ID" value="ENSMODP00000042294.1"/>
        <property type="gene ID" value="ENSMODG00000016533.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161127"/>
    <dbReference type="InParanoid" id="A0A5F8G4D3"/>
    <dbReference type="OMA" id="QQCIIHY"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016533">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070742">
        <property type="term" value="F:C2H2 zinc finger domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21375">
        <property type="entry name" value="cwf21_SRRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047490">
        <property type="entry name" value="SRRM2_cwf21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052109">
        <property type="entry name" value="SRRM_Domain-Containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755:SF3">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt5 C-terminal" evidence="4">
        <location>
            <begin position="622"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="4">
        <location>
            <begin position="738"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1483"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2439"/>
            <end position="2886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="822"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="916"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1129"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1150"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1196"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1267"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1307"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1321"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1561"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1580"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1608"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1622"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1661"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1720"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1745"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1790"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1818"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1878"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1907"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1929"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1943"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1981"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2180"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2207"/>
            <end position="2234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2589"/>
            <end position="2598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2642"/>
            <end position="2658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2665"/>
            <end position="2698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2739"/>
            <end position="2780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="2783"/>
            <end position="2800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2801"/>
            <end position="2821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2840"/>
            <end position="2860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2921" mass="317709" checksum="D10536AEBB0274A0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4D4</accession>
    <name>A0A5F8G4D4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand calcium binding domain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EFCAB2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007481584.1">
        <property type="nucleotide sequence ID" value="XM_007481522.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4D4"/>
    <dbReference type="Ensembl" id="ENSMODT00000052950.1">
        <property type="protein sequence ID" value="ENSMODP00000042316.1"/>
        <property type="gene ID" value="ENSMODG00000041630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100026967"/>
    <dbReference type="CTD" id="68226"/>
    <dbReference type="GeneTree" id="ENSGT00940000160590"/>
    <dbReference type="OrthoDB" id="10260307at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000041630">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46763">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46763:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="162" mass="18585" checksum="D247E562D2926095" modified="2019-12-11" version="1">MAEEKDNGDAGLLELQKKIKEAFEVFDHESNDTVDVREIGTIIRSLGCCPSEGELHDLIAEVEEEEPTGYIRLETFLPMMVKVLKERRYRPVPEDVLLQAFEVLDTAKGGFLTKEDLVRYMTEEGEPFTQEEMEEMLSAALDPDTNTIQYRDYLAMMVIDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4D6</accession>
    <name>A0A5F8G4D6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4D6"/>
    <dbReference type="Ensembl" id="ENSMODT00000087470.1">
        <property type="protein sequence ID" value="ENSMODP00000042312.1"/>
        <property type="gene ID" value="ENSMODG00000041184.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182805"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000041184">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF55">
        <property type="entry name" value="ALPHA-ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="74"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="299"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="386" mass="42429" checksum="60522CD078E50441" modified="2019-12-11" version="1">GKSLNPYFLALTKMNVVEQDHIDKFMIELDGTENKSKFGANAILGVSLAVCKAGAAERCIPLYRHIADLACKEDLILPVPAFNVINGGSHAGNKLAMQEFMILPIGAPSFKEAMRIGTEVYHNLKNVIKEKYGQIATSVGDEGGFAPNILENKEALDLLKEAISKAGYTDEVVIGMDIAASEFRRDGKYDLDFKSPDDPSRYVTAKDLMDMYKSFIKDYPVVSIEDPFDQDDWEPWTTFTADAGIQVVGDDLTVTNPSRIKKAIQEKSCNCLLLKVNQIGTVTEAIKMAQANGWGVMVSHRSGETEDSFIADLVVGLSTGQIKTGAPCRSERLAKYNQLLRIEEQLGCKAKFAGKNFRNPGVICQKGSSPKITTLAIFMCHVKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4D8</accession>
    <name>A0A5F8G4D8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-protein ligase E3C</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">HECT-type ubiquitin transferase E3C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RTA-associated ubiquitin ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">UBE3C</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with 26S proteasomes. Interacts (via the HECT domain) with UBE2D1 and, less efficiently, with UBE2L3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UBE3C family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4D8"/>
    <dbReference type="Ensembl" id="ENSMODT00000082881.1">
        <property type="protein sequence ID" value="ENSMODP00000042299.1"/>
        <property type="gene ID" value="ENSMODG00000005239.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156321"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005239">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000014">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="696"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1035" mass="118829" checksum="BC3272553E2F7BD3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4D9</accession>
    <name>A0A5F8G4D9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRELI domain containing 3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PRELID3B</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4D9"/>
    <dbReference type="Ensembl" id="ENSMODT00000079712.1">
        <property type="protein sequence ID" value="ENSMODP00000042338.1"/>
        <property type="gene ID" value="ENSMODG00000016608.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182810"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016608">
        <property type="expression patterns" value="Expressed in endometrium and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="153" mass="16812" checksum="716855DEE7CA2E76" modified="2019-12-11" version="1">HPWETVTTAAMQKYPNPMNPSVVGVDVLARHIDPTGKLHSHRLLSTEWGMPSIVKSISFTNLVSVDERLIYKPHPQEPGKTILTQEAIITVKGVSLSSYLEGLMESTISSNANKGREAMEWVINKLNAEIEELTASARGSMRTPMAAAAFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4E0</accession>
    <name>A0A5F8G4E0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Synaptotagmin 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SYT9</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4E0"/>
    <dbReference type="Ensembl" id="ENSMODT00000086275.1">
        <property type="protein sequence ID" value="ENSMODP00000042317.1"/>
        <property type="gene ID" value="ENSMODG00000006099.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155948"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006099">
        <property type="expression patterns" value="Expressed in cerebellum and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08403">
        <property type="entry name" value="C2B_Synaptotagmin-3-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000005">
        <property type="entry name" value="Synaptotagmin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000011">
        <property type="entry name" value="Synaptotagmin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF180">
        <property type="entry name" value="SYNAPTOTAGMIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="184"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="316"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="454" mass="52111" checksum="823E328B903ADE97" modified="2019-12-11" version="1">MKNYTDFMLTNSQDISVSLLSLVVTACGLALFSVSLFVSWKLCWIPWRERGLFSGSKDNQEPLNYTETETNDPEYSEDYQEQPSPYPDAAMKISHTSPDIPLASQAENKENCVHGARMQRQVTEPTPSARHNSIRRQLNLSNPDFNVQQLQKQEQLTGIGRIKPELYKQRSVDTDDGRKSNSKACGKLNFIVKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFPVPYNDLAMRKLHFSVYDFDRFSRHDLIGQVVVDHFLELADFPRECILWKDIEYVTNENVDLGDLMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGKRLKKRKTSTKRNTLNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIGVCQVGNEAERLGRDHWSEMLSYPRKPIAHWHPLVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4E1</accession>
    <name>A0A5F8G4E1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Centrosomal protein of 41 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CEP41</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Found in a complex with TTLL6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CEP41 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056655683.1">
        <property type="nucleotide sequence ID" value="XM_056799705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4E1"/>
    <dbReference type="Ensembl" id="ENSMODT00000078353.1">
        <property type="protein sequence ID" value="ENSMODP00000042305.1"/>
        <property type="gene ID" value="ENSMODG00000014526.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100015758"/>
    <dbReference type="CTD" id="95681"/>
    <dbReference type="GeneTree" id="ENSGT00390000002222"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014526">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000012">
        <property type="entry name" value="Centrosomal protein of 41 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051889">
        <property type="entry name" value="CEP41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rhodanese" evidence="15">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="350" mass="39450" checksum="28DA33ACDF004754" modified="2019-12-11" version="1">MSSRGHIGDPEFLTKRIPQNPKYQHVKTRLDTGNSMTKYTEKLEEIKKNYRYKKDELFKRLKVTTFAQLVIQVASLSDQPLEVTAEEIQRLEDHNTALAIPDADDKINGKGSPTEKPPSPIQFISNAGAGEGCRSTLQSVISGVGELDLDKESLKKTEPNTKDKPYPDCPFLLLDVRDKDSYNQCHIVGAYSYPIATLSRTMNPYSNDILEYKNAHGKIIILYDDDERLASQAATTMCERGFENLFMLSGGLKVLAQKFPEGLITGSLPVNCQQAPPPGSARKRSSPRAQTQYAENKWRFSPEDLKKIEYYLEEEQVPLETPGLGIRKIQDTMKKAGQERLQKKGQELSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4E3</accession>
    <name>A0A5F8G4E3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PALM2 and AKAP2 fusion</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4E3"/>
    <dbReference type="Ensembl" id="ENSMODT00000078236.1">
        <property type="protein sequence ID" value="ENSMODP00000042343.1"/>
        <property type="gene ID" value="ENSMODG00000004809.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100533101"/>
    <dbReference type="CTD" id="445815"/>
    <dbReference type="GeneTree" id="ENSGT00940000161837"/>
    <dbReference type="OrthoDB" id="9941155at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004809">
        <property type="expression patterns" value="Expressed in heart and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004965">
        <property type="entry name" value="Paralemmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10498:SF10">
        <property type="entry name" value="PALM2 AND AKAP2 FUSION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10498">
        <property type="entry name" value="PARALEMMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03285">
        <property type="entry name" value="Paralemmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="425"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="668"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="759"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="878"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="668"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1021" mass="112759" checksum="B858421C7DD724F1" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4E4</accession>
    <name>A0A5F8G4E4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amyloid beta protein binding family B member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">APBB2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_001373407.3">
        <property type="nucleotide sequence ID" value="XM_001373370.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056658537.1">
        <property type="nucleotide sequence ID" value="XM_056802559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4E4"/>
    <dbReference type="FunCoup" id="A0A5F8G4E4">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042322"/>
    <dbReference type="Ensembl" id="ENSMODT00000081483.1">
        <property type="protein sequence ID" value="ENSMODP00000042322.1"/>
        <property type="gene ID" value="ENSMODG00000020566.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021174"/>
    <dbReference type="KEGG" id="mdo:100021174"/>
    <dbReference type="CTD" id="323"/>
    <dbReference type="GeneTree" id="ENSGT00390000000002"/>
    <dbReference type="InParanoid" id="A0A5F8G4E4"/>
    <dbReference type="OMA" id="NVPHADD"/>
    <dbReference type="OrthoDB" id="5969782at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020566">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036438">
        <property type="term" value="P:maintenance of lens transparency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901988">
        <property type="term" value="P:negative regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006939">
        <property type="term" value="P:smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01272">
        <property type="entry name" value="PTB1_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01271">
        <property type="entry name" value="PTB2_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000019">
        <property type="entry name" value="Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000003">
        <property type="entry name" value="amyloid beta A4 precursor protein-binding family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000034">
        <property type="entry name" value="amyloid beta A4 precursor protein-binding family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF11">
        <property type="entry name" value="AMYLOID BETA PRECURSOR PROTEIN BINDING FAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="430"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="600"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="769" mass="84534" checksum="BF01B821E7542071" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4E6</accession>
    <name>A0A5F8G4E6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Presenilin</fullName>
            <ecNumber evidence="21">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PSEN1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Endoplasmic reticulum membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Golgi apparatus membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="21">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the peptidase A22A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="21"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4E6"/>
    <dbReference type="Ensembl" id="ENSMODT00000076720.1">
        <property type="protein sequence ID" value="ENSMODP00000042348.1"/>
        <property type="gene ID" value="ENSMODG00000006792.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158751"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006792">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042987">
        <property type="term" value="P:amyloid precursor protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000001">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002031">
        <property type="entry name" value="Pept_A22A_PS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF18">
        <property type="entry name" value="PRESENILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01073">
        <property type="entry name" value="PRESENILIN1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 21" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 21" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0770">Synapse</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="383" mass="43450" checksum="B28A0EE3766451B1" modified="2019-12-11" version="1">NDGRERQRHEHSERRRHGNNSEAETNGQPQGGTRQVVENDDEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAMDYITLALMIWNFGMVGMICIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISIYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSNYNAQRGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4E7</accession>
    <name>A0A5F8G4E7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4E7"/>
    <dbReference type="Ensembl" id="ENSMODT00000063783.1">
        <property type="protein sequence ID" value="ENSMODP00000042310.1"/>
        <property type="gene ID" value="ENSMODG00000040895.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154939"/>
    <dbReference type="OMA" id="LMIAEFN"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000040895">
        <property type="expression patterns" value="Expressed in cerebellum and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000001">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000002">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF185">
        <property type="entry name" value="ANKYRIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="416"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="469" mass="50752" checksum="8AC4885FCA2A6496" modified="2019-12-11" version="1">KKERKKERKKERKKERKKGRKEGRKEGSYLRAARAGNLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELIHRDANVDAATKKGNTALHIASLAGQTEVVKVLATNGANLNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDSNADVESKSGFTPLHIAAHYGNINVATLLLNRGAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKILLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHANIVSQLMHHGASPNTTNVRKNETCDLILPSISHSCSHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4E9</accession>
    <name>A0A5F8G4E9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="11">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PLCZ1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4E9"/>
    <dbReference type="Ensembl" id="ENSMODT00000074808.1">
        <property type="protein sequence ID" value="ENSMODP00000042314.1"/>
        <property type="gene ID" value="ENSMODG00000017890.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159950"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017890">
        <property type="expression patterns" value="Expressed in spermatid and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF29">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0278">Fertilization</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="14">
        <location>
            <begin position="277"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="393"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="554" mass="63974" checksum="6D266FE617C51946" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUG1</accession>
    <name>A0A5F8GUG1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27429"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27430"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUG1"/>
    <dbReference type="Ensembl" id="ENSMODT00000072081.1">
        <property type="protein sequence ID" value="ENSMODP00000051137.1"/>
        <property type="gene ID" value="ENSMODG00000000676.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160046"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000676">
        <property type="expression patterns" value="Expressed in spermatid and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF62">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE LPIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="6">
        <location>
            <begin position="425"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="636" mass="70840" checksum="6521BB5D6C3CE4BB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUG2</accession>
    <name>A0A5F8GUG2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RING-type E3 ubiquitin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RNF157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">E3 ubiquitin ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUG2"/>
    <dbReference type="Ensembl" id="ENSMODT00000071782.1">
        <property type="protein sequence ID" value="ENSMODP00000050851.1"/>
        <property type="gene ID" value="ENSMODG00000008340.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009925"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008340">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16817">
        <property type="entry name" value="mRING-HC-C3HC5_RNF157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase MGRN1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058981">
        <property type="entry name" value="MGRN1/RNF157-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF1">
        <property type="entry name" value="E3 UBIQUITIN LIGASE RNF157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26192">
        <property type="entry name" value="RNF157-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="392"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="441"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="652" mass="71143" checksum="A4F73C11A6AC0440" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUG5</accession>
    <name>A0A5F8GUG5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase like 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">METTL25</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUG5"/>
    <dbReference type="Ensembl" id="ENSMODT00000062048.1">
        <property type="protein sequence ID" value="ENSMODP00000051142.1"/>
        <property type="gene ID" value="ENSMODG00000020485.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063745"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020485">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF9">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="321"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="563" mass="63346" checksum="C43F7B45647C774C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUG6</accession>
    <name>A0A5F8GUG6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane protein 237</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TMEM237</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transition zone in primary cilia. Required for ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM237 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUG6"/>
    <dbReference type="Ensembl" id="ENSMODT00000061033.1">
        <property type="protein sequence ID" value="ENSMODP00000050989.1"/>
        <property type="gene ID" value="ENSMODG00000015258.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005159"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015258">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029409">
        <property type="entry name" value="TMEM237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15383">
        <property type="entry name" value="TMEM237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="388" mass="43386" checksum="ED663222BAEF2EEA" modified="2019-12-11" version="1">MSPGPPQEEPIPRPPRALPPVPSTQQDDIPLNRPKKKKLKPKNALGSASPEDIIQDTGHEPSNSREPLTHESLEHLDAPVQRKRKKKRLPIESETSFTPKSPPNTALFLNENGMDLEQADEPVPRKPRKRTKRSQPTALHYTNELGVEEEDIIADEQNHPEQQPSVFTAPMGVSQPVGKVFVEKSRRFQAADRSELIKTTENVDMLMDIKPSWTTRDVALSVHRGFRMIGLFSHGFLAGYAVWNIIVIYVLAGKQLSDLSNFLQQYKSLAYPAQSLLYLLLAISTISAFDRIDFAKTSVAIRGFLALDPTALASFLYFAALILSLSQQMTSDRIHLYTPATVNGSLWVAGTEEQILHPWIVVNLVVALLVGLSWLFLSYRPEKDLSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUG7</accession>
    <name>A0A5F8GUG7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oligophrenin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">OPHN1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUG7"/>
    <dbReference type="Ensembl" id="ENSMODT00000086498.1">
        <property type="protein sequence ID" value="ENSMODP00000050856.1"/>
        <property type="gene ID" value="ENSMODG00000047154.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160157"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000047154">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000008">
        <property type="entry name" value="Rho GTPase-activating protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000074">
        <property type="entry name" value="Rho GTPase-activating protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047234">
        <property type="entry name" value="GRAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552">
        <property type="entry name" value="OLIGOPHRENIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552:SF2">
        <property type="entry name" value="OLIGOPHRENIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="114"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="533" mass="59639" checksum="62BB9B2F1726494D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUG9</accession>
    <name>A0A5F8GUG9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protocadherin gamma subfamily C, 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PCDHGC5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUG9"/>
    <dbReference type="Ensembl" id="ENSMODT00000054575.1">
        <property type="protein sequence ID" value="ENSMODP00000051288.1"/>
        <property type="gene ID" value="ENSMODG00000010717.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162232"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010717">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032455">
        <property type="entry name" value="Cadherin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031904">
        <property type="entry name" value="Cadherin_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF234">
        <property type="entry name" value="PROTOCADHERIN GAMMA-A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16492">
        <property type="entry name" value="Cadherin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15974">
        <property type="entry name" value="Cadherin_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023941473" evidence="15">
        <location>
            <begin position="30"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="134"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="243"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="348"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="453"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="579"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="812"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="909"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="934" mass="102142" checksum="0368AFD85B95585A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUH2</accession>
    <name>A0A5F8GUH2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine rich repeat containing 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LRRC28</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUH2"/>
    <dbReference type="Ensembl" id="ENSMODT00000069973.1">
        <property type="protein sequence ID" value="ENSMODP00000050994.1"/>
        <property type="gene ID" value="ENSMODG00000012729.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157771"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012729">
        <property type="expression patterns" value="Expressed in spermatid and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF12">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="273" mass="30895" checksum="4D276B1FBB5504C1" modified="2019-12-11" version="1">KLPVYGKCSTKEVKLKNWRSWRVQAYPFTLKPEDLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRSLRHLRLANNQLKFLPPDLGRSRELQYVYVDNNIHLKGLPSYLYNKVIGCSGCGSPIQVSEVKLLSFSSGQLTVFLPSEVKSIGTETDHVLPLQELAMRSLYNAYYKFIKDLNFLSPISLPKSLLELLHCPLGHCHRCSEPMFTIVYPKLFPLRETPMAGLHQGRTTVSFVAYCCSTQCLRTFDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUH6</accession>
    <name>A0A5F8GUH6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Muscular LMNA interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MLIP</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUH6"/>
    <dbReference type="Ensembl" id="ENSMODT00000083209.1">
        <property type="protein sequence ID" value="ENSMODP00000050866.1"/>
        <property type="gene ID" value="ENSMODG00000018791.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015862"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018791">
        <property type="expression patterns" value="Expressed in heart and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029331">
        <property type="entry name" value="MLIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31514:SF1">
        <property type="entry name" value="MUSCULAR LMNA-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31514">
        <property type="entry name" value="MUSCULAR LMNA-INTERACTING PROTEIN MLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15274">
        <property type="entry name" value="MLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="918" mass="99349" checksum="8D677FC31645F880" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUH8</accession>
    <name>A0A5F8GUH8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="23">LDL receptor related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LRP2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endosome lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <location evidence="17">Coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUH8"/>
    <dbReference type="Ensembl" id="ENSMODT00000065662.1">
        <property type="protein sequence ID" value="ENSMODP00000051157.1"/>
        <property type="gene ID" value="ENSMODG00000007996.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157232"/>
    <dbReference type="OMA" id="NRHCVGR"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007996">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031904">
        <property type="term" value="C:endosome lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000001">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000011">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000045">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000112">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000147">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000159">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF11">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0168">Coated pit</keyword>
    <keyword evidence="13 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023901928" evidence="21">
        <location>
            <begin position="25"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="432"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="475"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="655"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="699"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="850"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="884"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="891"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="903"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="926"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="945"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="973"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="985"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1024"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1088"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1095"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1107"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1179" mass="131111" checksum="CF6821AF0701E529" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUH9</accession>
    <name>A0A5F8GUH9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CLK4 associating serine/arginine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CLASRP</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUH9"/>
    <dbReference type="Ensembl" id="ENSMODT00000086020.1">
        <property type="protein sequence ID" value="ENSMODP00000051200.1"/>
        <property type="gene ID" value="ENSMODG00000020854.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153892"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020854">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161:SF4">
        <property type="entry name" value="CLK4-ASSOCIATING SERINE_ARGININE RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01141">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of white apricot N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="630" mass="72197" checksum="AD82FB5D899AC2F4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUI0</accession>
    <name>A0A5F8GUI0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 2 member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC2A6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUI0"/>
    <dbReference type="Ensembl" id="ENSMODT00000081929.1">
        <property type="protein sequence ID" value="ENSMODP00000051298.1"/>
        <property type="gene ID" value="ENSMODG00000012985.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159976"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012985">
        <property type="expression patterns" value="Expressed in cerebellum and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF59">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="40"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="444" mass="48889" checksum="526D88887BD7DCB8" modified="2019-12-11" version="1">MEQPLLRSETPDYETFSEKSEQEQEQNYIRTLKNKRLFLATFAAVLGNFSFGYALVYTSPVIPALERSPNPALRMNKTESSWFGSVFTLGAAAGGLSAMVLNDLLGRKLSIMFSAVPSVIGYALMAGAQGLWMLLLGRTLTGFAGGLTAACIPVYVSEISHPGVRGALGATPQIMAVFGSLLLYALGLKVPWRWLAVAGEVPVVVMMVLLCFMPNSPRFLLSQGKEEEALEALAWLRGRDTDFHREFQQIQNSVQQQSSRLSWAELRDPFIYKPIAIAVLMRFLQQLTGVTPILVYLQSIFHSTAVLLPAEEDAAIVGAVRLVSVLIAATTMDKAGRKILLFVSGYAMGWGPITWLLMSEILPLKARGVASGLCVLVSWLTAFVLTKSFLLVVNAFGLQVPFYFFAAICLVNLVFTGCCVPETRRRSLEQIESFFRTGRKSFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUI2</accession>
    <name>A0A5F8GUI2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450 3A</fullName>
            <ecNumber evidence="15">1.14.14.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.-" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUI2"/>
    <dbReference type="Ensembl" id="ENSMODT00000084733.1">
        <property type="protein sequence ID" value="ENSMODP00000051004.1"/>
        <property type="gene ID" value="ENSMODG00000044972.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182958"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000044972">
        <property type="expression patterns" value="Expressed in liver and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd20650">
        <property type="entry name" value="CYP3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000096">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008072">
        <property type="entry name" value="Cyt_P450_E_CYP3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF38">
        <property type="entry name" value="CYTOCHROME P450 3A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01689">
        <property type="entry name" value="EP450IICYP3A"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="500" mass="57465" checksum="B19D3E9248DFF064" modified="2019-12-11" version="1">MSHEESLEVTLWHLDLSKPSLALRYFIYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVLAIMDPETIKTVLVKECYSVFTNRRMFGPSGFLEKAISIAKDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEAEKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIKKLIRFSFLDPLILSTTIFPFLIPLFNKLDITVFPKEATDFLAKSIIKIKEERTKSTEKHRVDFLQLMMDSQTSKNSDDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQEKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPEPEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQAELRNKKGNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUI3</accession>
    <name>A0A5F8GUI3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kelch domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KLHDC2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUI3"/>
    <dbReference type="Ensembl" id="ENSMODT00000067908.1">
        <property type="protein sequence ID" value="ENSMODP00000051162.1"/>
        <property type="gene ID" value="ENSMODG00000011565.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157150"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011565">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140627">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the C-end degron rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000012">
        <property type="entry name" value="Kelch domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF3">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="366" mass="41344" checksum="BF397C88A00FBF98" modified="2019-12-11" version="1">MADGEEEELQVAEPPPGPGPGLGAADQESLELLEAATPAERSGHVAVSDGRHMLVWGGYKNAQVRGFYDFYLPRDEIWIYNMETGRWTKKNTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDKVLQWVRVDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKQLGTFEFDETSFWNSSHPRGWNDHVHVLDTETFTWRQPITTGKSPSPRAAHACATVGNKGFVFGGRYRDSRMNDLHYLNLDTWEWNELIPQGLCPVGRSWHSLTPVSPDHLFLFGGFTTDKQPLSDAWTYWINKNEWIQFKHSYAEKPRLWHTACTSDEGEVIVFGGCANNLLAQHKAAKPRSSHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUI4</accession>
    <name>A0A5F8GUI4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Erythrocyte membrane protein band 4.1 like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EPB41L3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUI4"/>
    <dbReference type="Ensembl" id="ENSMODT00000062040.1">
        <property type="protein sequence ID" value="ENSMODP00000051205.1"/>
        <property type="gene ID" value="ENSMODG00000021459.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157047"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021459">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13184">
        <property type="entry name" value="FERM_C_4_1_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17203">
        <property type="entry name" value="FERM_F1_EPB41L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000002">
        <property type="entry name" value="Erythrocyte protein band 4.1-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030691">
        <property type="entry name" value="Band4.1-L3_FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008379">
        <property type="entry name" value="Band_4.1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007477">
        <property type="entry name" value="SAB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF20">
        <property type="entry name" value="BAND 4.1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05902">
        <property type="entry name" value="4_1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04382">
        <property type="entry name" value="SAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002304">
        <property type="entry name" value="Membrane_skeletal_4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="113"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="698"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="868"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="975"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1001"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1155" mass="128754" checksum="1FDBA39C673C503B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUI5</accession>
    <name>A0A5F8GUI5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="30">Myosin IXA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">MYO9A</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000061324.1">
        <property type="protein sequence ID" value="ENSMODP00000051303.1"/>
        <property type="gene ID" value="ENSMODG00000001934.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154905"/>
    <dbReference type="OMA" id="INDYRSM"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001934">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034330">
        <property type="term" value="P:cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01385">
        <property type="entry name" value="MYSc_Myo9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17216">
        <property type="entry name" value="RA_Myosin-IXa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000003">
        <property type="entry name" value="Putative unconventional myosin-IXa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000008">
        <property type="entry name" value="Putative unconventional myosin-IXa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000003">
        <property type="entry name" value="unconventional myosin-IXa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000005">
        <property type="entry name" value="unconventional myosin-IXa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000121">
        <property type="entry name" value="unconventional myosin-IXa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000013">
        <property type="entry name" value="unconventional myosin-IXa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000009">
        <property type="entry name" value="unconventional myosin-IXb isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046987">
        <property type="entry name" value="Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036023">
        <property type="entry name" value="MYSc_Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028558">
        <property type="entry name" value="RA_Myosin-IXa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184:SF3">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="23" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 23" id="KW-0505">Motor protein</keyword>
    <keyword evidence="17 23" id="KW-0518">Myosin</keyword>
    <keyword evidence="10 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1634"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1749"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="27">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="29">
        <location>
            <begin position="147"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="26">
        <location>
            <begin position="1454"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="28">
        <location>
            <begin position="1515"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="23">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1178"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1345"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1182"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1356"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="240"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1768" mass="205043" checksum="924C78473766AA86" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUI6</accession>
    <name>A0A5F8GUI6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">ArfGAP with SH3 domain, ankyrin repeat and PH domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ASAP1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_001381441.2">
        <property type="nucleotide sequence ID" value="XM_001381404.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUI6"/>
    <dbReference type="Ensembl" id="ENSMODT00000054816.1">
        <property type="protein sequence ID" value="ENSMODP00000050876.1"/>
        <property type="gene ID" value="ENSMODG00000001522.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100032423"/>
    <dbReference type="KEGG" id="mdo:100032423"/>
    <dbReference type="CTD" id="50807"/>
    <dbReference type="GeneTree" id="ENSGT00940000158547"/>
    <dbReference type="OrthoDB" id="435430at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001522">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08848">
        <property type="entry name" value="ArfGap_ASAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07641">
        <property type="entry name" value="BAR_ASAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13251">
        <property type="entry name" value="PH_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11965">
        <property type="entry name" value="SH3_ASAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000002">
        <property type="entry name" value="arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000004">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.950:FF:000001">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000006">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000012">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000012">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043593">
        <property type="entry name" value="ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037928">
        <property type="entry name" value="ASAP1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038016">
        <property type="entry name" value="ASAP1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037844">
        <property type="entry name" value="PH_ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854:SF2">
        <property type="entry name" value="ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854">
        <property type="entry name" value="ASAP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="19">
        <location>
            <begin position="382"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="20">
        <location>
            <begin position="497"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="658"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="1129"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="772"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="836"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="969"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="793"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="920"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="983"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="994"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1019"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1067"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000050876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1191" mass="131552" checksum="C90800DF2EACBD38" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUI7</accession>
    <name>A0A5F8GUI7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUI7"/>
    <dbReference type="Ensembl" id="ENSMODT00000058103.1">
        <property type="protein sequence ID" value="ENSMODP00000051009.1"/>
        <property type="gene ID" value="ENSMODG00000040895.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154939"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000040895">
        <property type="expression patterns" value="Expressed in cerebellum and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000002">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF185">
        <property type="entry name" value="ANKYRIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="286" mass="30637" checksum="5768AD13D7AC0D5E" modified="2019-12-11" version="1">MAVRPFSFFQSDANASYLRAARAGNLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELIHRDANVDAATKKGNTALHIASLAGQTEVVKVLATNGANLNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDSNADVESKSGFTPLHIAAHYGNINVATLLLNRGAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRVRAEFRIHICIGIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVF2</accession>
    <name>A0A5F8GVF2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger protein 271-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVF2"/>
    <dbReference type="Ensembl" id="ENSMODT00000085569.1">
        <property type="protein sequence ID" value="ENSMODP00000051515.1"/>
        <property type="gene ID" value="ENSMODG00000050100.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154650"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000050100">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050169">
        <property type="entry name" value="Krueppel_C2H2_ZnF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232">
        <property type="entry name" value="KRAB DOMAIN C2H2 ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232:SF168">
        <property type="entry name" value="KRAB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="1">
        <location>
            <begin position="45"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="189" mass="21725" checksum="939B17B019AE0B2C" modified="2019-12-11" version="1">MEDGAPWPWDTAPSLQALAFSQDWSGENEDRMTFEFLTARIQESVTFKDVSVDFTWEEWRHLDPAQRDLYRNVMLENYENLVSVGISVSTVDMISLLEKRDGPWMPEGEVSGAICPDSLNEKSNFEPRDSNRMHTIWMGISSEKSLPKESVVWHSKMKEATGTGSKRSTEITWIMPKEFTGLKIKDQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVF3</accession>
    <name>A0A5F8GVF3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="15">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GPD2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:18978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVF3"/>
    <dbReference type="Ensembl" id="ENSMODT00000055327.1">
        <property type="protein sequence ID" value="ENSMODP00000051623.1"/>
        <property type="gene ID" value="ENSMODG00000004343.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001718"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004343">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="623"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="659"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="694" mass="77513" checksum="EE40540ACD8DC9AB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVF5</accession>
    <name>A0A5F8GVF5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TLE family member 3, transcriptional corepressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TLE3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVF5"/>
    <dbReference type="Ensembl" id="ENSMODT00000071486.1">
        <property type="protein sequence ID" value="ENSMODP00000051487.1"/>
        <property type="gene ID" value="ENSMODG00000009200.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234519"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009200">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000001">
        <property type="entry name" value="transducin-like enhancer protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005617">
        <property type="entry name" value="Groucho/TLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF24">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03920">
        <property type="entry name" value="TLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="11">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="602"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="760" mass="82126" checksum="0CA302423A5EFA48" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVG4</accession>
    <name>A0A5F8GVG4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Telomere length regulation protein TEL2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TELO2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVG4"/>
    <dbReference type="Ensembl" id="ENSMODT00000063335.1">
        <property type="protein sequence ID" value="ENSMODP00000051349.1"/>
        <property type="gene ID" value="ENSMODG00000016164.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006698"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016164">
        <property type="expression patterns" value="Expressed in placenta and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000001">
        <property type="entry name" value="Telomere length regulation protein TEL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000003">
        <property type="entry name" value="Telomere length regulation protein TEL2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057348">
        <property type="entry name" value="TELO2_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25320">
        <property type="entry name" value="TELO2_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TELO2 ARM repeat" evidence="11">
        <location>
            <begin position="324"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="10">
        <location>
            <begin position="470"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="794" mass="89982" checksum="217D56D3139A8979" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVG6</accession>
    <name>A0A5F8GVG6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spermatogenesis-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPATA6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVG6"/>
    <dbReference type="Ensembl" id="ENSMODT00000074258.1">
        <property type="protein sequence ID" value="ENSMODP00000051196.1"/>
        <property type="gene ID" value="ENSMODG00000025440.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063821"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025440">
        <property type="expression patterns" value="Expressed in spermatocyte and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120212">
        <property type="term" value="C:sperm head-tail coupling apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032027">
        <property type="term" value="F:myosin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042769">
        <property type="entry name" value="SPATA6_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032732">
        <property type="entry name" value="SPATA6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16435:SF5">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16435">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 6 SPATA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14909">
        <property type="entry name" value="SPATA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 6 N-terminal" evidence="4">
        <location>
            <begin position="126"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="439" mass="50517" checksum="61ABF1B904ACA29F" modified="2019-12-11" version="1">MGHEVKKPRSEGFKQLHASREHLLRSRTRVTFFVLPYAARAERRTHARPRPHAFQRWKFGSFGFRSNETLFPGGKQRRQKFQLSTRERSRGGRAEGKKPGSSAQRSSVLFQPFPPQLGKMPLEVVVELHIHAITCPGVFLPEKKGLVLGVCIFGQYRETQCFPAVFPLMILEVMKFDKIFVTALDPAAVAELLETYRIRFELIQLIYPDGELLAYYEENTRDFLFPEPRLTPLYPGKDRELLMKTPLGFPGISPKIEFSTMTAIKELSCPLKRLFEERLRQLRPSSASCFKGGFSPQLNALRARTKEDTCERMSKSLRSRSPSPHVIRRLCQEERPVHSSLVSRGLKSLPENKPPFVVRHVDSSKPFGEQIPFKPNTPKSRKKIDFTCFDFPLKRASSLDSMAADLKGVTDPEVDEILERRNPCLRHSPLHEPFEYKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVG7</accession>
    <name>A0A5F8GVG7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of calcineurin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RCAN2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVG7"/>
    <dbReference type="Ensembl" id="ENSMODT00000080804.1">
        <property type="protein sequence ID" value="ENSMODP00000051638.1"/>
        <property type="gene ID" value="ENSMODG00000039825.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159767"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000039825">
        <property type="expression patterns" value="Expressed in heart and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000092">
        <property type="entry name" value="Calcipressin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF5">
        <property type="entry name" value="CALCIPRESSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="186" mass="20916" checksum="66DF06387D6A307B" modified="2019-12-11" version="1">MQGWLKVGKHSSNWLALEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPASPPVGWQPITDATPVINYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKNSPKPKIIQTRRPGLPPPPVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVG8</accession>
    <name>A0A5F8GVG8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase-like 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">METTL26</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0585 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVG8"/>
    <dbReference type="Ensembl" id="ENSMODT00000083124.1">
        <property type="protein sequence ID" value="ENSMODP00000051530.1"/>
        <property type="gene ID" value="ENSMODG00000045646.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010750"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000045646">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010342">
        <property type="entry name" value="DUF938"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974:SF2">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974">
        <property type="entry name" value="UPF0585 PROTEIN CG18661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06080">
        <property type="entry name" value="DUF938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="105" mass="11790" checksum="0ED47617F3C6196F" modified="2019-12-11" version="1">MASAADRNQGPILKVLQQYIDPAQSNFQVLEVASGSGQHVTYFAKAFPKVVWQPTEVDRQCLNRNPAWGLRDVSLLQQLAQASGLFLEKMIDMPANNKCLIFRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVH1</accession>
    <name>A0A5F8GVH1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">malate synthase</fullName>
            <ecNumber evidence="1">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC103097953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVH1"/>
    <dbReference type="Ensembl" id="ENSMODT00000063573.1">
        <property type="protein sequence ID" value="ENSMODP00000051201.1"/>
        <property type="gene ID" value="ENSMODG00000000115.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002932"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000115">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF2">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="8">
        <location>
            <begin position="259"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="9">
        <location>
            <begin position="512"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601465-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="662" mass="73950" checksum="DA4439DE99DC5D5F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVH3</accession>
    <name>A0A5F8GVH3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histone acetyltransferase KAT5</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">60 kDa Tat-interactive protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Histone acetyltransferase HTATIP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Lysine acetyltransferase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Protein 2-hydroxyisobutyryltransferase KAT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Protein acetyltransferase KAT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Protein crotonyltransferase KAT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Protein lactyltransferase KAT5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">KAT5</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61996"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:19466"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:231527"/>
            <dbReference type="ChEBI" id="CHEBI:231528"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:61997"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVH3"/>
    <dbReference type="Ensembl" id="ENSMODT00000070992.1">
        <property type="protein sequence ID" value="ENSMODP00000051535.1"/>
        <property type="gene ID" value="ENSMODG00000009581.6"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162343"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009581">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120300">
        <property type="term" value="F:peptide lactyltransferase (CoA-dependent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18985">
        <property type="entry name" value="CBD_TIP60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000013">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="29">
        <location>
            <begin position="175"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="70"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="27">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00077013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00078544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00078969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="461" mass="53051" checksum="D668CD0FE4A6B3E5" modified="2019-12-11" version="1">MAEVGEVIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHDRLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVKRKVEVVSPATPVPSETAPASVFPQNGSTRRALAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTALPVLYLCEFCLKYGKSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVH5</accession>
    <name>A0A5F8GVH5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Receptor-type tyrosine-protein phosphatase S</fullName>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Receptor-type tyrosine-protein phosphatase sigma</fullName>
        </alternativeName>
    </protein>
    <organism evidence="37 38">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="37" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="37" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Synapse</location>
            <location evidence="26">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="Ensembl" id="ENSMODT00000071434.1">
        <property type="protein sequence ID" value="ENSMODP00000051206.1"/>
        <property type="gene ID" value="ENSMODG00000045528.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153617"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000045528">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd05738">
        <property type="entry name" value="IgI_2_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05739">
        <property type="entry name" value="IgI_3_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000549">
        <property type="entry name" value="Protein tyrosine phosphatase, receptor type S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000027">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000036">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000066">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000068">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000144">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000015">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000082">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0966">Cell projection</keyword>
    <keyword evidence="25" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="22" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="24" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="19 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-0675">Receptor</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0770">Synapse</keyword>
    <keyword evidence="9" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="11 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 32" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="1241"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="35">
        <location>
            <begin position="8"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="35">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="35">
        <location>
            <begin position="233"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="322"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="417"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="515"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="609"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="699"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="799"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="897"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="997"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="33">
        <location>
            <begin position="1322"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="34">
        <location>
            <begin position="1326"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00073611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00079496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1393" mass="154099" checksum="B16956AB013A7EA4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVH6</accession>
    <name>A0A5F8GVH6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrosomal protein 112</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CEP112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVH6"/>
    <dbReference type="Ensembl" id="ENSMODT00000062876.1">
        <property type="protein sequence ID" value="ENSMODP00000051359.1"/>
        <property type="gene ID" value="ENSMODG00000023922.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006544"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023922">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055310">
        <property type="entry name" value="CEP112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18871">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 112 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18871:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 112 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="575" mass="69033" checksum="B3852513456D6871" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6G3</accession>
    <name>A0A5F8H6G3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ADAM metallopeptidase domain 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ADAM19</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6G3"/>
    <dbReference type="Ensembl" id="ENSMODT00000088243.1">
        <property type="protein sequence ID" value="ENSMODP00000054821.1"/>
        <property type="gene ID" value="ENSMODG00000008386.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159624"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008386">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF19">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00289">
        <property type="entry name" value="DISINTEGRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="13">
        <location>
            <begin position="128"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="12">
        <location>
            <begin position="334"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="670"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="837" mass="92560" checksum="434975934840A219" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6G4</accession>
    <name>A0A5F8H6G4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Disco interacting A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DIP2A</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000082750.1">
        <property type="protein sequence ID" value="ENSMODP00000055523.1"/>
        <property type="gene ID" value="ENSMODG00000008324.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182997"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008324">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000002">
        <property type="entry name" value="Disco interacting protein 2 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF34">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="227"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="807"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="908"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1359" mass="147023" checksum="CDE57DEE5FFCBD52" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6G5</accession>
    <name>A0A5F8H6G5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GYG1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:23361"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:56561"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="14"/>
    <dbReference type="Ensembl" id="ENSMODT00000054845.1">
        <property type="protein sequence ID" value="ENSMODP00000055149.1"/>
        <property type="gene ID" value="ENSMODG00000021257.4"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100012580"/>
    <dbReference type="GeneTree" id="ENSGT00940000154674"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021257">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000025">
        <property type="entry name" value="Glycogenin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="353" mass="40031" checksum="4C10B8BF4061E9E8" modified="2019-12-11" version="1">MTDQSFVTLSTNDSYAKGALVLGSSMKQHRTTKRLTVLITPQVSEPMRKVLEKIFDEVIMVDILDSKDSAHLTLMKRPELGVTLTKLHCWSLIQYQXXXXCVFMDADTLVLTNIDELFEREELSAAPDPGWPDCFNSGVFVYRPSIETYNQLLHMASEQGSFDGGDQGLLNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKAFGANAKVVHFLGRVKPWNYTYDPRTKSVRSDIHDPTVVNPQFLTMWWDIFSTSILPLLQQFGVVKDTFTTLNALSGLAYTLAFSCGFCRKEEVTDAISHMSIGNLSPPPQPFVSSDERKERWEQGQADYMGADSFDNIKRKLDTYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6G6</accession>
    <name>A0A5F8H6G6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger and SCAN domain containing 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ZSCAN16</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6G6"/>
    <dbReference type="Ensembl" id="ENSMODT00000057167.1">
        <property type="protein sequence ID" value="ENSMODP00000055575.1"/>
        <property type="gene ID" value="ENSMODG00000007492.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163165"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007492">
        <property type="expression patterns" value="Expressed in ovary and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050916">
        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF28">
        <property type="entry name" value="SCAN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="2">
        <location>
            <begin position="43"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="196" mass="23223" checksum="B9049E05229C6994" modified="2019-12-11" version="1">MATHLNSEALEEQEDLFIVKEEAHYWEQESSLQHNHSTSEVFRQHFRQLCYQETSGPREALTRLRELCHQWLRPEMHTKEQILEFLVLEQFLTILPKDLQTWVQDHHPENGEEAVTVLEDLEREIDEPAYQGPANVHRQETLFEEIAPKGTSRTSTESLSIHLNPRKTQLKWKSWELYPLQKNGNKQNSFVLGRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6G7</accession>
    <name>A0A5F8H6G7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM122A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PABIR3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM122 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007507282.1">
        <property type="nucleotide sequence ID" value="XM_007507220.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016282167.1">
        <property type="nucleotide sequence ID" value="XM_016426681.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056664813.1">
        <property type="nucleotide sequence ID" value="XM_056808835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6G7"/>
    <dbReference type="Ensembl" id="ENSMODT00000078041.1">
        <property type="protein sequence ID" value="ENSMODP00000055387.1"/>
        <property type="gene ID" value="ENSMODG00000015185.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100014136"/>
    <dbReference type="CTD" id="159091"/>
    <dbReference type="GeneTree" id="ENSGT00390000015476"/>
    <dbReference type="OrthoDB" id="10036177at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015185">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF3">
        <property type="entry name" value="PABIR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="244" mass="26710" checksum="22758B00EF74630A" modified="2019-12-11" version="1">MDPSDNSQIFQADMLRTRRNSTTFLNRHNLLPPSSPLRIPSSRIHQIKQEEGMDMLNRETVHEREIQTAMQISQTWEEILTLNDDGEKTSSPRRVDFIPVSPSPSPTRGIGKQCYSPSLQTFVASNGMPPSPIPSPTRRFATRRSQSPINCIRPSVLGPIKRKGDMENEDQPKRFFQGTSSSLLSPEAPSIPDMCLPSDALDGNGSSAGSSCNSPAKVSTTTDSPVSPSDSVSPFVPVDELSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6G8</accession>
    <name>A0A5F8H6G8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1 open reading frame, human C16orf95</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6G8"/>
    <dbReference type="Ensembl" id="ENSMODT00000080232.1">
        <property type="protein sequence ID" value="ENSMODP00000055528.1"/>
        <property type="gene ID" value="ENSMODG00000045409.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003910"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000045409">
        <property type="expression patterns" value="Expressed in spermatid and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027919">
        <property type="entry name" value="DUF4568"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14693">
        <property type="entry name" value="RIKEN CDNA 1700018B08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14693:SF0">
        <property type="entry name" value="RIKEN CDNA 1700018B08 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15132">
        <property type="entry name" value="DUF4568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="236" mass="27989" checksum="9D9CC3E652429A1D" modified="2019-12-11" version="1">MISMHPRRKEHRELNWNPEVNKSILRNKHLQDLKADVTFVDFKDPSCYGNLSHLVPECCHCYFRPHDFGGFLPVPRNEANFPYWVPRSLRSQKPVHRKVRFSVPENLKTCTCPCHSFGGHLPVPREFAPFPYWVPQSIRLLGKIKKNSASPMWTKGNFYVDNQLYYHYKHWRVCCDDIQLSKWQKIQAIIPQPITSWAIVEEEECVVPFVSPWVFFSCFYNLMTALISALRYLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6G9</accession>
    <name>A0A5F8H6G9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abhydrolase domain containing 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ABHD18</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6G9"/>
    <dbReference type="Ensembl" id="ENSMODT00000084324.1">
        <property type="protein sequence ID" value="ENSMODP00000054826.1"/>
        <property type="gene ID" value="ENSMODG00000012274.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014635"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012274">
        <property type="expression patterns" value="Expressed in spermatid and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="409" mass="46305" checksum="007E2D5C20BC3729" modified="2019-12-11" version="1">MGILSTIQRTPNPNTIQFDTISKEGVVSNSFHDTNMVLVPKFQFIVPKEWNNKYRPVCIHLAGTGDHHYWRRRTLMARPMIKEARMASLLLENPYYILLKPKDQVRSSLKNVSDLFVMGGALVLESAALLHWLEREGYGPLGMTGISMGGHMASLAVTNWPKPLPLIPCLSWSTASGVFTTGVLSKSVNWRELEKQYYTQTVYEEEIFHMLEYCGTDSFKMGQDFVKHFPNSVDNLTDFNLTPRTLNLDLDESFCMKSAQCHNSGKASVGSASEGLVFGDKIQALSKTLSAQSSGSESTTQQSNRPLREERRRRSLQKESLMFMKGVMDECTHVANFSVPVDPSLIIVVQAKEDAYIPRTGVRSLQEIWPGCEIRYLEGGHISAYLFKQGLFRQAIYDAFERFLHKYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6H1</accession>
    <name>A0A5F8H6H1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GNL2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6H1"/>
    <dbReference type="FunCoup" id="A0A5F8H6H1">
        <property type="interactions" value="1884"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055580"/>
    <dbReference type="Ensembl" id="ENSMODT00000072644.1">
        <property type="protein sequence ID" value="ENSMODP00000055580.1"/>
        <property type="gene ID" value="ENSMODG00000017773.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00810000125524"/>
    <dbReference type="InParanoid" id="A0A5F8H6H1"/>
    <dbReference type="OMA" id="KNPEDHI"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017773">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="207"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="604"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="726"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="777" mass="88699" checksum="CA2047A80E30480F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6H5</accession>
    <name>A0A5F8H6H5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Semaphorin 4D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SEMA4D</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6H5"/>
    <dbReference type="Ensembl" id="ENSMODT00000064968.1">
        <property type="protein sequence ID" value="ENSMODP00000055159.1"/>
        <property type="gene ID" value="ENSMODG00000013348.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159594"/>
    <dbReference type="OMA" id="PSRGWIQ"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013348">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000120">
        <property type="entry name" value="Semaphorin 4D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000013">
        <property type="entry name" value="Semaphorin 4D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF18">
        <property type="entry name" value="SEMAPHORIN-4D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023925791" evidence="8">
        <location>
            <begin position="24"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="9">
        <location>
            <begin position="19"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="670" mass="75058" checksum="1A1DBFDA19B4276B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6H6</accession>
    <name>A0A5F8H6H6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1 family domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SCFD1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6H6"/>
    <dbReference type="Ensembl" id="ENSMODT00000075471.1">
        <property type="protein sequence ID" value="ENSMODP00000055585.1"/>
        <property type="gene ID" value="ENSMODG00000017563.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074845"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017563">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="88" mass="9961" checksum="EEE3D6AB20C9D6BA" modified="2019-12-11" version="1">MLNFNVPHVKNNTGEPVWKVLIFDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRMCQESVVGVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6H7</accession>
    <name>A0A5F8H6H7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6H7"/>
    <dbReference type="Ensembl" id="ENSMODT00000080910.1">
        <property type="protein sequence ID" value="ENSMODP00000055538.1"/>
        <property type="gene ID" value="ENSMODG00000023663.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154650"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023663">
        <property type="expression patterns" value="Expressed in spermatocyte and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000040">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000020">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000914">
        <property type="entry name" value="Zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000551">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000204">
        <property type="entry name" value="Zinc finger protein 331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001532">
        <property type="entry name" value="Zinc finger protein 483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000427">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="723" mass="84467" checksum="EA52B4645002C4ED" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6H9</accession>
    <name>A0A5F8H6H9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARB2 cotranscriptional regulator A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ARB2A</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6H9"/>
    <dbReference type="FunCoup" id="A0A5F8H6H9">
        <property type="interactions" value="3587"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055397"/>
    <dbReference type="Ensembl" id="ENSMODT00000067025.1">
        <property type="protein sequence ID" value="ENSMODP00000055397.1"/>
        <property type="gene ID" value="ENSMODG00000020131.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063907"/>
    <dbReference type="InParanoid" id="A0A5F8H6H9"/>
    <dbReference type="OMA" id="LAFVELX"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020131">
        <property type="expression patterns" value="Expressed in spermatid and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014032">
        <property type="term" value="P:neural crest cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF3">
        <property type="entry name" value="COTRANSCRIPTIONAL REGULATOR FAM172A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023903709" evidence="2">
        <location>
            <begin position="21"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2" evidence="3">
        <location>
            <begin position="56"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="440" mass="50725" checksum="2E03DF4275346E56" modified="2019-12-11" version="1">MSISIISLIWLTLWINMAQLQQGGPDEKEKTTALKDLLSRIDLDELMKKDEPPLEFPDTLEGFEYAFNEKGQLRHITTGEPFVFNAREDLHRWNQKRYEALGEIITKYIYELLEKDCNLKKISLPVDATESEPKNFIFMSEDAMTNPDKLMVLIHGSGVVRAGQWARRLIINEDLDSGTQIPYIKRAMDEGYGVIVLNPNENYIEVEKTKSQVQLSSDGSDEPAEKRERKDKTFKEAKKRRDFYEKYRNPQKEKEMVPLYIRDNGSPEEHLIYVWDHFITHSAAENTFFVAHSYGGLAFVELTHLMEQTPVASLFAVSGCLTHFLEMIQREADVKNKVTAVALTDSVHNVWHQEAGKTIREWMRENCCNWVSSSEPLDTSVESMLPDCPRVSAGTERHELTSWKSLPSIFKFFTEASEAKNSSLKASLTRRSHRIKHEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6I2</accession>
    <name>A0A5F8H6I2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane-spanning 4-domains subfamily A member 4A-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MS4A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6I2"/>
    <dbReference type="FunCoup" id="A0A5F8H6I2">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055543"/>
    <dbReference type="Ensembl" id="ENSMODT00000069113.1">
        <property type="protein sequence ID" value="ENSMODP00000055543.1"/>
        <property type="gene ID" value="ENSMODG00000044115.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155376"/>
    <dbReference type="InParanoid" id="A0A5F8H6I2"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000044115">
        <property type="expression patterns" value="Expressed in spermatid and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF128">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="295" mass="32583" checksum="E2F3210F1D7FE62A" modified="2019-12-11" version="1">MLRASHFGGNMAEIFSLENQKMSPFKGLLRRQSMFRENDQGISSDLMESQDASKGVLPFCPQPGPESFPQGQIAIPVQSYQDQWKEPQQKFLKGDPKALGTVQIMIAFMNFSLGMLFVLLPEDINGRRHFLVYTGYVFWGTAFFIISGFLSIAAEKRATTIMVQSSLAMNVVSSVMAGLGIIFLSINFLTHIFLYDCREQGSHFSCIILKSIFLGINVILLILAILEFLVSIITSCFGCKGLGCDQSEVTILMPPSSYYLPENPAAEAYNRGTMPQHPVIDTATALPGSHPDDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6I3</accession>
    <name>A0A5F8H6I3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Solute carrier family 5 member 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6I3"/>
    <dbReference type="Ensembl" id="ENSMODT00000046940.2">
        <property type="protein sequence ID" value="ENSMODP00000054841.1"/>
        <property type="gene ID" value="ENSMODG00000031558.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155166"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000031558">
        <property type="expression patterns" value="Expressed in spermatocyte and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF10">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="68099" checksum="2287E44232772ADC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7F4</accession>
    <name>A0A5F8H7F4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Metalloendopeptidase</fullName>
            <ecNumber evidence="21">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">TLL2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="20 21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="20 21">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="21"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7F4"/>
    <dbReference type="Ensembl" id="ENSMODT00000070951.1">
        <property type="protein sequence ID" value="ENSMODP00000055474.1"/>
        <property type="gene ID" value="ENSMODG00000004648.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160572"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004648">
        <property type="expression patterns" value="Expressed in hindlimb bud and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04281">
        <property type="entry name" value="ZnMc_BMP1_TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000022">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000004">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000007">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000009">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000011">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000014">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000004">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015446">
        <property type="entry name" value="BMP_1/tolloid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034036">
        <property type="entry name" value="ZnMP_TLD/BMP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF45">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001199">
        <property type="entry name" value="BMP_1/tolloid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="15 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 20 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 18 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 20 21" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 20 21" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="11 18 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="24">
        <location>
            <begin position="87"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="22">
        <location>
            <begin position="289"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="22">
        <location>
            <begin position="402"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="514"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="22">
        <location>
            <begin position="558"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="22">
        <location>
            <begin position="714"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="22">
        <location>
            <begin position="827"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="active site" evidence="17 20">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001199-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="953" mass="108036" checksum="FB5859C04F806C6A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7G1</accession>
    <name>A0A5F8H7G1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Early endosome antigen 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">EEA1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="FunCoup" id="A0A5F8H7G1">
        <property type="interactions" value="1403"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055920"/>
    <dbReference type="Ensembl" id="ENSMODT00000082944.1">
        <property type="protein sequence ID" value="ENSMODP00000055920.1"/>
        <property type="gene ID" value="ENSMODG00000009488.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156910"/>
    <dbReference type="InParanoid" id="A0A5F8H7G1"/>
    <dbReference type="OMA" id="FIAVYQH"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009488">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030742">
        <property type="term" value="F:GTP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044788">
        <property type="term" value="P:host-mediated perturbation of viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15730">
        <property type="entry name" value="FYVE_EEA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.390:FF:000006">
        <property type="entry name" value="Early endosome antigen 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000180">
        <property type="entry name" value="Early endosome antigen 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="17">
        <location>
            <begin position="1391"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="138"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="276"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="972"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1450" mass="167167" checksum="F587C6950E97099F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7G5</accession>
    <name>A0A5F8H7G5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Solute carrier family 16 member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SLC16A4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7G5"/>
    <dbReference type="Ensembl" id="ENSMODT00000079009.1">
        <property type="protein sequence ID" value="ENSMODP00000055484.1"/>
        <property type="gene ID" value="ENSMODG00000001701.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158411"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001701">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000277">
        <property type="entry name" value="Solute carrier family 16 member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000141">
        <property type="entry name" value="Solute carrier family 16, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF14">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="495" mass="54573" checksum="7FB729D4E2EA9789" modified="2019-12-11" version="1">MGMDDSVSFLPAQPKSKQATMYLRSKKVQSRFSMVNVLLMGLTKNFAIFFVVFQEEFGGTSEQIGWIGSLMSSLRFIAAPLAAILCEKVGEKFTSILGALLISTGYLISSLATSISFLCLSLGLLPGLGSALLYIGGPLMIAKYFKKRLALSIAIARSGMGLTFVLAPLTKILIDEYDWPGTLLIFGAISLNLVPSSMLLRPINNKRKEHLSTKGEGRLTMRRPDAVSQLEALSSNDGQQPPTENCLVSKDEQTGQSAAISGCPDDKEVFSNEPQRYDKNAVPGIHKQLVDFSLFKNPLFYLFTWCFLFGQLAYFIPTFHLVARAKTLGIDTLDASYFISVAGITETVMQPLSGWAADQNWIKRYNFYKSYLILCGITNLLCPLATTFPLLMTYSIFFGIFCGCYMAVVFPVMVDFAGNCPLNRFLGFSAFFAGLAVLAGPPIAGWLYDYTQTYIYSFFFSGACFLLSSASLFFVPLAMKWVKGRASQEMTTPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7G6</accession>
    <name>A0A5F8H7G6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1</fullName>
            <ecNumber evidence="10">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">TAR RNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TARBP1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:20078"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="10"/>
    <dbReference type="Ensembl" id="ENSMODT00000081954.1">
        <property type="protein sequence ID" value="ENSMODP00000055742.1"/>
        <property type="gene ID" value="ENSMODG00000008504.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003939"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008504">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141100">
        <property type="term" value="F:tRNA (guanine(18)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000010">
        <property type="entry name" value="probable methyltransferase TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025806">
        <property type="entry name" value="TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056921">
        <property type="entry name" value="TARBP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25050">
        <property type="entry name" value="TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51624">
        <property type="entry name" value="SAM_MT_TRMH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TARBP1" evidence="14">
        <location>
            <begin position="303"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="13">
        <location>
            <begin position="1464"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1620" mass="183243" checksum="539E117B6D613D49" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7G7</accession>
    <name>A0A5F8H7G7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Tenascin C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TNC</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tenascin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000067007.1">
        <property type="protein sequence ID" value="ENSMODP00000055925.1"/>
        <property type="gene ID" value="ENSMODG00000019592.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155188"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019592">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000099">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000001">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000162">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000201">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000207">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000274">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000293">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000398">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000529">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000611">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041161">
        <property type="entry name" value="EGF_Tenascin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF1">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18720">
        <property type="entry name" value="EGF_Tenascin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023878228" evidence="13">
        <location>
            <begin position="23"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="624"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="804"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="896"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="986"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1077"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1168"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1252"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1434"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1524"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1614"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1701"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="16">
        <location>
            <begin position="1787"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2013" mass="221058" checksum="6B762253134C3A4F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7H0</accession>
    <name>A0A5F8H7H0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Otogelin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OTOG</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the otogelin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000072640.1">
        <property type="protein sequence ID" value="ENSMODP00000055176.1"/>
        <property type="gene ID" value="ENSMODG00000006791.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157490"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006791">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23400">
        <property type="entry name" value="beta-trefoil_ABD_OTOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000397">
        <property type="entry name" value="Otogelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058755">
        <property type="entry name" value="Fn1-VW_OTOGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058754">
        <property type="entry name" value="OTOGL-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058753">
        <property type="entry name" value="TIL_OTOGL_Mucin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF228">
        <property type="entry name" value="OTOGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25960">
        <property type="entry name" value="Fn1-VW_OTOGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25961">
        <property type="entry name" value="OTOGL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25962">
        <property type="entry name" value="TIL_OTOGL_Mucin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="64"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="426"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="892"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="1973"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="10">
        <location>
            <begin position="2688"/>
            <end position="2773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1385"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1428"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1557"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1601"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1430"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1601"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="2702"/>
            <end position="2751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2773" mass="302399" checksum="57F5125C54C2C128" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7H1</accession>
    <name>A0A5F8H7H1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kelch-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KLHL3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Component of the BCR(KLHL3) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL3 and RBX1. Interacts with CLDN8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KLHL3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7H1"/>
    <dbReference type="Ensembl" id="ENSMODT00000054177.1">
        <property type="protein sequence ID" value="ENSMODP00000055747.1"/>
        <property type="gene ID" value="ENSMODG00000014989.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157891"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014989">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18513">
        <property type="entry name" value="BACK_KLHL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18339">
        <property type="entry name" value="BTB_POZ_KLHL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000002">
        <property type="entry name" value="Kelch-like family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030578">
        <property type="entry name" value="KLHL3_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF179">
        <property type="entry name" value="KELCH-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="50"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="588" mass="65282" checksum="EBE488957013CC0E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7H4</accession>
    <name>A0A5F8H7H4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SEL1L family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SEL1L3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7H4"/>
    <dbReference type="Ensembl" id="ENSMODT00000077763.1">
        <property type="protein sequence ID" value="ENSMODP00000055930.1"/>
        <property type="gene ID" value="ENSMODG00000000154.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159983"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000154">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000171">
        <property type="entry name" value="protein sel-1 homolog 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042756">
        <property type="entry name" value="Sel-1L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44444">
        <property type="entry name" value="PROTEIN SEL-1 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44444:SF1">
        <property type="entry name" value="PROTEIN SEL-1 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1112" mass="126981" checksum="5198B17184FA0094" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7H6</accession>
    <name>A0A5F8H7H6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">SH3 domain-containing kinase-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">SH3KBP1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Synapse</location>
            <location evidence="19">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7H6"/>
    <dbReference type="FunCoup" id="A0A5F8H7H6">
        <property type="interactions" value="1131"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055752"/>
    <dbReference type="Ensembl" id="ENSMODT00000070253.1">
        <property type="protein sequence ID" value="ENSMODP00000055752.1"/>
        <property type="gene ID" value="ENSMODG00000008531.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155886"/>
    <dbReference type="InParanoid" id="A0A5F8H7H6"/>
    <dbReference type="OMA" id="PNSCHRS"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008531">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12052">
        <property type="entry name" value="SH3_CIN85_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12055">
        <property type="entry name" value="SH3_CIN85_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12057">
        <property type="entry name" value="SH3_CIN85_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000089">
        <property type="entry name" value="SH3 domain-containing kinase-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000094">
        <property type="entry name" value="SH3 domain-containing kinase-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000112">
        <property type="entry name" value="SH3 domain-containing kinase-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035770">
        <property type="entry name" value="CIN85_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035771">
        <property type="entry name" value="CIN85_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035772">
        <property type="entry name" value="CIN85_SH3_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF6">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="15 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 21" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="14" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="8" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SH3" evidence="24">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="24">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="24">
        <location>
            <begin position="311"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="372"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="655"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="399"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="605"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00074272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="706" mass="78310" checksum="7DC1765ABE66E7D0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7H7</accession>
    <name>A0A5F8H7H7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphodiesterase</fullName>
            <ecNumber evidence="10">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PDE7B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7H7"/>
    <dbReference type="Ensembl" id="ENSMODT00000068654.1">
        <property type="protein sequence ID" value="ENSMODP00000055181.1"/>
        <property type="gene ID" value="ENSMODG00000017463.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159413"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017463">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000004">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="12">
        <location>
            <begin position="92"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="408"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="168"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="450" mass="51818" checksum="844DC8C7AC7F6D1B" modified="2019-12-11" version="1">MKRCGEISFDNPDQNAKCVCMLGDVRVRGQTGVPAERRGSYPFIDFRLLNNTAHSGEIGTKKKVKRLLSFQRYFHVSRLHRGAIPQAPLHFLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNTLVPLLCHLFNIHGLIHHFQLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMNCFLKEPKLSSFLTPLDIMLGLLSAVTHDLDHPGVNQLFLIKTNHHLCSLYQNISVLENHHWRSAVCLLRESRLFAHLPKEMTQDIEQRLGSLILATDITRQKEFLTRLENHLKNQDLRLEDAQNRHFILQIALKCADICNPCRIWEVSKQWSERVCEEFYRQGDLEQKFKLEISPLCNQQEDSIPSIQIGFMTHIAEPLFKKWYHFTESPLGENMLSHLTTNKAKWKSIQHTQHSSNGGSSGSNSNKINDHAGQGTENEEQTVNEGDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7H8</accession>
    <name>A0A5F8H7H8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Deubiquitinase DESI2</fullName>
            <ecNumber evidence="4">3.1.2.22</ecNumber>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Desumoylating isopeptidase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">PPPDE peptidase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Palmitoyl protein thioesterase DESI2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Protein FAM152A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">S-depalmitoylase DESI2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">DESI2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with RPS7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="4"/>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7H8"/>
    <dbReference type="FunCoup" id="A0A5F8H7H8">
        <property type="interactions" value="1349"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055494"/>
    <dbReference type="Ensembl" id="ENSMODT00000056080.1">
        <property type="protein sequence ID" value="ENSMODP00000055494.1"/>
        <property type="gene ID" value="ENSMODG00000006533.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111005"/>
    <dbReference type="InParanoid" id="A0A5F8H7H8"/>
    <dbReference type="OMA" id="PLEGCRW"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006533">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF6">
        <property type="entry name" value="DEUBIQUITINASE DESI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="PPPDE" evidence="20">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="213" mass="23774" checksum="72B894526CAA52FD" modified="2019-12-11" version="1">MGANQLVVLNVYDMYWMNEYTSSIGIGVFHSGIEVYGRVVVTDKNPFRRSLKRKEGTEFAYGGHPYPFSGIFEISPGNASELGETFKFKEAVVLGSTDFLENDLEKIVEELGKEYRGNAYHLMHKNCNHFSSALSEILCGKEIPRWVNRLAYFSSCIPFLQSCLPKEWLTPAALQSSVSQELQDELEEAEDAAAAAVMSSASAMSRPGRHTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>F6RCG9</accession>
    <name>F6RCG9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TUBA4A</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6RCG9"/>
    <dbReference type="Ensembl" id="ENSMODT00000037686.2">
        <property type="protein sequence ID" value="ENSMODP00000036097.2"/>
        <property type="gene ID" value="ENSMODG00000018851.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183165"/>
    <dbReference type="HOGENOM" id="CLU_1726419_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018851">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6RCG9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="56"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="255"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000036097.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="455" mass="51028" checksum="AB36BD0BCDD0F9E2" modified="2019-12-11" version="2">MRLAPPQSYKSCAALQLAQFSPRSVTQTLRETFRPGPPPCVNASQSTSDRRVSRWAMPVGNYTAWNMHVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLDRIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVSEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGIDSYEDEDEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F6SFJ9</accession>
    <name>F6SFJ9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane integral NOTCH2 associated receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MINAR1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MINAR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6SFJ9"/>
    <dbReference type="Ensembl" id="ENSMODT00000024672.3">
        <property type="protein sequence ID" value="ENSMODP00000024243.3"/>
        <property type="gene ID" value="ENSMODG00000019431.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSCS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063851"/>
    <dbReference type="HOGENOM" id="CLU_016692_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019431">
        <property type="expression patterns" value="Expressed in spinal cord and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039706">
        <property type="entry name" value="MINAR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009626">
        <property type="entry name" value="MINAR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055117">
        <property type="entry name" value="MINAR1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31530:SF2">
        <property type="entry name" value="MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31530">
        <property type="entry name" value="MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1 MINAR1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06789">
        <property type="entry name" value="MINAR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22948">
        <property type="entry name" value="MINAR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MINAR1 N-terminal helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Major intrinsically disordered Notch2-binding receptor 1-like C-terminal" evidence="7">
        <location>
            <begin position="759"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="652"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="747"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="747"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000024243.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="854" mass="96519" checksum="B124E4D8E3FB3489" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F6ULN0</accession>
    <name>F6ULN0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 7 member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLC7A4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6ULN0"/>
    <dbReference type="Ensembl" id="ENSMODT00000018252.3">
        <property type="protein sequence ID" value="ENSMODP00000017922.3"/>
        <property type="gene ID" value="ENSMODG00000014340.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154637"/>
    <dbReference type="HOGENOM" id="CLU_007946_15_7_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014340">
        <property type="expression patterns" value="Expressed in cerebellum and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF4">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="9">
        <location>
            <begin position="564"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000017922.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="665" mass="70887" checksum="383BFB952E5EE86A" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F6WRA2</accession>
    <name>F6WRA2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Butyrophilin-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC107650783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. BTN/MOG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6WRA2"/>
    <dbReference type="Ensembl" id="ENSMODT00000033072.3">
        <property type="protein sequence ID" value="ENSMODP00000031499.3"/>
        <property type="gene ID" value="ENSMODG00000010314.4"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100028244"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271914"/>
    <dbReference type="HOGENOM" id="CLU_013137_22_0_1"/>
    <dbReference type="OMA" id="FIMMAIF"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010314">
        <property type="expression patterns" value="Expressed in liver and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6WRA2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05713">
        <property type="entry name" value="IgV_MOG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13733">
        <property type="entry name" value="SPRY_PRY_C-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000073">
        <property type="entry name" value="Butyrophilin like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000088">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000208">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF153">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="168"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="9">
        <location>
            <begin position="295"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000031499.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="509" mass="58655" checksum="CBE5BAB4CEC113B2" modified="2019-12-11" version="3">MNLLLVFMNRFKDMFNISTLSFFQVSKTFKHHLLLMFVVSLIDLGSGHFQVIGPDKPIQTLVGEDILFSCHVSPMLNLENMEVRFFRNQFSSLLVLYKDGKETKERQMQEYQGRTQFVQDAIPEGRVSLKLKNIILSDAGIYGCRFSSQTFYQEYTWELQVAALGSTPLISLEKYITSGILLKCQSTGWFPKPTVQWKNHQGKHLSSDFKANTRDDGLFDIETSLTIQESSIGDISCSIHTWELRKESRVRIADPFLQPSPWIYGFSIMLAIVLIVAVYGVFLHIRKVKLEKNLEWRRKMGEKGWRYATKHAVEVTLDQETANPLLQISEDCKTVSYNDTSMVVSMPENEKIFHSPCVVASQGFYMGECYWEVEVGKKNRWYLGVCLDSVNRKEKLPKLNPANGYWVLGRWNQYEHFVFSPNRQILTLQVHPMKIGIFLNYKYGQISFFNVTNKSHIYTFTGCNFNGKILHPYFRPRSNDIQEPSYPLTICTKFPGTAGNDTSPSNNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>F6XUX9</accession>
    <name>F6XUX9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dual specificity protein kinase TTK</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TTK</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates. Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with TPR; the interactions occurs in a microtubule-independent manner. Interacts with MAD1L1 and MAD2L1.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_056674498.1">
        <property type="nucleotide sequence ID" value="XM_056818520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6XUX9"/>
    <dbReference type="Ensembl" id="ENSMODT00000023373.4">
        <property type="protein sequence ID" value="ENSMODP00000022965.4"/>
        <property type="gene ID" value="ENSMODG00000018418.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100023737"/>
    <dbReference type="CTD" id="7272"/>
    <dbReference type="eggNOG" id="KOG0596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182984"/>
    <dbReference type="HOGENOM" id="CLU_010380_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018418">
        <property type="expression patterns" value="Expressed in hindlimb bud and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000308">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000101">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="531"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="363"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000022965.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="866" mass="98027" checksum="9F6033B5C42A5F21" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>F6Y6D4</accession>
    <name>F6Y6D4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myotubularin related protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6Y6D4"/>
    <dbReference type="Ensembl" id="ENSMODT00000031057.3">
        <property type="protein sequence ID" value="ENSMODP00000029482.2"/>
        <property type="gene ID" value="ENSMODG00000009082.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157272"/>
    <dbReference type="HOGENOM" id="CLU_001839_2_2_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009082">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6Y6D4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13341">
        <property type="entry name" value="PH-GRAM_MTMR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14586">
        <property type="entry name" value="PTP-MTMR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035888">
        <property type="entry name" value="MTMR3_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046352">
        <property type="entry name" value="MTMR3_PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF66">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="7">
        <location>
            <begin position="155"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="979"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="3">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="351"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="413"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000029482.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1135" mass="126333" checksum="4196C374A1A323CC" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F7AKX6</accession>
    <name>F7AKX6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2 open reading frame, human C17orf80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MTNAP1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F7AKX6"/>
    <dbReference type="Ensembl" id="ENSMODT00000008337.4">
        <property type="protein sequence ID" value="ENSMODP00000008172.4"/>
        <property type="gene ID" value="ENSMODG00000006589.4"/>
    </dbReference>
    <dbReference type="GeneID" id="103094597"/>
    <dbReference type="CTD" id="55028"/>
    <dbReference type="eggNOG" id="KOG4092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167290"/>
    <dbReference type="HOGENOM" id="CLU_037702_0_0_1"/>
    <dbReference type="OrthoDB" id="8921675at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006589">
        <property type="expression patterns" value="Expressed in spermatocyte and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037694">
        <property type="entry name" value="MTNAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16270">
        <property type="entry name" value="HYPOTHETICAL LOC287798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16270:SF5">
        <property type="entry name" value="HYPOTHETICAL LOC287798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000008172.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="573" mass="65555" checksum="9B6B154B080D6083" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F7AL94</accession>
    <name>F7AL94_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">EBF transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EBF2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7AL94"/>
    <dbReference type="Ensembl" id="ENSMODT00000010400.3">
        <property type="protein sequence ID" value="ENSMODP00000010203.3"/>
        <property type="gene ID" value="ENSMODG00000016702.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182859"/>
    <dbReference type="HOGENOM" id="CLU_016320_3_1_1"/>
    <dbReference type="OMA" id="QGYMRNS"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016702">
        <property type="expression patterns" value="Expressed in spinal cord and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4280:FF:000001">
        <property type="entry name" value="transcription factor COE1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032201">
        <property type="entry name" value="COE_HLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003523">
        <property type="entry name" value="Transcription_factor_COE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10747">
        <property type="entry name" value="TRANSCRIPTION FACTOR COE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16423">
        <property type="entry name" value="COE1_HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="IPT/TIG" evidence="12">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor COE helix-loop-helix" evidence="13">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000010203.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="240" mass="25847" checksum="94D5CECC93D5CF12" modified="2019-12-11" version="2">MVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLAKEMLLKRAADLVEALYGTPHNNQDIILKRAADIAEALYSVPRNPSQIPALSSSPAHSGMMGINSYGSQLGVSISESTQGNNQGYIRNTSSISPRGYSSSSTPQQSNYSTSSNSMNGYSNVPMANLGVPGSPGFLNGSPTGSPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>F7C0P2</accession>
    <name>F7C0P2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Histone-lysine N-methyltransferase NSD3</fullName>
            <ecNumber evidence="24">2.1.1.370</ecNumber>
            <ecNumber evidence="25">2.1.1.371</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Nuclear SET domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">NSD3</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64452"/>
            <dbReference type="Rhea" id="RHEA-COMP:15539"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.371"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64448"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.370"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="23">Interacts with BRD4. Interacts (via KIKL motif) with BRD3 (via NET domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.370" evidence="24"/>
    <dbReference type="EC" id="2.1.1.371" evidence="25"/>
    <dbReference type="Ensembl" id="ENSMODT00000013640.3">
        <property type="protein sequence ID" value="ENSMODP00000013395.3"/>
        <property type="gene ID" value="ENSMODG00000010691.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155355"/>
    <dbReference type="HOGENOM" id="CLU_004494_2_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010691">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140952">
        <property type="term" value="F:histone H3K27 dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140946">
        <property type="term" value="F:histone H3K4 dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15649">
        <property type="entry name" value="PHD1_NSD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15652">
        <property type="entry name" value="PHD2_NSD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15658">
        <property type="entry name" value="PHD4_NSD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15661">
        <property type="entry name" value="PHD5_NSD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20163">
        <property type="entry name" value="PWWP_NSD3_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20166">
        <property type="entry name" value="PWWP_NSD3_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19212">
        <property type="entry name" value="SET_NSD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000004">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000030">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000025">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000106">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000205">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000397">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041306">
        <property type="entry name" value="C5HCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055198">
        <property type="entry name" value="NSD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047456">
        <property type="entry name" value="PHD2_NSD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047458">
        <property type="entry name" value="PHD4_NSD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047527">
        <property type="entry name" value="PHD5_NSD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047451">
        <property type="entry name" value="PWWP_NSD3_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047453">
        <property type="entry name" value="PWWP_NSD3_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047461">
        <property type="entry name" value="SET_NSD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17982">
        <property type="entry name" value="C5HCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23011">
        <property type="entry name" value="PHD-1st_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22908">
        <property type="entry name" value="PHD_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17 29" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 28" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="33">
        <location>
            <begin position="261"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="31">
        <location>
            <begin position="692"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="33">
        <location>
            <begin position="951"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="AWS" evidence="35">
        <location>
            <begin position="1084"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="32">
        <location>
            <begin position="1136"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="34">
        <location>
            <begin position="1260"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="31">
        <location>
            <begin position="1312"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="88"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="177"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="397"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="537"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="29">
        <location>
            <begin position="1025"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="29">
        <location>
            <begin position="1286"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="30">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="30">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="30">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00056539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00065976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00066818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00066819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00068930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00081740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000013395.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1428" mass="160893" checksum="98CBFAD59D2AEEE3" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>F7CS58</accession>
    <name>F7CS58_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Zinc finger protein 423</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ZNF423</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="FunCoup" id="F7CS58">
        <property type="interactions" value="1711"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000016247"/>
    <dbReference type="Ensembl" id="ENSMODT00000016547.4">
        <property type="protein sequence ID" value="ENSMODP00000016247.4"/>
        <property type="gene ID" value="ENSMODG00000012988.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158492"/>
    <dbReference type="HOGENOM" id="CLU_004018_0_0_1"/>
    <dbReference type="InParanoid" id="F7CS58"/>
    <dbReference type="OMA" id="RDEGQGW"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012988">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050873">
        <property type="term" value="P:brown fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021930">
        <property type="term" value="P:cerebellar granule cell precursor proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120163">
        <property type="term" value="P:negative regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030513">
        <property type="term" value="P:positive regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021936">
        <property type="term" value="P:regulation of cerebellar granule cell precursor proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050872">
        <property type="term" value="P:white fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000468">
        <property type="entry name" value="B-cell lymphoma 6 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000244">
        <property type="entry name" value="zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000483">
        <property type="entry name" value="Zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000548">
        <property type="entry name" value="Zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000760">
        <property type="entry name" value="Zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001417">
        <property type="entry name" value="zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002384">
        <property type="entry name" value="zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004063">
        <property type="entry name" value="Zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000143">
        <property type="entry name" value="Zinc finger protein 521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000167">
        <property type="entry name" value="Zinc finger protein 521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000261">
        <property type="entry name" value="Zinc finger protein 521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF128">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="741"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="771"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="906"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="950"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="979"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="1140"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="1188"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="1218"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="1249"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="1279"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="363"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1156"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1168"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000016247.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1304" mass="147455" checksum="9B4845C1911CFC02" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F7D3S8</accession>
    <name>F7D3S8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7D3S8"/>
    <dbReference type="Ensembl" id="ENSMODT00000021051.3">
        <property type="protein sequence ID" value="ENSMODP00000020684.3"/>
        <property type="gene ID" value="ENSMODG00000016488.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000141094"/>
    <dbReference type="HOGENOM" id="CLU_001042_4_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016488">
        <property type="expression patterns" value="Expressed in hindlimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="18">
        <location>
            <begin position="577"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="291"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="733"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="856"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000020684.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1223" mass="139484" checksum="665D46CFA5288197" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>F7E6X1</accession>
    <name>F7E6X1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear factor of activated T cells 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NFATC3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7E6X1"/>
    <dbReference type="Ensembl" id="ENSMODT00000006643.3">
        <property type="protein sequence ID" value="ENSMODP00000006508.3"/>
        <property type="gene ID" value="ENSMODG00000005276.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156131"/>
    <dbReference type="HOGENOM" id="CLU_010185_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005276">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01178">
        <property type="entry name" value="IPT_NFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07881">
        <property type="entry name" value="RHD-n_NFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000040">
        <property type="entry name" value="Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000001">
        <property type="entry name" value="Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008366">
        <property type="entry name" value="NFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533">
        <property type="entry name" value="NFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533:SF6">
        <property type="entry name" value="NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01789">
        <property type="entry name" value="NUCFACTORATC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHD" evidence="11">
        <location>
            <begin position="388"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="680"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="836"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="875"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="932"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="949"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000006508.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1053" mass="114123" checksum="A6F401275E31AB92" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4A0</accession>
    <name>A0A5F8G4A0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 6 open reading frame, human C3orf14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CEP15</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4A0"/>
    <dbReference type="FunCoup" id="A0A5F8G4A0">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042264"/>
    <dbReference type="Ensembl" id="ENSMODT00000065973.1">
        <property type="protein sequence ID" value="ENSMODP00000042264.1"/>
        <property type="gene ID" value="ENSMODG00000025512.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005214"/>
    <dbReference type="InParanoid" id="A0A5F8G4A0"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025512">
        <property type="expression patterns" value="Expressed in testis and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028006">
        <property type="entry name" value="CEP15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14286:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN 15 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14286">
        <property type="entry name" value="GENE, 49355-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15134">
        <property type="entry name" value="CEP15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="201" mass="22778" checksum="0A093B4211C0E2AC" modified="2019-12-11" version="1">ASQSPADIRERTQILLRARSSCTDVQRRRRGLRRDATAHCVRRRRPGGGIAHPRREAKTIRPAWGHAQVFREDLGLGRAASGGGPKRGPPRLAQRLLLLQEMENDHGNQKTGKKTSHVKAAKLAQKRNRSLLQDIRTLEKRFEKEAHSRPPPELTNLQILYWALVEKQAPKWEQALLGRARRPAGARSWNQAGNDLQETPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4A1</accession>
    <name>A0A5F8G4A1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription initiation factor TFIID subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TAF1 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000085177.1">
        <property type="protein sequence ID" value="ENSMODP00000042288.1"/>
        <property type="gene ID" value="ENSMODG00000004570.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155242"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004570">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05511">
        <property type="entry name" value="Bromo_TFIID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1100.10">
        <property type="entry name" value="TAFII-230 TBP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011177">
        <property type="entry name" value="TAF1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009067">
        <property type="entry name" value="TAF_II_230-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036741">
        <property type="entry name" value="TAFII-230_TBP-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09247">
        <property type="entry name" value="TBP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003047">
        <property type="entry name" value="TAF1_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47055">
        <property type="entry name" value="TAF(II)230 TBP-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="1386"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="1509"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="111"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="959"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1097"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1126"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1222"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1618"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1463"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1108"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1222"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1627"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1640"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1670"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1680"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1709"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1733"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1812"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1353"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR003047-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR003047-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1860" mass="211005" checksum="FFEFE859F534044A" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4A3</accession>
    <name>A0A5F8G4A3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100618066</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4A3"/>
    <dbReference type="Ensembl" id="ENSMODT00000082530.1">
        <property type="protein sequence ID" value="ENSMODP00000042293.1"/>
        <property type="gene ID" value="ENSMODG00000048294.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155965"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000048294">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002888">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001530">
        <property type="entry name" value="Zinc finger protein 268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002102">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002004">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000292">
        <property type="entry name" value="zinc finger protein 619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001697">
        <property type="entry name" value="zinc finger protein 623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF317">
        <property type="entry name" value="ZINC FINGER PROTEIN 329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="662" mass="76273" checksum="3588FEFE9AF0D54C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4A4</accession>
    <name>A0A5F8G4A4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 345-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC103094147</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007490177.1">
        <property type="nucleotide sequence ID" value="XM_007490115.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4A4"/>
    <dbReference type="Ensembl" id="ENSMODT00000085950.1">
        <property type="protein sequence ID" value="ENSMODP00000042275.1"/>
        <property type="gene ID" value="ENSMODG00000023665.3"/>
    </dbReference>
    <dbReference type="GeneID" id="103094147"/>
    <dbReference type="GeneTree" id="ENSGT00940000161437"/>
    <dbReference type="OrthoDB" id="6591996at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023665">
        <property type="expression patterns" value="Expressed in forelimb bud and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004137">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000040">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000020">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001402">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF75">
        <property type="entry name" value="ZFP14 ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="648" mass="74481" checksum="FDCA75A70590D0DB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4A5</accession>
    <name>A0A5F8G4A5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4A5"/>
    <dbReference type="Ensembl" id="ENSMODT00000065491.1">
        <property type="protein sequence ID" value="ENSMODP00000042269.1"/>
        <property type="gene ID" value="ENSMODG00000000356.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000169329"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000356">
        <property type="expression patterns" value="Expressed in spermatocyte and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052859">
        <property type="entry name" value="LRR-IQ_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46723">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46723:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="430" mass="51462" checksum="752ECA45B18E858C" modified="2019-12-11" version="1">MEESREEHVNTLVQGRPGQPPRKESYARWLRGRKPFKFFKRKPLKIPTTPKKLSKGEKEKEQVPKEEHLPVKELVKEKPAVPEKQVHAFYKRMGSPIKHRILSAKHRSLLFHALSELRKKEYPQQLPRFKPIKVSKIPAEEKIDYQEMDFSFSMPVMKARMHLTSPSLLLPKLKEIKPETYHRPTFRLCHLVEKPEVQIIPYLERVEKKKPARPLCTVDFGPLLSVDRQYLKKEQKRNQQEKIALIAMIHLTDEITNQSVRDYIQERILSVKKRNEEESKKINEHLENFQANKTRVMKEFHERKTKFLEERQQRTEDRMLVEEICNQHCTLTKELFQFDRFKKRQDVMNDKKEFVNKMRETEKYRKTLVKRMKKGRWELREVMISLVFSFIIYRLKGLNMITSKEDISTSCSTITPSFQLKPRVLMKGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4A7</accession>
    <name>A0A5F8G4A7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BOLA class I histocompatibility antigen, alpha chain BL3-7-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the presentation of foreign antigens to the immune system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the MHC class I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4A7"/>
    <dbReference type="Ensembl" id="ENSMODT00000072831.1">
        <property type="protein sequence ID" value="ENSMODP00000042281.1"/>
        <property type="gene ID" value="ENSMODG00000043369.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271826"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000043369">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002474">
        <property type="term" value="P:antigen processing and presentation of peptide antigen via MHC class I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07698">
        <property type="entry name" value="IgC1_MHC_I_alpha3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000014">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000001">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF251">
        <property type="entry name" value="HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0490">MHC I</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="289"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="426" mass="47808" checksum="0CA3D5F4721923F2" modified="2019-12-11" version="1">MSNRLMKVSAAGDFLWVGFGFALLTCVCSFCPSTDDVFGVPFAIGLQSPSAANQKLRIRPYINQGTLFQGSFGFLCPGTMKPSLLSLFVLGVVALTETRAGSHSMRYFHTAMSRPELGDSQFITVGYVDDQQFVRFDSSSESQRMEPRAAWMDKMDEEEPNYWEEQTQIYRKNAQIYRRNLETLRGYYNQSQGGLHTIQRMYGCEVHPDGSFRKGFYQLAYDGRDYIALHRETLTWTAADPGAENTKRKWEAERSIAERYKAYLEETCLQWLKKYLQMGKDVLLRTDPPSARVSRHSGPDGEVSLRCRAQGFYPAEISLTWLRDGEEQLQDTEFIETRPGGDGTFQKWAAVAMAPGQEDRYSCRVQHEALAQPLSLRWEPEASSLWVIVGVTAGVLALVTAVVAGAVILRRRNSGGKGGAYVPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4A9</accession>
    <name>A0A5F8G4A9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYC associated factor X</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MAX</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4A9"/>
    <dbReference type="Ensembl" id="ENSMODT00000055339.1">
        <property type="protein sequence ID" value="ENSMODP00000042298.1"/>
        <property type="gene ID" value="ENSMODG00000043844.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064011"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000043844">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="96" mass="10522" checksum="4E7007CE84112219" modified="2019-12-11" version="1">MLYSNKGKARADQVLCSWGIHFSSSLMEDASKRKFRALEKARSSAQLQTNYSSSDSSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4B1</accession>
    <name>A0A5F8G4B1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase MRCK alpha</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">CDC42-binding protein kinase alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">CDC42BPA</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="Ensembl" id="ENSMODT00000052751.1">
        <property type="protein sequence ID" value="ENSMODP00000042280.1"/>
        <property type="gene ID" value="ENSMODG00000006246.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234517"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006246">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20864">
        <property type="entry name" value="C1_MRCKalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01243">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000014">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000010">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000032">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001055">
        <property type="entry name" value="Serine/threonine-protein kinase MRCK beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031597">
        <property type="entry name" value="KELK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014930">
        <property type="entry name" value="Myotonic_dystrophy_kinase_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF31">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MRCK ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08826">
        <property type="entry name" value="DMPK_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15796">
        <property type="entry name" value="KELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="16 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="77"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="30">
        <location>
            <begin position="344"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="27">
        <location>
            <begin position="971"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="25">
        <location>
            <begin position="1041"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="29">
        <location>
            <begin position="1186"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="28">
        <location>
            <begin position="1530"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1564"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="441"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="701"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="886"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1564"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1584"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1619"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1641"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1655"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1691" mass="192719" checksum="1A9000C17BB0CC3C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4B2</accession>
    <name>A0A5F8G4B2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Groucho/TLE N-terminal Q-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4B2"/>
    <dbReference type="Ensembl" id="ENSMODT00000067150.1">
        <property type="protein sequence ID" value="ENSMODP00000042292.1"/>
        <property type="gene ID" value="ENSMODG00000044776.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234519"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000044776">
        <property type="expression patterns" value="Expressed in heart and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005617">
        <property type="entry name" value="Groucho/TLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF33">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03920">
        <property type="entry name" value="TLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="6">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="146" mass="15727" checksum="431678B38EF31013" modified="2019-12-11" version="1">SLFPSLQYYEMSYGLNIEMHKQTEIAKRLNVICAQLIPFLSQEHQQQVVQAVERAKQVTMAELNAAIGHQLQAQHLPHSAPPIPLTPHPSGLASLGSASGLLALTGALAAPAQAGPKDDRGLADLEHRAPRPSRRPGAPRPLEART</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4B4</accession>
    <name>A0A5F8G4B4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">X-ray repair cross-complementing protein 5</fullName>
            <ecNumber evidence="14">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">XRCC5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Single-stranded DNA-dependent ATP-dependent helicase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4B4"/>
    <dbReference type="Ensembl" id="ENSMODT00000060890.1">
        <property type="protein sequence ID" value="ENSMODP00000042279.1"/>
        <property type="gene ID" value="ENSMODG00000015556.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153239"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015556">
        <property type="expression patterns" value="Expressed in hindlimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.240:FF:000001">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000005">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ku" evidence="16">
        <location>
            <begin position="270"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="688" mass="78420" checksum="EAC4522FA03DA666" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4B5</accession>
    <name>A0A5F8G4B5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Actin filament-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">110 kDa actin filament-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AFAP1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Monomer and homomultimer. Interacts via its C-terminus with F-actin; probably involving AFAP1 multimers. Interacts with activated SRC SH3-SH2 domains. Interacts via its PH 1 domain with PRKCA, PRKCB and PRKCI.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Stress fiber</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4B5"/>
    <dbReference type="Ensembl" id="ENSMODT00000084016.1">
        <property type="protein sequence ID" value="ENSMODP00000042303.1"/>
        <property type="gene ID" value="ENSMODG00000003012.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183067"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003012">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13306">
        <property type="entry name" value="PH1_AFAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13307">
        <property type="entry name" value="PH2_AFAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000122">
        <property type="entry name" value="Actin filament associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000020">
        <property type="entry name" value="Actin filament-associated protein 1-like 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030113">
        <property type="entry name" value="AFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14338:SF8">
        <property type="entry name" value="ACTIN FILAMENT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14338">
        <property type="entry name" value="ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="153"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="296"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="506"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="595"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="507"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="768" mass="85761" checksum="7FFBBA8E44842731" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4B6</accession>
    <name>A0A5F8G4B6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHD finger protein 21B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PHF21B</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4B6"/>
    <dbReference type="Ensembl" id="ENSMODT00000069520.1">
        <property type="protein sequence ID" value="ENSMODP00000042308.1"/>
        <property type="gene ID" value="ENSMODG00000010766.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161105"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010766">
        <property type="expression patterns" value="Expressed in cerebellum and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102:SF18">
        <property type="entry name" value="PHD FINGER PROTEIN 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="284" mass="30434" checksum="3C6A4154D7E48338" modified="2019-12-11" version="1">HYEGRNKHKKWLSTVPLLAFHVQEQSPPLQALGTIAAVPIKVPQVSSLHRLAGQGPAALPQVRPKTLIPDSLPISPCRERLSKQTATFQKATVVSIKNPSPALPISNNTVSQPGAEPAALASSLSGAGVAYAIISTSPSNAASSIKPNSATAATTVSMVSDSIKVQPLLISADNKVIIIQPQVQPQPDCKVETQKPSEESSQGAQASKKKREAPPEAQENPEKIAFMVALGLVTAEHLEEIQSKRQERKRRSTANPAYSGLLETERKRLASNYLNSPLFLSTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4B7</accession>
    <name>A0A5F8G4B7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Creatine kinase S-type, mitochondrial</fullName>
            <ecNumber evidence="2">2.7.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sarcomeric mitochondrial creatine kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CKMT2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Exists as an octamer composed of four CKMT2 homodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4B7"/>
    <dbReference type="Ensembl" id="ENSMODT00000068871.1">
        <property type="protein sequence ID" value="ENSMODP00000042296.1"/>
        <property type="gene ID" value="ENSMODG00000020259.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182772"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020259">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF19">
        <property type="entry name" value="CREATINE KINASE S-TYPE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="103"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="168" mass="19366" checksum="9738C57EE034F50D" modified="2019-12-11" version="1">MHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIKGRGWEFMWNERLGYVLTCPSNLGTGLRAGVHVRIPKLSKDPRFPKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4B9</accession>
    <name>A0A5F8G4B9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger protein 148</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ZNF148</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with HNRNPDL. Interacts with the 5FMC complex; the interaction requires association with CHTOP. Interacts with CAVIN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4B9"/>
    <dbReference type="Ensembl" id="ENSMODT00000054047.1">
        <property type="protein sequence ID" value="ENSMODP00000042297.1"/>
        <property type="gene ID" value="ENSMODG00000018374.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157406"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018374">
        <property type="expression patterns" value="Expressed in uterus and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000067">
        <property type="entry name" value="Vascular endothelial zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000042">
        <property type="entry name" value="Zinc finger protein 148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="308"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="827" mass="92413" checksum="6BC87196C625491E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4C2</accession>
    <name>A0A5F8G4C2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prostaglandin E2 receptor EP3 subtype</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Prostanoid EP3 receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PTGER3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts (via C-terminus) with MKLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4C2"/>
    <dbReference type="Ensembl" id="ENSMODT00000060165.1">
        <property type="protein sequence ID" value="ENSMODP00000042284.1"/>
        <property type="gene ID" value="ENSMODG00000003176.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234559"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003176">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004957">
        <property type="term" value="F:prostaglandin E receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000087">
        <property type="entry name" value="prostaglandin E2 receptor EP3 subtype"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001244">
        <property type="entry name" value="Prostglndn_DP_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000265">
        <property type="entry name" value="Prostglndn_EP3_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF10">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00428">
        <property type="entry name" value="PROSTAGLNDNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01788">
        <property type="entry name" value="PROSTANOIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00582">
        <property type="entry name" value="PRSTNOIDEP3R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="40"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="351" mass="38991" checksum="2C09AD4FDFA3112D" modified="2019-12-11" version="1">MWGSEPAAPPEPNNTDTWTTEEEGVSVAYPLVMMITGVLGNALSLLLVSRSYHHKESKGKKSFLLCIGGLALTELSGKLLTSPVVIAVYLSRKPWQQLDPSGHLCNFFGLTMTVVGICTLFISSTMAVERMLAIRAPHWYSIHLKTRDTGTVLLSVWLAGFTFALLPMASVGHYTIQWPGTWCFISIDEQGANATGSVYNLANVFFASTYAFLGLTALVVTFVCTLATIKALVSRCRTKATATQEDTHWVRITTETVIQLMGIVCVISACWSPLLIMMLKIIFNQTSMEHCKVLNSQVERPKECDLFLIAIRLASLNQILDPWVYLLLRKMLLCQIILNLHKWLSAKSGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4C5</accession>
    <name>A0A5F8G4C5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein-glutamine gamma-glutamyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TGM7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4C5"/>
    <dbReference type="Ensembl" id="ENSMODT00000067975.1">
        <property type="protein sequence ID" value="ENSMODP00000042306.1"/>
        <property type="gene ID" value="ENSMODG00000046174.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244866"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000046174">
        <property type="expression patterns" value="Expressed in spermatocyte and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000278">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000001">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF41">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="9">
        <location>
            <begin position="299"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="739" mass="83834" checksum="1B29AC1E9E1C526D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4C6</accession>
    <name>A0A5F8G4C6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4C6"/>
    <dbReference type="Ensembl" id="ENSMODT00000079423.1">
        <property type="protein sequence ID" value="ENSMODP00000042302.1"/>
        <property type="gene ID" value="ENSMODG00000050911.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111371"/>
    <dbReference type="OMA" id="VRCRIYL"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000050911">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15872">
        <property type="entry name" value="R-SNARE_VAMP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042166">
        <property type="entry name" value="Vamp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042581">
        <property type="entry name" value="VAMP5_R-SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47462">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47462:SF1">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="114" mass="12962" checksum="EC3950E924806759" modified="2019-12-11" version="1">MLAGKDLERCQRQADEVTEIMLNNFERVLVRDGKLAELEQRSDYFFLYLSFQSSAFSKTTKTLAQKKRWENIQWRVILGVVIGSILVVILITLLLSGTERAGDTKGPPAQTSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4C8</accession>
    <name>A0A5F8G4C8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SRR1 domain containing</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4C8"/>
    <dbReference type="Ensembl" id="ENSMODT00000081492.1">
        <property type="protein sequence ID" value="ENSMODP00000042290.1"/>
        <property type="gene ID" value="ENSMODG00000043414.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003948"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000043414">
        <property type="expression patterns" value="Expressed in spinal cord and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="3">
        <location>
            <begin position="157"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="367" mass="41246" checksum="064446AC4A36A0C6" modified="2019-12-11" version="1">MVRVAAPPGHAQDPPRSLPSSSQIPPPVPPPSLPLLCTLFPSPRLVAGYAGSCHGVMTSAAVSWRRPQLMNGGLSRSAGGGARDQPSCTWQTGTLRWAGMAMQYEGGSVRPELIQKCFTKPKDQLQESPEPISEVLEHLCLEPSQHPVEAPNSNLRKESLERTSHFKCVCYGIGKFASCVIARNQLAFLLLFLEKLQIPRNHCYIFDPLFNELEISVLNAFGLTVLNENEEGKRNICGEPTIFYMIHCGTALYNNLLWSNWSVDSLSKVMIIGNSFKGIEAKLLTRILQENYPYVAKILKGIEEIEFPQTSQYMDVFNDTAILWFPLQNLKEFPSEMWTFQDGPVYSETEELEIIRNKRKLTQPFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVA0</accession>
    <name>A0A5F8GVA0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SH3 domain containing GRB2 like 3, endophilin A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SH3GL3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVA0"/>
    <dbReference type="Ensembl" id="ENSMODT00000069934.1">
        <property type="protein sequence ID" value="ENSMODP00000051568.1"/>
        <property type="gene ID" value="ENSMODG00000019381.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157398"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019381">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11803">
        <property type="entry name" value="SH3_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035824">
        <property type="entry name" value="Endophilin_A_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF45">
        <property type="entry name" value="ENDOPHILIN-A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="11">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="297"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="363" mass="42126" checksum="48D8E0728714DF7B" modified="2019-12-11" version="1">MERKIDVTHRAFIELLPKCIEYLQPNPAYRMKLGVMQTVFKITGQLKNQPYPHSEGMLGDCMLRYGSELGEESLFVQKTVKVGLCNCGEGNTIPSFRFFIYLSSEWALTSLLSVLLRWSEVRRGQALLDCGETMMLMSDIKEALDINVKQNFLDPVQLLEAREIKDIERNLRKLESRRLDYDYIKRRDISIIHPEELQVAGGKFEESKELVRTSMTNFLENDIEQVNQLAVFIEALLEYHRQNTEILEDLYRKLHHRIRLSPYYYKSHADFLKTYKVKGNDRVEYRSSANSGPSFANVVPCCRGLYDFAAEHEEELGFKEGDIITITSQVDENWYAGILEGKYGFFPITYVEVLVPLPSHLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVA2</accession>
    <name>A0A5F8GVA2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multimerin 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVA2"/>
    <dbReference type="Ensembl" id="ENSMODT00000052796.1">
        <property type="protein sequence ID" value="ENSMODP00000051289.1"/>
        <property type="gene ID" value="ENSMODG00000011163.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100026747"/>
    <dbReference type="CTD" id="79812"/>
    <dbReference type="GeneTree" id="ENSGT01030000234633"/>
    <dbReference type="OrthoDB" id="8963519at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011163">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF6">
        <property type="entry name" value="MULTIMERIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07546">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023867552" evidence="8">
        <location>
            <begin position="20"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="10">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="9">
        <location>
            <begin position="834"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="660"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="790"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="970" mass="109055" checksum="5039EC411D9CC173" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVA3</accession>
    <name>A0A5F8GVA3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-box and WD repeat domain containing 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FBXW11</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007474070.1">
        <property type="nucleotide sequence ID" value="XM_007474008.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVA3"/>
    <dbReference type="Ensembl" id="ENSMODT00000055345.1">
        <property type="protein sequence ID" value="ENSMODP00000051465.1"/>
        <property type="gene ID" value="ENSMODG00000006464.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100031160"/>
    <dbReference type="CTD" id="23291"/>
    <dbReference type="GeneTree" id="ENSGT00940000155898"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006464">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22183">
        <property type="entry name" value="F-box_FBXW1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000001">
        <property type="entry name" value="F-box/WD repeat-containing protein 11 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000004">
        <property type="entry name" value="F-box/WD repeat-containing protein 11 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021977">
        <property type="entry name" value="Beta-TrCP_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF6">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN-CONTAINING 11-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12125">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01028">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="223"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="303"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="346"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="386"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="529" mass="60952" checksum="FF5AEC2E83183761" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVA4</accession>
    <name>A0A5F8GVA4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Roundabout guidance receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ROBO2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVA4"/>
    <dbReference type="Ensembl" id="ENSMODT00000083233.1">
        <property type="protein sequence ID" value="ENSMODP00000051437.1"/>
        <property type="gene ID" value="ENSMODG00000016811.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156324"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016811">
        <property type="expression patterns" value="Expressed in cerebellum and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05726">
        <property type="entry name" value="IgI_4_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20952">
        <property type="entry name" value="IgI_5_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000053">
        <property type="entry name" value="Roundabout guidance receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000055">
        <property type="entry name" value="roundabout homolog 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000065">
        <property type="entry name" value="roundabout homolog 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000008">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000043">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000058">
        <property type="entry name" value="roundabout homolog 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF242">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="102"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="191"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="294"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="401"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="514"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="616"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="910"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1018"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1089"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1123"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1204"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1275" mass="139049" checksum="1D958C80049DEAF2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVA5</accession>
    <name>A0A5F8GVA5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal RNA processing 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVA5"/>
    <dbReference type="Ensembl" id="ENSMODT00000078099.1">
        <property type="protein sequence ID" value="ENSMODP00000051136.1"/>
        <property type="gene ID" value="ENSMODG00000051346.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011821"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000051346">
        <property type="expression patterns" value="Expressed in testis and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF1">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 1 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="596" mass="66356" checksum="7CDA98026D85C978" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVA8</accession>
    <name>A0A5F8GVA8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capping protein regulator and myosin 1 linker 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CARMIL2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVA8"/>
    <dbReference type="Ensembl" id="ENSMODT00000062582.1">
        <property type="protein sequence ID" value="ENSMODP00000051470.1"/>
        <property type="gene ID" value="ENSMODG00000005734.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161003"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005734">
        <property type="expression patterns" value="Expressed in cerebellum and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031943">
        <property type="entry name" value="CARMIL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF32">
        <property type="entry name" value="CAPPING PROTEIN, ARP2_3 AND MYOSIN-I LINKER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16000">
        <property type="entry name" value="CARMIL_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARMIL C-terminal" evidence="2">
        <location>
            <begin position="654"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="CARMIL C-terminal" evidence="2">
        <location>
            <begin position="788"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1201" mass="129957" checksum="9FDB21F61FED8D5F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVA9</accession>
    <name>A0A5F8GVA9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RAB11B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVA9"/>
    <dbReference type="Ensembl" id="ENSMODT00000056606.1">
        <property type="protein sequence ID" value="ENSMODP00000051442.1"/>
        <property type="gene ID" value="ENSMODG00000003841.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163126"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003841">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="205" mass="22887" checksum="5F86E1D0AFB96C93" modified="2019-12-11" version="1">VVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADNNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIADRSAHDESPGNNVVDISVPPTTDGQKSNKLQCCQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVB4</accession>
    <name>A0A5F8GVB4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVB4"/>
    <dbReference type="Ensembl" id="ENSMODT00000075964.1">
        <property type="protein sequence ID" value="ENSMODP00000051447.1"/>
        <property type="gene ID" value="ENSMODG00000004798.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153222"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004798">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd06752">
        <property type="entry name" value="PDZ_PDZD11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="60"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="246" mass="27529" checksum="88477B530E2D81B4" modified="2019-12-11" version="1">MPVSVCAFSPSPDMEGQIPYDDYPVVFLPPYENPPAWIPPHERVYHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNEVDFQDIEHSKVRGAHPGYGKRTPSFVGLGNEEEPVAALGGACWPCFSFRSTSTFQAVEILKTAREISMRVRFFPYSKYRSHRPLALETLVLVVCNCRGAWLIELFSTRNWEERGRQSLSLERTVPCLPVGFSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVB5</accession>
    <name>A0A5F8GVB5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leukocyte receptor cluster member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LENG1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVB5"/>
    <dbReference type="Ensembl" id="ENSMODT00000082266.1">
        <property type="protein sequence ID" value="ENSMODP00000051146.1"/>
        <property type="gene ID" value="ENSMODG00000004039.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048131"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004039">
        <property type="expression patterns" value="Expressed in lung and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="243" mass="27976" checksum="4D2A27D3136A3BB3" modified="2019-12-11" version="1">MNILPKKSWHVRNKDNVARVRRDEAQAREEQRERERRALLAQQEARTDLLRKRARSHATPAPGPCVAREDPGPVDLFRELVEEGKGAGGGNREYEEEKRQEQERREKALGVLTYLGQSAAEAQTQPPWYQLPPEPRGTQCSPAPDEKVKSHLDPLRDLERQLGKKRKKQEGSGHSKARALPSSLEQLRAERLKREAAEQDTDQVLDGRPFRREQPQEEEGALTTAKRRYNSQFHPQLARPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVB6</accession>
    <name>A0A5F8GVB6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Ryanodine receptor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RYR3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000061207.1">
        <property type="protein sequence ID" value="ENSMODP00000051583.1"/>
        <property type="gene ID" value="ENSMODG00000001626.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155507"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001626">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12877">
        <property type="entry name" value="SPRY1_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12878">
        <property type="entry name" value="SPRY2_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000019">
        <property type="entry name" value="Ryanodine receptor 1 (skeletal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000009">
        <property type="entry name" value="Ryanodine receptor 1 (skeletal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000040">
        <property type="entry name" value="Ryanodine receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000001">
        <property type="entry name" value="Ryanodine receptor 2 (Cardiac)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000006">
        <property type="entry name" value="Ryanodine receptor 2 (Cardiac)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000017">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000003">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035761">
        <property type="entry name" value="SPRY1_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035764">
        <property type="entry name" value="SPRY2_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035762">
        <property type="entry name" value="SPRY3_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF9">
        <property type="entry name" value="RYANODINE RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4103"/>
            <end position="4127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4331"/>
            <end position="4351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4399"/>
            <end position="4418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4530"/>
            <end position="4548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4591"/>
            <end position="4612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="4671"/>
            <end position="4694"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="21">
        <location>
            <begin position="106"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="21">
        <location>
            <begin position="168"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="21">
        <location>
            <begin position="281"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="19">
        <location>
            <begin position="591"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="19">
        <location>
            <begin position="1223"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="3846"/>
            <end position="3874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="3470"/>
            <end position="3490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="3505"/>
            <end position="3530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="4208"/>
            <end position="4301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="3476"/>
            <end position="3485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="3520"/>
            <end position="3530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="4249"/>
            <end position="4279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="4790" mass="544929" checksum="00682D55D57D286C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVB7</accession>
    <name>A0A5F8GVB7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Cytosolic purine 5'-nucleotidase</fullName>
            <ecNumber evidence="21">2.7.1.77</ecNumber>
            <ecNumber evidence="4">3.1.3.5</ecNumber>
            <ecNumber evidence="5">3.1.3.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Cytosolic nucleoside phosphotransferase 5'N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="primary">NT5C2</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine. Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP. Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency. Through these activities regulates the purine nucleoside/nucleotide pools within the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>GMP + H2O = guanosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27714"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:27715"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:27719"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>XMP + H2O = xanthosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28530"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18107"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:28531"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate = a ribonucleoside + a 2'-deoxyribonucleoside 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19961"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="2.7.1.77"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:12485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>dGMP + H2O = 2'-deoxyguanosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29379"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:29380"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>dGMP + inosine = 2'-deoxyguanosine + IMP</text>
            <dbReference type="Rhea" id="RHEA:69580"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:57673"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>dIMP + H2O = 2'-deoxyinosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29383"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:29384"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>dIMP + inosine = 2'-deoxyinosine + IMP</text>
            <dbReference type="Rhea" id="RHEA:69572"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>inosine + AMP = IMP + adenosine</text>
            <dbReference type="Rhea" id="RHEA:69596"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>inosine + CMP = cytidine + IMP</text>
            <dbReference type="Rhea" id="RHEA:69592"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>inosine + GMP = guanosine + IMP</text>
            <dbReference type="Rhea" id="RHEA:69584"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>inosine + UMP = uridine + IMP</text>
            <dbReference type="Rhea" id="RHEA:69588"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="33">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="33">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.77" evidence="21"/>
    <dbReference type="EC" id="3.1.3.5" evidence="4"/>
    <dbReference type="EC" id="3.1.3.99" evidence="5"/>
    <dbReference type="RefSeq" id="XP_007479150.1">
        <property type="nucleotide sequence ID" value="XM_007479088.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVB7"/>
    <dbReference type="Ensembl" id="ENSMODT00000053972.1">
        <property type="protein sequence ID" value="ENSMODP00000051304.1"/>
        <property type="gene ID" value="ENSMODG00000011153.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022628"/>
    <dbReference type="CTD" id="22978"/>
    <dbReference type="GeneTree" id="ENSGT00940000163289"/>
    <dbReference type="OrthoDB" id="10252832at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011153">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050146">
        <property type="term" value="F:nucleoside phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046054">
        <property type="term" value="P:dGMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046037">
        <property type="term" value="P:GMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07522">
        <property type="entry name" value="HAD_cN-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000021">
        <property type="entry name" value="NT5C2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF17">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 33" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 33" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="34">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="32">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="32">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00038866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00040391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00042328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="529" mass="61166" checksum="6AF63F0C568A598C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVB8</accession>
    <name>A0A5F8GVB8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nexilin F-actin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NEXN</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVB8"/>
    <dbReference type="Ensembl" id="ENSMODT00000071804.1">
        <property type="protein sequence ID" value="ENSMODP00000051480.1"/>
        <property type="gene ID" value="ENSMODG00000020802.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111176"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020802">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508">
        <property type="entry name" value="MITOGUARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508:SF4">
        <property type="entry name" value="MITOGUARDIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="558"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="351"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="652" mass="76216" checksum="45C8B5B33D0924E0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVC1</accession>
    <name>A0A5F8GVC1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tectonin beta-propeller repeat containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TECPR2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000070810.1">
        <property type="protein sequence ID" value="ENSMODP00000051309.1"/>
        <property type="gene ID" value="ENSMODG00000013332.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157283"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013332">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056499">
        <property type="entry name" value="Beta-prop_HPS5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287">
        <property type="entry name" value="RUBY-EYE2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287:SF16">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23756">
        <property type="entry name" value="Beta-prop_HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06462">
        <property type="entry name" value="Hyd_WA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19193">
        <property type="entry name" value="Tectonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPS5-like beta-propeller" evidence="2">
        <location>
            <begin position="36"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1408" mass="156241" checksum="31D40DD11F5707B4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVC3</accession>
    <name>A0A5F8GVC3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CSNK1G2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_056676668.1">
        <property type="nucleotide sequence ID" value="XM_056820690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVC3"/>
    <dbReference type="Ensembl" id="ENSMODT00000056188.1">
        <property type="protein sequence ID" value="ENSMODP00000051485.1"/>
        <property type="gene ID" value="ENSMODG00000004527.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013960"/>
    <dbReference type="CTD" id="1455"/>
    <dbReference type="GeneTree" id="ENSGT00940000156470"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004527">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14126">
        <property type="entry name" value="STKc_CK1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001113">
        <property type="entry name" value="Casein kinase 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000018">
        <property type="entry name" value="Casein kinase I isoform gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022247">
        <property type="entry name" value="Casein_kinase-1_gamma_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12605">
        <property type="entry name" value="CK1gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="47"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="450" mass="51571" checksum="AC81786D136B4385" modified="2019-12-11" version="1">MDFDKRGGKGETEEGKRMAKTGGGRSTHHGCRNAGANSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGNTEGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHTIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRNGFVFDYEYDWAGKSLPTPIGTVHSEISTQPLNRDKSQVFPKHQVMSSTNGELNTDDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSTQRHKKRSKGASAQSVHESLPVKYHFFWSMCLAWLKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVC5</accession>
    <name>A0A5F8GVC5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Exocyst complex component Sec10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EXOC5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVC5"/>
    <dbReference type="Ensembl" id="ENSMODT00000057296.1">
        <property type="protein sequence ID" value="ENSMODP00000051156.1"/>
        <property type="gene ID" value="ENSMODG00000007734.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012837"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007734">
        <property type="expression patterns" value="Expressed in uterus and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="7">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="7">
        <location>
            <begin position="174"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="553" mass="63980" checksum="8991E5B8EF98992F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVC8</accession>
    <name>A0A5F8GVC8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription activation suppressor</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TASOR family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000069453.1">
        <property type="protein sequence ID" value="ENSMODP00000051462.1"/>
        <property type="gene ID" value="ENSMODG00000012365.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063735"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012365">
        <property type="expression patterns" value="Expressed in uterus and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22569">
        <property type="entry name" value="TASOR_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056242">
        <property type="entry name" value="PIN_TASOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046432">
        <property type="entry name" value="TASOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056243">
        <property type="entry name" value="TASOR_ab_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022188">
        <property type="entry name" value="TASOR_DUF3715"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207:SF1">
        <property type="entry name" value="PROTEIN TASOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12509">
        <property type="entry name" value="DUF3715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24630">
        <property type="entry name" value="PIN_TASOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23314">
        <property type="entry name" value="TASOR_alpha-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TASOR pseudo-PARP" evidence="3">
        <location>
            <begin position="162"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="TASOR alpha/beta" evidence="4">
        <location>
            <begin position="1230"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="domain" description="TASOR PIN" evidence="5">
        <location>
            <begin position="1328"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="958"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1450" mass="162535" checksum="CDD8C8C1568B1CE4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVC9</accession>
    <name>A0A5F8GVC9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Retinoid isomerohydrolase</fullName>
            <ecNumber evidence="18">3.1.1.64</ecNumber>
            <ecNumber evidence="17">5.3.3.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">All-trans-retinyl-palmitate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Lutein isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Meso-zeaxanthin isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Retinal pigment epithelium-specific 65 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Retinol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">RPE65</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31775"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16302"/>
            <dbReference type="ChEBI" id="CHEBI:17616"/>
            <dbReference type="EC" id="3.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31771"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16302"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:63410"/>
            <dbReference type="EC" id="3.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>lutein = (3R,3'S)-zeaxanthin</text>
            <dbReference type="Rhea" id="RHEA:12729"/>
            <dbReference type="ChEBI" id="CHEBI:28838"/>
            <dbReference type="ChEBI" id="CHEBI:138919"/>
            <dbReference type="EC" id="5.3.3.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="26">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="26">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with MYO7A; this mediates light-dependent intracellular transport of RPE65.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 27">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.64" evidence="18"/>
    <dbReference type="EC" id="5.3.3.22" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVC9"/>
    <dbReference type="FunCoup" id="A0A5F8GVC9">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051490"/>
    <dbReference type="Ensembl" id="ENSMODT00000081322.1">
        <property type="protein sequence ID" value="ENSMODP00000051490.1"/>
        <property type="gene ID" value="ENSMODG00000000710.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182913"/>
    <dbReference type="InParanoid" id="A0A5F8GVC9"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000710">
        <property type="expression patterns" value="Expressed in spermatid and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052884">
        <property type="term" value="F:all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001895">
        <property type="term" value="P:retina homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901827">
        <property type="term" value="P:zeaxanthin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF57">
        <property type="entry name" value="RETINOID ISOMEROHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 26" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12" id="KW-0844">Vision</keyword>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00040820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00042047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00042900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU003799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="556" mass="62887" checksum="CEFC1B99DC7DC4E2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVD1</accession>
    <name>A0A5F8GVD1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myelin-oligodendrocyte glycoprotein-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVD1"/>
    <dbReference type="Ensembl" id="ENSMODT00000069217.1">
        <property type="protein sequence ID" value="ENSMODP00000051161.1"/>
        <property type="gene ID" value="ENSMODG00000029705.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153527"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000029705">
        <property type="expression patterns" value="Expressed in blood and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05713">
        <property type="entry name" value="IgV_MOG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000183">
        <property type="entry name" value="Myelin-oligodendrocyte glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF71">
        <property type="entry name" value="MYELIN-OLIGODENDROCYTE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023815146" evidence="7">
        <location>
            <begin position="27"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="37"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="214" mass="24126" checksum="B25FCF57D82397C8" modified="2019-12-11" version="1">MEIVSSSGSFLSSFLIFLLLEKHTLASGRSIYFSLAPKGLSSGLSEQFSVIGPTEPIRAWVGRTADLPCYLSPQKNAQSMKVIWFQSLEIVHHYEDGQDKFDNQSPKFQGRTELVKDAISRGNVTLRIWNITAADKGHYKCHFDDGLYQEEAGIELLVSVLGEKRISCWVRTQCTRQQLCAVVTQHSSVKLKRYNGDCQFFRLLSLQPSHHSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVD2</accession>
    <name>A0A5F8GVD2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">FAT atypical cadherin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FAT2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000065736.1">
        <property type="protein sequence ID" value="ENSMODP00000051319.1"/>
        <property type="gene ID" value="ENSMODG00000009050.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158507"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009050">
        <property type="expression patterns" value="Expressed in cerebellum and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000013">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000015">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000021">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000026">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000032">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000037">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000041">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000051">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000052">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000064">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000065">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000071">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000075">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000079">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000080">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000089">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000194">
        <property type="entry name" value="FAT atypical cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000197">
        <property type="entry name" value="FAT atypical cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000215">
        <property type="entry name" value="FAT atypical cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000053">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000058">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000059">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000061">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000084">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000057">
        <property type="entry name" value="protocadherin Fat 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000178">
        <property type="entry name" value="Protocadherin Fat 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000035">
        <property type="entry name" value="Protocadherin Fat 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF37">
        <property type="entry name" value="PROTOCADHERIN FAT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023826798" evidence="17">
        <location>
            <begin position="22"/>
            <end position="4229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4025"/>
            <end position="4046"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="31"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="146"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="360"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="456"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="569"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="710"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="815"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="920"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1027"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1132"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1237"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1344"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1440"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1547"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1652"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1750"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1960"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="2062"/>
            <end position="2162"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="2163"/>
            <end position="2263"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="2264"/>
            <end position="2370"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="2371"/>
            <end position="2472"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="2473"/>
            <end position="2576"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="2577"/>
            <end position="2683"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="2684"/>
            <end position="2789"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="2790"/>
            <end position="2898"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="2899"/>
            <end position="3004"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="3005"/>
            <end position="3106"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="3107"/>
            <end position="3211"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="3212"/>
            <end position="3314"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="3323"/>
            <end position="3411"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="3412"/>
            <end position="3516"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="3723"/>
            <end position="3894"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="3897"/>
            <end position="3934"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="3924"/>
            <end position="3933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="4229" mass="465196" checksum="CEA4A294985A0676" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVD3</accession>
    <name>A0A5F8GVD3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BBSome complex member BBS4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BBS4</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
            <location evidence="3">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the BBS4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056654272.1">
        <property type="nucleotide sequence ID" value="XM_056798294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVD3"/>
    <dbReference type="FunCoup" id="A0A5F8GVD3">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051495"/>
    <dbReference type="Ensembl" id="ENSMODT00000074250.1">
        <property type="protein sequence ID" value="ENSMODP00000051495.1"/>
        <property type="gene ID" value="ENSMODG00000009951.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100028985"/>
    <dbReference type="CTD" id="585"/>
    <dbReference type="GeneTree" id="ENSGT00940000158166"/>
    <dbReference type="InParanoid" id="A0A5F8GVD3"/>
    <dbReference type="OMA" id="AGGMCEY"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009951">
        <property type="expression patterns" value="Expressed in spinal cord and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000242">
        <property type="term" value="C:pericentriolar material"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034452">
        <property type="term" value="F:dynactin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030534">
        <property type="term" value="P:adult behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001782">
        <property type="term" value="P:B cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048854">
        <property type="term" value="P:brain morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034101">
        <property type="term" value="P:erythrocyte homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060324">
        <property type="term" value="P:face development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060613">
        <property type="term" value="P:fat pad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021766">
        <property type="term" value="P:hippocampus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038108">
        <property type="term" value="P:negative regulation of appetite by leptin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003085">
        <property type="term" value="P:negative regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035845">
        <property type="term" value="P:photoreceptor cell outer segment organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903546">
        <property type="term" value="P:protein localization to photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060296">
        <property type="term" value="P:regulation of cilium beat frequency involved in ciliary motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902855">
        <property type="term" value="P:regulation of non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051492">
        <property type="term" value="P:regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046548">
        <property type="term" value="P:retinal rod cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120316">
        <property type="term" value="P:sperm flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021756">
        <property type="term" value="P:striatum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021591">
        <property type="term" value="P:ventricular system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000234">
        <property type="entry name" value="Bardet-Biedl syndrome 4 (Human)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000237">
        <property type="entry name" value="Bardet-Biedl syndrome 4 (Human)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000265">
        <property type="entry name" value="Bardet-Biedl syndrome 4 (Human)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186:SF1">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 18" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="534"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="584"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="621" mass="69456" checksum="31961B74FCF3854A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVD5</accession>
    <name>A0A5F8GVD5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RasGEF domain family member 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RASGEF1B</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVD5"/>
    <dbReference type="Ensembl" id="ENSMODT00000086285.1">
        <property type="protein sequence ID" value="ENSMODP00000051603.1"/>
        <property type="gene ID" value="ENSMODG00000011880.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155816"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011880">
        <property type="expression patterns" value="Expressed in heart and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.870.10:FF:000007">
        <property type="entry name" value="Ras-GEF domain-containing family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF197">
        <property type="entry name" value="RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="2">
        <location>
            <begin position="34"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="206" mass="24447" checksum="1DDE06CBC8285422" modified="2019-12-11" version="1">MPQTPPFAIMFDSSGYNRPLYPSKEDSYEGLYYQDNNLLSGSLEALIQHLVPSIDYYPDRTYIFTFLLSSRLFMHPFELMAKVCHLCIEHQRLSDPSLDKSQIRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLTHRIASGEEERLNYIGPEEFVQAFLQKDLLDNDKSCYDEPKKTRNLEAYVEWFNRLSYLVATEICMVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVD7</accession>
    <name>A0A5F8GVD7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVD7"/>
    <dbReference type="Ensembl" id="ENSMODT00000071309.1">
        <property type="protein sequence ID" value="ENSMODP00000051500.1"/>
        <property type="gene ID" value="ENSMODG00000039359.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000039314"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000039359">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12264">
        <property type="entry name" value="RRM_AKAP17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056852">
        <property type="entry name" value="AK17A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484">
        <property type="entry name" value="B-LYMPHOCYTE ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25015">
        <property type="entry name" value="RBD_AKAP-17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="150"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="912" mass="105035" checksum="BB287EC8587A384A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVD8</accession>
    <name>A0A5F8GVD8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Vesicle transport through interaction with t-SNAREs homolog 1B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">VTI1B</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="18">Forms a SNARE complex with STX7, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VIT1B that is required for heterotypic fusion of late endosomes with lysosomes. May interact with STX17. Interacts with CLINT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Early endosome membrane</location>
            <topology evidence="15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Late endosome membrane</location>
            <topology evidence="16">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Recycling endosome membrane</location>
            <topology evidence="17">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVD8"/>
    <dbReference type="Ensembl" id="ENSMODT00000064407.1">
        <property type="protein sequence ID" value="ENSMODP00000051472.1"/>
        <property type="gene ID" value="ENSMODG00000009992.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183192"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009992">
        <property type="expression patterns" value="Expressed in uterine wall and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15890">
        <property type="entry name" value="SNARE_Vti1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000003">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs homolog 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF89">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="21">
        <location>
            <begin position="130"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00062304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="214" mass="24523" checksum="3083684F28CF055F" modified="2019-12-11" version="1">MAVAVSSEPFEKLHDIFRGLYDDLRGVPERLLGTGGTEEKKKLIRDFDEKQQEANETLAEMEEELRFAPLSFRNPMMAKLRNYRRDLAKLQREVRNTPLTVMPGGRGDSKYGAYAVENEHMNRLQSQRVLLLQGTESLNRATQSIERSHRIATETDQIGAEIIEELGDQRDQLERTKSRLVNTNENLSKSRKILRSMSRNASAELWNAHYGTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVD9</accession>
    <name>A0A5F8GVD9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Solute carrier family 12 member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SLC12A7</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVD9"/>
    <dbReference type="Ensembl" id="ENSMODT00000071175.1">
        <property type="protein sequence ID" value="ENSMODP00000051324.1"/>
        <property type="gene ID" value="ENSMODG00000000878.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157657"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000878">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000049">
        <property type="entry name" value="Solute carrier family 12 (potassium/chloride transporter), member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000076">
        <property type="entry name" value="KCL_cotranspt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF47">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01081">
        <property type="entry name" value="KCLTRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="141"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="435"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="516"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="677"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="794" mass="87591" checksum="ABA2F5A97EA2878A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVE0</accession>
    <name>A0A5F8GVE0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amyloid beta protein binding family A member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">APBA2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVE0"/>
    <dbReference type="Ensembl" id="ENSMODT00000084409.1">
        <property type="protein sequence ID" value="ENSMODP00000051608.1"/>
        <property type="gene ID" value="ENSMODG00000011835.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158943"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011835">
        <property type="expression patterns" value="Expressed in cerebellum and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd06720">
        <property type="entry name" value="PDZ1_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01208">
        <property type="entry name" value="PTB_X11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000044">
        <property type="entry name" value="amyloid beta A4 precursor protein-binding family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000017">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF12">
        <property type="entry name" value="AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PID" evidence="5">
        <location>
            <begin position="371"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="571"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="683" mass="76417" checksum="4B1CDDFA8B6B1FE3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVE1</accession>
    <name>A0A5F8GVE1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Roundabout guidance receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ROBO2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVE1"/>
    <dbReference type="Ensembl" id="ENSMODT00000074842.1">
        <property type="protein sequence ID" value="ENSMODP00000051171.1"/>
        <property type="gene ID" value="ENSMODG00000016811.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156324"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016811">
        <property type="expression patterns" value="Expressed in cerebellum and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05726">
        <property type="entry name" value="IgI_4_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20952">
        <property type="entry name" value="IgI_5_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000053">
        <property type="entry name" value="Roundabout guidance receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000055">
        <property type="entry name" value="roundabout homolog 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000065">
        <property type="entry name" value="roundabout homolog 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000008">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000043">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000058">
        <property type="entry name" value="roundabout homolog 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF242">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="102"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="195"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="298"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="405"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="518"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="620"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="914"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1068"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1127"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1208"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1279" mass="139473" checksum="DCAD486779167B70" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVE2</accession>
    <name>A0A5F8GVE2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear receptor corepressor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NCOR1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-CoR nuclear receptor corepressors family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000070523.1">
        <property type="protein sequence ID" value="ENSMODP00000051505.1"/>
        <property type="gene ID" value="ENSMODG00000011198.6"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155093"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011198">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1880:FF:000004">
        <property type="entry name" value="nuclear receptor corepressor 1 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000001">
        <property type="entry name" value="Nuclear receptor corepressor 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031557">
        <property type="entry name" value="N-CoR_GPS2_interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF5">
        <property type="entry name" value="NUCLEAR RECEPTOR COREPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15784">
        <property type="entry name" value="GPS2_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="279"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="466"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="469"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="473"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1294"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1538"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1682"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1794"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1922"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2141"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1297"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1334"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1557"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1684"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1707"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1730"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1754"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1803"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1876"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1922"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1953"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1978"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2147"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2278"/>
            <end position="2290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2290" mass="251689" checksum="606D840BB501AA96" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVE4</accession>
    <name>A0A5F8GVE4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Bromodomain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BRD8</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVE4"/>
    <dbReference type="Ensembl" id="ENSMODT00000063521.1">
        <property type="protein sequence ID" value="ENSMODP00000051176.1"/>
        <property type="gene ID" value="ENSMODG00000012223.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064262"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012223">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05507">
        <property type="entry name" value="Bromo_brd8_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000016">
        <property type="entry name" value="bromodomain-containing protein 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037966">
        <property type="entry name" value="Brd8_Bromo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF13">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 14" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="776"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="1174"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="119"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="628"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="952"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1018"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="883"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1018"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1046"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1065"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1096"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1275" mass="138310" checksum="F3FA349198CEF369" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVE7</accession>
    <name>A0A5F8GVE7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transmembrane protein 132D</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM132 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVE7"/>
    <dbReference type="Ensembl" id="ENSMODT00000080265.1">
        <property type="protein sequence ID" value="ENSMODP00000051510.1"/>
        <property type="gene ID" value="ENSMODG00000045547.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158942"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000045547">
        <property type="expression patterns" value="Expressed in spinal cord and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031437">
        <property type="entry name" value="Ig_TMEM132_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055423">
        <property type="entry name" value="Ig_TMEM132_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055424">
        <property type="entry name" value="Ig_TMEM132_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026307">
        <property type="entry name" value="TMEM132"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031436">
        <property type="entry name" value="TMEM132_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13388">
        <property type="entry name" value="DETONATOR, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13388:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 132D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16070">
        <property type="entry name" value="Ig_TMEM132_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23486">
        <property type="entry name" value="Ig_TMEM132_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23487">
        <property type="entry name" value="Ig_TMEM132_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15706">
        <property type="entry name" value="TMEM132_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein family 132 fourth" evidence="9">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 fifth" evidence="10">
        <location>
            <begin position="57"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 sixth" evidence="11">
        <location>
            <begin position="194"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 C-terminal" evidence="8">
        <location>
            <begin position="418"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="70601" checksum="B56885498388A9FD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVF0</accession>
    <name>A0A5F8GVF0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CLCN7</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVF0"/>
    <dbReference type="Ensembl" id="ENSMODT00000085367.1">
        <property type="protein sequence ID" value="ENSMODP00000051334.1"/>
        <property type="gene ID" value="ENSMODG00000016179.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158458"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016179">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062158">
        <property type="term" value="F:chloride:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03685">
        <property type="entry name" value="ClC_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000018">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002249">
        <property type="entry name" value="CIC-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF136">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01118">
        <property type="entry name" value="CLCHANNEL7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="661"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="725" mass="80465" checksum="D86160EAE1EF5BCD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVF1</accession>
    <name>A0A5F8GVF1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RELT like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RELL2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RELT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVF1"/>
    <dbReference type="FunCoup" id="A0A5F8GVF1">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051181"/>
    <dbReference type="Ensembl" id="ENSMODT00000079491.1">
        <property type="protein sequence ID" value="ENSMODP00000051181.1"/>
        <property type="gene ID" value="ENSMODG00000010603.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160541"/>
    <dbReference type="InParanoid" id="A0A5F8GVF1"/>
    <dbReference type="OMA" id="IPCAHEG"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010603">
        <property type="expression patterns" value="Expressed in cerebellum and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900745">
        <property type="term" value="P:positive regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042313">
        <property type="entry name" value="RELL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022248">
        <property type="entry name" value="TNF_rcpt_RELT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31481:SF0">
        <property type="entry name" value="RELT-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31481">
        <property type="entry name" value="RELT-LIKE PROTEIN 2 RELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12606">
        <property type="entry name" value="RELT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="306" mass="33128" checksum="544A8569BED14EF0" modified="2019-12-11" version="1">MSELQPGPEPQHGLYMLFLLVLVFFLMGLVGFMICHVLKKKGYRCRTSRGSEPEDAQLQPPDDEDMNEDTVERIVQCIIQNEANAEALKEMLGDSEGEATVQLSSLDGAPSLQDGTPSHHHTVHLGSAAPCIHCSRNKRPPLIRQGRSKEGKGRTRPGETTVFSVGRFRVTHIEKRFGLHEHRDGSPTDRSWGSSGGQDPGGGQGSGKGQIGPGTPATERLPASGPEAGVLSSPPIQNGNVRERSLTPSLIERPSGTMEDLEAAARERDTRPVLSRRETNGQPAKLDASDLQVGNSHMYVYGNQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVF7</accession>
    <name>A0A5F8GVF7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBX domain protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">UBXN1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVF7"/>
    <dbReference type="Ensembl" id="ENSMODT00000072776.1">
        <property type="protein sequence ID" value="ENSMODP00000051520.1"/>
        <property type="gene ID" value="ENSMODG00000050228.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156457"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000050228">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="102" mass="11338" checksum="EC5F3ADBBD18EA9C" modified="2019-12-11" version="1">MRRAAEERRREKAEETAARQRVREKIERDKVERAKKFGGTGSQMTSTATEPGPVPSSPSQEPPTKREYDQCRIQDSCLLLSSLPRSVPAEGVSSLLSSPLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVF9</accession>
    <name>A0A5F8GVF9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Folliculin interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FNIP2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FNIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVF9"/>
    <dbReference type="Ensembl" id="ENSMODT00000060803.1">
        <property type="protein sequence ID" value="ENSMODP00000051344.1"/>
        <property type="gene ID" value="ENSMODG00000002053.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009391"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002053">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037545">
        <property type="entry name" value="DENN_FNIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028086">
        <property type="entry name" value="FNIP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026156">
        <property type="entry name" value="FNIP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028085">
        <property type="entry name" value="FNIP_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF11">
        <property type="entry name" value="FOLLICULIN-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14638">
        <property type="entry name" value="FNIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14637">
        <property type="entry name" value="FNIP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02073">
        <property type="entry name" value="FOLLICULNIP1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51836">
        <property type="entry name" value="DENN_FNIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FNIP1/2-type" evidence="8">
        <location>
            <begin position="45"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="583"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1088" mass="119768" checksum="3C2C5C9E536A1484" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7A0</accession>
    <name>A0A5F8H7A0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho guanine nucleotide exchange factor 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Collybistin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Rac/Cdc42 guanine nucleotide exchange factor 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ARHGEF9</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with GPHN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056664799.1">
        <property type="nucleotide sequence ID" value="XM_056808821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7A0"/>
    <dbReference type="Ensembl" id="ENSMODT00000070713.1">
        <property type="protein sequence ID" value="ENSMODP00000055101.1"/>
        <property type="gene ID" value="ENSMODG00000020843.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100018406"/>
    <dbReference type="CTD" id="23229"/>
    <dbReference type="GeneTree" id="ENSGT00940000154103"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020843">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01224">
        <property type="entry name" value="PH_Collybistin_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11975">
        <property type="entry name" value="SH3_ARHGEF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000002">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000015">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000037">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035728">
        <property type="entry name" value="ARHGEF9_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544:SF4">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="16">
        <location>
            <begin position="110"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="325"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="523" mass="61580" checksum="4CA3A44083AC7BE8" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7A1</accession>
    <name>A0A5F8H7A1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane serine protease 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TMPRSS7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7A1"/>
    <dbReference type="Ensembl" id="ENSMODT00000080796.1">
        <property type="protein sequence ID" value="ENSMODP00000055424.1"/>
        <property type="gene ID" value="ENSMODG00000018097.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160085"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018097">
        <property type="expression patterns" value="Expressed in spermatid and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033223">
        <property type="entry name" value="TTMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14636">
        <property type="entry name" value="TPA-INDUCED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14636:SF1">
        <property type="entry name" value="TPA-INDUCED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="244" mass="27549" checksum="49F6DE6216CA9F7C" modified="2019-12-11" version="1">MCFYIWNCYCPDALCRCNVREERCLQSGGRLPAPADAMIQLAELRVHPEEAVPLSGRVPQENVLQVEDPEAAQARRQNSWKFCKRPVKGKYKLWMAVASLFIGFILMIIIVILIHEVTYSDEDENEIFELSFNKTFLVTLKIPEPCMAKEDSLSNELNERLRSLYSSSPALSRYFASVEIAGSSSNNSTMAYHLNFVAPSEDGLFMEYMMSKELVLGILRQNFHDQSVVGCETLGTDPASLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7A3</accession>
    <name>A0A5F8H7A3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH:ubiquinone oxidoreductase complex assembly factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NDUFAF6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7A3"/>
    <dbReference type="Ensembl" id="ENSMODT00000052846.1">
        <property type="protein sequence ID" value="ENSMODP00000055828.1"/>
        <property type="gene ID" value="ENSMODG00000006988.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156408"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006988">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01218">
        <property type="entry name" value="PH_Phafin2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000167">
        <property type="entry name" value="Pleckstrin homology domain-containing family F member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051765">
        <property type="entry name" value="PH_domain-containing_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037871">
        <property type="entry name" value="PH_Phafin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280:SF1">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="259" mass="28933" checksum="810D7DE6CE8FECA6" modified="2019-12-11" version="1">MVDRLANSEANTRRISIVENCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTPSNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPNDFLAIFPWPKYKWSGHFRENPGKESAFSLTTCQSKGRDVRTASPGTGSQVQSADSFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7A7</accession>
    <name>A0A5F8H7A7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain containing 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CCDC68</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7A7"/>
    <dbReference type="Ensembl" id="ENSMODT00000054972.1">
        <property type="protein sequence ID" value="ENSMODP00000055677.1"/>
        <property type="gene ID" value="ENSMODG00000020457.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183065"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020457">
        <property type="expression patterns" value="Expressed in spermatid and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051375">
        <property type="entry name" value="Tuftelin_GRINL1A/MYZAP/CCD68"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171:SF3">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171">
        <property type="entry name" value="GDOWN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="326" mass="37958" checksum="06ECFF474089A3A3" modified="2019-12-11" version="1">MTTLLMTSEALQDMLTAEEDNLMLCKSKSAHISEETEYVRKLRTMLEDIRHQIFKDELDHKIPQHTSCSKSCCCNTEYESEGKAKISPCGFNLIMEKMKDKDLQLQEMNKENEFLKIKLEASREAGAAALRSVAKKLFGDYEKQREELRKKHEDEKKLLQVNNFEKEKIYKQHVECLKQVTERLGGKHCQIAKLENLVQKMEEEKKLLLEKKACLQFKLDQLLLNSKDAKSCKDLQTEISTLQRQISCLQFVIYSQHQNLRSVIQEMEGLKNDLQEQDKMIETLKEKVNVLEAQNKDLKNKIKLWSECSKTKVSKGVCTRNFGTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7A8</accession>
    <name>A0A5F8H7A8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PCNX2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the pecanex family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000052554.1">
        <property type="protein sequence ID" value="ENSMODP00000055833.1"/>
        <property type="gene ID" value="ENSMODG00000008590.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157374"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008590">
        <property type="expression patterns" value="Expressed in cerebellum and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039797">
        <property type="entry name" value="Pecanex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007735">
        <property type="entry name" value="Pecanex_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372">
        <property type="entry name" value="PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372:SF5">
        <property type="entry name" value="PECANEX-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05041">
        <property type="entry name" value="Pecanex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="848"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="960"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1294"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="domain" description="Pecanex C-terminal" evidence="8">
        <location>
            <begin position="1590"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="618"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1846"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1865"/>
            <end position="1875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2106" mass="235446" checksum="9D12CA01D761F557" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7A9</accession>
    <name>A0A5F8H7A9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">KIAA0825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">KIAA0825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7A9"/>
    <dbReference type="Ensembl" id="ENSMODT00000085482.1">
        <property type="protein sequence ID" value="ENSMODP00000055870.1"/>
        <property type="gene ID" value="ENSMODG00000020128.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00610000086112"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020128">
        <property type="expression patterns" value="Expressed in spermatocyte and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027993">
        <property type="entry name" value="DUF4495"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960:SF1">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14906">
        <property type="entry name" value="DUF4495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1262" mass="145266" checksum="F9104FEFAF21D93E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7B0</accession>
    <name>A0A5F8H7B0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDHD domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DDHD1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA-PLA1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7B0"/>
    <dbReference type="Ensembl" id="ENSMODT00000074660.1">
        <property type="protein sequence ID" value="ENSMODP00000055111.1"/>
        <property type="gene ID" value="ENSMODG00000013016.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156065"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013016">
        <property type="expression patterns" value="Expressed in spermatid and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF32">
        <property type="entry name" value="PHOSPHOLIPASE DDHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="3">
        <location>
            <begin position="641"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="905" mass="101558" checksum="97CBF4E157EB8C5A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7B3</accession>
    <name>A0A5F8H7B3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TBC1 domain family member 22A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TBC1D22A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007502573.1">
        <property type="nucleotide sequence ID" value="XM_007502511.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7B3"/>
    <dbReference type="Ensembl" id="ENSMODT00000081542.1">
        <property type="protein sequence ID" value="ENSMODP00000055682.1"/>
        <property type="gene ID" value="ENSMODG00000015752.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100023546"/>
    <dbReference type="KEGG" id="mdo:100023546"/>
    <dbReference type="CTD" id="25771"/>
    <dbReference type="GeneTree" id="ENSGT00940000159840"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015752">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000009">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000004">
        <property type="entry name" value="TBC1 domain family, member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF255">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="305"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="599" mass="68697" checksum="A770C9DB6BDBF1EA" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7B6</accession>
    <name>A0A5F8H7B6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">GRIK1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15 19">Postsynaptic cell membrane</location>
            <topology evidence="15 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7B6"/>
    <dbReference type="Ensembl" id="ENSMODT00000085972.1">
        <property type="protein sequence ID" value="ENSMODP00000055439.1"/>
        <property type="gene ID" value="ENSMODG00000020977.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156253"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020977">
        <property type="expression patterns" value="Expressed in cerebellum and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06382">
        <property type="entry name" value="PBP1_iGluR_Kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000210">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000240">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 19" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7 19" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="743"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="20">
        <location>
            <begin position="356"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
        <location>
            <begin position="366"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="17">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="17">
        <location>
            <position position="618"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="31"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="673"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU367118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="826" mass="93403" checksum="E80E305E64B793EB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7B7</accession>
    <name>A0A5F8H7B7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7B7"/>
    <dbReference type="Ensembl" id="ENSMODT00000076653.1">
        <property type="protein sequence ID" value="ENSMODP00000055121.1"/>
        <property type="gene ID" value="ENSMODG00000014728.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164042"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014728">
        <property type="expression patterns" value="Expressed in blood and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000012">
        <property type="entry name" value="CD163 molecule like 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000031">
        <property type="entry name" value="RIKEN cDNA 5830411N06, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000002">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000004">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000009">
        <property type="entry name" value="WC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF15">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023888821" description="SRCR domain-containing protein" evidence="13">
        <location>
            <begin position="17"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="120"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="222"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="351"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="457"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="561"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="663"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="765"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="880"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="986"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="1104"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="55"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="145"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="158"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="247"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="260"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="377"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="390"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="585"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="598"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="688"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="701"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="790"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="803"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="906"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="919"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1129"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1142"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1173"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1264" mass="137727" checksum="6B52973595C08FA7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7B8</accession>
    <name>A0A5F8H7B8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Golgi SNAP receptor complex member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GOSR2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
            <location evidence="9">cis-Golgi network membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GOSR2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016286058.1">
        <property type="nucleotide sequence ID" value="XM_016430572.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7B8"/>
    <dbReference type="Ensembl" id="ENSMODT00000074583.1">
        <property type="protein sequence ID" value="ENSMODP00000055843.1"/>
        <property type="gene ID" value="ENSMODG00000011089.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100024635"/>
    <dbReference type="CTD" id="9570"/>
    <dbReference type="GeneTree" id="ENSGT00950000183192"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011089">
        <property type="expression patterns" value="Expressed in uterine wall and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000004">
        <property type="entry name" value="Golgi SNAP receptor complex member 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="165" mass="19590" checksum="6D26D5D92E96BCCF" modified="2019-12-11" version="1">MEPLYQQTHKQVHEIQSHMGRLETSDKESLHLVENEIQARIDQIFSSLERLEILSSKEPPNKRQNAKLRVDQLKYDVQHLQTALRNFQHRRYAREQQERQREELLSRTFTTNGTQKKILDIANMLGLSNTVMRLIEKRAFQDKYFMIGGMLLTCVVMFLVVQYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7C0</accession>
    <name>A0A5F8H7C0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Histone deacetylase</fullName>
            <ecNumber evidence="3 13">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HDAC9</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 13"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7C0"/>
    <dbReference type="Ensembl" id="ENSMODT00000055054.1">
        <property type="protein sequence ID" value="ENSMODP00000055880.1"/>
        <property type="gene ID" value="ENSMODG00000001442.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160307"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001442">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10163">
        <property type="entry name" value="ClassIIa_HDAC9_Gln-rich-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11681">
        <property type="entry name" value="HDAC_classIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000002">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046949">
        <property type="entry name" value="HDAC4/5/7/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024643">
        <property type="entry name" value="Hist_deacetylase_Gln_rich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45364:SF11">
        <property type="entry name" value="HISTONE DEACETYLASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45364">
        <property type="entry name" value="HISTONE DEACETYLASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12203">
        <property type="entry name" value="HDAC4_Gln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037911">
        <property type="entry name" value="HDAC_II_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Histone deacetylase glutamine rich N-terminal" evidence="19">
        <location>
            <begin position="56"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="18">
        <location>
            <begin position="548"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="205"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="284"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="938"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="677"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Contributes to catalysis" evidence="16">
        <location>
            <position position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="959" mass="105828" checksum="E301DA1EC4708C23" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7C2</accession>
    <name>A0A5F8H7C2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger matrin-type 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZMAT4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7C2"/>
    <dbReference type="Ensembl" id="ENSMODT00000071376.1">
        <property type="protein sequence ID" value="ENSMODP00000055126.1"/>
        <property type="gene ID" value="ENSMODG00000010499.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156888"/>
    <dbReference type="OMA" id="RVAHYEX"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010499">
        <property type="expression patterns" value="Expressed in spinal cord and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051868">
        <property type="entry name" value="ZN346_ZMAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46144:SF3">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46144">
        <property type="entry name" value="ZINC FINGER PROTEIN 385B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="221" mass="24836" checksum="A25F79A8E635B3BD" modified="2019-12-11" version="1">MLSIFFQSRKHASKVRLYYMLHPVDGGCPAKKLRSENGSDDDMVDKNKCCTLCNMSFTSAVVADSHYQGKIHAKRLKLLLGEQPPVKAAGNAGKEQRVEHNEATQLEELRETPLSPLKPPHSASAPGVPVSSPHRRRDSDRYCQLCAAWFNNPLMAQQHYEGKKHKKNAARVDLLEQLGKTLDLGELRGLRRSYTCSICHVTLNSIEQYHAHLKGSKHQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7C4</accession>
    <name>A0A5F8H7C4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">EMAP like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EML5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat EMAP family.</text>
    </comment>
    <dbReference type="FunCoup" id="A0A5F8H7C4">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055692"/>
    <dbReference type="Ensembl" id="ENSMODT00000073327.1">
        <property type="protein sequence ID" value="ENSMODP00000055692.1"/>
        <property type="gene ID" value="ENSMODG00000003165.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156613"/>
    <dbReference type="InParanoid" id="A0A5F8H7C4"/>
    <dbReference type="OMA" id="AVAPCLE"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003165">
        <property type="expression patterns" value="Expressed in cerebellum and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000040">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000042">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000044">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000024">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000035">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000037">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF16">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="53"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="328"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="719"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="899"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="1411"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="1702"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1702"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1277"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1281"/>
            <end position="1294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1974" mass="220429" checksum="B49A9F428B3F4177" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7C6</accession>
    <name>A0A5F8H7C6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CD53 molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CD53</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7C6"/>
    <dbReference type="FunCoup" id="A0A5F8H7C6">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055131"/>
    <dbReference type="Ensembl" id="ENSMODT00000088921.1">
        <property type="protein sequence ID" value="ENSMODP00000055131.1"/>
        <property type="gene ID" value="ENSMODG00000001578.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159669"/>
    <dbReference type="InParanoid" id="A0A5F8H7C6"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001578">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF39">
        <property type="entry name" value="LEUKOCYTE SURFACE ANTIGEN CD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="305" mass="34637" checksum="69FD7EB73367CB5C" modified="2019-12-11" version="1">MAVESRKYSNSTTLTGKSEGRVKATAVDALLTGHNYLHVVSFKFKYQDHSSMSMSSLKVLKYVVFFFNLLFWVCGCTILGFGIYFLIKNSFGSLFYSLPSLTLGNVVIIVGSIIMVIAFLGCMGSIKENKCLLMSFFILLLFILLMEVIMAILLFAYEQKIDHYVANDLSQSIQRYKSDNNTKMAWDEIQQHLECCGVNSTSDWKGHLPESCPKDPKTQVTLVIFSCLFLFGESRIALEITKYCDTLSHNAPSQSQQVKGHNKRGTDLQYFIHSFIHSFIHSFIHSFTHSLIHLFIYRPIPIPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7C8</accession>
    <name>A0A5F8H7C8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Basigin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Basolateral cell membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7C8"/>
    <dbReference type="Ensembl" id="ENSMODT00000066331.1">
        <property type="protein sequence ID" value="ENSMODP00000055449.1"/>
        <property type="gene ID" value="ENSMODG00000006517.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159142"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006517">
        <property type="expression patterns" value="Expressed in placenta and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000387">
        <property type="entry name" value="Neuroplastin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF107">
        <property type="entry name" value="BASIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01856">
        <property type="entry name" value="BASIGIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0465">Mannose-binding</keyword>
    <keyword evidence="5 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="98"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="267" mass="29912" checksum="1C659892657E1B3A" modified="2019-12-11" version="1">MMVSPPNPFVIYLTNFALFFFKIVGNNIWTAIDVSSHRTLLTCEGHRWLKGDKVLKEDKSDSLTTEYEVVSDDRSGEYQCIFLPELAGKADVQVKGPPKVYINKKSEYGNEGDSIVLTCKSSSYPSIEQWKWYKENEGEANMILVNDTEGRMSIISTPEKTELHINSADIKEDPGKYICNGTNSEGSDTAVITLKVRSRLAALWPFLGIVAEVLILVIIIFIYERRRRTDDIVEAEPPRDEDGGAAPLKASSAVNEKGSNIRQRNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7D0</accession>
    <name>A0A5F8H7D0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NUP107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7D0"/>
    <dbReference type="Ensembl" id="ENSMODT00000063920.1">
        <property type="protein sequence ID" value="ENSMODP00000055890.1"/>
        <property type="gene ID" value="ENSMODG00000007267.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012080"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007267">
        <property type="expression patterns" value="Expressed in spermatid and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="377" mass="42281" checksum="C0786BA2090D5279" modified="2019-12-11" version="1">MDSGSCFGEMASPMVRDVEVTRTARRQSAHKRVSILTPQEDILANATPRNQMIPRTPNSHCQTLFRSLLRQPDVSAILATGTKSPRLAPLSTSLGNLPMTTNLDESNWTANFSPQRSGIFANNEPSNMTEDVTLSAVMLREDDPGEAATMSMYSDFLHTFLKHASNTVFELIEEYENICESQVNILSKIASRATPGLQKFSKTASVLWLLQQEMVTWRLLASLYKDRIQSVLEEENAFAIASLNASEKTVVDTLFQRDSLIRQSQLVVDWLESIAKDDIGDFSDNIEFYAKSVYWENTLHTLKQRQLISFIGSVRPLVTELAILWGGACGISFLSCWFLSLRAWLYLSISWSLASRSLRGDVKQGDIMESEILFSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7D3</accession>
    <name>A0A5F8H7D3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dysferlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DYSF</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferlin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000062163.1">
        <property type="protein sequence ID" value="ENSMODP00000055454.1"/>
        <property type="gene ID" value="ENSMODG00000010868.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156187"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010868">
        <property type="expression patterns" value="Expressed in heart and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08373">
        <property type="entry name" value="C2A_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000021">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000026">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000061">
        <property type="entry name" value="dysferlin isoform X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037726">
        <property type="entry name" value="C2A_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012560">
        <property type="entry name" value="Ferlin_A-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF44">
        <property type="entry name" value="DYSFERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08165">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01200">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1651"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="797"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="953"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1202"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1436"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1610"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1685" mass="191598" checksum="40BD4E7BEBB7B1CD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7D4</accession>
    <name>A0A5F8H7D4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polypyrimidine tract-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PTBP3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7D4"/>
    <dbReference type="Ensembl" id="ENSMODT00000079820.1">
        <property type="protein sequence ID" value="ENSMODP00000055702.1"/>
        <property type="gene ID" value="ENSMODG00000005502.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244924"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005502">
        <property type="expression patterns" value="Expressed in uterus and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903312">
        <property type="term" value="P:negative regulation of mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12779">
        <property type="entry name" value="RRM1_ROD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12693">
        <property type="entry name" value="RRM2_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000036">
        <property type="entry name" value="polypyrimidine tract-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000162">
        <property type="entry name" value="polypyrimidine tract-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000018">
        <property type="entry name" value="Polypyrimidine tract-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000032">
        <property type="entry name" value="Polypyrimidine tract-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006536">
        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055204">
        <property type="entry name" value="HNRNPL_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034326">
        <property type="entry name" value="ROD1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22976">
        <property type="entry name" value="RRM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="70"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="193"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="369"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="486"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="563" mass="61214" checksum="16246B4D83FD50DE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7D5</accession>
    <name>A0A5F8H7D5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MTMR4</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="3"/>
    <dbReference type="RefSeq" id="XP_007481875.1">
        <property type="nucleotide sequence ID" value="XM_007481813.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007481876.1">
        <property type="nucleotide sequence ID" value="XM_007481814.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007481877.1">
        <property type="nucleotide sequence ID" value="XM_007481815.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007481878.1">
        <property type="nucleotide sequence ID" value="XM_007481816.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056670188.1">
        <property type="nucleotide sequence ID" value="XM_056814210.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056670189.1">
        <property type="nucleotide sequence ID" value="XM_056814211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7D5"/>
    <dbReference type="Ensembl" id="ENSMODT00000057768.1">
        <property type="protein sequence ID" value="ENSMODP00000055895.1"/>
        <property type="gene ID" value="ENSMODG00000014697.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100012210"/>
    <dbReference type="CTD" id="9110"/>
    <dbReference type="GeneTree" id="ENSGT00940000158976"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014697">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15733">
        <property type="entry name" value="FYVE_MTMR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13342">
        <property type="entry name" value="PH-GRAM_MTMR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14587">
        <property type="entry name" value="PTP-MTMR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000073">
        <property type="entry name" value="myotubularin-related protein 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046978">
        <property type="entry name" value="MTMR4_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035997">
        <property type="entry name" value="MTMR4_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030590">
        <property type="entry name" value="MTMR4_PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF64">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="17">
        <location>
            <begin position="153"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="376"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="16">
        <location>
            <begin position="1120"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="725"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="345"/>
            <end position="346"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="407"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134977" checksum="CDCC6D07F715FCD2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7D6</accession>
    <name>A0A5F8H7D6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Fibroblast growth factor receptor</fullName>
            <ecNumber evidence="20">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">FGFR3</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7D6"/>
    <dbReference type="Ensembl" id="ENSMODT00000074738.1">
        <property type="protein sequence ID" value="ENSMODP00000055141.1"/>
        <property type="gene ID" value="ENSMODG00000004268.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159880"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004268">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005007">
        <property type="term" value="F:fibroblast growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05857">
        <property type="entry name" value="IgI_2_FGFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05858">
        <property type="entry name" value="IgI_3_FGFR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05100">
        <property type="entry name" value="PTKc_FGFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000007">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000016">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000020">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000011">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016248">
        <property type="entry name" value="FGF_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF505">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000628">
        <property type="entry name" value="FGFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="11 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14 20" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="91"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="193"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="388"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="394"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22 24">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="472"/>
            <end position="474"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="116"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="215"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="728" mass="81240" checksum="34DE749F09477FC5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7D7</accession>
    <name>A0A5F8H7D7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Voltage-dependent L-type calcium channel subunit beta-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Calcium channel voltage-dependent subunit beta 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CACNB2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current. Plays a role in shifting voltage dependencies of activation and inactivation of the channel. May modulate G protein inhibition. May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2. Interacts with CACNA1C. Interacts with RRAD; interaction may be involved in beta-adrenergic regulation of heart rate and contractile force. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane. Interacts with TMIGD2. Interacts with CAMK2D. Interacts with CBARP. Interacts with CAMK2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcium channel beta subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007504969.1">
        <property type="nucleotide sequence ID" value="XM_007504907.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7D7"/>
    <dbReference type="Ensembl" id="ENSMODT00000069415.1">
        <property type="protein sequence ID" value="ENSMODP00000055707.1"/>
        <property type="gene ID" value="ENSMODG00000009618.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100020184"/>
    <dbReference type="CTD" id="783"/>
    <dbReference type="GeneTree" id="ENSGT00950000182837"/>
    <dbReference type="OrthoDB" id="5962384at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009618">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12040">
        <property type="entry name" value="SH3_CACNB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000015">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000023">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046937">
        <property type="entry name" value="CAB1-4_N_A-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035605">
        <property type="entry name" value="CACNB2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005444">
        <property type="entry name" value="VDCC_L_b2su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12052">
        <property type="entry name" value="VGCC_beta4Aa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01628">
        <property type="entry name" value="LCACHANNELB2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="8" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="SH3" evidence="20">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="136"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="432"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="505"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="606" mass="68163" checksum="53C202659FC43BFD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7E3</accession>
    <name>A0A5F8H7E3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrosin like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FBRSL1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7E3"/>
    <dbReference type="Ensembl" id="ENSMODT00000053834.1">
        <property type="protein sequence ID" value="ENSMODP00000055868.1"/>
        <property type="gene ID" value="ENSMODG00000015281.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160709"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015281">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023246">
        <property type="entry name" value="AUTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429">
        <property type="entry name" value="FIBROSIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429:SF20">
        <property type="entry name" value="FIBROSIN-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15336">
        <property type="entry name" value="Auts2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02044">
        <property type="entry name" value="FIBROSIN1LPF"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="741"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="668"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="789" mass="86381" checksum="09D3C23738343B93" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7E4</accession>
    <name>A0A5F8H7E4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">6-phosphofructokinase type B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphofructo-1-kinase isozyme B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PFKL</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7E4"/>
    <dbReference type="Ensembl" id="ENSMODT00000055369.1">
        <property type="protein sequence ID" value="ENSMODP00000055464.1"/>
        <property type="gene ID" value="ENSMODG00000003119.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159292"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003119">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000001">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000003">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF14">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="20">
        <location>
            <begin position="116"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="20">
        <location>
            <begin position="355"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="722" mass="78452" checksum="260BEB50D959B6B8" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7E5</accession>
    <name>A0A5F8H7E5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoenolpyruvate carboxykinase (GTP)</fullName>
            <ecNumber evidence="5">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PCK2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7E5"/>
    <dbReference type="Ensembl" id="ENSMODT00000078517.1">
        <property type="protein sequence ID" value="ENSMODP00000055905.1"/>
        <property type="gene ID" value="ENSMODG00000003599.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001912"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003599">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000006">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF11">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="13">
        <location>
            <begin position="46"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="12">
        <location>
            <begin position="278"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="426" mass="46369" checksum="A6904B55A3AD5FBB" modified="2019-12-11" version="1">MASLYRPCLRLGWHGLCPWGYAPSRANHTLRVISGDLGQLPAKVRDFVERSARLCQPEGIHICDGSEAENDATLALLEREGLVRKLSKYDNCWLARTDPKDVARVESKTVIVTESQRETVPIPADGATGQLGNWMSPAQFQKAIDERFPGCMRGRTMYVLPFSMGPVGSPLSRVGIQLTDSPYVVASMRIMTRLGKPVLQALGDNDFVKCLHSVGRPLPLEGELVNQWPCNPEKTLIGHVPDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITNPAGKKRYVAAAFPSACGKTNLAMMRPTLPGWKVECVGDDIAWMKFDSDGRLRAINPENGFFGVAPGTSATTNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQTLPPGVTVTSWLGKAWKSGKDKFLLLGTLSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7E6</accession>
    <name>A0A5F8H7E6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RNA-binding protein 33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Proline-rich protein 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RNA-binding motif protein 33</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">RBM33</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation. Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5. Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Associates with the NXF1-NXT1 RNA export complex. Interacts with ALKBH5; facilitating ALKBH5 recruitment to m6A-containing transcripts. Interacts with SENP1; promoting ALKBH5 deSUMOylation and subsequent activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7E6"/>
    <dbReference type="Ensembl" id="ENSMODT00000064962.1">
        <property type="protein sequence ID" value="ENSMODP00000055151.1"/>
        <property type="gene ID" value="ENSMODG00000005006.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063891"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005006">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000245">
        <property type="entry name" value="RNA-binding protein 33 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039878">
        <property type="entry name" value="RBM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22014">
        <property type="entry name" value="RNA-BINDING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22014:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="1129"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="186"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="298"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="465"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="828"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="927"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="654"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="760"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="928"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1200" mass="135343" checksum="290863C7806A7761" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7F0</accession>
    <name>A0A5F8H7F0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-lactoglobulin-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7F0"/>
    <dbReference type="FunCoup" id="A0A5F8H7F0">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055722"/>
    <dbReference type="Ensembl" id="ENSMODT00000075166.1">
        <property type="protein sequence ID" value="ENSMODP00000055722.1"/>
        <property type="gene ID" value="ENSMODG00000038687.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:103096593"/>
    <dbReference type="GeneTree" id="ENSGT00950000186241"/>
    <dbReference type="InParanoid" id="A0A5F8H7F0"/>
    <dbReference type="OMA" id="NYMAVNE"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000038687">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002345">
        <property type="entry name" value="Lipocalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430:SF117">
        <property type="entry name" value="GLYCODELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0494">Milk protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023822990" evidence="6">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="7">
        <location>
            <begin position="34"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="203" mass="23532" checksum="15EE4F762A9C548D" modified="2019-12-11" version="1">MKFFLLTVGLALIGTIQAIEHIYPQKDVVVEKLSGGWYLRQLVSTMDFPRNLLLIDIKEVDITPQGDLELVIARRTENCVEKKILVKKTEKPAVFEIDVPSEHDLHTLTMVKTDYDNFTLVCLNMDSLEKKACAYFVRRIDEQKGMEEFKKILLTFPMPYTVTDFLPEGKAEEANPLQDHLSPWQNLWQLFEITTILKMKDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7F1</accession>
    <name>A0A5F8H7F1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ACP7</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7F1"/>
    <dbReference type="FunCoup" id="A0A5F8H7F1">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055156"/>
    <dbReference type="Ensembl" id="ENSMODT00000055877.1">
        <property type="protein sequence ID" value="ENSMODP00000055156.1"/>
        <property type="gene ID" value="ENSMODG00000013442.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015485"/>
    <dbReference type="InParanoid" id="A0A5F8H7F1"/>
    <dbReference type="OMA" id="CKDVFEP"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013442">
        <property type="expression patterns" value="Expressed in cerebellum and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023974276" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="133"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="360"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="439" mass="49851" checksum="BCF39814A19971CD" modified="2019-12-11" version="1">MAGLSPSCYCLLFLFLLGNAGAESLEKATPEQIHLSYPGEPGCMTVTWTTWVPAASEVQFGMQAGGTLALQAQGTSSLFVDGGILKRKLYMHRVTLRRLLPGAHYVYRCGSAQGWSRRFRFRMLQPGPNWSPRLAVFGDMGADNPQALPRLRRETQQGMYDVVLHVGDFAYNMDQDNARVGDTFMRLIEPVAASVPYMTCPGNHEERYNFSNYRARFSMPGDTEGLWYSWDLGPAHIISFSTEVYFFLHYGRHLIQKQFCWLERDLQKANENRASRPWIITMGHRPMYCSNADLDDCTRHESIVRKGLSGGRYGLEDLFYKYGVDLQLWAHEHSYERLWPIYDYQVYNGSRESPYTNPRGPIHIITGSAGCEEMLTPFAPFPRPWSALRVKEYGFTRLHILNGTHLHLQQVSDDQVSSREGGLGLGSGPVPWELGSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7F2</accession>
    <name>A0A5F8H7F2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7F2"/>
    <dbReference type="Ensembl" id="ENSMODT00000079702.1">
        <property type="protein sequence ID" value="ENSMODP00000055910.1"/>
        <property type="gene ID" value="ENSMODG00000023255.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015137"/>
    <dbReference type="OMA" id="KWKQWTS"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023255">
        <property type="expression patterns" value="Expressed in spermatid and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="269" mass="30523" checksum="8FAED4D00BB04C4C" modified="2019-12-11" version="1">MDDSTLGFHDVVPGGTLSMYIWPQDGWKELVFAAVEGDTSKLSCLGVTEDSLYRTPHSLLLKAKKLKEWIDDRAFVALYITAHRGHSEALRFLLANGTNCQGRTPLGRTALHAAAATGQITTINLLLDYGALLSDKDFKGETVAEIARRLKSKEVELNFLKELMSEKKLVFHSDICSAAELIWKGQYIVLSLILKVLNSNVYLGRILKFNPRFPQKTEKMTKQWKNYNERQLSLKQNLRGYLTLHSPSLSTFLQMKKLRLQKVKKLNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7F7</accession>
    <name>A0A5F8H7F7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Atrophin-1-interacting protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Membrane-associated guanylate kinase inverted 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">MAGI2</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Cilium</location>
            <location evidence="4">Photoreceptor outer segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Photoreceptor inner segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Synapse</location>
            <location evidence="19">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7F7"/>
    <dbReference type="Ensembl" id="ENSMODT00000065507.1">
        <property type="protein sequence ID" value="ENSMODP00000055161.1"/>
        <property type="gene ID" value="ENSMODG00000017143.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155057"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017143">
        <property type="expression patterns" value="Expressed in testis and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06731">
        <property type="entry name" value="PDZ1_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06732">
        <property type="entry name" value="PDZ2_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06733">
        <property type="entry name" value="PDZ3_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06734">
        <property type="entry name" value="PDZ4_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06735">
        <property type="entry name" value="PDZ5_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000005">
        <property type="entry name" value="Membrane associated guanylate kinase, WW and PDZ domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000006">
        <property type="entry name" value="Membrane associated guanylate kinase, WW and PDZ domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000113">
        <property type="entry name" value="Membrane associated guanylate kinase, WW and PDZ domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000144">
        <property type="entry name" value="Membrane associated guanylate kinase, WW and PDZ domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000150">
        <property type="entry name" value="Membrane associated guanylate kinase, WW and PDZ domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000001">
        <property type="entry name" value="Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000002">
        <property type="entry name" value="Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316">
        <property type="entry name" value="MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316:SF27">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16663">
        <property type="entry name" value="MAGI_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0770">Synapse</keyword>
    <keyword evidence="11" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="WW" evidence="24">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="24">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="263"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="441"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="600"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="742"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="977"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="535"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="688"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="835"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="835"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="867"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="890"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00080410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1113" mass="123187" checksum="C777C9D625387D74" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F6TI85</accession>
    <name>F6TI85_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BICD cargo adaptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BICD1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007502605.1">
        <property type="nucleotide sequence ID" value="XM_007502543.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6TI85"/>
    <dbReference type="Ensembl" id="ENSMODT00000016204.4">
        <property type="protein sequence ID" value="ENSMODP00000015911.3"/>
        <property type="gene ID" value="ENSMODG00000012717.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100026477"/>
    <dbReference type="CTD" id="636"/>
    <dbReference type="eggNOG" id="KOG0999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154471"/>
    <dbReference type="HOGENOM" id="CLU_014107_1_0_1"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012717">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018477">
        <property type="entry name" value="BICD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233">
        <property type="entry name" value="BICAUDAL D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233:SF3">
        <property type="entry name" value="PROTEIN BICAUDAL D HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09730">
        <property type="entry name" value="BicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="550"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="805"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="111"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="324"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="425"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="672"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000015911.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="840" mass="96474" checksum="0DD5B30DB5041CBC" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F6UKZ2</accession>
    <name>F6UKZ2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Estrogen-induced osteoclastosis regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EEIG1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EEIG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056668447.1">
        <property type="nucleotide sequence ID" value="XM_056812469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6UKZ2"/>
    <dbReference type="FunCoup" id="F6UKZ2">
        <property type="interactions" value="1427"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000007050"/>
    <dbReference type="Ensembl" id="ENSMODT00000007191.4">
        <property type="protein sequence ID" value="ENSMODP00000007050.3"/>
        <property type="gene ID" value="ENSMODG00000005688.4"/>
    </dbReference>
    <dbReference type="GeneID" id="130456458"/>
    <dbReference type="CTD" id="399665"/>
    <dbReference type="eggNOG" id="ENOG502QRRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156811"/>
    <dbReference type="HOGENOM" id="CLU_024948_1_1_1"/>
    <dbReference type="InParanoid" id="F6UKZ2"/>
    <dbReference type="OMA" id="RPPVKQN"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005688">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045672">
        <property type="term" value="P:positive regulation of osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF2">
        <property type="entry name" value="EARLY ESTROGEN-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000007050.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="380" mass="41681" checksum="B721BA6475B59F79" modified="2013-01-09" version="2">MAFLMKKKKFKFQTTFTLEELTAVPFVNGVLFCKIRLLDGGDFASLSSREEVQENCVRWRKKFTFVCKMSANPATGLLDPCICRVSVRKELKGGKAYSKLGFADLNLAEFAGSGSTVRCCLLEGYDTKNTRQDNSILKVTIGMSLLSGDPCFKTPPSTAKSIIIPSQDTSLQLTCKGEGTCSSGSTTLTGTRQSKARPTILGSGVPEEPDQNLSSPEEVFHSGHSRNSSYASQQSKISGYSTEHSRSSSLSDLTHRRNTSTSSSASGGLSMTVECPEGEREHKPEKPPRPPRPLHLSDRSFRRKKDSVESHPTWVDDTRIDADDIVEKIMQSQDFTDVSNNEDSNLRLFVSRDGTTTLSGIQLANRVSSGVFEPVVIESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>F6UL47</accession>
    <name>F6UL47_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Thyroid hormone receptor interactor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TRIP6</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zyxin/ajuba family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016286344.1">
        <property type="nucleotide sequence ID" value="XM_016430858.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6UL47"/>
    <dbReference type="Ensembl" id="ENSMODT00000006079.4">
        <property type="protein sequence ID" value="ENSMODP00000005955.3"/>
        <property type="gene ID" value="ENSMODG00000004834.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100018084"/>
    <dbReference type="KEGG" id="mdo:100018084"/>
    <dbReference type="CTD" id="7205"/>
    <dbReference type="eggNOG" id="KOG1701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154273"/>
    <dbReference type="HOGENOM" id="CLU_001357_10_1_1"/>
    <dbReference type="OrthoDB" id="25414at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004834">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09350">
        <property type="entry name" value="LIM1_TRIP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09357">
        <property type="entry name" value="LIM3_Zyxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000027">
        <property type="entry name" value="lipoma-preferred partner isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000042">
        <property type="entry name" value="lipoma-preferred partner isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000047">
        <property type="entry name" value="lipoma-preferred partner isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24212:SF7">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24212">
        <property type="entry name" value="ZYXIN/TRIP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0440">LIM domain</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="264"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="387"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="173"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000005955.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="463" mass="49598" checksum="1857733A003AC844" modified="2013-01-09" version="2">MSGPTWLPPKQLEAVRLPQGKVLLRGSPGPSTHGTEQSYQAPGRQEERGAVQGRCPGASQSIQGLRPDRGAMHLGSLDAEIDSLTSMLADLDSSRGHAPCRPDRQAYDPLRPPPNRMNHLKPGGGVNPPPRVPVPSYGGPTPASYTTASTPVGPAFPVQVKVAQPVRGYGQSWRGVPQASSPPSAPYLPSTSWTESWGGSYGSHRELGAKEESVGASGPRGGRRTGGYIPKAAPGRAPPEEELERLTKKLVHDMNHPPSGEYFGRCGGCGEDVVGDGAGVIALDRVFHVGCFVCSTCRAQLRGQHFYAVERKAYCEGCYVATLEKCSMCSQPILDRILRAMGKAYHPGCFTCVVCHQGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKSCSAWRIQELSATVTTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>F6YXB0</accession>
    <name>F6YXB0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F-actin cross-linking protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ACTN2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001368653.1">
        <property type="nucleotide sequence ID" value="XM_001368616.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6YXB0"/>
    <dbReference type="STRING" id="13616.ENSMODP00000009304"/>
    <dbReference type="Ensembl" id="ENSMODT00000009485.4">
        <property type="protein sequence ID" value="ENSMODP00000009304.4"/>
        <property type="gene ID" value="ENSMODG00000007497.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100020948"/>
    <dbReference type="KEGG" id="mdo:100020948"/>
    <dbReference type="CTD" id="88"/>
    <dbReference type="eggNOG" id="KOG0035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153968"/>
    <dbReference type="HOGENOM" id="CLU_005217_1_1_1"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007497">
        <property type="expression patterns" value="Expressed in heart and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099103">
        <property type="term" value="F:channel activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051373">
        <property type="term" value="F:FATZ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030274">
        <property type="term" value="F:LIM domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031432">
        <property type="term" value="F:titin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070080">
        <property type="term" value="F:titin Z domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051695">
        <property type="term" value="P:actin filament uncapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055013">
        <property type="term" value="P:cardiac muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048041">
        <property type="term" value="P:focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030035">
        <property type="term" value="P:microspike assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043267">
        <property type="term" value="P:negative regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000009">
        <property type="term" value="P:negative regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086097">
        <property type="term" value="P:phospholipase C-activating angiotensin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001137">
        <property type="term" value="P:positive regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043268">
        <property type="term" value="P:positive regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21214">
        <property type="entry name" value="CH_ACTN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000005">
        <property type="entry name" value="Actinin alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000018">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000002">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000003">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="38"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="151"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="753"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="789"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="437"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="671"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000009304.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="894" mass="103720" checksum="657F62EDE497EDE7" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F6YXG1</accession>
    <name>F6YXG1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bridging integrator 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BIN3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in cytokinesis and septation where it has a role in the localization of F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007476546.1">
        <property type="nucleotide sequence ID" value="XM_007476484.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6YXG1"/>
    <dbReference type="FunCoup" id="F6YXG1">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000011615"/>
    <dbReference type="Ensembl" id="ENSMODT00000011835.2">
        <property type="protein sequence ID" value="ENSMODP00000011615.2"/>
        <property type="gene ID" value="ENSMODG00000009297.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100033114"/>
    <dbReference type="KEGG" id="mdo:100033114"/>
    <dbReference type="CTD" id="55909"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182882"/>
    <dbReference type="HOGENOM" id="CLU_090113_1_0_1"/>
    <dbReference type="InParanoid" id="F6YXG1"/>
    <dbReference type="OMA" id="TRFCAYF"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009297">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014839">
        <property type="term" value="P:myoblast migration involved in skeletal muscle regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009826">
        <property type="term" value="P:unidimensional cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07590">
        <property type="entry name" value="BAR_Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000028">
        <property type="entry name" value="Bridging integrator 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037428">
        <property type="entry name" value="Bin3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="BAR" evidence="11">
        <location>
            <begin position="9"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011615.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="253" mass="29746" checksum="880896EF915DDDA0" modified="2019-12-11" version="2">MSWIPFKIGQPKKQIVPKTVERDFEREYGKLQQLEDQTKKLQKDLKKSTDADLAMSKSAVKISSDLLSNPLCEQDQEFLNLVTALDTAMKRMDAFNQEKVNQIQKTVIEPLKKFGSVFPSLNMAVKRREQALQDYKRLQSKVEKYEEKEKTGPVLAKLHQVREELRPVKDDFEAKNRQLLEEMPRFYNSRLDYFQPSFESLIRAQVVYYTEMHKIFRDLTQQLDQPGHTDEQREQENETKLSELRALSIVADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>F6YXG9</accession>
    <name>F6YXG9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">IKAROS family zinc finger 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IKZF1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Ikaros C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007500468.1">
        <property type="nucleotide sequence ID" value="XM_007500406.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6YXG9"/>
    <dbReference type="Ensembl" id="ENSMODT00000011833.4">
        <property type="protein sequence ID" value="ENSMODP00000011613.3"/>
        <property type="gene ID" value="ENSMODG00000009274.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100030039"/>
    <dbReference type="CTD" id="10320"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156782"/>
    <dbReference type="HOGENOM" id="CLU_025502_2_0_1"/>
    <dbReference type="OrthoDB" id="6417347at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009274">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030098">
        <property type="term" value="P:lymphocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000073">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000265">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000525">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000080">
        <property type="entry name" value="IKAROS family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000168">
        <property type="entry name" value="zinc finger protein Eos isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF36">
        <property type="entry name" value="DNA-BINDING PROTEIN IKAROS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011613.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="574" mass="63633" checksum="46045E1C9B4F74A6" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>F6YXM8</accession>
    <name>F6YXM8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ring finger protein 215</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000011824.3">
        <property type="protein sequence ID" value="ENSMODP00000011604.3"/>
        <property type="gene ID" value="ENSMODG00000009289.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159671"/>
    <dbReference type="HOGENOM" id="CLU_049329_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009289">
        <property type="expression patterns" value="Expressed in lung and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000031">
        <property type="entry name" value="RING finger protein 215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051073">
        <property type="entry name" value="ZNRF3_Arkadia_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16200">
        <property type="entry name" value="RING ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023868593" description="Ring finger protein 215" evidence="3">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011604.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="28617" checksum="4C2049455F4E88F8" modified="2019-12-11" version="2">MKRALVLGASALLILALNQNAVHELDVSQVLSKPIIVVQMSDNVTKLLSALLGGLQATAKITSQAMLLENVGLTLTLWSTCGLSRGGLYGEWQGVICPGESSSRVQKCLQKLWNTILLVALLLCLGLIIQARRQALQGPPEPDPQLDLRQHISRTLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTCAICLDSFTKIRWHPRVCTRRAAPLLSRPQFAPVAPGREGVGAAQTPGSSPARPSLLSSVCGCCPASTNFTANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F6Z9H3</accession>
    <name>F6Z9H3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 6 open reading frame, human C9orf24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SPMIP6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007498932.1">
        <property type="nucleotide sequence ID" value="XM_007498870.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6Z9H3"/>
    <dbReference type="Ensembl" id="ENSMODT00000010218.4">
        <property type="protein sequence ID" value="ENSMODP00000010026.3"/>
        <property type="gene ID" value="ENSMODG00000008058.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100028954"/>
    <dbReference type="KEGG" id="mdo:100028954"/>
    <dbReference type="CTD" id="84688"/>
    <dbReference type="eggNOG" id="ENOG502QRFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000945"/>
    <dbReference type="HOGENOM" id="CLU_093197_0_0_1"/>
    <dbReference type="OMA" id="QTMERHV"/>
    <dbReference type="OrthoDB" id="9820464at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008058">
        <property type="expression patterns" value="Expressed in spermatid and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028195">
        <property type="entry name" value="SPMIP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35664">
        <property type="entry name" value="SPERMATID-SPECIFIC MANCHETTE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35664:SF1">
        <property type="entry name" value="SPERMATID-SPECIFIC MANCHETTE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15181">
        <property type="entry name" value="SMRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000010026.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="254" mass="29320" checksum="3920DDB30E291C9B" modified="2013-01-09" version="2">MFLFAHKTKTPISTYTDSYRAPASIKQDYKDPPLWAWEENKFVSPGLKKPMLEQHVDQQSLEKMVKRAVEEYSYKGSVPGNPYLPQKYWISEAEAERYNPAFISGDRYGAWRTGPYNSSGWNKYTTYLPRLPKEAGMETMMRGMPLDYPPKPDRFNNYEREVVVNMLNSLSRNQLPSIQPRYTVPGRLPFQGYDSPCTGRHYCLRGMDYYATGAPSNERHLTQPTECPPLQPQTRNELCCLIPPPAITLSLYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F6Z9M5</accession>
    <name>F6Z9M5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Helicase POLQ-like</fullName>
            <ecNumber evidence="15">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Mus308-like helicase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">POLQ-like helicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">HELQ</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair. Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA). Possesses both DNA unwinding and annealing activities. Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA. Efficiently unwinds substrates containing 3' overhangs or a D-loop. In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing. Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="15"/>
    <dbReference type="RefSeq" id="XP_001371040.1">
        <property type="nucleotide sequence ID" value="XM_001371003.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6Z9M5"/>
    <dbReference type="Ensembl" id="ENSMODT00000026450.4">
        <property type="protein sequence ID" value="ENSMODP00000025985.4"/>
        <property type="gene ID" value="ENSMODG00000020774.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100017500"/>
    <dbReference type="KEGG" id="mdo:100017500"/>
    <dbReference type="CTD" id="113510"/>
    <dbReference type="eggNOG" id="KOG0950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157350"/>
    <dbReference type="HOGENOM" id="CLU_006553_1_0_1"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020774">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000002">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001293">
        <property type="entry name" value="helicase POLQ-like isoform X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000058">
        <property type="entry name" value="Helicase, POLQ like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="302"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="522"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000025985.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1061" mass="119901" checksum="F8C8DEB84A3DF29F" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F7AKU1</accession>
    <name>F7AKU1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PITRM1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. It is also able to degrade amyloid-beta protein 42.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7AKU1"/>
    <dbReference type="STRING" id="13616.ENSMODP00000008176"/>
    <dbReference type="Ensembl" id="ENSMODT00000008341.4">
        <property type="protein sequence ID" value="ENSMODP00000008176.3"/>
        <property type="gene ID" value="ENSMODG00000006591.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018381"/>
    <dbReference type="HOGENOM" id="CLU_009165_0_0_1"/>
    <dbReference type="OMA" id="NYLYYIR"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006591">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000020">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="16">
        <location>
            <begin position="498"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000008176.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1027" mass="117124" checksum="19BAEEABD243781B" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F7AKZ0</accession>
    <name>F7AKZ0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ATE1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="RefSeq" id="XP_007478952.1">
        <property type="nucleotide sequence ID" value="XM_007478890.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7AKZ0"/>
    <dbReference type="Ensembl" id="ENSMODT00000010694.3">
        <property type="protein sequence ID" value="ENSMODP00000010488.1"/>
        <property type="gene ID" value="ENSMODG00000008434.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100025687"/>
    <dbReference type="CTD" id="11101"/>
    <dbReference type="eggNOG" id="KOG1193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044926"/>
    <dbReference type="HOGENOM" id="CLU_020349_1_1_1"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008434">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="294"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000010488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="522" mass="60185" checksum="B99A9D33B3F37E12" modified="2011-07-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>F7C0C6</accession>
    <name>F7C0C6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPRY domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F7C0C6"/>
    <dbReference type="Ensembl" id="ENSMODT00000013775.3">
        <property type="protein sequence ID" value="ENSMODP00000013528.3"/>
        <property type="gene ID" value="ENSMODG00000010799.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011048"/>
    <dbReference type="HOGENOM" id="CLU_085855_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010799">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd12880">
        <property type="entry name" value="SPRYD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035766">
        <property type="entry name" value="SPRYD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951">
        <property type="entry name" value="C13ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951:SF2">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000013528.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="190" mass="20850" checksum="52BC360A7A35BC6A" modified="2019-12-11" version="2">MAASVFCCLRCCGDSGSGHIQLKEMPAVQLDTQHMGTDVVIVKNGRRICGTGGCLANAPLHQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDVHSLVMRNDGALYHNNEEKNRLPANNLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSDFYHIPPTGFEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>F7CQZ9</accession>
    <name>F7CQZ9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 8 open reading frame 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C8orf34</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F7CQZ9"/>
    <dbReference type="Ensembl" id="ENSMODT00000009467.4">
        <property type="protein sequence ID" value="ENSMODP00000009286.3"/>
        <property type="gene ID" value="ENSMODG00000007483.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUHG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005870"/>
    <dbReference type="HOGENOM" id="CLU_030572_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007483">
        <property type="expression patterns" value="Expressed in spinal cord and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd22980">
        <property type="entry name" value="DD_VEST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040687">
        <property type="entry name" value="DUF5586"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32000:SF3">
        <property type="entry name" value="RIKEN CDNA A830018L16 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32000">
        <property type="entry name" value="SIMILAR TO HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17824">
        <property type="entry name" value="DUF5586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000009286.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="319" mass="36056" checksum="53A895C4A5B7C937" modified="2019-12-11" version="2">MASHQQTRIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQSKQGPRSQLQRTLSGSAALWAESETSEPKGTRRDFRSYDKPWQVNAKKPKKSKSDLAVSNISPPSPESKSLPRSVEHPKWNWRIKPESHDFDELNHILQESKKLGKALENLSRSIAISDELDKDTMAFNSTLLRPRVIGEWVGREENDADPLAAEMLQPPIPRSKNEQWGSEDSTTSPAGSLKMEPKSKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLDDLRMEGVTTLITLLTDTYDTESEGIEAEQDKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>F7CRA2</accession>
    <name>F7CRA2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Meprin A subunit</fullName>
            <ecNumber evidence="22">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Endopeptidase-2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="34 35">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of 5-His-|-Leu-6, 6-Leu-|-Cys-7, 14-Ala-|-Leu-15 and 19-Cys-|-Gly-20 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.63"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="26 27">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="26 27">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homotetramer consisting of disulfide-linked beta subunits, or heterotetramer of two alpha and two beta subunits formed by non-covalent association of two disulfide-linked heterodimers. Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity. Interacts with TSPAN8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="22"/>
    <dbReference type="AlphaFoldDB" id="F7CRA2"/>
    <dbReference type="MEROPS" id="M12.002"/>
    <dbReference type="Ensembl" id="ENSMODT00000023978.3">
        <property type="protein sequence ID" value="ENSMODP00000023560.3"/>
        <property type="gene ID" value="ENSMODG00000018884.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183111"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018884">
        <property type="expression patterns" value="Expressed in spermatid and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7CRA2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000363">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000037">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000009">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008294">
        <property type="entry name" value="Meprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF824">
        <property type="entry name" value="MEPRIN A SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001196">
        <property type="entry name" value="Meprin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00740">
        <property type="entry name" value="MAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 25" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 22 26" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="15 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 22 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 22 26" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 22 26" id="KW-0645">Protease</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12 22 24" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="33">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="31">
        <location>
            <begin position="187"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="32">
        <location>
            <begin position="352"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="30">
        <location>
            <begin position="592"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="542"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="active site" evidence="23 26">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24 26">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 26">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 26">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR001196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR001196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR001196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000023560.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="669" mass="76349" checksum="C65F5743AE904135" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>F7CRA8</accession>
    <name>F7CRA8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Potassium voltage-gated channel interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KCNIP2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001369622.2">
        <property type="nucleotide sequence ID" value="XM_001369585.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7CRA8"/>
    <dbReference type="Ensembl" id="ENSMODT00000037125.3">
        <property type="protein sequence ID" value="ENSMODP00000035539.2"/>
        <property type="gene ID" value="ENSMODG00000011638.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100023320"/>
    <dbReference type="CTD" id="30819"/>
    <dbReference type="eggNOG" id="KOG0044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157798"/>
    <dbReference type="HOGENOM" id="CLU_072366_2_2_1"/>
    <dbReference type="OMA" id="CQQRCKK"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011638">
        <property type="expression patterns" value="Expressed in heart and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000043">
        <property type="entry name" value="Kv channel-interacting protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF65">
        <property type="entry name" value="KV CHANNEL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000035539.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="235" mass="27130" checksum="F57350C4C4B59485" modified="2013-01-09" version="2">MGCVRGSNRSMSWCPRSCRSPLGHAARSLFQFVTGTLAPDSVEDEFELSTVCHRPEGLEQLQEQTKFTRKELQVLYRGFKNECPSGIVNEENFKQIYSQFFPQGDSSTYATFLFNAFDTNHDGSVSFEDFVAGLSVILRGTIDDRLNWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYPALREEAPREHVENFFQKMDRNKDGVVTIEEFIESCQKDENIMRSMQLFDDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>F7D3A1</accession>
    <name>F7D3A1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">JAG2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001368393.2">
        <property type="nucleotide sequence ID" value="XM_001368356.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7D3A1"/>
    <dbReference type="FunCoup" id="F7D3A1">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000018384"/>
    <dbReference type="Ensembl" id="ENSMODT00000018717.4">
        <property type="protein sequence ID" value="ENSMODP00000018384.3"/>
        <property type="gene ID" value="ENSMODG00000014707.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100014054"/>
    <dbReference type="KEGG" id="mdo:100014054"/>
    <dbReference type="CTD" id="3714"/>
    <dbReference type="eggNOG" id="KOG1217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160944"/>
    <dbReference type="HOGENOM" id="CLU_004732_0_0_1"/>
    <dbReference type="InParanoid" id="F7D3A1"/>
    <dbReference type="OMA" id="GSWVEDC"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014707">
        <property type="expression patterns" value="Expressed in lung and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055123">
        <property type="term" value="P:digestive system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048732">
        <property type="term" value="P:gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045061">
        <property type="term" value="P:thymic T cell selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035239">
        <property type="term" value="P:tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000018">
        <property type="entry name" value="Delta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000061">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000148">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000310">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000431">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000445">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000473">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000824">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3510:FF:000006">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000146">
        <property type="entry name" value="Putative neurogenic locus notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056986">
        <property type="entry name" value="JAG1_1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026219">
        <property type="entry name" value="Jagged/Serrate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF12">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23575">
        <property type="entry name" value="JAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02059">
        <property type="entry name" value="JAGGEDFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 16" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12 14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 14 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003355865" description="Delta-like protein" evidence="19">
        <location>
            <begin position="25"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1084"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="21">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="307"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="423"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="461"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="536"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="585"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="636"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="674"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="712"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="751"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="789"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="827"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1167"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1167"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1188"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000018384.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1247" mass="137857" checksum="81BDCDE466669078" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>F7E6D6</accession>
    <name>F7E6D6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="18">PPIase</shortName>
            <ecNumber evidence="18">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">AQP7</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="18"/>
    <dbReference type="RefSeq" id="XP_007497966.1">
        <property type="nucleotide sequence ID" value="XM_007497904.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7E6D6"/>
    <dbReference type="Ensembl" id="ENSMODT00000039413.2">
        <property type="protein sequence ID" value="ENSMODP00000037808.2"/>
        <property type="gene ID" value="ENSMODG00000025351.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100011004"/>
    <dbReference type="CTD" id="364"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156008"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025351">
        <property type="expression patterns" value="Expressed in heart and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7E6D6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000011">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF490">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 18" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="20">
        <location>
            <begin position="125"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000037808.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="283" mass="31342" checksum="1859FC9510D67CD6" modified="2019-12-11" version="2">MNTGYPINPARDLPPRIFTSIAGWGNEVFTAGESWWWVPVVAPPLGALMGGITYLIFVGPSNRPQQRSVEHILPKPRVLQPMKQKEHQMPLKALQFKPSIEHLSEAPFRMLTDMSSEAVGNPIVFFDITVDEEPLGRITFELFANTVPRTAENFRALSTGEKGFGYKGSYFHRIIPGFMCQGGDFTNHNGTGGMSIYGDTFPDENFILKHSGPGILSMANSGPNTNSSQFFICTDKTDWLDGKHVVFGQVKTGMNIVEIMESFGSRDGRTSRKVVISNCGQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>F7E6I8</accession>
    <name>F7E6I8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cadherin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CDH4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cell membrane</location>
            <topology evidence="1 15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7E6I8"/>
    <dbReference type="Ensembl" id="ENSMODT00000021182.4">
        <property type="protein sequence ID" value="ENSMODP00000020815.4"/>
        <property type="gene ID" value="ENSMODG00000016675.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158073"/>
    <dbReference type="HOGENOM" id="CLU_005284_2_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016675">
        <property type="expression patterns" value="Expressed in liver and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000011">
        <property type="entry name" value="Cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000019">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000022">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000027">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000045">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000001">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014868">
        <property type="entry name" value="Cadherin_pro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF81">
        <property type="entry name" value="CADHERIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08758">
        <property type="entry name" value="Cadherin_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01820">
        <property type="entry name" value="DESMOCOLLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01055">
        <property type="entry name" value="Cadherin_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 15" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="671"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="119"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="227"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="342"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="457"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="563"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000020815.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="865" mass="95832" checksum="7B7C12B7FDCC351A" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>F7EXB0</accession>
    <name>F7EXB0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RANGAP1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007502634.1">
        <property type="nucleotide sequence ID" value="XM_007502572.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007502636.1">
        <property type="nucleotide sequence ID" value="XM_007502574.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007502637.1">
        <property type="nucleotide sequence ID" value="XM_007502575.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007502638.1">
        <property type="nucleotide sequence ID" value="XM_007502576.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056653398.1">
        <property type="nucleotide sequence ID" value="XM_056797420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7EXB0"/>
    <dbReference type="Ensembl" id="ENSMODT00000016694.5">
        <property type="protein sequence ID" value="ENSMODP00000016392.4"/>
        <property type="gene ID" value="ENSMODG00000013097.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100013673"/>
    <dbReference type="CTD" id="5905"/>
    <dbReference type="eggNOG" id="KOG1909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000039203"/>
    <dbReference type="HOGENOM" id="CLU_028747_2_0_1"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013097">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000142">
        <property type="entry name" value="Ran GTPase activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.200">
        <property type="entry name" value="Ran-GTPase activating protein 1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009109">
        <property type="entry name" value="Ran_GTPase_activating_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036720">
        <property type="entry name" value="RanGAP1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07834">
        <property type="entry name" value="RanGAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69099">
        <property type="entry name" value="Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ran-GTPase activating protein 1 C-terminal" evidence="9">
        <location>
            <begin position="393"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="357"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000016392.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="572" mass="61886" checksum="81CFDEA0CAA303CC" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3U5</accession>
    <name>A0A5F8G3U5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Signal peptide, CUB domain and EGF like domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SCUBE2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3U5"/>
    <dbReference type="Ensembl" id="ENSMODT00000075743.1">
        <property type="protein sequence ID" value="ENSMODP00000042139.1"/>
        <property type="gene ID" value="ENSMODG00000007737.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153185"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007737">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000032">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000002">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000199">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000237">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000256">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000028">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000029">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000030">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000035">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000002">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000008">
        <property type="entry name" value="Signal peptide, CUB domain, EGF-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052071">
        <property type="entry name" value="SCUB_EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046:SF3">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023869018" evidence="11">
        <location>
            <begin position="32"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="793"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="958" mass="105793" checksum="14167D4735185188" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3V0</accession>
    <name>A0A5F8G3V0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coenzyme Q3, methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">COQ3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3V0"/>
    <dbReference type="Ensembl" id="ENSMODT00000064631.1">
        <property type="protein sequence ID" value="ENSMODP00000042116.1"/>
        <property type="gene ID" value="ENSMODG00000018116.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007284"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018116">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="129" mass="14010" checksum="D9E79B0D39967CF7" modified="2019-12-11" version="1">MKILDVGCGGGLLCEPGGSLFITTINKTQLSYALAIIFAEQIAGIVPKGTHTWEKFVSPEQLESFLESNGLLVQTIIGMLYNPFSGYWRWTENTSLNYATHAVKSSVQAENEEHHAKAPGVHGMGASQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3V1</accession>
    <name>A0A5F8G3V1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-binding protein RFX2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Regulatory factor X 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RFX2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene H1-6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer; probably only forms homodimers in testis. Heterodimer; heterodimerizes with RFX1 and RFX3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3V1"/>
    <dbReference type="Ensembl" id="ENSMODT00000053278.1">
        <property type="protein sequence ID" value="ENSMODP00000042095.1"/>
        <property type="gene ID" value="ENSMODG00000001398.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244879"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001398">
        <property type="expression patterns" value="Expressed in ovary and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000017">
        <property type="entry name" value="transcription factor RFX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007668">
        <property type="entry name" value="RFX1_trans_act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF17">
        <property type="entry name" value="DNA-BINDING PROTEIN RFX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04589">
        <property type="entry name" value="RFX1_trans_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="14">
        <location>
            <begin position="176"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="270"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="685" mass="76429" checksum="68A8FB54FD41CC88" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3V3</accession>
    <name>A0A5F8G3V3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">R3H domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">R3HDM1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000052418.1">
        <property type="protein sequence ID" value="ENSMODP00000042149.1"/>
        <property type="gene ID" value="ENSMODG00000000923.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156095"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000923">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000001">
        <property type="entry name" value="R3H domain-containing protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF12">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="155"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="219"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="835"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="995" mass="110442" checksum="97624EFF4CBEC48B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3V4</accession>
    <name>A0A5F8G3V4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="4">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100617706</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39923"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74001"/>
            <dbReference type="ChEBI" id="CHEBI:75216"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:39924"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:75542"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:41120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a sphingosylphosphocholine + H2O = a sphingoid base + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:84410"/>
            <dbReference type="ChEBI" id="CHEBI:85171"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:45297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-(acyl)-sphingosylphosphocholine + H2O = an N-acyl-sphingoid base + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45300"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64583"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:45301"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3V4"/>
    <dbReference type="STRING" id="13616.ENSMODP00000042137"/>
    <dbReference type="Ensembl" id="ENSMODT00000079093.1">
        <property type="protein sequence ID" value="ENSMODP00000042137.1"/>
        <property type="gene ID" value="ENSMODG00000024098.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00400000022168"/>
    <dbReference type="InParanoid" id="A0A5F8G3V4"/>
    <dbReference type="OMA" id="ANICIMP"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000024098">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF9">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="12">
        <location>
            <begin position="184"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="478" mass="51813" checksum="F29E370B7FC1372E" modified="2019-12-11" version="1">MGPGAPPASWSQSLGGFRCSPFPHPALHVLHSLARALLFPAYWALDRLLVCCVPTPFSQGPGHFLGALLGGLASLLLLLAALPLLLLGLLLWLPLQYWRRPFCYQPPPGNWTPPSPWCPPSDPPRSFRFLSANLCLLPDGLARFSNLKHSQHRAEWTGTALLRGARGPGYGATGSSPPRAGSLVGQLVSALPGSVDFVCLQETFDVRASSRLAQRLATTLGPVIYDVGTTGIHPGPQLKLLGSGLLLVSRYPMLNARFLPFPNGRREDALASKGLLSVQVQLGMLDGRRIVGYLHCTHLQAPEEDWAIRCEQLSLLLGWAEQFEAQRDKDTDAVAFSVLMGDLNFDNCSSDDAQEQEHELFTHFRDPCRLGPGQDQPWAIGTLLSAPTLHCPVACCPEKLKSALEQEDGKNMYLAGPPSGDLPSGTWRGRRIDYILYREDPNPLFIPVSAQWSSDKTGNTDLIPDGGGGEGAGHDGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3V5</accession>
    <name>A0A5F8G3V5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Golgin A7 family member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GOLGA7B</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3V5"/>
    <dbReference type="Ensembl" id="ENSMODT00000086165.1">
        <property type="protein sequence ID" value="ENSMODP00000042121.1"/>
        <property type="gene ID" value="ENSMODG00000028192.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000134"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000028192">
        <property type="expression patterns" value="Expressed in cerebellum and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF2">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="4">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="156" mass="17653" checksum="B8C847E9FFD5059A" modified="2019-12-11" version="1">MATEGHNLQELRRSASLATKVFIQRDYSDGTICQFQTKFPPELDSRIERQLFEETVKTLNNFYAEAEKIGGSSYLEGCLACATAYFIFLCMETHYEKVLKKISRYIQEQNEKIFAPRGLLLTDPVERGMRVVSFMIVTDGAGAGLGEQWAGIHISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3V7</accession>
    <name>A0A5F8G3V7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="12">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MRPS34</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the phosphorylation of ribonucleosides and deoxyribonucleoside diphosphates, other than ATP, into the corresponding triphosphates with ATP as the major phosphate donor. The ATP gamma phosphate is transferred to the nucleoside diphosphate beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis. Inhibits granulocyte differentiation. May be required for ciliary function during renal development.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Independently of its kinase activity, facilitates mitochondrial tethering prior to membrane fusion through its direct membrane-binding and hexamerization. Implicated in repair of both single- and double-stranded breaks in DNA through its association with the ribonucleotide reductase complex (RNR complex) via its interaction with the histone acetyltransferase KAT5, this interaction enables recruitment of NME3 at DNA damage sites where it plays a role in the repair of DNA, independently of its kinase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:44641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:18114"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer. Interacts (via its N-terminal region) with KAT5; this interaction enables recruitment of NME3 at DNA damage sites where it plays a role in the repair of DNA. Found in association with several ciliary nephronophthisis proteins, including NEK8, CEP164, ANKS6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3V7"/>
    <dbReference type="FunCoup" id="A0A5F8G3V7">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042154"/>
    <dbReference type="Ensembl" id="ENSMODT00000052720.1">
        <property type="protein sequence ID" value="ENSMODP00000042154.1"/>
        <property type="gene ID" value="ENSMODG00000016134.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161283"/>
    <dbReference type="InParanoid" id="A0A5F8G3V7"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016134">
        <property type="expression patterns" value="Expressed in cerebellum and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032053">
        <property type="entry name" value="Ribosomal_mS34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16053">
        <property type="entry name" value="MRP-S34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="13">
        <location>
            <begin position="127"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="10">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="275" mass="32040" checksum="5726150C3F84A5DC" modified="2019-12-11" version="1">MARKKVRPRLIAELARKIRAYRELKSRPRDSERFALDYETMTRPRTGRRLPERAWADVRNESRLLQLLSRLPLFGLGRLVTRKSWLWQHDEPCYWRLTRVRADYTAPNLDHGKAWGILTFQAWTGLNERTFLAIKPDGFQRRLVGEIIRRFEKKGFKLVGLKLVQASEDLLREHYSALRDRPFYSRLVKYMSSGPVVAMVWQGLDVVRSSRALIGATNPADSAPGTIRGDFCIEVGKNVIHGSDSVDSARREIALWFHADELQCWEDGAERWLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3V8</accession>
    <name>A0A5F8G3V8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CSL-type zinc finger-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DPH3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase. Interacts with SERGEF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3V8"/>
    <dbReference type="Ensembl" id="ENSMODT00000073416.1">
        <property type="protein sequence ID" value="ENSMODP00000042105.1"/>
        <property type="gene ID" value="ENSMODG00000025472.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007225"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025472">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="10">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="57" mass="6651" checksum="E33E03075173C4FB" modified="2019-12-11" version="1">MSVFHDEVEIEDFEYEEETETYFYPCPCGDNFIITKDQFMCGETVSVPPTSKELVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3W0</accession>
    <name>A0A5F8G3W0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Calmodulin-binding transcription activator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CAMTA2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription activator. May act as tumor suppressor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May interact with calmodulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CAMTA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3W0"/>
    <dbReference type="Ensembl" id="ENSMODT00000056026.1">
        <property type="protein sequence ID" value="ENSMODP00000042142.1"/>
        <property type="gene ID" value="ENSMODG00000005219.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160105"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005219">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000004">
        <property type="entry name" value="calmodulin-binding transcription activator 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000015">
        <property type="entry name" value="calmodulin-binding transcription activator 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000089">
        <property type="entry name" value="calmodulin-binding transcription activator 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005559">
        <property type="entry name" value="CG-1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335:SF9">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03859">
        <property type="entry name" value="CG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01076">
        <property type="entry name" value="CG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51437">
        <property type="entry name" value="CG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CG-1" evidence="13">
        <location>
            <begin position="98"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="277"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="441"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="824"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1153"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1217" mass="134067" checksum="69566180829B45FF" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3W1</accession>
    <name>A0A5F8G3W1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0462 protein C4orf33 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC100011172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0462 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3W1"/>
    <dbReference type="Ensembl" id="ENSMODT00000059588.1">
        <property type="protein sequence ID" value="ENSMODP00000042159.1"/>
        <property type="gene ID" value="ENSMODG00000038142.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006284"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000038142">
        <property type="expression patterns" value="Expressed in spermatocyte and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31475">
        <property type="entry name" value="UPF0462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31475:SF6">
        <property type="entry name" value="UPF0462 PROTEIN C4ORF33 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="211" mass="24232" checksum="AD161EF15F36FC67" modified="2019-12-11" version="1">MDWRVERLEARNQEVAMIQLEYDIITTWDSLPVAHRPVTFHFKPGDQGLLMEVSAPFFDDPLAPPGAPGQPFNGLWEYEVVEAFFLNSTTKGYLEVELCPHGQHLVLLLSSGDAFAKELDLNFRADIHGKEWNGTALLPWEYFPPGIDKMNLYAIHGSGDRRTYEALYPIPCEEIAAGQGPNFHRLEYFKPFDLKWVMGDDWEQPHSKLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3W4</accession>
    <name>A0A5F8G3W4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Betaine--homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BHMT</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the regulation of homocysteine metabolism.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3W4"/>
    <dbReference type="Ensembl" id="ENSMODT00000056672.1">
        <property type="protein sequence ID" value="ENSMODP00000042147.1"/>
        <property type="gene ID" value="ENSMODG00000025328.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100019792"/>
    <dbReference type="GeneTree" id="ENSGT00390000003122"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025328">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008172">
        <property type="term" value="F:S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000003">
        <property type="entry name" value="Betaine--homocysteine S-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051524">
        <property type="entry name" value="BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120">
        <property type="entry name" value="BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120:SF3">
        <property type="entry name" value="S-METHYLMETHIONINE--HOMOCYSTEINE S-METHYLTRANSFERASE BHMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="9">
        <location>
            <begin position="11"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="363" mass="39974" checksum="CDF228F53E7FFE96" modified="2019-12-11" version="1">MAPVGGKRAKKGILERLHSGEVVIGDGSFLFTLEKRGYVKAGLWTPEATVEHPEAVRQLHTEYLRAGSNVMQTFTFFAGKDNLESKWKEVNEAACDLAREVAEKGDALVAGGISQTSLYKSHGSEPEIKENFQLQLEVFTRKNVDFLIAEYFEYCEEAVWAVEVLKGSGKPVAATMCIGPEGDMNNLTPGECAVRLVKAGASIVGVNCRFGPEISLATVKLMKEGLEASGLKAYLMVQSLGFHTPDCGKGGFVDLPQYPFGMEPRVATRWDIQKYAREAYKLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPDASEKHGSWGSGLNMHTKPWVRARAQKEYWKNLLPASGRPYFPSLSKPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3W5</accession>
    <name>A0A5F8G3W5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LPIN2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27429"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27430"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3W5"/>
    <dbReference type="Ensembl" id="ENSMODT00000063368.1">
        <property type="protein sequence ID" value="ENSMODP00000042164.1"/>
        <property type="gene ID" value="ENSMODG00000021466.6"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156313"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021466">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF11">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE LPIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="7">
        <location>
            <begin position="619"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="368"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="830" mass="93201" checksum="5BD35C8441BBD9AD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3W7</accession>
    <name>A0A5F8G3W7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Neural cell adhesion molecule 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NCAM1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with MDK. Found in a complex with SLC39A6, SLC39A10 and with NCAM1; this complex controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-tomesenchymal transition. Interacts with synaptic plasticity regulator PANTS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3W7"/>
    <dbReference type="Ensembl" id="ENSMODT00000055798.1">
        <property type="protein sequence ID" value="ENSMODP00000042136.1"/>
        <property type="gene ID" value="ENSMODG00000014314.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155743"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014314">
        <property type="expression patterns" value="Expressed in spinal cord and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05865">
        <property type="entry name" value="IgI_1_NCAM-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000086">
        <property type="entry name" value="Neural cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000173">
        <property type="entry name" value="Neural cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000151">
        <property type="entry name" value="neural cell adhesion molecule 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000137">
        <property type="entry name" value="neural cell adhesion molecule 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000149">
        <property type="entry name" value="neural cell adhesion molecule 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000159">
        <property type="entry name" value="neural cell adhesion molecule 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000221">
        <property type="entry name" value="neural cell adhesion molecule 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009138">
        <property type="entry name" value="Neural_cell_adh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF239">
        <property type="entry name" value="NEURAL CELL ADHESION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01838">
        <property type="entry name" value="NCAMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023852789" description="Neural cell adhesion molecule 1" evidence="16">
        <location>
            <begin position="20"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="116"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="212"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="307"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="405"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="498"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="635"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="597"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="760" mass="83834" checksum="C8A9F8F2DD0B319E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3W8</accession>
    <name>A0A5F8G3W8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MLLT10 histone lysine methyltransferase DOT1L cofactor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MLLT10</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3W8"/>
    <dbReference type="Ensembl" id="ENSMODT00000086796.1">
        <property type="protein sequence ID" value="ENSMODP00000042152.1"/>
        <property type="gene ID" value="ENSMODG00000009138.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157711"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009138">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20901">
        <property type="entry name" value="CC_AF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15708">
        <property type="entry name" value="ePHD_AF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15574">
        <property type="entry name" value="PHD_AF10_AF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000042">
        <property type="entry name" value="protein AF-10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000053">
        <property type="entry name" value="protein AF-10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049773">
        <property type="entry name" value="AF10-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049781">
        <property type="entry name" value="AF10/AF17_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049775">
        <property type="entry name" value="AF10_ePHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF93">
        <property type="entry name" value="PROTEIN AF-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="79"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="134"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="424"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="524"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="728"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="684"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1027" mass="107762" checksum="B65A8BD0DD47DE83" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3W9</accession>
    <name>A0A5F8G3W9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">U6 snRNA-associated Sm-like protein LSm8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">LSM8</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3W9"/>
    <dbReference type="FunCoup" id="A0A5F8G3W9">
        <property type="interactions" value="1721"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042120"/>
    <dbReference type="Ensembl" id="ENSMODT00000056395.1">
        <property type="protein sequence ID" value="ENSMODP00000042120.1"/>
        <property type="gene ID" value="ENSMODG00000015729.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111212"/>
    <dbReference type="InParanoid" id="A0A5F8G3W9"/>
    <dbReference type="OMA" id="AACDQTT"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015729">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000022">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="122" mass="13498" checksum="E3B141E88B1B7C1E" modified="2019-12-11" version="1">MHQLHHLCVHPWKVYSQDSGKQGQRIMTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3X1</accession>
    <name>A0A5F8G3X1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RNA-binding protein 39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RNA-binding motif protein 39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">RBM39</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with NCOA6 and JUN. Interacts with ESR1 and ESR2, in the presence of estradiol (E2). Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with SF3B1. Interacts with ZNF106 (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3X1"/>
    <dbReference type="Ensembl" id="ENSMODT00000072463.1">
        <property type="protein sequence ID" value="ENSMODP00000042141.1"/>
        <property type="gene ID" value="ENSMODG00000001557.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154468"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001557">
        <property type="expression patterns" value="Expressed in ovary and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12537">
        <property type="entry name" value="RRM1_RBM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000080">
        <property type="entry name" value="RNA-binding protein 39 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000090">
        <property type="entry name" value="RNA-binding protein 39 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000373">
        <property type="entry name" value="RNA-binding protein 39 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="123"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="220"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="494" mass="55484" checksum="3673D11787F88C76" modified="2019-12-11" version="1">MFQSSKFFTIHYLMHPYNNFVRRKKSKSRSRSHDRKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRERRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQSEVTALAAAASVQPLATQCFQLSNMFNPQTEDELGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLLVPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3X2</accession>
    <name>A0A5F8G3X2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EvC ciliary complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EVC2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000054795.1">
        <property type="protein sequence ID" value="ENSMODP00000042157.1"/>
        <property type="gene ID" value="ENSMODG00000001716.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154127"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001716">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022076">
        <property type="entry name" value="Limbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026501">
        <property type="entry name" value="Limbin/EVC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16795:SF14">
        <property type="entry name" value="LIMBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16795">
        <property type="entry name" value="LIMBIN/ELLIS-VAN CREVELD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12297">
        <property type="entry name" value="EVC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1354" mass="155636" checksum="34F75C59F39201BD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3X4</accession>
    <name>A0A5F8G3X4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-39kD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase 39 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Interacts with BLOC1S1. Interacts with SLC2A4. Interacts with CLOCK. Interacts with RAB5IF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the complex I NDUFA9 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3X4"/>
    <dbReference type="Ensembl" id="ENSMODT00000073857.1">
        <property type="protein sequence ID" value="ENSMODP00000042174.1"/>
        <property type="gene ID" value="ENSMODG00000018283.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006865"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018283">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000246">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="16">
        <location>
            <begin position="71"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="348" mass="40073" checksum="BE37D5C271779814" modified="2019-12-11" version="1">MRKFLIAISQFTLPNRHQRFPCLCSELCSLIFCSSFQPVSSAFLGRMGSQVIVPYRCEPYDFTYLRPMGDLGQIIFLEWNSKDKSSIQRALEHSNVVINLVGRDWETRNFDFTDVFADIPESIAQLAKEAGVETFIHVSHLNADIKSTSKYLRNKAVGEKAVREAFPEAIILKPADIFGREDRLLNYFANNRWFGGVPLISMGKKTVKQPVYVVDVSRAIVNAIKDPDSRGKTYAITGPNRYLLHDFVQYIFAVSHRPYFPYSMPRFTYQLVAKIFEMSPFEPWTTRDKIERIHISDKKLPHLPGLEDLGVEPTPLELKAIEILRRHRTYRWLSAESEDIKPAKTVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3X9</accession>
    <name>A0A5F8G3X9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC103094333</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3X9"/>
    <dbReference type="Ensembl" id="ENSMODT00000072278.1">
        <property type="protein sequence ID" value="ENSMODP00000042148.1"/>
        <property type="gene ID" value="ENSMODG00000048900.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161954"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000048900">
        <property type="expression patterns" value="Expressed in endometrium and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003698">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000292">
        <property type="entry name" value="zinc finger protein 619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="110"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="496" mass="56697" checksum="371C5E175609B392" modified="2019-12-11" version="1">MKGWGGSAPCAGNIEEGGGRRGPHCKPKRELQEAWRGGGSVSGREHRRRGLWEAGSEGSSSLLLLPFQRCSHFGPFTGRRTPSAPRLEPREPGVPGMALQTDRLPAQEVVTFQDVAVDFTREEWRLLSPPQKELYKEVMLENVRNLLSVGEIRPEMKVNPSEVSLPVEEMDLQRFMSDGLDNFASRKFCVAPQNSSHIEHQRMHTEEKSSERNQCRKTLMHRASLAGHQKIHTGEKPYECKECGKKFRQSSDLAVHQRIHTGDKPYECKQCGKSFSQSSHLARHQRIHTGEKPYECKQCGKAFSQSSCLVLHQRIHTGEKPYECKECGKTFSMSSHLAVHQRIHTGEKPYECKECGKTFRLSSSLAVHQRIHTGEKPYECKQCGKTFSRSYYLAVHQRMHTGEKPYECKQCGKMFSRSSHLVVHQRTHTGERPFECNQCGKTFKERSKLAVHRRTHTGEKPYECKQCGKTFGRSCYLSVHQRIHIGRNLKNTRDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Y1</accession>
    <name>A0A5F8G3Y1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35" type="primary">CACNA1C</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="28">Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.</text>
    </comment>
    <comment type="function">
        <text evidence="31">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="24">Cell membrane</location>
            <location evidence="24">Sarcolemma</location>
            <location evidence="24">T-tubule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="31">Membrane</location>
            <topology evidence="31">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Postsynaptic density membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000086031.1">
        <property type="protein sequence ID" value="ENSMODP00000042167.1"/>
        <property type="gene ID" value="ENSMODG00000018433.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156127"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018433">
        <property type="expression patterns" value="Expressed in heart and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000009">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000021">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000006">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000060">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000062">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000090">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031688">
        <property type="entry name" value="CAC1F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005451">
        <property type="entry name" value="VDCC_L_a1csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005446">
        <property type="entry name" value="VDCC_L_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF10">
        <property type="entry name" value="VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16885">
        <property type="entry name" value="CAC1F_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01630">
        <property type="entry name" value="LVDCCALPHA1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01635">
        <property type="entry name" value="LVDCCALPHA1C"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 29 31" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 31" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="7 31" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0966">Cell projection</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20 30" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="23" id="KW-0407">Ion channel</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 29" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0770">Synapse</keyword>
    <keyword evidence="9 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 33" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="14 31" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="680"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="884"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="926"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="970"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1095"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1172"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1205"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1311"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1405"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-1 subunit IQ" evidence="34">
        <location>
            <begin position="1562"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="717"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1682"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1814"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1892"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="2034"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="32">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="32">
        <location>
            <begin position="1708"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="1816"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="2034"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="2072"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="1067"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="30">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00024012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00024028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00034112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00045450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="SMART" id="SM01062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2090" mass="236436" checksum="A865C138CC8A4D72" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Y3</accession>
    <name>A0A5F8G3Y3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CUB and Sushi multiple domains 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CSMD2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CSMD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000076922.1">
        <property type="protein sequence ID" value="ENSMODP00000042184.1"/>
        <property type="gene ID" value="ENSMODG00000018179.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159768"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018179">
        <property type="expression patterns" value="Expressed in cerebellum and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000011">
        <property type="entry name" value="CUB and sushi domain-containing protein 3 isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000001">
        <property type="entry name" value="CUB and sushi domain-containing protein 3 isoform X1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000002">
        <property type="entry name" value="CUB and Sushi multiple domains 3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF6">
        <property type="entry name" value="CUB AND SUSHI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="24"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0768">Sushi</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023896928" evidence="13">
        <location>
            <begin position="19"/>
            <end position="3247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3171"/>
            <end position="3192"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="80"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="211"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="275"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="389"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="448"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="559"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="622"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="735"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="794"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="907"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="968"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1079"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="1141"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1253"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="1315"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1426"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="1489"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1603"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="1666"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1777"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="1838"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1949"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="2010"/>
            <end position="2121"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="2120"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="2183"/>
            <end position="2294"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="2294"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="2357"/>
            <end position="2420"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="2421"/>
            <end position="2485"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="2486"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="2544"/>
            <end position="2601"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="2602"/>
            <end position="2664"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="2665"/>
            <end position="2722"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="2726"/>
            <end position="2783"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="2784"/>
            <end position="2841"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="2842"/>
            <end position="2899"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="2948"/>
            <end position="3007"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="763"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1141"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2514"/>
            <end position="2541"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2572"/>
            <end position="2599"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2635"/>
            <end position="2662"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2693"/>
            <end position="2720"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2754"/>
            <end position="2781"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2812"/>
            <end position="2839"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2870"/>
            <end position="2897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="3247" mass="355415" checksum="0253EE5D471A8AC6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Y6</accession>
    <name>A0A5F8G3Y6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SLU7</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Associated with the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of pre-catalytic, catalytic and post-catalytic spliceosomes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056667518.1">
        <property type="nucleotide sequence ID" value="XM_056811540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3Y6"/>
    <dbReference type="FunCoup" id="A0A5F8G3Y6">
        <property type="interactions" value="4049"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042172"/>
    <dbReference type="Ensembl" id="ENSMODT00000070704.1">
        <property type="protein sequence ID" value="ENSMODP00000042172.1"/>
        <property type="gene ID" value="ENSMODG00000007968.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100030408"/>
    <dbReference type="CTD" id="10569"/>
    <dbReference type="GeneTree" id="ENSGT00390000002292"/>
    <dbReference type="InParanoid" id="A0A5F8G3Y6"/>
    <dbReference type="OMA" id="KYAWESQ"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007968">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000389">
        <property type="term" value="P:mRNA 3'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="12">
        <location>
            <begin position="235"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="279"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="564"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="625"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="659" mass="76585" checksum="F895DDC6BB10EE58" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Y7</accession>
    <name>A0A5F8G3Y7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Choline/ethanolamine transporter FLVCR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Heme transporter FLVCR1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FLVCR1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis. Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids. Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane. Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline(out) = choline(in)</text>
            <dbReference type="Rhea" id="RHEA:32751"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ethanolamine(in) = ethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:32747"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>heme b(in) = heme b(out)</text>
            <dbReference type="Rhea" id="RHEA:75443"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3Y7"/>
    <dbReference type="Ensembl" id="ENSMODT00000074099.1">
        <property type="protein sequence ID" value="ENSMODP00000042161.1"/>
        <property type="gene ID" value="ENSMODG00000039454.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234625"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000039454">
        <property type="expression patterns" value="Expressed in spermatocyte and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043249">
        <property type="term" value="P:erythrocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000184">
        <property type="entry name" value="Feline leukemia virus subgroup C receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF2">
        <property type="entry name" value="HEME TRANSPORTER FLVCR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0265">Erythrocyte maturation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="20">
        <location>
            <begin position="117"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="536" mass="58496" checksum="2F42CB4C8E48A565" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Y8</accession>
    <name>A0A5F8G3Y8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centromere protein N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CENPN</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-N/CHL4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3Y8"/>
    <dbReference type="Ensembl" id="ENSMODT00000068226.1">
        <property type="protein sequence ID" value="ENSMODP00000042177.1"/>
        <property type="gene ID" value="ENSMODG00000015271.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004738"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015271">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052011">
        <property type="entry name" value="CENP-NAC/CAD_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46790">
        <property type="entry name" value="CENTROMERE PROTEIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46790:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="128" mass="15201" checksum="EC5D95DBB0ABBA4D" modified="2019-12-11" version="1">MDEIVAEFIRRTLLKIPAVDILKILKIWNFLPESQLETIKLHQCKESLSQDVVELCQVIIINWYHQTCPNRKIWTVYEMTKFPGEEVDLSDMEEFKDSFKKILQRNLRNGTRTKMKNSSHSQELGVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Z0</accession>
    <name>A0A5F8G3Z0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PTPRM</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="Ensembl" id="ENSMODT00000066502.1">
        <property type="protein sequence ID" value="ENSMODP00000042158.1"/>
        <property type="gene ID" value="ENSMODG00000021453.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155020"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021453">
        <property type="expression patterns" value="Expressed in heart and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14633">
        <property type="entry name" value="R-PTPc-M-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14635">
        <property type="entry name" value="R-PTPc-M-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000003">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase kappa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000005">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase kappa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000019">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase kappa isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000006">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase T isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000152">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase T isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000009">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000025">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045911">
        <property type="entry name" value="R-PTP-mu_cat_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF11">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00740">
        <property type="entry name" value="MAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="21">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="124"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="23">
        <location>
            <begin position="222"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="23">
        <location>
            <begin position="320"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="23">
        <location>
            <begin position="419"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="19">
        <location>
            <begin position="842"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="20">
        <location>
            <begin position="1013"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="19">
        <location>
            <begin position="1128"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="20">
        <location>
            <begin position="1304"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1394" mass="157763" checksum="211727124F93D83A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Z1</accession>
    <name>A0A5F8G3Z1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TTC27</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC27 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3Z1"/>
    <dbReference type="Ensembl" id="ENSMODT00000086255.1">
        <property type="protein sequence ID" value="ENSMODP00000042182.1"/>
        <property type="gene ID" value="ENSMODG00000015440.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044929"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015440">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="486"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="554"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="802" mass="92113" checksum="3BDEAB4B91FFB0F8" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Z3</accession>
    <name>A0A5F8G3Z3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Keratin, type I cytoskeletal 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100013604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3Z3"/>
    <dbReference type="Ensembl" id="ENSMODT00000058612.1">
        <property type="protein sequence ID" value="ENSMODP00000042171.1"/>
        <property type="gene ID" value="ENSMODG00000014608.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154403"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014608">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF121">
        <property type="entry name" value="KERATIN, TYPE I CYTOSKELETAL 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="86"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="189"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="425" mass="46985" checksum="0E87FFBA97124D5E" modified="2019-12-11" version="1">MTSSYSYRQSSSTSTLGMGTNNPIRFGSGVALRAPSIHGGSGGRGVSVSRFVSSGLSGSYGGGSSSSCSSFSLGYGGADGLLAGNEKFTMQNLNDRLASYLDKVRALEEANSDLEVKIRDWYQKQGPGPSRDYSAYLKTIEDLRDKILGATIENSKIVLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIEGLKEELAYLKKNHEEEMKEYSNQVVGQVNVEMDATPGIDLTRTLAEMREQYEALAEKNRRDAENWFQQKSEELNKEVTTNTEMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLEASVAETECRYAMQLQQIQGLISSIEAQLSDIRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLDGQDSKMTGFTTSGTTSISSNSSSSANVSAGTRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Z7</accession>
    <name>A0A5F8G3Z7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcyphosine like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CAPSL</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3Z7"/>
    <dbReference type="STRING" id="13616.ENSMODP00000042176"/>
    <dbReference type="Ensembl" id="ENSMODT00000086379.1">
        <property type="protein sequence ID" value="ENSMODP00000042176.1"/>
        <property type="gene ID" value="ENSMODG00000020365.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156466"/>
    <dbReference type="InParanoid" id="A0A5F8G3Z7"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020365">
        <property type="expression patterns" value="Expressed in uterus and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF5">
        <property type="entry name" value="CALCYPHOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="213" mass="24577" checksum="318D4E33222F7427" modified="2019-12-11" version="1">MSGTARHDREMAIQAKKRLVTATDPIERLRLQCLARGSAGIKGLGRVFRIMDDDNSRTIDFKEFMKGLNDYAVVMEKEEAQELFSRFDKDRNGKIDFDEFLLTLRPPMSRARKEVIMQAFRKLDKTGDGVITIEDLRGVYNVKHHPKYQNGEWSEEQVFRKFLDNFDSPYDKDGLLTAAFLGGCTLWIIQLHFWVLFFPALGVLSLLFSPCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3Z9</accession>
    <name>A0A5F8G3Z9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein 241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMEM241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3Z9"/>
    <dbReference type="Ensembl" id="ENSMODT00000070729.1">
        <property type="protein sequence ID" value="ENSMODP00000042150.1"/>
        <property type="gene ID" value="ENSMODG00000027607.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048348"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000027607">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="284" mass="31795" checksum="FD2B9C1A4FF41F76" modified="2019-12-11" version="1">MQTKRPFPGLTFCAFYLATYLTNKYVLSVLNFTYPTLFQGWQTLIGGLLLHISWKLGWVEINSNCRAKVLSWLPFSMLFVGIIYAGSRALSRLSIPVFFTFHNASEVIVCLYQKCISKEPTSPAKICSVVFLLAAAGCLPFYDSQLDTIGYFWAAIHLFCVGAYKILHKDRKSNTLSMVLLAFASHPTGDLFRALEFPFLYFYRFHTSCCASGFLGFFLMLSSVKLKNNMAPGQHTAWIFFAKVMTAGSSILLFDTVLNIAMVACLLLGGLGEALLVYSERMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G466</accession>
    <name>A0A5F8G466_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cyclin-dependent kinase 14</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cell division protein kinase 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">CDK14</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Found in a complex with LRP6, CCNY and CAPRIN2 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus. Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="RefSeq" id="XP_007505058.1">
        <property type="nucleotide sequence ID" value="XM_007504996.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G466"/>
    <dbReference type="Ensembl" id="ENSMODT00000084012.1">
        <property type="protein sequence ID" value="ENSMODP00000042251.1"/>
        <property type="gene ID" value="ENSMODG00000010497.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021354"/>
    <dbReference type="KEGG" id="mdo:100021354"/>
    <dbReference type="CTD" id="5218"/>
    <dbReference type="GeneTree" id="ENSGT00940000157640"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010497">
        <property type="expression patterns" value="Expressed in spermatocyte and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07869">
        <property type="entry name" value="STKc_PFTAIRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000131">
        <property type="entry name" value="cyclin-dependent kinase 14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000007">
        <property type="entry name" value="Cyclin-dependent kinase 14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF154">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="95"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="429" mass="48404" checksum="3BB4752DB4C4110F" modified="2019-12-11" version="1">MICVTKMSTRNCPGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPATQVKRVHSENNACINFKSSSSGKESPKARRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVYSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCFPKNRLSAPAALNHEYFSDLPPRLWELTDMSSVFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G467</accession>
    <name>A0A5F8G467_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger matrin-type 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZMAT4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G467"/>
    <dbReference type="Ensembl" id="ENSMODT00000088694.1">
        <property type="protein sequence ID" value="ENSMODP00000042239.1"/>
        <property type="gene ID" value="ENSMODG00000010499.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100033007"/>
    <dbReference type="GeneTree" id="ENSGT00940000156888"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010499">
        <property type="expression patterns" value="Expressed in spinal cord and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051868">
        <property type="entry name" value="ZN346_ZMAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46144:SF3">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46144">
        <property type="entry name" value="ZINC FINGER PROTEIN 385B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="225" mass="25306" checksum="F15EC418152F79A8" modified="2019-12-11" version="1">MLSIFFQSRKHASKVRLYYMLHPVDGGCPAKKLRSENGSDDDMVDKNKCCTLCNMSFTSAVVADSHYQGKIHAKRLKLLLGEQPPVKAAGNAGKEQRVEHNEATQLEELRETPLSPLKPPHSASAPGVPVSSPHRRRDSDRYCQLCAAWFNNPLMAQQHYEGKKHKKNAARVDLLEQLGKTLDLGELRGLRRSYTCSICHVTLNSIEQYHAHLKGSKHQTNLKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G468</accession>
    <name>A0A5F8G468_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin binding protein C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MYBPC1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the immunoglobulin superfamily. MyBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G468"/>
    <dbReference type="Ensembl" id="ENSMODT00000056982.1">
        <property type="protein sequence ID" value="ENSMODP00000042257.1"/>
        <property type="gene ID" value="ENSMODG00000003026.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158254"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003026">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05894">
        <property type="entry name" value="Ig_C5_MyBP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000286">
        <property type="entry name" value="Myosin binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000326">
        <property type="entry name" value="Myosin-binding protein C, cardiac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000060">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000062">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000070">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000081">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000085">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000111">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040849">
        <property type="entry name" value="MyBP-C_THB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF27">
        <property type="entry name" value="MYOSIN-BINDING PROTEIN C, SLOW-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18362">
        <property type="entry name" value="THB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="363"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="545"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="645"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="797"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="894"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1130" mass="126632" checksum="185921F56A7EA324" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G471</accession>
    <name>A0A5F8G471_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Structural maintenance of chromosomes protein 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G471"/>
    <dbReference type="Ensembl" id="ENSMODT00000086106.1">
        <property type="protein sequence ID" value="ENSMODP00000042244.1"/>
        <property type="gene ID" value="ENSMODG00000003893.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074816"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003893">
        <property type="expression patterns" value="Expressed in placenta and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000959">
        <property type="entry name" value="structural maintenance of chromosomes protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="16">
        <location>
            <begin position="54"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1019"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="361"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="630"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1042" mass="119338" checksum="A365EC6833EF087E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G472</accession>
    <name>A0A5F8G472_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G472"/>
    <dbReference type="Ensembl" id="ENSMODT00000054119.1">
        <property type="protein sequence ID" value="ENSMODP00000042225.1"/>
        <property type="gene ID" value="ENSMODG00000050187.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000050187">
        <property type="expression patterns" value="Expressed in spermatid and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="102"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="189"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="278"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="365"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="454"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="541"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="630"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="717"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="806"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="893"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1000" mass="109265" checksum="DAFE078854DFCEE7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G473</accession>
    <name>A0A5F8G473_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Vomeronasal 2 receptor 589</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">VN2R589</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G473"/>
    <dbReference type="Ensembl" id="ENSMODT00000085984.1">
        <property type="protein sequence ID" value="ENSMODP00000042253.1"/>
        <property type="gene ID" value="ENSMODG00000047058.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154249"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000047058">
        <property type="expression patterns" value="Expressed in spermatid and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06365">
        <property type="entry name" value="PBP1_pheromone_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000125">
        <property type="entry name" value="Vomeronasal 2, receptor 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF545">
        <property type="entry name" value="VOMERONASAL 2, RECEPTOR 118-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="505"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="769" mass="87059" checksum="0D0B1F563388A253" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G474</accession>
    <name>A0A5F8G474_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 21">Kit ligand</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">c-Kit ligand</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">KITLG</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer, non-covalently linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 21">Belongs to the SCF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016281181.1">
        <property type="nucleotide sequence ID" value="XM_016425695.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G474"/>
    <dbReference type="Ensembl" id="ENSMODT00000055307.1">
        <property type="protein sequence ID" value="ENSMODP00000042249.1"/>
        <property type="gene ID" value="ENSMODG00000046786.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100021399"/>
    <dbReference type="CTD" id="4254"/>
    <dbReference type="GeneTree" id="ENSGT00390000018272"/>
    <dbReference type="OrthoDB" id="8445223at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000046786">
        <property type="expression patterns" value="Expressed in lung and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005173">
        <property type="term" value="F:stem cell factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.10:FF:000004">
        <property type="entry name" value="Kit ligand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003452">
        <property type="entry name" value="SCF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11574">
        <property type="entry name" value="KIT LIGAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11574:SF0">
        <property type="entry name" value="KIT LIGAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02404">
        <property type="entry name" value="SCF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015599">
        <property type="entry name" value="SCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 21" id="KW-0339">Growth factor</keyword>
    <keyword evidence="16 21 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="12 24" id="KW-0732">Signal</keyword>
    <keyword evidence="11 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023842326" description="Kit ligand" evidence="24">
        <location>
            <begin position="26"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="68"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR015599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR015599-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="245" mass="28206" checksum="B51DAFAAA3566526" modified="2019-12-11" version="1">MKKTQTWIITCIYLQLLLFNPLVKTKGICGNPVTDDVKEITTLVANLPNDYMIPLKYVPDMELLPNHCWLHLMVPELARSLNNLLDKFSKISSSLSNYSIIDKLIKIIDDLMGCLEEKNKNFRKQNIHIYKRDSFNPEDFFRFFNKSIDAFKEYEETSEHSNCVLPSTIGPERGKAAGSTKDPSVQWVAIVLPSLFSLVLGFVLGALYWKKKQMNLKMEVENIETSEEDNEISMLQENDGEFQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G475</accession>
    <name>A0A5F8G475_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubby-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G475"/>
    <dbReference type="Ensembl" id="ENSMODT00000063382.1">
        <property type="protein sequence ID" value="ENSMODP00000042262.1"/>
        <property type="gene ID" value="ENSMODG00000013699.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161908"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013699">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.90.10:FF:000001">
        <property type="entry name" value="Tubby-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018066">
        <property type="entry name" value="Tubby_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005398">
        <property type="entry name" value="Tubby_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF24">
        <property type="entry name" value="TUBBY-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16322">
        <property type="entry name" value="Tub_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01200">
        <property type="entry name" value="TUB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01201">
        <property type="entry name" value="TUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tubby N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Tubby C-terminal" evidence="8">
        <location>
            <begin position="337"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="586" mass="65251" checksum="21BBE0C1841AAF9D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G477</accession>
    <name>A0A5F8G477_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endosomal/lysosomal proton channel TMEM175</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Potassium channel TMEM175</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 175</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TMEM175</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>H(+)(in) = H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G477"/>
    <dbReference type="Ensembl" id="ENSMODT00000060238.1">
        <property type="protein sequence ID" value="ENSMODP00000042230.1"/>
        <property type="gene ID" value="ENSMODG00000005555.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015667"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005555">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31462">
        <property type="entry name" value="ENDOSOMAL/LYSOSOMAL POTASSIUM CHANNEL TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31462:SF5">
        <property type="entry name" value="ENDOSOMAL_LYSOSOMAL PROTON CHANNEL TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="243" mass="27308" checksum="CA3F8C420D0EC613" modified="2019-12-11" version="1">MAGAETPEEDTDVQMELSADTGDENSCENTQSSHRMLSFSDALLSIIATVMILPVAHTKIYPDQRFDKSIQKLLATKIAVYLMTFLIVTVAWAAHIRLFQIIGMIDDTLALLNLACMMIITFLPYTFSLMASFPDVPLGIFLFCICVIAIGLSQAAIVTYGFHYPYLLNRQIQQSENKAFYKQHILNIILRGPALCFFAAIFSFFFFPVCSRLNAISTMPSTNWNIWETSSSIRNPSSVWILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G479</accession>
    <name>A0A5F8G479_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear receptor subfamily 2 group C member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NR2C1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G479"/>
    <dbReference type="Ensembl" id="ENSMODT00000067774.1">
        <property type="protein sequence ID" value="ENSMODP00000042235.1"/>
        <property type="gene ID" value="ENSMODG00000008267.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158165"/>
    <dbReference type="OMA" id="XVQCERK"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008267">
        <property type="expression patterns" value="Expressed in heart and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06967">
        <property type="entry name" value="NR_DBD_TR2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06952">
        <property type="entry name" value="NR_LBD_TR2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000012">
        <property type="entry name" value="Nuclear receptor subfamily 2 group C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000015">
        <property type="entry name" value="Nuclear receptor subfamily 2, group C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048245">
        <property type="entry name" value="NR2C1/2-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048246">
        <property type="entry name" value="NR2C1/2-like_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="111"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="346"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="605" mass="67217" checksum="01DC2AB69E2E69F6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G481</accession>
    <name>A0A5F8G481_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calmodulin regulated spectrin associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CAMSAP1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The CKK domain binds microtubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CAMSAP1 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000070895.1">
        <property type="protein sequence ID" value="ENSMODP00000042263.1"/>
        <property type="gene ID" value="ENSMODG00000017535.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182975"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017535">
        <property type="expression patterns" value="Expressed in spinal cord and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030507">
        <property type="term" value="F:spectrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.360:FF:000001">
        <property type="entry name" value="Calmodulin-regulated spectrin-associated protein 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.360">
        <property type="entry name" value="CKK domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032940">
        <property type="entry name" value="CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031372">
        <property type="entry name" value="CAMSAP_CC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058042">
        <property type="entry name" value="CAMSAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022613">
        <property type="entry name" value="CH_CAMSAP_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014797">
        <property type="entry name" value="CKK_CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038209">
        <property type="entry name" value="CKK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595:SF3">
        <property type="entry name" value="CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17095">
        <property type="entry name" value="CAMSAP_CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11971">
        <property type="entry name" value="CAMSAP_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08683">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25532">
        <property type="entry name" value="CH_CAMSAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01051">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51508">
        <property type="entry name" value="CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="120"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="CKK" evidence="10">
        <location>
            <begin position="1378"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="684"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="740"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="968"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1226"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="787"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="933"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1226"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1276"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1295"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1308"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1517" mass="170171" checksum="144F69FFDD52675E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G485</accession>
    <name>A0A5F8G485_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat and sterile alpha motif domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ANKS3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G485"/>
    <dbReference type="FunCoup" id="A0A5F8G485">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042268"/>
    <dbReference type="Ensembl" id="ENSMODT00000068263.1">
        <property type="protein sequence ID" value="ENSMODP00000042268.1"/>
        <property type="gene ID" value="ENSMODG00000006338.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156610"/>
    <dbReference type="InParanoid" id="A0A5F8G485"/>
    <dbReference type="OMA" id="RKDVHTQ"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006338">
        <property type="expression patterns" value="Expressed in kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09519">
        <property type="entry name" value="SAM_ANKS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047238">
        <property type="entry name" value="ANKS3_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184:SF6">
        <property type="entry name" value="ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184">
        <property type="entry name" value="SI:CH211-189E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="426"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="665" mass="73474" checksum="FE92AFCF985362DA" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G488</accession>
    <name>A0A5F8G488_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Neuronal acetylcholine receptor subunit alpha-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">CHRNA5</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNB2 and CHRNB4. Increases receptor sensitivity to acetylcholine and nicotine when associated with CHRNA4 and CHRNB2. Plays a role in nicotine addiction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Neuronal AChR that forms heteropentamers composed of two different type of subunits: alpha and non-alpha (beta). CHRNA5/alpha-5 subunit is only able to form functional nAChRs when co-assembled with another alpha subunit, can be combined to CHRNA4/alpha-4 or CHRNA3/alpha-3 and CHRNB4/beta-4 or CHRNB2/beta-2 to give rise to functional receptors. Interacts with LYPD6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G488"/>
    <dbReference type="Ensembl" id="ENSMODT00000086640.1">
        <property type="protein sequence ID" value="ENSMODP00000042259.1"/>
        <property type="gene ID" value="ENSMODG00000011857.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159270"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011857">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035094">
        <property type="term" value="P:response to nicotine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000041">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000047">
        <property type="entry name" value="neuronal acetylcholine receptor subunit alpha-5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 22" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="23">
        <location>
            <begin position="29"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="24">
        <location>
            <begin position="239"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="24">
        <location>
            <begin position="367"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00040005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00056979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="450" mass="52001" checksum="FCCCE1FE62C57683" modified="2019-12-11" version="1">MVIIKIDIFAFFHFPFFRISEPSFEAKCEDRLFKNLFQDYERWVRPVKHLNDKINIKFGLAISQLVDVDEKNQLMTTNVWLKQEWVDVKLRWNPDDYAGIKAIRVPSDSIWTPDIVLFDNADGRFEGTSTKTVVRYDGTVAWTPPGNYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDLVLEDYDVDKRDFFDNGEWEIVSATGIKGNRTDGCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAININHRSSSTHNPMAPWVRKIFLHQLPKLLCMRSHVDRYFAHKEGAEKSNGARSPRNTLEAALDSIRYITRHVRKENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGSLGLFVPVIYKWANIPITNHTGNANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G490</accession>
    <name>A0A5F8G490_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G490"/>
    <dbReference type="Ensembl" id="ENSMODT00000052894.1">
        <property type="protein sequence ID" value="ENSMODP00000042273.1"/>
        <property type="gene ID" value="ENSMODG00000040381.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154572"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000040381">
        <property type="expression patterns" value="Expressed in spinal cord and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd01274">
        <property type="entry name" value="PTB_Anks"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000045">
        <property type="entry name" value="Ankyrin repeat and sterile alpha motif domain-containing protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF3">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="89"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="290" mass="32923" checksum="1919EB672742D36E" modified="2019-12-11" version="1">MQGDARRRRNENYFDDIPRSKLERQMAQSSVCEIWTNQNAGFPFSAIHQVHNTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPAKPIPKPRVSIRKSVQIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G492</accession>
    <name>A0A5F8G492_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgin subfamily A conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GOLGA2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_056668469.1">
        <property type="nucleotide sequence ID" value="XM_056812491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G492"/>
    <dbReference type="Ensembl" id="ENSMODT00000058683.1">
        <property type="protein sequence ID" value="ENSMODP00000042250.1"/>
        <property type="gene ID" value="ENSMODG00000005915.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100012662"/>
    <dbReference type="CTD" id="2801"/>
    <dbReference type="GeneTree" id="ENSGT00530000062932"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005915">
        <property type="expression patterns" value="Expressed in heart and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024858">
        <property type="entry name" value="GOLGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043937">
        <property type="entry name" value="GOLGA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043976">
        <property type="entry name" value="GOLGA_cons_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10881:SF46">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10881">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19046">
        <property type="entry name" value="GM130_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15070">
        <property type="entry name" value="GOLGA2L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A conserved" evidence="4">
        <location>
            <begin position="377"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="895"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="783"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="995" mass="112740" checksum="6934A6419ECAACB8" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G496</accession>
    <name>A0A5F8G496_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho guanine nucleotide exchange factor 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ARHGEF10</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in developmental myelination of peripheral nerves.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000061483.1">
        <property type="protein sequence ID" value="ENSMODP00000042282.1"/>
        <property type="gene ID" value="ENSMODG00000014194.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100032494"/>
    <dbReference type="CTD" id="9639"/>
    <dbReference type="GeneTree" id="ENSGT00940000153798"/>
    <dbReference type="OrthoDB" id="28697at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014194">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000340">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000003">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 10 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF14">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="367"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1174"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1225"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="537"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1227"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1318" mass="146939" checksum="9E5A5201943EE655" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G497</accession>
    <name>A0A5F8G497_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HECT and RLD domain containing E3 ubiquitin protein ligase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HERC4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G497"/>
    <dbReference type="Ensembl" id="ENSMODT00000078241.1">
        <property type="protein sequence ID" value="ENSMODP00000042260.1"/>
        <property type="gene ID" value="ENSMODG00000017265.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158924"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017265">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000012">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000014">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HERC4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="103"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="156"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="209"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="314"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="730"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="800"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="4">
        <location>
            <position position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="979" mass="109689" checksum="3616A7166413113F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G498</accession>
    <name>A0A5F8G498_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endomucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EMCN</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G498"/>
    <dbReference type="Ensembl" id="ENSMODT00000056332.1">
        <property type="protein sequence ID" value="ENSMODP00000042283.1"/>
        <property type="gene ID" value="ENSMODG00000027935.2"/>
    </dbReference>
    <dbReference type="GeneID" id="103096280"/>
    <dbReference type="CTD" id="51705"/>
    <dbReference type="GeneTree" id="ENSGT00390000012139"/>
    <dbReference type="OrthoDB" id="9632909at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000027935">
        <property type="expression patterns" value="Expressed in kidney and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010740">
        <property type="entry name" value="Endomucin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15869:SF0">
        <property type="entry name" value="ENDOMUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15869">
        <property type="entry name" value="ENDOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07010">
        <property type="entry name" value="Endomucin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023911435" evidence="3">
        <location>
            <begin position="20"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="260" mass="27765" checksum="8B80B8D04E0A6CE2" modified="2019-12-11" version="1">MKLLQGTVLFLSLCSLCYSQESQVSEKPLMTTVQSTIIVPKSPSPSSEKILESVPTAMITQGKLKTTEATTSPKTSSSLIYSTSTNTEILKELSSTPMIATSSSPSSAVAKTARGTPQNDTSSDVSSTASPQVSTHQLQTTVSTKQSSQQNNETLKFITTPPIKDQGSTRDSGTTSSLLINSSYSSVILPVVIALIAITLSIFILVGLYRMCWKTDPGTPDNGTDQPQSDKESVKLLTVKTISPETSVKMQIATCDKRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G499</accession>
    <name>A0A5F8G499_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="28">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="primary">ATP11A</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21 28">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="24">Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP11A and an accessory beta subunit TMEM30A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Membrane</location>
            <topology evidence="28">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 28">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="28"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G499"/>
    <dbReference type="Ensembl" id="ENSMODT00000062131.1">
        <property type="protein sequence ID" value="ENSMODP00000042265.1"/>
        <property type="gene ID" value="ENSMODG00000004191.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157849"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004191">
        <property type="expression patterns" value="Expressed in endometrium and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010831">
        <property type="term" value="P:positive regulation of myotube differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000016">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000012">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF33">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE IH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 26 28" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="19" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="16 27 28" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 27" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 26 28" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17 28" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="881"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="911"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="961"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="995"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="1029"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="1059"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="30">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="29">
        <location>
            <begin position="127"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="31">
        <location>
            <begin position="847"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="25">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="687"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="689"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="794"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="800"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="821"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00065117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1130" mass="129284" checksum="EA60F1D223663F64" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUX6</accession>
    <name>A0A5F8GUX6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PHD finger protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PHF24</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUX6"/>
    <dbReference type="Ensembl" id="ENSMODT00000088813.1">
        <property type="protein sequence ID" value="ENSMODP00000051164.1"/>
        <property type="gene ID" value="ENSMODG00000007843.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002865"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007843">
        <property type="expression patterns" value="Expressed in testis and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031946">
        <property type="entry name" value="KIAA1045_Zf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46453:SF4">
        <property type="entry name" value="PHD FINGER PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46453">
        <property type="entry name" value="PROTEIN KINASE C-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16744">
        <property type="entry name" value="zf-RING_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KIAA1045 RING finger" evidence="5">
        <location>
            <begin position="137"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="383" mass="43813" checksum="36DA3B2024D2C8C3" modified="2019-12-11" version="1">MCLCSFAHRTMGVLMSKRQTVEQVQKVSLAVSAFKDGLRDRPSLRRTGEPAGSRRGTVEHSVQEVQEEDELETAAAVPQEENSVNRAAWERLRDGRGVEPEEFDHANRFTPPAFIRPIRELHDDKPLDICLEPRESVISDEMCEICEVWTAESLFPCRICTRVFHDGCLRRMGYLQGDSTVEVTEMAHTETGWSCYYCNNLNLLLTEEEMYSLMENFQQCKIIPDCSLTLEDFLRYRHQAARRGGSERALSEEQEERAAQQFAALDPEHRGHVEWPDFLSHESLQLLQQLRPQNSLLRLLTVKERERARTAFLARDTGGYISETECRRAQHTWFRKRPLDAPSCNVSISHVGPISESSPASSSSAKSPEKPLQTAEQEEPRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUX7</accession>
    <name>A0A5F8GUX7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mago homolog B, exon junction complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MAGOHB</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUX7"/>
    <dbReference type="Ensembl" id="ENSMODT00000067646.1">
        <property type="protein sequence ID" value="ENSMODP00000051433.1"/>
        <property type="gene ID" value="ENSMODG00000000462.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003156"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000462">
        <property type="expression patterns" value="Expressed in hindlimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="109" mass="12786" checksum="A4EE35F9C321B5DB" modified="2019-12-11" version="1">MASDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUY0</accession>
    <name>A0A5F8GUY0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUY0"/>
    <dbReference type="Ensembl" id="ENSMODT00000072907.1">
        <property type="protein sequence ID" value="ENSMODP00000051169.1"/>
        <property type="gene ID" value="ENSMODG00000005317.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159769"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005317">
        <property type="expression patterns" value="Expressed in heart and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001157">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II delta 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023942227" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="159" mass="18090" checksum="B7C4F82F7C957B6C" modified="2019-12-11" version="1">IWACVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGMCINSKTNVVTSPKENIPTPALEPQTTVIHNPDGNKFPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUY2</accession>
    <name>A0A5F8GUY2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PX domain containing serine/threonine kinase like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PXK</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUY2"/>
    <dbReference type="Ensembl" id="ENSMODT00000069352.1">
        <property type="protein sequence ID" value="ENSMODP00000051438.1"/>
        <property type="gene ID" value="ENSMODG00000002378.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017669"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002378">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000039">
        <property type="entry name" value="PX domain containing serine/threonine kinase like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF40">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="116"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="465" mass="52583" checksum="CB8A7F06BF2DCB12" modified="2019-12-11" version="1">MAFMEKPPAGKVLLDDTAPLSAGIEASQSLHSHTISGLSLPLPPKKLIGNMEREFIAERQKGLQRYLDVITTNHLLANCELVKKFLDPNNYSANYTEIALQQVSMFFRSEPKWEVVEPLKDIGWRIRKRYFLMKSKNQPKERLVLSWADLGPDKYLADKDFQWLIRLLPSCSHPHIYRVTFSTASESSALVIRTFNERGTLRDLIYKAKPKEPFLRKYGSPKKAQGLELAHIKAFGRQILEALKFLHDKGFPYGHLHASNVMLEGDTCRLLDLENSLLGLPSFYRPYFSQLRRINTWERVEGRPPDAVPGDRFPPARWEAGVSVLEAVLSPEACKNGAPSVSRLLQMPLFSDVFLANSEKPQFKIPAKLKEALKVAKECIEKRLVEEQKLIHQHRRLTKAKSHHGSEEERRRRKILARKKSKRSALEGSEEHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUY4</accession>
    <name>A0A5F8GUY4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADAM metallopeptidase domain 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUY4"/>
    <dbReference type="Ensembl" id="ENSMODT00000056843.1">
        <property type="protein sequence ID" value="ENSMODP00000051174.1"/>
        <property type="gene ID" value="ENSMODG00000010545.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156239"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010545">
        <property type="expression patterns" value="Expressed in endometrium and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF136">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="191"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="10">
        <location>
            <begin position="393"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="619"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="344"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="74543" checksum="DA17B17C34B759D5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUY5</accession>
    <name>A0A5F8GUY5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloprotease TIKI</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">TRAB domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TRABD2B</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="13">Divalent metal cations. Mn(2+) or Co(2+).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the TIKI family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUY5"/>
    <dbReference type="Ensembl" id="ENSMODT00000070710.1">
        <property type="protein sequence ID" value="ENSMODP00000051355.1"/>
        <property type="gene ID" value="ENSMODG00000025378.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161273"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025378">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14789">
        <property type="entry name" value="Tiki"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040230">
        <property type="entry name" value="TIKI1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120">
        <property type="entry name" value="METALLOPROTEASE TIKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120:SF8">
        <property type="entry name" value="METALLOPROTEASE TIKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="327" mass="37356" checksum="DCE12AE455AD6FA4" modified="2019-12-11" version="1">MPLSPRLAEPVRGAERAAAPGPAQPCPQGDLNSFLWTIHRDPPAYLFGTIHVPYTRVWDFIPDNSKAAFEASARVYFELDLTDPYTISALASCQLLPHGENLQDVLPRELYRRLKRHLDYVKLMMPTWMTPDQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTETDVRSRGVPVLDLYLAQEAERMKKRTGAVERVEEQCHPLNGLNFSQVLFALNQTLLQHESLRAGSLQAPYTTEDLIKHYNCGDLNAVIFNHDSSQLPNFINTTLPPHEQATAQEIDSYFRQELIYKRNERMGRRVMALLRENGDKSFFFAFGAGRELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUY6</accession>
    <name>A0A5F8GUY6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NDRG family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NDRG3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUY6"/>
    <dbReference type="Ensembl" id="ENSMODT00000077581.1">
        <property type="protein sequence ID" value="ENSMODP00000051021.1"/>
        <property type="gene ID" value="ENSMODG00000001353.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182872"/>
    <dbReference type="OMA" id="ITQYFAV"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001353">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000006">
        <property type="entry name" value="NDRG family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="398" mass="43845" checksum="AF83B57201F41A3D" modified="2019-12-11" version="1">MAGFTLQSQSRASPPFPCLLLQCCWFPQDSVLTPVPMDELQDVQLTEIKPLLNDKEHDIETAHGVVHVTMRGSPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMHEITQHFAVCHVDAPGQQEAAPPFPTGYQYPTMDELAEMLPAVLTHLNLKGIIGIGVGAGAYILSRFALNHPELVEGLMLINIDPCAKGWIDWATSKFSGWTTNIVDIILAHHFGQEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNSRRDLEIERPVLGVNDNRTKTLKCPTLLVVGDSSPAVEAVVECNARLDPMNTTLLKMADCGGLPQVVQPGKLTEAFKYFVQGMGYIPSASMTRLLRSRTHSTSSIGSGESLYSRSLASTQSEGTPGALESADILDRPQTMEVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUZ1</accession>
    <name>A0A5F8GUZ1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pericentrin/AKAP-450 centrosomal targeting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000060896.1">
        <property type="protein sequence ID" value="ENSMODP00000051026.1"/>
        <property type="gene ID" value="ENSMODG00000008392.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000110871"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008392">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028745">
        <property type="entry name" value="AKAP9/Pericentrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981:SF3">
        <property type="entry name" value="PERICENTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981">
        <property type="entry name" value="PERICENTRIN-LIKE PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2822"/>
            <end position="2958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2994"/>
            <end position="3013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="3023"/>
            <end position="3124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="796"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="936"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1077"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1195"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1514"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1911"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2004"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2350"/>
            <end position="2676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2710"/>
            <end position="2779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2838"/>
            <end position="2849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2895"/>
            <end position="2908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2995"/>
            <end position="3006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="3079"/>
            <end position="3109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3124" mass="355594" checksum="7BAA9875E568506B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUZ2</accession>
    <name>A0A5F8GUZ2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Signal peptide, CUB and EGF-like domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SCUBE3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Forms homooligomers. Forms heterooligomers with SCUBE1 and SCUBE2. Interacts with TGFBR2 through the CUB domain; this interaction does not affect TGFB1-binding to TGFBR2. Interacts with BMP2, BMP4 and BMP7; the interaction is mediated by the CUB domain. Interacts with BMPR1A, BMPR1B and BMPR2; the interaction with BMPR1A and BMPR1B is BMP2- and BMP4-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007483795.1">
        <property type="nucleotide sequence ID" value="XM_007483733.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUZ2"/>
    <dbReference type="Ensembl" id="ENSMODT00000056466.1">
        <property type="protein sequence ID" value="ENSMODP00000051184.1"/>
        <property type="gene ID" value="ENSMODG00000013831.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100028301"/>
    <dbReference type="CTD" id="222663"/>
    <dbReference type="GeneTree" id="ENSGT00940000153185"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013831">
        <property type="expression patterns" value="Expressed in forelimb bud and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000032">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000002">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000110">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000028">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000030">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000035">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000002">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000124">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000161">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000008">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000008">
        <property type="entry name" value="Signal peptide, CUB domain, EGF-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052071">
        <property type="entry name" value="SCUB_EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046:SF2">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00907">
        <property type="entry name" value="THRMBOMODULN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023852364" description="Signal peptide, CUB and EGF-like domain-containing protein 3" evidence="12">
        <location>
            <begin position="19"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="293"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="762"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="951" mass="105264" checksum="0609F5B3BAA2CD75" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUZ4</accession>
    <name>A0A5F8GUZ4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 11 open reading frame 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C11orf42</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUZ4"/>
    <dbReference type="Ensembl" id="ENSMODT00000084087.1">
        <property type="protein sequence ID" value="ENSMODP00000051322.1"/>
        <property type="gene ID" value="ENSMODG00000018594.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016268"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018594">
        <property type="expression patterns" value="Expressed in spermatid and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031366">
        <property type="entry name" value="DUF4663"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36872">
        <property type="entry name" value="GENE 5901-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36872:SF1">
        <property type="entry name" value="GENE 5901-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15668">
        <property type="entry name" value="DUF4663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="330" mass="35851" checksum="3D8CE48CA518C3F3" modified="2019-12-11" version="1">HHGVIEERFGPNVVAVPFLADAACYDLLGVLVKQKSKPPPWLIRARLGLTFPLGLGLPRRGQRALLPVGPLPGLLERTSPEGAFAHCTREYSPKGRAEVGYEETRLVDGQPCRISLQLGGLRKRVAFLLLPPGQVGLQPALPWLRGTHSIYVIYQVFSCSWLQLALAPTACEPRQLRLQHPLPVAFSCLKFALQPKGMLGPQRPLTGDKLPREASWARPGPESTVNSVLTPPLVSTLSNTLLDSDSPPSQQPPTPPSQGAPEGRTSRFSYKGRNPFRRRPNMLSGTGKRKGTQGVSQETLGDCWGTGTGLGHGAWAAGLARTQLGRRDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUZ7</accession>
    <name>A0A5F8GUZ7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium voltage-gated channel auxiliary subunit beta 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CACNB1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUZ7"/>
    <dbReference type="Ensembl" id="ENSMODT00000071932.1">
        <property type="protein sequence ID" value="ENSMODP00000051189.1"/>
        <property type="gene ID" value="ENSMODG00000012687.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182837"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012687">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000068">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046937">
        <property type="entry name" value="CAB1-4_N_A-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005443">
        <property type="entry name" value="VDCC_L_b1su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12052">
        <property type="entry name" value="VGCC_beta4Aa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01627">
        <property type="entry name" value="LCACHANNELB1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="100"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="216" mass="23871" checksum="41457A224A377EE9" modified="2019-12-11" version="1">MVQKTSMSRASYPPTQDIPMEVFDPSLQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSRGDEAPVQGMAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRMVQEQKMRQNRLSSSKSGDNSSSSLGDVVTGTRRPTPPASGGTCPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUZ8</accession>
    <name>A0A5F8GUZ8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AT-rich interaction domain 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ARID1B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000083033.1">
        <property type="protein sequence ID" value="ENSMODP00000051453.1"/>
        <property type="gene ID" value="ENSMODG00000008068.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155634"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008068">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035060">
        <property type="term" value="C:brahma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16877">
        <property type="entry name" value="ARID_ARID1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000002">
        <property type="entry name" value="AT-rich interactive domain-containing protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038040">
        <property type="entry name" value="ARID_ARID1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021906">
        <property type="entry name" value="BAF250/Osa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033388">
        <property type="entry name" value="BAF250_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656:SF11">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656">
        <property type="entry name" value="BRG-1 ASSOCIATED FACTOR 250 BAF250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12031">
        <property type="entry name" value="BAF250_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="12">
        <location>
            <begin position="882"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="430"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="675"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="976"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1151"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1249"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1524"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1655"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="323"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="549"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="721"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="793"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1059"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1172"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1260"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1325"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1373"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1526"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1545"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1591"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1674"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2068" mass="219692" checksum="1182350870CF6D38" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUZ9</accession>
    <name>A0A5F8GUZ9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ATP10B</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="Ensembl" id="ENSMODT00000088259.1">
        <property type="protein sequence ID" value="ENSMODP00000051036.1"/>
        <property type="gene ID" value="ENSMODG00000007907.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159531"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007907">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000022">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000023">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF79">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE VB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1041"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1072"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1123"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1150"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1181"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1225"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="1009"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="606"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="714"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="781"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="858"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="860"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="957"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="963"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="983"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="986"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="987"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="987"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1324" mass="150651" checksum="85A71090CE0FB7E7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV95</accession>
    <name>A0A5F8GV95_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ETS variant transcription factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ETV5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV95"/>
    <dbReference type="FunCoup" id="A0A5F8GV95">
        <property type="interactions" value="1767"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051563"/>
    <dbReference type="Ensembl" id="ENSMODT00000084340.1">
        <property type="protein sequence ID" value="ENSMODP00000051563.1"/>
        <property type="gene ID" value="ENSMODG00000013273.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160680"/>
    <dbReference type="InParanoid" id="A0A5F8GV95"/>
    <dbReference type="OMA" id="MIPENQY"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013273">
        <property type="expression patterns" value="Expressed in lung and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000121">
        <property type="entry name" value="ETS translocation variant 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006715">
        <property type="entry name" value="ETS_PEA3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF160">
        <property type="entry name" value="ETS TRANSLOCATION VARIANT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04621">
        <property type="entry name" value="ETS_PEA3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="8">
        <location>
            <begin position="413"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="555" mass="62314" checksum="F616D0DBF8DF5788" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV97</accession>
    <name>A0A5F8GV97_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein 241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMEM241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV97"/>
    <dbReference type="Ensembl" id="ENSMODT00000061244.1">
        <property type="protein sequence ID" value="ENSMODP00000051460.1"/>
        <property type="gene ID" value="ENSMODG00000027607.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048348"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000027607">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="282" mass="31785" checksum="F3AED2C29E9A81E6" modified="2019-12-11" version="1">MQTKRPFPGLTFCAFYLATYLTNKYVLSVLNFTYPTLFQGWQTLIGGLLLHISWKLGWVEINSNCRAKVLSWLPFSMLFVGIIYAGSRALSRLSIPVFFTFHNASEVIVCLYQKCISKEPTSPAKICSVVFLLAAAGCLPFYDSQLDTIGYFWAAIHLFCVGAYKILHKDRKSNTLSDIDQQYLNYIFSMVLLAFASHPTGDLFRALEFPFLYFYRFHTSCCASGFLGFFLMLSSVKLKNNMAPGQHTAWIFFAKVMTAGSSILLFDTVLNIAMVACYGTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6X6</accession>
    <name>A0A5F8H6X6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Olfactomedin 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">OLFM4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6X6"/>
    <dbReference type="Ensembl" id="ENSMODT00000060498.1">
        <property type="protein sequence ID" value="ENSMODP00000054976.1"/>
        <property type="gene ID" value="ENSMODG00000047878.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100013736"/>
    <dbReference type="KEGG" id="mdo:100013736"/>
    <dbReference type="CTD" id="10562"/>
    <dbReference type="GeneTree" id="ENSGT00940000155454"/>
    <dbReference type="OrthoDB" id="8626508at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000047878">
        <property type="expression patterns" value="Expressed in ovary and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF7">
        <property type="entry name" value="OLFACTOMEDIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023887788" evidence="5">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Olfactomedin-like" evidence="6">
        <location>
            <begin position="202"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="469" mass="54127" checksum="FBCF329166DE142D" modified="2019-12-11" version="1">MMTKGLALLLAFLHLQTTSITGQLHPELYSNFNGSVDDRGICTCSVVLPDTSFPVQKVESLEITAHDLTQRFEKELTKVKEYTKTMQLFEQKLLNLSIKVQVMEETSISYNKLDFELLKLEVSEMQKLVTALKSNFDGSSVIIDQLELEIRNMTLLVEELESLDKNNILAIRREIVALKNRLKECEESRGQNNTHPFIPPGSCGHGGVENISKPFVVRINWRGSGYKYGAWGRDYTPQEPAKTLYWEAPLNTDGRYLEYYRLYNTLDDLLLYRLAKENRVRLGDGSGMVVYNNFMYFNYYGTRDMAKLDLNSNTVTLRRALPDAAFNNRFSYAGVNWQDMDFAVDESGLWVVYSTEASTGNIVISKINDTSLEVLNTWHTLQYKPSVSNTFIVCGVLYAIRPMNTRKEEIFYYYDTNTRKEGRISIIIEKMLETIQSVNYHPLDQKLYVYNDAYLLTYDLTYQKESEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6X7</accession>
    <name>A0A5F8H6X7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">OTUB2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C65 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6X7"/>
    <dbReference type="Ensembl" id="ENSMODT00000076887.1">
        <property type="protein sequence ID" value="ENSMODP00000055309.1"/>
        <property type="gene ID" value="ENSMODG00000049550.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006979"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000049550">
        <property type="expression patterns" value="Expressed in spermatid and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22764">
        <property type="entry name" value="OTUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.20:FF:000001">
        <property type="entry name" value="Ubiquitin thioesterase OTUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016615">
        <property type="entry name" value="Otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF3">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013503">
        <property type="entry name" value="Ubiquitin_thioesterase_Otubain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="10">
        <location>
            <begin position="51"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR013503-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR013503-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="246" mass="28356" checksum="3261EBF940854F18" modified="2019-12-11" version="1">MGGPQLKLEAIESESSFNLISEKCDILSILCDHPENRIYQRKIQELSKRFSALRKTKGDGNCFYRALGYSYLESLIGNSREILRFKERVLQTPKDLLAAGFEEHKFRNFFNAFYSLVEMVEKDGSVSNLLKVFNDQSFSDRIVQFLRLLTSAFIKNRADFFRHFIDEEMDVKDFCAQEVEPMATECDHVQITALSQALNIPLQVEYVDEMDTALNHHVFSEAACPSVYLLYKTSHYNILYAADKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6X8</accession>
    <name>A0A5F8H6X8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase 40 ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6X8"/>
    <dbReference type="Ensembl" id="ENSMODT00000059518.1">
        <property type="protein sequence ID" value="ENSMODP00000055698.1"/>
        <property type="gene ID" value="ENSMODG00000007745.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167884"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007745">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057763">
        <property type="entry name" value="UBL_USP40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25822">
        <property type="entry name" value="UBL_USP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin carboxyl-terminal hydrolase 40 ubiquitin-like" evidence="1">
        <location>
            <begin position="370"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="774" mass="88167" checksum="705BD9C201D211EF" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Y3</accession>
    <name>A0A5F8H6Y3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase MINDY</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Y3"/>
    <dbReference type="Ensembl" id="ENSMODT00000066566.1">
        <property type="protein sequence ID" value="ENSMODP00000055745.1"/>
        <property type="gene ID" value="ENSMODG00000020872.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159600"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020872">
        <property type="expression patterns" value="Expressed in spermatid and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059022">
        <property type="entry name" value="MINDY4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF8">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26038">
        <property type="entry name" value="Dimer_MINDY4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Deubiquitinating enzyme MINDY-3/4 conserved" evidence="9">
        <location>
            <begin position="214"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="506" mass="56742" checksum="3847333B1180A6E7" modified="2025-10-08" version="2">MDTQIVSLGLKKTSLVMDQEHPRGEHSINNRNELRKVLHLEMLYKENKVKKNPLKTSLEIITSYFLDHFGKNTYSLIQETPLSIVSASKMNNKLPLKCSENSAVNNNHTCELSDEDGKNRYLLPLVLDTSRISCSWKAIFSSLESVQMAEPLELKRMSDFRLKAGLFARGSLSGPIVTEVRAGGQDLGRDGGRRPPFRGPLILMNHFLLFKEIKTLLFGSNLCGFNEEWKVQNFTFSEVSQLRYGLVQNKGGPCGVLAAVQGCVLKNLLFGGESRTTSIRASGMQQFSPAGSYKADGVLEMLVLHKVAKYDDLLVFLQQNIHQFQTGPSGCILLTLSAVLSRSTDQVRKDFDMPTNCLIGAHGYCTQELVNLLLTGKAVSNVFNDMVELDSGNGNITLLKGITSRSDIGLLSLFEHYDVCQVGCYLKTPRYPIWVVCSESHFSILFSLQRDLLNDWKVERIFDLYYYDGLANQQKEIRLTVDTTQPGPGEKEKDLIPPLEHCIRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Y7</accession>
    <name>A0A5F8H6Y7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="15">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PPIP5K1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
            <location evidence="2 15">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="15"/>
    <dbReference type="RefSeq" id="XP_056666334.1">
        <property type="nucleotide sequence ID" value="XM_056810356.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000066522.1">
        <property type="protein sequence ID" value="ENSMODP00000055750.1"/>
        <property type="gene ID" value="ENSMODG00000017788.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100011533"/>
    <dbReference type="CTD" id="9677"/>
    <dbReference type="GeneTree" id="ENSGT00390000009048"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017788">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000001">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF11">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="17">
        <location>
            <begin position="55"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="910"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1107"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1254"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1376"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="988"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1141"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1302"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1317"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1401" mass="156062" checksum="A6373C0BE211BCC3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Y8</accession>
    <name>A0A5F8H6Y8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NDC80</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Y8"/>
    <dbReference type="Ensembl" id="ENSMODT00000055022.1">
        <property type="protein sequence ID" value="ENSMODP00000054986.1"/>
        <property type="gene ID" value="ENSMODG00000021471.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018386"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021471">
        <property type="expression patterns" value="Expressed in blood and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000002">
        <property type="entry name" value="NDC80, kinetochore complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040967">
        <property type="entry name" value="DUF5595"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057091">
        <property type="entry name" value="NDC80_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18077">
        <property type="entry name" value="DUF5595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24487">
        <property type="entry name" value="NDC80_loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="55"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5595" evidence="15">
        <location>
            <begin position="217"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="16">
        <location>
            <begin position="380"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="16">
        <location>
            <begin position="466"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="338"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="470"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="617" mass="71476" checksum="ABC0CEF58F36F21B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Y9</accession>
    <name>A0A5F8H6Y9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NBAS subunit of NRZ tethering complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NBAS</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000058002.1">
        <property type="protein sequence ID" value="ENSMODP00000055557.1"/>
        <property type="gene ID" value="ENSMODG00000010343.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012474"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010343">
        <property type="expression patterns" value="Expressed in testis and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054751">
        <property type="entry name" value="NBAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029145">
        <property type="entry name" value="NBAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22913">
        <property type="entry name" value="NBAS_11th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15492">
        <property type="entry name" value="Nbas_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Neuroblastoma-amplified sequence N-terminal" evidence="7">
        <location>
            <begin position="95"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="963"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="NBAS subunit of NRZ tethering complex C-terminal" evidence="8">
        <location>
            <begin position="1758"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1688"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2114" mass="235082" checksum="AE10EE222CA30A93" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Z0</accession>
    <name>A0A5F8H6Z0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metal transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CNNM2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Metal transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ACDP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001369152.1">
        <property type="nucleotide sequence ID" value="XM_001369115.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Z0"/>
    <dbReference type="Ensembl" id="ENSMODT00000074398.1">
        <property type="protein sequence ID" value="ENSMODP00000055319.1"/>
        <property type="gene ID" value="ENSMODG00000011165.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100022652"/>
    <dbReference type="CTD" id="54805"/>
    <dbReference type="GeneTree" id="ENSGT00940000159034"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011165">
        <property type="expression patterns" value="Expressed in blood and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000001">
        <property type="entry name" value="Putative metal transporter CNNM3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057492">
        <property type="entry name" value="Ig_CNNM1/2/4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF22">
        <property type="entry name" value="METAL TRANSPORTER CNNM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25562">
        <property type="entry name" value="CNBH_CNNM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25511">
        <property type="entry name" value="Ig_CNNM4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="16">
        <location>
            <begin position="248"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="515"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="850" mass="94170" checksum="FF66A7F880114D3B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Z1</accession>
    <name>A0A5F8H6Z1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Semaphorin-6A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Semaphorin VIA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Semaphorin-6A-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SEMA6A</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Active as a homodimer or oligomer. The SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer. Interacts with EVL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007497909.1">
        <property type="nucleotide sequence ID" value="XM_007497847.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Z1"/>
    <dbReference type="Ensembl" id="ENSMODT00000059602.1">
        <property type="protein sequence ID" value="ENSMODP00000054991.1"/>
        <property type="gene ID" value="ENSMODG00000013614.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100014958"/>
    <dbReference type="CTD" id="57556"/>
    <dbReference type="GeneTree" id="ENSGT00940000156565"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013614">
        <property type="expression patterns" value="Expressed in spinal cord and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11266">
        <property type="entry name" value="Sema_6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000028">
        <property type="entry name" value="semaphorin-6A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000007">
        <property type="entry name" value="semaphorin-6A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF12">
        <property type="entry name" value="SEMAPHORIN-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0732">Signal</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023923222" description="Semaphorin-6A" evidence="22">
        <location>
            <begin position="19"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="23">
        <location>
            <begin position="24"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="805"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="862"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="864"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="881"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="922"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="961"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="973" mass="108118" checksum="CBF99BAB41F08BD2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Z2</accession>
    <name>A0A5F8H6Z2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinetochore associated 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KNTC1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Z2"/>
    <dbReference type="Ensembl" id="ENSMODT00000069386.1">
        <property type="protein sequence ID" value="ENSMODP00000055713.1"/>
        <property type="gene ID" value="ENSMODG00000012292.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007883"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012292">
        <property type="expression patterns" value="Expressed in forelimb bud and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055402">
        <property type="entry name" value="KNTC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019527">
        <property type="entry name" value="RZZ-complex_KNTC1/ROD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24506">
        <property type="entry name" value="KNTC1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10493">
        <property type="entry name" value="Rod_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 N-terminal" evidence="2">
        <location>
            <begin position="187"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="3">
        <location>
            <begin position="364"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="RZZ complex subunit KNTC1/ROD C-terminal" evidence="1">
        <location>
            <begin position="754"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1140" mass="129653" checksum="E928200C431A9CDC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Z3</accession>
    <name>A0A5F8H6Z3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 144</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Z3"/>
    <dbReference type="FunCoup" id="A0A5F8H6Z3">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055755"/>
    <dbReference type="Ensembl" id="ENSMODT00000063216.1">
        <property type="protein sequence ID" value="ENSMODP00000055755.1"/>
        <property type="gene ID" value="ENSMODG00000001956.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100023476"/>
    <dbReference type="CTD" id="55314"/>
    <dbReference type="GeneTree" id="ENSGT00390000012574"/>
    <dbReference type="InParanoid" id="A0A5F8H6Z3"/>
    <dbReference type="OMA" id="FCHFSGI"/>
    <dbReference type="OrthoDB" id="426527at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001956">
        <property type="expression patterns" value="Expressed in spermatocyte and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="365" mass="40182" checksum="6C2B01C500948270" modified="2019-12-11" version="1">MAEQNNNETDLTVGFISSAVAVILFGSNFVPVKKFDTGDGMFLQWILCTAIWTVSLVVNLLLHCPKFWPLAMLGGFIWATGNITVVPIVKTIGLGLGLLIWGSFNSLTGWASSRFGWFGMDPEEVSRPLLNYIGAGLSVIRPDFFPVFPEVFIKYAVIFLFIKSEVPSLTCSLDTTPLLTERAVNSTQTNGLDYSWTKKLSQFQNRLLGCVLAVVSGILYGCSFVPVIYIKDHGKRNDSIYAGSSQYDLDYVFAHFSGIFVTSTVYFLVYCMIMKNNPKVYPQAILPGFFSGVLWALASCCWFIANHSLSAVISFPIITAGPGLIAAMWGIFVFKEIKGIKNYVLITLAFFIILSGALATAFSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Z4</accession>
    <name>A0A5F8H6Z4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Laminin subunit alpha-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Laminin A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Laminin-1 subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Laminin-3 subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">S-laminin subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LAMA1</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000062409.1">
        <property type="protein sequence ID" value="ENSMODP00000055562.1"/>
        <property type="gene ID" value="ENSMODG00000021454.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157124"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021454">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043256">
        <property type="term" value="C:laminin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072359">
        <property type="term" value="P:circulatory system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048732">
        <property type="term" value="P:gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060541">
        <property type="term" value="P:respiratory system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035239">
        <property type="term" value="P:tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000082">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000242">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000454">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000098">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000119">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000033">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000189">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000008">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000017">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000094">
        <property type="entry name" value="Laminin subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000128">
        <property type="entry name" value="laminin subunit alpha-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000407">
        <property type="entry name" value="Laminin subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000065">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010307">
        <property type="entry name" value="Laminin_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF409">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06009">
        <property type="entry name" value="Laminin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 20" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023874795" description="Laminin subunit alpha-1" evidence="22">
        <location>
            <begin position="23"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="26">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="401"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="456"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="591"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="698"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="751"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="800"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="847"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="893"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="939"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="25">
        <location>
            <begin position="1021"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="1252"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="1357"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="23">
        <location>
            <begin position="1617"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="23">
        <location>
            <begin position="1805"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="23">
        <location>
            <begin position="2042"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="1588"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="753"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="893"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="895"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="939"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1271"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1357"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1359"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="1378"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2228" mass="246657" checksum="0894CE458E3170A7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Z5</accession>
    <name>A0A5F8H6Z5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Z5"/>
    <dbReference type="Ensembl" id="ENSMODT00000058159.1">
        <property type="protein sequence ID" value="ENSMODP00000055324.1"/>
        <property type="gene ID" value="ENSMODG00000014545.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164663"/>
    <dbReference type="OMA" id="TETCACW"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014545">
        <property type="expression patterns" value="Expressed in blood and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04981">
        <property type="entry name" value="IgV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001934">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023874217" description="Ig-like domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="140" mass="15240" checksum="4F4EAF11608EEDC1" modified="2019-12-11" version="1">MGFGLNGIFILMILQGVHCDIQLVESGGDVRQPGGSLKLSCKASGFTFSSYYMHWIRQAPGKGLEWVSYISNGAGSSTSYADSVKGRFTISRDNGNSLLHLQMNSLKAEDTATYYCARDTVRERSERADKNLLSASSVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Z6</accession>
    <name>A0A5F8H6Z6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine kinase 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">STK31</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Z6"/>
    <dbReference type="Ensembl" id="ENSMODT00000084303.1">
        <property type="protein sequence ID" value="ENSMODP00000054996.1"/>
        <property type="gene ID" value="ENSMODG00000000777.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007287"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000777">
        <property type="expression patterns" value="Expressed in testis and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20430">
        <property type="entry name" value="Tudor_TDRD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000518">
        <property type="entry name" value="serine/threonine-protein kinase 31 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052451">
        <property type="entry name" value="Ser/Thr_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047383">
        <property type="entry name" value="Tudor_TDRD8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48008">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE IMK3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48008:SF6">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE IMK3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023806922" evidence="2">
        <location>
            <begin position="21"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="60"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="688"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="995" mass="113506" checksum="C4BB4FF11B46A85C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Z7</accession>
    <name>A0A5F8H6Z7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ER membrane associated RNA degradation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ERMARD</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Z7"/>
    <dbReference type="Ensembl" id="ENSMODT00000052271.1">
        <property type="protein sequence ID" value="ENSMODP00000055718.1"/>
        <property type="gene ID" value="ENSMODG00000005645.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001024"/>
    <dbReference type="OMA" id="QRGEVCW"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005645">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025209">
        <property type="entry name" value="DUF4209"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039635">
        <property type="entry name" value="ERMARD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701:SF2">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13910">
        <property type="entry name" value="DUF4209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4209" evidence="2">
        <location>
            <begin position="142"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="629" mass="72682" checksum="CE6A8F1D0D043F8A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6Z9</accession>
    <name>A0A5F8H6Z9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NEK2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_007481415.1">
        <property type="nucleotide sequence ID" value="XM_007481353.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6Z9"/>
    <dbReference type="Ensembl" id="ENSMODT00000064520.1">
        <property type="protein sequence ID" value="ENSMODP00000055567.1"/>
        <property type="gene ID" value="ENSMODG00000002788.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100016325"/>
    <dbReference type="CTD" id="4751"/>
    <dbReference type="GeneTree" id="ENSGT00940000156989"/>
    <dbReference type="OMA" id="LALHRCH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002788">
        <property type="expression patterns" value="Expressed in hindlimb bud and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000151">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000356">
        <property type="entry name" value="Serine/threonine-protein kinase Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="267"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="402" mass="46705" checksum="13629FB25C12A387" modified="2019-12-11" version="1">MTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRSNTTLYIVMEYCEGGDLASVITKCTKERHYSDEDFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRLSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAEKIREGKFRRIPYRYSDELNDIITKMLNLKDYCRPSVEEILENSLIADLVAEEQRKNPERRGRRSGEPEKLQNSGPAMTELKLKELQLQEREKAIKAREERLEQKERELCIRERLAEDKLIRAENLLKNYNLLKEQKILALANSSEPLDFPSSLTKKKVHFSGESKENILSGENSENYPISKSKGCDLKKRLYAAQLRVQALSELEKNYQLKSRQILGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H795</accession>
    <name>A0A5F8H795_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tower domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000067340.1">
        <property type="protein sequence ID" value="ENSMODP00000055419.1"/>
        <property type="gene ID" value="ENSMODG00000009516.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003602"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009516">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04493">
        <property type="entry name" value="BRCA2DBD_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04494">
        <property type="entry name" value="BRCA2DBD_OB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000205">
        <property type="entry name" value="Breast cancer susceptibility protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048262">
        <property type="entry name" value="BRCA2_OB_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015188">
        <property type="entry name" value="BRCA2_OB_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055077">
        <property type="entry name" value="BRCA2_TR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015205">
        <property type="entry name" value="Tower_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09104">
        <property type="entry name" value="BRCA-2_OB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22687">
        <property type="entry name" value="BRCA2_TR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21318">
        <property type="entry name" value="BRCA2DBD_OB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09121">
        <property type="entry name" value="Tower"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002397">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01341">
        <property type="entry name" value="Tower"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81878">
        <property type="entry name" value="BRCA2 tower domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tower" evidence="8">
        <location>
            <begin position="2700"/>
            <end position="2741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1236"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2298"/>
            <end position="2330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2721"/>
            <end position="2748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1252"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2298"/>
            <end position="2315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="3205" mass="361411" checksum="E3553AEA576B025E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H796</accession>
    <name>A0A5F8H796_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CUGBP Elav-like family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CELF2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H796"/>
    <dbReference type="STRING" id="13616.ENSMODP00000055096"/>
    <dbReference type="Ensembl" id="ENSMODT00000056642.1">
        <property type="protein sequence ID" value="ENSMODP00000055096.1"/>
        <property type="gene ID" value="ENSMODG00000016763.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155461"/>
    <dbReference type="InParanoid" id="A0A5F8H796"/>
    <dbReference type="OMA" id="PWKQYFS"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016763">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12634">
        <property type="entry name" value="RRM2_CELF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12638">
        <property type="entry name" value="RRM3_CELF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000015">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000016">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034198">
        <property type="entry name" value="CELF1/2_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034199">
        <property type="entry name" value="CELF1/2_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="63"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="358"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="443" mass="46848" checksum="735EE2D0388B9C80" modified="2019-12-11" version="1">MTGPGSHSQEVSDTRFELRMNLHNPGLALCPLLHLAASIMPEMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKTMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQATSSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATTTNANPLSTTSSALGALTSPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGTINSMAALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H797</accession>
    <name>A0A5F8H797_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pumilio homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PUM1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H797"/>
    <dbReference type="Ensembl" id="ENSMODT00000066772.1">
        <property type="protein sequence ID" value="ENSMODP00000055667.1"/>
        <property type="gene ID" value="ENSMODG00000017067.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158079"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017067">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF1">
        <property type="entry name" value="PUMILIO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PUM-HD" evidence="10">
        <location>
            <begin position="684"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="704"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="740"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="776"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="814"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="850"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="886"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="922"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="961"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="598"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1044" mass="111217" checksum="ED415AC22F4E17C8" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H798</accession>
    <name>A0A5F8H798_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Immunoglobulin like domain containing receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ILDR1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. LISCH7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H798"/>
    <dbReference type="Ensembl" id="ENSMODT00000073803.1">
        <property type="protein sequence ID" value="ENSMODP00000055823.1"/>
        <property type="gene ID" value="ENSMODG00000018288.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183058"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018288">
        <property type="expression patterns" value="Expressed in uterine wall and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051874">
        <property type="entry name" value="Ig-like_domain-LISCH7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008664">
        <property type="entry name" value="LISCH7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15923:SF3">
        <property type="entry name" value="IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15923">
        <property type="entry name" value="TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05624">
        <property type="entry name" value="LSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="8"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="290"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="503" mass="57579" checksum="01DA7491E4B0B1FB" modified="2019-12-11" version="1">MMGPEPPPPLLLLFTWLPAGCLSLLVTVQDTERYVTLFASVVLKCDYTTSAQLQDVVVTWRFKSFCKDPILDYYSASYQAALALGQDPSNDCNDSQRTVRIVAQRRGQNEPVLGVDYRQRKITIQNRADLVINEVMWWDHGVYYCAIEAPGDTAGDPDKEVKLIVLHWLTVIFIILGAILLIVLVSVCWCQCCPQYCCCYVRCPCCPTRCCCPEEDFSPQASFPQMPGPPTPTHPAAANGVLEYLEKELQKLNPAHSLPPDHKARVGRHCSMLSSLGSEIVERRIIHLPPLVRDPPSSQMTSDSSHPQWGPQFSRRPRALEEGQAERRQSHYSNFRQESLEPWPKLKASEHRGRENYKSGRHWTSREEVSHTSWPHSDSLSDDGSYSRDAHWRPNHSTQRSRSPGRRHRPRQRDSSNRLLSHRHRSYSPPSCHSSWSSEEEKERQQQQGWKAHRPPQPPSWSEEKPPSYRSLDVIPGKKVRKRGNEERRSERESSHSGRSVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F6SF89</accession>
    <name>F6SF89_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 35 member F5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLC35F5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Putative solute transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6SF89"/>
    <dbReference type="Ensembl" id="ENSMODT00000037815.3">
        <property type="protein sequence ID" value="ENSMODP00000036226.3"/>
        <property type="gene ID" value="ENSMODG00000000615.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005949"/>
    <dbReference type="HOGENOM" id="CLU_026578_2_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000615">
        <property type="expression patterns" value="Expressed in uterus and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="196"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000036226.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="479" mass="53549" checksum="B639787FEA170F92" modified="2019-12-11" version="3">MVLPRRHGGVGEPGVLKSSACDKLNCAKFSNFSLQDLKKAFKGRQQMVWVFIMNRMNSQSSAFTQRRRMALGIVILLLVDVIWVASSELTSFADAESYFAACTTDNTMNSSLSEPLYVPVKFHDLASEKPERTNGENEKTPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPAVKEQESILKTVGKLTATQVAKISFFFCFVWFLANFSYQEALSDTQVAIVNILSSTSGLFTLILAAVFPSNSGDRFTLSKLLAVILCIGGVVLVNLSGSEKSAGKDTIGSIWSLIGAMLYAVYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEAFEFPNKLVLMCIVINGLIGTVLSELLWLWGCFLTSSLIGTLALSLTIPLTIIADMCLQKVQFSWLFFAGAVPVFFSFFIVTLLCHYNNWDPVMVGVRRIFAFICRKHRIQRVTEDSEQCESLIPLHSVSQEDGTICCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F6THX6</accession>
    <name>F6THX6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 2C23-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100020348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6THX6"/>
    <dbReference type="Ensembl" id="ENSMODT00000004026.4">
        <property type="protein sequence ID" value="ENSMODP00000003940.4"/>
        <property type="gene ID" value="ENSMODG00000002772.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163402"/>
    <dbReference type="HOGENOM" id="CLU_001570_22_3_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002772">
        <property type="expression patterns" value="Expressed in liver and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6THX6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20665">
        <property type="entry name" value="CYP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000176">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF346">
        <property type="entry name" value="CYTOCHROME P450 2C44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000003940.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="476" mass="55320" checksum="944BCC7336274F5A" modified="2019-12-11" version="3">MAILIWNKGYKARRFPPGPIPLPILGNMLQMDSKDLFTFFDKMAEKYGPVFTVYMGLQRIVVLHGYEAVKEALIDQGDNFLNRAQLPIFEDNFKGQGILSSSGEKWRQNRRFSLMTLRNFGMGKRSIEERVQEEAQCLVEELRKTKGQFFDPTFILGCAPCNVICSIVFNNRFNYDDKKFLRLMSLLNENFRLLNTPWIQLYNMYPSLIKRLPGNHRTINKNVLEVRNFIMDEVKKHQETLDPNNPQDYIDCFLIKMQQEKLNPQSAFNYQELMATGSNLFSAGTETTSSTLRYGLLLLMKHPKIQDKVHEEIDRVLGSSRKPSMQDRVKMPYVDAVVHEIQRYIHLLPFSLPRLAAQDIHFQKYVIPKGTSVFPLLYSVLYDRKAFPNPYEFDPENFLDKSGNFQKNDHFVPFSLGKRLCLGESLARMEVFLFLTTILQNFTLKPMVEPKELVTTPLRNGIVNIPSIYKLSLIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>F6THZ2</accession>
    <name>F6THZ2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myocyte enhancer factor 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MEF2A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_001372884.2">
        <property type="nucleotide sequence ID" value="XM_001372847.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056663168.1">
        <property type="nucleotide sequence ID" value="XM_056807190.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056663173.1">
        <property type="nucleotide sequence ID" value="XM_056807195.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056663175.1">
        <property type="nucleotide sequence ID" value="XM_056807197.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056663182.1">
        <property type="nucleotide sequence ID" value="XM_056807204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6THZ2"/>
    <dbReference type="Ensembl" id="ENSMODT00000016212.5">
        <property type="protein sequence ID" value="ENSMODP00000015918.4"/>
        <property type="gene ID" value="ENSMODG00000012725.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100020349"/>
    <dbReference type="KEGG" id="mdo:100020349"/>
    <dbReference type="CTD" id="4205"/>
    <dbReference type="eggNOG" id="KOG0014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156205"/>
    <dbReference type="HOGENOM" id="CLU_022902_4_0_1"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012725">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022102">
        <property type="entry name" value="HJURP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12347">
        <property type="entry name" value="HJURP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="388"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000015918.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="503" mass="54688" checksum="993088AD9916ABCB" modified="2013-01-09" version="2">MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDADDYFEHSPLSEDRFSKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTNHNALTYTNPGSSLVSPSLAASSSLTDTSMLSPPQATMLRNVSPGAPQRPPSTGNTGGMLSTADLTVPNGSGNSPVGNGFVNSRASPNLLVSTGGSNLGKVMPTKSPPPPGNGNLGMNNRKPDLRVVIPPSSKGMMPPLSEEDELELNSQRISSSQSTQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNINIKSEPISPPRDRMTPSGFPQQQQQQQQQQQQQQQQQQQQQQQARQEMGRSPVDSLSSSSSSYDGSDREDPRSDFHSPIGLGRPPNTEDRESPSVKRMRMDTWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F6ULA6</accession>
    <name>F6ULA6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myotubularin related protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MTMR14</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F6ULA6"/>
    <dbReference type="Ensembl" id="ENSMODT00000006075.4">
        <property type="protein sequence ID" value="ENSMODP00000005951.4"/>
        <property type="gene ID" value="ENSMODG00000004830.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQ9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018852"/>
    <dbReference type="HOGENOM" id="CLU_016325_2_0_1"/>
    <dbReference type="OMA" id="CALKTHR"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004830">
        <property type="expression patterns" value="Expressed in ovary and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13213">
        <property type="entry name" value="PH-GRAM_MTMR14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039802">
        <property type="entry name" value="MTMR14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039803">
        <property type="entry name" value="MTMR14_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524:SF2">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000005951.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="597" mass="67184" checksum="730CC92BCD622631" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F6W0E1</accession>
    <name>F6W0E1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trafficking protein particle complex subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRAPPC10</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6W0E1"/>
    <dbReference type="FunCoup" id="F6W0E1">
        <property type="interactions" value="1798"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000026308"/>
    <dbReference type="Ensembl" id="ENSMODT00000026776.4">
        <property type="protein sequence ID" value="ENSMODP00000026308.3"/>
        <property type="gene ID" value="ENSMODG00000021039.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100024973"/>
    <dbReference type="KEGG" id="mdo:100024973"/>
    <dbReference type="CTD" id="7109"/>
    <dbReference type="eggNOG" id="KOG1931">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003873"/>
    <dbReference type="HOGENOM" id="CLU_006893_0_0_1"/>
    <dbReference type="InParanoid" id="F6W0E1"/>
    <dbReference type="OMA" id="TKVHENP"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021039">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056917">
        <property type="entry name" value="Ig_TRAPPC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23604">
        <property type="entry name" value="Ig_TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="5">
        <location>
            <begin position="429"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10 Ig-like" evidence="8">
        <location>
            <begin position="789"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="891"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1190"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1200"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000026308.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1258" mass="142061" checksum="810576FD07B562CC" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F6XUL5</accession>
    <name>F6XUL5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory factor X associated ankyrin containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RFXANK</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6XUL5"/>
    <dbReference type="Ensembl" id="ENSMODT00000008852.4">
        <property type="protein sequence ID" value="ENSMODP00000008681.4"/>
        <property type="gene ID" value="ENSMODG00000007002.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160753"/>
    <dbReference type="HOGENOM" id="CLU_000134_23_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007002">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000031">
        <property type="entry name" value="Ankyrin repeat, family A (RFXANK-like), 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017362">
        <property type="entry name" value="DNA-bd_RFXANK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF4">
        <property type="entry name" value="DNA-BINDING PROTEIN RFXANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038034">
        <property type="entry name" value="DNA-binding_RFXANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000008681.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="272" mass="29372" checksum="F23FBC1D29BD2933" modified="2019-12-11" version="3">MEPEGAVANLTSQGPGQLQEPPILPAFGSQPEDPGQDSSDGSDTVLFHPYPCTPDSGSPDLDGVLTAPHTGSSLKHSTTLTNRQRGNEISALPATLDSLSIHQLAAQGELTQLKEYLLKDAQRSHGDNLVNKPDDRGFTPLIWASAFGEIETVRFLLEWGANPHVLAKERESALSLASTGGYTDIVVMLLERNVDINSYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGHKKVQQVMENHILKLFQNKLLPETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>F6XUM4</accession>
    <name>F6XUM4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">WNK2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="Ensembl" id="ENSMODT00000011214.4">
        <property type="protein sequence ID" value="ENSMODP00000010998.3"/>
        <property type="gene ID" value="ENSMODG00000008832.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100029357"/>
    <dbReference type="KEGG" id="mdo:100029357"/>
    <dbReference type="CTD" id="65268"/>
    <dbReference type="eggNOG" id="KOG0584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157161"/>
    <dbReference type="HOGENOM" id="CLU_000550_3_0_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008832">
        <property type="expression patterns" value="Expressed in heart and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14032">
        <property type="entry name" value="STKc_WNK2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000007">
        <property type="entry name" value="Serine/threonine-protein kinase WNK1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase WNK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000012">
        <property type="entry name" value="Serine/threonine-protein kinase WNK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000494">
        <property type="entry name" value="serine/threonine-protein kinase WNK2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056865">
        <property type="entry name" value="CCTL2_WNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24889">
        <property type="entry name" value="CCTL2_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="247"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="657"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="978"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1152"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1339"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1555"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1806"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1887"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1932"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2058"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2225"/>
            <end position="2258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="997"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1184"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1562"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1577"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1806"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1817"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1906"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1935"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2081"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2231"/>
            <end position="2240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000010998.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2304" mass="247476" checksum="13841C401D07A4A5" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F6YXI5</accession>
    <name>F6YXI5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mesenteric estrogen dependent adiposis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MEDAG</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F6YXI5"/>
    <dbReference type="Ensembl" id="ENSMODT00000011831.4">
        <property type="protein sequence ID" value="ENSMODP00000011611.4"/>
        <property type="gene ID" value="ENSMODG00000009294.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018451"/>
    <dbReference type="HOGENOM" id="CLU_080194_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009294">
        <property type="expression patterns" value="Expressed in ovary and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6YXI5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043460">
        <property type="entry name" value="MEDAG/TEX26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33769:SF3">
        <property type="entry name" value="MESENTERIC ESTROGEN-DEPENDENT ADIPOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33769">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 26 ISOFORM X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011611.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="299" mass="34208" checksum="8B6D69365F114DE5" modified="2019-12-11" version="3">MAVAGCVQLAACSEVEEGSQPTRPSLTSISSGELRSLWTCDCELALLPLQQLLHMQPGFFQLLGDQLLVLGPRTRGGFNVFCDGFVRLDGQLYRVSNYIKRYVELTNYCDYKDYRETILSRPMLFFILVRTEGDTSKEKTYAFLVNTRHPKIRRQIEHGMDTVISSVIGESYRLQFNFQDVVKKFFPPGNEVVNGGDLNFVYEFKADALFDFFYWFGLSNSTVNVNGKILNLSSTSPEKKETIKLFLEKMSEPLIRRSSFSDRKFSVTSRAGDTSWNSYETTMMHVFTPKKGEVLDPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F6YXP4</accession>
    <name>F6YXP4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lactosylceramide alpha-2,3-sialyltransferase</fullName>
            <ecNumber evidence="13">2.4.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ganglioside GM3 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">ST3Gal V</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sialyltransferase 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">ST3GAL5</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1)-Cer (LacCer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM3 (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17950"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60065"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.4.3.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:18418"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a beta-D-Gal-(1&lt;-&gt;1')-ceramide + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41780"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:82643"/>
            <dbReference type="ChEBI" id="CHEBI:143593"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ganglioside GA1 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GM1 (d18:1(4E)/18:0) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73110"/>
            <dbReference type="ChEBI" id="CHEBI:78484"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41785"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ganglioside GA2 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GM2 (d18:1(4E)/18:0) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41776"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78485"/>
            <dbReference type="ChEBI" id="CHEBI:78486"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41777"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.9" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="F6YXP4"/>
    <dbReference type="FunCoup" id="F6YXP4">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000011602"/>
    <dbReference type="Ensembl" id="ENSMODT00000011822.3">
        <property type="protein sequence ID" value="ENSMODP00000011602.3"/>
        <property type="gene ID" value="ENSMODG00000009287.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157929"/>
    <dbReference type="HOGENOM" id="CLU_032020_3_2_1"/>
    <dbReference type="InParanoid" id="F6YXP4"/>
    <dbReference type="OMA" id="MHYVDPE"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009287">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047291">
        <property type="term" value="F:lactosylceramide alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23983">
        <property type="entry name" value="GT29_ST3GAL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000006">
        <property type="entry name" value="ST3 beta-galactoside alpha-2,3-sialyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051142">
        <property type="entry name" value="Glycosyltransferase_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713:SF60">
        <property type="entry name" value="LACTOSYLCERAMIDE ALPHA-2,3-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713">
        <property type="entry name" value="SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="24">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011602.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="497" mass="55906" checksum="2D116CF6F9696872" modified="2019-12-11" version="2">MRGEGGRGGTGGGAAAARARLSVATRPWPPTRAETGSSVGPCPAGGQGRCARAERARTLPNFIMRKQARGQGGGGRVERSPQQPIWEPAPTPASAREEAVAPTPADRAMPTEHNYLKLKSDCPPILPCYVPPPKKMRRFNLLLKDFLKCFLIVFGVWILYILKLNFTTEECDMKGAHHVDPKRVKRAQNYARQVLQGECRPDFAKKEMHRLFAQQYDVNASPFINENMELEEDLYRYDPPFGFRKFSYKLQSLLKLLPEHGLPENLKAKPCKHCVVMGNGGVLNGLGLGHILNQFDVVIRLNSAPVQGYTDHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVTVLFKSVDFNWLEAMLKNETMPLWVQLFFWKHVAEKIPLQSKQFRILNPVIIKNTAIDMLHYSEPQPRIWGWSKNVPTMGVVAVVLATHLCDEVSLAGFGYDLSRPKTPLHYFDNLCMAAMNIQTMHNLTTETRFLQKLVKEGIVKDLSGGIHCEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>F7ALC5</accession>
    <name>F7ALC5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein Sec31A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">SEC31-like protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">SEC31-related protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SEC31A</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13. Interacts with PDCD6; interaction takes place in response to cytosolic calcium increase and leads to bridge together the BCR(KLHL12) complex and SEC31A, leading to monoubiquitination. Interacts with KLHL12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7ALC5"/>
    <dbReference type="Ensembl" id="ENSMODT00000015376.4">
        <property type="protein sequence ID" value="ENSMODP00000015096.4"/>
        <property type="gene ID" value="ENSMODG00000012053.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003175"/>
    <dbReference type="HOGENOM" id="CLU_003033_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012053">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000001">
        <property type="entry name" value="Protein transport protein Sec31A isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000009">
        <property type="entry name" value="Protein transport protein Sec31A isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000001">
        <property type="entry name" value="protein transport protein Sec31A isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF23">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC31A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 18" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="20">
        <location>
            <begin position="582"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="797"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="983"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1054"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000015096.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1248" mass="136123" checksum="7F8EF81FFDEE0506" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F7D3B9</accession>
    <name>F7D3B9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ELMO domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ELMOD1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F7D3B9"/>
    <dbReference type="FunCoup" id="F7D3B9">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000018382"/>
    <dbReference type="Ensembl" id="ENSMODT00000018715.3">
        <property type="protein sequence ID" value="ENSMODP00000018382.2"/>
        <property type="gene ID" value="ENSMODG00000014705.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100032515"/>
    <dbReference type="KEGG" id="mdo:100032515"/>
    <dbReference type="CTD" id="55531"/>
    <dbReference type="eggNOG" id="KOG2998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159782"/>
    <dbReference type="HOGENOM" id="CLU_056289_0_0_1"/>
    <dbReference type="InParanoid" id="F7D3B9"/>
    <dbReference type="OMA" id="PHFQQTF"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014705">
        <property type="expression patterns" value="Expressed in spinal cord and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF18">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="133"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000018382.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="334" mass="39028" checksum="8C7CF03E472D561A" modified="2013-01-09" version="2">MKHFLRMLIQVCVYFYCKCLWRCMKFVVRKLTGRCELQRICYNNKPGAGRTMKIESSLRDSKSKLLQTSVSVHPDAIEKTVDDIMELKKINPDINPQLGISLQACLLQIVGYRNLIAEVEKLRREPYDSDNPQHEEMLLKLWKSLKPDTPLEARISKQWCEIGFQGDDPKTDFRGMGLLGLYNLEYFAEWDVVTAQQVLSDSLHPKYREVTKEEISKFSKAEWEKKRLDKAIGYSFAIVGINITDLAYNLLISGALKTHFYNVAPEAPTLSHFQQTFCYLMHEFHKFWIEEDPMDIMEFNRVREKFRKRILKQLQNPDMALCPHFAASEGLINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F7DUG6</accession>
    <name>F7DUG6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PHD finger protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PHF20</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7DUG6"/>
    <dbReference type="Ensembl" id="ENSMODT00000032434.3">
        <property type="protein sequence ID" value="ENSMODP00000030863.3"/>
        <property type="gene ID" value="ENSMODG00000001533.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156477"/>
    <dbReference type="HOGENOM" id="CLU_032484_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001533">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7DUG6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20104">
        <property type="entry name" value="MBT_PHF20L1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20453">
        <property type="entry name" value="Tudor_PHF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000043">
        <property type="entry name" value="PHD finger protein 20 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000049">
        <property type="entry name" value="PHD finger protein 20 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000196">
        <property type="entry name" value="PHD finger protein 20 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043449">
        <property type="entry name" value="PHF20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022255">
        <property type="entry name" value="PHF20_AT-hook"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856:SF27">
        <property type="entry name" value="PHD FINGER PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856">
        <property type="entry name" value="PHD FINGER PROTEIN 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12618">
        <property type="entry name" value="PHF20_AT-hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="156"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="351"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="409"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000030863.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="870" mass="100997" checksum="C2F98AF9F9CD4464" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F7EY06</accession>
    <name>F7EY06_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC103093231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="RefSeq" id="XP_007472982.1">
        <property type="nucleotide sequence ID" value="XM_007472920.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7EY06"/>
    <dbReference type="Ensembl" id="ENSMODT00000009251.4">
        <property type="protein sequence ID" value="ENSMODP00000009071.4"/>
        <property type="gene ID" value="ENSMODG00000007310.4"/>
    </dbReference>
    <dbReference type="GeneID" id="103093231"/>
    <dbReference type="eggNOG" id="KOG0324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164487"/>
    <dbReference type="HOGENOM" id="CLU_1299368_0_0_1"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007310">
        <property type="expression patterns" value="Expressed in brain and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF41">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="7">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000009071.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="187" mass="20873" checksum="25865BB0FB916329" modified="2019-12-11" version="3">MSRSVRRNLGYWINEYTSTLGIGVFHSGIEIYGREFAYGGHPYPFSGIFEITPGSAVELGETFKFKEAIALGTTDFTEEDVDKILEELGKEYKGNAYHLMHKNCNHFSDALAEILCGREIPRWVNRLAYFSSCIPFLQSCLPKEWLTPAALQTHIGLGLRKEDSGSAADEEVPSTSGASRTCKHTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F7F9H4</accession>
    <name>F7F9H4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IKBKB interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IKBIP</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007503320.1">
        <property type="nucleotide sequence ID" value="XM_007503258.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7F9H4"/>
    <dbReference type="Ensembl" id="ENSMODT00000009751.4">
        <property type="protein sequence ID" value="ENSMODP00000009562.4"/>
        <property type="gene ID" value="ENSMODG00000007700.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100019061"/>
    <dbReference type="CTD" id="121457"/>
    <dbReference type="eggNOG" id="ENOG502RXC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000045001"/>
    <dbReference type="HOGENOM" id="CLU_979896_0_0_1"/>
    <dbReference type="OMA" id="KKCESVQ"/>
    <dbReference type="OrthoDB" id="9907187at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007700">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024152">
        <property type="entry name" value="Inh_kappa-B_kinase-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21734">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21734:SF10">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000009562.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="391" mass="42708" checksum="FF735B7012FBB988" modified="2019-12-11" version="3">MPAAHPGLVTVSGRPCPPPGPAEMSEAKHRKKAGVKGAPPEPGRRGESGQPPEPARVSGDGGGGGGGGGGGGGGGGGGGGWADPRTVLCLLSLGTSLALAWFVFQQSEKFDNVENKYQLLKLEAAEFHSLQSQVTLISEKCQKSEAMIKQLKDFQIIAHLKRLQEDVYNLKTWSNRITEKRDKLNNNMTALYQAVTNTDQSTSFLAKEVSLKISAVKTDIRRISGLVTDVTSLTESVQDLESKLEKAEQNTVKSIGDLLSSSIDRTAKLRSLASENSERIQVANKMLSELDSDFSKHSDRLLNLESDRAKILKTVNFANDLKPKVYNLKKDFSRLEPMINDLTLRIGRLVADLLQREKEIAFLNEKISNITIVQTEIKDVKEEITKISDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F7F9J6</accession>
    <name>F7F9J6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carcinoembryonic antigen-related cell adhesion molecule 6-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the immunoglobulin superfamily. CEA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7F9J6"/>
    <dbReference type="Ensembl" id="ENSMODT00000012100.3">
        <property type="protein sequence ID" value="ENSMODP00000011877.2"/>
        <property type="gene ID" value="ENSMODG00000009507.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RXPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263479"/>
    <dbReference type="HOGENOM" id="CLU_019260_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009507">
        <property type="expression patterns" value="Expressed in spermatid and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000244">
        <property type="entry name" value="carcinoembryonic antigen-related cell adhesion molecule 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="369"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="460"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011877.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="586" mass="66207" checksum="9F658EFA6E9A927A" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F7F9M2</accession>
    <name>F7F9M2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED24</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7F9M2"/>
    <dbReference type="Ensembl" id="ENSMODT00000024272.3">
        <property type="protein sequence ID" value="ENSMODP00000023848.4"/>
        <property type="gene ID" value="ENSMODG00000013011.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPJD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016438"/>
    <dbReference type="HOGENOM" id="CLU_1021341_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013011">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7F9M2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021429">
        <property type="entry name" value="Mediator_Med24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12898">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12898:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11277">
        <property type="entry name" value="Med24_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000023848.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="975" mass="109128" checksum="4F2794E5D37C38CD" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F7F9M8</accession>
    <name>F7F9M8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vitamin D-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Gc-globulin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Group-specific component</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GC</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Interacts with LRP2; the interaction is required for renal uptake of GC in complex with 25-hydroxyvitamin D3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7F9M8"/>
    <dbReference type="Ensembl" id="ENSMODT00000024270.4">
        <property type="protein sequence ID" value="ENSMODP00000023846.4"/>
        <property type="gene ID" value="ENSMODG00000019105.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTPW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000113"/>
    <dbReference type="HOGENOM" id="CLU_045992_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019105">
        <property type="expression patterns" value="Expressed in liver and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005499">
        <property type="term" value="F:vitamin D binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00015">
        <property type="entry name" value="ALBUMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000264">
        <property type="entry name" value="ALB/AFP/VDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020858">
        <property type="entry name" value="Serum_albumin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014760">
        <property type="entry name" value="Serum_albumin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000213">
        <property type="entry name" value="VitD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015247">
        <property type="entry name" value="VitD-bind_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11385">
        <property type="entry name" value="SERUM ALBUMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11385:SF11">
        <property type="entry name" value="VITAMIN D-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00273">
        <property type="entry name" value="Serum_albumin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09164">
        <property type="entry name" value="VitD-bind_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00802">
        <property type="entry name" value="SERUMALBUMIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00804">
        <property type="entry name" value="VITAMNDBNDNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00103">
        <property type="entry name" value="ALBUMIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48552">
        <property type="entry name" value="Serum albumin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51438">
        <property type="entry name" value="ALBUMIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0848">Vitamin D</keyword>
    <feature type="domain" description="Albumin" evidence="14">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Albumin" evidence="14">
        <location>
            <begin position="209"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000023846.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="485" mass="55188" checksum="5524CCD91F907A53" modified="2019-12-11" version="3">MCCTTIIKMGICTDSLVSVFVGRDYEKSKVCKEFANLGKDNFQSLSFVLYSKKFSRGTFEEIKALVDEVVSLTEECCDVNAAPDCYDRRTTELSSKSCEHDAPFPKHPDTHKCCAQEGLERKLCMAALVHPPQEFPTYKESSNEEICESFRKNPRDFAEKFLHKFSSSYGQAPLPLLVSYTKNYLSMVSTCCASSDITACFAKETFQNKYLTLLTILSDRVCSAFTIYGMEKTRFSYIVKFSQKAPAANLEDVIKVAESMTNVLSKCCDSIMEDCMSKEITEYTVSACEHLSDKEKEFKNCCGEKNPLDIFLCTYSMPAAQPIKLPDIVKPTNEEICNTENTNAIDRYTYEISRRNPYIPEVFITKVHSLSKEVLSECCKAVEPQACLKSQRPLARSEITSFLAKAEELCGDYSQLTFTEFKKRLTQHFKTNFPKANSKNIKDMVENRTDFAFKCCQMNSPPLYCDQKEDDQKARDEIQSLKIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3T3</accession>
    <name>A0A5F8G3T3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Multidrug resistance-associated protein 1</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
            <ecNumber evidence="15">7.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">ATP-binding cassette sub-family C member 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Glutathione-S-conjugate-translocating ATPase ABCC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Leukotriene C(4) transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">ABCC1</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82961"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:60129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:74887"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143093"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione(in) + ATP + H2O = S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81611"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:156326"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:81612"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33147"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64677"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:33148"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>prostaglandin A2-S-(R)-glutathione(in) + ATP + H2O = prostaglandin A2-S-(R)-glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81695"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:133768"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:81696"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>prostaglandin A2-S-(S)-glutathione(in) + ATP + H2O = prostaglandin A2-S-(S)-glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:133769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:81700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38951"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60119"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:38952"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>vincristine(in) + ATP + H2O = vincristine(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60160"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143658"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:60161"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EC" id="7.6.2.3" evidence="15"/>
    <dbReference type="Ensembl" id="ENSMODT00000054629.1">
        <property type="protein sequence ID" value="ENSMODP00000042129.1"/>
        <property type="gene ID" value="ENSMODG00000004194.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160271"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004194">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000293">
        <property type="entry name" value="ATP binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000007">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005292">
        <property type="entry name" value="MRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF241">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 30" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="532"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="1058"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="32">
        <location>
            <begin position="322"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="31">
        <location>
            <begin position="624"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="32">
        <location>
            <begin position="941"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="31">
        <location>
            <begin position="1261"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1499" mass="168975" checksum="649391686D03B283" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3T4</accession>
    <name>A0A5F8G3T4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-acyl-ADP-ribose deacylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">OARD1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3T4"/>
    <dbReference type="Ensembl" id="ENSMODT00000083020.1">
        <property type="protein sequence ID" value="ENSMODP00000042096.1"/>
        <property type="gene ID" value="ENSMODG00000040747.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006988"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000040747">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050892">
        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="77" mass="8445" checksum="4519E7B6B37987A3" modified="2019-12-11" version="1">MANSPDEDPGENRIVYVKGDLFACPQTDSLAHCISEDCRMGAGIAVLFKKKFGGVQELLNQRLDVVLIAYSGRKCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3T6</accession>
    <name>A0A5F8G3T6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="22">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">INSRR</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="22"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3T6"/>
    <dbReference type="Ensembl" id="ENSMODT00000082328.1">
        <property type="protein sequence ID" value="ENSMODP00000042143.1"/>
        <property type="gene ID" value="ENSMODG00000016712.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160437"/>
    <dbReference type="OMA" id="IQRGHVY"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016712">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05032">
        <property type="entry name" value="PTKc_InsR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000050">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000014">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000087">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000108">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000026">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000001">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000002">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016246">
        <property type="entry name" value="Tyr_kinase_insulin-like_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF338">
        <property type="entry name" value="INSULIN RECEPTOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000620">
        <property type="entry name" value="Insulin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 22" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="470"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="787"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="927"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="19">
        <location>
            <position position="1063"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="937"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20 21">
        <location>
            <position position="961"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="1008"/>
            <end position="1014"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="1067"/>
            <end position="1068"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1081"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000620-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000620-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1248" mass="138831" checksum="DD7219289A0E048B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3T8</accession>
    <name>A0A5F8G3T8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TCDD inducible poly(ADP-ribose) polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TIPARP</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3T8"/>
    <dbReference type="Ensembl" id="ENSMODT00000068180.1">
        <property type="protein sequence ID" value="ENSMODP00000042134.1"/>
        <property type="gene ID" value="ENSMODG00000015744.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155368"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015744">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000003">
        <property type="entry name" value="TCDD-inducible poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF7">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE TIPARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="12">
        <location>
            <begin position="402"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="610" mass="69217" checksum="6A192B1BD36CEB38" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3U1</accession>
    <name>A0A5F8G3U1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3U1"/>
    <dbReference type="Ensembl" id="ENSMODT00000069441.1">
        <property type="protein sequence ID" value="ENSMODP00000042080.1"/>
        <property type="gene ID" value="ENSMODG00000002507.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182879"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002507">
        <property type="expression patterns" value="Expressed in liver and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF177">
        <property type="entry name" value="CYTOCHROME P450 2J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="169" mass="18843" checksum="C2BFED708483CCAE" modified="2019-12-11" version="1">MQLGNVLPSLQTLLLFSAILLILASYGQRRRQDPNYPPGPPQMPIFGNIFQIDSKNPHISIQEVRSLLGTPMIVVTGLPLIKEVLVNQGHLFVDRPRAPSQSYIFKINGKKKPGSQCHCLFASNGQEWKDQRRFTLMTLRNFGLGKKTLELQIQKELCIGGGECGGKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3U3</accession>
    <name>A0A5F8G3U3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein axonemal intermediate chain 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DNAI7</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNAI7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007503575.1">
        <property type="nucleotide sequence ID" value="XM_007503513.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3U3"/>
    <dbReference type="Ensembl" id="ENSMODT00000052836.1">
        <property type="protein sequence ID" value="ENSMODP00000042122.1"/>
        <property type="gene ID" value="ENSMODG00000017466.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100010211"/>
    <dbReference type="CTD" id="55259"/>
    <dbReference type="GeneTree" id="ENSGT00390000004708"/>
    <dbReference type="OrthoDB" id="297923at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017466">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031826">
        <property type="entry name" value="IC97/Casc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023247">
        <property type="entry name" value="IC97/Dnai7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15927">
        <property type="entry name" value="Casc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02043">
        <property type="entry name" value="CANCERSCCP1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IC97/Casc1 N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="746" mass="86213" checksum="5EC9533E6B6A2115" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G3U9</accession>
    <name>A0A5F8G3U9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UBE3C</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G3U9"/>
    <dbReference type="Ensembl" id="ENSMODT00000052670.1">
        <property type="protein sequence ID" value="ENSMODP00000042144.1"/>
        <property type="gene ID" value="ENSMODG00000005239.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156321"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005239">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000014">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="745"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1021" mass="117078" checksum="03720FED68D38323" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G453</accession>
    <name>A0A5F8G453_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CAP-Gly domain containing linker protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLIP1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G453"/>
    <dbReference type="Ensembl" id="ENSMODT00000059264.1">
        <property type="protein sequence ID" value="ENSMODP00000042224.1"/>
        <property type="gene ID" value="ENSMODG00000012253.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155122"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012253">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLIP1 zinc knuckle" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CLIP1 zinc knuckle" evidence="8">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="115" mass="13459" checksum="B80A808486C6AF98" modified="2019-12-11" version="1">MIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNDLHNYDSDDQEKQFKKKPRLFCDICDCFDLHDTEDCPTQTQVPEDPPHSTHHGSRSEERPYCEICEMFGHWATNCNDDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G457</accession>
    <name>A0A5F8G457_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">54 kDa nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NUP54</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUP58. Interacts with NUTF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NUP54 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G457"/>
    <dbReference type="FunCoup" id="A0A5F8G457">
        <property type="interactions" value="2910"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042229"/>
    <dbReference type="Ensembl" id="ENSMODT00000073782.1">
        <property type="protein sequence ID" value="ENSMODP00000042229.1"/>
        <property type="gene ID" value="ENSMODG00000019296.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013620"/>
    <dbReference type="InParanoid" id="A0A5F8G457"/>
    <dbReference type="OMA" id="MMQTRLH"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019296">
        <property type="expression patterns" value="Expressed in spermatid and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000003">
        <property type="entry name" value="nucleoporin p54 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000034">
        <property type="entry name" value="Nucleoporin P54, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040985">
        <property type="entry name" value="Nup54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18437">
        <property type="entry name" value="Nup54_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="17">
        <location>
            <begin position="351"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Nup54 C-terminal interacting" evidence="18">
        <location>
            <begin position="504"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="558" mass="60422" checksum="4D20C1931C7286D6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G458</accession>
    <name>A0A5F8G458_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tubulin folding cofactor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TBCB</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G458"/>
    <dbReference type="Ensembl" id="ENSMODT00000060399.1">
        <property type="protein sequence ID" value="ENSMODP00000042238.1"/>
        <property type="gene ID" value="ENSMODG00000014175.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156119"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014175">
        <property type="expression patterns" value="Expressed in spinal cord and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="60" mass="6561" checksum="0A76D3580D0CF13D" modified="2019-12-11" version="1">MDLELYGVDDSFCMKLDQDDALLGSYPVDDGCRIHDSQISSLDTGLVSAMMNPWGSMMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G459</accession>
    <name>A0A5F8G459_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Phosphodiesterase</fullName>
            <ecNumber evidence="22">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PDE10A</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3',5'-cyclic GMP + H2O = GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16957"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14653"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57867"/>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
            <dbReference type="EC" id="3.1.4.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="22">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="16">Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="22"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G459"/>
    <dbReference type="Ensembl" id="ENSMODT00000063557.1">
        <property type="protein sequence ID" value="ENSMODP00000042241.1"/>
        <property type="gene ID" value="ENSMODG00000006355.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156543"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006355">
        <property type="expression patterns" value="Expressed in spermatocyte and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000005">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000011">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000007">
        <property type="entry name" value="Phosphodiesterase 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="15" id="KW-0114">cAMP</keyword>
    <keyword evidence="9" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="8" id="KW-0140">cGMP</keyword>
    <keyword evidence="14" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDEase" evidence="23">
        <location>
            <begin position="396"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="19">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="469"/>
            <end position="473"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="738" mass="84614" checksum="EAE517B4E4FF7A4E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G461</accession>
    <name>A0A5F8G461_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">REEP4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G461"/>
    <dbReference type="FunCoup" id="A0A5F8G461">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042234"/>
    <dbReference type="Ensembl" id="ENSMODT00000080812.1">
        <property type="protein sequence ID" value="ENSMODP00000042234.1"/>
        <property type="gene ID" value="ENSMODG00000009592.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161674"/>
    <dbReference type="InParanoid" id="A0A5F8G461"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009592">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007084">
        <property type="term" value="P:mitotic nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF36">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="269" mass="30820" checksum="1A166DD9C81BC7C4" modified="2019-12-11" version="1">MSLHRGNAAGPASSWNVSTTWASREGRGEAEQPLPDPITPRLHPNQVRWMMYWIVFAFFMTVETFTDIFISWFPFYYEIKIAFVVWLLSPYTKGASLLYRKFVHPALSYREKEIDSYIVKAKERSYETVLSFGKRGLNIAATAAVQAAAKSQGALAGRLRSFSMQDLRSIPDNPAPPYQDPLYLEDQELHRRPPIRYRPGGLQDSDTEDECWSDSQTKAHTLPRPREKPLVRSQSLRIGKRKPLVRESTSRSMKVRTRKKAVAPVELDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G462</accession>
    <name>A0A5F8G462_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G462"/>
    <dbReference type="Ensembl" id="ENSMODT00000058259.1">
        <property type="protein sequence ID" value="ENSMODP00000042246.1"/>
        <property type="gene ID" value="ENSMODG00000009082.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157272"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009082">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15732">
        <property type="entry name" value="FYVE_MTMR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13341">
        <property type="entry name" value="PH-GRAM_MTMR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14586">
        <property type="entry name" value="PTP-MTMR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000073">
        <property type="entry name" value="myotubularin-related protein 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035888">
        <property type="entry name" value="MTMR3_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046352">
        <property type="entry name" value="MTMR3_PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF66">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="17">
        <location>
            <begin position="155"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="16">
        <location>
            <begin position="1067"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="616"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="695"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="979"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1020"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="696"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="351"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="413"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1155" mass="128439" checksum="769DDE031D57D239" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G469</accession>
    <name>A0A5F8G469_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Coiled-coil-helix-coiled-coil-helix domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CHCHD3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G469"/>
    <dbReference type="Ensembl" id="ENSMODT00000079030.1">
        <property type="protein sequence ID" value="ENSMODP00000042220.1"/>
        <property type="gene ID" value="ENSMODG00000014416.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000903"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014416">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007964">
        <property type="entry name" value="MIC19/MIC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052632">
        <property type="entry name" value="MICOS_subunit_Mic19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21588">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21588:SF18">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05300">
        <property type="entry name" value="MIC19_MIC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="222" mass="25460" checksum="611423E9A463C33B" modified="2019-12-11" version="1">MGGTSSTRRVTFETDENENITVVKGIRLSENVIGRMKESSPSGPKSPTRSRSYDSKVNEEGIRRRVAEEMAMKDSESQKSRAKHGKIQAREDINKLLERERSITNEQLTRAILLERASSEEEKSKVKHLAKQLEEKDRVLKKQDAFYKEQLARLEERSAEFYKVTTEQYQRAADEVESKFRALEQDKVIKAGCQYIITISLLCKLHAQMLLFSASGFTDLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4T4</accession>
    <name>A0A5F8G4T4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Katanin catalytic subunit A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">KATNA1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4T4"/>
    <dbReference type="Ensembl" id="ENSMODT00000082423.1">
        <property type="protein sequence ID" value="ENSMODP00000042488.1"/>
        <property type="gene ID" value="ENSMODG00000016819.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156638"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016819">
        <property type="expression patterns" value="Expressed in blood and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21748">
        <property type="entry name" value="Kp60-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000003">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000159">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048611">
        <property type="entry name" value="KATNA1_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF71">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21126">
        <property type="entry name" value="KATNA1_MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="167"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="97"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="313" mass="35488" checksum="F6532A2C67A092F6" modified="2019-12-11" version="1">MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEISVEAKHVKDIMKTLESFKLDSTPLKAAHQELPASEGEVWSLPVPVERRPSPGPRKRQSPQYSDSRLHGNRPSAAVKVPHRPSSQNSNNDKGKSVRCREKKEQQNKGREEKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSEMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4U0</accession>
    <name>A0A5F8G4U0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proton-coupled amino acid transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100024692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4U0"/>
    <dbReference type="FunCoup" id="A0A5F8G4U0">
        <property type="interactions" value="851"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042459"/>
    <dbReference type="Ensembl" id="ENSMODT00000082080.1">
        <property type="protein sequence ID" value="ENSMODP00000042459.1"/>
        <property type="gene ID" value="ENSMODG00000009087.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156583"/>
    <dbReference type="InParanoid" id="A0A5F8G4U0"/>
    <dbReference type="OMA" id="YNPQVKW"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009087">
        <property type="expression patterns" value="Expressed in endometrium and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF188">
        <property type="entry name" value="PROTON-COUPLED AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="78"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="508" mass="56055" checksum="C8BE07FEAF935E31" modified="2019-12-11" version="1">MDSPTQEPTKGVELKVMAPEGLNSAPIPPATMSTQRLRNEDYNDYSSTEVSPTETPSNGLDNFSNSSSYQRFGEVNGTTRLQTLIHLLKGNIGTGLLGLPLAVKNAGILLGPLSLIVMGIVATHCMGILVKCAHHFCRRLHKPFLDYGDTVMYGLEASPSSWLRTHSLWGRRIVSFFLVVTQLGFCSVYFVFMADNFKQVVEAANGTTNNCHNNETVLPIPTMDSRLYMLTFLPFVVLLVFIRNLKALTLISVLANITMLASLIMIYQHIVQGIPDPRNLPLAANWKTYPLFFGTAIFAFEGIGVVLPLENKMKDPRHFPGILYLGMTIITLLYITLGSLGYLQYGAAIQGSITLNLPNCWLYQSVKLLYSIGIFFTYSLQFYVPAEIINPFFVSRVTERWALVVDLSVRIVMASLTCALAILIPRLDLVISLVGSVSSSALALIIPPLLDITTYYSEGMSPIIITKDILISLFGFVGFVVGTYQAIYELIQPNVSPTFSNVTSAFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4U1</accession>
    <name>A0A5F8G4U1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain containing 178</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4U1"/>
    <dbReference type="Ensembl" id="ENSMODT00000075401.1">
        <property type="protein sequence ID" value="ENSMODP00000042467.1"/>
        <property type="gene ID" value="ENSMODG00000028160.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166855"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000028160">
        <property type="expression patterns" value="Expressed in spermatocyte and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038826">
        <property type="entry name" value="CCDC178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35088">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35088:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="88132" checksum="22386A279C6B0153" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4U2</accession>
    <name>A0A5F8G4U2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Receptor-type tyrosine-protein phosphatase U</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Pancreatic carcinoma phosphatase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Receptor-type protein-tyrosine phosphatase psi</fullName>
        </alternativeName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Forms homooligomeric complexes which mediate cell homotypic adhesion. Interacts (via the cytoplasmic juxtamembrane domain) with CTNNB1; may mediate interaction with the cadherin/catenin adhesion complex. Interacts with KIT. May interact with AP3B1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4U2"/>
    <dbReference type="Ensembl" id="ENSMODT00000079360.1">
        <property type="protein sequence ID" value="ENSMODP00000042451.1"/>
        <property type="gene ID" value="ENSMODG00000011076.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157151"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011076">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000019">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase kappa isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000009">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000048">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000022">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000025">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF10">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE U-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00740">
        <property type="entry name" value="MAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="13" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="15 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="27">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
            <begin position="170"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="29">
        <location>
            <begin position="268"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="29">
        <location>
            <begin position="366"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="29">
        <location>
            <begin position="465"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00054617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00063907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00073602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00076349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="786" mass="87409" checksum="BD5E815AF8C9073E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4U3</accession>
    <name>A0A5F8G4U3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Regulating synaptic membrane exocytosis 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RIMS1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056674456.1">
        <property type="nucleotide sequence ID" value="XM_056818478.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000062044.1">
        <property type="protein sequence ID" value="ENSMODP00000042498.1"/>
        <property type="gene ID" value="ENSMODG00000018557.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021074"/>
    <dbReference type="CTD" id="22999"/>
    <dbReference type="GeneTree" id="ENSGT00940000155134"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018557">
        <property type="expression patterns" value="Expressed in cerebellum and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04031">
        <property type="entry name" value="C2A_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04028">
        <property type="entry name" value="C2B_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06714">
        <property type="entry name" value="PDZ_RIM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000546">
        <property type="entry name" value="Regulating synaptic membrane exocytosis 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000001">
        <property type="entry name" value="Regulating synaptic membrane exocytosis 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000003">
        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000003">
        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054386">
        <property type="entry name" value="RIM_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF18">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22601">
        <property type="entry name" value="RIM2a_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RabBD" evidence="14">
        <location>
            <begin position="24"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="13">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="607"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="744"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="1396"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="700"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="872"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1190"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1267"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1203"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1335"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1550" mass="173772" checksum="BFA866E88A79BA92" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4U4</accession>
    <name>A0A5F8G4U4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="3">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PYCR1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:14107"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:14111"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4U4"/>
    <dbReference type="Ensembl" id="ENSMODT00000069911.1">
        <property type="protein sequence ID" value="ENSMODP00000042465.1"/>
        <property type="gene ID" value="ENSMODG00000003122.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183044"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003122">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000064">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF6">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="12">
        <location>
            <begin position="181"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="6"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="289" mass="30510" checksum="F6EC42C735294C7D" modified="2019-12-11" version="1">MSVGFIGAGQLAFALAKGFTSAGILASHKIMASSPAMDLPTVSALRKIGVNLTPNNKETVHHSDVLFLAVKPHIIPFILDEIAADIEDRHIIVSCAAGVTINSIEKKLTAFQPAPKVIRCMTNTPVIVREGATVYATGTHAQVEDGKLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAYGAAKMLLESEQHPGQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAAIKKTLLDKVKLDSPTVSTKSSPNLVKLLVHSQAPGGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4U6</accession>
    <name>A0A5F8G4U6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Angiopoietin-1 receptor</fullName>
            <ecNumber evidence="5">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Endothelial tyrosine kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="32">Tyrosine kinase with Ig and EGF homology domains-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Tyrosine-protein kinase receptor TIE-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="44" type="primary">TEK</name>
    </gene>
    <organism evidence="44 45">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="44 45" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="44" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="44" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="36">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4U6"/>
    <dbReference type="Ensembl" id="ENSMODT00000055058.1">
        <property type="protein sequence ID" value="ENSMODP00000042464.1"/>
        <property type="gene ID" value="ENSMODG00000004269.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158840"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004269">
        <property type="expression patterns" value="Expressed in lung and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031589">
        <property type="term" value="P:cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045785">
        <property type="term" value="P:positive regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045765">
        <property type="term" value="P:regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000351">
        <property type="term" value="P:regulation of endothelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001936">
        <property type="term" value="P:regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05088">
        <property type="entry name" value="PTKc_Tie2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000407">
        <property type="entry name" value="angiopoietin-1 receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000406">
        <property type="entry name" value="angiopoietin-1 receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000113">
        <property type="entry name" value="Putative tyrosine-protein kinase receptor Tie-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000388">
        <property type="entry name" value="TEK receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000391">
        <property type="entry name" value="TEK receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000441">
        <property type="entry name" value="TEK receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000123">
        <property type="entry name" value="Tyrosine-protein kinase receptor Tie-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018941">
        <property type="entry name" value="Tyr_kin_Tie2_Ig-like_dom-1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF125">
        <property type="entry name" value="ANGIOPOIETIN-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10430">
        <property type="entry name" value="Ig_Tie2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17 34 37" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="26" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="23 36" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 36" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="25" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="27" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="35" id="KW-0460">Magnesium</keyword>
    <keyword evidence="21 38" id="KW-0472">Membrane</keyword>
    <keyword evidence="35" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 34 37" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-0675">Receptor</keyword>
    <keyword evidence="45" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="13 39" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 38" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20 38" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="22" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="18" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="39">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023919864" description="Angiopoietin-1 receptor" evidence="39">
        <location>
            <begin position="23"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="38">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="41">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="42">
        <location>
            <begin position="262"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="43">
        <location>
            <begin position="355"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="43">
        <location>
            <begin position="456"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="43">
        <location>
            <begin position="553"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="40">
        <location>
            <begin position="736"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="33">
        <location>
            <position position="876"/>
        </location>
    </feature>
    <feature type="binding site" evidence="34">
        <location>
            <begin position="743"/>
            <end position="750"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="34 37">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="34">
        <location>
            <position position="880"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="35">
        <location>
            <position position="881"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="35">
        <location>
            <position position="894"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="36">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00072791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00075340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00078633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00082816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="40">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="41">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="42">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1036" mass="116257" checksum="D661D433233C0C25" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4U7</accession>
    <name>A0A5F8G4U7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trinucleotide repeat-containing gene 6C protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TNRC6C</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GW182 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000071591.1">
        <property type="protein sequence ID" value="ENSMODP00000042456.1"/>
        <property type="gene ID" value="ENSMODG00000001785.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157598"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001785">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12713">
        <property type="entry name" value="RRM_TNRC6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14283">
        <property type="entry name" value="UBA_TNR6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000011">
        <property type="entry name" value="trinucleotide repeat-containing gene 6A protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000027">
        <property type="entry name" value="Trinucleotide repeat-containing gene 6C protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019486">
        <property type="entry name" value="Argonaute_hook_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052068">
        <property type="entry name" value="GW182_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026805">
        <property type="entry name" value="GW182_M_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041917">
        <property type="entry name" value="TNR6C_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032226">
        <property type="entry name" value="TNRC6_PABC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034927">
        <property type="entry name" value="TNRC6C_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13020">
        <property type="entry name" value="TRINUCLEOTIDE REPEAT-CONTAINING GENE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13020:SF9">
        <property type="entry name" value="TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10427">
        <property type="entry name" value="Ago_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12938">
        <property type="entry name" value="M_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16608">
        <property type="entry name" value="TNRC6-PABC_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="UBA" evidence="11">
        <location>
            <begin position="1191"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="497"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="820"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1071"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1162"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1340"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1471"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1537"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1670"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1743"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1873"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1439"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="844"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1022"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1162"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1487"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1545"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1673"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1755"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1879"/>
            <end position="1899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1967" mass="207283" checksum="A18366467EA338EF" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4U8</accession>
    <name>A0A5F8G4U8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Gamma-synuclein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SNCG</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the synuclein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4U8"/>
    <dbReference type="FunCoup" id="A0A5F8G4U8">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042503"/>
    <dbReference type="Ensembl" id="ENSMODT00000083490.1">
        <property type="protein sequence ID" value="ENSMODP00000042503.1"/>
        <property type="gene ID" value="ENSMODG00000046065.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183175"/>
    <dbReference type="InParanoid" id="A0A5F8G4U8"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000046065">
        <property type="expression patterns" value="Expressed in spinal cord and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903136">
        <property type="term" value="F:cuprous ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.700:FF:000002">
        <property type="entry name" value="Gamma-synuclein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001058">
        <property type="entry name" value="Synuclein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002462">
        <property type="entry name" value="Synuclein_gamma"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13820:SF10">
        <property type="entry name" value="GAMMA-SYNUCLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13820">
        <property type="entry name" value="SYNUCLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01387">
        <property type="entry name" value="Synuclein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01214">
        <property type="entry name" value="GSYNUCLEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01211">
        <property type="entry name" value="SYNUCLEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118375">
        <property type="entry name" value="Synuclein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="183" mass="19289" checksum="B0857793AD3F6BFD" modified="2019-12-11" version="1">MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGTKTKEGVVQSVTSVAEKTKEQANLVSDVMVASVNTVANKTVEEAENIVVTSGIVRKEDLVNPAQPEHGAPEEQPAEAAEVTEEVGAPDAFFPLSPGLDRFSLFSPLLPASWASVTAAIRGAEEKGFPPCGLFSLLLSPFILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4V0</accession>
    <name>A0A5F8G4V0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgin A4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GOLGA4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000075673.1">
        <property type="protein sequence ID" value="ENSMODP00000042470.1"/>
        <property type="gene ID" value="ENSMODG00000013315.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111139"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013315">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101283">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="3">
        <location>
            <begin position="2003"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1373"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1592"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1688"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1921"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1954"/>
            <end position="1981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2064" mass="239932" checksum="A1552DCA3513D218" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4V2</accession>
    <name>A0A5F8G4V2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TNF receptor associated factor 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRAF7</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4V2"/>
    <dbReference type="FunCoup" id="A0A5F8G4V2">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042508"/>
    <dbReference type="Ensembl" id="ENSMODT00000056549.1">
        <property type="protein sequence ID" value="ENSMODP00000042508.1"/>
        <property type="gene ID" value="ENSMODG00000015943.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157022"/>
    <dbReference type="InParanoid" id="A0A5F8G4V2"/>
    <dbReference type="OMA" id="CMTVTNG"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015943">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000060">
        <property type="term" value="P:positive regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035519">
        <property type="term" value="P:protein K29-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16644">
        <property type="entry name" value="mRING-HC-C3HC3D_TRAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000210">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRAF7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000224">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRAF7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000096">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRAF7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF6">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="10">
        <location>
            <begin position="223"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="436"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="556"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="6">
        <location>
            <begin position="223"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="704" mass="78156" checksum="7ACB5D33F3D25AD0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G563</accession>
    <name>A0A5F8G563_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FosB proto-onco, AP-1 transcription factor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FOSB</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_056652321.1">
        <property type="nucleotide sequence ID" value="XM_056796343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G563"/>
    <dbReference type="Ensembl" id="ENSMODT00000053664.1">
        <property type="protein sequence ID" value="ENSMODP00000042585.1"/>
        <property type="gene ID" value="ENSMODG00000021545.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100010781"/>
    <dbReference type="CTD" id="2354"/>
    <dbReference type="GeneTree" id="ENSGT00940000160358"/>
    <dbReference type="OMA" id="GCKIPFA"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021545">
        <property type="expression patterns" value="Expressed in spermatid and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14721">
        <property type="entry name" value="bZIP_Fos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000006">
        <property type="entry name" value="fos-related antigen 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF3">
        <property type="entry name" value="PROTEIN FOSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="234" mass="25072" checksum="865543782F8C2691" modified="2019-12-11" version="1">MFQAFPGDYDSASRCSSSPSAESQYLSSVDSFGSPTTAAASQECAGLGDMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQQPPLGPQLPTVDPYDLPGTSYSSPGISGYGSGAGPSGAASAGPPPSRPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLQFVLAAHKPGCKIPFDEGPGPGGPLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G565</accession>
    <name>A0A5F8G565_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo-keto reductase family 1 member D1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">AKR1D1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G565"/>
    <dbReference type="Ensembl" id="ENSMODT00000070271.1">
        <property type="protein sequence ID" value="ENSMODP00000042597.1"/>
        <property type="gene ID" value="ENSMODG00000013856.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155961"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013856">
        <property type="expression patterns" value="Expressed in liver and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000003">
        <property type="entry name" value="Aldo-keto reductase family 1 member C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="336" mass="38570" checksum="6A21A8309D6D1684" modified="2019-12-11" version="1">MNLTASDHRIPLNDGSSIPIIGLGTFSNKRFKDLCFQSVKTAIDVGYRHFDGAYIYHNEHEVGRAIQEKIAEEKVKREDIFYCGKLWSTFLKPEMVQPALEKTLNSLQLDYVDLYIIELPIALKAGENIFPKDENGKWLFDEVNLCSTWEALEACKDKGLVKSLGVSNFNRRQLELILNKPGLKYKPVCNQVECHPYFIQTKLLKFCQNHDIVMVAYSPLGTNRDPSWVNIHCPPLLQDPLLISLGQKYSKTPAQISLRFNIQRGIVVIPNSFNNDRIKENFQIFDFSLTDEEMKSIEGLNKGVRFVKLSRFFSSEDGHSQVILQILILLLYIMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G566</accession>
    <name>A0A5F8G566_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SMC5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Forms a heterodimer with smc6. Component of the SMC5-SMC6 complex which consists at least of smc5, smc6, nsmce2, nsmce1 and nsmce4a.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G566"/>
    <dbReference type="Ensembl" id="ENSMODT00000070396.1">
        <property type="protein sequence ID" value="ENSMODP00000042638.1"/>
        <property type="gene ID" value="ENSMODG00000002801.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074816"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002801">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000793">
        <property type="entry name" value="Structural maintenance of chromosomes protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="160"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="552"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="669"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="769"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="985" mass="116165" checksum="36292BFABAC89897" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G567</accession>
    <name>A0A5F8G567_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PLCL2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G567"/>
    <dbReference type="Ensembl" id="ENSMODT00000067038.1">
        <property type="protein sequence ID" value="ENSMODP00000042561.1"/>
        <property type="gene ID" value="ENSMODG00000014736.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155660"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014736">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050811">
        <property type="term" value="F:GABA receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032228">
        <property type="term" value="P:regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16223">
        <property type="entry name" value="EFh_PRIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13364">
        <property type="entry name" value="PH_PLC_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08597">
        <property type="entry name" value="PI-PLCc_PRIP_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000025">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000017">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000001">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028382">
        <property type="entry name" value="PLCL2_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF84">
        <property type="entry name" value="INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="150"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="627"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="743"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1038" mass="115423" checksum="E0868A7AC612E8A5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G568</accession>
    <name>A0A5F8G568_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">TP53-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TP53BP1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000086357.1">
        <property type="protein sequence ID" value="ENSMODP00000042579.1"/>
        <property type="gene ID" value="ENSMODG00000017806.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011891"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017806">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140005">
        <property type="term" value="F:histone H4K20me2 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045830">
        <property type="term" value="P:positive regulation of isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20383">
        <property type="entry name" value="Tudor_53BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000021">
        <property type="entry name" value="Tumor suppressor p53-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000019">
        <property type="entry name" value="Tumor suppressor p53-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000003">
        <property type="entry name" value="Tumor suppressor p53-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000005">
        <property type="entry name" value="Tumor suppressor p53-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015125">
        <property type="entry name" value="53-BP1_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09038">
        <property type="entry name" value="53-BP1_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18428">
        <property type="entry name" value="BRCT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0010">Activator</keyword>
    <keyword evidence="17" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="1550"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="1704"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="425"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="492"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="591"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="747"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="882"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="910"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1008"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1091"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1447"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1572"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="679"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="913"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1015"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1095"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1121"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1139"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1230"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1460"/>
            <end position="1476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1812" mass="198219" checksum="1B69D2DF1050C35A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G570</accession>
    <name>A0A5F8G570_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Forkhead box J3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FOXJ3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G570"/>
    <dbReference type="Ensembl" id="ENSMODT00000087189.1">
        <property type="protein sequence ID" value="ENSMODP00000042602.1"/>
        <property type="gene ID" value="ENSMODG00000017320.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160362"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017320">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20052">
        <property type="entry name" value="FH_FOXJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000088">
        <property type="entry name" value="Forkhead box protein J3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="78"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="78"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="560" mass="62131" checksum="178AEB9A725A1E8D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G571</accession>
    <name>A0A5F8G571_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Inositol oxygenase</fullName>
            <ecNumber evidence="4 15">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 15">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MIOX</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 15">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 15">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 15"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G571"/>
    <dbReference type="Ensembl" id="ENSMODT00000068345.1">
        <property type="protein sequence ID" value="ENSMODP00000042595.1"/>
        <property type="gene ID" value="ENSMODG00000045265.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016211"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000045265">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="14">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="314" mass="36485" checksum="A0BC8533AD1EB06D" modified="2019-12-11" version="1">MCGPDPSEIYRPEGNKNKEDFRNYTSGPHQDRVYNTYKLMHTYQTVDFVRRKHVEFGGFSYKKMTVMEAVDLLDELVDESDPDVDFPNSFHAFQTAEGIRKAHPDKDWFHLVGLLHDLGKILVLAGEPQWAVVGDTFPVGCRPQKSVVFGDSTFQDNPDAKDPRYCTEYGMYEPHCGLEKVLMSWGHDEYMYQMMKFNKFSLPPEAFYMIRFHSFYPWHTGGDYQHLCSTHDLNMLPWVQEFNKFDLYTKSEDLPDVTELRPYYQGLIDKYCPGIHCWLPMELEEGNGTSTLLLMSDCPVAMKIELTLPLSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G572</accession>
    <name>A0A5F8G572_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein-glutamine gamma-glutamyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TGM6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:54816"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:14005"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:138370"/>
            <dbReference type="EC" id="2.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G572"/>
    <dbReference type="Ensembl" id="ENSMODT00000082604.1">
        <property type="protein sequence ID" value="ENSMODP00000042643.1"/>
        <property type="gene ID" value="ENSMODG00000013942.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244866"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013942">
        <property type="expression patterns" value="Expressed in spermatid and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000278">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000001">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000171">
        <property type="entry name" value="protein-glutamine gamma-glutamyltransferase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF50">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="10">
        <location>
            <begin position="248"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="690" mass="78182" checksum="ABDD22AACEB9BD57" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G573</accession>
    <name>A0A5F8G573_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin tyrosine ligase like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TTLL7</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G573"/>
    <dbReference type="Ensembl" id="ENSMODT00000057897.1">
        <property type="protein sequence ID" value="ENSMODP00000042566.1"/>
        <property type="gene ID" value="ENSMODG00000000596.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159078"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000596">
        <property type="expression patterns" value="Expressed in spermatocyte and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000009">
        <property type="entry name" value="tubulin polyglutamylase TTLL5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF147">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="852" mass="99521" checksum="49D9784C91D0D1E7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUW4</accession>
    <name>A0A5F8GUW4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-acetyltaurine hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Phosphotriesterase-related protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PTER</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-acetyl-L-isoleucine + H2O = L-isoleucine + acetate</text>
            <dbReference type="Rhea" id="RHEA:81119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:133735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:81120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-leucine + H2O = L-leucine + acetate</text>
            <dbReference type="Rhea" id="RHEA:81115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:58270"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:81116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-acetyl-L-methionine + H2O = L-methionine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:71670"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67441"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-L-valine + H2O = L-valine + acetate</text>
            <dbReference type="Rhea" id="RHEA:81123"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:133716"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:81124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-acetyltaurine + H2O = taurine + acetate</text>
            <dbReference type="Rhea" id="RHEA:81107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:133737"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:81108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-propanoyltaurine + H2O = propanoate + taurine</text>
            <dbReference type="Rhea" id="RHEA:81111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17272"/>
            <dbReference type="ChEBI" id="CHEBI:231795"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:81112"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUW4"/>
    <dbReference type="Ensembl" id="ENSMODT00000071597.1">
        <property type="protein sequence ID" value="ENSMODP00000051423.1"/>
        <property type="gene ID" value="ENSMODG00000009960.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006960"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009960">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00530">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017947">
        <property type="entry name" value="AryldialkylPase_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819:SF3">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01322">
        <property type="entry name" value="PHOSPHOTRIESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="302" mass="33565" checksum="38A19C3F954357AE" modified="2019-12-11" version="1">MASLSGKVQTVLGLVEPSQLGQTLTHEHLTMTFDCCYTPPWSGQEALSKRSFEMKNLFWIQNNPYSHKENLRLNQETEAIKEELLYYKASGGGALVENTTSGISRNVKTLKWFAEETGVHIISGAGFYVDGTHSPETRAMSIEQLTEIITNEILHGADGTDIKCGVIGEIGCSWPLTESENKVLQATAHAQSQLGCPVIVHPGRNPNSPFQIIRILQEAGADVSKTVMSHLDRIRLLANEGYEDRLLIAHDIHTKHRLMKYGGHGYSHILNNIVPKMLIRGISKNAIGKILVENPKQWLTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUW5</accession>
    <name>A0A5F8GUW5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgin A4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GOLGA4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000088688.1">
        <property type="protein sequence ID" value="ENSMODP00000051335.1"/>
        <property type="gene ID" value="ENSMODG00000013315.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111139"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013315">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101283">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="3">
        <location>
            <begin position="2059"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1447"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1767"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1817"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1984"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1825"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1994"/>
            <end position="2004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2120" mass="245787" checksum="6DAFA403AD894AF0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUW9</accession>
    <name>A0A5F8GUW9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUW9"/>
    <dbReference type="Ensembl" id="ENSMODT00000085319.1">
        <property type="protein sequence ID" value="ENSMODP00000051340.1"/>
        <property type="gene ID" value="ENSMODG00000049580.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100013306"/>
    <dbReference type="CTD" id="4133"/>
    <dbReference type="GeneTree" id="ENSGT00940000156597"/>
    <dbReference type="OrthoDB" id="9378527at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000049580">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018459">
        <property type="entry name" value="RII-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF15">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10522">
        <property type="entry name" value="RII_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RII binding" evidence="9">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="471" mass="49950" checksum="4ACD48819DD1AF78" modified="2019-12-11" version="1">MADDRKDEAKAPHWTSSQLAEASSHPHSPELKEQGGAGDGIVRSANGFPYREEEEGGYGDHGQQGTYSTTKENGINGELTTAERETAEEVSARIVQVVTAEAVAVLKGEQEKEAQPKDQPTGLPIAVEESANLPPSPPPSPASEQTGTLEEAAGGETNQASGTFKQGKDRFSDGVSKSPEKRSSLPRPSSILPTRRGVSGDRDENSFSLNTSMSSSVRRTTRSEPIRRTGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPTEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVRSKIGSTDNIRYQPKGGQIQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHIPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUX1</accession>
    <name>A0A5F8GUX1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glomulin, FKBP associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GLMN</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUX1"/>
    <dbReference type="Ensembl" id="ENSMODT00000078846.1">
        <property type="protein sequence ID" value="ENSMODP00000051428.1"/>
        <property type="gene ID" value="ENSMODG00000011826.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018446"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011826">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019516">
        <property type="entry name" value="Glomulin/ALF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15430">
        <property type="entry name" value="GLOMULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15430:SF1">
        <property type="entry name" value="GLOMULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="590" mass="67452" checksum="55F658D7357CEF2E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUX4</accession>
    <name>A0A5F8GUX4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="13">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DBT</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:18865"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="2.3.1.168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:18866"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_007485090.1">
        <property type="nucleotide sequence ID" value="XM_007485028.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUX4"/>
    <dbReference type="FunCoup" id="A0A5F8GUX4">
        <property type="interactions" value="1661"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051345"/>
    <dbReference type="Ensembl" id="ENSMODT00000080321.1">
        <property type="protein sequence ID" value="ENSMODP00000051345.1"/>
        <property type="gene ID" value="ENSMODG00000003588.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100032961"/>
    <dbReference type="KEGG" id="mdo:100032961"/>
    <dbReference type="CTD" id="1629"/>
    <dbReference type="GeneTree" id="ENSGT00940000156750"/>
    <dbReference type="InParanoid" id="A0A5F8GUX4"/>
    <dbReference type="OMA" id="MPFCIKA"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003588">
        <property type="expression patterns" value="Expressed in endometrium and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160157">
        <property type="term" value="C:branched-chain alpha-ketoacid dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120552">
        <property type="term" value="P:branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000009">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000002">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 13" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="64"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="15">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="503" mass="55786" checksum="120C83083AC72461" modified="2019-12-11" version="1">MAAARVLRSWSRSARHLSCVNHIQICRSIHAVKPKYTCLFGYSSFQFSHPHRLLRTTSTVSGQIVQFKLSDIGEGITEVIVKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGIIRKLYYALEDTAFVGKPLVDIETESLKGVDRTTDRTKLVNKDSEEDVVETPAVFHDEHTHQEIKGHKTLATPAVRRLAMENNIKLSEVVGTGKDGRILKEDILNYLAKQTGAILPPSPKSEIITPLPKSEKIQTIPKDKPIPLPVSKPKVFTDKDRTEPITGFERAMVKTMTMAMKIPHFGYCDEVDLTELVKLREQLKPLALARGIKLSYMPFFLKAASLGLLQFPILNASVDENCQNITYKASHNIGVAMDTSQGLIVPNVKNVQLCSVFEIATELNRLQKLGATNQLGTADITGGTFTLSNIGSIGGTYAKPVILPPEVAIGAFGAIKVLPRFNEKGKLIKTQIMNVSWSADHRIIDGATMSRFSNLWKSYLENPASMLLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GUX9</accession>
    <name>A0A5F8GUX9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KIF6</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GUX9"/>
    <dbReference type="Ensembl" id="ENSMODT00000080292.1">
        <property type="protein sequence ID" value="ENSMODP00000051350.1"/>
        <property type="gene ID" value="ENSMODG00000013129.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157697"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013129">
        <property type="expression patterns" value="Expressed in spermatocyte and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000039">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056524">
        <property type="entry name" value="KIF6/9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF67">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23735">
        <property type="entry name" value="KIF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="5"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="692"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="718" mass="82457" checksum="7C5CDCC84B6EAB74" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV84</accession>
    <name>A0A5F8GV84_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Lactotransferrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LTF</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the transferrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV84"/>
    <dbReference type="Ensembl" id="ENSMODT00000079566.1">
        <property type="protein sequence ID" value="ENSMODP00000051450.1"/>
        <property type="gene ID" value="ENSMODG00000018479.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156055"/>
    <dbReference type="OMA" id="DEWSINS"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018479">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13617">
        <property type="entry name" value="PBP2_transferrin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13618">
        <property type="entry name" value="PBP2_transferrin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000095">
        <property type="entry name" value="Lactotransferrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016357">
        <property type="entry name" value="Transferrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018195">
        <property type="entry name" value="Transferrin_Fe_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF31">
        <property type="entry name" value="SEROTRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002549">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00422">
        <property type="entry name" value="TRANSFERRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00094">
        <property type="entry name" value="TR_FER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00205">
        <property type="entry name" value="TRANSFERRIN_LIKE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00206">
        <property type="entry name" value="TRANSFERRIN_LIKE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00207">
        <property type="entry name" value="TRANSFERRIN_LIKE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023880766" evidence="14">
        <location>
            <begin position="20"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="15">
        <location>
            <begin position="25"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="15">
        <location>
            <begin position="366"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="134"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="490"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="514"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR002549-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR002549-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR002549-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="713" mass="78880" checksum="18702A756FD2B884" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV85</accession>
    <name>A0A5F8GV85_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Intraflagellar transport 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">IFT20</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV85"/>
    <dbReference type="Ensembl" id="ENSMODT00000072979.1">
        <property type="protein sequence ID" value="ENSMODP00000051543.1"/>
        <property type="gene ID" value="ENSMODG00000019233.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003413"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019233">
        <property type="expression patterns" value="Expressed in ovary and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028172">
        <property type="entry name" value="FT20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14931">
        <property type="entry name" value="IFT20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="74" mass="8301" checksum="14EAC9CAE3E92895" modified="2019-12-11" version="1">MAKDILGDAGLHFDELNKLRVLDPEVTQQTIELKEECKDFVDKIGQFQKIVGGLIELVDQLAKEAENEKMKVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV87</accession>
    <name>A0A5F8GV87_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polypyrimidine tract-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PTBP1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV87"/>
    <dbReference type="Ensembl" id="ENSMODT00000080866.1">
        <property type="protein sequence ID" value="ENSMODP00000051422.1"/>
        <property type="gene ID" value="ENSMODG00000006302.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244924"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006302">
        <property type="expression patterns" value="Expressed in forelimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903312">
        <property type="term" value="P:negative regulation of mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12777">
        <property type="entry name" value="RRM1_PTBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12782">
        <property type="entry name" value="RRM2_PTBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12695">
        <property type="entry name" value="RRM3_PTBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12701">
        <property type="entry name" value="RRM4_PTBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000036">
        <property type="entry name" value="polypyrimidine tract-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000162">
        <property type="entry name" value="polypyrimidine tract-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000018">
        <property type="entry name" value="Polypyrimidine tract-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000032">
        <property type="entry name" value="Polypyrimidine tract-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006536">
        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055204">
        <property type="entry name" value="HNRNPL_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035000">
        <property type="entry name" value="PTBP1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035001">
        <property type="entry name" value="PTBP1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22976">
        <property type="entry name" value="RRM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023832724" description="Polypyrimidine tract-binding protein 1" evidence="16">
        <location>
            <begin position="22"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="77"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="202"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="355"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="472"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="549" mass="59620" checksum="78DC989AADFB5D09" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV89</accession>
    <name>A0A5F8GV89_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Voltage-dependent R-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">CACNA1E</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000076224.1">
        <property type="protein sequence ID" value="ENSMODP00000051553.1"/>
        <property type="gene ID" value="ENSMODG00000006729.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155601"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006729">
        <property type="expression patterns" value="Expressed in cerebellum and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000011">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000013">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000015">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000023">
        <property type="entry name" value="Voltage-dependent R-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000025">
        <property type="entry name" value="Voltage-dependent R-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005449">
        <property type="entry name" value="VDCC_R_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF5">
        <property type="entry name" value="VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01633">
        <property type="entry name" value="RVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="974"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1046"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1107"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1219"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1300"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1330"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1359"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1424"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1517"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-1 subunit IQ" evidence="23">
        <location>
            <begin position="1678"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="914"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1836"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2037"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="914"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1839"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1875"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1894"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1911"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1984"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1190"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2087" mass="236120" checksum="6FE23B91BD0691B7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV90</accession>
    <name>A0A5F8GV90_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Promyelocytic leukemia</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV90"/>
    <dbReference type="Ensembl" id="ENSMODT00000081113.1">
        <property type="protein sequence ID" value="ENSMODP00000051558.1"/>
        <property type="gene ID" value="ENSMODG00000009808.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048454"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009808">
        <property type="expression patterns" value="Expressed in cerebellum and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19804">
        <property type="entry name" value="Bbox1_TRIM19_C-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19770">
        <property type="entry name" value="Bbox2_TRIM19_C-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16579">
        <property type="entry name" value="RING-HC_PML_C-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021978">
        <property type="entry name" value="PML-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057617">
        <property type="entry name" value="PML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF302">
        <property type="entry name" value="PROTEIN PML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25244">
        <property type="entry name" value="PML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12126">
        <property type="entry name" value="PML_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="182"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="889"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="913" mass="101918" checksum="DE5A6B55FBF91151" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV91</accession>
    <name>A0A5F8GV91_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HELZ2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="Ensembl" id="ENSMODT00000061853.1">
        <property type="protein sequence ID" value="ENSMODP00000051455.1"/>
        <property type="gene ID" value="ENSMODG00000016966.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160694"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016966">
        <property type="expression patterns" value="Expressed in blood and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001803">
        <property type="entry name" value="Helicase with zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001313">
        <property type="entry name" value="Helicase with zinc finger domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001373">
        <property type="entry name" value="Helicase with zinc finger domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056787">
        <property type="entry name" value="OB_HELZ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF16">
        <property type="entry name" value="HELICASE WITH ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25049">
        <property type="entry name" value="OB_HELZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2844" mass="323747" checksum="643F597FD4346B3B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV93</accession>
    <name>A0A5F8GV93_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PTCD2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PTCD2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV93"/>
    <dbReference type="Ensembl" id="ENSMODT00000077197.1">
        <property type="protein sequence ID" value="ENSMODP00000051121.1"/>
        <property type="gene ID" value="ENSMODG00000049464.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009329"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000049464">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034913">
        <property type="entry name" value="mS27/PTCD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034629">
        <property type="entry name" value="PTCD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14700">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14700:SF0">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10037">
        <property type="entry name" value="MRP-S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="6">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="362" mass="41848" checksum="A345E4474AA76CB8" modified="2019-12-11" version="1">MIKNFGNCNVLPKCNVLLCKNNCQLTTKYISFSGFFSLQLLGKRYLLTDDVIKLQEFQQAKVMVSCRFQGKKEIYFKDMEEKMKEKGLILKEELKTLLHLCETQEDMELARNAIYRYHAENRNVCFGEFKFGPLFIRLCYELDLEQSAVELIKDQHLKGFFSDCTSFNILMNMLFIKDNYEGALEVLIEMKNQGVKFNKDTYVLAFAICYKLNSAKSFNTSMNLLDEALIKGEVLTKRAYSFAIALALKQVLIHAHSGLLEGALQILEASTEKTHSSLVRKPEFSEEVLATVKEKLYGQPALQDRFREIYNRLQVAYQIIPQTVDAILCVIPQRKKPDVLSFNRRQISRRTLQPLNSFLMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GV94</accession>
    <name>A0A5F8GV94_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Neural cell adhesion molecule 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NCAM2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GV94"/>
    <dbReference type="Ensembl" id="ENSMODT00000082386.1">
        <property type="protein sequence ID" value="ENSMODP00000051279.1"/>
        <property type="gene ID" value="ENSMODG00000020992.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157860"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020992">
        <property type="expression patterns" value="Expressed in spinal cord and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05866">
        <property type="entry name" value="IgI_1_NCAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000086">
        <property type="entry name" value="Neural cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000381">
        <property type="entry name" value="Neural cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000436">
        <property type="entry name" value="Neural cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000450">
        <property type="entry name" value="Neural cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000528">
        <property type="entry name" value="Neural cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000575">
        <property type="entry name" value="Neural cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000636">
        <property type="entry name" value="Neural cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009138">
        <property type="entry name" value="Neural_cell_adh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF231">
        <property type="entry name" value="NEURAL CELL ADHESION MOLECULE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01838">
        <property type="entry name" value="NCAMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="133"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="228"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="322"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="421"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="518"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="613"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="752"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="801" mass="89897" checksum="EE029B57E880A5AB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVX0</accession>
    <name>A0A5F8GVX0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MDM4 regulator of p53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MDM4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM2/MDM4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVX0"/>
    <dbReference type="Ensembl" id="ENSMODT00000072285.1">
        <property type="protein sequence ID" value="ENSMODP00000051798.1"/>
        <property type="gene ID" value="ENSMODG00000001605.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063539"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001605">
        <property type="expression patterns" value="Expressed in uterus and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17673">
        <property type="entry name" value="MDM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.245.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase Mdm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858">
        <property type="entry name" value="OS05G0521000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858:SF12">
        <property type="entry name" value="PROTEIN MDM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DM2" evidence="10">
        <location>
            <begin position="25"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="212" mass="22979" checksum="37D485076036F822" modified="2019-12-11" version="1">MSLSPTSTHCSASENACKISPGQVNQVRPKLPLLKILQAAGAHGEMFTMKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGLQSFSVKDPSPLYDMLRKNLVTATVTDAAQTLALAQDQSMDIPSQDQLKQGTEGSSSSRNGTEEGDDPALSTSQRKCRNPKEGSRIPGPPLPHLGREATFTTTSLPGMISWGPQQPPFPALLALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVX1</accession>
    <name>A0A5F8GVX1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Carboxypeptidase B2</fullName>
            <ecNumber evidence="20">3.4.17.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Carboxypeptidase U</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Thrombin-activable fibrinolysis inhibitor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">CPB2</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Release of C-terminal Arg and Lys from a polypeptide.</text>
            <dbReference type="EC" id="3.4.17.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 24">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.20" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVX1"/>
    <dbReference type="Ensembl" id="ENSMODT00000072973.1">
        <property type="protein sequence ID" value="ENSMODP00000051695.1"/>
        <property type="gene ID" value="ENSMODG00000014975.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159160"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014975">
        <property type="expression patterns" value="Expressed in liver and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06246">
        <property type="entry name" value="M14_CPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000003">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033849">
        <property type="entry name" value="CPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF17">
        <property type="entry name" value="CARBOXYPEPTIDASE B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0280">Fibrinolysis</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M14" evidence="25">
        <location>
            <begin position="110"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="24">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00053927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00066563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00070087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00075534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00078332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="411" mass="47707" checksum="407A47485F39C02F" modified="2019-12-11" version="1">FIYASFLTFFSSVGQVLNAFPRTTKQVRLLQNMTMMFEIVLWKPDDVEFIKKSEEVHFYVNDSDVSSVKTFLNQNKIIFRVSVEDVEDLIRKQTINNTVSVRASSSYYQQYHSLDEIYFWIDSITETYSNKLEKIHIGSSFEKRPLYVLKLSVKENTSKNAIWIDCGIHAREWVAPAFCLWFIGYATQFYGKEAKITKLLNNLDFYVMPVLNVDGYDYTWKTNRMWRKNRSRHEGNRCFGTDLNRNFASKYWCELGASNSSCRETYCGPYPESEPEVKAVANFLRRNLDNIKGYISMHSYSQMVLFPYSYTTSKSKDHEELSLVASQAVEAIQRVNENTYYTHGPGAQTIYLAPGGSDDWAYDMGIKYSFTIELRDKGQYGFLLPERFIRPTVTEIFSAVSTIASHVILKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVX2</accession>
    <name>A0A5F8GVX2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVX2"/>
    <dbReference type="Ensembl" id="ENSMODT00000073774.1">
        <property type="protein sequence ID" value="ENSMODP00000051509.1"/>
        <property type="gene ID" value="ENSMODG00000003861.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155457"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003861">
        <property type="expression patterns" value="Expressed in cerebellum and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000053">
        <property type="entry name" value="Roundabout guidance receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000026">
        <property type="entry name" value="roundabout homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000043">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF37">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="126"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="218"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="315"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="369" mass="40285" checksum="7ACD676657209DF4" modified="2019-12-11" version="1">VCLSPSSHLFLFSGSRAGPEDAVPRIVEQPPDLLVSRGEPATLPCRAEGRPRPDIEWYKDGARVATAREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGVAASRNASLEVAVLRDDFRQSPVDVVVAVGEPAVLECVPPKGHPEPSVSWKKGNLRLKEQEGRITIRGGKLMMSHTLKSDAGMYVCVASNVAGERDSGAAELVVFERPSFLRRPVNQVVLADTPADFPCEVQGDPPPHLRWRKEEGELPIGRYEIGSDYSLRIGRVNAEDEGTYTCVAENSVGRAEASGSLSGKDREGWDTVVSGSAVWLPCKVTGNPEPSVQWLKDGQELNSGDLRLNLLANGTLHITNLQVRHIRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVX6</accession>
    <name>A0A5F8GVX6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase E3D</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HECT-type E3 ubiquitin transferase E3D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">UbcH10-binding protein with a HECT-like domain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2C-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UBE3D</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with UBE2C/UbcH10 (E2 ubiquitin-conjugating enzyme). In vitro, interacts with cyclin-B.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVX6"/>
    <dbReference type="Ensembl" id="ENSMODT00000059782.1">
        <property type="protein sequence ID" value="ENSMODP00000051514.1"/>
        <property type="gene ID" value="ENSMODG00000018395.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003986"/>
    <dbReference type="OMA" id="DCFTGDS"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018395">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="399" mass="45305" checksum="4E74818D8754BBFD" modified="2019-12-11" version="1">MLDLLNQYSLNFFFKWEKTNGKSLYFVINREPKQGSLPMDVSLTPSVLKMKTLEQCREIKFPAEVRLVPSSLRGLQYISGDGIHMRLLVQADLNKKLVTALNQSLQAQKCYVFHCQTCGEIIVKERKLLRVLPLPSENWNALVEEWCCHPDPFANKPLHPGENDCFIGDTHLLVNVRSDSCIPGPEIAQAETHQLSESHLESKPKANTKIICKRCKAMLGETDSSGTTKFYITEIIIQPSGRDFDMIPRSQFVQSVIAQCLVELSSARSTFRFTVQGHDGKTYILVWLLNSDSLLIESLRNSESIQKFSLFEGMESLDSNNIGIRNAVKVLFHPCIKNRNIELSSSWENDIGVHSLVLPSQTCLELLLILLRSNHSLPPSLQYMNSFQILSFPFYRGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVX8</accession>
    <name>A0A5F8GVX8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Solute carrier family 24 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SLC24A3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVX8"/>
    <dbReference type="Ensembl" id="ENSMODT00000052857.1">
        <property type="protein sequence ID" value="ENSMODP00000051677.1"/>
        <property type="gene ID" value="ENSMODG00000005890.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234532"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005890">
        <property type="expression patterns" value="Expressed in spinal cord and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000037">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000005">
        <property type="entry name" value="sodium/potassium/calcium exchanger 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF42">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="13">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="13">
        <location>
            <begin position="380"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="282"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="548" mass="60708" checksum="97C893A4D3F30BD1" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVX9</accession>
    <name>A0A5F8GVX9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Plexin C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PLXNC1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000088927.1">
        <property type="protein sequence ID" value="ENSMODP00000051321.1"/>
        <property type="gene ID" value="ENSMODG00000009408.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286928"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009408">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12789">
        <property type="entry name" value="RasGAP_plexin_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000033">
        <property type="entry name" value="PLeXin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000797">
        <property type="entry name" value="Plexin C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000020">
        <property type="entry name" value="Plexin C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF4">
        <property type="entry name" value="PLEXIN-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023921197" evidence="11">
        <location>
            <begin position="44"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="914"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="14">
        <location>
            <begin position="57"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="12">
        <location>
            <begin position="421"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="12">
        <location>
            <begin position="559"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="13">
        <location>
            <begin position="722"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="13">
        <location>
            <begin position="812"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1537" mass="172268" checksum="C8F8694125C8F5EE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVY2</accession>
    <name>A0A5F8GVY2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Neuronal acetylcholine receptor subunit beta-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">CHRNB4</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Neuronal AChR is composed of two different types of subunits: alpha and beta. CHRNB4/Beta-4 subunit can be combined to CHRNA2/alpha-2, CHRNA3/alpha-3 or CHRNA4/alpha-4, CHRNA5/alpha-5 and CHRNB3/beta-3 to give rise to functional receptors. Forms stoichiometries such as (CHRNA3)2:(CHRNB4)3 or (CHRNA3:CHRNB4)2:CHRNB3. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub-subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVY2"/>
    <dbReference type="Ensembl" id="ENSMODT00000058009.1">
        <property type="protein sequence ID" value="ENSMODP00000051519.1"/>
        <property type="gene ID" value="ENSMODG00000011891.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158708"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011891">
        <property type="expression patterns" value="Expressed in cerebellum and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000006">
        <property type="entry name" value="Cholinergic receptor nicotinic beta 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000008">
        <property type="entry name" value="Cholinergic receptor nicotinic beta 4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000034">
        <property type="entry name" value="Cholinergic receptor nicotinic beta 4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 20" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023969638" description="Neuronal acetylcholine receptor subunit beta-4" evidence="20">
        <location>
            <begin position="23"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="22">
        <location>
            <begin position="32"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="23">
        <location>
            <begin position="244"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="489" mass="55821" checksum="9B5DCFA0E8AF462B" modified="2019-12-11" version="1">MRKAPTLLFLLLLLLAMVSIFCNRNCRMANAEEKLMNFLLNKTRYNNLIRPAANSSQLVSISLQVILAQLISVNEREQIMTTNIWLKQEWTDYRLAWNSSQYEGVNILRIPSKRIWLPDIVLYNNADGTYEVSVYTNAVVSSNGSIFWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKTPTASMDDFTPSGEWDIIELPGRRTVNPLDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKVLFLERLPTFLFMKRPVNNPTRSQIDQRRRNKSESLHNASTGNLYKNSMYFVNPTSAPRAAGGTDSSGGQKDLRLRSFKRYQPEVQEAIDGVSFIADHMKSDDSDQCVIEDWKYVAMVVDRLFLWIFICVCVLGTAGLFLPPLFQNYSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVY4</accession>
    <name>A0A5F8GVY4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cyclic nucleotide gated channel subunit alpha 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CNGA3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Cs(+)(in) = Cs(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78555"/>
            <dbReference type="ChEBI" id="CHEBI:49547"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Li(+)(in) = Li(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78551"/>
            <dbReference type="ChEBI" id="CHEBI:49713"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NH4(+)(in) = NH4(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28747"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Rb(+)(in) = Rb(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78547"/>
            <dbReference type="ChEBI" id="CHEBI:49847"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056664163.1">
        <property type="nucleotide sequence ID" value="XM_056808185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVY4"/>
    <dbReference type="Ensembl" id="ENSMODT00000079158.1">
        <property type="protein sequence ID" value="ENSMODP00000051326.1"/>
        <property type="gene ID" value="ENSMODG00000001004.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013116"/>
    <dbReference type="CTD" id="1261"/>
    <dbReference type="GeneTree" id="ENSGT00940000158737"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001004">
        <property type="expression patterns" value="Expressed in spermatid and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000002">
        <property type="entry name" value="Cyclic nucleotide gated channel alpha 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000030">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.300:FF:000002">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032406">
        <property type="entry name" value="CLZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF6">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16526">
        <property type="entry name" value="CLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="17">
        <location>
            <begin position="466"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="607"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="680" mass="78863" checksum="079E435B6B470C21" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW90</accession>
    <name>A0A5F8GW90_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cysteine protease</fullName>
            <ecNumber evidence="19">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ATG4B</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine</text>
            <dbReference type="Rhea" id="RHEA:67576"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="Rhea" id="RHEA-COMP:17326"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172942"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:67577"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="19"/>
    <dbReference type="RefSeq" id="XP_016280826.1">
        <property type="nucleotide sequence ID" value="XM_016425340.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW90"/>
    <dbReference type="Ensembl" id="ENSMODT00000081956.1">
        <property type="protein sequence ID" value="ENSMODP00000051619.1"/>
        <property type="gene ID" value="ENSMODG00000008658.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100012560"/>
    <dbReference type="CTD" id="23192"/>
    <dbReference type="GeneTree" id="ENSGT00530000063000"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008658">
        <property type="expression patterns" value="Expressed in blood and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046793">
        <property type="entry name" value="ATG4_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF39">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20166">
        <property type="entry name" value="ATG4_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 19" id="KW-0645">Protease</keyword>
    <keyword evidence="13 19" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="20">
        <location>
            <begin position="40"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="374" mass="42141" checksum="4CF56D7479B7D334" modified="2019-12-11" version="1">MDAATLTYDTLRFAEFEDFPETTDPVWILGRKYTIFTEKDEILSDVTSRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWKQGRRQTDNYFNVLNAFIDKKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEDIRRLCKANFSHTDAAALPPDSDLLSNGYPPGAEVTDRLSQWRPLVLLIPLRLGLTDINEAYTETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQAAVELSNGGVIPDESFHCQHPPCRMNIGELDPSIAVLSRIPGALPMFELVEHQPSHFSCPDVLNLSLDSSDVERLERFFDSEDEDFEILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW93</accession>
    <name>A0A5F8GW93_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">COPS8</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW93"/>
    <dbReference type="FunCoup" id="A0A5F8GW93">
        <property type="interactions" value="3480"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051938"/>
    <dbReference type="Ensembl" id="ENSMODT00000079402.1">
        <property type="protein sequence ID" value="ENSMODP00000051938.1"/>
        <property type="gene ID" value="ENSMODG00000007474.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000977"/>
    <dbReference type="InParanoid" id="A0A5F8GW93"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007474">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000011">
        <property type="entry name" value="COP9 signalosome complex subunit 8-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="255" mass="28390" checksum="88553F703F41F8CD" modified="2019-12-11" version="1">MPVAVMADNAAFSFKKLLDQCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTISSHQWSETIQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGVLKQGWQADSTTRMVMPKKPGSLDVSFNRFIPLSVSSSTKPIILCTRPNCQGVHALRWKLDIPSAFPFGSEPSWSPQLDSFAFECMRKSDPLGPKSPRRNTFQPSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW94</accession>
    <name>A0A5F8GW94_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Protein-tyrosine kinase 2-beta</fullName>
            <ecNumber evidence="7">2.7.10.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Calcium-dependent tyrosine kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Calcium-regulated non-receptor proline-rich tyrosine kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Cell adhesion kinase beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Focal adhesion kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Proline-rich tyrosine kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">PTK2B</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW94"/>
    <dbReference type="Ensembl" id="ENSMODT00000054309.1">
        <property type="protein sequence ID" value="ENSMODP00000051782.1"/>
        <property type="gene ID" value="ENSMODG00000015932.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157269"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015932">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051247">
        <property type="term" value="P:positive regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007172">
        <property type="term" value="P:signal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13190">
        <property type="entry name" value="FERM_C_FAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000004">
        <property type="entry name" value="Protein-tyrosine kinase 2-beta isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.330:FF:000007">
        <property type="entry name" value="protein-tyrosine kinase 2-beta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000142">
        <property type="entry name" value="protein-tyrosine kinase 2-beta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000080">
        <property type="entry name" value="protein-tyrosine kinase 2-beta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000230">
        <property type="entry name" value="protein-tyrosine kinase 2-beta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041390">
        <property type="entry name" value="FADK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049385">
        <property type="entry name" value="FAK1-like_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041784">
        <property type="entry name" value="FAK1/PYK2_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036137">
        <property type="entry name" value="Focal_adhe_kin_target_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005189">
        <property type="entry name" value="Focal_adhesion_kin_target_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF11">
        <property type="entry name" value="NON-SPECIFIC PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21477">
        <property type="entry name" value="FERM_C_FAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18038">
        <property type="entry name" value="FERM_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03623">
        <property type="entry name" value="Focal_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68993">
        <property type="entry name" value="FAT domain of focal adhesion kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="21" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="FERM" evidence="29">
        <location>
            <begin position="39"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="28">
        <location>
            <begin position="404"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00075069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00078211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00083453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="959" mass="109603" checksum="7EEBCBBF9563E269" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW98</accession>
    <name>A0A5F8GW98_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPD52 like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TPD52L2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPD52 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW98"/>
    <dbReference type="Ensembl" id="ENSMODT00000067399.1">
        <property type="protein sequence ID" value="ENSMODP00000051943.1"/>
        <property type="gene ID" value="ENSMODG00000017025.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155572"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017025">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007327">
        <property type="entry name" value="TPD52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307:SF13">
        <property type="entry name" value="TUMOR PROTEIN D54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04201">
        <property type="entry name" value="TPD52"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="239" mass="26223" checksum="4C1CE2CBCF13E55C" modified="2019-12-11" version="1">MDPASQDINLNSPNKGLLSDSMTDVPVDTGSARTTIPEGLTEAEEEELRSELTKVEEEIVTLRQVLAAKERHCGELKRKLGLTPLDGLKQNLTKSWHDVQVSNAYVKTSEKLGEWNEKVTQSDLYLSASSTLEDWNEKLTNSEAYKKTQETLSQAGQKTSAALSNVGSAISRKFGDMSSYSIRHSISMPAMRNSATFKSFEDRVGTIKSKVVGGRENDSDNLPSPTGSSDKPLQDHAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW99</accession>
    <name>A0A5F8GW99_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Regulator of G protein signaling 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RGS6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW99"/>
    <dbReference type="Ensembl" id="ENSMODT00000078815.1">
        <property type="protein sequence ID" value="ENSMODP00000051629.1"/>
        <property type="gene ID" value="ENSMODG00000007000.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157159"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007000">
        <property type="expression patterns" value="Expressed in heart and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08737">
        <property type="entry name" value="RGS_RGS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000162">
        <property type="entry name" value="Regulator of G-protein signaling 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1240.60:FF:000001">
        <property type="entry name" value="Regulator of G-protein signaling 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000002">
        <property type="entry name" value="Regulator of G-protein signaling 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000002">
        <property type="entry name" value="Regulator of G-protein signaling 6 isoform 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047016">
        <property type="entry name" value="RGS6/7/9/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047017">
        <property type="entry name" value="RGS6/7/9/11_DHEX_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037956">
        <property type="entry name" value="RGS6_RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040759">
        <property type="entry name" value="RGS_DHEX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746:SF2">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18148">
        <property type="entry name" value="RGS_DHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="10">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="G protein gamma" evidence="8">
        <location>
            <begin position="226"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="9">
        <location>
            <begin position="301"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="436" mass="50796" checksum="A28FA230E8BB4A7D" modified="2019-12-11" version="1">MQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWFMKNLAIEDPVEAIHLGSLVAAQGYIFPISDHVLTLKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRMKNPQKVKKSVYGVTEESQSQSPVHIPAQPIRKTTKEDIRKQITFLTAQIDRHRLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDITLWDIEMSKEPSQHRVKRWGFSIDEVLKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVATRVEEIWQEFLAPGAQSAINLDSHSYEKTSQNVKDPGRYTYEDAQEHIYKLMKSDSYTRFLRSNAYQDLLQAKKKGKSLVGKRLTGLMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6W6</accession>
    <name>A0A5F8H6W6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Spectrin alpha chain, non-erythrocytic 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Alpha-II spectrin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Fodrin alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SPTAN1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts (via C-terminal spectrin repeats) with TRPC4. Interacts with CALM and EMD. Interacts with isoform 1 of ACP1. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1. Interacts with SHANK3 (via ANK repeats). Interacts with CLN3; this interaction regulates the fodrin localization at the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000069775.1">
        <property type="protein sequence ID" value="ENSMODP00000055299.1"/>
        <property type="gene ID" value="ENSMODG00000006252.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156662"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006252">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11808">
        <property type="entry name" value="SH3_Alpha_Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000007">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000037">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000020">
        <property type="entry name" value="spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000032">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000014">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000006">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000013">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000017">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000020">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000026">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000035">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000043">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000046">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000071">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000078">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000079">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000080">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000036">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000100">
        <property type="entry name" value="spectrin alpha chain, non-erythrocytic 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035825">
        <property type="entry name" value="Alpha_Spectrin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 19" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="967"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="2312"/>
            <end position="2347"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="2355"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="386"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="858"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1126"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1682"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="2161"/>
            <end position="2193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2461" mass="283642" checksum="BA49A6415159828A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6W7</accession>
    <name>A0A5F8H6W7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbonic anhydrase</fullName>
            <ecNumber evidence="8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC100025850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>urea = cyanamide + H2O</text>
            <dbReference type="Rhea" id="RHEA:23056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16698"/>
            <dbReference type="EC" id="4.2.1.69"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6W7"/>
    <dbReference type="Ensembl" id="ENSMODT00000065252.1">
        <property type="protein sequence ID" value="ENSMODP00000055532.1"/>
        <property type="gene ID" value="ENSMODG00000025608.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160385"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025608">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018820">
        <property type="term" value="F:cyanamide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF120">
        <property type="entry name" value="CARBONIC ANHYDRASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="241" mass="26973" checksum="B5048747F2086CF5" modified="2019-12-11" version="1">MSHHNWGYETGVNGPETWHKGYPIALGSKQSPVEIQSKDTEYDSSLKPLEFHYDPSTAKRIVNNGHSFNVEFNDSSDKSVLCGGPLAEKYRLAQFHFHWGSQKQPNGSEHTLNGKQFAAELHLVHWNTKYESMQNAVNKCDGLAVVGVLIEVGSHPMPGLEKITNILDKIQTKGKEATFNDFNPQDLLPNSLEFYTYPGSLTTPPLSECVTWIVLNKPITVSHEQLSVTGDGVSFLQKWMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6X0</accession>
    <name>A0A5F8H6X0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MCF.2 cell line derived transforming sequence-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MCF2L2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6X0"/>
    <dbReference type="Ensembl" id="ENSMODT00000079805.1">
        <property type="protein sequence ID" value="ENSMODP00000054971.1"/>
        <property type="gene ID" value="ENSMODG00000021286.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161734"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021286">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01227">
        <property type="entry name" value="PH_Dbs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000078">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035534">
        <property type="entry name" value="DBS_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF201">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MCF2L2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23289">
        <property type="entry name" value="Spectrin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="7">
        <location>
            <begin position="110"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="593"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="785"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000054971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="962" mass="109166" checksum="93578DAB4969D2BF" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6X3</accession>
    <name>A0A5F8H6X3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein tyrosine phosphatase 4A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PTP4A2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6X3"/>
    <dbReference type="Ensembl" id="ENSMODT00000053002.1">
        <property type="protein sequence ID" value="ENSMODP00000055693.1"/>
        <property type="gene ID" value="ENSMODG00000017554.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154383"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017554">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000012">
        <property type="entry name" value="protein tyrosine phosphatase type IVA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="48"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="136" mass="15655" checksum="956F7AADC8A792C5" modified="2019-12-11" version="1">MNRPAPVEISYENMRFLITHNPTNATLNKFTEDWPFDDGAPPPNQIVDDWLNLLKSKFREEPGCCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFRDTNGHCCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H6X4</accession>
    <name>A0A5F8H6X4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AAK1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H6X4"/>
    <dbReference type="Ensembl" id="ENSMODT00000076257.1">
        <property type="protein sequence ID" value="ENSMODP00000055735.1"/>
        <property type="gene ID" value="ENSMODG00000011819.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155968"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011819">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000072">
        <property type="entry name" value="AP2 associated kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051744">
        <property type="entry name" value="AP2_assoc_SerThr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028182">
        <property type="entry name" value="BMP2K_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47907:SF5">
        <property type="entry name" value="AP2 ASSOCIATED KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47907">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15282">
        <property type="entry name" value="BMP2K_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="46"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="566"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="679"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="734"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1163"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1188" mass="128796" checksum="28657E6674312AD7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H788</accession>
    <name>A0A5F8H788_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="12">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">WWP1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H788"/>
    <dbReference type="Ensembl" id="ENSMODT00000072975.1">
        <property type="protein sequence ID" value="ENSMODP00000055657.1"/>
        <property type="gene ID" value="ENSMODG00000008132.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154635"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008132">
        <property type="expression patterns" value="Expressed in spinal cord and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140678">
        <property type="term" value="F:molecular function inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04021">
        <property type="entry name" value="C2_E3_ubiquitin_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000009">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000023">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000122">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase HACE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF299">
        <property type="entry name" value="NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8 12 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="18">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="18">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="18">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="18">
        <location>
            <begin position="515"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="19">
        <location>
            <begin position="602"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="215"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="339"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13 14">
        <location>
            <position position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="857" mass="97372" checksum="98CCB11533669020" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H789</accession>
    <name>A0A5F8H789_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Roundabout guidance receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ROBO2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H789"/>
    <dbReference type="Ensembl" id="ENSMODT00000066190.1">
        <property type="protein sequence ID" value="ENSMODP00000055850.1"/>
        <property type="gene ID" value="ENSMODG00000016811.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156324"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016811">
        <property type="expression patterns" value="Expressed in cerebellum and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05726">
        <property type="entry name" value="IgI_4_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20952">
        <property type="entry name" value="IgI_5_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000053">
        <property type="entry name" value="Roundabout guidance receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000055">
        <property type="entry name" value="roundabout homolog 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000065">
        <property type="entry name" value="roundabout homolog 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000008">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000043">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000058">
        <property type="entry name" value="roundabout homolog 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF242">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="102"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="195"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="298"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="405"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="518"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="620"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="914"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1068"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1127"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1208"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1265" mass="137902" checksum="6B16431DEFD738EB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H790</accession>
    <name>A0A5F8H790_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H790"/>
    <dbReference type="Ensembl" id="ENSMODT00000068743.1">
        <property type="protein sequence ID" value="ENSMODP00000055414.1"/>
        <property type="gene ID" value="ENSMODG00000000847.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111153"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000847">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001090">
        <property type="entry name" value="T cell receptor beta constant 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="191" mass="21836" checksum="BA8E63C643DEA500" modified="2019-12-11" version="1">LFDQSWVPIPFHFSDDLERVTPPKVTVFQPSEEEIGEKGKATLVCLATGFYPDLVELSWWVNGQETKIGVSTDPEPSKEHPKEEHSSYSLSSRLRISAPFWRNPKNNFRCQVQFYGIAENETWSSNRSKPVTQNVSDQIWGKADCGVTFESYQHSIQSATFFYEILLGKAMLYGLLVSILVLRTMTKKNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H791</accession>
    <name>A0A5F8H791_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synaptotagmin-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SYTL2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H791"/>
    <dbReference type="Ensembl" id="ENSMODT00000072107.1">
        <property type="protein sequence ID" value="ENSMODP00000055091.1"/>
        <property type="gene ID" value="ENSMODG00000004359.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155843"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004359">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08393">
        <property type="entry name" value="C2A_SLP-1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04020">
        <property type="entry name" value="C2B_SLP_1-2-3-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000006">
        <property type="entry name" value="Synaptotagmin-like 5, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000040">
        <property type="entry name" value="synaptotagmin-like protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043567">
        <property type="entry name" value="SYTL1-5_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716:SF5">
        <property type="entry name" value="SYNAPTOTAGMIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="30"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="170"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="336" mass="38595" checksum="63E95B24C73E5665" modified="2019-12-11" version="1">MSKSVPAFLQDEVSGSAMSVYSGDFGNLDIKGSVQFAIDYIDSLMEFHVFVAQCKDLAAADVKKQRSDPYVKTYLLPDKGKMGKKKTLVMKKTLNPVYNEILRYKIDKQSLKNQKLNLSVWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLKWYPLNRRTAPVALEAENRGEMKLALQYVPDPVSGKKPATTGEVHIWVKECIDLPHLRGNHLNSFVKCTILPDTSRKSRQKTRAVGKTNNPIFNHTMVYDGFRPEDLKEACVELTVWDHHKLTNQFLGGLRIGFGTGKSYEIEVDWMDSTPAEISLWERMVNSPNTWIEDILPLRMLLIAKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H792</accession>
    <name>A0A5F8H792_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Progestin and adipoQ receptor family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PAQR4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001371332.1">
        <property type="nucleotide sequence ID" value="XM_001371295.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H792"/>
    <dbReference type="FunCoup" id="A0A5F8H792">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055818"/>
    <dbReference type="Ensembl" id="ENSMODT00000086731.1">
        <property type="protein sequence ID" value="ENSMODP00000055818.1"/>
        <property type="gene ID" value="ENSMODG00000038799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100017929"/>
    <dbReference type="KEGG" id="mdo:100017929"/>
    <dbReference type="CTD" id="124222"/>
    <dbReference type="GeneTree" id="ENSGT00940000157978"/>
    <dbReference type="InParanoid" id="A0A5F8H792"/>
    <dbReference type="OMA" id="HHACPPD"/>
    <dbReference type="OrthoDB" id="535992at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000038799">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000303">
        <property type="term" value="P:regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF138">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="273" mass="29114" checksum="76EB15DBDC5979E2" modified="2019-12-11" version="1">MTFLSGPRLLDWASSPPHLQFNKFVLTGYRPASSGSGCLRSLFYLHNELGNIYTHGLALLGFLVLLPLTMPWGQLGGGGWLGGTHCVACLAPPAGSVLYHLFMCHRGGSPVYARLLALDMCGVCLVNTLGALPIIHCTLACRPWLRPAALVGYTLLSGLAGWRALTAPSTSARLRAFGWQAGARLLVFGARGMGLGAGAPGSLPCYLRMDALALLGGLVNVARLPERWGPGRFDYWGNSHQIMHLLSVGSILQLHAGVVPDLLWAARHACPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H794</accession>
    <name>A0A5F8H794_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">endothelin-converting enzyme 1</fullName>
            <ecNumber evidence="5">3.4.24.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ECE2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.</text>
            <dbReference type="EC" id="3.4.24.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Secretory vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.24.71" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H794"/>
    <dbReference type="Ensembl" id="ENSMODT00000079351.1">
        <property type="protein sequence ID" value="ENSMODP00000055855.1"/>
        <property type="gene ID" value="ENSMODG00000002369.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156921"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002369">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF127">
        <property type="entry name" value="EEF1AKMT4-ECE2 READTHROUGH TRANSCRIPT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="21">
        <location>
            <begin position="183"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="20">
        <location>
            <begin position="628"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="832" mass="94141" checksum="FFC706115B90D930" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H799</accession>
    <name>A0A5F8H799_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KIF6</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H799"/>
    <dbReference type="Ensembl" id="ENSMODT00000087553.1">
        <property type="protein sequence ID" value="ENSMODP00000055860.1"/>
        <property type="gene ID" value="ENSMODG00000013129.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157697"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013129">
        <property type="expression patterns" value="Expressed in spermatocyte and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056524">
        <property type="entry name" value="KIF6/9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF67">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23735">
        <property type="entry name" value="KIF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="626"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="779" mass="88945" checksum="DF1EE32CF4319EEF" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7X0</accession>
    <name>A0A5F8H7X0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Ras-related protein Rab-28</fullName>
            <ecNumber evidence="6">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">RAB28</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="25">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB28 is required for shedding and phagocytosis of cone cell outer segments (OS) discs in the retina. Also participates in nuclear factor kappa-B p65/RELA nuclear transport in endothelial cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7X0"/>
    <dbReference type="Ensembl" id="ENSMODT00000067641.1">
        <property type="protein sequence ID" value="ENSMODP00000055301.1"/>
        <property type="gene ID" value="ENSMODG00000001223.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164241"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001223">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04109">
        <property type="entry name" value="Rab28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000513">
        <property type="entry name" value="ras-related protein Rab-28 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0636">Prenylation</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00039505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00093324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="204" mass="23061" checksum="E6C8B25DBCD9C802" modified="2019-12-11" version="1">MLASEIYQTSLATRFAQEAFGKQYKQTVGLDFFLKRITLPGNLNATLQVWDIGGQTIGGKMLDKYIYGAQGILLVYDITNYQSFENLEDWYNMVKKVNEESETQPLVALVGNKIDLEHMRTVKPDKHLRFCQENGLSSHFVSAKTGDSVFLCFQRVAAEILGIKLNKAEIEQSQRVVKADIVNYNQEPVSKTINPPRSSMCTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7X1</accession>
    <name>A0A5F8H7X1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoredoxin like 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7X1"/>
    <dbReference type="Ensembl" id="ENSMODT00000058241.1">
        <property type="protein sequence ID" value="ENSMODP00000055659.1"/>
        <property type="gene ID" value="ENSMODG00000004441.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161246"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004441">
        <property type="expression patterns" value="Expressed in testis and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029520">
        <property type="entry name" value="RdCVF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47109">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47109:SF1">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="63"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="153" mass="17598" checksum="7C68FEDD52952CDF" modified="2019-12-11" version="1">MTLSTLTHKLLWPKSPQACLRTGLWEPGRTGMATLFTGKILIRNNSDGDEVDTEQELSLRLDNRVLLLYFGAGECPQCQTFAPILKDFFVKLTDEFYVNRASQIALVYISQDQTKEQQDSFLRDMPRKWLFLPFQDELKRASLFPSLLCSSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7X4</accession>
    <name>A0A5F8H7X4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ArfGAP with dual PH domains 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ADAP2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7X4"/>
    <dbReference type="FunCoup" id="A0A5F8H7X4">
        <property type="interactions" value="679"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000056060"/>
    <dbReference type="Ensembl" id="ENSMODT00000068937.1">
        <property type="protein sequence ID" value="ENSMODP00000056060.1"/>
        <property type="gene ID" value="ENSMODG00000019196.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156498"/>
    <dbReference type="InParanoid" id="A0A5F8H7X4"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019196">
        <property type="expression patterns" value="Expressed in lung and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043533">
        <property type="term" value="F:inositol 1,3,4,5 tetrakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13252">
        <property type="entry name" value="PH1_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000080">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037849">
        <property type="entry name" value="PH1_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF6">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="67"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="167"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="392" mass="45440" checksum="49E54B0F6096433C" modified="2019-12-11" version="1">MLEWKRVSSSDSQTPAQGQVSSTCPLDCEALFPSDAPTTTHSCSPKCPLHPSLTRSRFLAFFSPPADPDWASYKLGIFICLNCSGVHRNFPEISRVKSVRLDFWDDSIVEFMTRNGNLCSKAKYEAKVPAFYYIPQSEDCMVLKEQWIRAKYERQEFVASSLTWTFSGNREGLLWKRGRDNGQYLRRKFVLLTREGLLKYYTKEEGKAPKAVISIKDLNATFQTEKIGNPHGLQITYKRDGHTRNLFVYHENGKEIVDWFNAFRAARLHYLKTAFPELPESEQREAFKKRWFALDPQERRLFYYKNPLDAFEQGQVFIGNKEHGYEIHDDVPKGVRGNRWKAGITIVTPERRFVFACPNEKEQREWLESLRHVLALPMTPLNPYATAATGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7X6</accession>
    <name>A0A5F8H7X6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">VARS1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7X6"/>
    <dbReference type="Ensembl" id="ENSMODT00000062960.1">
        <property type="protein sequence ID" value="ENSMODP00000055306.1"/>
        <property type="gene ID" value="ENSMODG00000015204.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157775"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015204">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000119">
        <property type="entry name" value="Putative valine--tRNA ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.380:FF:000002">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000030">
        <property type="entry name" value="valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000008">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="14">
        <location>
            <begin position="89"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="217"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1149"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1212" mass="134457" checksum="D14A7DDEABD0DA48" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7X7</accession>
    <name>A0A5F8H7X7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">SLIT-ROBO Rho GTPase-activating protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7X7"/>
    <dbReference type="Ensembl" id="ENSMODT00000086560.1">
        <property type="protein sequence ID" value="ENSMODP00000055912.1"/>
        <property type="gene ID" value="ENSMODG00000001993.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100014680"/>
    <dbReference type="CTD" id="23380"/>
    <dbReference type="GeneTree" id="ENSGT00950000182824"/>
    <dbReference type="OrthoDB" id="5981864at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001993">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04383">
        <property type="entry name" value="RhoGAP_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11955">
        <property type="entry name" value="SH3_srGAP1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000010">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000006">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000266">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035648">
        <property type="entry name" value="srGAP1/2/3_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12 22 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="F-BAR" evidence="27">
        <location>
            <begin position="22"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="26">
        <location>
            <begin position="486"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="25">
        <location>
            <begin position="729"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="852"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="975" mass="110726" checksum="0CF335CE5466F0F7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7X8</accession>
    <name>A0A5F8H7X8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2-oxoglutarate and iron dependent oxygenase domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">OGFOD3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_007483492.1">
        <property type="nucleotide sequence ID" value="XM_007483430.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7X8"/>
    <dbReference type="Ensembl" id="ENSMODT00000053076.1">
        <property type="protein sequence ID" value="ENSMODP00000056068.1"/>
        <property type="gene ID" value="ENSMODG00000007122.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100022662"/>
    <dbReference type="CTD" id="79701"/>
    <dbReference type="GeneTree" id="ENSGT00390000005895"/>
    <dbReference type="OrthoDB" id="427071at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007122">
        <property type="expression patterns" value="Expressed in endometrium and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039210">
        <property type="entry name" value="OGFOD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650">
        <property type="entry name" value="PROLYL HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="189"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="301" mass="33760" checksum="4D75F18870B3F44E" modified="2019-12-11" version="1">MAPLRRSGSKATEGSSSAGVELAESRRLDSIKKNRVHHESQRKWLKISLLGSSGLLASLLLWSFLNGDDGVTEVLAHHNEILQNRFIEVICSEDYDSHKRFEGCTPRKCGRGITDIVITREEAEQLRRVAEKGLSLGGSEGGASILDLHSGALSFGKHFVNLYRDVRQKIQHTIGQAFDINISSMYLTKPTFFSRINSTEAKTTHDEYWHPHIDKITYGSFDYTSLLYLSDYMKDFGGGRFVFMEEGVNKTVEPRAGRVSFFTSGSENLHRVEKVHWGTRYAITISFTCNPDHGIGDPADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7X9</accession>
    <name>A0A5F8H7X9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat and SOCS box protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ASB15</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7X9"/>
    <dbReference type="Ensembl" id="ENSMODT00000062802.1">
        <property type="protein sequence ID" value="ENSMODP00000056065.1"/>
        <property type="gene ID" value="ENSMODG00000015383.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013482"/>
    <dbReference type="CTD" id="142685"/>
    <dbReference type="GeneTree" id="ENSGT00940000157073"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015383">
        <property type="expression patterns" value="Expressed in heart and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000310">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF187">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX CONTAINING 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="9">
        <location>
            <begin position="541"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="596" mass="67381" checksum="0394C658F3BE1B34" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7Y0</accession>
    <name>A0A5F8H7Y0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase NEDD4-like</fullName>
            <ecNumber evidence="6">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">HECT-type E3 ubiquitin transferase NED4L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">NEDD4L</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7Y0"/>
    <dbReference type="FunCoup" id="A0A5F8H7Y0">
        <property type="interactions" value="1699"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055669"/>
    <dbReference type="Ensembl" id="ENSMODT00000087612.1">
        <property type="protein sequence ID" value="ENSMODP00000055669.1"/>
        <property type="gene ID" value="ENSMODG00000020439.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022149"/>
    <dbReference type="CTD" id="23327"/>
    <dbReference type="GeneTree" id="ENSGT00940000156873"/>
    <dbReference type="InParanoid" id="A0A5F8H7Y0"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020439">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019870">
        <property type="term" value="F:potassium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019871">
        <property type="term" value="F:sodium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903765">
        <property type="term" value="P:negative regulation of potassium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000009">
        <property type="term" value="P:negative regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903783">
        <property type="term" value="P:negative regulation of sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903861">
        <property type="term" value="P:positive regulation of dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060306">
        <property type="term" value="P:regulation of membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase HACE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000006">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000008">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000025">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF443">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WW" evidence="20">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="20">
        <location>
            <begin position="682"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="20">
        <location>
            <begin position="794"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="20">
        <location>
            <begin position="845"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="21">
        <location>
            <begin position="937"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="628"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="720"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="18">
        <location>
            <position position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1272" mass="144885" checksum="248963A11C622B18" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7Y1</accession>
    <name>A0A5F8H7Y1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrosomal protein 295</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000059370.1">
        <property type="protein sequence ID" value="ENSMODP00000055311.1"/>
        <property type="gene ID" value="ENSMODG00000000714.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153123"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000714">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21553:SF26">
        <property type="entry name" value="ALMS MOTIF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21553">
        <property type="entry name" value="ALMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1240"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1334"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1505"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1607"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1745"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1872"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2107"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="650"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1240"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1511"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1608"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1751"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1879"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1905"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1916"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2127"/>
            <end position="2137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2267" mass="260247" checksum="7DF3C59AC1582241" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7Y2</accession>
    <name>A0A5F8H7Y2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LYR motif containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LYRM4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016287275.1">
        <property type="nucleotide sequence ID" value="XM_016431789.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7Y2"/>
    <dbReference type="Ensembl" id="ENSMODT00000052175.1">
        <property type="protein sequence ID" value="ENSMODP00000056073.1"/>
        <property type="gene ID" value="ENSMODG00000042735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100028225"/>
    <dbReference type="CTD" id="57128"/>
    <dbReference type="GeneTree" id="ENSGT00940000157289"/>
    <dbReference type="OrthoDB" id="9443184at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000042735">
        <property type="expression patterns" value="Expressed in blood and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="176" mass="20138" checksum="3645E87B7F4B6785" modified="2019-12-11" version="1">MLSCPEFCLFSLYQTIWVLEPIQGPDRYRRNGNSKMLSPTPNSRTHPRGRGELSPGVPRPLFSPAPPGHVGPPRKGPVCLPHPLPPKMAASSRAQVLDLYRVMLRESSKFASYNYRTYAIRRIREAFRENKNVKDPAQVQILVNKAKRNLEVIQRQCTLREPLNFKAEQETERTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7Y3</accession>
    <name>A0A5F8H7Y3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MMS19</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the CIA complex. In the CIA complex, interacts directly with CIAO2B and CIAO3. Component of the MMXD complex, composed of CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5. Interacts with CIAO2B; the interaction is direct. Interacts with ERCC2/XPD; the interaction is direct. Interacts with ERCC3/XPB and NCOA3/RAC3. Interacts with RTEL1; the interaction mediates the association of RTEL1 with the CIA complex. Interacts with BRIP1. Interacts with KIF4A; the interaction facilitates the transfer of Fe-S clusters to KIF4A to ensure proper localization of KIF4A to the mitotic machinery components. Interacts with CCDC117; the interaction is indirect.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
            <location evidence="2 11">Cytoskeleton</location>
            <location evidence="2 11">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056657488.1">
        <property type="nucleotide sequence ID" value="XM_056801510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7Y3"/>
    <dbReference type="Ensembl" id="ENSMODT00000088336.1">
        <property type="protein sequence ID" value="ENSMODP00000055917.1"/>
        <property type="gene ID" value="ENSMODG00000004099.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100016403"/>
    <dbReference type="CTD" id="64210"/>
    <dbReference type="GeneTree" id="ENSGT00390000015583"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004099">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000114">
        <property type="entry name" value="MMS19 nucleotide excision repair protein homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="14">
        <location>
            <begin position="138"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="13">
        <location>
            <begin position="611"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1066" mass="116642" checksum="254DA2ECA2E3244E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7Y4</accession>
    <name>A0A5F8H7Y4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Regulating synaptic membrane exocytosis 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RIMS2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000068768.1">
        <property type="protein sequence ID" value="ENSMODP00000056070.1"/>
        <property type="gene ID" value="ENSMODG00000005498.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155236"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005498">
        <property type="expression patterns" value="Expressed in cerebellum and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04031">
        <property type="entry name" value="C2A_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04028">
        <property type="entry name" value="C2B_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06714">
        <property type="entry name" value="PDZ_RIM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000001">
        <property type="entry name" value="Regulating synaptic membrane exocytosis 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000003">
        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000003">
        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000044">
        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054386">
        <property type="entry name" value="RIM_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF15">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22601">
        <property type="entry name" value="RIM2a_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RabBD" evidence="15">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="84"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="638"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="791"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1554"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="732"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="924"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="980"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1077"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1246"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1378"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1458"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="735"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="980"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1077"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1170"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1197"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1246"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1269"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1314"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1336"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1378"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1463"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1708" mass="194074" checksum="61D8B56279354D44" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H891</accession>
    <name>A0A5F8H891_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Rap guanine nucleotide exchange factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RAPGEF6</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RAPGEF2 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000063433.1">
        <property type="protein sequence ID" value="ENSMODP00000055416.1"/>
        <property type="gene ID" value="ENSMODG00000014131.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158124"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014131">
        <property type="expression patterns" value="Expressed in forelimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06755">
        <property type="entry name" value="PDZ_RapGEF2_RapGEF6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01785">
        <property type="entry name" value="RA_PDZ-GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000001">
        <property type="entry name" value="Rap guanine nucleotide exchange factor (GEF) 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000024">
        <property type="entry name" value="rap guanine nucleotide exchange factor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.870.10:FF:000001">
        <property type="entry name" value="rap guanine nucleotide exchange factor 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000019">
        <property type="entry name" value="rap guanine nucleotide exchange factor 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000040">
        <property type="entry name" value="rap guanine nucleotide exchange factor 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45161">
        <property type="entry name" value="CYTOSKELETON-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45161:SF4">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="281"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="15">
        <location>
            <begin position="413"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="531"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="14">
        <location>
            <begin position="750"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="11">
        <location>
            <begin position="861"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1225"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1509"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1076"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1238"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1276"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1522"/>
            <end position="1534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1547" mass="173797" checksum="CD36F9E37DF9B8BF" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H892</accession>
    <name>A0A5F8H892_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H892"/>
    <dbReference type="Ensembl" id="ENSMODT00000069510.1">
        <property type="protein sequence ID" value="ENSMODP00000056188.1"/>
        <property type="gene ID" value="ENSMODG00000009452.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234540"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009452">
        <property type="expression patterns" value="Expressed in blood and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16842">
        <property type="entry name" value="Ig_SLAM-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000820">
        <property type="entry name" value="SLAM family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015631">
        <property type="entry name" value="CD2/SLAM_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080">
        <property type="entry name" value="SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080:SF18">
        <property type="entry name" value="SLAM FAMILY MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Immunoglobulin V-set" evidence="12">
        <location>
            <begin position="62"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="173" mass="18824" checksum="91087FBC488A3DF9" modified="2019-12-11" version="1">MSKGQGTNVFTSGPILILNWKPGDHDLNYTCTARNPVSNSSRTVLAKEFCAGSTASRENNAPVVVTGILGESAILPADIPDKNKIDNINWASRTPVAVVTPEGTSVNIITTHLNYKGRLNVSSKTYDLQINHLKMEDAGFYRADINLKTSSTSTTITKNYTLQIYSKTMIVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H894</accession>
    <name>A0A5F8H894_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PEX5-related protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">PEX5-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peroxin-5-related protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Tetratricopeptide repeat-containing Rab8b-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PEX5L</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007502045.1">
        <property type="nucleotide sequence ID" value="XM_007501983.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H894"/>
    <dbReference type="Ensembl" id="ENSMODT00000064812.1">
        <property type="protein sequence ID" value="ENSMODP00000055784.1"/>
        <property type="gene ID" value="ENSMODG00000021298.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100010787"/>
    <dbReference type="CTD" id="51555"/>
    <dbReference type="GeneTree" id="ENSGT00940000155931"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021298">
        <property type="expression patterns" value="Expressed in cerebellum and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000012">
        <property type="entry name" value="PEX5-related protein isoform 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF1">
        <property type="entry name" value="PEX5-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="60"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="122"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="567" mass="63170" checksum="8A1A85B57DCFE883" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H895</accession>
    <name>A0A5F8H895_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear pore complex protein Nup214</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">214 kDa nucleoporin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nucleoporin Nup214</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NUP214</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Part of the nuclear pore complex (NPC). Interacts with NUP88. Interacts with ZFP36; this interaction increases upon lipopolysaccharide (LPS) stimulation. Interacts with DDX19. Interacts with XPO1. Interacts with XPO5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000068877.1">
        <property type="protein sequence ID" value="ENSMODP00000056022.1"/>
        <property type="gene ID" value="ENSMODG00000012396.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153253"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012396">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000142">
        <property type="entry name" value="Nuclear pore complex protein Nup214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="15">
        <location>
            <begin position="35"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="381"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1142"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1309"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1350"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1377"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1716"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1151"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1392"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1425"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1452"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1474"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1733"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1749"/>
            <end position="1758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1758" mass="183565" checksum="4C60F2B0549227FE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H896</accession>
    <name>A0A5F8H896_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 35 member A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC35A1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H896"/>
    <dbReference type="Ensembl" id="ENSMODT00000056566.1">
        <property type="protein sequence ID" value="ENSMODP00000055421.1"/>
        <property type="gene ID" value="ENSMODG00000018310.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182827"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018310">
        <property type="expression patterns" value="Expressed in endometrium and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="311" mass="34085" checksum="E35C2D9E57181727" modified="2019-12-11" version="1">MVFGGRSHSALRRAGTKRSVYRLALVRLGLLRRDGCPERETGSVGRFKTSLKENVLGSPKELMKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRSLSKLQWISVFMLCAGVTLVQWKPAQATKVLVEQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIVVTLAAVYMSDGAEVIEKGFFHGYTYYVWFVILLASVGGLYTSIVVKYTDNIMKGFSAAAAIVLSTIASVILFGLQITLNFALGTLLVCISIYLYGLPREDTTVVQGEETTSKERLIHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H897</accession>
    <name>A0A5F8H897_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquitin associated and SH3 domain containing A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">UBASH3A</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H897"/>
    <dbReference type="Ensembl" id="ENSMODT00000084876.1">
        <property type="protein sequence ID" value="ENSMODP00000056193.1"/>
        <property type="gene ID" value="ENSMODG00000021021.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160841"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021021">
        <property type="expression patterns" value="Expressed in blood and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="139" mass="16174" checksum="55896B84D7CD081D" modified="2019-12-11" version="1">GHKENLKEKVTVPKEFAISWRNASNHVQRRCIQDKFEKISYGKESHQGTLGKVSCRRQKALAATGRRTVEEASEWLHFHYNDPSLDDPIPQEYALYLCPTGPLLEKLQDFWRESKRQCGKNRAHETFPHVTLCDFFTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H898</accession>
    <name>A0A5F8H898_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein phosphatase 2 scaffold subunit Abeta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PPP2R1B</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H898"/>
    <dbReference type="Ensembl" id="ENSMODT00000062822.1">
        <property type="protein sequence ID" value="ENSMODP00000056190.1"/>
        <property type="gene ID" value="ENSMODG00000014475.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183066"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014475">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="173"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="256"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="288"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="371"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="449"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="488"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="527"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="556" mass="61149" checksum="586FAA004BF95203" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H899</accession>
    <name>A0A5F8H899_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GNA11</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22. Interacts with NTSR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H899"/>
    <dbReference type="Ensembl" id="ENSMODT00000086903.1">
        <property type="protein sequence ID" value="ENSMODP00000056027.1"/>
        <property type="gene ID" value="ENSMODG00000019142.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161033"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019142">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000654">
        <property type="entry name" value="Gprotein_alpha_Q"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF328">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00442">
        <property type="entry name" value="GPROTEINAQ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0564">Palmitate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 19" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="177"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU369122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="356" mass="41785" checksum="86465CF3DEC527AF" modified="2025-10-08" version="2">MSMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSEEDKRGFTKLVYQNIFTAMQSMIRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLWNDPGIQECYDRRREYQLSDSAKYYLTDVDRIATTGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F6YZ84</accession>
    <name>F6YZ84_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nebulette</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NEBL</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F6YZ84"/>
    <dbReference type="FunCoup" id="F6YZ84">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000011714.5">
        <property type="protein sequence ID" value="ENSMODP00000011494.4"/>
        <property type="gene ID" value="ENSMODG00000009210.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100019946"/>
    <dbReference type="CTD" id="10529"/>
    <dbReference type="eggNOG" id="KOG1702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156390"/>
    <dbReference type="HOGENOM" id="CLU_014106_0_0_1"/>
    <dbReference type="InParanoid" id="F6YZ84"/>
    <dbReference type="OrthoDB" id="191061at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009210">
        <property type="expression patterns" value="Expressed in heart and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031005">
        <property type="term" value="F:filamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071691">
        <property type="term" value="P:cardiac muscle thin filament assembly"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd11935">
        <property type="entry name" value="SH3_Nebulette_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000007">
        <property type="entry name" value="nebulin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055297">
        <property type="entry name" value="NEBU/NEBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035631">
        <property type="entry name" value="Nebulette_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11039:SF48">
        <property type="entry name" value="NEBULETTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11039">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="953"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011494.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1013" mass="116277" checksum="328B0690C6782CFE" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F7BPN9</accession>
    <name>F7BPN9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAM3 metabolism regulating signaling molecule A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FAM3A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007506953.1">
        <property type="nucleotide sequence ID" value="XM_007506891.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7BPN9"/>
    <dbReference type="Ensembl" id="ENSMODT00000011459.3">
        <property type="protein sequence ID" value="ENSMODP00000011241.2"/>
        <property type="gene ID" value="ENSMODG00000009016.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022677"/>
    <dbReference type="CTD" id="60343"/>
    <dbReference type="eggNOG" id="ENOG502QUEU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183004"/>
    <dbReference type="HOGENOM" id="CLU_099478_1_0_1"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009016">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13940">
        <property type="entry name" value="ILEI_FAM3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039220">
        <property type="entry name" value="FAM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039475">
        <property type="entry name" value="ILEI_FAM3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14592">
        <property type="entry name" value="UNCHARACTERIZED FAM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ILEI/PANDER" evidence="8">
        <location>
            <begin position="127"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011241.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="255" mass="27899" checksum="8E97F838304F534C" modified="2013-01-09" version="2">MRVAGPLRIVVLILTAGLTWILGSILLGSHGSSFSRIQQLFSNPENAVTTVAERAFSLWSVQPSPEASHPAGHDKPRARKYKCGLPQPCPEQHLAFRVVSGAANVIGPKICLEDKMLMSSVKDNVGRGLNIALVNGVNGELLEARSFDMWAGDVNDLLKFIRPLHEGTLVFVASYDDPATKMNEETRKIFSELGSSNAKELAFRDSWVFVGAKGVQDKSPFEQHVKNSKSTNKYEGWPEALELEGCIPQRTVGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>F7CRE5</accession>
    <name>F7CRE5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TCP1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the chaperonin-containing T-complex (TRiC), a hexadecamer composed of two identical back-to-back stacked rings enclosing a protein folding chamber. Each ring is made up of eight different subunits: TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A/CCT6, CCT7, CCT8. Interacts with PACRG. Interacts with GBA1. Interacts with DLEC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7CRE5"/>
    <dbReference type="Ensembl" id="ENSMODT00000009459.3">
        <property type="protein sequence ID" value="ENSMODP00000009278.3"/>
        <property type="gene ID" value="ENSMODG00000007478.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074878"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007478">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000040">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000009278.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="551" mass="60003" checksum="AB74B95DC01BE1D6" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F7CSP5</accession>
    <name>F7CSP5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ER membrane protein complex subunit 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EMC9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F7CSP5"/>
    <dbReference type="Ensembl" id="ENSMODT00000004353.2">
        <property type="protein sequence ID" value="ENSMODP00000004263.2"/>
        <property type="gene ID" value="ENSMODG00000003488.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006738"/>
    <dbReference type="HOGENOM" id="CLU_087337_0_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003488">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF12">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000004263.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="122" mass="14052" checksum="68899329CA13DEA1" modified="2019-12-11" version="2">PLIYVLPSPGPLALKIAGRIAEFFPGAVLIMLDNRKLVPQTRVPPIIVLEPRDRRWVPKDKNLVMWRDWEESRQLLQALLEGRAHRLLVDFDAHLDDIRRDWTNQQLNTEISQWVAAANGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F7D4P3</accession>
    <name>F7D4P3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cis-aconitate decarboxylase</fullName>
            <ecNumber evidence="12">4.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Aconitate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Aconitate decarboxylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cis-aconitic acid decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Immune-responsive gene 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ACOD1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>cis-aconitate + H(+) = itaconate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15253"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16383"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17240"/>
            <dbReference type="EC" id="4.1.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15254"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.6" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="F7D4P3"/>
    <dbReference type="Ensembl" id="ENSMODT00000001385.2">
        <property type="protein sequence ID" value="ENSMODP00000001357.2"/>
        <property type="gene ID" value="ENSMODG00000001141.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QVEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015700"/>
    <dbReference type="HOGENOM" id="CLU_026574_2_2_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001141">
        <property type="expression patterns" value="Expressed in lung and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047613">
        <property type="term" value="F:aconitate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002760">
        <property type="term" value="P:positive regulation of antimicrobial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072573">
        <property type="term" value="P:tolerance induction to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4100.10:FF:000002">
        <property type="entry name" value="Aconitate decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000002">
        <property type="entry name" value="Aconitate decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF11">
        <property type="entry name" value="CIS-ACONITATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="18">
        <location>
            <begin position="8"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="19">
        <location>
            <begin position="274"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000001357.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="467" mass="51520" checksum="8415EC29E54DF722" modified="2019-12-11" version="2">FPFKSVTESFASIIQGLKVQHLTDRVIQRSKRMILDTLGVGLLGTNTEVFHKTLQYSKIFSTDVSSCVWGQPDLQLPPVYAAFVNGVAVHSMDFDDTWHPATHPSGPVLPVLLALSEAFPQNPRFSGLDLLLAFNVGIEVQGRLMHFSKQASDIPKRFHPPAIVGTLGSAAAAAKFLGLDQTKCREAIAIAVSYAGAPLANAATQTKPLHVGNAARHGLEAALLALLGLQGNQKILDTEAGFGAFYSKYAPQALPALESYTFLLDQQGIAIKRFPSHLGTHWVADAAASVRKYLLPNDRIKRIVLRIPDVKYVNRPFPVSEHEARHSFQFIACTMLLDGGISVHSFHDSQIGRLQLRELLNKVELEYPPDNHPSFDTLYCEVSVTLENGNCFTERCDTFYGHWRKPLHQEDLEEKFRVNSSTVLSSEAVEGIIRTVDRLEDLEDCSLLTTFLKGQEVLGSNSISDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>F7DUH7</accession>
    <name>F7DUH7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 345-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC103092424</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7DUH7"/>
    <dbReference type="Ensembl" id="ENSMODT00000032432.3">
        <property type="protein sequence ID" value="ENSMODP00000030861.3"/>
        <property type="gene ID" value="ENSMODG00000037327.1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155965"/>
    <dbReference type="HOGENOM" id="CLU_002678_17_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000037327">
        <property type="expression patterns" value="Expressed in ovary and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7DUH7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002649">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002079">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002264">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002519">
        <property type="entry name" value="zinc finger protein 252-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="105"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="657"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="685"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="741"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="797"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="853"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="881"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="909"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="937"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000030861.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="964" mass="109705" checksum="E73059B396CE1138" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F7EZ76</accession>
    <name>F7EZ76_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KH domain-containing RNA-binding protein QKI</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein quaking</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">QKI</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homodimer; does not require RNA to homodimerize. Able to heterodimerize with BICC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7EZ76"/>
    <dbReference type="Ensembl" id="ENSMODT00000008147.3">
        <property type="protein sequence ID" value="ENSMODP00000007984.4"/>
        <property type="gene ID" value="ENSMODG00000006434.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155310"/>
    <dbReference type="HOGENOM" id="CLU_046595_2_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006434">
        <property type="expression patterns" value="Expressed in forelimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22465">
        <property type="entry name" value="KH-I_Hqk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000055">
        <property type="entry name" value="protein quaking isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032367">
        <property type="entry name" value="Quaking_NLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16551">
        <property type="entry name" value="Quaking_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="66"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000007984.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="326" mass="35973" checksum="3618377C75BFC59E" modified="2019-12-11" version="3">MKIKFVNFMPLPIDLLFFYFLAFSALEGVFLTLEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAATAQAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLGAVATKVRRHDMRVHPYQRIVTADRAATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4R0</accession>
    <name>A0A5F8G4R0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cerebral endothelial cell adhesion molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CERCAM</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4R0"/>
    <dbReference type="FunCoup" id="A0A5F8G4R0">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042463"/>
    <dbReference type="Ensembl" id="ENSMODT00000057374.1">
        <property type="protein sequence ID" value="ENSMODP00000042463.1"/>
        <property type="gene ID" value="ENSMODG00000005999.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234558"/>
    <dbReference type="InParanoid" id="A0A5F8G4R0"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005999">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF9">
        <property type="entry name" value="INACTIVE GLYCOSYLTRANSFERASE 25 FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="4">
        <location>
            <begin position="401"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="675" mass="77023" checksum="D10D707C87AFF0E7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4R2</accession>
    <name>A0A5F8G4R2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 26 member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SLC26A8</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4R2"/>
    <dbReference type="Ensembl" id="ENSMODT00000078504.1">
        <property type="protein sequence ID" value="ENSMODP00000042429.1"/>
        <property type="gene ID" value="ENSMODG00000013715.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286920"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013715">
        <property type="expression patterns" value="Expressed in spermatocyte and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="474"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="688" mass="77636" checksum="3DFEDD6FFE3732A2" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4R3</accession>
    <name>A0A5F8G4R3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger ZZ-type and EF-hand domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ZZEF1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000082650.1">
        <property type="protein sequence ID" value="ENSMODP00000042435.1"/>
        <property type="gene ID" value="ENSMODG00000020584.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155045"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020584">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08667">
        <property type="entry name" value="APC10-ZZEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02343">
        <property type="entry name" value="ZZ_EF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040099">
        <property type="entry name" value="ZZEF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047052">
        <property type="entry name" value="ZZEF1_APC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041986">
        <property type="entry name" value="ZZEF1_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22772">
        <property type="entry name" value="NOVEL ZZ TYPE ZINC FINGER DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22772:SF4">
        <property type="entry name" value="ZINC FINGER ZZ-TYPE AND EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="227"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="1785"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="1834"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1469"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1516"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2392"/>
            <end position="2419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1476"/>
            <end position="1487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2924" mass="320876" checksum="1E705BC8184C9C11" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4R8</accession>
    <name>A0A5F8G4R8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Splicing factor proline and glutamine rich</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SFPQ</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056651105.1">
        <property type="nucleotide sequence ID" value="XM_056795127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4R8"/>
    <dbReference type="Ensembl" id="ENSMODT00000074789.1">
        <property type="protein sequence ID" value="ENSMODP00000042440.1"/>
        <property type="gene ID" value="ENSMODG00000017937.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100031251"/>
    <dbReference type="CTD" id="6421"/>
    <dbReference type="GeneTree" id="ENSGT00940000156221"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017937">
        <property type="expression patterns" value="Expressed in hindlimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042382">
        <property type="term" value="C:paraspeckles"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12948">
        <property type="entry name" value="NOPS_PSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12587">
        <property type="entry name" value="RRM1_PSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12590">
        <property type="entry name" value="RRM2_PSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000043">
        <property type="entry name" value="paraspeckle component 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000126">
        <property type="entry name" value="paraspeckle component 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012975">
        <property type="entry name" value="NOPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034526">
        <property type="entry name" value="PSF_NOPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034525">
        <property type="entry name" value="PSF_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08075">
        <property type="entry name" value="NOPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="291"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="365"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="492"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="662" mass="70669" checksum="42814D64CAA48BEE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4S4</accession>
    <name>A0A5F8G4S4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Forkhead box P1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FOXP1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4S4"/>
    <dbReference type="FunCoup" id="A0A5F8G4S4">
        <property type="interactions" value="1950"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042445"/>
    <dbReference type="Ensembl" id="ENSMODT00000085642.1">
        <property type="protein sequence ID" value="ENSMODP00000042445.1"/>
        <property type="gene ID" value="ENSMODG00000003884.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159892"/>
    <dbReference type="InParanoid" id="A0A5F8G4S4"/>
    <dbReference type="OMA" id="HEEHSHN"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003884">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042118">
        <property type="term" value="P:endothelial cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042116">
        <property type="term" value="P:macrophage activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042117">
        <property type="term" value="P:monocyte activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060766">
        <property type="term" value="P:negative regulation of androgen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002903">
        <property type="term" value="P:negative regulation of B cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036035">
        <property type="term" value="P:osteoclast development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050861">
        <property type="term" value="P:positive regulation of B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010595">
        <property type="term" value="P:positive regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048661">
        <property type="term" value="P:positive regulation of smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000341">
        <property type="term" value="P:regulation of chemokine (C-X-C motif) ligand 2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900424">
        <property type="term" value="P:regulation of defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901509">
        <property type="term" value="P:regulation of endothelial tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032651">
        <property type="term" value="P:regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032655">
        <property type="term" value="P:regulation of interleukin-12 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901256">
        <property type="term" value="P:regulation of macrophage colony-stimulating factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045655">
        <property type="term" value="P:regulation of monocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032680">
        <property type="term" value="P:regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000005">
        <property type="entry name" value="Forkhead box P1, isoform CRA_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032354">
        <property type="entry name" value="FOXP-CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16159">
        <property type="entry name" value="FOXP-CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="465"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="465"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="627"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="693" mass="77266" checksum="7D182E480C2881A4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4S5</accession>
    <name>A0A5F8G4S5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 26 member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SLC26A8</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4S5"/>
    <dbReference type="Ensembl" id="ENSMODT00000067645.1">
        <property type="protein sequence ID" value="ENSMODP00000042452.1"/>
        <property type="gene ID" value="ENSMODG00000013715.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286920"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013715">
        <property type="expression patterns" value="Expressed in spermatocyte and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="529"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="868" mass="98815" checksum="83C3B56EBDE97313" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4S6</accession>
    <name>A0A5F8G4S6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pulmonary surfactant-associated protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100016579</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex of 6 set of homotrimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Surface film</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the SFTPA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4S6"/>
    <dbReference type="Ensembl" id="ENSMODT00000087921.1">
        <property type="protein sequence ID" value="ENSMODP00000042444.1"/>
        <property type="gene ID" value="ENSMODG00000037815.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156653"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000037815">
        <property type="expression patterns" value="Expressed in liver and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007585">
        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000199">
        <property type="entry name" value="Mannose binding lectin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF13">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-0305">Gaseous exchange</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0767">Surface film</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023903706" description="Pulmonary surfactant-associated protein A" evidence="15">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="16">
        <location>
            <begin position="139"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="252" mass="27712" checksum="62DE22F9AD7E58CE" modified="2019-12-11" version="1">MMVLLPLLSLLLLEWALIGSCSEKGGNDEQPSTYSDTYYHGPWIAGRPGRDGRDGRDGAKGEKGDPGEVLNGMQGCPANVGHSGSPGPQGPPGIKGMKGEPGGMHSSLIEERLNMTSYLTARLLKLSKALTFYGNMVHLGEKFYVTTGQSFNFFMINKTCQEMGGAVATPRNKEENAAIMKLVVRHNTHAFLALREGIIGKFYYLDGSPLKYTNWYSGRPDGQGQENCVEMYTDGTWNDRDCSYYRLGICEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4S8</accession>
    <name>A0A5F8G4S8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Katanin p60 ATPase-containing subunit A-like 2</fullName>
            <shortName evidence="8">Katanin p60 subunit A-like 2</shortName>
            <ecNumber evidence="8">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">p60 katanin-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">KATNAL2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
            <location evidence="1 8">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Spindle</location>
        </subcellularLocation>
        <text evidence="8">Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4S8"/>
    <dbReference type="FunCoup" id="A0A5F8G4S8">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042436"/>
    <dbReference type="Ensembl" id="ENSMODT00000072551.1">
        <property type="protein sequence ID" value="ENSMODP00000042436.1"/>
        <property type="gene ID" value="ENSMODG00000003358.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100018387"/>
    <dbReference type="CTD" id="83473"/>
    <dbReference type="GeneTree" id="ENSGT00940000157302"/>
    <dbReference type="InParanoid" id="A0A5F8G4S8"/>
    <dbReference type="OMA" id="MKTQGKY"/>
    <dbReference type="OrthoDB" id="191529at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003358">
        <property type="expression patterns" value="Expressed in spermatocyte and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000048">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000434">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03025">
        <property type="entry name" value="Katanin_p60_AL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027497">
        <property type="entry name" value="Katanin_p60_AL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF78">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="313"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="321"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="565" mass="63577" checksum="C25F6D43BC7930E5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4T2</accession>
    <name>A0A5F8G4T2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec1 family domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SCFD1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4T2"/>
    <dbReference type="Ensembl" id="ENSMODT00000057900.1">
        <property type="protein sequence ID" value="ENSMODP00000042455.1"/>
        <property type="gene ID" value="ENSMODG00000017563.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074845"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017563">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.60:FF:000002">
        <property type="entry name" value="Sec1 family domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="581" mass="65901" checksum="5B76A968A98D377F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4T3</accession>
    <name>A0A5F8G4T3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Major facilitator superfamily domain-containing protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MFSD12</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine(in) = L-cysteine(out)</text>
            <dbReference type="Rhea" id="RHEA:29655"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29656"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Melanosome membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007489237.1">
        <property type="nucleotide sequence ID" value="XM_007489175.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4T3"/>
    <dbReference type="Ensembl" id="ENSMODT00000082870.1">
        <property type="protein sequence ID" value="ENSMODP00000042441.1"/>
        <property type="gene ID" value="ENSMODG00000006897.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100011002"/>
    <dbReference type="CTD" id="126321"/>
    <dbReference type="GeneTree" id="ENSGT00390000005318"/>
    <dbReference type="OrthoDB" id="1730117at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006897">
        <property type="expression patterns" value="Expressed in lung and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043474">
        <property type="term" value="P:pigment metabolic process involved in pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17491">
        <property type="entry name" value="MFS_MFSD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000206">
        <property type="entry name" value="Major facilitator superfamily domain containing 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000219">
        <property type="entry name" value="major facilitator superfamily domain-containing protein 12 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="473" mass="51556" checksum="1677F0A3F3C0A19E" modified="2019-12-11" version="1">MAEPGLPLVARLSYSVGHFLNDLCASMWFTYLLLYLHSVQGYSSWGAGILLLLGQLADGVCTPLVGYEADHSGGCCGRYGPRKSWHLVGTFCVLLSFPFIFNPCLGCTASTAEWAAIIYYAPFIVIFQFGWAATQISHLSLIPELVTNDHEKVELTAFRYAFTVVANIAVYGAAWLLLHFQGSHSESPDSGPGDQLGLQDVPVFRNLSLMVVCVGAVFSLLFHLGTRERRRPGPEEPSEHSPLLPPAAQPRLLWKHWLREPSFYQVGLLYMSTRLIVNLSQTYMAMYLTYSLSLPKKFIATIPLVMYVSGFFSSFFMKPVNKRIGRNLTYFVGLLVILAFASWVALANLLGPAVYGAAVLLGIGSATILVMSLSMTADLIGSHTNSGAFVYGAMSFTDKVANGLAVMAIQSLYPCSSDLCCAACMGFYHWVMVAVTGGVGVAAALCLCSIFLWPIQVRFFSRTSRTVPDGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4T6</accession>
    <name>A0A5F8G4T6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LYR motif containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LYRM1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4T6"/>
    <dbReference type="Ensembl" id="ENSMODT00000078695.1">
        <property type="protein sequence ID" value="ENSMODP00000042462.1"/>
        <property type="gene ID" value="ENSMODG00000007076.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006695"/>
    <dbReference type="OMA" id="KNWQSAS"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007076">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd20261">
        <property type="entry name" value="Complex1_LYR_LYRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045294">
        <property type="entry name" value="Complex1_LYR_LYRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040330">
        <property type="entry name" value="LYRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14273">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14273:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023897947" evidence="2">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="145" mass="16946" checksum="8815DD3D76122830" modified="2019-12-11" version="1">MVIHLVLAASIIFPVRIRSCVPKMTTATRQEVLGLYRKIFRLARRWHAASGQMEDTIREKQYIINEARILFQKNKNLTDSELIKQCIDECTARIEIGLHYQIPYPRPIHLPPTALSPLQSRGFQNQEKLRKLSRPLYLKSHDEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4T9</accession>
    <name>A0A5F8G4T9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">von Willebrand factor A domain-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">INTS14</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the Integrator complex, composed of core subunits INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L, INTS12, INTS13, INTS14 and INTS15. The core complex associates with protein phosphatase 2A subunits PPP2CA and PPP2R1A, to form the Integrator-PP2A (INTAC) complex. INTS14 is part of the tail subcomplex, composed of INTS10, INTS13, INTS14 and INTS15.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4T9"/>
    <dbReference type="Ensembl" id="ENSMODT00000085261.1">
        <property type="protein sequence ID" value="ENSMODP00000042460.1"/>
        <property type="gene ID" value="ENSMODG00000009876.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009486"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009876">
        <property type="expression patterns" value="Expressed in hindlimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039841">
        <property type="entry name" value="INTS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045814">
        <property type="entry name" value="IntS14_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046471">
        <property type="entry name" value="IntS14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532:SF3">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19435">
        <property type="entry name" value="IntS14_b-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20504">
        <property type="entry name" value="IntS14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 beta-barrel" evidence="6">
        <location>
            <begin position="173"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 C-terminal" evidence="7">
        <location>
            <begin position="368"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="482" mass="53643" checksum="8A793A59D031B5BA" modified="2019-12-11" version="1">MPTVVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQVVLVTDGCLGIGRGSLRHSLATHNQRSDNNRFPLPFPFPSKLYIMCMANLEELQSSESLDCLEQLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTSDVQVFPRPEPFIIDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNREGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLSHAARQLKLASTGTSDYAAYDHNITPLQTDFSGSSTERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G530</accession>
    <name>A0A5F8G530_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="12">MAD homolog</shortName>
            <shortName evidence="12">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SMAD4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G530"/>
    <dbReference type="Ensembl" id="ENSMODT00000058186.1">
        <property type="protein sequence ID" value="ENSMODP00000042598.1"/>
        <property type="gene ID" value="ENSMODG00000010995.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157435"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010995">
        <property type="expression patterns" value="Expressed in hindlimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10492">
        <property type="entry name" value="MH1_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10498">
        <property type="entry name" value="MH2_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF63">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="15">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="16">
        <location>
            <begin position="225"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="438" mass="48132" checksum="8785B8AAD04D9EB2" modified="2019-12-11" version="1">MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSSAPSSMLVKDEYVPDFEGQPSLSTEGHSIQTIQHPPSNRASSETYPAMLAPSESNTTSTTNFPNIPVASTTPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G532</accession>
    <name>A0A5F8G532_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G532"/>
    <dbReference type="Ensembl" id="ENSMODT00000078072.1">
        <property type="protein sequence ID" value="ENSMODP00000042555.1"/>
        <property type="gene ID" value="ENSMODG00000049044.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155297"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000049044">
        <property type="expression patterns" value="Expressed in cerebellum and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005003">
        <property type="term" value="F:ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10476">
        <property type="entry name" value="EphR_LBD_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1770:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000004">
        <property type="entry name" value="Ephrin type-B receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034231">
        <property type="entry name" value="EphB1_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001426">
        <property type="entry name" value="Tyr_kinase_rcpt_V_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF17">
        <property type="entry name" value="EPHRIN TYPE-B RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25599">
        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00790">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00791">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Eph LBD" evidence="13">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="272" mass="30675" checksum="BB7E2E53CF1A62B6" modified="2019-12-11" version="1">MDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQVCNVFEPNQNNWLLTTFIHRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSVIATKKSAFWTEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAIFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRCTCKAGYEPENNVVCKGVKCPQCFMSSDLRMYTFGIHRGHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G538</accession>
    <name>A0A5F8G538_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Aldehyde oxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="15">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000086005.1">
        <property type="protein sequence ID" value="ENSMODP00000042567.1"/>
        <property type="gene ID" value="ENSMODG00000041712.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183114"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000041712">
        <property type="expression patterns" value="Expressed in spermatid and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000025">
        <property type="entry name" value="Aldehyde oxidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="16">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="168"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="1207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="713"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="744"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="858"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="860"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1025"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1247" mass="137531" checksum="62051D30BE338C35" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G539</accession>
    <name>A0A5F8G539_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase OMA1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Overlapping with the m-AAA protease 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">OMA1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooligomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G539"/>
    <dbReference type="Ensembl" id="ENSMODT00000077337.1">
        <property type="protein sequence ID" value="ENSMODP00000042608.1"/>
        <property type="gene ID" value="ENSMODG00000003354.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007027"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003354">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="13">
        <location>
            <begin position="331"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="491" mass="55726" checksum="9B86EBB7D8F2CE33" modified="2019-12-11" version="1">MNTICGLQSARRNCVFFWLRSLTHWKEPPRRCWSLVEKSPPRGPAHCVGGRWLGRSLWKSPGLAHVLRGSSPFSRSRDHGQGPPLSAQSRDMCKRMSSCAGGPRSSLRQGLLRGGAERALSGFIPATRKEDRSHFHTSLPTRAAPVPLLWVILKPAQKLLAIIVGRGIRKWWQALPPNKKELFKGSLKKNKWKLFLGMSGLGVLFVVFYFTHLEESPVTGRRQLLVLGKEHMMKLSQMEYDLWMEEFKNDLLPEKDPRYLAVKKVFQGLVESNRDIPGISEFRWLLHVVDRPDGNAFVLPAEKASLVHLWDFLGLIFLTMIWAVCPQDSLAILAQWIQSKLQEYVFYRPYSRALEAEADRVGLQFAAKACADVRASSVFWQQMELAVMLQGQPKLPEWLSTHPSHGNRTEHLDRLIPQAIKIRESCNCPPLSGPDPRLVFMLTKKHFLEVTEGENQSIPGTLVQKHKTDSLPIQKKEAIPLAFMADKRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G540</accession>
    <name>A0A5F8G540_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDB1 and CUL4 associated factor 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DCAF7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G540"/>
    <dbReference type="SMR" id="A0A5F8G540"/>
    <dbReference type="Ensembl" id="ENSMODT00000065012.1">
        <property type="protein sequence ID" value="ENSMODP00000042536.1"/>
        <property type="gene ID" value="ENSMODG00000009994.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006939"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009994">
        <property type="expression patterns" value="Expressed in spermatocyte and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="142" mass="16340" checksum="A41A8991ACFDC698" modified="2019-12-11" version="1">MSLHGKRKEIYKYEAPWTVYAMNWSVRPDKRFRLALGSFVEEYNNKVVILDVRVPCTPVARLNNHRACVNGIAWAPHSSCHICTAADDHQALIWDIQQMPRAIEDPILAYTAEGEINNVQWASTQPDWIAICYNNCLEILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G541</accession>
    <name>A0A5F8G541_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">WDR41</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the C9orf72-SMCR8 complex, at least composed of C9orf72, SMCR8 and WDR41. The complex is formed of two protomers, each individually consisting of one molecule each of C9orf72, SMCR8 and WDR41. The protomers homodimerize via an interaction between C9orf72 (via C-terminus) and SMCR8 (via N-terminus). Within each protomer SMCR8 (via DENN domain) acts as a bridging protein between WDR41 (via C-terminus and N-terminus) and C9orf72 (via C-terminus). The C9orf72-SMCR8 complex associates with the ULK1/ATG1 kinase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G541"/>
    <dbReference type="FunCoup" id="A0A5F8G541">
        <property type="interactions" value="697"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042572"/>
    <dbReference type="Ensembl" id="ENSMODT00000065067.1">
        <property type="protein sequence ID" value="ENSMODP00000042572.1"/>
        <property type="gene ID" value="ENSMODG00000019738.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017026"/>
    <dbReference type="InParanoid" id="A0A5F8G541"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019738">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000564">
        <property type="entry name" value="WD repeat domain 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040102">
        <property type="entry name" value="WDR41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22805:SF2">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22805">
        <property type="entry name" value="WDR41-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25178">
        <property type="entry name" value="Beta-prop_WDR41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="319"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="461" mass="51981" checksum="D6D7BE5D3C331AC2" modified="2019-12-11" version="1">MLRWLIGGGREPQGLAEKYPVQSIGEEQTQNPYTELLVLKAHHDIVRFLVQLDDYRFASAGDDGIVFLWNAQTGEKIFELHGHTQKITAITAFPSLASCEEKRQMILTASADRTVIIWDCDTGKQVQKVSCFHSTVKCLTVLQRLDVWLSGGSDLCVWNRELDLLCKTSHLFDTGISALIELPKNCVAAAVGKELIIFRLIASTDESLGWDVQEVKRLLDHQDNILSLVNINDLSFVTGSHVGELIVWDALDWTMQAYECNFWDPSLQLDTQQEIKLCQKPNEISIHHFTCDEEYLFAAVGRGLYVYNLQMKRMIACQKTAHDSTVLHIVTLPNRQLISCSEDGSVRIWELREKQQLTSEPVPTGFFNMWGFGRVNKSANQTIKKPQENATVCSLELIGDLIGHSSSVEVGLLLVRKGKSNGEGEWYCRKGAALGIQESFKLPHMCDLGQITQCRPWFSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G542</accession>
    <name>A0A5F8G542_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">KIF23</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. Interacts with ARF6, forming heterodimers and heterotetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Midbody</location>
            <location evidence="3">Midbody ring</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G542"/>
    <dbReference type="Ensembl" id="ENSMODT00000057047.1">
        <property type="protein sequence ID" value="ENSMODP00000042613.1"/>
        <property type="gene ID" value="ENSMODG00000009242.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155837"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009242">
        <property type="expression patterns" value="Expressed in hindlimb bud and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090543">
        <property type="term" value="C:Flemming body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01368">
        <property type="entry name" value="KISc_KIF23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4330:FF:000001">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4330">
        <property type="entry name" value="Kinesin-like protein Kif23, Arf6-interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032384">
        <property type="entry name" value="Kif23_Arf-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038105">
        <property type="entry name" value="Kif23_Arf-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF600">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16540">
        <property type="entry name" value="MKLP1_Arf_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 21" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14 20 21" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Kinesin motor" evidence="24">
        <location>
            <begin position="25"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="875"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="914"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="527"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="935" mass="107114" checksum="40C2930EDA0A1A64" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G544</accession>
    <name>A0A5F8G544_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FERM domain containing 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FRMD4A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G544"/>
    <dbReference type="Ensembl" id="ENSMODT00000086784.1">
        <property type="protein sequence ID" value="ENSMODP00000042565.1"/>
        <property type="gene ID" value="ENSMODG00000016916.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230354"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016916">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13191">
        <property type="entry name" value="FERM_C_FRMD4A_FRMD4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17200">
        <property type="entry name" value="FERM_F1_FRMD4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000008">
        <property type="entry name" value="FERM domain containing 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000019">
        <property type="entry name" value="FERM domain containing 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000022">
        <property type="entry name" value="Putative FERM domain-containing protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021774">
        <property type="entry name" value="CUPID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047176">
        <property type="entry name" value="FRMD4A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041785">
        <property type="entry name" value="FRMD4A/B_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079:SF3">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11819">
        <property type="entry name" value="CUPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="58"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="591"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="735"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="950"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="994"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="646"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1053" mass="118686" checksum="AA850850C1833DF7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G545</accession>
    <name>A0A5F8G545_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DYNC1LI1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G545"/>
    <dbReference type="Ensembl" id="ENSMODT00000081205.1">
        <property type="protein sequence ID" value="ENSMODP00000042618.1"/>
        <property type="gene ID" value="ENSMODG00000015210.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008295"/>
    <dbReference type="OMA" id="RCNIWIL"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015210">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF2">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="375"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="447"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="484" mass="52456" checksum="D24B1BAE240C157B" modified="2019-12-11" version="1">MAAVGRAGSFSSSPPALTAANGFAPATCTGNGDKAEEDDGQNLWSCILSEVSTRSRSKLPSGKNVLLLGEDGAGKTSLIGRIQGRPEECKKGRGAEYLYLSVHDEDRDDQTRCNVWILDGDLYHKGLLKFAMEANSLRDTLVILVVDMSKPWTALDSLQKWASVVREHIDKLKIPPEEMKEMEQKLIRDFQEYVEPGEDFPASPQRRSTLQEDKDDSVMLPLGADTLTYNLGVPVLVVCTKCDAISVLEKEHDYKDEHFDFIQSHIRKFCLQYGAALIYTSVKENKNIDLVYKYIVQKLYGFPFKIPAVVVEKDAVFIPAGWDNDKKIGILHENFQTLKAEDSFEDIITKPPVRKFVHEKEIVAEDDQVFLMKQQSQLAKQPPTAAGRPVDSSPRVPGGSPRTPNRAVSSNVASVSPIPAGSKKIDPNMKAGATSEGVLANFFNSLLSKKTGSPGGPGVGSSSPGGGGGSGGGGSLPSSAKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G548</accession>
    <name>A0A5F8G548_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">B-cell receptor-associated protein</fullName>
            <shortName evidence="12">BCR-associated protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BCAP31</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the export of secreted proteins in the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G548"/>
    <dbReference type="Ensembl" id="ENSMODT00000076590.1">
        <property type="protein sequence ID" value="ENSMODP00000042559.1"/>
        <property type="gene ID" value="ENSMODG00000008300.4"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:107650310"/>
    <dbReference type="GeneTree" id="ENSGT00390000011863"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008300">
        <property type="expression patterns" value="Expressed in placenta and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000011">
        <property type="entry name" value="B-cell receptor-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF15">
        <property type="entry name" value="B-CELL RECEPTOR-ASSOCIATED PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="14">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="15">
        <location>
            <begin position="184"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="133"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="250" mass="28545" checksum="D3F259DA0FC6B3F4" modified="2019-12-11" version="1">MSLQWTAVATFLYAEVFAVLLLCIPFISPKRWQKIFKSRLVQLVVSYGNTFFVVLIVILVLLLIDAVREIRKYDDVTEKVNLQNNPGAMEHFHMKLFRAQRNLHIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAEGASEAAKKYIEENDKLKKGAGTGVGKLDLKDEVLAENKNLKAELKKLTQELAVNKRSLEKAENEALAMRKQSDGLTKEYDRLLEEHARLQVCEWEWDGHRAFCPHPLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G549</accession>
    <name>A0A5F8G549_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rap guanine nucleotide exchange factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cyclic nucleotide ras GEF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Neural RAP guanine nucleotide exchange protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">PDZ domain-containing guanine nucleotide exchange factor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">RA-GEF-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Ras/Rap1-associating GEF-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">RAPGEF2</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAPGEF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007496230.1">
        <property type="nucleotide sequence ID" value="XM_007496168.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000073999.1">
        <property type="protein sequence ID" value="ENSMODP00000042570.1"/>
        <property type="gene ID" value="ENSMODG00000002092.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100023159"/>
    <dbReference type="CTD" id="9693"/>
    <dbReference type="GeneTree" id="ENSGT00940000156418"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002092">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06755">
        <property type="entry name" value="PDZ_RapGEF2_RapGEF6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01785">
        <property type="entry name" value="RA_PDZ-GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000008">
        <property type="entry name" value="Rap guanine nucleotide exchange factor (GEF) 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000001">
        <property type="entry name" value="Rap guanine nucleotide exchange factor (GEF) 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000024">
        <property type="entry name" value="rap guanine nucleotide exchange factor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.870.10:FF:000001">
        <property type="entry name" value="rap guanine nucleotide exchange factor 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45161">
        <property type="entry name" value="CYTOSKELETON-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45161:SF2">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="12 24" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="27">
        <location>
            <begin position="135"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="30">
        <location>
            <begin position="267"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="28">
        <location>
            <begin position="385"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="29">
        <location>
            <begin position="606"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="26">
        <location>
            <begin position="717"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1002"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1096"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1225"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1301"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="1037"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1109"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1142"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1248"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1308"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1356"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1449"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="1490"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00032021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1501" mass="167293" checksum="A2EFE8C0628E863F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G550</accession>
    <name>A0A5F8G550_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-crystallin B2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Beta-B2 crystallin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Beta-crystallin Bp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CRYBB2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G550"/>
    <dbReference type="Ensembl" id="ENSMODT00000057178.1">
        <property type="protein sequence ID" value="ENSMODP00000042582.1"/>
        <property type="gene ID" value="ENSMODG00000010462.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160048"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010462">
        <property type="expression patterns" value="Expressed in ovary and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000005">
        <property type="entry name" value="Crystallin, beta B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF11">
        <property type="entry name" value="BETA-CRYSTALLIN B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="10">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="10">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="10">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="197" mass="22898" checksum="68D2F345EB48C275" modified="2019-12-11" version="1">DGVCPWQAPSVTRGTQYREWNRGGPPAILRSAYPWHPSWDWAGLGVSWQGWVGYEQANCKGEQFVFEKGEYPRWDSWTNSRRTDALSSLRPIKVDSQEHKIILYENPNFTGKKIEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGFQYLFEKGEYKDSSDFGAPHPQVQSVRRIRDMQWHQRGAFHPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G552</accession>
    <name>A0A5F8G552_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Latent-transforming growth factor beta-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Transforming growth factor beta-1-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LTBP1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1. LTBP1 does not bind directly to TGF-beta-1, the active chain of TGFB1. Interacts (via C-terminal domain) with FBN1 (via N-terminal domain). Interacts with FBN2. Interacts with ADAMTSL2. Interacts with EFEMP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LTBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000070653.1">
        <property type="protein sequence ID" value="ENSMODP00000042564.1"/>
        <property type="gene ID" value="ENSMODG00000015435.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155823"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015435">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000198">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000205">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.290.10:FF:000004">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000019">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000046">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 1 isoform x2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.290.10:FF:000012">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000515">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000077">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.290.10:FF:000001">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.290.10:FF:000002">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000056">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000115">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.290.10">
        <property type="entry name" value="TGF-beta binding (TB) domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017878">
        <property type="entry name" value="TB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036773">
        <property type="entry name" value="TB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00683">
        <property type="entry name" value="TB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57581">
        <property type="entry name" value="TB module/8-cys domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51364">
        <property type="entry name" value="TB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0340">Growth factor binding</keyword>
    <keyword evidence="11" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023811517" description="Latent-transforming growth factor beta-binding protein 1" evidence="19">
        <location>
            <begin position="19"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="TB" evidence="21">
        <location>
            <begin position="585"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="654"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="TB" evidence="21">
        <location>
            <begin position="705"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="941"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="983"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="1024"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="1065"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="1106"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="1148"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="TB" evidence="21">
        <location>
            <begin position="1252"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="1372"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="TB" evidence="21">
        <location>
            <begin position="1429"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="1567"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="75"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1622" mass="177599" checksum="42C6483BC698C3D9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G555</accession>
    <name>A0A5F8G555_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Leupaxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LPXN</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the paxillin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G555"/>
    <dbReference type="FunCoup" id="A0A5F8G555">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042575"/>
    <dbReference type="Ensembl" id="ENSMODT00000077714.1">
        <property type="protein sequence ID" value="ENSMODP00000042575.1"/>
        <property type="gene ID" value="ENSMODG00000020172.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160259"/>
    <dbReference type="InParanoid" id="A0A5F8G555"/>
    <dbReference type="OMA" id="YCQPCFT"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020172">
        <property type="expression patterns" value="Expressed in blood and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050859">
        <property type="term" value="P:negative regulation of B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033628">
        <property type="term" value="P:regulation of cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09410">
        <property type="entry name" value="LIM3_Leupaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09339">
        <property type="entry name" value="LIM4_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000008">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000012">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000018">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF23">
        <property type="entry name" value="LEUPAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023829215" evidence="13">
        <location>
            <begin position="28"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="233"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="291"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="351"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="409" mass="45952" checksum="AA2AA1066764A598" modified="2019-12-11" version="1">MRGGVGGRFCLVRRGLVMCYLTSFCSSFLGGPDAVLEELERSSLGESDEDPRPLLQPSNDGKMEAAKACPVQNDTQPVPVQIRYTTKSEDVNIYSTVQEPEPRRLPQATSAAAQLDELMAHLCQMQAKVMEKSDGPKEPLPKKNDSSASLDTMLGGLEQDLQDLGIATVPKGHCASCQKPIVGKMITALGWTWHPEHFVCTHCKKEIGCSSPFFERNGSAYCSQDYHQLFSPRCAYCAAPILDKVLTAMDQTWHPEHFFCSHCGEVFNEEGFLEKDKKPYCRRDFLAMFAPKCRGCNRPVLENYLSAMDAVWHPECFVCGDCFKPFSTASFFELHGQPFCELHYHHRRGTICPGCEQPIRGRCVSAMGRRFHPEHFVCAFCLSQLNKGVFREKNDKAYCQPCFVKLFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G556</accession>
    <name>A0A5F8G556_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 195</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G556"/>
    <dbReference type="Ensembl" id="ENSMODT00000083300.1">
        <property type="protein sequence ID" value="ENSMODP00000042551.1"/>
        <property type="gene ID" value="ENSMODG00000024125.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155965"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000024125">
        <property type="expression patterns" value="Expressed in uterus and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001984">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003102">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000044">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000416">
        <property type="entry name" value="zinc finger protein 879 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000057">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="63"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="728"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="759" mass="88406" checksum="93356EDFCF761823" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G557</accession>
    <name>A0A5F8G557_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">VARS2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the attachment of valine to tRNA(Val) in a two-step reaction: valine is first activated by ATP to form Val-AMP and then transferred to the acceptor end of tRNA(Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G557"/>
    <dbReference type="Ensembl" id="ENSMODT00000062350.1">
        <property type="protein sequence ID" value="ENSMODP00000042628.1"/>
        <property type="gene ID" value="ENSMODG00000015848.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159890"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015848">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000120">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000007">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF71">
        <property type="entry name" value="VALINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="17">
        <location>
            <begin position="113"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="988" mass="111748" checksum="23AB1E858C55542F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G559</accession>
    <name>A0A5F8G559_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Receptor-type tyrosine-protein phosphatase S</fullName>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Receptor-type tyrosine-protein phosphatase sigma</fullName>
        </alternativeName>
    </protein>
    <organism evidence="37 38">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="37" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="37" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Synapse</location>
            <location evidence="26">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="Ensembl" id="ENSMODT00000076522.1">
        <property type="protein sequence ID" value="ENSMODP00000042592.1"/>
        <property type="gene ID" value="ENSMODG00000045528.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153617"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000045528">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd05738">
        <property type="entry name" value="IgI_2_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05739">
        <property type="entry name" value="IgI_3_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000549">
        <property type="entry name" value="Protein tyrosine phosphatase, receptor type S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000027">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000036">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000066">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000068">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000144">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000015">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000082">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0966">Cell projection</keyword>
    <keyword evidence="25" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="22" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="24" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="19 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-0675">Receptor</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0770">Synapse</keyword>
    <keyword evidence="9" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="11 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 32" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="1176"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="35">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="35">
        <location>
            <begin position="110"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="35">
        <location>
            <begin position="207"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="296"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="391"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="489"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="583"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="673"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="773"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="871"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="36">
        <location>
            <begin position="971"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="33">
        <location>
            <begin position="1256"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="34">
        <location>
            <begin position="1260"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00073611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00079496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1327" mass="146958" checksum="973D41B7DD0485FB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVU3</accession>
    <name>A0A5F8GVU3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dystrophin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DMD</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007493428.1">
        <property type="nucleotide sequence ID" value="XM_007493366.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVU3"/>
    <dbReference type="Ensembl" id="ENSMODT00000082085.1">
        <property type="protein sequence ID" value="ENSMODP00000051773.1"/>
        <property type="gene ID" value="ENSMODG00000021126.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100029652"/>
    <dbReference type="CTD" id="1756"/>
    <dbReference type="GeneTree" id="ENSGT00940000154342"/>
    <dbReference type="OrthoDB" id="10057795at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021126">
        <property type="expression patterns" value="Expressed in uterine wall and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16246">
        <property type="entry name" value="EFh_DMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000008">
        <property type="entry name" value="Dystrophin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000001">
        <property type="entry name" value="Dystrophin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000023">
        <property type="entry name" value="dystrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF25">
        <property type="entry name" value="DYSTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="11">
        <location>
            <begin position="240"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="618" mass="70512" checksum="F905D319848672C2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVU4</accession>
    <name>A0A5F8GVU4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline rich 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PRR14</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007498562.1">
        <property type="nucleotide sequence ID" value="XM_007498500.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVU4"/>
    <dbReference type="Ensembl" id="ENSMODT00000085306.1">
        <property type="protein sequence ID" value="ENSMODP00000051286.1"/>
        <property type="gene ID" value="ENSMODG00000001588.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100018175"/>
    <dbReference type="CTD" id="78994"/>
    <dbReference type="GeneTree" id="ENSGT00520000055626"/>
    <dbReference type="OrthoDB" id="6163216at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001588">
        <property type="expression patterns" value="Expressed in lung and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026320">
        <property type="entry name" value="PRR14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028149">
        <property type="entry name" value="Tantalus-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14522">
        <property type="entry name" value="EMO2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14522:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15386">
        <property type="entry name" value="Tantalus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tantalus-like" evidence="3">
        <location>
            <begin position="532"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="648" mass="70996" checksum="D33EBBCF70BA1ACF" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVV1</accession>
    <name>A0A5F8GVV1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterogeneous nuclear ribonucleoproteins A2/B1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HNRNPA2B1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVV1"/>
    <dbReference type="Ensembl" id="ENSMODT00000054016.1">
        <property type="protein sequence ID" value="ENSMODP00000051675.1"/>
        <property type="gene ID" value="ENSMODG00000000603.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154431"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000603">
        <property type="expression patterns" value="Expressed in hindlimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12762">
        <property type="entry name" value="RRM1_hnRNPA2B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12581">
        <property type="entry name" value="RRM2_hnRNPA2B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000040">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A2/B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000108">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoproteins A2/B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034486">
        <property type="entry name" value="hnRNPA2B1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026:SF13">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS A2_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026">
        <property type="entry name" value="HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="249" mass="28315" checksum="E615BE85C23E2097" modified="2019-12-11" version="1">MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMSARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQEVAILEVVLVMEEEEEDMVVEDLAMATRVGATEVVMTTMEEAITEVGTTMTLETIINNLQTMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVV2</accession>
    <name>A0A5F8GVV2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100021431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVV2"/>
    <dbReference type="Ensembl" id="ENSMODT00000057882.1">
        <property type="protein sequence ID" value="ENSMODP00000051489.1"/>
        <property type="gene ID" value="ENSMODG00000025714.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160031"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025714">
        <property type="expression patterns" value="Expressed in spermatid and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000012">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="88"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="411" mass="46936" checksum="A07B08AA575C5170" modified="2019-12-11" version="1">MDPVIKGRCEIQWLLADACWILLLGTAFGSTNITRVQNPEADMNISQIISYWGYPGEEYDVVTEDGFILGVYRIPHGKGNSNRKAQRPVVYLQHGMFMSASIWIANPPESSLAFALADAGCDVWMGNSRGTVWSRKHTHYSPESPEFWAFSFDEMAKYDLPAILNFIMKKTRREQLYYVGHSQGTTIAFAAFSTNPRLARRINTFFALAPVVSVQYSKGPLKTLISIPTPILKVIFGRKEMFPKSFWNHFFVSQVCNQKGFDHLCADFLFRVSGYDRENLNMSRLDVYLSQNPAGTSVQNVVHWRQILYSAKFQAYDWGNPDENMEHYNQVTPPLYDLEAVKVPIVMWSGGQDRFAAPKEVEKLIPRLSKLIYHRNIPYYNHIDFVLGIDVPTCGQRNLSIGVELMSVTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVV3</accession>
    <name>A0A5F8GVV3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GBE1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVV3"/>
    <dbReference type="Ensembl" id="ENSMODT00000080477.1">
        <property type="protein sequence ID" value="ENSMODP00000051296.1"/>
        <property type="gene ID" value="ENSMODG00000016876.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017040"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016876">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000550">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="201"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="643" mass="74253" checksum="9C7A3EC23C58A892" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVV4</accession>
    <name>A0A5F8GVV4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
            <ecNumber evidence="6">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100030124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="6"/>
    <dbReference type="RefSeq" id="XP_001372551.1">
        <property type="nucleotide sequence ID" value="XM_001372514.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVV4"/>
    <dbReference type="Ensembl" id="ENSMODT00000066828.1">
        <property type="protein sequence ID" value="ENSMODP00000051652.1"/>
        <property type="gene ID" value="ENSMODG00000001899.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100030124"/>
    <dbReference type="KEGG" id="mdo:100030124"/>
    <dbReference type="GeneTree" id="ENSGT00940000154679"/>
    <dbReference type="OMA" id="EEWFGEV"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001899">
        <property type="expression patterns" value="Expressed in spermatid and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03209">
        <property type="entry name" value="GST_C_Mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03075">
        <property type="entry name" value="GST_N_Mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000003">
        <property type="entry name" value="Glutathione S-transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000603">
        <property type="entry name" value="Glutathione S-transferase Mu 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003081">
        <property type="entry name" value="GST_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF133">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE MU 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01267">
        <property type="entry name" value="GSTRNSFRASEM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="90"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="218" mass="25618" checksum="864796C7AA610046" modified="2019-12-11" version="1">MPIVLGYWDIRGLAHAIRLLLEYTGAEYEEKVYRFGDAPDFDRSQWLDVKFNLGLAFPNLPYLIDGDKKITQSNAILRYIARQYNLCGETEEERIRVDMLENHVMDIRMQLARVCYNPNFEVMKIEYLQQLPGQLKLFSLFLGKCSWFAGNKITFVDFLVYDVLDQNRKFEPSCLEKFSNLKEFLHRFESLSSIATYLASERCQPYPIFAKMACWGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVV5</accession>
    <name>A0A5F8GVV5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Copine 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CPNE6</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVV5"/>
    <dbReference type="Ensembl" id="ENSMODT00000068138.1">
        <property type="protein sequence ID" value="ENSMODP00000051783.1"/>
        <property type="gene ID" value="ENSMODG00000003641.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161567"/>
    <dbReference type="OMA" id="YKTNRDQ"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003641">
        <property type="expression patterns" value="Expressed in spinal cord and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000063">
        <property type="entry name" value="Copine 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF5">
        <property type="entry name" value="COPINE-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="118"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="529" mass="58199" checksum="B6B59A161DF720C8" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVV6</accession>
    <name>A0A5F8GVV6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase RNF8</fullName>
            <ecNumber evidence="11">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RING finger protein 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase RNF8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 17" type="primary">RNF8</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Telomere</location>
        </subcellularLocation>
        <text evidence="11">Recruited at uncapped telomeres. Following DNA double-strand breaks, recruited to the sites of damage. During prophase, concomitant with nuclear envelope breakdown, localizes throughout the cell, with a dotted pattern. In telophase, again in the nucleus and also with a discrete dotted pattern in the cytoplasm. In late telophase and during cytokinesis, localizes in the midbody of the tubulin bridge joining the daughter cells. Does not seem to be associated with condensed chromosomes at any time during the cell cycle. During spermatogenesis, sequestered in the cytoplasm by PIWIL1: RNF8 is released following ubiquitination and degradation of PIWIL1.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CHFR family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVV6"/>
    <dbReference type="FunCoup" id="A0A5F8GVV6">
        <property type="interactions" value="1803"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051680"/>
    <dbReference type="Ensembl" id="ENSMODT00000062652.1">
        <property type="protein sequence ID" value="ENSMODP00000051680.1"/>
        <property type="gene ID" value="ENSMODG00000049352.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00400000022349"/>
    <dbReference type="InParanoid" id="A0A5F8GVV6"/>
    <dbReference type="OMA" id="RRKDECP"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000049352">
        <property type="expression patterns" value="Expressed in hindlimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045190">
        <property type="term" value="P:isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905168">
        <property type="term" value="P:positive regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990166">
        <property type="term" value="P:protein localization to site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042770">
        <property type="term" value="P:signal transduction in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035092">
        <property type="term" value="P:sperm DNA condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22663">
        <property type="entry name" value="FHA_RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16535">
        <property type="entry name" value="RING-HC_RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000050">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000015">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000242">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03067">
        <property type="entry name" value="RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017335">
        <property type="entry name" value="RNF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0779">Telomere</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="15">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="398"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for interaction with PIWIL1" evidence="11">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="266"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="497" mass="56919" checksum="DFC370FBCCDEE4F0" modified="2019-12-11" version="1">MGDPGGGGGGRVLCLQRVGMSAEWLLLEDRSEVTVGRGSDVTYQLLSKICPLMISRNHCVFKQNAEGQWTMMDNKSLNGVWLNKERLDPLKAYPIKEGDRIQLGVPLENKENAEYEYEVIEEDWEKIHLCLALRNDRPVVRCSRTKRKCSLEELDSPGAEGSSDSRSKVIKVSHDHEQSGKSCGRAEMAKQTAKNMDRKLAFPGPSGERTTEDDLPVSEKATVLWNKKHKGPSLSQSQNSLDMLKKTMARILKLKVKVQEKQVAVLSVKQQSHKGAQKEIVKMEEELQELQDQLFTEQVQQQQRVEQLEKNFQEKEQHLEGLEKQHGEKDLKEQLAQALQEHHILMEELSRSKKDFEAIIQAKNKELEQTKEEKEKVKAQKEEVLNQMNDVLENELQCIICSEHFIEAVTLNCAHSFCSYCIDEWMKRKVECPICRQDIESKTRSLVLDNCINKMVEKLSSEMKERREILINERRGGSLSSSGSRCDLAQMETQVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVV7</accession>
    <name>A0A5F8GVV7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deuterosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coiled-coil domain-containing protein 67</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DEUP1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEP63 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVV7"/>
    <dbReference type="Ensembl" id="ENSMODT00000076758.1">
        <property type="protein sequence ID" value="ENSMODP00000051494.1"/>
        <property type="gene ID" value="ENSMODG00000000922.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153190"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000922">
        <property type="expression patterns" value="Expressed in spermatocyte and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057656">
        <property type="entry name" value="CEP63/Deup1_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031470">
        <property type="entry name" value="CEP63/Deup1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18875:SF5">
        <property type="entry name" value="DEUTEROSOME ASSEMBLY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18875">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-24/CYTOSKELETAL PROTEIN SOJO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25771">
        <property type="entry name" value="CC_CEP152-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17045">
        <property type="entry name" value="CEP63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CEP63/Deup1 N-terminal" evidence="9">
        <location>
            <begin position="60"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="CEP63/Deup1 CEP152 binding coiled coil" evidence="10">
        <location>
            <begin position="614"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="134"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="272"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="657" mass="76907" checksum="114A56A4317F93C1" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVV8</accession>
    <name>A0A5F8GVV8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Regulating synaptic membrane exocytosis 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RIMS2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000070866.1">
        <property type="protein sequence ID" value="ENSMODP00000051657.1"/>
        <property type="gene ID" value="ENSMODG00000005498.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155236"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005498">
        <property type="expression patterns" value="Expressed in cerebellum and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04031">
        <property type="entry name" value="C2A_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04028">
        <property type="entry name" value="C2B_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06714">
        <property type="entry name" value="PDZ_RIM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000001">
        <property type="entry name" value="Regulating synaptic membrane exocytosis 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000003">
        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000003">
        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000044">
        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054386">
        <property type="entry name" value="RIM_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF15">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22601">
        <property type="entry name" value="RIM2a_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RabBD" evidence="15">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="634"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="787"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1539"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="728"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="920"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="976"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1073"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1231"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1405"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1443"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="976"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1073"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1166"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1231"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1254"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1299"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1321"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1448"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1693" mass="192344" checksum="3D1D90BFA45D4B2E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVV9</accession>
    <name>A0A5F8GVV9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VPS41 subunit of HOPS complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">VPS41</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVV9"/>
    <dbReference type="Ensembl" id="ENSMODT00000053322.1">
        <property type="protein sequence ID" value="ENSMODP00000051788.1"/>
        <property type="gene ID" value="ENSMODG00000012622.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000481"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012622">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000107">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="2">
        <location>
            <begin position="28"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="741" mass="84228" checksum="E92E72BA91C6D787" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVW1</accession>
    <name>A0A5F8GVW1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oxytocin-neurophysin 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">OXT</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM). Interacts with oxytocin receptor (OXTR) (Ki=110 nM).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vasopressin/oxytocin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVW1"/>
    <dbReference type="Ensembl" id="ENSMODT00000080068.1">
        <property type="protein sequence ID" value="ENSMODP00000050763.1"/>
        <property type="gene ID" value="ENSMODG00000005441.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000086682.1">
        <property type="protein sequence ID" value="ENSMODP00000051685.1"/>
        <property type="gene ID" value="ENSMODG00000005441.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004511"/>
    <dbReference type="OMA" id="ACVINDP"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005441">
        <property type="expression patterns" value="Expressed in testis and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005185">
        <property type="term" value="F:neurohypophyseal hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042310">
        <property type="term" value="P:vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.9.10:FF:000001">
        <property type="entry name" value="oxytocin-neurophysin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.9.10">
        <property type="entry name" value="Neurohypophysial hormone domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000981">
        <property type="entry name" value="Neurhyp_horm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036387">
        <property type="entry name" value="Neurhyp_horm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022423">
        <property type="entry name" value="Neurohypophysial_hormone_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681">
        <property type="entry name" value="NEUROPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681:SF9">
        <property type="entry name" value="VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00220">
        <property type="entry name" value="Hormone_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00184">
        <property type="entry name" value="Hormone_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001815">
        <property type="entry name" value="Nonapeptide_hormone_precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00831">
        <property type="entry name" value="NEUROPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00003">
        <property type="entry name" value="NH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49606">
        <property type="entry name" value="Neurophysin II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00264">
        <property type="entry name" value="NEUROHYPOPHYS_HORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0838">Vasoactive</keyword>
    <keyword evidence="7" id="KW-0839">Vasoconstrictor</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044621514" evidence="10">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="33"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="72"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001815-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="136" mass="13933" checksum="28101A7BCF302521" modified="2019-12-11" version="1">MGNPGSRPGLAPRTRPGFACCYLLALLALASACYIQNCPIGGKRSALDMDVRKCLPCGPGSKGRCFGPSICCGEELGCYVGTAETLRCQEESYLPSPCQSGQKPCGSGGRCAASGICCSSDGCGLDPACDQESTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVW2</accession>
    <name>A0A5F8GVW2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centromere protein L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CENPL</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-L/IML3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVW2"/>
    <dbReference type="Ensembl" id="ENSMODT00000084879.1">
        <property type="protein sequence ID" value="ENSMODP00000051499.1"/>
        <property type="gene ID" value="ENSMODG00000004148.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013877"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004148">
        <property type="expression patterns" value="Expressed in forelimb bud and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="330" mass="37655" checksum="1AA9E982F9EA783E" modified="2019-12-11" version="1">MDSLDVPEFTPKHRVPPRLRDYFTGASPFHRHLESVRKQTSFGQTPFRRKIPECSPLQENFDPQRIAFLLHKQWTLYTLTPMYKFSYTNLKEYSSLLKSFIAAEKQKGLAVEMEEDFNFKVIFSTLSGVKGTQRDPAAFLVQIISKSQLSSKNAEEKVVWTGWFCCVYGDSLLENVPDDFTCLPLFLANGAESNTALIGTWFQQTFDCRFTRLTISAFNLSWMAAMWTACNLEHYVAATELLWSVPCSPQSLDISYAIHPEDAKALWDSVHQAPEEITQEEVDLFIDCLCSHFHRHFKINLAATRLVCVSTSVASAHTDGKIKVVKEMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVW3</accession>
    <name>A0A5F8GVW3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dehydrogenase/reductase SDR family member 7B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Short-chain dehydrogenase/reductase family 32C member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DHRS7B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007498528.1">
        <property type="nucleotide sequence ID" value="XM_007498466.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVW3"/>
    <dbReference type="FunCoup" id="A0A5F8GVW3">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051793"/>
    <dbReference type="Ensembl" id="ENSMODT00000075299.1">
        <property type="protein sequence ID" value="ENSMODP00000051793.1"/>
        <property type="gene ID" value="ENSMODG00000001421.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100017149"/>
    <dbReference type="KEGG" id="mdo:100017149"/>
    <dbReference type="CTD" id="25979"/>
    <dbReference type="GeneTree" id="ENSGT00940000158171"/>
    <dbReference type="InParanoid" id="A0A5F8GVW3"/>
    <dbReference type="OMA" id="YFWIMAK"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001421">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05332">
        <property type="entry name" value="11beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000122">
        <property type="entry name" value="Dehydrogenase/reductase SDR family member 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004825">
        <property type="entry name" value="PRK06181.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="323" mass="35552" checksum="F9FD576DE8404311" modified="2019-12-11" version="1">MVSLATRRIVLKGKLMDYITSIAIIPLLVGCMGIFGLFRFLQWIRMKAYIQDSVVVITGATSGLGKECAKVFYTAGAKLILCGRNNERLEELIRELIATNIKKTHRPHAVVFDLAESKTIVPAANEILKYSGHVDILINNAGVSYRGTIMDTALEVDKKVMETNYFGPVALTKAILPSMIEKKQGHIVVISSIQGKISVPFRSAYAASKHATQAFFDCLRAEVEQHDIEVTVISPGYIQTNLSLNALTADGSTYGVMDKNTANGRSPTEVAYAVLTAVGKKKKEVMVADLLPCLAVSLRTLFPRLFFYIMAMRARKERKGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVW7</accession>
    <name>A0A5F8GVW7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tubulin polymerization promoting protein family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TPPP2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPPP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVW7"/>
    <dbReference type="Ensembl" id="ENSMODT00000062869.1">
        <property type="protein sequence ID" value="ENSMODP00000051504.1"/>
        <property type="gene ID" value="ENSMODG00000046208.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153875"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000046208">
        <property type="expression patterns" value="Expressed in spermatid and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000057">
        <property type="entry name" value="Tubulin polymerization-promoting protein family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932">
        <property type="entry name" value="P25 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932:SF21">
        <property type="entry name" value="TUBULIN POLYMERIZATION-PROMOTING PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="163" mass="18055" checksum="0AFEB652929CBCBE" modified="2019-12-11" version="1">MASEAEKTFHHFAAYGESSSSGNEIHNKNFSKMCKDCGIMDGKIITSTDVDIVFSKVKKKNARSINWTECQMALKEMGQKKFKDKSPEEALQSMFALMVNKVPVASGVTKTVAVGGVDRLTDTSKYTGSTLHLKQKIPPLLKETVKRAWLLMRGSYASFSHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVW8</accession>
    <name>A0A5F8GVW8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA transcription, translation and transport factor protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RTRAF</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTRAF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVW8"/>
    <dbReference type="FunCoup" id="A0A5F8GVW8">
        <property type="interactions" value="2381"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051667"/>
    <dbReference type="Ensembl" id="ENSMODT00000080587.1">
        <property type="protein sequence ID" value="ENSMODP00000051667.1"/>
        <property type="gene ID" value="ENSMODG00000013211.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005163"/>
    <dbReference type="InParanoid" id="A0A5F8GVW8"/>
    <dbReference type="OMA" id="YPMRILR"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013211">
        <property type="expression patterns" value="Expressed in blood and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019265">
        <property type="entry name" value="RTRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15924">
        <property type="entry name" value="CLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10036">
        <property type="entry name" value="RLL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="297" mass="33722" checksum="ADA44C6505C2A1AD" modified="2019-12-11" version="1">KTSLLFLISPSGLIVKEISSSTSGSSETVVKLHGQSTDSLPQATYRKPKTSSDRHSLSLDDIRLYQKDFLQIADETEFRNFIVWLEDQKIRHYKIEDRGNLRNIHNSEWPKFFEKYLKDVNCPFKIQERQETIDWLLGLAVRLEYGDNADKYKDSTPDNAKNADNAAKNVEPLINLDVNNPDFKAGVMALANLLQIQRHDDYLVMLKAIRILVQERLTQEAVAKANQTKEGLPVALDKHILGFDTGDAVLNEAAQILRLLHIEELRELQTKINEAIVAVQAIIADPKTDHRLGKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVW9</accession>
    <name>A0A5F8GVW9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium channel tetramerization domain containing 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KCTD20</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVW9"/>
    <dbReference type="Ensembl" id="ENSMODT00000057661.1">
        <property type="protein sequence ID" value="ENSMODP00000051311.1"/>
        <property type="gene ID" value="ENSMODG00000013553.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007975"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013553">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039886">
        <property type="entry name" value="BTBD10/KCTD20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="252" mass="29016" checksum="1154796468B943D9" modified="2019-12-11" version="1">MNIHRASEGDRSIRQESSFLVENIPGSSQEKEENCLTSCLQNPNLPVCSRNDGALLHELSNDGAHKQFDHYLEELILPIMVGSAKKGERECHIVVLTDEDSVDWDEDHPPPMGEEYSQILYSSKLYRFFKYIENRDVAKTVLKERGLKNIRIGIEGYPTCKEKIKRRPGGRSEVIYNYVQRPFIQMSWEKEEGKSRHVDFQCVRSKSLTNLVTAEEDVSEDQENLMHHPPQVDELDRLNAPLSQMAPNDFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW61</accession>
    <name>A0A5F8GW61_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Centrin-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100016035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW61"/>
    <dbReference type="Ensembl" id="ENSMODT00000079594.1">
        <property type="protein sequence ID" value="ENSMODP00000051898.1"/>
        <property type="gene ID" value="ENSMODG00000018901.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162309"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018901">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000070">
        <property type="entry name" value="Centrin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="155" mass="17503" checksum="B6A69A0D03AC0B19" modified="2019-12-11" version="1">MASNYRPSTGLRKKPNVKVELTEGQKQEIKEAFDLFDVDGSGSIDVKELKIAMRALGFEPKKEEIKKMIAEIDKEGFGTINFEDFFAMMSVKMSEKDEKEEILKAFKLFDDDCTGGITLKNIKRVAKELGENLSDDELQKAICEMFPSTLLGRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW62</accession>
    <name>A0A5F8GW62_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase RBX1</fullName>
            <ecNumber evidence="13">2.3.2.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">E3 ubiquitin-protein transferase RBX1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">RING finger protein 75</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RING-box protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RBX1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.32"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.32" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW62"/>
    <dbReference type="Ensembl" id="ENSMODT00000058010.1">
        <property type="protein sequence ID" value="ENSMODP00000051737.1"/>
        <property type="gene ID" value="ENSMODG00000013054.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000168153"/>
    <dbReference type="OMA" id="NACPLDN"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013054">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061663">
        <property type="term" value="F:NEDD8 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="105" mass="11917" checksum="7F66096C0E6C6A8F" modified="2019-12-11" version="1">MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW63</accession>
    <name>A0A5F8GW63_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acidic leucine-rich nuclear phosphoprotein 32 family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ANP32B</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Multifunctional protein that is involved in the regulation of many processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the ANP32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW63"/>
    <dbReference type="Ensembl" id="ENSMODT00000064236.1">
        <property type="protein sequence ID" value="ENSMODP00000051800.1"/>
        <property type="gene ID" value="ENSMODG00000003261.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182907"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003261">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000003">
        <property type="entry name" value="Acidic leucine-rich nuclear phosphoprotein 32 family member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF2">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="138"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="242" mass="27510" checksum="E2D7DCD11B36ACCA" modified="2019-12-11" version="1">LLQEASQVKELVLDNCRSNDGKIEGLTAEFVNLEFLSLISVGLSTVSNLPELPKLKKLELSDNRIFGGLDVLAEKLPNLTHLNLSGNNLKDISTLEPLKKLEYLKSLDLFNCEVTNLNDYRESVFTLLPQLTYLDGYDQEDKEAPDSDAEVDGVDDEEEEDEEDEDEEDEFDEEDDDEEDDVEGDDYEYDVSGEEEEFGHDGEVDDDEEDEDEDDEDEEDEETGKGEKRKRETDDEGEGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW70</accession>
    <name>A0A5F8GW70_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family with sequence similarity 168 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM168A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM168 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007491070.1">
        <property type="nucleotide sequence ID" value="XM_007491008.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056650981.1">
        <property type="nucleotide sequence ID" value="XM_056795003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW70"/>
    <dbReference type="Ensembl" id="ENSMODT00000073651.1">
        <property type="protein sequence ID" value="ENSMODP00000051752.1"/>
        <property type="gene ID" value="ENSMODG00000007608.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100012024"/>
    <dbReference type="KEGG" id="mdo:100012024"/>
    <dbReference type="CTD" id="23201"/>
    <dbReference type="GeneTree" id="ENSGT00390000005140"/>
    <dbReference type="OrthoDB" id="9940490at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007608">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029247">
        <property type="entry name" value="FAM168A/MANI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31844">
        <property type="entry name" value="MYELIN-ASSOCIATED NEURITE-OUTGROWTH INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14944">
        <property type="entry name" value="TCRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="253" mass="27161" checksum="AFC3506795F14550" modified="2019-12-11" version="1">MVKGLQSSTMNPVYSPVQPGAPYGNPKTMAYTGYPTGYPTAAPTYNPSLYPTNSPSYAPEFQFLHSAYATLLMKQAWPQTSSSCATEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNNAPPPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAIYPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSVPTYRAQGTPTYSYVPPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW71</accession>
    <name>A0A5F8GW71_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein axonemal light chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DNAL1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW71"/>
    <dbReference type="Ensembl" id="ENSMODT00000069710.1">
        <property type="protein sequence ID" value="ENSMODP00000051815.1"/>
        <property type="gene ID" value="ENSMODG00000006662.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01010000222336"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006662">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NXF1/2/3/5-like leucine-rich repeat" evidence="1">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="77" mass="8890" checksum="C4C8FC8EC9EAB0A4" modified="2019-12-11" version="1">MKRLKILYMSNNLVKDWAEFVKLAELLCLEELVFVGNPLEEKSSSEGNWIDEATKRVPKLKKLDGIPVIKQEEEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW72</accession>
    <name>A0A5F8GW72_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="5">dUTPase</shortName>
            <ecNumber evidence="5">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DUT</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW72"/>
    <dbReference type="Ensembl" id="ENSMODT00000066762.1">
        <property type="protein sequence ID" value="ENSMODP00000051913.1"/>
        <property type="gene ID" value="ENSMODG00000002687.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018390"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002687">
        <property type="expression patterns" value="Expressed in hindlimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000019">
        <property type="entry name" value="Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="7">
        <location>
            <begin position="63"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="168" mass="18322" checksum="304F47C9B9A6F1FE" modified="2019-12-11" version="1">MLLRGLNQLFHRLFSYSRPGCSDAIMPCSEANPVAASPSKRSRPAQQEEGTPVRLRFARLSEHATAPSKGSARAAGYDLYSAYDYTIPAMEKALVKTDIQISLPPGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKETFEGKLIIQLIIIAKLVVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW74</accession>
    <name>A0A5F8GW74_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Neural cell adhesion molecule L1-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Close homolog of L1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">CHL1</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">May interact with L1CAM. May interact with ITGB1/ITGA1 heterodimer and ITGB1/ITGA2 heterodimer as well as with ANK3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007500166.1">
        <property type="nucleotide sequence ID" value="XM_007500104.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056660418.1">
        <property type="nucleotide sequence ID" value="XM_056804440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW74"/>
    <dbReference type="Ensembl" id="ENSMODT00000060515.1">
        <property type="protein sequence ID" value="ENSMODP00000051820.1"/>
        <property type="gene ID" value="ENSMODG00000004153.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021727"/>
    <dbReference type="CTD" id="10752"/>
    <dbReference type="GeneTree" id="ENSGT00940000160080"/>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004153">
        <property type="expression patterns" value="Expressed in spinal cord and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd04978">
        <property type="entry name" value="Ig4_L1-NrCAM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05845">
        <property type="entry name" value="IgI_2_L1-CAM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000273">
        <property type="entry name" value="contactin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000057">
        <property type="entry name" value="neural cell adhesion molecule L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000063">
        <property type="entry name" value="neural cell adhesion molecule L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000367">
        <property type="entry name" value="Neural cell adhesion molecule L1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000418">
        <property type="entry name" value="Neural cell adhesion molecule L1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000768">
        <property type="entry name" value="Neural cell adhesion molecule L1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000535">
        <property type="entry name" value="neural cell adhesion molecule L1-like protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000038">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026966">
        <property type="entry name" value="Neurofascin/L1/NrCAM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF45">
        <property type="entry name" value="NEURAL CELL ADHESION MOLECULE L1-LIKE PROTEIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13882">
        <property type="entry name" value="Bravo_FIGEY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="16 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 25" id="KW-0732">Signal</keyword>
    <keyword evidence="9 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023912228" description="Neural cell adhesion molecule L1-like protein" evidence="25">
        <location>
            <begin position="25"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1085"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="35"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="129"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="236"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="332"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="425"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="517"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="616"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="716"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="814"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="917"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1117"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1189"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1117"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00062194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00072847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1211" mass="135596" checksum="3925676E3143108B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW76</accession>
    <name>A0A5F8GW76_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytohesin 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CYTH4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW76"/>
    <dbReference type="Ensembl" id="ENSMODT00000054215.1">
        <property type="protein sequence ID" value="ENSMODP00000051762.1"/>
        <property type="gene ID" value="ENSMODG00000000621.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160865"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000621">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000003">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF323">
        <property type="entry name" value="CYTOHESIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="54"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="250" mass="28640" checksum="1F11A24914F9B581" modified="2019-12-11" version="1">MNLCHPDPADLNQNEAEEFQNIKWHRKQLLEDIQKLKDEIAEVFAQIECFENAEESRLVQKEKELCIGRKKFNMDPSKGIQYLNDHKLLSSSVEEIAQFLYKGEGLNKTAIGDYLGGRDPLNLKILQAFVDLHEFANLHLVQALRQFLWSFRLPGEAQKIDRMMEAFAARYCLCNPGVFQSTDTCYVLSFSVIMLNTSLHNPNVRDKPPFERFVSMNRGINNGGDLPEELLKVLTSSKTNSLVFGKRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW80</accession>
    <name>A0A5F8GW80_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine protease 48-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC103106146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW80"/>
    <dbReference type="Ensembl" id="ENSMODT00000061547.1">
        <property type="protein sequence ID" value="ENSMODP00000051767.1"/>
        <property type="gene ID" value="ENSMODG00000028700.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162519"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000028700">
        <property type="expression patterns" value="Expressed in testis and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000060">
        <property type="entry name" value="Acrosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000182">
        <property type="entry name" value="Zgc:163079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF176">
        <property type="entry name" value="CORIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="30"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="331" mass="37999" checksum="A10C9ABD49F4548A" modified="2019-12-11" version="1">MLRFPGKTTQRFIFPCLPPPEIDGINMEEVCGRPHQSGRALKDVDPSLLRWPWQAKLIYKKRHWCEATLISPSWILTAAHCFRNQTKNPWLWKVHLGSKKIRLDQPNVNQFYDRHVSEIILYPHYNRNPSKDIALAKMSSPVSFMHTIQPICLPTSLEEFQNVTSCWLTGWGREQEAQMRMNLKKHSHVQELEVPLIDQKTCDIYYHKGLNISGQVSLVFDDMFCAGFSSDKNICQSGFGGSLSCKINGTWRQAGIVSWEMNCDLPSLPSVYTNISIYTPWILKTTNSSTPDLHPSGIFCTFPLLLLWDFLGPLSSLFTFILIKFITFIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW81</accession>
    <name>A0A5F8GW81_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor AP-2 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TFAP2B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW81"/>
    <dbReference type="Ensembl" id="ENSMODT00000057136.1">
        <property type="protein sequence ID" value="ENSMODP00000051830.1"/>
        <property type="gene ID" value="ENSMODG00000018831.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182848"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018831">
        <property type="expression patterns" value="Expressed in hindlimb bud and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008122">
        <property type="entry name" value="TF_AP2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF14">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01750">
        <property type="entry name" value="AP2BTNSCPFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="212"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="442" mass="48312" checksum="DC1142CD18AA6EC7" modified="2019-12-11" version="1">MLVHTYSDMDRHDGVPSHSSRLSQLGSVSQGPYSSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLHQPQQHPWGQRQRQEVGSEAGSLLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDSGMGDSLSLHGIGHPGMEDVQSVEDANNSGMNLLDQSVIKKVPVPPKSVTSLMMNKDGFLGGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHTDLSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNSTTNRHTSGEGPGSKTGDKEEKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW82</accession>
    <name>A0A5F8GW82_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MAM and LDL receptor class A domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MALRD1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000060584.1">
        <property type="protein sequence ID" value="ENSMODP00000051928.1"/>
        <property type="gene ID" value="ENSMODG00000009440.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158809"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009440">
        <property type="expression patterns" value="Expressed in kidney and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000142">
        <property type="entry name" value="MAM and LDL receptor class A domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000182">
        <property type="entry name" value="MAM and LDL-receptor class A domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000186">
        <property type="entry name" value="MAM and LDL-receptor class A domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000067">
        <property type="entry name" value="Serine peptidase inhibitor, Kunitz type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF140">
        <property type="entry name" value="MAM AND LDL-RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MAM" evidence="7">
        <location>
            <begin position="51"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="7">
        <location>
            <begin position="266"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="7">
        <location>
            <begin position="468"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="7">
        <location>
            <begin position="691"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="7">
        <location>
            <begin position="902"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="7">
        <location>
            <begin position="1127"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="7">
        <location>
            <begin position="1344"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="7">
        <location>
            <begin position="1558"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="7">
        <location>
            <begin position="1767"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="883"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1109"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1303"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1310"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1522"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1529"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1541"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1732"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1744"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1963"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1987"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1994"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2006"/>
            <end position="2021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2118" mass="236796" checksum="FEE47C1CB7E23D7B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW84</accession>
    <name>A0A5F8GW84_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Leucine rich repeats and transmembrane domains 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LRTM2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLITRK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW84"/>
    <dbReference type="Ensembl" id="ENSMODT00000079441.1">
        <property type="protein sequence ID" value="ENSMODP00000051772.1"/>
        <property type="gene ID" value="ENSMODG00000018421.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157572"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018421">
        <property type="expression patterns" value="Expressed in cerebellum and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000015">
        <property type="entry name" value="Leucine rich repeat containing 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773:SF10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="17">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="18">
        <location>
            <begin position="186"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="357" mass="39515" checksum="629A0B98D10EDF2B" modified="2019-12-11" version="1">GCSAGRHFPGGIACWISLYAAETLPTCPFSCKCDSRSLEVDCSGLGLSSVPPDVPAATRTLLLLNNKLNVLPSWVFSNLSSLQRLDLSNNFLDQLPQAIFGDLANLTELQLRNNSIRTLDRDLLQHAPLLRHLDLSINGLAQLPPGFFDGLLALRSLSLRSNRLQNLDRVTFEPLVSLQLLQVGDNPWECDCNLRDFKHWMEWFSYRGGRLDQLACTMPKELRGKDMRMVPMEMFNYCSQLEESSSAGLEVSGPPCTKASLEPVKPKPGAEPEPEPSTACPQKQRYRPVSVRRAIGTVIIAGVVCGIVCIMMVVAAAYGCIYASLMAKYHRELKKRQPLMGDPEGEHEEQKQISSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW86</accession>
    <name>A0A5F8GW86_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carcinoembryonic antigen-related cell adhesion molecule 5-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW86"/>
    <dbReference type="Ensembl" id="ENSMODT00000083679.1">
        <property type="protein sequence ID" value="ENSMODP00000051835.1"/>
        <property type="gene ID" value="ENSMODG00000049711.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000049711">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="73"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="160"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="275" mass="30605" checksum="1249FE98E30A4E3B" modified="2019-12-11" version="1">MTCNAMGQIHAYRWFINGLAPVGSRIQLSPDKRILTLRRLTRRENKGPYVCEIENPLFRNRSDPFPLNVTYGPDIATIVRSAGVYPTGVNITLSCVADSNPPAQFTWLQNGQSVSNSAIFSVISSLNHAGTYTCIASNSFTGLTHTATKNIIIYAPLSKPTIITSNNTAVETKDFSMTCNATGQIHAYRWFINGLAPGGNRIQLSPDKRTLTIRSLRRMENKGPYVCEIENLLFRERSNPFTLNVTCEYIASSYMVPSYSLVVCSQRPRLIQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW87</accession>
    <name>A0A5F8GW87_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine aminopeptidase</fullName>
            <ecNumber evidence="7">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">METAP1D</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW87"/>
    <dbReference type="Ensembl" id="ENSMODT00000081782.1">
        <property type="protein sequence ID" value="ENSMODP00000051406.1"/>
        <property type="gene ID" value="ENSMODG00000008888.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157735"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008888">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000011">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M24" evidence="8">
        <location>
            <begin position="100"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="345" mass="38479" checksum="800018DC33BA97C4" modified="2019-12-11" version="1">MAAPRVIHLALNRGHMMGCPRVFCSPVSPVYLHKQTSNQQRRYFFSQRQKRTTHRIVLPAAVSSAHLVPQHIKKPDYVTTGIVPDWGDSIEVKKEDQIQGLRQACQLARHVLLLAGKSLKVDMTTEEIDSLVHQEIIRHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDKYGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISRITRESGLQVCPHFVGHGIGSFFHGHPEIWHHEPIIVEGSPEFKVLEDKWTVVSTDDKRCLIRSFYFFVLFQTPQLTGRMLGGGLSTANLQSQLLIVKCVFQISAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW88</accession>
    <name>A0A5F8GW88_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KIFAP3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW88"/>
    <dbReference type="Ensembl" id="ENSMODT00000065884.1">
        <property type="protein sequence ID" value="ENSMODP00000051933.1"/>
        <property type="gene ID" value="ENSMODG00000003544.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003574"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003544">
        <property type="expression patterns" value="Expressed in spermatid and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008658">
        <property type="entry name" value="KAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605:SF2">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05804">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01297">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="589"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="772" mass="89233" checksum="56867DDBA92CA884" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7U3</accession>
    <name>A0A5F8H7U3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MCF.2 cell line derived transforming sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MCF2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7U3"/>
    <dbReference type="Ensembl" id="ENSMODT00000062282.1">
        <property type="protein sequence ID" value="ENSMODP00000056033.1"/>
        <property type="gene ID" value="ENSMODG00000014008.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156974"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014008">
        <property type="expression patterns" value="Expressed in spermatid and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000078">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF146">
        <property type="entry name" value="PROTO-ONCOGENE DBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23289">
        <property type="entry name" value="Spectrin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023812887" evidence="4">
        <location>
            <begin position="19"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="7">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="475"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="673"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="859" mass="98954" checksum="50AC247C3F0EA1F0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7U4</accession>
    <name>A0A5F8H7U4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane and coiled-coil domains 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMCO5A</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7U4"/>
    <dbReference type="Ensembl" id="ENSMODT00000080814.1">
        <property type="protein sequence ID" value="ENSMODP00000055882.1"/>
        <property type="gene ID" value="ENSMODG00000001174.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153380"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001174">
        <property type="expression patterns" value="Expressed in spermatid and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026617">
        <property type="entry name" value="SMCO2/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22422:SF7">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22422">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14992">
        <property type="entry name" value="TMCO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="361" mass="42349" checksum="AB296869D2868A0C" modified="2019-12-11" version="1">MIKVKRIDGVMETTNMNLNRLQEIVEARRTWHAMIHGVTKSDMTQELNNHKRIRLLRYPITRKLLMEEEEQNLSDNESSKKMEILRLEQSKKTLNSLNMDLEKDLQKIDEANQSLLLKIQMEEDVNNRLEDELARLAKLVQEQEKKEQEYTLSDKEQDLKNLKLETSKLLSGKTHAPKALLPAEENLSESPEVAKMKMHQAEKSLAEQEKELAKVLDEFESVQQLCEAQAYCIKKYQEALKKMEEEVENRFLEREVSKVLSISSETARPGLTLVDDIQNDAEMVSVEKKRSLFWYKTLGYLFFTILLFTRLQGYLLFHINHVNPDLILDTLPKMMGRSTLYRLRHFLLPFFTLEAEEVLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7U9</accession>
    <name>A0A5F8H7U9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor A domain containing 3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">VWA3B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000071047.1">
        <property type="protein sequence ID" value="ENSMODP00000055887.1"/>
        <property type="gene ID" value="ENSMODG00000001020.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013149"/>
    <dbReference type="CTD" id="200403"/>
    <dbReference type="GeneTree" id="ENSGT00940000157237"/>
    <dbReference type="OrthoDB" id="10021393at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001020">
        <property type="expression patterns" value="Expressed in spermatocyte and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032770">
        <property type="entry name" value="DUF4537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46785">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46785:SF1">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15057">
        <property type="entry name" value="DUF4537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="573"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1293" mass="147683" checksum="AC70C3E1FD44EAF5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7V0</accession>
    <name>A0A5F8H7V0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Sidekick cell adhesion molecule 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SDK1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the sidekick family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000079188.1">
        <property type="protein sequence ID" value="ENSMODP00000056035.1"/>
        <property type="gene ID" value="ENSMODG00000000232.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157747"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000232">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000202">
        <property type="entry name" value="Sidekick cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000253">
        <property type="entry name" value="Sidekick cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000158">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000177">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000206">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000209">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000231">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000236">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000237">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000261">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000267">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000271">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000301">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000360">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000420">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000434">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000485">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF121">
        <property type="entry name" value="PROTEIN SIDEKICK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1734"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="132"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="226"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="319"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="416"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="517"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="618"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="720"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="818"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="922"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1025"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1126"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1225"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1327"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1430"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1530"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1628"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1801"/>
            <end position="1824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1943" mass="214795" checksum="64DF9B0BB034CB5A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7V1</accession>
    <name>A0A5F8H7V1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Myosin IE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MYO1E</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7V1"/>
    <dbReference type="Ensembl" id="ENSMODT00000084956.1">
        <property type="protein sequence ID" value="ENSMODP00000055281.1"/>
        <property type="gene ID" value="ENSMODG00000008886.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157461"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008886">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11827">
        <property type="entry name" value="SH3_MyoIe_If_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000010">
        <property type="entry name" value="Unconventional myosin-Ie"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035507">
        <property type="entry name" value="Ie/If_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF341">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="14">
        <location>
            <begin position="19"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="15">
        <location>
            <begin position="701"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="955"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="874"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="936"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="889"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="939"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1012" mass="116149" checksum="C6F91208919A7427" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7V2</accession>
    <name>A0A5F8H7V2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MHC class I-like antigen recognition-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7V2"/>
    <dbReference type="Ensembl" id="ENSMODT00000083854.1">
        <property type="protein sequence ID" value="ENSMODP00000055639.1"/>
        <property type="gene ID" value="ENSMODG00000042749.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271825"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000042749">
        <property type="expression patterns" value="Expressed in uterine wall and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF67">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023854781" description="MHC class I-like antigen recognition-like domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="MHC class I-like antigen recognition-like" evidence="4">
        <location>
            <begin position="31"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="340" mass="38613" checksum="C354053FFC32144E" modified="2019-12-11" version="1">MEGQKTRGQFFSAWLLIVGMIVLKDTKAAYHSLEMCFTAVGTTKSLLDFTMVGSMNGVQGSFYGKKNQQLVIKESWVSQALGAQYIEEKRQKLVYNEIDFLWALQNWIQNDTKGESNHTVQFWHDCHLDGDIHMSSHFWYAVDGETFCGINEKLKHWVAMKPEAECFRPFWEVIFPYKKIKRYMEEDCIEPLRKVLKYSSKRENGECVTLGKSLNPHCLALIILLPWNQYTVLILSSSGTLPNADATFYLQVTLELPPGDPGTGYTCVVEHSELETPAMFPVPGKPPMVRPWVMALSILATVILLLSCTVSFKTWKKKKAGTTPQEQLEGPLPLSPLLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7V3</accession>
    <name>A0A5F8H7V3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">28S rRNA (uridine-N(3))-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Centromere protein 32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Kinetochore-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">SPOUT domain-containing methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SPOUT1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N3 position of a uridine in 28S rRNA. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Also involved in chromosome alignment. May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis. Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uridine in 28S rRNA + S-adenosyl-L-methionine = N(3)-methyluridine in 28S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83635"/>
            <dbReference type="Rhea" id="RHEA-COMP:20178"/>
            <dbReference type="Rhea" id="RHEA-COMP:20181"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:83636"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with INCA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7V3"/>
    <dbReference type="Ensembl" id="ENSMODT00000074448.1">
        <property type="protein sequence ID" value="ENSMODP00000056043.1"/>
        <property type="gene ID" value="ENSMODG00000006461.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016537"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006461">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000170">
        <property type="entry name" value="SPOUT domain containing methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="394" mass="44158" checksum="CE5A35F3E9E03742" modified="2019-12-11" version="1">MEMTMLKHSISKKTNYIFYSVYIFGTCSLVLYISLRIFPTSPAFRNSSLRPLLPLSTHQTHEIIHIPHMEIFFPGKEEKKKWRELKMIKKLEKQRAQEEAEKQREEAEETHKQTNGRSYTLSVALPGSILNNAQSPELRTYLAGQIARACAIFCVDEIVVFDEEGEDVKYLRKAFFPKHQDLQFAGLLNPLDSPHHVRQEEVLEYREGIVLDRPTRPGRGSFVNCGMKKEVQIDKNLEPGLRVTVRLDQQQIPESKSLKGRVVSSQEPRTHAGLYWGYSVRLASCLSAVFAEGPYKDGYDLTIGTSERGEGLASIQLPNFNHAIVVFGGLQGLEAGVEADPNLEVTDPSVLFDFYLNTCPGQGSRTIRTEEAILISLATLRPHITGAGAGAGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7V4</accession>
    <name>A0A5F8H7V4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Receptor-type tyrosine-protein phosphatase S</fullName>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Receptor-type tyrosine-protein phosphatase sigma</fullName>
        </alternativeName>
    </protein>
    <organism evidence="36 37">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Synapse</location>
            <location evidence="26">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="Ensembl" id="ENSMODT00000070255.1">
        <property type="protein sequence ID" value="ENSMODP00000055892.1"/>
        <property type="gene ID" value="ENSMODG00000045528.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153617"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000045528">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd05738">
        <property type="entry name" value="IgI_2_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05739">
        <property type="entry name" value="IgI_3_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000549">
        <property type="entry name" value="Protein tyrosine phosphatase, receptor type S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000027">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000036">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000066">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000068">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000144">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000015">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000082">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0966">Cell projection</keyword>
    <keyword evidence="25" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="22" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="24" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="19 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-0675">Receptor</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0770">Synapse</keyword>
    <keyword evidence="9" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="11 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 31" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="1160"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="34">
        <location>
            <begin position="8"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="34">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="34">
        <location>
            <begin position="233"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="35">
        <location>
            <begin position="322"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="35">
        <location>
            <begin position="417"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="35">
        <location>
            <begin position="515"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="35">
        <location>
            <begin position="609"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="35">
        <location>
            <begin position="718"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="35">
        <location>
            <begin position="816"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="35">
        <location>
            <begin position="916"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="32">
        <location>
            <begin position="1240"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="33">
        <location>
            <begin position="1244"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00073611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00079496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1311" mass="145377" checksum="E028434BD6D756B3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7V6</accession>
    <name>A0A5F8H7V6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">GDNF family receptor alpha 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GFRA1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDNFR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7V6"/>
    <dbReference type="Ensembl" id="ENSMODT00000083064.1">
        <property type="protein sequence ID" value="ENSMODP00000055286.1"/>
        <property type="gene ID" value="ENSMODG00000009606.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155560"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009606">
        <property type="expression patterns" value="Expressed in spermatid and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.110:FF:000001">
        <property type="entry name" value="GDNF family receptor alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.110">
        <property type="entry name" value="GDNF binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037193">
        <property type="entry name" value="GDNF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003438">
        <property type="entry name" value="GDNF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003503">
        <property type="entry name" value="GDNF_rcpt_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017372">
        <property type="entry name" value="Glial_neurotroph_fac_rcpt_a1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269:SF3">
        <property type="entry name" value="GDNF FAMILY RECEPTOR ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269">
        <property type="entry name" value="GDNF RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038071">
        <property type="entry name" value="GDNF_family_receptor_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01317">
        <property type="entry name" value="GDNFRALPHA1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01316">
        <property type="entry name" value="GDNFRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00907">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110035">
        <property type="entry name" value="GDNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023883201" evidence="12">
        <location>
            <begin position="24"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="13">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="13">
        <location>
            <begin position="149"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="13">
        <location>
            <begin position="238"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="11">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="11">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="36"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="156"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="182"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="211"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="238"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="245"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="272"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038071-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="497" mass="55372" checksum="12AF7E2EC5E609C4" modified="2019-12-11" version="1">MFLATLYFVLPLVDILLTAEVSGGDHLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLTSGLEAKDECRNAMEALKQKALYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDILRLVPHMPVETISKGNNCLDAAKACNLNDTCKKYRSAYITPCTTSLTNEVCNRRKCHKALRQFFDKVPPKHSYGMLFCSCQDIACTERRRQTIVPLCSYEEKEKPNCLNLQESCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSNSLSVAPWCDCNNSGNDLEECQKFLNFFKDNMCLKNAIQAFGNGSDVNVWQPVLPGQTTTATTTTAFRVRSNKSLGSGSENEISSHVLPPCANLQAQKLKSNASGNPHLCLADVSPCILRYCFGGPGPKVFSAVLGRARGEENPYSFLTQTLSPAILSWYLLSKNELTYQSSGLGGALPMTVLVHRKNHRCSILVNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7V9</accession>
    <name>A0A5F8H7V9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger B-box domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ZBBX</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7V9"/>
    <dbReference type="Ensembl" id="ENSMODT00000061698.1">
        <property type="protein sequence ID" value="ENSMODP00000056045.1"/>
        <property type="gene ID" value="ENSMODG00000025488.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018298"/>
    <dbReference type="OMA" id="FTMGTNC"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025488">
        <property type="expression patterns" value="Expressed in spermatocyte and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19818">
        <property type="entry name" value="Bbox1_ZBBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037688">
        <property type="entry name" value="ZBBX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28634">
        <property type="entry name" value="ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28634:SF1">
        <property type="entry name" value="ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="800"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="822" mass="93759" checksum="9A445B6E7D5DAC4D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7W2</accession>
    <name>A0A5F8H7W2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General vesicular transport factor p115</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein USO1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Transcytosis-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Vesicle-docking protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">USO1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VDP/USO1/EDE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7W2"/>
    <dbReference type="Ensembl" id="ENSMODT00000066050.1">
        <property type="protein sequence ID" value="ENSMODP00000056053.1"/>
        <property type="gene ID" value="ENSMODG00000019208.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017018"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019208">
        <property type="expression patterns" value="Expressed in blood and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000054">
        <property type="entry name" value="General vesicular transport factor p115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041209">
        <property type="entry name" value="P115_Arm_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18770">
        <property type="entry name" value="Arm_vescicular"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="991"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1014"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="19">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="23">
        <location>
            <begin position="348"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="24">
        <location>
            <begin position="854"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="667"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="859"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1039" mass="117066" checksum="25319FE11F1BF80B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7W4</accession>
    <name>A0A5F8H7W4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase phospholipid transporting 8A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ATP8A1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7W4"/>
    <dbReference type="Ensembl" id="ENSMODT00000086148.1">
        <property type="protein sequence ID" value="ENSMODP00000056050.1"/>
        <property type="gene ID" value="ENSMODG00000020583.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157110"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020583">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF221">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE IA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="1">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="214" mass="24591" checksum="61A8079756BC2AAF" modified="2019-12-11" version="1">MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEIRTIFLNQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKSGSLSSLPEAAFAFFLVSATEEMVERKFLICSTSANSETFRCWKGLWNILEHPFIKGRTPEDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7W5</accession>
    <name>A0A5F8H7W5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4 gamma 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">EIF4G3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000078925.1">
        <property type="protein sequence ID" value="ENSMODP00000055296.1"/>
        <property type="gene ID" value="ENSMODG00000015988.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156454"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015988">
        <property type="expression patterns" value="Expressed in testis and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11559">
        <property type="entry name" value="W2_eIF4G1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 4 gamma, 3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 4 gamma, 3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000003">
        <property type="entry name" value="Putative eukaryotic translation initiation factor 4 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF23">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MI" evidence="9">
        <location>
            <begin position="1279"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="W2" evidence="8">
        <location>
            <begin position="1474"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1130"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1162"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="919"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1162"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1200"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1243"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1643" mass="182124" checksum="FF61461848E2B86D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7W6</accession>
    <name>A0A5F8H7W6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dorsal inhibitory axon guidance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DRAXIN</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7W6"/>
    <dbReference type="Ensembl" id="ENSMODT00000075348.1">
        <property type="protein sequence ID" value="ENSMODP00000055902.1"/>
        <property type="gene ID" value="ENSMODG00000010996.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013828"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010996">
        <property type="expression patterns" value="Expressed in spinal cord and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029094">
        <property type="entry name" value="Draxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28610">
        <property type="entry name" value="DRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28610:SF1">
        <property type="entry name" value="DRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15550">
        <property type="entry name" value="Draxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023889708" evidence="6">
        <location>
            <begin position="28"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="284" mass="31664" checksum="6876F6788495D9FE" modified="2019-12-11" version="1">MAGSPSCLSPVLLLWILVLSDPSFAGALESAPKESNVPENNIHQQSPELWQPRARHARKHGLNKKGRSHMADRAGASRMPGMLPRGEELLAVQGPAGLMQDKDVFLGFEFPYPERDNRFERGRKSTREHKRRRDRAKTHRGRSLDPKPSSLIKKVEFSEDLASNAPMEESSTSLAPTILFLTTFETAASTEESPVLPVTSPRPQARIRPDGDVMPTLDMALFDWTDYEDLKPDMWPSAKKKEKHQSKSLGYTNETSAAREEPCDHHLDCLPGTTSPSQQGNFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7W8</accession>
    <name>A0A5F8H7W8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Epithelial mitogen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EPGN</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7W8"/>
    <dbReference type="Ensembl" id="ENSMODT00000065761.1">
        <property type="protein sequence ID" value="ENSMODP00000056058.1"/>
        <property type="gene ID" value="ENSMODG00000043502.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048556"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000043502">
        <property type="expression patterns" value="Expressed in cerebellum and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="71" mass="8179" checksum="69CF7A9D437E6072" modified="2019-12-11" version="1">MALGIPWYILLNAEYTEGPIALKFSHTCLADHHSYCINGICVFHHELKKATCRYMKLKPPYKVCSGERRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7W9</accession>
    <name>A0A5F8H7W9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine rich hydrophobic domain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CHIC2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7W9"/>
    <dbReference type="SMR" id="A0A5F8H7W9"/>
    <dbReference type="Ensembl" id="ENSMODT00000069751.1">
        <property type="protein sequence ID" value="ENSMODP00000056055.1"/>
        <property type="gene ID" value="ENSMODG00000020667.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003601"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020667">
        <property type="expression patterns" value="Expressed in spermatid and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039735">
        <property type="entry name" value="CHIC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13005">
        <property type="entry name" value="CYSTEINE-RICH HYDROPHOBIC DOMAIN PROTEIN BRAIN X-LINKED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13005:SF3">
        <property type="entry name" value="CYSTEINE-RICH HYDROPHOBIC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="3">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="146" mass="16787" checksum="B186A4E2E3186D5A" modified="2019-12-11" version="1">MADFDEIYEEEEDEERALEEQLLKYSPDPVVVRGSGHVTVFGLSNKFESEFPSSLTGKVAPEEFKASINRVNSCLKKNLPVNVRWLLCGCLCCCCTLGCSMWPVICLSKRLCLHWRLSKRKCETNNMMEYVILIEFLPKTPIFRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H864</accession>
    <name>A0A5F8H864_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-galactoside alpha-2,6-sialyltransferase 2</fullName>
            <ecNumber evidence="18">2.4.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">ST6Gal II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sialyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ST6GAL2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;6)-beta-D-galactosyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28034"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:136398"/>
            <dbReference type="EC" id="2.4.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.1" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H864"/>
    <dbReference type="Ensembl" id="ENSMODT00000068859.1">
        <property type="protein sequence ID" value="ENSMODP00000056155.1"/>
        <property type="gene ID" value="ENSMODG00000002618.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158714"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002618">
        <property type="expression patterns" value="Expressed in spinal cord and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003835">
        <property type="term" value="F:beta-galactoside alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23986">
        <property type="entry name" value="GT29_ST6GAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000010">
        <property type="entry name" value="ST6 beta-galactoside alpha-2,6-sialyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46059">
        <property type="entry name" value="BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46059:SF3">
        <property type="entry name" value="BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="539" mass="62376" checksum="2D33AB185740052F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H869</accession>
    <name>A0A5F8H869_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Selenocysteine lyase</fullName>
            <ecNumber evidence="10">4.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SCLY</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.16" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H869"/>
    <dbReference type="Ensembl" id="ENSMODT00000075928.1">
        <property type="protein sequence ID" value="ENSMODP00000056163.1"/>
        <property type="gene ID" value="ENSMODG00000015913.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157773"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015913">
        <property type="expression patterns" value="Expressed in lung and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009000">
        <property type="term" value="F:selenocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000083">
        <property type="entry name" value="Selenocysteine lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000065">
        <property type="entry name" value="Selenocysteine lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF62">
        <property type="entry name" value="SELENOCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="35"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="139"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="423" mass="45133" checksum="FC7DDD2F56D64821" modified="2019-12-11" version="1">MEEAAAATAVRKSAGSPPVPGESGGDKTRPQERKVYMDYNATTPLEPDVIQAITEALQEAWGNPSSPYLPGRKAKEIINAARENLAKMVGGKPQDLIFTSGGTEANNLVIHSSVKLFQESQQGRQDGPAEQPPGLGHGAKPHIVTCSVEHDSIRLPLEHLAREHVAEVTFVPVSKLNGQAEADDVLAAIRPSTCLVTIMLANNETGVIMPVSDICRRIKTLNQSRAASGLPVIRVHTDAAQALGKRRVDVQELGVDYLTIVGHKFYGPRIGALYVRGLGVVTPLRPMLFGGGQEWSFRPGTENTAMIAGLGKAVFEKRIHLNSHFAGSDRLSNTCNFSIAGPHLQGRLVLARCGTLLASVGAACHSDQGDLPSPILLSCGIPLDVARNAIRLSVGRTTTREDVELAVEDLRQAVTQLEKGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H871</accession>
    <name>A0A5F8H871_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MHC class II family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H871"/>
    <dbReference type="Ensembl" id="ENSMODT00000059791.1">
        <property type="protein sequence ID" value="ENSMODP00000055997.1"/>
        <property type="gene ID" value="ENSMODG00000046464.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161821"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002504">
        <property type="term" value="P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05767">
        <property type="entry name" value="IgC1_MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.320.10">
        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001003">
        <property type="entry name" value="MHC_II_a_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF59">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00993">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00920">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0491">MHC II</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="114"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="264" mass="29670" checksum="7105012D89F44A76" modified="2019-12-11" version="1">MSSAKSDNLVSSLPILMPSISFSSLIATATDHMDTFGTTVYQSYGPSGQYTNDFDEDELFYVDLKKKETVWRLPEFGNFAKFDPWGGLRNSAMMKNILDLLMRKSNYTADPNVPEVTVFSRTPIELGQPNTLICFINNIFPPVINITWQQNGQRVTTGVMETNFYPQTDNSFQKLSYLTFIPSTEDVYGCKVEHWGFEKSLLKHWGKESFIQLHSQWSTTETLTCALKLTVGLLGIIVSTILIARSMIGTAVLTLGLKSPYESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H872</accession>
    <name>A0A5F8H872_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrosomal protein 128</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CEP128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_056666588.1">
        <property type="nucleotide sequence ID" value="XM_056810610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H872"/>
    <dbReference type="Ensembl" id="ENSMODT00000067085.1">
        <property type="protein sequence ID" value="ENSMODP00000055764.1"/>
        <property type="gene ID" value="ENSMODG00000004554.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021501"/>
    <dbReference type="CTD" id="145508"/>
    <dbReference type="GeneTree" id="ENSGT00390000007020"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004554">
        <property type="expression patterns" value="Expressed in testis and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026652">
        <property type="entry name" value="CEP128"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46657">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 128 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46657:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 128 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="744"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="907"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1059" mass="125498" checksum="8379074EB80B2B5C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H874</accession>
    <name>A0A5F8H874_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibroblast growth factor</fullName>
            <shortName evidence="3">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FGF10</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H874"/>
    <dbReference type="Ensembl" id="ENSMODT00000078566.1">
        <property type="protein sequence ID" value="ENSMODP00000056168.1"/>
        <property type="gene ID" value="ENSMODG00000050618.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158907"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000050618">
        <property type="expression patterns" value="Expressed in spermatid and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000004">
        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0339">Growth factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023976469" description="Fibroblast growth factor" evidence="3">
        <location>
            <begin position="37"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="209" mass="23429" checksum="BAF6DC06184AAD63" modified="2019-12-11" version="1">MWKWILTHGASAFPHLPCCCCCFLLLFLVSSVPVNCHGMGQDMLSPEATNSSSSSSSSSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKNENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSREFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H875</accession>
    <name>A0A5F8H875_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CD80 molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CD80</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H875"/>
    <dbReference type="Ensembl" id="ENSMODT00000068678.1">
        <property type="protein sequence ID" value="ENSMODP00000055401.1"/>
        <property type="gene ID" value="ENSMODG00000018199.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162632"/>
    <dbReference type="OMA" id="HMTSVML"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018199">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000910">
        <property type="entry name" value="T-lymphocyte activation antigen CD80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF4">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN CD80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="37"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="170"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="289" mass="32955" checksum="7A7C39A9651B8E2A" modified="2019-12-11" version="1">MRCGSYCNLEKKRKELVFDLRHLEGNLPGLELRMAQPKLLHFMLLCLLYMAHAGLSSGETKVTRAVKEAVTFPCNYEIPEKERTYYRVYWQHDTKVVQAYVPGRRGEDLIDLSYVNRTVMEMANNLSVTIFPLQVPDEGTYECIVQRLVGGQYKRVHKQDVQLSISADFPEPTTEVYEETGYWRMTCSSRQGYPQPKLSWVNNGKVLTSVNTSIFQDPVTKLYDIQSELHINQTNNSLFICSIDYGDSRVSANVTLPKGPDSWSGALIIAATLPSIFFLIAMILLVYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H876</accession>
    <name>A0A5F8H876_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="15">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PLCZ1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H876"/>
    <dbReference type="Ensembl" id="ENSMODT00000061287.1">
        <property type="protein sequence ID" value="ENSMODP00000056002.1"/>
        <property type="gene ID" value="ENSMODG00000017890.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159950"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017890">
        <property type="expression patterns" value="Expressed in spermatid and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF29">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0278">Fertilization</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="18">
        <location>
            <begin position="286"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="402"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="542" mass="62588" checksum="E5095469B66081BB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H879</accession>
    <name>A0A5F8H879_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding motif single stranded interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RBMS1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H879"/>
    <dbReference type="FunCoup" id="A0A5F8H879">
        <property type="interactions" value="961"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000056173"/>
    <dbReference type="Ensembl" id="ENSMODT00000064702.1">
        <property type="protein sequence ID" value="ENSMODP00000056173.1"/>
        <property type="gene ID" value="ENSMODG00000005250.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156082"/>
    <dbReference type="InParanoid" id="A0A5F8H879"/>
    <dbReference type="OMA" id="TMEHTMS"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005250">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12470">
        <property type="entry name" value="RRM1_MSSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12473">
        <property type="entry name" value="RRM2_MSSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000012">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000014">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034404">
        <property type="entry name" value="MSSP1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="98"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="177"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="439" mass="48664" checksum="6FFD9DE57B6746C6" modified="2019-12-11" version="1">MWNCCHYLQYIFRYFTLIFKYSENVYSFFHRLVCRKGVWRLTAQELVFHSQINWKTEATSQQSIVPAHPMAPPSPSTTSSNNNSSNSSSSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKATGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPAEPLLCKFADGGQKKRQNQNKYIQNGRAWHREGEAGMTLTYDPTTAALQNGFYPSPYSIATNRMITQTSITPYIASPVSTYQVQSPSWMQPQPYILQHPGAVLTPSMDHTMSLQPTSMISPLAQQMSHLSLGNTGTYMPATTAMQGAYIPQYTHVQTAAVPVEEASGQQQVAVETSSDHSPYTYQQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H881</accession>
    <name>A0A5F8H881_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100024553</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H881"/>
    <dbReference type="Ensembl" id="ENSMODT00000068793.1">
        <property type="protein sequence ID" value="ENSMODP00000055406.1"/>
        <property type="gene ID" value="ENSMODG00000039015.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162725"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000039015">
        <property type="expression patterns" value="Expressed in spinal cord and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002573">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003131">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002519">
        <property type="entry name" value="zinc finger protein 252-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000629">
        <property type="entry name" value="zinc finger protein 333 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000801">
        <property type="entry name" value="zinc finger protein 461 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001402">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002235">
        <property type="entry name" value="Zinc finger protein 549"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000592">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000057">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF96">
        <property type="entry name" value="ZINC FINGER PROTEIN 420-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="17">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="804" mass="91903" checksum="32B0E7EEC5C90E3B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H884</accession>
    <name>A0A5F8H884_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="20">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ATP2C1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:18106"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Mn(2+)(in) + ATP + H2O = Mn(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66821"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer. Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="20"/>
    <dbReference type="RefSeq" id="XP_007505174.1">
        <property type="nucleotide sequence ID" value="XM_007505112.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007505175.1">
        <property type="nucleotide sequence ID" value="XM_007505113.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056656232.1">
        <property type="nucleotide sequence ID" value="XM_056800254.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056656233.1">
        <property type="nucleotide sequence ID" value="XM_056800255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H884"/>
    <dbReference type="Ensembl" id="ENSMODT00000083413.1">
        <property type="protein sequence ID" value="ENSMODP00000055774.1"/>
        <property type="gene ID" value="ENSMODG00000011991.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100030308"/>
    <dbReference type="CTD" id="27032"/>
    <dbReference type="GeneTree" id="ENSGT00940000156421"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011991">
        <property type="expression patterns" value="Expressed in spinal cord and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02085">
        <property type="entry name" value="P-type_ATPase_SPCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000017">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000106">
        <property type="entry name" value="E1-E2 ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 20" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="844"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="873"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="902"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="911"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="924" mass="101107" checksum="C6BB283E8586EF87" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H888</accession>
    <name>A0A5F8H888_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">POU6F1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the POU transcription factor family. Class-6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H888"/>
    <dbReference type="Ensembl" id="ENSMODT00000070152.1">
        <property type="protein sequence ID" value="ENSMODP00000056180.1"/>
        <property type="gene ID" value="ENSMODG00000018676.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160106"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018676">
        <property type="expression patterns" value="Expressed in cerebellum and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000051">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000013">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF6">
        <property type="entry name" value="POU DOMAIN, CLASS 6, TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="14">
        <location>
            <begin position="295"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="388"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="390"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="457" mass="48431" checksum="61EE9E3971D3E2AB" modified="2019-12-11" version="1">MPSSLPLPSGPPRPACLLPRVCQCLWEWNESGGQQDISAPLSLPCSLAAAVLNTALPAPVPPAPPLQVPPPVQPRPSAAQAQTLFQPQPLLQTPPAILPQPAATPAPKPADTPTQITVQPAGFAFNPGIISAASLGGQTQILGSLTTTPVIANAIPSVPGITSQILTNAQGQVIGTLPWVVNSASLAAPAPAQNLQVQAVTPQLLLNAQGQVIATLASSPLPPAAVRKPSTPESPAKSEVQPIQPTPAASQPAVVITSPAPVAKPSASAPIPITCSETPTVSQLVSKPQAPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H889</accession>
    <name>A0A5F8H889_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transcription initiation factor TFIID 18 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TAF13</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TBP, and more strongly with TAF10 and TAF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016284555.1">
        <property type="nucleotide sequence ID" value="XM_016429069.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H889"/>
    <dbReference type="Ensembl" id="ENSMODT00000053796.1">
        <property type="protein sequence ID" value="ENSMODP00000055779.1"/>
        <property type="gene ID" value="ENSMODG00000002205.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100029947"/>
    <dbReference type="CTD" id="6884"/>
    <dbReference type="GeneTree" id="ENSGT00390000012981"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002205">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000028">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="116" mass="13302" checksum="1D20EC8E2B08DFDD" modified="2019-12-11" version="1">MFEEDNDDAGGGADGGQGKRKRLFSKELRCMMYGFGDDQNPYTESVDILEDLVIEFITEMTHKAMSIGRQGRVQVEDIVFLIRKDPRKFARVKDLLTMNEELKRARKAFDEANYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F6QAB2</accession>
    <name>F6QAB2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ninjurin 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ninjurin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6QAB2"/>
    <dbReference type="Ensembl" id="ENSMODT00000023353.4">
        <property type="protein sequence ID" value="ENSMODP00000022947.4"/>
        <property type="gene ID" value="ENSMODG00000018399.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S2EJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158219"/>
    <dbReference type="HOGENOM" id="CLU_093971_2_0_1"/>
    <dbReference type="OMA" id="WRFYALE"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018399">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007007">
        <property type="entry name" value="Ninjurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316:SF24">
        <property type="entry name" value="NINJURIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316">
        <property type="entry name" value="NINJURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04923">
        <property type="entry name" value="Ninjurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000022947.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="207" mass="23751" checksum="DBC1B500B5A8B9F1" modified="2019-12-11" version="3">MAVRYVKMEFLQIPGRVQSQEYLFSLCNDLRCPWRFYALEISSLLHLPATLKILSRRQTCSYKWSLSCFHLLVHSPGPRNPSPRRDLPINFNHYTTKKSVSESMLDVALFMSNATRLKAVLERGPLSPYYTILVTLLSISLLLQVVIGILLIITARMNLNEVSKQQRLNQLNNTTMAMVFITVIINIFITAFGVQKMGQSWPTPKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F6WT41</accession>
    <name>F6WT41_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin filament-associated protein 1-like 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AFAP1L2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with SRC. Interacts with LCK when tyrosine phosphorylated.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007479027.1">
        <property type="nucleotide sequence ID" value="XM_007478965.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6WT41"/>
    <dbReference type="Ensembl" id="ENSMODT00000012421.4">
        <property type="protein sequence ID" value="ENSMODP00000012196.3"/>
        <property type="gene ID" value="ENSMODG00000009761.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100027276"/>
    <dbReference type="KEGG" id="mdo:100027276"/>
    <dbReference type="CTD" id="84632"/>
    <dbReference type="eggNOG" id="ENOG502QQA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183067"/>
    <dbReference type="HOGENOM" id="CLU_014418_0_0_1"/>
    <dbReference type="OrthoDB" id="8443615at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009761">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13306">
        <property type="entry name" value="PH1_AFAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13307">
        <property type="entry name" value="PH2_AFAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000020">
        <property type="entry name" value="Actin filament-associated protein 1-like 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000171">
        <property type="entry name" value="Actin filament-associated protein 1-like 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030113">
        <property type="entry name" value="AFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14338">
        <property type="entry name" value="ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14338:SF4">
        <property type="entry name" value="ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="199"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="377"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="698"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000012196.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="858" mass="96957" checksum="C8ACE04E94797E09" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F6X533</accession>
    <name>F6X533_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomal protein 126</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CEP126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F6X533"/>
    <dbReference type="Ensembl" id="ENSMODT00000000687.4">
        <property type="protein sequence ID" value="ENSMODP00000000672.4"/>
        <property type="gene ID" value="ENSMODG00000000558.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QR78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013786"/>
    <dbReference type="HOGENOM" id="CLU_010202_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000558">
        <property type="expression patterns" value="Expressed in spermatocyte and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028257">
        <property type="entry name" value="CEP126"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31191">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31191:SF4">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 126 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15352">
        <property type="entry name" value="K1377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="927"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000000672.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1103" mass="125703" checksum="2BED319CED2336C4" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F6X549</accession>
    <name>F6X549_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptidyl peptidase like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DPP10</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6X549"/>
    <dbReference type="MEROPS" id="S09.974"/>
    <dbReference type="Ensembl" id="ENSMODT00000000685.3">
        <property type="protein sequence ID" value="ENSMODP00000000670.3"/>
        <property type="gene ID" value="ENSMODG00000000555.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154657"/>
    <dbReference type="HOGENOM" id="CLU_006105_4_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000555">
        <property type="expression patterns" value="Expressed in spinal cord and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF21">
        <property type="entry name" value="INACTIVE DIPEPTIDYL PEPTIDASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="4">
        <location>
            <begin position="445"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000000670.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="661" mass="75447" checksum="84725558F249CD01" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>F7AMM8</accession>
    <name>F7AMM8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gasdermin pore forming domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Homooligomer; homooligomeric ring-shaped pore complex containing 27-28 subunits when inserted in the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gasdermin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7AMM8"/>
    <dbReference type="Ensembl" id="ENSMODT00000002040.2">
        <property type="protein sequence ID" value="ENSMODP00000001998.2"/>
        <property type="gene ID" value="ENSMODG00000001632.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183140"/>
    <dbReference type="HOGENOM" id="CLU_1059789_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001632">
        <property type="expression patterns" value="Expressed in placenta and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007677">
        <property type="entry name" value="Gasdermin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040460">
        <property type="entry name" value="Gasdermin_pore"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16399">
        <property type="entry name" value="GASDERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16399:SF21">
        <property type="entry name" value="GASDERMIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04598">
        <property type="entry name" value="Gasdermin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gasdermin pore forming" evidence="6">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000001998.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="244" mass="27475" checksum="4D6CFDD951A25E5A" modified="2019-12-11" version="2">MPSMFKTMAKSLVKEVGKKDLNPVSNLSSSHRFRPFCLLRKKSKKHKFWSKKFTCTEFSLMDILEPNSPVPEVNQERQFHFCKKVDGKLMGAMGLDMEKKIDMNIGVSAGIEKSHGSFLEMQILTISYQTWTTLQMERKLVKPEPTFIGELRSRGEDLYVVIEAMELVNSPVLGSKITLRGAGSISFPELVNVEGQGHGSRGKQKLMTIPPHSILAYRAAKLSISENSWDSEDESKTGEEFLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F7C1N2</accession>
    <name>F7C1N2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch like family member 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KLHL26</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007489313.2">
        <property type="nucleotide sequence ID" value="XM_007489251.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007489314.1">
        <property type="nucleotide sequence ID" value="XM_007489252.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007489315.1">
        <property type="nucleotide sequence ID" value="XM_007489253.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007489316.1">
        <property type="nucleotide sequence ID" value="XM_007489254.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056678128.1">
        <property type="nucleotide sequence ID" value="XM_056822150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7C1N2"/>
    <dbReference type="Ensembl" id="ENSMODT00000033881.3">
        <property type="protein sequence ID" value="ENSMODP00000032302.3"/>
        <property type="gene ID" value="ENSMODG00000003568.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100015959"/>
    <dbReference type="CTD" id="55295"/>
    <dbReference type="GeneTree" id="ENSGT00940000159238"/>
    <dbReference type="HOGENOM" id="CLU_604913_0_0_1"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003568">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7C1N2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="CDD" id="cd18465">
        <property type="entry name" value="BACK_KLHL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18255">
        <property type="entry name" value="BTB_POZ_KLHL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030588">
        <property type="entry name" value="BTB_POZ_KLHL26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF13">
        <property type="entry name" value="KELCH-LIKE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000032302.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="588" mass="66284" checksum="E7E9E517D2E2B0B3" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F7C200</accession>
    <name>F7C200_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mth938 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">AAMDC</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May play a role in preadipocyte differentiation and adipogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAMDC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7C200"/>
    <dbReference type="FunCoup" id="F7C200">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000006037"/>
    <dbReference type="Ensembl" id="ENSMODT00000006165.3">
        <property type="protein sequence ID" value="ENSMODP00000006037.3"/>
        <property type="gene ID" value="ENSMODG00000004901.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011958"/>
    <dbReference type="HOGENOM" id="CLU_074390_4_1_1"/>
    <dbReference type="InParanoid" id="F7C200"/>
    <dbReference type="OMA" id="AEYNKMA"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004901">
        <property type="expression patterns" value="Expressed in heart and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05126">
        <property type="entry name" value="Mth938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000001">
        <property type="entry name" value="Adipogenesis-associated, Mth938 domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034096">
        <property type="entry name" value="AAMDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15811">
        <property type="entry name" value="MTH938 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15811:SF5">
        <property type="entry name" value="MTH938 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00057418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000006037.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="136" mass="14922" checksum="26209B5EBB6918DB" modified="2019-12-11" version="2">MQSERNRTRRTISIMSSPKIASLSWGQMKVQDCSTTYKDCKVWPGGSRSWDWRETGTEHSPGVQPADVEEVAKKGVQTLVIGHGMSEALKVPASTVDYLKKQGINVLVLQTEQAVKEYNALAAQGVRVGGVFHSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F7C205</accession>
    <name>F7C205_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small glutamine-rich tetratricopeptide repeat-containing protein alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-SGT</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Homooligomer. Interacts with DNAJC5 and DNAJC5B. Interacts (via TPR repeats) with HSP90AA1. Interacts (via Gln-rich region) with SLC2A1. Interacts with HSP90AB1. Interacts (via TPR repeats) with HSPA8/Hsc70; the interaction is direct. Interacts with BAG6 (via ubiquitin-like domain); interaction prevents interaction between BAG6 and RNF126. Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SGT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7C205"/>
    <dbReference type="Ensembl" id="ENSMODT00000006164.3">
        <property type="protein sequence ID" value="ENSMODP00000006036.1"/>
        <property type="gene ID" value="ENSMODG00000004900.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100020424"/>
    <dbReference type="eggNOG" id="KOG0553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159037"/>
    <dbReference type="HOGENOM" id="CLU_044224_0_0_1"/>
    <dbReference type="OMA" id="PHNAVYF"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004900">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000002">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000108">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF3">
        <property type="entry name" value="SMALL GLUTAMINE-RICH TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="17">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000006036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="276" mass="29978" checksum="8635A66BA8715DD3" modified="2011-07-27" version="1">MEDKKRLAYSIIQFLHDQLHHGCLSPDAQESLEVAIQCLETAFGVTVEDRDLAVSQTLPQIFEAATGKKEMPYIRRNSEPIPPSDEDTAEAERLKTEGNEQMKIENFEAAVSFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVRDCERAIGIDPYYSKAYGRMGLALSSLNKHTEAVVYYKKALELDPDNDTYKSNLKIAEQKMKETPSPTGGTGGFDLAGLLNNPGFMSMASNLMNNPQVQQLMSGMISGGHNPLGGAGASPSPNDLASLIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F7D4T0</accession>
    <name>F7D4T0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger CCHC-type containing 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ZCCHC24</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F7D4T0"/>
    <dbReference type="Ensembl" id="ENSMODT00000001378.4">
        <property type="protein sequence ID" value="ENSMODP00000001350.3"/>
        <property type="gene ID" value="ENSMODG00000001134.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008264"/>
    <dbReference type="HOGENOM" id="CLU_081736_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001134">
        <property type="expression patterns" value="Expressed in liver and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033446">
        <property type="entry name" value="ZCCHC24_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17180">
        <property type="entry name" value="Zn_ribbon_3CxxC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000001350.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="232" mass="25629" checksum="D8DFFFA93AD45287" modified="2019-12-11" version="2">MSLLSAIDTSAASVYQPAQLLNWVYLSLQDTHQASAFDAFRPEPAGASHPELGYGKGSPEQLGSPLNSSYLNSFLQLQRGEALSSSLYKSASPYGSLNNIVDGLSSLTEHFSDLSLSSEARKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKRSEGERAGTIFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>F7D527</accession>
    <name>F7D527_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TRIM2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="F7D527"/>
    <dbReference type="Ensembl" id="ENSMODT00000001370.4">
        <property type="protein sequence ID" value="ENSMODP00000001342.4"/>
        <property type="gene ID" value="ENSMODG00000001127.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155905"/>
    <dbReference type="HOGENOM" id="CLU_008645_5_0_1"/>
    <dbReference type="OMA" id="ECRLRFG"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001127">
        <property type="expression patterns" value="Expressed in spinal cord and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19824">
        <property type="entry name" value="Bbox2_TRIM2_C-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000032">
        <property type="entry name" value="Tripartite motif containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000198">
        <property type="entry name" value="Tripartite motif-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000154">
        <property type="entry name" value="Tripartite motif-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="13">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="10">
        <location>
            <begin position="320"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000001342.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="476" mass="52841" checksum="32CAF71C4B6AD0AB" modified="2019-12-11" version="3">MASEGSNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVSALQNNFFITNLMDVLQRTPGSNTEESSILETVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEIDSALHFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQTQLDTLLEGQENIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLQPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTVIGQPMSVTITTKDKDGELCKSGNAYITAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>F7EZ88</accession>
    <name>F7EZ88_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dedicator of cytokinesis 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000008144.5">
        <property type="protein sequence ID" value="ENSMODP00000007981.5"/>
        <property type="gene ID" value="ENSMODG00000006428.5"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159313"/>
    <dbReference type="HOGENOM" id="CLU_000624_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006428">
        <property type="expression patterns" value="Expressed in heart and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08696">
        <property type="entry name" value="C2_Dock-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000002">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000022">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037808">
        <property type="entry name" value="C2_Dock-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF65">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="5">
        <location>
            <begin position="714"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="6">
        <location>
            <begin position="1817"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1012"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1105"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1452"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2110"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1012"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1115"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2113"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2172"/>
            <end position="2184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000007981.5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2184" mass="243282" checksum="7A975D8FC9A8E251" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4P0</accession>
    <name>A0A5F8G4P0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ubiquilin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UBQLN1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007498983.1">
        <property type="nucleotide sequence ID" value="XM_007498921.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4P0"/>
    <dbReference type="Ensembl" id="ENSMODT00000076364.1">
        <property type="protein sequence ID" value="ENSMODP00000042410.1"/>
        <property type="gene ID" value="ENSMODG00000008558.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021674"/>
    <dbReference type="CTD" id="29979"/>
    <dbReference type="GeneTree" id="ENSGT00940000156437"/>
    <dbReference type="OrthoDB" id="9450922at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008558">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01808">
        <property type="entry name" value="Ubl_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000001">
        <property type="entry name" value="Ubiquilin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000003">
        <property type="entry name" value="Ubiquilin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000007">
        <property type="entry name" value="Ubiquilin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000081">
        <property type="entry name" value="ubiquilin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF16">
        <property type="entry name" value="UBIQUILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="11">
        <location>
            <begin position="514"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="287"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="453"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="557" mass="59418" checksum="EC7E5A861256B2D3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4P1</accession>
    <name>A0A5F8G4P1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sp4 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SP4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001370863.1">
        <property type="nucleotide sequence ID" value="XM_001370826.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4P1"/>
    <dbReference type="FunCoup" id="A0A5F8G4P1">
        <property type="interactions" value="2708"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000059662.1">
        <property type="protein sequence ID" value="ENSMODP00000042443.1"/>
        <property type="gene ID" value="ENSMODG00000001368.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100017240"/>
    <dbReference type="KEGG" id="mdo:100017240"/>
    <dbReference type="CTD" id="6671"/>
    <dbReference type="GeneTree" id="ENSGT00940000157827"/>
    <dbReference type="InParanoid" id="A0A5F8G4P1"/>
    <dbReference type="OMA" id="NQQAILP"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001368">
        <property type="expression patterns" value="Expressed in cerebellum and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22536">
        <property type="entry name" value="SP4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000061">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039938">
        <property type="entry name" value="Sp4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14947:SF23">
        <property type="entry name" value="SP4 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14947">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="675"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="705"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="304"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="812" mass="84458" checksum="B07C23D0E7A82263" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4P2</accession>
    <name>A0A5F8G4P2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 831</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000072152.1">
        <property type="protein sequence ID" value="ENSMODP00000042422.1"/>
        <property type="gene ID" value="ENSMODG00000047827.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000171292"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000047827">
        <property type="expression patterns" value="Expressed in blood and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47166">
        <property type="entry name" value="ZINC FINGER PROTEIN 831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47166:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="698"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="913"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1054"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1131"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1407"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1490"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1786"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1138"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1413"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1495"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1532"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1546"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1569"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1786"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1806"/>
            <end position="1819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1834" mass="197551" checksum="DE5FADEE4833A988" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4P4</accession>
    <name>A0A5F8G4P4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 260-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100029038</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4P4"/>
    <dbReference type="Ensembl" id="ENSMODT00000057866.1">
        <property type="protein sequence ID" value="ENSMODP00000042409.1"/>
        <property type="gene ID" value="ENSMODG00000010852.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182890"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010852">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004137">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001255">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000101">
        <property type="entry name" value="zinc finger protein 436 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001509">
        <property type="entry name" value="Zinc finger protein 616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="45"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="737" mass="86434" checksum="527F7279D70092D4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4P7</accession>
    <name>A0A5F8G4P7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Vomeronasal 2 receptor 604</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">VN2R565</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4P7"/>
    <dbReference type="Ensembl" id="ENSMODT00000087938.1">
        <property type="protein sequence ID" value="ENSMODP00000042427.1"/>
        <property type="gene ID" value="ENSMODG00000041124.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154249"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000041124">
        <property type="expression patterns" value="Expressed in digestive system and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06365">
        <property type="entry name" value="PBP1_pheromone_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000125">
        <property type="entry name" value="Vomeronasal 2, receptor 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF545">
        <property type="entry name" value="VOMERONASAL 2, RECEPTOR 118-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="504"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="770" mass="86539" checksum="28C9E256A7CA2744" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4P8</accession>
    <name>A0A5F8G4P8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Amiloride-sensitive sodium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4P8"/>
    <dbReference type="Ensembl" id="ENSMODT00000055619.1">
        <property type="protein sequence ID" value="ENSMODP00000042414.1"/>
        <property type="gene ID" value="ENSMODG00000037213.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160952"/>
    <dbReference type="OMA" id="RSYRELX"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000037213">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034706">
        <property type="term" value="C:sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000002">
        <property type="entry name" value="Amiloride-sensitive sodium channel subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF124">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 17" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="12 17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="245"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33072" checksum="9A85FBE6AE12071F" modified="2019-12-11" version="1">MVHGQDEPPFMDDGGFNLRPGVETSISMRKETLDRLGGNYGDCTNNGSEIQVENIYFSKYTQQVCIHSCFQESMIRECGCAYMSYPKRDGVEFCDYKKHTAWGYCYYKLQVAFSSDNLGCFAKCRKPCSVTNYQLSAGYSRWPSATSQDWVFQMLSLQNNYTISSKSGVAKLNIFFKELNYKANSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELIFDFLVITFFLLLRRLRSRYWAPGHPPQGSQEVAMESSPPSRFSCHSGASSDQLGPESSAPVPPPAYATLSPPSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4P9</accession>
    <name>A0A5F8G4P9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear pore complex protein Nup50</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">50 kDa nucleoporin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Nuclear pore-associated protein 60 kDa-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Nucleoporin Nup50</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">NUP50</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with regulatory proteins of cell cycle progression including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_001363984.1">
        <property type="nucleotide sequence ID" value="XM_001363947.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4P9"/>
    <dbReference type="Ensembl" id="ENSMODT00000082877.1">
        <property type="protein sequence ID" value="ENSMODP00000042420.1"/>
        <property type="gene ID" value="ENSMODG00000007116.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013757"/>
    <dbReference type="KEGG" id="mdo:100013757"/>
    <dbReference type="CTD" id="10762"/>
    <dbReference type="GeneTree" id="ENSGT00440000035348"/>
    <dbReference type="OMA" id="CDWVWEQ"/>
    <dbReference type="OrthoDB" id="10062131at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007116">
        <property type="expression patterns" value="Expressed in testis and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13170">
        <property type="entry name" value="RanBD_NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000179">
        <property type="entry name" value="Nuclear pore complex protein Nup50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF141">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RanBD1" evidence="21">
        <location>
            <begin position="315"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="208"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="473" mass="50230" checksum="55A2A17400687BE7" modified="2019-12-11" version="1">MAKRNAEKELTDRNWDQEDEVEEVGMFSVASEEVLKNRAIKKAKRRNVAFESESGGAFKGFKGLVVPPGGPGGGGGLAGFGNGTSIKSLEGLSNGSGLSCAPTLATAKAPSETKVTFGRITANGPAAPLVGDKKTSNPKSNGDSQQPSSSGHSVQAKGGCSASAYHKQLAALNCSVRDWIVKHVDTNPLCDLTPIFKDYERYLTSIEQLPGSSSSNDGNLEKEASRQSPGTQAGPPPQDTPFLFHPDKAEGVVEKRVDVPSEKKPTPALGVASTASFHFGRKVDSSVLGSLSTAPMANFSFSSGNVGVFGTDVTQAKPVSSFSPKVLESHPDGSAGEYKGGEEEESEEPPKAIVTEVKEEDAFYSKKCKLFYKKDNEFKEKGVGTLHLKPAGNQKTQLLVRADTNLGNILLNVLVPPNMPCSRTGKNNVLIVCVPNPPISEKHAAIPVTMLIRVKTTEDADELHKILLEKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4Q0</accession>
    <name>A0A5F8G4Q0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ANO4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4Q0"/>
    <dbReference type="Ensembl" id="ENSMODT00000057236.1">
        <property type="protein sequence ID" value="ENSMODP00000042411.1"/>
        <property type="gene ID" value="ENSMODG00000004966.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158600"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004966">
        <property type="expression patterns" value="Expressed in spinal cord and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF28">
        <property type="entry name" value="ANOCTAMIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="690"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="955"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="12">
        <location>
            <begin position="314"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="11">
        <location>
            <begin position="527"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1107"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1143" mass="130866" checksum="F3CD15B79275595C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4Q1</accession>
    <name>A0A5F8G4Q1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Obscurin like cytoskeletal adaptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">OBSL1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4Q1"/>
    <dbReference type="Ensembl" id="ENSMODT00000068107.1">
        <property type="protein sequence ID" value="ENSMODP00000042453.1"/>
        <property type="gene ID" value="ENSMODG00000015072.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156702"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015072">
        <property type="expression patterns" value="Expressed in ovary and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000241">
        <property type="entry name" value="obscurin-like protein 1 isoform X2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000608">
        <property type="entry name" value="obscurin-like protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000623">
        <property type="entry name" value="obscurin-like protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000464">
        <property type="entry name" value="Putative obscurin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052385">
        <property type="entry name" value="Obscurin/Obscurin-like_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35971:SF6">
        <property type="entry name" value="OBSCURIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35971">
        <property type="entry name" value="SI:DKEY-31G6.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="107"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="303"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="394"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="485"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="574" mass="62479" checksum="A47D0A2146A68421" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4Q2</accession>
    <name>A0A5F8G4Q2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Vav guanine nucleotide exchange factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">VAV3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4Q2"/>
    <dbReference type="Ensembl" id="ENSMODT00000088186.1">
        <property type="protein sequence ID" value="ENSMODP00000042432.1"/>
        <property type="gene ID" value="ENSMODG00000002796.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155252"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002796">
        <property type="expression patterns" value="Expressed in uterine wall and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20869">
        <property type="entry name" value="C1_VAV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21264">
        <property type="entry name" value="CH_VAV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01223">
        <property type="entry name" value="PH_Vav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10407">
        <property type="entry name" value="SH2_Vav3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11978">
        <property type="entry name" value="SH3_VAV3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000015">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000019">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000050">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000024">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000039">
        <property type="entry name" value="Vav guanine nucleotide exchange factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022613">
        <property type="entry name" value="CH_CAMSAP_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037832">
        <property type="entry name" value="PH_Vav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035881">
        <property type="entry name" value="VAV3_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035734">
        <property type="entry name" value="VAV3_SH3_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11971">
        <property type="entry name" value="CAMSAP_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="16">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="15">
        <location>
            <begin position="192"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="368"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
        <location>
            <begin position="481"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="559"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="639"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="755"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="535"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="814" mass="94029" checksum="16F33A2DFEDA70A3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4Q7</accession>
    <name>A0A5F8G4Q7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nectin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Nectin cell adhesion molecule 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Poliovirus receptor-related protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NECTIN4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nectin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4Q7"/>
    <dbReference type="Ensembl" id="ENSMODT00000056973.1">
        <property type="protein sequence ID" value="ENSMODP00000042437.1"/>
        <property type="gene ID" value="ENSMODG00000005386.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157535"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005386">
        <property type="expression patterns" value="Expressed in placenta and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000560">
        <property type="entry name" value="Nectin cell adhesion molecule 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000627">
        <property type="entry name" value="Nectin cell adhesion molecule 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277:SF11">
        <property type="entry name" value="NECTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
        <property type="entry name" value="NECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="104"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="221"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="359"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="444" mass="48293" checksum="09EE2F334C986FFE" modified="2019-12-11" version="1">MDWGSDEAVREDQRDPETGSRPFLSKDKIRAGNICNSQDGLFQGSLGYVSPGQGRARQGKSQRECRGPGGFSVGGKVVGESRCIRPAIGPSFYLMSSLPFPPSPVVPPLPTLNLGPALEEGQGRTLAASCTAEGSPMPNVTWDTVVKGSSTRRFSSHPRSASVTSEFYLVPSRTMNGQPITCVVSHPGLPESKRITHTLQVAFLAEASVWGHEDPELWHVGREGVMLKCLSEGQPPPSYNWTRLDRPLPSGVRVDGGTLGFPPLTPEHSGTYVCHVSNEVSSRNSQVTVAVTAENEAPPVDVDVVSASMVAVGVIAGLLLCLLVVVVLLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHSEPRNQSEEPEGRSYSTLTTVREIETQTELLSPGSGRTDEEEDRDAGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4Q8</accession>
    <name>A0A5F8G4Q8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RER1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4Q8"/>
    <dbReference type="FunCoup" id="A0A5F8G4Q8">
        <property type="interactions" value="2138"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042424"/>
    <dbReference type="Ensembl" id="ENSMODT00000077006.1">
        <property type="protein sequence ID" value="ENSMODP00000042424.1"/>
        <property type="gene ID" value="ENSMODG00000008117.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047137"/>
    <dbReference type="InParanoid" id="A0A5F8G4Q8"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008117">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033130">
        <property type="term" value="F:acetylcholine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071340">
        <property type="term" value="P:skeletal muscle acetylcholine-gated channel clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="214" mass="24586" checksum="542CD9C54F0D4E56" modified="2019-12-11" version="1">MSEGDSVGDSVHGKPSVVFRFFTRLGQIYQSWLDKSTPYTAVRWVVTLGLSFIYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDEGPSLPTKQNEEFRPFIRRLPEFKFWHSATKGILVAMICTFFDAFNVPVFWPILVMYFVMLFCITMKRQIKVRHNEQTLDCAGKVDCLGALGRDASTIGLQFSVEWVAFHIPTIGQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4Q9</accession>
    <name>A0A5F8G4Q9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thyroglobulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TG</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Monomer. Homodimer (via ChEL region); occurs in the endoplasmic reticulum and is required for export to the Golgi apparatus. Homooligomer; disulfide-linked; stored in this form in the thyroid follicle lumen.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000083961.1">
        <property type="protein sequence ID" value="ENSMODP00000042430.1"/>
        <property type="gene ID" value="ENSMODG00000001154.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159300"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001154">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000047">
        <property type="entry name" value="Thyroglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000127">
        <property type="entry name" value="Thyroglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000011">
        <property type="entry name" value="Thyroglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000013">
        <property type="entry name" value="Thyroglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000016">
        <property type="entry name" value="Thyroglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052001">
        <property type="entry name" value="MHC-II_Gamma/Thyroglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14093">
        <property type="entry name" value="HLA CLASS II GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14093:SF19">
        <property type="entry name" value="THYROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0372">Hormone</keyword>
    <keyword evidence="7" id="KW-0405">Iodination</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0765">Sulfation</keyword>
    <keyword evidence="11" id="KW-0795">Thyroid hormone</keyword>
    <keyword evidence="5" id="KW-0893">Thyroid hormones biosynthesis</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023892591" description="Thyroglobulin" evidence="16">
        <location>
            <begin position="19"/>
            <end position="2722"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="92"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="160"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="297"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="599"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="653"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="721"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="997"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="1069"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="1144"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="1506"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="130"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1037"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1179"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1188"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2722" mass="301461" checksum="BA2D73962B0550BE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4R7</accession>
    <name>A0A5F8G4R7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="3">4.1.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA photolyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Photoreactivating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">POPC1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA).</text>
            <dbReference type="EC" id="4.1.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4R7"/>
    <dbReference type="Ensembl" id="ENSMODT00000057126.1">
        <property type="protein sequence ID" value="ENSMODP00000042434.1"/>
        <property type="gene ID" value="ENSMODG00000018409.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010302"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018409">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009650">
        <property type="term" value="P:UV protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000002">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.80:FF:000004">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000110">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008148">
        <property type="entry name" value="DNA_photolyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032673">
        <property type="entry name" value="DNA_photolyase_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052219">
        <property type="entry name" value="Photolyase_Class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00591">
        <property type="entry name" value="phr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211:SF0">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTO-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01083">
        <property type="entry name" value="DNA_PHOTOLYASES_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="17">
        <location>
            <begin position="98"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="514" mass="59445" checksum="B5EF3CFCD2FD0A36" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G508</accession>
    <name>A0A5F8G508_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC73</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G508"/>
    <dbReference type="Ensembl" id="ENSMODT00000061006.1">
        <property type="protein sequence ID" value="ENSMODP00000042506.1"/>
        <property type="gene ID" value="ENSMODG00000009690.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013482"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009690">
        <property type="expression patterns" value="Expressed in blood and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031650">
        <property type="entry name" value="CCDC73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28660">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28660:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15818">
        <property type="entry name" value="CCDC73"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="289"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1071" mass="123475" checksum="49E790970A63B391" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G510</accession>
    <name>A0A5F8G510_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleckstrin homology and RhoGEF domain containing G4B</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000085823.1">
        <property type="protein sequence ID" value="ENSMODP00000042537.1"/>
        <property type="gene ID" value="ENSMODG00000025606.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162507"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025606">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13242">
        <property type="entry name" value="PH_puratrophin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052231">
        <property type="entry name" value="Rho_GEF_signaling-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845:SF1">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY AND RHOGEF DOMAIN CONTAINING G4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1534"/>
            <end position="1547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1608" mass="182879" checksum="F340B0DA0C49DCA4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G512</accession>
    <name>A0A5F8G512_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>nitrate(in) = nitrate(out)</text>
            <dbReference type="Rhea" id="RHEA:34923"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G512"/>
    <dbReference type="Ensembl" id="ENSMODT00000064435.1">
        <property type="protein sequence ID" value="ENSMODP00000042529.1"/>
        <property type="gene ID" value="ENSMODG00000003369.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164106"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003369">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03683">
        <property type="entry name" value="ClC_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000012">
        <property type="entry name" value="Chloride channel K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF3">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-KB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0129">CBS domain</keyword>
    <keyword evidence="10 16" id="KW-0868">Chloride</keyword>
    <keyword evidence="9" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="17">
        <location>
            <begin position="509"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="639" mass="70997" checksum="FE58BA8A937BD65A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G517</accession>
    <name>A0A5F8G517_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PDZ and LIM domain 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PDLIM5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007495784.1">
        <property type="nucleotide sequence ID" value="XM_007495722.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G517"/>
    <dbReference type="Ensembl" id="ENSMODT00000069012.1">
        <property type="protein sequence ID" value="ENSMODP00000042534.1"/>
        <property type="gene ID" value="ENSMODG00000019264.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100016411"/>
    <dbReference type="CTD" id="10611"/>
    <dbReference type="GeneTree" id="ENSGT00940000155292"/>
    <dbReference type="OrthoDB" id="5911912at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019264">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09453">
        <property type="entry name" value="LIM1_ENH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06753">
        <property type="entry name" value="PDZ_PDLIM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000019">
        <property type="entry name" value="LIM domain binding 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000010">
        <property type="entry name" value="PDZ and LIM domain protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000014">
        <property type="entry name" value="PDZ and LIM domain protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000020">
        <property type="entry name" value="PDZ and LIM domain protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF32">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="288"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="347"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="407"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="466" mass="51291" checksum="D007CAB66682EA73" modified="2019-12-11" version="1">MSNYNVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKASQAHVRIGDVVLSIDGISAQGMTHLEAQNKIKACTGSLNMTLQRASSTPKPEPISVQKNTQVKKTTPPKRPPRKHIVERNTEFYHIPTHSDASKKRLIEDTEDWHPRTGTTQSRSFRILAQITGTEHLKESDTDNTKKTNNIQDPIQPAASTVTTARNVPQSPESPVASRPGVASLTTAAAFKPAGSTNVIKSPNWQRQNPTAPSTGRISNNITPSGATAPTSPAQPQLNEQDTLVQRAEHIPAGKRTPMCAQCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVINALKQTWHVSCFVCVACNKPIRNNVFHLEDGDPYCETDYYALFGTICHGCEFPIEAGDLFLEALGHTWHDTCFVCSVCSDSLEGQTFFSKKDKPLCKKHAHSLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G518</accession>
    <name>A0A5F8G518_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenylate kinase 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G518"/>
    <dbReference type="Ensembl" id="ENSMODT00000080580.1">
        <property type="protein sequence ID" value="ENSMODP00000042516.1"/>
        <property type="gene ID" value="ENSMODG00000001217.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154568"/>
    <dbReference type="OMA" id="LENRCGQ"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001217">
        <property type="expression patterns" value="Expressed in kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="7">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="276" mass="30748" checksum="8B1311DC3C38AA8D" modified="2019-12-11" version="1">MGTGARRMPGRAEALGPEMCQEARLGWGCRGSRGTRSGWAPASAPIRGGVLPSRPPRRRSPLKGQASRGGACGQARQPREPQVHFELGEGGPIFQTHFPGERELGVLAKQYIDQGLLIPDHVITRLMVSELESRRVQPWLLDGFPRTLTQAEALDKICEPDLVISLNIPFETLKDRLSRRWIHLPSGRVYNLEFNPPQVQGVDDITGEPLIQQEADKPESVAARLRQYKEVAKPVIELYKHRGILHSFSGTETNKIWPYVYSLFSNKMASIGSKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G520</accession>
    <name>A0A5F8G520_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UGT2A1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G520"/>
    <dbReference type="Ensembl" id="ENSMODT00000084225.1">
        <property type="protein sequence ID" value="ENSMODP00000042540.1"/>
        <property type="gene ID" value="ENSMODG00000020753.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100010818"/>
    <dbReference type="GeneTree" id="ENSGT00940000161344"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020753">
        <property type="expression patterns" value="Expressed in liver and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000001">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000081">
        <property type="entry name" value="UDP-glucuronosyltransferase 2A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF140">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE 2A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023975674" description="UDP-glucuronosyltransferase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="530" mass="60573" checksum="91B9D44487FF6D03" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G521</accession>
    <name>A0A5F8G521_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adducin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ADD3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G521"/>
    <dbReference type="Ensembl" id="ENSMODT00000077308.1">
        <property type="protein sequence ID" value="ENSMODP00000042588.1"/>
        <property type="gene ID" value="ENSMODG00000010623.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155257"/>
    <dbReference type="OrthoDB" id="5920083at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010623">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18930">
        <property type="entry name" value="bHLHzip_MXI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000014">
        <property type="entry name" value="Max dimerization protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF13">
        <property type="entry name" value="MAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="109"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="228" mass="26088" checksum="FAB3C84CE6D2C49C" modified="2019-12-11" version="1">MERVRMINVQRLLEAAEFLERRERECEHGYASAFPSVPSPRMQHSKPPRRLSRAQKHNSGSSNTSTANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKRRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLQSIGSDEGYSSASVKLSFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G522</accession>
    <name>A0A5F8G522_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 3 open reading frame, human C22orf31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C3H22orf31</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_056677529.1">
        <property type="nucleotide sequence ID" value="XM_056821551.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056677530.1">
        <property type="nucleotide sequence ID" value="XM_056821552.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056677531.1">
        <property type="nucleotide sequence ID" value="XM_056821553.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056677532.1">
        <property type="nucleotide sequence ID" value="XM_056821554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G522"/>
    <dbReference type="Ensembl" id="ENSMODT00000085006.1">
        <property type="protein sequence ID" value="ENSMODP00000042552.1"/>
        <property type="gene ID" value="ENSMODG00000008597.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100030640"/>
    <dbReference type="CTD" id="100030640"/>
    <dbReference type="GeneTree" id="ENSGT00390000012489"/>
    <dbReference type="OMA" id="CCPAPCK"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008597">
        <property type="expression patterns" value="Expressed in testis and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028970">
        <property type="entry name" value="DUF4662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15578:SF0">
        <property type="entry name" value="CHROMOSOME 22 OPEN READING FRAME 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15578">
        <property type="entry name" value="CHROMOSOME 8 C22ORF31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15578">
        <property type="entry name" value="DUF4662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="299" mass="32062" checksum="DEAFF91F5AE5617E" modified="2019-12-11" version="1">MRRNSGIPTYGLRQSILVNKRLQDCYVDTPTLTNIWTSKTYANPSVASKGGLTSSWEVVKNPLVSSSFSLVKLVLRRQLKDKCCPIPPKLGAEGKARKIPKIKTKGTGPVRADPGDRDTEAVPDKDKSPSGKPSGTSDLMRSTGPDSESEESQKEEKEAAVGEDLQEGAVTQIPLGKSEGPVGETQVDLPLGNRGEPPQDTLIIHGLSAEQYTALYHSVVEPMLWNTSGTPKRYSLELGKVIKRKLWEALCSQATAPSPEGAGSGGVANNPGPPGKRPGPKPDREAGEQPAVPKWPKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G525</accession>
    <name>A0A5F8G525_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ecotropic viral integration site 5 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EVI5L</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G525"/>
    <dbReference type="Ensembl" id="ENSMODT00000053458.1">
        <property type="protein sequence ID" value="ENSMODP00000042521.1"/>
        <property type="gene ID" value="ENSMODG00000014976.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153846"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014976">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000002">
        <property type="entry name" value="Ecotropic viral integration site 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000002">
        <property type="entry name" value="Ecotropic viral integration site 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000003">
        <property type="entry name" value="Ecotropic viral integration site 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF12">
        <property type="entry name" value="ECOTROPIC VIRAL INTEGRATION SITE 5 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="126"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="777"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="371"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="629"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="801"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="826" mass="94631" checksum="42FB3AB35DAF4789" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G527</accession>
    <name>A0A5F8G527_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2 10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 10"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G527"/>
    <dbReference type="Ensembl" id="ENSMODT00000053231.1">
        <property type="protein sequence ID" value="ENSMODP00000042550.1"/>
        <property type="gene ID" value="ENSMODG00000006478.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008060"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006478">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000031">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001747">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="repeat" description="PPR" evidence="9">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="12">
        <location>
            <begin position="403"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1196" mass="135225" checksum="27E89DB7F2B1D071" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G529</accession>
    <name>A0A5F8G529_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA binding protein fox-1 homolog 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Fox-1 homolog B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RNA-binding motif protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RNA-binding protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RBFOX2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G529"/>
    <dbReference type="Ensembl" id="ENSMODT00000081376.1">
        <property type="protein sequence ID" value="ENSMODP00000042544.1"/>
        <property type="gene ID" value="ENSMODG00000001122.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157534"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001122">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12407">
        <property type="entry name" value="RRM_FOX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000375">
        <property type="entry name" value="RNA binding fox-1 homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025670">
        <property type="entry name" value="Fox-1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034237">
        <property type="entry name" value="FOX1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047131">
        <property type="entry name" value="RBFOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597">
        <property type="entry name" value="ATAXIN 2-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597:SF31">
        <property type="entry name" value="RNA BINDING PROTEIN FOX-1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12414">
        <property type="entry name" value="Fox-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="217"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="473" mass="49953" checksum="7B476870F123A084" modified="2019-12-11" version="1">MKRVFFNKIFSTPVRPAQSGPSRGIKRVFELEPPPPPPPPPPPLPAGPGPADPGPGKRLRTDEGAEGAGAPAQARPNEGAAAVGAGAGAGAGGGALQNESLTPGYHGFPARDNQGNQEPTATPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGGTQTHGEQSTNTASTQNGALTQTEGGAQTDGQQSQTQSSENTESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVDMQLTDMHSLLQRQQPQPLPPPQPLTATVMAGFIQQTPTMPLPLPLATELALWRVYTEVATADLPPTEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G531</accession>
    <name>A0A5F8G531_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protrudin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Zinc finger FYVE domain-containing protein 27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ZFYVE27</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Growth cone membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056657306.1">
        <property type="nucleotide sequence ID" value="XM_056801328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G531"/>
    <dbReference type="Ensembl" id="ENSMODT00000069158.1">
        <property type="protein sequence ID" value="ENSMODP00000042562.1"/>
        <property type="gene ID" value="ENSMODG00000003907.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100016126"/>
    <dbReference type="CTD" id="118813"/>
    <dbReference type="GeneTree" id="ENSGT00390000013298"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003907">
        <property type="expression patterns" value="Expressed in spinal cord and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071787">
        <property type="term" value="P:endoplasmic reticulum tubular network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042405">
        <property type="entry name" value="Protrudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14543">
        <property type="entry name" value="PROTRUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14543:SF1">
        <property type="entry name" value="PROTRUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="19">
        <location>
            <begin position="319"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="397" mass="44744" checksum="D5E1E351A1F74A16" modified="2019-12-11" version="1">MPEAQPDSPPAPPKPPVLDLFNLVLFYKRLVVYLEPLKDAFDGILYLLRWQTPVCSLLTCLGLNFLFLTLNEGAWYSVGALLISVPALLGYLQEVFRTRLSETELIRRKYHSVRQEDLQKVRLSRPEAVAEVKTFLIQLENFLNRLCNSCEAVYRVLYWENPVVSSQFYGLLLGSIFVLYLLPLCWILALLNSTLFLGNVEFYRVVAECRATLQQRMNPQLPGNTEDCLESDSGGRGVLLDCSSTPTPTEDLTPGSVEEAEEAEPDEEFKDAIEEDEEGSACSVEDDLALHDNGFMSKNEVIRSKVSRLTEKLRKRYPTNNFGNCASCSATFSVLKKRRSCSNCGNSFCSRCCSFKVLKSSMGATVCLSSPLLSIEKTRKTKPITDRCLVEKRWFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G534</accession>
    <name>A0A5F8G534_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RALBP1 associated Eps domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">REPS2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G534"/>
    <dbReference type="Ensembl" id="ENSMODT00000056013.1">
        <property type="protein sequence ID" value="ENSMODP00000042603.1"/>
        <property type="gene ID" value="ENSMODG00000017149.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158080"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017149">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF64">
        <property type="entry name" value="RALBP1-ASSOCIATED EPS DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="6">
        <location>
            <begin position="344"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="377"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="626"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="674" mass="76074" checksum="A8D8F4C15FB45401" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G535</accession>
    <name>A0A5F8G535_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease 3</fullName>
            <ecNumber evidence="7">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Ribonuclease III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24 25">protein Drosha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">DROSHA</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="23">Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8. The microprocessor complex is a heterotrimer; each of the two DROSHA RNase III domains binds one DGCR8 (via C-terminal region). Interacts with SP1 and SNIP1. Interacts with SRRT/ARS2. Interacts with CPSF3 and ISY1; this interaction is in an RNA dependent manner. Interacts with PUS10; interaction promotes pri-miRNAs processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="7"/>
    <dbReference type="Ensembl" id="ENSMODT00000056861.1">
        <property type="protein sequence ID" value="ENSMODP00000042549.1"/>
        <property type="gene ID" value="ENSMODG00000004807.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111052"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004807">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070878">
        <property type="term" value="F:primary miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19877">
        <property type="entry name" value="DSRM_RNAse_III_meta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000002">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000003">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000012">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058938">
        <property type="entry name" value="Helical_CED_Drosha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044442">
        <property type="entry name" value="RNAse_III_DSRM__animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26050">
        <property type="entry name" value="Helical_CED_Drosha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="18 26" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="29">
        <location>
            <begin position="869"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="29">
        <location>
            <begin position="1100"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="28">
        <location>
            <begin position="1253"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="113"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="416"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1351"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="27">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="27">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="27">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="206"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="326"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="27">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00055411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00063453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00078955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1379" mass="160013" checksum="4FB5497D55B3D0E2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVR8</accession>
    <name>A0A5F8GVR8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphodiesterase</fullName>
            <ecNumber evidence="12">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PDE8B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVR8"/>
    <dbReference type="Ensembl" id="ENSMODT00000067533.1">
        <property type="protein sequence ID" value="ENSMODP00000051743.1"/>
        <property type="gene ID" value="ENSMODG00000019740.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157817"/>
    <dbReference type="UniPathway" id="UPA00762">
        <property type="reaction ID" value="UER00747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019740">
        <property type="expression patterns" value="Expressed in endometrium and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000002">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000023">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057304">
        <property type="entry name" value="PDE8-like_REC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08629">
        <property type="entry name" value="PDE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23198">
        <property type="entry name" value="PDE8A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="263"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="15">
        <location>
            <begin position="465"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="541"/>
            <end position="545"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="757"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="809" mass="90818" checksum="82EEC7BD0328D45B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVS0</accession>
    <name>A0A5F8GVS0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100023173</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVS0"/>
    <dbReference type="Ensembl" id="ENSMODT00000054390.1">
        <property type="protein sequence ID" value="ENSMODP00000051640.1"/>
        <property type="gene ID" value="ENSMODG00000005361.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155736"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005361">
        <property type="expression patterns" value="Expressed in liver and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000299">
        <property type="entry name" value="Cytochrome P450 2C9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF400">
        <property type="entry name" value="CYTOCHROME P450 2C9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="447" mass="50736" checksum="7096FF1EF647D47C" modified="2019-12-11" version="1">MDPSVVTALGLIFCVSCLLLISAWRKGFGKGKLPPGPTPLPIIGNLLQLDTKNINKSFCELAKTYGSVFTLYLGSERAVVLHGQKAVKEALIGNGDAFAGRGSFPISETINKGLGLLFSNGERWKQIRRFSLMTLRNFGMGKRSIEERVQEEAKRLVEALKNTNGLPCDPTFIFGCAPCNVICSVVFQKHFEYQDKKFLTLMEYLNENLQILSSPWIQVYNLFPSLIHHLPGIHHKVIKNFRALNDFVLERVKEHQETVDPNDPRDFIDCFLMKMEQEKQNPKSEFIIENLVSTTIDLFGAGTETTSTTLRYGFLLLLKHPQIVDKIREEMDQVIGQNRSPCMKDRSSMPYTDAVIHEIQRYIDLVPTSLPHAVTQDVKFRQYLIPKGTTIIPLLTSVLYDNEEFPNPEQFDPGHFLDESGNFKKSDYFVPFSIGKMFLKNFVSVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVS1</accession>
    <name>A0A5F8GVS1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">STE20-related kinase adapter protein alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">STE20-related adapter protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">STRADA</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVS1"/>
    <dbReference type="Ensembl" id="ENSMODT00000070771.1">
        <property type="protein sequence ID" value="ENSMODP00000051748.1"/>
        <property type="gene ID" value="ENSMODG00000009817.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158827"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009817">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000130">
        <property type="entry name" value="STE20-related kinase adapter protein alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000213">
        <property type="entry name" value="STE20-related kinase adapter protein alpha isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF20">
        <property type="entry name" value="STE20-RELATED KINASE ADAPTER PROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="69"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="404" mass="44989" checksum="A20C7EF42CCB4722" modified="2019-12-11" version="1">MSFLVSKPERIRRWVSEKFIVEGLRDLELFGEQPPGDARRKTNESSSESIASSPKQDTMSSFLPEGGCYELLTVIGKGFEELMTVNLARYKPTGEHVTIRRINLEACTNEMVTFLQGELHVSKLFNHPNIVPYRATFVADNELWVVTSFMAYGSAKDLICTQFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISADGKVYLSGLRSSLSMISHGQRQRVVHDFPKYSIKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTTTIPAEELTMNTSRSGANSGLNEGLAASTTRNSNGDSPPHPYHRTFSPHFHHFVEQCLQRSPDFRSSDVPQRPFLNCSALSPPSPTLKAANPRTPVASLAWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVS2</accession>
    <name>A0A5F8GVS2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SMC5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Forms a heterodimer with smc6. Component of the SMC5-SMC6 complex which consists at least of smc5, smc6, nsmce2, nsmce1 and nsmce4a.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVS2"/>
    <dbReference type="Ensembl" id="ENSMODT00000064272.1">
        <property type="protein sequence ID" value="ENSMODP00000051459.1"/>
        <property type="gene ID" value="ENSMODG00000002801.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074816"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002801">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000793">
        <property type="entry name" value="Structural maintenance of chromosomes protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="160"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="671"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="761"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="977" mass="115160" checksum="5D64BB03858FE8BC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVS3</accession>
    <name>A0A5F8GVS3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Calsyntenin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">CLSTN1</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.</text>
    </comment>
    <comment type="function">
        <text evidence="21">In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP.</text>
    </comment>
    <comment type="function">
        <text evidence="22">Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane. Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="24">Interacts with APBB1; this interaction stabilizes AlcICD metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Interacts with PSEN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calsyntenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVS3"/>
    <dbReference type="Ensembl" id="ENSMODT00000088080.1">
        <property type="protein sequence ID" value="ENSMODP00000051617.1"/>
        <property type="gene ID" value="ENSMODG00000002944.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183086"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002944">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000036">
        <property type="entry name" value="Calsyntenin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000025">
        <property type="entry name" value="Calsyntenin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000062">
        <property type="entry name" value="Calsyntenin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045588">
        <property type="entry name" value="CLSTN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139">
        <property type="entry name" value="CALSYNTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139:SF4">
        <property type="entry name" value="CALSYNTENIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19699">
        <property type="entry name" value="CLSTN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 26" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 28" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="29">
        <location>
            <begin position="55"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="29">
        <location>
            <begin position="172"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1003"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="27">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="1029"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00057612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00058538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00063026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00065044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00069678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1045" mass="116339" checksum="7BBE0584861D503C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVS7</accession>
    <name>A0A5F8GVS7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AFG1-like ATPase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lactation elevated protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AFG1L</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Found in several complexes of 140-500 kDa. Interacts with YME1L1. Interacts with COX4I1. Interacts with COX5A. Interacts with TP53; mediates mitochondrial translocation of TP53 in response to genotoxic stress such as mitomycin C treatment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007484467.1">
        <property type="nucleotide sequence ID" value="XM_007484405.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVS7"/>
    <dbReference type="Ensembl" id="ENSMODT00000073900.1">
        <property type="protein sequence ID" value="ENSMODP00000051622.1"/>
        <property type="gene ID" value="ENSMODG00000017996.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021671"/>
    <dbReference type="CTD" id="246269"/>
    <dbReference type="GeneTree" id="ENSGT00390000013227"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017996">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000735">
        <property type="entry name" value="Lactation elevated 1 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="438" mass="49374" checksum="EB6FD0191C5450BA" modified="2019-12-11" version="1">MAASLSPWVTVRPLVQTWVRGRCTWWGARAAAAAAVGSAPATVPGRPPRKAYMVQSTESVTANSSTDGFSKALAGCNGPLEHYDFLIKANELKEDEHQRRVIQSLQELQKNLKGYHIGSKGLFSKLFTKRKPPKGLYVYGDVGTGKTMVMDMFYAYTEVERKKRVHFHGFMLDVHKRIHRLKQSLPKRKPGLMAKSYDPIAPIAEEISEEACLLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKKYCNTVQLDSGIDYRKRALPAAGKLYYLTSEADVEAVMDKLFDELAQKQNDLTRPRILKVQGRELRLNKACGTIADCTFEELCDKVRIICSASSPLSSLFLHQHHDSESEQSRILMDDLGLSQGSAESLSMFTGEEEIFAFHRTISRLTEMQTEQYWNDGDRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVT0</accession>
    <name>A0A5F8GVT0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Metastasis associated 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MTA1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the metastasis-associated protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007473391.1">
        <property type="nucleotide sequence ID" value="XM_007473329.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVT0"/>
    <dbReference type="Ensembl" id="ENSMODT00000085962.1">
        <property type="protein sequence ID" value="ENSMODP00000051627.1"/>
        <property type="gene ID" value="ENSMODG00000014663.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100014351"/>
    <dbReference type="CTD" id="9112"/>
    <dbReference type="GeneTree" id="ENSGT01030000234573"/>
    <dbReference type="OrthoDB" id="2193595at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014663">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04709">
        <property type="entry name" value="BAH_MTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000001">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.50:FF:000001">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035170">
        <property type="entry name" value="MTA1_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF5">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN MTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17226">
        <property type="entry name" value="MTA_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="14">
        <location>
            <begin position="165"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="15">
        <location>
            <begin position="283"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="702" mass="79924" checksum="63B278E845BD83F1" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVT2</accession>
    <name>A0A5F8GVT2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVT2"/>
    <dbReference type="Ensembl" id="ENSMODT00000066078.1">
        <property type="protein sequence ID" value="ENSMODP00000051655.1"/>
        <property type="gene ID" value="ENSMODG00000041988.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000041988">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="111"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="198"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="287"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="374"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="463"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="550"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="638" mass="69682" checksum="5BE0D720CFE9A519" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVT3</accession>
    <name>A0A5F8GVT3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 236</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF236</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007487864.1">
        <property type="nucleotide sequence ID" value="XM_007487802.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000067904.1">
        <property type="protein sequence ID" value="ENSMODP00000051763.1"/>
        <property type="gene ID" value="ENSMODG00000012304.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022366"/>
    <dbReference type="CTD" id="7776"/>
    <dbReference type="GeneTree" id="ENSGT00940000156787"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012304">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000573">
        <property type="entry name" value="Putative zinc finger protein 236"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000301">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000376">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000481">
        <property type="entry name" value="zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001012">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001071">
        <property type="entry name" value="zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001535">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002098">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002170">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002376">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002815">
        <property type="entry name" value="Zinc finger protein 236 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000308">
        <property type="entry name" value="zinc finger protein 236 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000226">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000385">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001017">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002389">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051643">
        <property type="entry name" value="Transcr_Reg_ZincFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396:SF21">
        <property type="entry name" value="ZINC FINGER PROTEIN 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="538"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="938"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="966"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="994"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1138"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1166"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1194"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1681"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1710"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1746"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1774"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1802"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="376"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1870" mass="207556" checksum="CE0CF9F238AD3F04" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVT5</accession>
    <name>A0A5F8GVT5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTPRF interacting protein alpha 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PPFIA1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVT5"/>
    <dbReference type="Ensembl" id="ENSMODT00000075069.1">
        <property type="protein sequence ID" value="ENSMODP00000051632.1"/>
        <property type="gene ID" value="ENSMODG00000019765.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244900"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019765">
        <property type="expression patterns" value="Expressed in placenta and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd09565">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09568">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000002">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000004">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037621">
        <property type="entry name" value="LIP-1_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037622">
        <property type="entry name" value="LIP-1_SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF15">
        <property type="entry name" value="LIPRIN-ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="241" mass="28322" checksum="E65771B079716099" modified="2019-12-11" version="1">MEVLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELEKRREESQNELKEVLVWSNDRMIRWILSIGLKEYANNLVESGVHGALVALDETFDFNALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFEEDDDKSFRRAPSWRKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDVYPHYFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVT9</accession>
    <name>A0A5F8GVT9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TAOK1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVT9"/>
    <dbReference type="Ensembl" id="ENSMODT00000083316.1">
        <property type="protein sequence ID" value="ENSMODP00000051479.1"/>
        <property type="gene ID" value="ENSMODG00000019329.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155796"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019329">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000030">
        <property type="entry name" value="Serine/threonine-protein kinase TAO2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TAO2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051234">
        <property type="entry name" value="TAO_STE20_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167:SF8">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="28"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="324"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="761"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="463"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="681"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="825"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="851" mass="97253" checksum="195A534A6A634B0D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVU0</accession>
    <name>A0A5F8GVU0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Chromodomain helicase DNA binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CHD2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000079128.1">
        <property type="protein sequence ID" value="ENSMODP00000051637.1"/>
        <property type="gene ID" value="ENSMODG00000013158.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155888"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013158">
        <property type="expression patterns" value="Expressed in blood and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18666">
        <property type="entry name" value="CD1_tandem_CHD1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18661">
        <property type="entry name" value="CD2_tandem_CHD1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18054">
        <property type="entry name" value="DEXHc_CHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000106">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000008">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000014">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000007">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040793">
        <property type="entry name" value="CDH1_2_SANT_HL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF19">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18375">
        <property type="entry name" value="CDH1_2_SANT_HL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="269"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="386"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="503"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="802"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1074"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1345"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1563"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1681"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1355"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1404"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1573"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1592"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1681"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1706"/>
            <end position="1727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1727" mass="199656" checksum="248E45F461037010" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVU1</accession>
    <name>A0A5F8GVU1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-(1,6)-fucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">GDP-fucose--glycoprotein fucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glycoprotein 6-alpha-L-fucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">FUT8</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP-beta-L-fucose = an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12985"/>
            <dbReference type="Rhea" id="RHEA-COMP:13526"/>
            <dbReference type="Rhea" id="RHEA-COMP:13532"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:60651"/>
            <dbReference type="ChEBI" id="CHEBI:137207"/>
            <dbReference type="EC" id="2.4.1.68"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the glycosyltransferase 23 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.68" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVU1"/>
    <dbReference type="FunCoup" id="A0A5F8GVU1">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051281"/>
    <dbReference type="Ensembl" id="ENSMODT00000058877.1">
        <property type="protein sequence ID" value="ENSMODP00000051281.1"/>
        <property type="gene ID" value="ENSMODG00000009731.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063737"/>
    <dbReference type="InParanoid" id="A0A5F8GVU1"/>
    <dbReference type="OMA" id="NPPVFFV"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009731">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008424">
        <property type="term" value="F:glycoprotein 6-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010761">
        <property type="term" value="P:fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046368">
        <property type="term" value="P:GDP-L-fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043112">
        <property type="term" value="P:receptor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900407">
        <property type="term" value="P:regulation of cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007585">
        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11300">
        <property type="entry name" value="Fut8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11792">
        <property type="entry name" value="SH3_Fut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1060:FF:000003">
        <property type="entry name" value="Alpha-(1,6)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000070">
        <property type="entry name" value="Alpha-(1,6)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000001">
        <property type="entry name" value="Alpha-(1,6)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045573">
        <property type="entry name" value="Fut8_N_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035653">
        <property type="entry name" value="Fut8_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027350">
        <property type="entry name" value="GT23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19745">
        <property type="entry name" value="FUT8_N_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51659">
        <property type="entry name" value="GT23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 21" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="13" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="GT23" evidence="25">
        <location>
            <begin position="286"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="24">
        <location>
            <begin position="582"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for donor substrate binding" evidence="21">
        <location>
            <begin position="445"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00093238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="655" mass="75572" checksum="D8D24FB9A1E2C71A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVU5</accession>
    <name>A0A5F8GVU5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family with sequence similarity 13 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM13B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVU5"/>
    <dbReference type="Ensembl" id="ENSMODT00000075593.1">
        <property type="protein sequence ID" value="ENSMODP00000051642.1"/>
        <property type="gene ID" value="ENSMODG00000012247.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183033"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012247">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039102">
        <property type="entry name" value="FAM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059029">
        <property type="entry name" value="FAM13A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904">
        <property type="entry name" value="FAM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904:SF16">
        <property type="entry name" value="PROTEIN FAM13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26116">
        <property type="entry name" value="FAM13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="797" mass="91211" checksum="43C612DBDD0513D9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVU6</accession>
    <name>A0A5F8GVU6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450 3A</fullName>
            <ecNumber evidence="15">1.14.14.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100010820</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.-" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVU6"/>
    <dbReference type="Ensembl" id="ENSMODT00000061535.1">
        <property type="protein sequence ID" value="ENSMODP00000051484.1"/>
        <property type="gene ID" value="ENSMODG00000047860.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182958"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000047860">
        <property type="expression patterns" value="Expressed in liver and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd20650">
        <property type="entry name" value="CYP3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000096">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008072">
        <property type="entry name" value="Cyt_P450_E_CYP3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF38">
        <property type="entry name" value="CYTOCHROME P450 3A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01689">
        <property type="entry name" value="EP450IICYP3A"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="490" mass="56121" checksum="AC520CC27D1E0E13" modified="2019-12-11" version="1">MGLCLIPVFSSLEKNLLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVLAIMDPETIKTVLVKECYSVFTNRRMFGPSGFLEKAISIAKDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEAEKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFPKEATDFLAKSIIKIKEERTKSTEKHRVDFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQEKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPEPEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQAELRNKKGNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVU7</accession>
    <name>A0A5F8GVU7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Scaffold attachment factor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SAFB</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVU7"/>
    <dbReference type="Ensembl" id="ENSMODT00000087651.1">
        <property type="protein sequence ID" value="ENSMODP00000051670.1"/>
        <property type="gene ID" value="ENSMODG00000001236.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155916"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001236">
        <property type="expression patterns" value="Expressed in hindlimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12679">
        <property type="entry name" value="RRM_SAFB1_SAFB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000197">
        <property type="entry name" value="Scaffold attachment factor B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000005">
        <property type="entry name" value="scaffold attachment factor B2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051738">
        <property type="entry name" value="SAF_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034781">
        <property type="entry name" value="SAFB1_2_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683:SF6">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SAP" evidence="16">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="409"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="227"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="479"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="697"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="750"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="479"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="584"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="750"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="817"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="846"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="859" mass="97473" checksum="2D23651D8794E709" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVU8</accession>
    <name>A0A5F8GVU8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Syntaxin-8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">STX8</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVU8"/>
    <dbReference type="Ensembl" id="ENSMODT00000062221.1">
        <property type="protein sequence ID" value="ENSMODP00000051291.1"/>
        <property type="gene ID" value="ENSMODG00000008471.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007779"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008471">
        <property type="expression patterns" value="Expressed in lung and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd15852">
        <property type="entry name" value="SNARE_Syntaxin8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000036">
        <property type="entry name" value="Putative Syntaxin-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041875">
        <property type="entry name" value="Syntaxin-8_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF124">
        <property type="entry name" value="SYNTAXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="221" mass="25235" checksum="15DB364B371DD8C1" modified="2019-12-11" version="1">MAPDPWLSTYDATCHIAQEIAEKIQQRNQCERNGESTTKLTVTIRALLQNLKEKITLLRELLLRAVSTHQITQLEGDRRQNLLDDLVTRERLLQASYKNDGTEPDLIRSSLMTKTANRVVSNPWFFEESEETRALGFDDLRQQQQKIIQEQDAGLDALSSIISRQKQMGQEIGNELDEQNEIIDDLANLVENTDERLYNQTRRVKMVDKKSTSCGAGLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW38</accession>
    <name>A0A5F8GW38_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bromodomain adjacent to zinc finger domain protein 1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BAZ1A</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WAL family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000075231.1">
        <property type="protein sequence ID" value="ENSMODP00000051589.1"/>
        <property type="gene ID" value="ENSMODG00000012946.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100010775"/>
    <dbReference type="CTD" id="11177"/>
    <dbReference type="GeneTree" id="ENSGT00940000158135"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012946">
        <property type="expression patterns" value="Expressed in blood and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05504">
        <property type="entry name" value="Bromo_Acf1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15627">
        <property type="entry name" value="PHD_BAZ1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000029">
        <property type="entry name" value="Bromodomain adjacent to zinc finger domain protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000300">
        <property type="entry name" value="Bromodomain adjacent to zinc finger domain protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037325">
        <property type="entry name" value="Acf1_Bromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047171">
        <property type="entry name" value="BAZ1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510:SF1">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="10 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WAC" evidence="23">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="22">
        <location>
            <begin position="423"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="1113"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="20">
        <location>
            <begin position="1415"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="640"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1167"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="311"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1178"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1226"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1241"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1256"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1321"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1332"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1355"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1524" mass="175898" checksum="74B0A0EA468C3F49" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW39</accession>
    <name>A0A5F8GW39_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periphilin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PPHLN1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW39"/>
    <dbReference type="Ensembl" id="ENSMODT00000075607.1">
        <property type="protein sequence ID" value="ENSMODP00000051707.1"/>
        <property type="gene ID" value="ENSMODG00000008885.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016228"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008885">
        <property type="expression patterns" value="Expressed in blood and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22896">
        <property type="entry name" value="periphilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057603">
        <property type="entry name" value="Periphilin-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028851">
        <property type="entry name" value="Pphln1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836">
        <property type="entry name" value="PERIPHILIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836:SF4">
        <property type="entry name" value="PERIPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25234">
        <property type="entry name" value="Periphilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Periphilin-1 C-terminal" evidence="2">
        <location>
            <begin position="286"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="382" mass="44060" checksum="03B8DF611019677D" modified="2019-12-11" version="1">MAYRRDDLWSDGRYEYDRLPRERLPPRSHAEDDYLRVVNIISKKPPLLDRPGEGGYSRYDYSLVDYQEYDEGRSFSHDRRSGTPHRGDEPSYRWTRDDHPISRQPDYRDTRDGFRRKGFYSSHYMRERSPHKRDTPFFRESPVNRKDSPHSRSGSSVSSRSYSPERSKTYSFHQSQHRKSVRAGACYKQQNEGEPGRGKERPSAQSLKTSRDTSPSSSTAAPSSKVLDKPSRLTEKELAEAANKWAAEKLEKTDENNLPEISDYDAGSSAPLYNDQAEEPETNATDSIELFEDNQVTSRSKAIASKTKEIEQVYRQDCETFGMVVKMLIDKDPSLEKSVQFALRQNLHEIVPGSFAKNIMKVSTCFLHLLKSLEDKMKGLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW41</accession>
    <name>A0A5F8GW41_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rap guanine nucleotide exchange factor 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exchange factor directly activated by cAMP 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Exchange protein directly activated by cAMP 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">cAMP-regulated guanine nucleotide exchange factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RAPGEF4</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056649987.1">
        <property type="nucleotide sequence ID" value="XM_056794009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW41"/>
    <dbReference type="Ensembl" id="ENSMODT00000069866.1">
        <property type="protein sequence ID" value="ENSMODP00000051873.1"/>
        <property type="gene ID" value="ENSMODG00000009089.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100025283"/>
    <dbReference type="CTD" id="11069"/>
    <dbReference type="GeneTree" id="ENSGT00940000156075"/>
    <dbReference type="OrthoDB" id="21144at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009089">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050796">
        <property type="term" value="P:regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04437">
        <property type="entry name" value="DEP_Epac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01765">
        <property type="entry name" value="FERM_F0_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1240:FF:000001">
        <property type="entry name" value="Rap guanine nucleotide exchange factor (GEF) 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000096">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000002">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.870.10:FF:000005">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000015">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000038">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF175">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0114">cAMP</keyword>
    <keyword evidence="5" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6 16" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DEP" evidence="20">
        <location>
            <begin position="45"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="185"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="21">
        <location>
            <begin position="325"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="18">
        <location>
            <begin position="601"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="840" mass="96199" checksum="8CF07CA8456E5408" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW42</accession>
    <name>A0A5F8GW42_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adiponectin receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ADIPOR1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW42"/>
    <dbReference type="Ensembl" id="ENSMODT00000073789.1">
        <property type="protein sequence ID" value="ENSMODP00000051775.1"/>
        <property type="gene ID" value="ENSMODG00000000876.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154563"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000876">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF40">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="172" mass="19362" checksum="E5A10C0CC6A2D852" modified="2019-12-11" version="1">MSSSKGSAVGPGNGAPASNRETDTVELAELGPLLIEKGKRMTPSSTKVEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEGRWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLATAHLPLHCLCPGHLCHHCSPVGPVCHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW43</accession>
    <name>A0A5F8GW43_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mastermind like domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MAMLD1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW43"/>
    <dbReference type="Ensembl" id="ENSMODT00000056346.1">
        <property type="protein sequence ID" value="ENSMODP00000051594.1"/>
        <property type="gene ID" value="ENSMODG00000005627.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111366"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005627">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026131">
        <property type="entry name" value="MAMLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15275">
        <property type="entry name" value="CG1 PROTEIN/F18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15275:SF0">
        <property type="entry name" value="MASTERMIND-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="955" mass="101991" checksum="95F698A2540D4F9C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW45</accession>
    <name>A0A5F8GW45_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 107 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM107B</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007504050.1">
        <property type="nucleotide sequence ID" value="XM_007503988.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW45"/>
    <dbReference type="Ensembl" id="ENSMODT00000087583.1">
        <property type="protein sequence ID" value="ENSMODP00000051391.1"/>
        <property type="gene ID" value="ENSMODG00000016919.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100014604"/>
    <dbReference type="KEGG" id="mdo:100014604"/>
    <dbReference type="CTD" id="83641"/>
    <dbReference type="GeneTree" id="ENSGT00390000011228"/>
    <dbReference type="OMA" id="DTMMSMS"/>
    <dbReference type="OrthoDB" id="5963205at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016919">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009533">
        <property type="entry name" value="FAM107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768">
        <property type="entry name" value="DOWN REGULATED IN RENAL CARCINOMA 1/TU3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768:SF1">
        <property type="entry name" value="PROTEIN FAM107B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06625">
        <property type="entry name" value="DUF1151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="168" mass="19640" checksum="426F808B4A4D6715" modified="2019-12-11" version="1">MGQHIPPGTTVTNSLVQDNIIEDPELKDSILIQKSIMAEPDYIEDDNPELIKPQKLINPVKISRNHQDLHRELLMNQKRGLAPQNKPELQRVMEKRKRDQVIKQQKEEEAQKKKSDLEIELLKRQQKLEQLELEKQKIQEEQENAPEFVKVKGNLRRTGQEVAEVQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW46</accession>
    <name>A0A5F8GW46_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome non-ATPase regulatory subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">26S proteasome regulatory subunit RPN8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PSMD7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD7, a base containing 6 ATPases and few additional components. Within the complex, PSMD7 interacts with subunit PSMD4 through their respective MPN domain. Interacts with TRIM5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056667427.1">
        <property type="nucleotide sequence ID" value="XM_056811449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW46"/>
    <dbReference type="Ensembl" id="ENSMODT00000055150.1">
        <property type="protein sequence ID" value="ENSMODP00000051780.1"/>
        <property type="gene ID" value="ENSMODG00000002631.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100020514"/>
    <dbReference type="CTD" id="5713"/>
    <dbReference type="GeneTree" id="ENSGT00950000183073"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002631">
        <property type="expression patterns" value="Expressed in forelimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000009">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="328" mass="37329" checksum="001D99425928BC4B" modified="2019-12-11" version="1">MTLGQSFIYRGAHACSSHPTRLLIRASVTIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKGLNSKLLDIRGYLEKVAMGKLPINHQIIYQLQDVFNLLPDVNLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKERKDDKEKDKDKEKGDAKKEEKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW47</accession>
    <name>A0A5F8GW47_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho guanine nucleotide exchange factor 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000060189.1">
        <property type="protein sequence ID" value="ENSMODP00000051599.1"/>
        <property type="gene ID" value="ENSMODG00000018631.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160622"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018631">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01224">
        <property type="entry name" value="PH_Collybistin_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11973">
        <property type="entry name" value="SH3_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000002">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000015">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="960"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1271"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="594"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1025"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1027"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1464" mass="163505" checksum="41BDD30A1B611D28" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW48</accession>
    <name>A0A5F8GW48_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin specific peptidase 53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">USP53</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW48"/>
    <dbReference type="Ensembl" id="ENSMODT00000062627.1">
        <property type="protein sequence ID" value="ENSMODP00000051878.1"/>
        <property type="gene ID" value="ENSMODG00000018951.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156337"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018951">
        <property type="expression patterns" value="Expressed in uterine wall and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052398">
        <property type="entry name" value="Ubiquitin_hydrolase_53/54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975:SF6">
        <property type="entry name" value="INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="30"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="736"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="835"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="900"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="919"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="938"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114847" checksum="65A28725E151A0C6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW51</accession>
    <name>A0A5F8GW51_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Corticotropin-releasing factor-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Corticotropin-releasing hormone-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CRHBP</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRF-binding protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW51"/>
    <dbReference type="Ensembl" id="ENSMODT00000070473.1">
        <property type="protein sequence ID" value="ENSMODP00000051604.1"/>
        <property type="gene ID" value="ENSMODG00000019745.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001362"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019745">
        <property type="expression patterns" value="Expressed in ovary and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051424">
        <property type="term" value="F:corticotropin-releasing hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008435">
        <property type="entry name" value="CRF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056178">
        <property type="entry name" value="CRF-BP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056177">
        <property type="entry name" value="CRF-BP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278:SF0">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23541">
        <property type="entry name" value="CRF-BP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05428">
        <property type="entry name" value="CRF-BP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023894345" description="Corticotropin-releasing factor-binding protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor binding protein N-terminal" evidence="11">
        <location>
            <begin position="52"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor binding protein C-terminal" evidence="12">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="251" mass="28457" checksum="76D3C88349A52E7E" modified="2019-12-11" version="1">MSPAFKLQCHFILIFLGALRGETRYLELREVAEADPLLLFNTDLKRELSEEQLYHRSLRCIDMLSIEGQFTFTAEQPQLQCAAFFIGEPEEVISIQYDLVSVDCQGGDFLKVFDGWILKGEKFPSSQDHPLPMSDRYIDFCESENIRTFSSSQNVAMIFFRIHEPGNGFTITVKKNPNLFPCNVISQTPNGRFTMVIPHQHRNCSFSIIYPVVIKISDLILGHLNGLQLKVSCLLLPKSILTVLSIIVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW52</accession>
    <name>A0A5F8GW52_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Far upstream element binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FUBP3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW52"/>
    <dbReference type="Ensembl" id="ENSMODT00000064355.1">
        <property type="protein sequence ID" value="ENSMODP00000051785.1"/>
        <property type="gene ID" value="ENSMODG00000012105.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156744"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012105">
        <property type="expression patterns" value="Expressed in forelimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22480">
        <property type="entry name" value="KH-I_FUBP3_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22489">
        <property type="entry name" value="KH-I_FUBP3_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000007">
        <property type="entry name" value="far upstream element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000010">
        <property type="entry name" value="far upstream element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="78"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="219"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="320"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="539" mass="57898" checksum="480A3D0C93C29D4C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW55</accession>
    <name>A0A5F8GW55_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RUN domain-containing protein 3B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RUNDC3B</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with RAP2A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUNDC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003342140.1">
        <property type="nucleotide sequence ID" value="XM_003342092.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW55"/>
    <dbReference type="Ensembl" id="ENSMODT00000064556.1">
        <property type="protein sequence ID" value="ENSMODP00000051790.1"/>
        <property type="gene ID" value="ENSMODG00000010272.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100020921"/>
    <dbReference type="CTD" id="154661"/>
    <dbReference type="GeneTree" id="ENSGT00940000159175"/>
    <dbReference type="OrthoDB" id="10029904at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010272">
        <property type="expression patterns" value="Expressed in spinal cord and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd17700">
        <property type="entry name" value="RUN_RUNDC3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047339">
        <property type="entry name" value="RUN_RUNDC3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047340">
        <property type="entry name" value="RUNDC3A_B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46251">
        <property type="entry name" value="RUN DOMAIN-CONTAINING 3 PROTEIN RUNDC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46251:SF1">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="6">
        <location>
            <begin position="58"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="457" mass="51043" checksum="70A68D95F3863AB9" modified="2019-12-11" version="1">MASLSLGGLSVNRGGGGSSSCKKSLNARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGNFPAVIDYTPYLKFTQSSDSISSDEEELRTLGSSGSESSTPENIGPPFIMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLAESVSQNKLLLQRIEDSDLTHKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTTHLTNQWPSPGALDVNAVALDTLLYRKHNKQWDDKSFQSLDQLSAEVSLSQTSLDPAHSQDGDGKQDMLNLLNEGKEDTPSLLGLCGSLTSVASYKSLTSLKSSDYLASPTTEMTSPGLTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW58</accession>
    <name>A0A5F8GW58_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Erythrocyte membrane protein band 4.1 like 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EPB41L4B</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW58"/>
    <dbReference type="Ensembl" id="ENSMODT00000085762.1">
        <property type="protein sequence ID" value="ENSMODP00000051893.1"/>
        <property type="gene ID" value="ENSMODG00000003302.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158331"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003302">
        <property type="expression patterns" value="Expressed in uterine wall and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13186">
        <property type="entry name" value="FERM_C_NBL4_NBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17204">
        <property type="entry name" value="FERM_F1_EPB41L4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000024">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1-like 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000003">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030698">
        <property type="entry name" value="EHM2_FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF18">
        <property type="entry name" value="BAND 4.1-LIKE PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="80"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="706"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="854" mass="95824" checksum="E42F5572684E9609" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW65</accession>
    <name>A0A5F8GW65_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">G protein-coupled receptor 161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GPR161</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW65"/>
    <dbReference type="Ensembl" id="ENSMODT00000057192.1">
        <property type="protein sequence ID" value="ENSMODP00000051742.1"/>
        <property type="gene ID" value="ENSMODG00000002870.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157829"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002870">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15214">
        <property type="entry name" value="7tmA_GPR161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000091">
        <property type="entry name" value="G-protein coupled receptor 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF10">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="47"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="501" mass="55863" checksum="73A24E3DDF558AC6" modified="2019-12-11" version="1">MLTMSINSSLSHGKELANVPGSEGEDGAVTITESIAIIIIAIFVCLGNSVIVFTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVATSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREIGYTAFWQIWCALLPFVVMVVCYGFIFRVARVKARKVHCGTVVIVEEDAQRNGRKNSNTSTSSSGSRRNTFQGVVYSANQCKALITILVVIGAFVVTWGPYMVVITSEALWGKNSVSPALETLATWLSFTSAICHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRPRTSRLFSISNRITDLGLSPHLTALMAGAQPLGHSSSTGDTGFSCSQDSGTDVMLLEDYSSDDNPSRCTCPPKRRSSVTFEDEVEQMKEAAKSSILHVKAEVHKSLDSCRALTKETFSFETISHLVFKGQCGELICKHQKKEREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW66</accession>
    <name>A0A5F8GW66_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TEF transcription factor, PAR bZIP family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TEF</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. PAR subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007506122.1">
        <property type="nucleotide sequence ID" value="XM_007506060.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW66"/>
    <dbReference type="Ensembl" id="ENSMODT00000067122.1">
        <property type="protein sequence ID" value="ENSMODP00000051805.1"/>
        <property type="gene ID" value="ENSMODG00000016547.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013000"/>
    <dbReference type="CTD" id="7008"/>
    <dbReference type="GeneTree" id="ENSGT00940000156578"/>
    <dbReference type="OrthoDB" id="9449278at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016547">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000007">
        <property type="entry name" value="hepatic leukemia factor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF24">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="400" mass="44082" checksum="ADC21054D581DC81" modified="2019-12-11" version="1">MNVLERWGSRGRGERLCAPAQWGLAAVAAAPLGAFGRDLQPRPTRATMSDSGGVEKKLPLEAEAGPGREVTTAERGPPDPFPLALKKLMENPPREARLDKEKEKEKLEEDEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLIQNALLPGIELEGKESTSSSTASPSSSSTMVFQPSETASSTESSVENERETPSPIDPSCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKSIVSKYETKYGPLSGLTRAASLWHLGMVPGFSCPHIPSDSRVCWPATCQIPSNVALKTFNKREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7R8</accession>
    <name>A0A5F8H7R8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Somatomedin B and thrombospondin type 1 domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SBSPON</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_056680084.1">
        <property type="nucleotide sequence ID" value="XM_056824106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7R8"/>
    <dbReference type="Ensembl" id="ENSMODT00000073051.1">
        <property type="protein sequence ID" value="ENSMODP00000055604.1"/>
        <property type="gene ID" value="ENSMODG00000007144.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100028330"/>
    <dbReference type="CTD" id="157869"/>
    <dbReference type="GeneTree" id="ENSGT00390000008325"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007144">
        <property type="expression patterns" value="Expressed in placenta and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056801">
        <property type="entry name" value="SBSPON_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF2">
        <property type="entry name" value="SOMATOMEDIN-B AND THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25031">
        <property type="entry name" value="SBSPON_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Spondin-like TSP1" evidence="4">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="SBSPON-like C-terminal" evidence="5">
        <location>
            <begin position="134"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="250" mass="28536" checksum="D84956FBA3257193" modified="2019-12-11" version="1">MLPFFLQEPNSYYQCSTFTLASLPEEKRKEFKNIRSLSRLSGKMKCSAEKTNNERSLARPCIVGEWSSWSSCTDQCKPATRVRRRYVQQEPQNGGEPCPHLEEKAGCLEYTTSHGQDCGHSYVPAFITTSAYNKERKRQVVSPQWSADTGDAGYCMEFKTESLTHYCAMENRPLTRWMQYLREGYTVCVDCQPPAMNTVNLRCSGDGLDSDGNQTLHWQAIGNPRCQGTWKKVRRVDHCSCPAVHSFIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7R9</accession>
    <name>A0A5F8H7R9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 4 regulatory subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PPP4R4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Putative regulatory subunit of serine/threonine-protein phosphatase 4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7R9"/>
    <dbReference type="Ensembl" id="ENSMODT00000076324.1">
        <property type="protein sequence ID" value="ENSMODP00000055251.1"/>
        <property type="gene ID" value="ENSMODG00000002367.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047895"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002367">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000097">
        <property type="entry name" value="Serine/threonine-protein phosphatase 4 regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039918">
        <property type="entry name" value="PPP4R4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21467">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4 PPP4R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21467:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="713"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="765"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="810" mass="93299" checksum="3F60D3AD8DAFB401" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7S2</accession>
    <name>A0A5F8H7S2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease 3'-5' domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">EXD1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7S2"/>
    <dbReference type="Ensembl" id="ENSMODT00000075376.1">
        <property type="protein sequence ID" value="ENSMODP00000055862.1"/>
        <property type="gene ID" value="ENSMODG00000000164.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003581"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000164">
        <property type="expression patterns" value="Expressed in ovary and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="489" mass="55039" checksum="47B522AA049EED38" modified="2019-12-11" version="1">MDPSSDYHFLNQILGRRVKITLVCGIFQGVLQHVDPSKIIVLKKVKNLETGRSVPGVKMFFGHEIVNVELLDDMEQGIGEKPPSVRDCLNTEGTRMDKVKEADQSINDSASSSLESHTITLLNDLKYSPSEEEDVMYTVVNQFQQKFGSAMLHIKKQSVLSVAAEGVNLCRHGKLCWLQVIHDCRWLSDCLSHQYGIVLSNVFDTQVADVLQFSMETGGFLPHCISTLQESLIRHLKMSPKCVSFLDDKQKMVQENPEIWFVRPLPPSLLKVLALETTYLLPLRLLLLDEMMSDLTTLVDAYLNTYREGSGDLLGGTEPSCMELPEELRQLMDFQRLRRERAMKDYKTNAEGLLVRSQLIYPKEKTVEEEGKPKSSRGSLPFEGAMLPKALDLGYLKPQQAQEDRSLQKQETKYDSKQVRIKHQHSSSSEEPETGDSAAKAGPSCFGLKGSKDVKGTRKEQTDTPKQTQSSLSLQEKIELLLMGGKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7S3</accession>
    <name>A0A5F8H7S3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">BRG1-associated factor 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SMARCE1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7S3"/>
    <dbReference type="Ensembl" id="ENSMODT00000070422.1">
        <property type="protein sequence ID" value="ENSMODP00000055256.1"/>
        <property type="gene ID" value="ENSMODG00000013191.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003628"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013191">
        <property type="expression patterns" value="Expressed in hindlimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21983">
        <property type="entry name" value="HMG-box_SMARCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000011">
        <property type="entry name" value="Putative SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46232">
        <property type="entry name" value="SMARCE1 REGULATOR OF CHROMATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46232:SF1">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="295"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="372" mass="41657" checksum="40E3AB3526D53F9B" modified="2019-12-11" version="1">MSKRPSYAPPPTPAPATQMPSTPGFVGYNPYSHLAYNNYRLGGNPGTNSRVTASSGITIPKPPKPPDKPLMPYMRYSRKVWDQVKASNPDLKLWEIGKIIGGMWRDLTDEEKQEYLNEYEAEKIEYNESMKAYHNSPAYLAYINAKSRAEAALEEESRQRQSRMEKGEPYMSIQPAEDPDDYDDGFSMKHTATARFQRNHRLISEILSESVVPDVRSVVTTARMQVLKRQVQSLMVHQRKLEAELLQIEERHQEKKRKFLESTDSFNNELKRLCSLKVEVDMEKIAAEIAQAEEQARKRQEEREKEAMEQAERSQSGTSVAAAAAAAAAAAAAAAAAATATTTTTATAEDDQTASKGDEKKEEESTPMETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7S4</accession>
    <name>A0A5F8H7S4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC1 domain family member 12</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7S4"/>
    <dbReference type="Ensembl" id="ENSMODT00000064248.1">
        <property type="protein sequence ID" value="ENSMODP00000056013.1"/>
        <property type="gene ID" value="ENSMODG00000005589.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100023353"/>
    <dbReference type="KEGG" id="mdo:100023353"/>
    <dbReference type="CTD" id="23232"/>
    <dbReference type="GeneTree" id="ENSGT00940000156410"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005589">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000008">
        <property type="entry name" value="Putative TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000005">
        <property type="entry name" value="TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000006">
        <property type="entry name" value="TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="509"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="439"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="805" mass="88147" checksum="6F2E4CA5D66C898A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7S7</accession>
    <name>A0A5F8H7S7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NADSYN1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7S7"/>
    <dbReference type="Ensembl" id="ENSMODT00000079505.1">
        <property type="protein sequence ID" value="ENSMODP00000056010.1"/>
        <property type="gene ID" value="ENSMODG00000007384.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010152"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007384">
        <property type="expression patterns" value="Expressed in liver and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="390" mass="43737" checksum="0F1C4FCAEC16FB51" modified="2019-12-11" version="1">MGRKVTVATCSLNQWALDFEGNLQRILRSIEIARNKGAKYRLGPELEICGYGCWDHFFESDTILHSYQVLAQLLMSPVTQNIICDVGMPVMHRNVRYNCRVIFLNGKILLIRPKMVLANSGNYQEMRWFAPWNKRRPRWAPSFGPQEIVPFGDIVLATRDTCIGTEICEELWMPHSPHIDMGLDGVEVFTNSSGSHHVLRKAHARVELVNLATLKNGGVYLLANQKGCDGDRLYYDGCSMISLNGATIAQGTQFSLDDVEVLTGTIDLEDIRSFRTEISASKVIPYNRVKVDFSLSCHDDFLVPPSEPFQWHFHSLGEEISLGPACWLWDYLRRSQQAGFFLPLSGGVDSSASACIVYSMCRQVCHAVSNGSKWWGAPGVSPKQVCLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7S8</accession>
    <name>A0A5F8H7S8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde oxidase</fullName>
            <ecNumber evidence="5">1.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an aldehyde + O2 + H2O = a carboxylate + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16829"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="1.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="19">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="19">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.3.1" evidence="5"/>
    <dbReference type="Ensembl" id="ENSMODT00000068267.1">
        <property type="protein sequence ID" value="ENSMODP00000055614.1"/>
        <property type="gene ID" value="ENSMODG00000041712.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183114"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000041712">
        <property type="expression patterns" value="Expressed in spermatid and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004031">
        <property type="term" value="F:aldehyde oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000025">
        <property type="entry name" value="Aldehyde oxidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014313">
        <property type="entry name" value="Aldehyde_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02969">
        <property type="entry name" value="mam_aldehyde_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 18" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 19" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="20">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="21">
        <location>
            <begin position="183"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="1216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="211"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="722"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="753"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="867"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="869"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1034"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1256" mass="138659" checksum="B2C72D0C75D72806" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7T1</accession>
    <name>A0A5F8H7T1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secernin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SCRN3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7T1"/>
    <dbReference type="Ensembl" id="ENSMODT00000084540.1">
        <property type="protein sequence ID" value="ENSMODP00000055266.1"/>
        <property type="gene ID" value="ENSMODG00000009337.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013474"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009337">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF18">
        <property type="entry name" value="SECERNIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="394" mass="45005" checksum="745208591C273437" modified="2019-12-11" version="1">MEPNSCDTFVALPPSTVGNRIIFGKNSDRPFDEVQEIIYFPAATHSLEKKLECTYIEIEQVAETYAVVLSRPSWLWGAEMGANEHGVCIGNEAVWGREEVCEEEALLGMDLVRLGLERADTAEKALNIIVDLLEKYGQGGNCSENMVFSYHNSFLIADRHEAWILETAGQYWAAEKVEEGVRNISNQLCITTKIDREHPKMREYAKSKERYCEGNKLLNKHKGNITFETMMEILRDKESGINMKGAFQTTGSMVSILPSDPSLPCIHFFTGTPHPERSVFKPFIFAPNLTHLLETISPTFGLEDPVKKHPRFQSKCDRRHPLYQRHDQAIEIMNADEEKGRKMLEEMRILEKEILKEMELVLQNKCLDENRTIDLFSQCVKNEMKIYGPIIGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7T2</accession>
    <name>A0A5F8H7T2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxyguanosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DGUOK</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCK/DGK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056670659.1">
        <property type="nucleotide sequence ID" value="XM_056814681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7T2"/>
    <dbReference type="Ensembl" id="ENSMODT00000063622.1">
        <property type="protein sequence ID" value="ENSMODP00000056015.1"/>
        <property type="gene ID" value="ENSMODG00000010511.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100023732"/>
    <dbReference type="CTD" id="1716"/>
    <dbReference type="GeneTree" id="ENSGT00940000159627"/>
    <dbReference type="OrthoDB" id="567086at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010511">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF8">
        <property type="entry name" value="DEOXYGUANOSINE KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="4">
        <location>
            <begin position="40"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="189" mass="21212" checksum="9E7F603673235349" modified="2019-12-11" version="1">MALGGPGRQLRALLRASLGPRVQGQRAESGPAPRRAPRRLAVEGNIAVGKSTFVKLLVKTFPEWHIAAEPITTWQNIQAVGTPTAGPPQSVGNLLDMMYQQPSRWSYTFQTFSLLSRLKAQLAPSPERLWQAQQPMHVFERTVYSDRLHFEHLKKTPVLVLDVNEDFSEVAAKQEELMRKVNSFVKDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7T4</accession>
    <name>A0A5F8H7T4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dachshund family transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DACH2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DACH/dachshund family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7T4"/>
    <dbReference type="Ensembl" id="ENSMODT00000064447.1">
        <property type="protein sequence ID" value="ENSMODP00000055872.1"/>
        <property type="gene ID" value="ENSMODG00000014370.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001134"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014370">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21081">
        <property type="entry name" value="DHD_Dac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.20:FF:000001">
        <property type="entry name" value="Dachshund homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052417">
        <property type="entry name" value="Dachshund_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12577">
        <property type="entry name" value="DACHSHUND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12577:SF7">
        <property type="entry name" value="DACHSHUND HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKI/SNO/DAC" evidence="5">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="696" mass="74600" checksum="D1ED01D7EA9204F2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7T5</accession>
    <name>A0A5F8H7T5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7T5"/>
    <dbReference type="Ensembl" id="ENSMODT00000085101.1">
        <property type="protein sequence ID" value="ENSMODP00000056023.1"/>
        <property type="gene ID" value="ENSMODG00000025255.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154838"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025255">
        <property type="expression patterns" value="Expressed in blood and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01469">
        <property type="entry name" value="vWA_integrins_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000005">
        <property type="entry name" value="Integrin alpha L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000004">
        <property type="entry name" value="Integrin subunit alpha M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000012">
        <property type="entry name" value="Integrin, alpha 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048633">
        <property type="entry name" value="ITGAX-like_Ig_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF118">
        <property type="entry name" value="INTEGRIN ALPHA-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00357">
        <property type="entry name" value="Integrin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21520">
        <property type="entry name" value="ITGAX-like_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0401">Integrin</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023978369" description="VWFA domain-containing protein" evidence="16">
        <location>
            <begin position="18"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1065"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="17">
        <location>
            <begin position="150"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="443"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="507"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="570"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1117" mass="123217" checksum="0DFFBA9530F983BD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7T6</accession>
    <name>A0A5F8H7T6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain containing 149</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CCDC149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC149 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7T6"/>
    <dbReference type="Ensembl" id="ENSMODT00000057334.1">
        <property type="protein sequence ID" value="ENSMODP00000055624.1"/>
        <property type="gene ID" value="ENSMODG00000000471.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015958"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000471">
        <property type="expression patterns" value="Expressed in uterine wall and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019179">
        <property type="entry name" value="CC149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09789">
        <property type="entry name" value="CC149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="138" mass="16376" checksum="54EA786A0686040F" modified="2019-12-11" version="1">MDEAMNFNRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSIPPEKRKQANLAQLLSDSRDRNKHLGEEIKELQQRLGEIQGDNKGSRRKEMKVLLLLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7T9</accession>
    <name>A0A5F8H7T9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CAP-Gly domain containing linker protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CLIP1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000076959.1">
        <property type="protein sequence ID" value="ENSMODP00000055877.1"/>
        <property type="gene ID" value="ENSMODG00000012253.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155122"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012253">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000002">
        <property type="entry name" value="CAP-Gly domain containing linker protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000001">
        <property type="entry name" value="Putative CAP-Gly domain-containing linker protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF44">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1359"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="402"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="476"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="587"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1213"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1403" mass="157727" checksum="48A910BDB9B2B81C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7U0</accession>
    <name>A0A5F8H7U0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphatidylinositol 4-kinase alpha</fullName>
            <ecNumber evidence="4">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PI4KA</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2). Interacts with TMEM150A; regulating recruitment to the plasma membrane. Interacts with TTC7A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="4"/>
    <dbReference type="Ensembl" id="ENSMODT00000072915.1">
        <property type="protein sequence ID" value="ENSMODP00000055271.1"/>
        <property type="gene ID" value="ENSMODG00000017648.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074798"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017648">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00871">
        <property type="entry name" value="PI4Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000005">
        <property type="entry name" value="Phosphatidylinositol 4-kinase, catalytic, alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-kinase, catalytic, alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-kinase, catalytic, alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="19">
        <location>
            <begin position="1161"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="18">
        <location>
            <begin position="1442"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1421"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1751"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1438"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1452"/>
            <end position="1466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1780" mass="200641" checksum="EECDEF360F8F2B32" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7U1</accession>
    <name>A0A5F8H7U1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">X-ray repair cross-complementing protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">CTC box-binding factor 85 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">DNA repair protein XRCC5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ku80</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Nuclear factor IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">XRCC5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7U1"/>
    <dbReference type="Ensembl" id="ENSMODT00000055303.1">
        <property type="protein sequence ID" value="ENSMODP00000056025.1"/>
        <property type="gene ID" value="ENSMODG00000015556.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153239"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015556">
        <property type="expression patterns" value="Expressed in hindlimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.240:FF:000001">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000005">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ku" evidence="19">
        <location>
            <begin position="188"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="606" mass="69371" checksum="92C4EC441801398D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7U5</accession>
    <name>A0A5F8H7U5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FBXO7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7U5"/>
    <dbReference type="Ensembl" id="ENSMODT00000084613.1">
        <property type="protein sequence ID" value="ENSMODP00000055276.1"/>
        <property type="gene ID" value="ENSMODG00000001336.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006670"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001336">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22087">
        <property type="entry name" value="F-box_FBXO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000010">
        <property type="entry name" value="F-box only protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047118">
        <property type="entry name" value="Fbxo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15537">
        <property type="entry name" value="F-BOX ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15537:SF2">
        <property type="entry name" value="F-BOX ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="292"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="485" mass="53875" checksum="03619D64E50EF945" modified="2019-12-11" version="1">MKLRVRVRKRTAPLELPGAEPTLGELRAHLRQALLPAWGYSSDIQFAVTLNSKDALTEDEKTLAEYGIVCGDLICLVLEEATEDLPRASLDLAHSSFASNHDQPSLATSQSLRSRQGERELNDPYSAVQSAESMPGSSLDLDSGLIQEDVDMEEGTGGYPSEPMLCSEAVDGQVPHSLEMLYHSAECSSTNDALIVLVHLLMLESGYIPLGTEAKAVSMPENWRSGGVYKLQYMHPLCEDGTAALTCVPLGSLIVINATLKINNEIRSVKRLQLLPESFICPPKQALNLPDVFGLVVLPLELKLRIFRLLDVRSVLALSAVCRDLFNASNDQLLWRFMYLRDFRDGAVRPRDTDWKELYRKQKQRKDALRWRHAMFLPPPPHPMPFHPSPFYPSPFPPNPMYPPGIIGGEFDERPVLPYVGDPINSLIPGPGEAPGQFSPFRPHFDPMGPFPGPNPVLPGRGGPSDRFPFRPSRGRPTDIRLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7U6</accession>
    <name>A0A5F8H7U6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand calcium binding domain 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EFCAB14</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7U6"/>
    <dbReference type="Ensembl" id="ENSMODT00000054661.1">
        <property type="protein sequence ID" value="ENSMODP00000056030.1"/>
        <property type="gene ID" value="ENSMODG00000001906.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011196"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001906">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042352">
        <property type="entry name" value="EFCAB14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15717:SF2">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15717">
        <property type="entry name" value="PROTEIN KIAA0494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="433" mass="47484" checksum="681040631FC492F8" modified="2019-12-11" version="1">MKKRRELNALIGLGPGDGRARRSRRSRRRAWKSAAGHRLLRTEPPASGSASSSEEEDDDDDDDDDEEDEEERGRGGPGGGRTRFARGDCFRCCKICYPLCAFVILAACVVACVGLVWMQVALKEDLDLLKEQFRVLESNQKSSFQEIPKLNEELLGKQKQLEKIESGDLGLSKVWINITEMTKQIALLTSTVNHLKTNIKSASDLISLPATVEGLQKSVASIGSTLNSVRLAVEAVQKTVDEHKKTIETLQNDMIQHFSKETSESIMATPSPSMAPGLAGKSQRENFQQKEDSPNSQASKLREKVQLINALTGKSEPNRPPENSEEGKTQSAALKPSASPKFSPRSLGAQGEKAAHLRPVSIPGISSLTDLLDLFQRMGRGPEGKLSYQDLQHLLGPAIPSAQSLAELDMDRDGSYSFPELRLALGIEHMEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7U7</accession>
    <name>A0A5F8H7U7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">FN1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7. Interacts with COMP. Interacts (via type III repeats 9-14) with TNFAIP6 (via CUB domain); this interaction enhances fibronectin fibril assembly. TNFAIP6 may act as a bridging molecule between FN1 and THBS1. Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth. Interacts with FST3 and MYOC. Interacts with SVEP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007501837.1">
        <property type="nucleotide sequence ID" value="XM_007501775.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000078262.1">
        <property type="protein sequence ID" value="ENSMODP00000056038.1"/>
        <property type="gene ID" value="ENSMODG00000015605.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100014118"/>
    <dbReference type="CTD" id="2335"/>
    <dbReference type="GeneTree" id="ENSGT00940000155126"/>
    <dbReference type="OrthoDB" id="261433at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015605">
        <property type="expression patterns" value="Expressed in liver and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006953">
        <property type="term" value="P:acute-phase response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00061">
        <property type="entry name" value="FN1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000004">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000006">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000007">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000018">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000099">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000417">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000579">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001069">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000001">
        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000017">
        <property type="entry name" value="Fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000020">
        <property type="entry name" value="fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000021">
        <property type="entry name" value="fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000022">
        <property type="entry name" value="fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000227">
        <property type="entry name" value="Fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000275">
        <property type="entry name" value="fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000300">
        <property type="entry name" value="fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000306">
        <property type="entry name" value="fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000317">
        <property type="entry name" value="fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000336">
        <property type="entry name" value="fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000364">
        <property type="entry name" value="fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000382">
        <property type="entry name" value="fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000447">
        <property type="entry name" value="fibronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000433">
        <property type="entry name" value="fibronectin isoform X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000083">
        <property type="entry name" value="Fibronectin_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF8">
        <property type="entry name" value="FIBRONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00039">
        <property type="entry name" value="fn1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00058">
        <property type="entry name" value="FN1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01253">
        <property type="entry name" value="FN1_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51091">
        <property type="entry name" value="FN1_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0011">Acute phase</keyword>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="13 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="12" id="KW-0558">Oxidation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0765">Sulfation</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023894346" description="Fibronectin" evidence="19">
        <location>
            <begin position="29"/>
            <end position="2391"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-I" evidence="21">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-I" evidence="21">
        <location>
            <begin position="100"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-I" evidence="21">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-I" evidence="21">
        <location>
            <begin position="189"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-I" evidence="21">
        <location>
            <begin position="234"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="22">
        <location>
            <begin position="360"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="22">
        <location>
            <begin position="420"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-I" evidence="21">
        <location>
            <begin position="473"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-I" evidence="21">
        <location>
            <begin position="521"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-I" evidence="21">
        <location>
            <begin position="564"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="615"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="722"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="816"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="914"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1004"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1094"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1181"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1274"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1367"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1455"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1549"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1641"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1729"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1823"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1910"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-I" evidence="21">
        <location>
            <begin position="2205"/>
            <end position="2249"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-I" evidence="21">
        <location>
            <begin position="2250"/>
            <end position="2292"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-I" evidence="21">
        <location>
            <begin position="2294"/>
            <end position="2334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="701"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1390"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1579"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1400"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1582"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2391" mass="263773" checksum="89C3846F359B6C11" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7U8</accession>
    <name>A0A5F8H7U8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DHX30</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DEAH box protein 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">DHX30</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7U8"/>
    <dbReference type="Ensembl" id="ENSMODT00000064389.1">
        <property type="protein sequence ID" value="ENSMODP00000055634.1"/>
        <property type="gene ID" value="ENSMODG00000014285.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158279"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014285">
        <property type="expression patterns" value="Expressed in testis and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17976">
        <property type="entry name" value="DEXHc_DHX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000004">
        <property type="entry name" value="ATP-dependent RNA helicase DHX30 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000016">
        <property type="entry name" value="ATP-dependent RNA helicase DHX30 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000017">
        <property type="entry name" value="ATP-dependent RNA helicase DHX30 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000414">
        <property type="entry name" value="ATP-dependent RNA helicase DHX30 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000375">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF257">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="405"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="613"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="115"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1153" mass="129582" checksum="C9B4F9010D1A4C92" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H839</accession>
    <name>A0A5F8H839_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="17">1.3.8.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">ACADVL</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:19181"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.8.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:19182"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>dodecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:47297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:43449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:74693"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:47233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:47317"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer. Homodimerizes after import into the mitochondrion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.9" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H839"/>
    <dbReference type="Ensembl" id="ENSMODT00000085940.1">
        <property type="protein sequence ID" value="ENSMODP00000056130.1"/>
        <property type="gene ID" value="ENSMODG00000006498.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158535"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006498">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017099">
        <property type="term" value="F:very-long-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01161">
        <property type="entry name" value="VLCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000008">
        <property type="entry name" value="acyl-CoA dehydrogenase family member 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000017">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000006">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF11">
        <property type="entry name" value="VERY LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="31">
        <location>
            <begin position="267"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="30">
        <location>
            <begin position="330"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="29">
        <location>
            <begin position="444"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="32">
        <location>
            <begin position="644"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00046812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="772" mass="83536" checksum="D12182F398F81EEE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H841</accession>
    <name>A0A5F8H841_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde oxidase</fullName>
            <ecNumber evidence="5">1.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an aldehyde + O2 + H2O = a carboxylate + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16829"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="1.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="19">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="19">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.3.1" evidence="5"/>
    <dbReference type="Ensembl" id="ENSMODT00000075672.1">
        <property type="protein sequence ID" value="ENSMODP00000056133.1"/>
        <property type="gene ID" value="ENSMODG00000041712.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183114"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000041712">
        <property type="expression patterns" value="Expressed in spermatid and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004031">
        <property type="term" value="F:aldehyde oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000025">
        <property type="entry name" value="Aldehyde oxidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014313">
        <property type="entry name" value="Aldehyde_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02969">
        <property type="entry name" value="mam_aldehyde_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 18" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 19" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="20">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="21">
        <location>
            <begin position="201"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="1217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="229"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="723"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="754"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="868"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="870"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1035"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1257" mass="138970" checksum="35514BF73FAD46E8" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H842</accession>
    <name>A0A5F8H842_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMMECR1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AMMECR1L</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H842"/>
    <dbReference type="Ensembl" id="ENSMODT00000083371.1">
        <property type="protein sequence ID" value="ENSMODP00000055972.1"/>
        <property type="gene ID" value="ENSMODG00000018651.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010397"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018651">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.700.20:FF:000001">
        <property type="entry name" value="AMME syndrome candidate gene 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF1">
        <property type="entry name" value="AMMECR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="97"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="282" mass="31192" checksum="71221874C83209A4" modified="2019-12-11" version="1">MGKRRCVPPLEPKLAAGCCGVKKPKLSGSGTHSHGNQSTTVPGSSSGPLQNHQHVDGSNGRENVSDLTLGPGNSPITRMNPTSGALSPLSRPNGTANTTKNLVVTAEMCCYCFDVLYCHLYGFPQPRLPRFTNDPYPLFVTWKTGRDKRLRGCIGTFSAMNLHSGLREYTLTSALKDSRFPPLTREELPKLFCSVSLLTNFEDASDYLDWEVGVHGIRIEFINEKGVKRTATYLPEVAKEQDWDQIQTIDSLLRKGGFKAPITNEFRKTIKLTSHIPVKIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H843</accession>
    <name>A0A5F8H843_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein light chain Tctex-type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DYNLT2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001381627.1">
        <property type="nucleotide sequence ID" value="XM_001381590.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H843"/>
    <dbReference type="Ensembl" id="ENSMODT00000052444.1">
        <property type="protein sequence ID" value="ENSMODP00000055371.1"/>
        <property type="gene ID" value="ENSMODG00000040827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100032672"/>
    <dbReference type="KEGG" id="mdo:100032672"/>
    <dbReference type="CTD" id="6991"/>
    <dbReference type="GeneTree" id="ENSGT00940000160069"/>
    <dbReference type="OrthoDB" id="49386at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000040827">
        <property type="expression patterns" value="Expressed in spermatocyte and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd21460">
        <property type="entry name" value="DLC-like_TCTEX1D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF27">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="211" mass="24204" checksum="E7E1EA7EC2BC556D" modified="2019-12-11" version="1">MEKRNAPGHSSLSSRGTKAPAMPTASSPAGPSGPSGPPGKRERRPSMFEKESYAQILRERLRESVHDVLYVEPPFDDAIADIGKDQWKTMTGKVKYANTYRMEPYQKFQAQRVQKKVQQILTDRLHKVKYNEETFSSLSVELADRILAAVKEFPFTRYKYIVKIILIQKTGQSINISSRWIWDVAWDTWLEAKHEAESYVALALVYALYCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H845</accession>
    <name>A0A5F8H845_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">MAPT</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 18">Cytoplasm</location>
            <location evidence="1 18">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H845"/>
    <dbReference type="Ensembl" id="ENSMODT00000073796.1">
        <property type="protein sequence ID" value="ENSMODP00000055734.1"/>
        <property type="gene ID" value="ENSMODG00000010958.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155494"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010958">
        <property type="expression patterns" value="Expressed in testis and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002955">
        <property type="entry name" value="Tau"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF14">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN TAU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01261">
        <property type="entry name" value="TAUPROTEIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16 18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 18" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="233"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="466"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="938"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="940"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="984" mass="105008" checksum="91624B32B33DFA35" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H846</accession>
    <name>A0A5F8H846_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LDL receptor related protein 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LRP1B</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H846"/>
    <dbReference type="Ensembl" id="ENSMODT00000066199.1">
        <property type="protein sequence ID" value="ENSMODP00000056138.1"/>
        <property type="gene ID" value="ENSMODG00000002847.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157521"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002847">
        <property type="expression patterns" value="Expressed in spinal cord and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000015">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="73" mass="8304" checksum="4849A49427610DD8" modified="2019-12-11" version="1">MSRLLFFSRFSGRPMILKLSLLDLFPDPQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESIDTYFSTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H848</accession>
    <name>A0A5F8H848_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Adaptor related protein complex 1 subunit sigma 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">AP1S3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007502259.1">
        <property type="nucleotide sequence ID" value="XM_007502197.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H848"/>
    <dbReference type="Ensembl" id="ENSMODT00000088053.1">
        <property type="protein sequence ID" value="ENSMODP00000056140.1"/>
        <property type="gene ID" value="ENSMODG00000021198.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022527"/>
    <dbReference type="KEGG" id="mdo:100022527"/>
    <dbReference type="CTD" id="130340"/>
    <dbReference type="GeneTree" id="ENSGT00970000193372"/>
    <dbReference type="OMA" id="ETMAEYM"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021198">
        <property type="expression patterns" value="Expressed in placenta and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000005">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="12">
        <location>
            <begin position="62"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="215" mass="24853" checksum="CF02E2DA5782A505" modified="2019-12-11" version="1">MFVHGLPDAARESPSVLSAWVPRKPKGAVSFRLPPVGFLPGRPGVPREQGPAGREPRTPVAQIHFILLFSRQGKLRLQKWYTTLPDKERKKIIREIVQMILSRGQRTSSFVDWKDLKLVYKRYASLYFCCAVENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIMGGEIQETSKKSAVKAIEDSDMLQETMEEYMSKPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H852</accession>
    <name>A0A5F8H852_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxiredoxin like 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PRXL2C</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H852"/>
    <dbReference type="FunCoup" id="A0A5F8H852">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055381"/>
    <dbReference type="Ensembl" id="ENSMODT00000084017.1">
        <property type="protein sequence ID" value="ENSMODP00000055381.1"/>
        <property type="gene ID" value="ENSMODG00000036541.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048363"/>
    <dbReference type="InParanoid" id="A0A5F8H852"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000036541">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045821">
        <property type="term" value="P:positive regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="263" mass="29810" checksum="A8A3AE21C571442B" modified="2019-12-11" version="1">MASSTSQADEILVTRQICSLGLLPPPKSQCGVPLAEDVAELSVQDASGKGIPFGELFRERRAIVVFVRHFLCYTCKEYVEDLAKIPKSFLQDANVTLIVIGQSSFQHIEPFCKLTRYSHEIYVDTERKIYRKLGMNKGEGIASSEQSPHVKSNLLSGSIQSLWRAVTGPAFDFQGDPAQQGGTLILGPAGEKRKAKKISSETSMRLNKLWYLLVMEYYCAKRNNKVEEFHGDWNNLQEVMQSERSRTRKTLYTETDTLWYNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H853</accession>
    <name>A0A5F8H853_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC103094333</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056681038.1">
        <property type="nucleotide sequence ID" value="XM_056825060.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056681039.1">
        <property type="nucleotide sequence ID" value="XM_056825061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H853"/>
    <dbReference type="Ensembl" id="ENSMODT00000073411.1">
        <property type="protein sequence ID" value="ENSMODP00000055744.1"/>
        <property type="gene ID" value="ENSMODG00000048900.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103094333"/>
    <dbReference type="GeneTree" id="ENSGT00940000161954"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000048900">
        <property type="expression patterns" value="Expressed in endometrium and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003698">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000292">
        <property type="entry name" value="zinc finger protein 619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="425" mass="49493" checksum="BDD2515211B9E2A5" modified="2019-12-11" version="1">MTFERDGLPAQEVVTFQDVAVDFTREEWRLLSPPQKELYKEVMLENVRNLLSVGEIRPEMKVNPSEVSLPVEEMDLQRFMSDGLDNFASRKFCVAPQNSSHIEHQRMHTEEKSSERNQCRKTLMHRASLAGHQKIHTGEKPYECKECGKKFRQSSDLAVHQRIHTGDKPYECKQCGKSFSQSSHLARHQRIHTGEKPYECKQCGKAFSQSSCLVLHQRIHTGEKPYECKECGKTFSMSSHLAVHQRIHTGEKPYECKECGKTFRLSSSLAVHQRIHTGEKPYECKQCGKTFSRSYYLAVHQRMHTGEKPYECKQCGKMFSRSSHLVVHQRTHTGERPFECNQCGKTFKERSKLAVHRRTHTGEKPYECKQCGKTFGRSCYLSVHQRIHIGRNLKNTRYMENVHMQFQSCYWVKEIYPSPFLGQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H856</accession>
    <name>A0A5F8H856_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Collagen type IV alpha 2 chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">COL4A2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000081891.1">
        <property type="protein sequence ID" value="ENSMODP00000056148.1"/>
        <property type="gene ID" value="ENSMODG00000004632.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157234"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004632">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF5">
        <property type="entry name" value="COLLAGEN TYPE XIII ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="8" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Collagen IV NC1" evidence="11">
        <location>
            <begin position="1126"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="462"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="680"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="872"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="934"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1349" mass="133829" checksum="67A4AE4719120ADC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H859</accession>
    <name>A0A5F8H859_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat and coiled-coil-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC100030951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H859"/>
    <dbReference type="Ensembl" id="ENSMODT00000070389.1">
        <property type="protein sequence ID" value="ENSMODP00000056150.1"/>
        <property type="gene ID" value="ENSMODG00000025443.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001660"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025443">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028041">
        <property type="entry name" value="WDCP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14897">
        <property type="entry name" value="WD REPEAT AND COILED-COIL-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14897:SF5">
        <property type="entry name" value="WD REPEAT AND COILED-COIL-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15390">
        <property type="entry name" value="WDCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="776" mass="84426" checksum="0605684C2AE71880" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H861</accession>
    <name>A0A5F8H861_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="20">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">IGF1R</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H861"/>
    <dbReference type="Ensembl" id="ENSMODT00000070456.1">
        <property type="protein sequence ID" value="ENSMODP00000055987.1"/>
        <property type="gene ID" value="ENSMODG00000012761.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156682"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012761">
        <property type="expression patterns" value="Expressed in uterine wall and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005010">
        <property type="term" value="F:insulin-like growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05032">
        <property type="entry name" value="PTKc_InsR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF106">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 20" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="23">
        <location>
            <begin position="691"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="846"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1149"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1160"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="880"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1208" mass="137575" checksum="1A86251B9F2A41F4" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H866</accession>
    <name>A0A5F8H866_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase 1 regulatory subunit 1B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DARPP-32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Dopamine- and cAMP-regulated neuronal phosphoprotein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PPP1R1B</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibitor of protein-phosphatase 1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein phosphatase inhibitor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H866"/>
    <dbReference type="Ensembl" id="ENSMODT00000067750.1">
        <property type="protein sequence ID" value="ENSMODP00000055992.1"/>
        <property type="gene ID" value="ENSMODG00000012788.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111283"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012788">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008466">
        <property type="entry name" value="PPP1R1A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15417:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15417">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05395">
        <property type="entry name" value="DARPP-32"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="174" mass="19391" checksum="172C48C80F0C99FE" modified="2019-12-11" version="1">MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRVSEHSSPAVQRIAESHLQSISNLSENQPSDEEEEEEGEQGSRGCQGEEEEEEEEEEEEEDDSSQAEVVKGRNKPAVQQTSCGQGLEGPWERPPPLDEPQKDGTSEGKEEGEEEEVVQNEPDEGTQHPGPPAPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H868</accession>
    <name>A0A5F8H868_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KIF9</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H868"/>
    <dbReference type="Ensembl" id="ENSMODT00000088395.1">
        <property type="protein sequence ID" value="ENSMODP00000055396.1"/>
        <property type="gene ID" value="ENSMODG00000014066.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158533"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014066">
        <property type="expression patterns" value="Expressed in ovary and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056524">
        <property type="entry name" value="KIF6/9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF62">
        <property type="entry name" value="KINESIN FAMILY MEMBER 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23735">
        <property type="entry name" value="KIF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023909426" description="Kinesin-like protein" evidence="12">
        <location>
            <begin position="23"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="445"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="696" mass="79010" checksum="354EB7CF5547690A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F6X4M8</accession>
    <name>F6X4M8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TANC2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Postsynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TANC family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000012881.5">
        <property type="protein sequence ID" value="ENSMODP00000012651.5"/>
        <property type="gene ID" value="ENSMODG00000010102.5"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156447"/>
    <dbReference type="HOGENOM" id="CLU_001464_0_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010102">
        <property type="expression patterns" value="Expressed in cerebellum and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000022">
        <property type="entry name" value="protein TANC2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000036">
        <property type="entry name" value="protein TANC2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000044">
        <property type="entry name" value="Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058018">
        <property type="entry name" value="AAA_lid_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058056">
        <property type="entry name" value="WH_TANC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF21">
        <property type="entry name" value="PROTEIN TANC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25520">
        <property type="entry name" value="AAA_lid_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25521">
        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 9" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="TANC1/2-like AAA+ ATPase lid" evidence="12">
        <location>
            <begin position="611"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="TANC1/2-like winged helix" evidence="13">
        <location>
            <begin position="707"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="930"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1046"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1079"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1112"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1145"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1178"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1267"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1314"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1348"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1452"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1800"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1984"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1381"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1486"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1570"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1800"/>
            <end position="1815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000012651.5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2007" mass="221786" checksum="455230E90F91D270" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>F6Y7R9</accession>
    <name>F6Y7R9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">GRIA2</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18 23">Postsynaptic cell membrane</location>
            <topology evidence="18 23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6Y7R9"/>
    <dbReference type="STRING" id="13616.ENSMODP00000036431"/>
    <dbReference type="Ensembl" id="ENSMODT00000038021.3">
        <property type="protein sequence ID" value="ENSMODP00000036431.1"/>
        <property type="gene ID" value="ENSMODG00000001807.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156950"/>
    <dbReference type="HOGENOM" id="CLU_007257_1_2_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001807">
        <property type="expression patterns" value="Expressed in cerebellum and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004970">
        <property type="term" value="F:glutamate-gated receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06389">
        <property type="entry name" value="PBP1_iGluR_AMPA_GluR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13715">
        <property type="entry name" value="PBP2_iGluR_AMPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000067">
        <property type="entry name" value="glutamate receptor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000099">
        <property type="entry name" value="glutamate receptor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000001">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000004">
        <property type="entry name" value="Glutamate receptor, ionotropic, AMPA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000666">
        <property type="entry name" value="Glutamate receptor, ionotropic, AMPA 2a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 23" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 23" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 23" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 23" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14 23" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12 23" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 23" id="KW-0732">Signal</keyword>
    <keyword evidence="7 23" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 23" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027143130" description="Glutamate receptor" evidence="23">
        <location>
            <begin position="22"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="24">
        <location>
            <begin position="415"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="25">
        <location>
            <begin position="425"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="21">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="21">
        <location>
            <position position="654"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="21">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="21">
        <location>
            <position position="773"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="78"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="739"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU367118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000036431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="883" mass="98948" checksum="59D7B8509CB40C11" modified="2011-07-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F7C216</accession>
    <name>F7C216_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">A-type potassium channel modulatory protein DPP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dipeptidyl aminopeptidase-like protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dipeptidyl peptidase 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Dipeptidyl peptidase VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DPP6</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homodimer (in vitro). Interacts with KCND2. Identified in a complex with KCND2 and KCNIP2. Forms an octameric complex composed of four DPP6 subunits bound to the KCND2 tetramer. Interacts with KCND3; this interaction modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7C216"/>
    <dbReference type="MEROPS" id="S09.973"/>
    <dbReference type="Ensembl" id="ENSMODT00000006162.3">
        <property type="protein sequence ID" value="ENSMODP00000006034.3"/>
        <property type="gene ID" value="ENSMODG00000004898.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156280"/>
    <dbReference type="HOGENOM" id="CLU_006105_4_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004898">
        <property type="expression patterns" value="Expressed in cerebellum and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7C216">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF20">
        <property type="entry name" value="DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="16">
        <location>
            <begin position="51"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="15">
        <location>
            <begin position="498"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000006034.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="725" mass="82953" checksum="8D3F72FDF51AD50D" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>F7CSM8</accession>
    <name>F7CSM8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DAPK2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_016283149.1">
        <property type="nucleotide sequence ID" value="XM_016427663.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016283150.1">
        <property type="nucleotide sequence ID" value="XM_016427664.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7CSM8"/>
    <dbReference type="STRING" id="13616.ENSMODP00000004265"/>
    <dbReference type="Ensembl" id="ENSMODT00000004355.4">
        <property type="protein sequence ID" value="ENSMODP00000004265.3"/>
        <property type="gene ID" value="ENSMODG00000010926.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100023465"/>
    <dbReference type="KEGG" id="mdo:100023465"/>
    <dbReference type="CTD" id="23604"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153424"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_55_1"/>
    <dbReference type="InParanoid" id="F7CSM8"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010926">
        <property type="expression patterns" value="Expressed in liver and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043276">
        <property type="term" value="P:anoikis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990266">
        <property type="term" value="P:neutrophil migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000424">
        <property type="term" value="P:positive regulation of eosinophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090023">
        <property type="term" value="P:positive regulation of neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001242">
        <property type="term" value="P:regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14196">
        <property type="entry name" value="STKc_DAPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000110">
        <property type="entry name" value="Death-associated kinase 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000250">
        <property type="entry name" value="Death-associated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF15">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000004265.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="490" mass="56253" checksum="CFD1B81D14F77114" modified="2013-01-09" version="2">MRSPNMATFKQQKVEDVYEIGEELGSGQFAIVKKCREKSTGAEYAAKFIKKRQSRASRRGVQREEIEREVHILQQVLHPNVIKLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILEGVNYLHAKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALTHPWITSKGEAKALEPRKTEPPQLKTKRLREYTIKCHSSMPRNNTYVNFERFARVVEDVADVEQSCNTLATAHDSLQDDVEALLSIYNEKEAWYREESENTRYSLSQLKYEYRKVEAMKKALREDIQTAYSDLGSVAGKYAQLGTQYEALRRELSEDLRWIQDLMSDFQQEKGSEESLGSDFNRDVNTSLMELLNRSCSEDFLAGLKLRVTESSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>F7D4L4</accession>
    <name>F7D4L4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CCNH</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7D4L4"/>
    <dbReference type="Ensembl" id="ENSMODT00000025752.4">
        <property type="protein sequence ID" value="ENSMODP00000025303.3"/>
        <property type="gene ID" value="ENSMODG00000020228.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008634"/>
    <dbReference type="HOGENOM" id="CLU_022620_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020228">
        <property type="expression patterns" value="Expressed in hindlimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000029">
        <property type="entry name" value="Cyclin h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027081">
        <property type="entry name" value="CyclinH/Ccl1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00569">
        <property type="entry name" value="ccl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000025303.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="243" mass="28082" checksum="1CE5E3ACA37BE3AA" modified="2019-12-11" version="2">MPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSAQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEVLRKTADDFLNRIALTDAYLLYTPSQIALTTILSSASRAGINMESYLSESLMLKENRTCLSQLLDTMKCMKNLVKKYEPPRPEEVAALKQKLEKCHSAELAFNINAKKRKGYEDDEYVSKKSKLEEYILKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F7D4M7</accession>
    <name>F7D4M7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 161B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TMEM161B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM161 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016287057.1">
        <property type="nucleotide sequence ID" value="XM_016431571.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7D4M7"/>
    <dbReference type="Ensembl" id="ENSMODT00000025750.4">
        <property type="protein sequence ID" value="ENSMODP00000025301.4"/>
        <property type="gene ID" value="ENSMODG00000020226.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013491"/>
    <dbReference type="CTD" id="153396"/>
    <dbReference type="eggNOG" id="KOG3978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000672"/>
    <dbReference type="HOGENOM" id="CLU_027277_0_0_1"/>
    <dbReference type="OrthoDB" id="784140at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020226">
        <property type="expression patterns" value="Expressed in endometrium and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019395">
        <property type="entry name" value="Transmembrane_161A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13624">
        <property type="entry name" value="RE42071P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13624:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 161B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10268">
        <property type="entry name" value="Tmemb_161AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000025301.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="464" mass="52924" checksum="EDBF2FB4A6A1AAB8" modified="2019-12-11" version="3">MAVSYLAPLFLESLRWYQHPTEEELRLLAGKQQRGKSKKDRKYNGHIENKPLTIPKDIDLHLETKSITEVDTLALHYFPEYQWLVDFTVAATIVYLVTEVYYSLMKPTQEMNISIVWCLLVLTFAIKVLFSLTTHYFKVEEGGERSVCVTFGFFFFVKAMAILIVTENYLEFGLETGFTNFSESAMQFLEKQGLESQGPVSKLTFKFFLAILCSLIGAFLTFPGLRLAQMHLDALNLATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGKESVPLMTETTFDTMRLWLIILLCALRLALMRNHLQAYLNLAQKCVDQMKKEAGRISTIDLQKMVARVFYYLCVIALQYVAPLVMLLHTTLLLKTLGNHSWGIYPESSSDSSVENHSFSGSVYSESPSPDDKMKVTVTQITTALGSLKTIFTPLLFRGLLSFLTWWIAACLFATSLFGLFYHQYLTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F7E7P0</accession>
    <name>F7E7P0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-adenosyl-L-homocysteine hydrolase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="5">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7E7P0"/>
    <dbReference type="Ensembl" id="ENSMODT00000018673.3">
        <property type="protein sequence ID" value="ENSMODP00000018340.3"/>
        <property type="gene ID" value="ENSMODG00000014672.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182981"/>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014672">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7E7P0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000002">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000007">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000035">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000009">
        <property type="entry name" value="Adenosylhomocysteinase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF2">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="8">
        <location>
            <begin position="243"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="274"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000018340.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="483" mass="53932" checksum="1E44926B97FF71BA" modified="2019-12-11" version="2">LKKKKEMGVLPHKKDSTYTFQILQGVDDSGLSASYTDSSDDETSPRDKQQKNSKGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAVLMETLSALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4L3</accession>
    <name>A0A5F8G4L3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4L3"/>
    <dbReference type="STRING" id="13616.ENSMODP00000023389"/>
    <dbReference type="Ensembl" id="ENSMODT00000088354.1">
        <property type="protein sequence ID" value="ENSMODP00000042392.1"/>
        <property type="gene ID" value="ENSMODG00000036508.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286984"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000036508">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000003">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="80"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="204" mass="22346" checksum="6D20930032A13414" modified="2019-12-11" version="1">MAVLSAYDDTPEKPPMRGRCLPSLHLHMSTISSGARLSRFTSFVPELVASSVFSPFPAFAMPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSKSAFSPCSAILARLRGERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4L5</accession>
    <name>A0A5F8G4L5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Piezo type mechanosensitive ion channel component 1 (Er blood group)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PIEZO1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000084136.1">
        <property type="protein sequence ID" value="ENSMODP00000042379.1"/>
        <property type="gene ID" value="ENSMODG00000004122.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157348"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004122">
        <property type="expression patterns" value="Expressed in lung and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF5">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="758"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="856"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="913"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="941"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="969"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1148"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1177"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1214"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1585"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1613"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1639"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1697"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1878"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1921"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1949"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1982"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2091"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2348"/>
            <end position="2371"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM1-24" evidence="15">
        <location>
            <begin position="330"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="13">
        <location>
            <begin position="1071"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo transmembrane helical unit" evidence="14">
        <location>
            <begin position="1595"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="16">
        <location>
            <begin position="1876"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="12">
        <location>
            <begin position="2151"/>
            <end position="2435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1288"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1347"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1471"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1726"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1775"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1347"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1478"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1500"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1735"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1799"/>
            <end position="1809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2437" mass="280186" checksum="5FC3BCCA5DA42A2B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4L6</accession>
    <name>A0A5F8G4L6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline rich coiled-coil 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PRRC2A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4L6"/>
    <dbReference type="Ensembl" id="ENSMODT00000067008.1">
        <property type="protein sequence ID" value="ENSMODP00000042385.1"/>
        <property type="gene ID" value="ENSMODG00000015695.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183161"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015695">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033184">
        <property type="entry name" value="PRRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038">
        <property type="entry name" value="BAT2 HLA-B-ASSOCIATED TRANSCRIPT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038:SF5">
        <property type="entry name" value="PROTEIN PRRC2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="815" mass="85114" checksum="4FA7367403E5BC33" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4L9</accession>
    <name>A0A5F8G4L9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box protein 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FBXO33</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007473223.1">
        <property type="nucleotide sequence ID" value="XM_007473161.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4L9"/>
    <dbReference type="Ensembl" id="ENSMODT00000068094.1">
        <property type="protein sequence ID" value="ENSMODP00000042423.1"/>
        <property type="gene ID" value="ENSMODG00000011840.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100029327"/>
    <dbReference type="CTD" id="254170"/>
    <dbReference type="GeneTree" id="ENSGT00390000017718"/>
    <dbReference type="OrthoDB" id="8757000at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011840">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd22104">
        <property type="entry name" value="F-box_FBXO33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF3">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="526" mass="58385" checksum="2FD0683E012CF221" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4M1</accession>
    <name>A0A5F8G4M1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein disulfide-isomerase TMX3</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Thioredoxin domain-containing protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Thioredoxin-related transmembrane protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TMX3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_016287192.1">
        <property type="nucleotide sequence ID" value="XM_016431706.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016287193.1">
        <property type="nucleotide sequence ID" value="XM_016431707.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056679582.1">
        <property type="nucleotide sequence ID" value="XM_056823604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4M1"/>
    <dbReference type="Ensembl" id="ENSMODT00000068911.1">
        <property type="protein sequence ID" value="ENSMODP00000042386.1"/>
        <property type="gene ID" value="ENSMODG00000021402.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100020230"/>
    <dbReference type="CTD" id="54495"/>
    <dbReference type="GeneTree" id="ENSGT00930000151022"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021402">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000115">
        <property type="entry name" value="protein disulfide-isomerase TMX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000121">
        <property type="entry name" value="protein disulfide-isomerase TMX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="20">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="404"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="446" mass="51539" checksum="5CBAA6727BBC65C0" modified="2019-12-11" version="1">MSGDKFKSYDMEGLRTIYYGSSTGGPGQDPSHLVAEKFYAPWCAHCRRLEPVWNEVGLEMRKLQSPVKVGKMDATSYTSIASEFGVRGYPTIKLLKNDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHVKKRHRVLFLYVGGESPLKEKYIEVASELIVYTYFFSASEEVIPEYVTLNEMPAVLVFKDETYFVYDEYEDGDLKSWVNRERFQSYLTVDGFTLYELTDTGKLIIIAVIDGKNATIEHTRMKEFVQEVAKDYRNRFHRRDFQFGHIDGTDYVNNMLMEELNVPTVVIINTSNHQYYLPTRHIETLEDVMQFINDILDGTIEGRGGDGILQRLKRIFYDIRTTVVSVFRSSPFLGCFLFGLPLGVISIMCYGIYTADTDVAYTEERIEVSKTEIETRDENNEEEKKEENNENSLVLSDAEQEPKDIMEKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4M4</accession>
    <name>A0A5F8G4M4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Integrin subunit alpha 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ITGA9</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4M4"/>
    <dbReference type="Ensembl" id="ENSMODT00000054631.1">
        <property type="protein sequence ID" value="ENSMODP00000042428.1"/>
        <property type="gene ID" value="ENSMODG00000013303.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156503"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013303">
        <property type="expression patterns" value="Expressed in hindlimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000002">
        <property type="entry name" value="Integrin, alpha 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1530:FF:000005">
        <property type="entry name" value="Integrin, alpha 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF69">
        <property type="entry name" value="INTEGRIN ALPHA-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="911"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="38"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="293"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="354"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="406"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="14">
        <location>
            <begin position="452"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="608"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="16">
        <location>
            <begin position="709"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="968" mass="107145" checksum="7D1ED0D66C609FA4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4M5</accession>
    <name>A0A5F8G4M5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase C-binding protein NELL2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEL-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NELL2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4M5"/>
    <dbReference type="Ensembl" id="ENSMODT00000052592.1">
        <property type="protein sequence ID" value="ENSMODP00000042389.1"/>
        <property type="gene ID" value="ENSMODG00000018531.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00810000125439"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018531">
        <property type="expression patterns" value="Expressed in spinal cord and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000120">
        <property type="entry name" value="Protein kinase C-binding protein NELL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000211">
        <property type="entry name" value="Protein kinase C-binding protein NELL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000015">
        <property type="entry name" value="protein kinase C-binding protein NELL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000102">
        <property type="entry name" value="Protein kinase C-binding protein NELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000111">
        <property type="entry name" value="Protein kinase C-binding protein NELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000023">
        <property type="entry name" value="protein kinase C-binding protein NELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051586">
        <property type="entry name" value="PKC-binding_NELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042">
        <property type="entry name" value="NEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042:SF0">
        <property type="entry name" value="PROTEIN KINASE C-BINDING PROTEIN NELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023877485" description="Protein kinase C-binding protein NELL2" evidence="10">
        <location>
            <begin position="18"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="12">
        <location>
            <begin position="274"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="399"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="484"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="525"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="557"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="12">
        <location>
            <begin position="593"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="12">
        <location>
            <begin position="653"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="771" mass="86352" checksum="1BA2F134E0CEE0EF" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4M8</accession>
    <name>A0A5F8G4M8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Solute carrier family 7 member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SLC7A1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginine(in) = L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:32143"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(in) = L-lysine(out)</text>
            <dbReference type="Rhea" id="RHEA:70935"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-ornithine(in) = L-ornithine(out)</text>
            <dbReference type="Rhea" id="RHEA:71199"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4M8"/>
    <dbReference type="Ensembl" id="ENSMODT00000064452.1">
        <property type="protein sequence ID" value="ENSMODP00000042407.1"/>
        <property type="gene ID" value="ENSMODG00000009198.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155349"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009198">
        <property type="expression patterns" value="Expressed in endometrium and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000009">
        <property type="entry name" value="Low affinity cationic amino acid transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004755">
        <property type="entry name" value="Cat_AA_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00906">
        <property type="entry name" value="2A0303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF28">
        <property type="entry name" value="HIGH AFFINITY CATIONIC AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="505" mass="54428" checksum="D6479381DA3F191E" modified="2019-12-11" version="1">MGCKVFLNFGQQLLRRKVVDCNREESRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARKNAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGKPIGEFSQTHMSLDTPGLAQYPDIFSVIIILILTALLTFGVKESAMVNKVFTCINVLVLGFVMVSGFVKGSINNWQLKEDIPDNICLNNNSTIGAGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFVAYFGVSAALTLMTPYFCLDVNSPLPDAFKHVGWEGAKYAVSVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFKFLAKVSERTKTPMIATITSGAIAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMVPFLPLLPILSIFVNVYLMMQLDGGTWVRFAVWMLIGFFIYFGYGLWHSEEASLAAGTARTPDNSSDHCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4M9</accession>
    <name>A0A5F8G4M9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Spen family transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SPEN</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM Spen family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000069030.1">
        <property type="protein sequence ID" value="ENSMODP00000042433.1"/>
        <property type="gene ID" value="ENSMODG00000003411.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100017979"/>
    <dbReference type="CTD" id="23013"/>
    <dbReference type="GeneTree" id="ENSGT00940000157087"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003411">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12348">
        <property type="entry name" value="RRM1_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12350">
        <property type="entry name" value="RRM3_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12351">
        <property type="entry name" value="RRM4_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21543">
        <property type="entry name" value="SPOC_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000118">
        <property type="entry name" value="msx2-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000143">
        <property type="entry name" value="msx2-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000150">
        <property type="entry name" value="msx2-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000002">
        <property type="entry name" value="Spen family transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049095">
        <property type="entry name" value="MINT_MID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049093">
        <property type="entry name" value="MINT_RID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034172">
        <property type="entry name" value="SHARP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034174">
        <property type="entry name" value="SHARP_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034175">
        <property type="entry name" value="SHARP_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010912">
        <property type="entry name" value="SPOC_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20809">
        <property type="entry name" value="MINT_MID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20810">
        <property type="entry name" value="MINT_RID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50917">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="372"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="451"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="SPOC" evidence="12">
        <location>
            <begin position="3307"/>
            <end position="3473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="226"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="602"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="860"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1019"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1311"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1424"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1540"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1661"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2151"/>
            <end position="2382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2413"/>
            <end position="2493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2526"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2585"/>
            <end position="2656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2695"/>
            <end position="2731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2751"/>
            <end position="2784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2822"/>
            <end position="2895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3052"/>
            <end position="3129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3148"/>
            <end position="3243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3272"/>
            <end position="3298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="246"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="603"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="707"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="779"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="867"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1097"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1173"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1225"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1447"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1540"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1601"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1712"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1788"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1810"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1828"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1863"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1899"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1972"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1991"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2026"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2061"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2109"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2165"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2269"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="2294"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2336"/>
            <end position="2350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2352"/>
            <end position="2374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="2420"/>
            <end position="2432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2601"/>
            <end position="2616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2645"/>
            <end position="2656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2751"/>
            <end position="2761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2822"/>
            <end position="2840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="3052"/>
            <end position="3062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="3103"/>
            <end position="3115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="3186"/>
            <end position="3225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="3473" mass="386908" checksum="702EB3C786E1F0FD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4N0</accession>
    <name>A0A5F8G4N0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal transducer and activator of transcription</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">STAT3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the transcription factor STAT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4N0"/>
    <dbReference type="Ensembl" id="ENSMODT00000064299.1">
        <property type="protein sequence ID" value="ENSMODP00000042394.1"/>
        <property type="gene ID" value="ENSMODG00000028212.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244905"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000028212">
        <property type="expression patterns" value="Expressed in uterine wall and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071345">
        <property type="term" value="P:cellular response to cytokine stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043434">
        <property type="term" value="P:response to peptide hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10374">
        <property type="entry name" value="SH2_STAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16853">
        <property type="entry name" value="STAT3_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16847">
        <property type="entry name" value="STAT3_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000012">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.532.10:FF:000001">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.20:FF:000003">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000003">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.630:FF:000012">
        <property type="entry name" value="Signal transducer and activator of transcription 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.20">
        <property type="entry name" value="STAT transcription factor, all-alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.630">
        <property type="entry name" value="STAT transcription factor, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.532.10">
        <property type="entry name" value="STAT transcription factor, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035855">
        <property type="entry name" value="STAT3_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048988">
        <property type="entry name" value="STAT_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036535">
        <property type="entry name" value="STAT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013800">
        <property type="entry name" value="STAT_TF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015988">
        <property type="entry name" value="STAT_TF_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013801">
        <property type="entry name" value="STAT_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013799">
        <property type="entry name" value="STAT_TF_prot_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01017">
        <property type="entry name" value="STAT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02864">
        <property type="entry name" value="STAT_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02865">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21354">
        <property type="entry name" value="STAT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00964">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47655">
        <property type="entry name" value="STAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48092">
        <property type="entry name" value="Transcription factor STAT-4 N-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0010">Activator</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="580"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="780" mass="88803" checksum="0B720F5B0E0693CB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4N1</accession>
    <name>A0A5F8G4N1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4N1"/>
    <dbReference type="Ensembl" id="ENSMODT00000060655.1">
        <property type="protein sequence ID" value="ENSMODP00000042400.1"/>
        <property type="gene ID" value="ENSMODG00000042170.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000042170">
        <property type="expression patterns" value="Expressed in spermatid and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="100"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="189"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="276"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="365"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="477" mass="52111" checksum="4286F6B1671DF2A8" modified="2019-12-11" version="1">SQYGILLFLPDGPDIATIVHSANEYPPGANITLSCVADSNPAAQFTWLHNGQPVSNSATFSIIASLSDAGTYTCTASNSFTGLTHTATKNIIIYAPLSKPTIVTSNITAVETKDFSLTCQATGQIHAYQWFINRVAPAGSRIQLSPDKRTLTVSRLTRRDNKGPYECEIRNPFYSNRSDPFTLDVAYGPDIATIDHISDQFATGINVTLSCVADSNPPAQFTWLQNGKSVNNSASFSIITSLNHIGNYTCIATNSFTGLTRTANKTLMIYAPLSKPTIVTSNNTAVETKDFSMTCNATGQIHAYQWFINGVAPDGRRIQLSPDRRTLTLSSLTRFDNKGPFVCEIENPLFRNRSDPFPLNVTYGPDIATIVRSAGVYPTGVNITLSCVADSNPPAQFTWLQNGQSVSNSAIFSVISSLNHAGTYTCIASNSFTGMTRTATKNIIIYGEYLDWATNFVLGFLFPWYERNRHKIFCLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4N3</accession>
    <name>A0A5F8G4N3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mal, T cell differentiation protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MAL2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4N3"/>
    <dbReference type="Ensembl" id="ENSMODT00000087153.1">
        <property type="protein sequence ID" value="ENSMODP00000042412.1"/>
        <property type="gene ID" value="ENSMODG00000004011.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159514"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004011">
        <property type="expression patterns" value="Expressed in liver and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013295">
        <property type="entry name" value="MAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF42">
        <property type="entry name" value="PROTEIN MAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01884">
        <property type="entry name" value="MALPROTEIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="29"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="214" mass="24414" checksum="EF8C48E526A17490" modified="2019-12-11" version="1">MSWLLPHLTTSLIKIVESMPAFQNINPNLLPAALMELVTKNKLFGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLCVFLSGMVNRIDANWNFLDFAYHFVVFVFYFGAFLLEAAATSLHNLHCNVTMNVQPLLNDNQYNVNVAATVSVNDPFCFLFNYNPSLMLRTFNIPQSLKGTFKPCGRNIFFCFIFCRHLMGFVSEFYLPFNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4N4</accession>
    <name>A0A5F8G4N4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc finger protein 420-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4N4"/>
    <dbReference type="Ensembl" id="ENSMODT00000087941.1">
        <property type="protein sequence ID" value="ENSMODP00000042438.1"/>
        <property type="gene ID" value="ENSMODG00000025637.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154650"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025637">
        <property type="expression patterns" value="Expressed in testis and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000040">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002295">
        <property type="entry name" value="ZFP37 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002134">
        <property type="entry name" value="Zinc finger protein 616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002196">
        <property type="entry name" value="zinc finger protein 850-like isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="84818" checksum="8D92AA47872BA76C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4N8</accession>
    <name>A0A5F8G4N8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch-like protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KLHL20</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the BCR(KLHL20) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL20 and RBX1. Interacts with PDZ-RhoGEF/ARHGEF11, DAPK1, PML and CORO7. Interacts with F-actin. Interacts with IFN-gamma (IFNG). Interacts (via kelch repeats) with IVNS1ABP (via kelch repeats); this interaction blocks the assembly of CUL3-KLHL20 complex.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4N8"/>
    <dbReference type="FunCoup" id="A0A5F8G4N8">
        <property type="interactions" value="2535"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042401"/>
    <dbReference type="Ensembl" id="ENSMODT00000053144.1">
        <property type="protein sequence ID" value="ENSMODP00000042401.1"/>
        <property type="gene ID" value="ENSMODG00000004130.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155161"/>
    <dbReference type="InParanoid" id="A0A5F8G4N8"/>
    <dbReference type="OMA" id="CAVFNNL"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004130">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019964">
        <property type="term" value="F:type II interferon binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990390">
        <property type="term" value="P:protein K33-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18459">
        <property type="entry name" value="BACK_KLHL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18249">
        <property type="entry name" value="BTB_POZ_KLHL20_KLEIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000006">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF451">
        <property type="entry name" value="KELCH-LIKE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023809621" description="Kelch-like protein 20" evidence="7">
        <location>
            <begin position="18"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="92"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="633" mass="70963" checksum="15C8CC80E66764CA" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G501</accession>
    <name>A0A5F8G501_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Disco interacting A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DIP2A</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000069135.1">
        <property type="protein sequence ID" value="ENSMODP00000042568.1"/>
        <property type="gene ID" value="ENSMODG00000008324.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182997"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008324">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000002">
        <property type="entry name" value="Disco interacting protein 2 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF34">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="3">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1447" mass="156629" checksum="F78B3B40A9AACF85" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G502</accession>
    <name>A0A5F8G502_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="34" type="primary">MUSK</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="23">Postsynaptic cell membrane</location>
            <topology evidence="23">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="28">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G502"/>
    <dbReference type="Ensembl" id="ENSMODT00000077378.1">
        <property type="protein sequence ID" value="ENSMODP00000042501.1"/>
        <property type="gene ID" value="ENSMODG00000003983.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158226"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003983">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20970">
        <property type="entry name" value="IgI_1_MuSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20968">
        <property type="entry name" value="IgI_2_MuSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05050">
        <property type="entry name" value="PTKc_Musk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000176">
        <property type="entry name" value="Muscle, skeletal receptor tyrosine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000260">
        <property type="entry name" value="Muscle, skeletal receptor tyrosine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000322">
        <property type="entry name" value="Muscle, skeletal receptor tyrosine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000409">
        <property type="entry name" value="Muscle, skeletal receptor tyrosine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000159">
        <property type="entry name" value="muscle, skeletal receptor tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000009">
        <property type="entry name" value="Muscle, skeletal, receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF317">
        <property type="entry name" value="MUSCLE, SKELETAL RECEPTOR TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 26 29" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="22" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="27" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="9 26 29" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0770">Synapse</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 30" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="33">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="33">
        <location>
            <begin position="116"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="33">
        <location>
            <begin position="207"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="32">
        <location>
            <begin position="304"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="31">
        <location>
            <begin position="562"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="25">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <begin position="569"/>
            <end position="576"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26 29">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <begin position="643"/>
            <end position="649"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="716"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="717"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="856" mass="95469" checksum="74AA5DCD338FDD21" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G503</accession>
    <name>A0A5F8G503_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncoupling protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UCP3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G503"/>
    <dbReference type="FunCoup" id="A0A5F8G503">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000068930.1">
        <property type="protein sequence ID" value="ENSMODP00000042532.1"/>
        <property type="gene ID" value="ENSMODG00000007461.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161030"/>
    <dbReference type="InParanoid" id="A0A5F8G503"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007461">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017077">
        <property type="term" value="F:oxidative phosphorylation uncoupler activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990845">
        <property type="term" value="P:adaptive thermogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901373">
        <property type="term" value="P:lipid hydroperoxide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000303">
        <property type="term" value="P:response to superoxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000008">
        <property type="entry name" value="Mitochondrial uncoupling protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="348" mass="38751" checksum="8D7A249739BCD51C" modified="2019-12-11" version="1">MVGLQPTDVPPTTAVKFVGAGTAACFADLLTFPLDTAKVRLQIQGESQSEKAIQNVRYRGVLGTITTMVKTEGPSSLYNGLVAGLHRQMSFASIRIGLYDSVKQFYTPKGAENSSIIVRILAGCTTGAMAVTCAQPTDVVKVRFQASVRLGPGSCRKYSGTMDAYRTIAREEGIRGLWKGTLPNITRNAIVNCAEMVTYDMIKEALIDRHLMTDNFPCHFISAFSAGFCATVVASPVDVVKTRYINSPPGRYSSTVDCMLKTLSQEGPTAFYKGFTPSFLRFFHRLKHEEMEEEKVLHVPFIATDCNLSLPWEMMFLTFYRQKRIHLLITKPERIPQNNRKYSLKDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G505</accession>
    <name>A0A5F8G505_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="17">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">POLR1A</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the RNA polymerase I (Pol I) complex consisting of 13 subunits: a ten-subunit catalytic core composed of POLR1A/RPA1, POLR1B/RPA2, POLR1C/RPAC1, POLR1D/RPAC2, POLR1H/RPA12, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk subunit POLR1F/RPA43 protruding from the core and additional subunits homologous to general transcription factors POLR1E/RPA49 and POLR1G/RPA34. Part of Pol I pre-initiation complex (PIC), in which Pol I core assembles with RRN3 and promoter-bound UTBF and SL1/TIF-IB complex. Interacts (via dock II domain) with TOP2A; this interaction may assist Pol I transcription initiation by releasing supercoils occurring during DNA unwinding. Interacts with CAVIN1; this interaction induces the dissociation of Pol I complex paused at rDNA terminator sequences. Interacts with MYO1C. Interacts with ERBB2. Interacts with DDX11. Interacts with RECQL5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="17"/>
    <dbReference type="Ensembl" id="ENSMODT00000063427.1">
        <property type="protein sequence ID" value="ENSMODP00000042525.1"/>
        <property type="gene ID" value="ENSMODG00000009335.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00920000149138"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009335">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 17" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="19">
        <location>
            <begin position="296"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1357"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1400"/>
            <end position="1421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1654" mass="185591" checksum="06439F2F681142AB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G506</accession>
    <name>A0A5F8G506_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytoplasmic polyadenylation element binding protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CPEB4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CPEB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G506"/>
    <dbReference type="Ensembl" id="ENSMODT00000082627.1">
        <property type="protein sequence ID" value="ENSMODP00000042573.1"/>
        <property type="gene ID" value="ENSMODG00000006036.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154998"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006036">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12724">
        <property type="entry name" value="RRM1_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12726">
        <property type="entry name" value="RRM2_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000008">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.40:FF:000001">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000009">
        <property type="entry name" value="cytoplasmic polyadenylation element-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF2">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="449"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="557"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="719" mass="79004" checksum="603D19BE92831408" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVP3</accession>
    <name>A0A5F8GVP3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain roadblock</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DYNLRB2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
            <location evidence="1 10">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVP3"/>
    <dbReference type="FunCoup" id="A0A5F8GVP3">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051424"/>
    <dbReference type="Ensembl" id="ENSMODT00000062721.1">
        <property type="protein sequence ID" value="ENSMODP00000051424.1"/>
        <property type="gene ID" value="ENSMODG00000008150.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011067"/>
    <dbReference type="InParanoid" id="A0A5F8GVP3"/>
    <dbReference type="OMA" id="NEIMCAP"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008150">
        <property type="expression patterns" value="Expressed in ovary and 22 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000002">
        <property type="entry name" value="Dynein light chain roadblock"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016561">
        <property type="entry name" value="DYNLRB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009998">
        <property type="entry name" value="DLC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023882718" description="Dynein light chain roadblock" evidence="11">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="12">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="115" mass="13169" checksum="D7543982F933348F" modified="2019-12-11" version="1">MYDRKLFCLTFSMVCIHLLQAEVEETLKRIQNHKGVIGTMVVNAEGIPIRTTLDNSTTVQYAGLLHQLTMKAKSTVRDIDPQNDLTFLRIRSKKHEVMVAPDKEYLLIVIQNPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVP5</accession>
    <name>A0A5F8GVP5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450 3A</fullName>
            <ecNumber evidence="15">1.14.14.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.-" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVP5"/>
    <dbReference type="Ensembl" id="ENSMODT00000062979.1">
        <property type="protein sequence ID" value="ENSMODP00000051271.1"/>
        <property type="gene ID" value="ENSMODG00000000829.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182958"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000829">
        <property type="expression patterns" value="Expressed in liver and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd20650">
        <property type="entry name" value="CYP3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000096">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008072">
        <property type="entry name" value="Cyt_P450_E_CYP3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF38">
        <property type="entry name" value="CYTOCHROME P450 3A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01689">
        <property type="entry name" value="EP450IICYP3A"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="486" mass="55598" checksum="BB561B16F1833741" modified="2019-12-11" version="1">KGLVPSVRLEVLFKNIGIPGPTPFPFIGTILYYRKGIVGFDYGCYKKYGKTWGFFDGTKPVLAIMDPETIKTVLVKECYSVFTNRRVSDSASIMWKKAISIAEDEEWKRIRTVLSPAFTSGKLKEMFPIINQYGDVLVKNMKKEAEKSKPVTMKEIFGAYSMDIIISTSFGIHVDSLNNPNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFSKDATDFLGKSILRIKEERKKSTEKHRVDFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIVFIFAGYESTSSVLSFLFYHLATNLEIQEKLQKEIDAVLPNKEAVTYDALVQMEYLDMVINENLRLYPISGRIERIAKKTVQLNGLTIPQGTVVMTPPYVLHRDPEYWPEPEEFRPERFSKENKESINPYVYLPFGAGPRNCIAMRFALMGMKVAVSRLLQEFSFIPCKETPIPLKLNNQPLLTPSVPIVLQAVLRNKKGNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVP6</accession>
    <name>A0A5F8GVP6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dystrobrevin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">DTNA</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the dystrophin family. Dystrobrevin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVP6"/>
    <dbReference type="Ensembl" id="ENSMODT00000064246.1">
        <property type="protein sequence ID" value="ENSMODP00000051610.1"/>
        <property type="gene ID" value="ENSMODG00000010667.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153897"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010667">
        <property type="expression patterns" value="Expressed in heart and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16249">
        <property type="entry name" value="EFh_DTNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000014">
        <property type="entry name" value="Dystrobrevin alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000016">
        <property type="entry name" value="Dystrobrevin alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000002">
        <property type="entry name" value="Dystrobrevin alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017432">
        <property type="entry name" value="Distrobrevin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF19">
        <property type="entry name" value="DYSTROBREVIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038204">
        <property type="entry name" value="Distrobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="18">
        <location>
            <begin position="245"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="442"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR038204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="716" mass="80835" checksum="D97E00B7025DC1CB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVP7</accession>
    <name>A0A5F8GVP7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylosuccinate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ADSL</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVP7"/>
    <dbReference type="Ensembl" id="ENSMODT00000067877.1">
        <property type="protein sequence ID" value="ENSMODP00000051718.1"/>
        <property type="gene ID" value="ENSMODG00000012930.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183122"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012930">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="132"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="569" mass="62580" checksum="A8EF67D82C4C118E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVP8</accession>
    <name>A0A5F8GVP8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">COPS3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVP8"/>
    <dbReference type="Ensembl" id="ENSMODT00000056872.1">
        <property type="protein sequence ID" value="ENSMODP00000051429.1"/>
        <property type="gene ID" value="ENSMODG00000004742.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153653"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004742">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000354">
        <property type="entry name" value="COP9 signalosome complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000008">
        <property type="entry name" value="COP9 signalosome complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="199"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="396" mass="44921" checksum="CD63F8D696482C80" modified="2019-12-11" version="1">MNMASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILRQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEVNIKMKYSGLVIKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVP9</accession>
    <name>A0A5F8GVP9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ceramide synthase 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100025736</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36548"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVP9"/>
    <dbReference type="Ensembl" id="ENSMODT00000065382.1">
        <property type="protein sequence ID" value="ENSMODP00000051587.1"/>
        <property type="gene ID" value="ENSMODG00000004533.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234515"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004533">
        <property type="expression patterns" value="Expressed in liver and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000020">
        <property type="entry name" value="Ceramide synthase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF6">
        <property type="entry name" value="CERAMIDE SYNTHASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="86"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="297" mass="34816" checksum="7CA8E693197E8849" modified="2019-12-11" version="1">MLATLYESFWKAEYWLPPGYTWADLEDSDDITYPHPKDLLAVVPLTFVLLVIRYGSERIIGLPLSRAMGVRDPRRIKATPNPILESFFQTQNKKPEKDDLSHLASQCSLSVRQIQCWFRRRRNQERPLMSKKFSESCWRFLFYSTSFLDGLFVFYNETWFGKPETVWDGYPKQPLQPAIYWWYLLELSFYFSLLLTLSYDVKRKDFKEQVVHHFVAVTLILFSYSANFVHIGALVLLLHDVSDIFMEVKNDVRSDTEEQDTSDEQLEMRQQKSGKLRSNDAIDIRARGGLKASPACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVQ0</accession>
    <name>A0A5F8GVQ0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 883-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100017222</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVQ0"/>
    <dbReference type="Ensembl" id="ENSMODT00000056456.1">
        <property type="protein sequence ID" value="ENSMODP00000051615.1"/>
        <property type="gene ID" value="ENSMODG00000023737.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153104"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023737">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000008">
        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000053">
        <property type="entry name" value="zinc finger protein 182 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001100">
        <property type="entry name" value="Zinc finger protein 184"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001437">
        <property type="entry name" value="Zinc finger protein 594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001697">
        <property type="entry name" value="zinc finger protein 623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000113">
        <property type="entry name" value="zinc finger protein 699 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="608" mass="70281" checksum="7726BB58CEBC0C17" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVQ3</accession>
    <name>A0A5F8GVQ3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Focadhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FOCAD</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000085924.1">
        <property type="protein sequence ID" value="ENSMODP00000051592.1"/>
        <property type="gene ID" value="ENSMODG00000003634.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004438"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003634">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060147">
        <property type="term" value="P:regulation of post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022542">
        <property type="entry name" value="FOCAD/RST1_DUF3730"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045163">
        <property type="entry name" value="Focadhesin/RST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021392">
        <property type="entry name" value="Focadhesin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16212:SF4">
        <property type="entry name" value="FOCADHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16212">
        <property type="entry name" value="FOCADHESIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12530">
        <property type="entry name" value="DUF3730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11229">
        <property type="entry name" value="Focadhesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3730" evidence="2">
        <location>
            <begin position="491"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Focadhesin C-terminal" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1761"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1761" mass="196261" checksum="09F4C46A6BE843F2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVQ4</accession>
    <name>A0A5F8GVQ4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PAX-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">PAX transactivation activation domain-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PAXIP1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Interacts with the C-terminal transactivation domain of PAX2. Forms a constitutive complex with PAGR1 independently of the MLL2/MLL3 complex. Interacts with TP53BP1 (when phosphorylated at the N-terminus by ATM). Interacts with HLTF. Component of the KMT2 family MLL2/MLL3 complex (also named ASCOM complex), at least composed of the HMTs KMT2D and/or KMT2C, the common subunits ASH2L, RBBP5, WDR5 and DPY30, and the complex type-specific subunits PAXIP1/PTIP, PAGR1, NCOA6 and KDM6A; required for the association of PAGR1 with the MLL2/MLL3 complex. Interacts with NUPR1; this interaction prevents PAXIP1 inhibition of PAX2 transcription factor activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVQ4"/>
    <dbReference type="Ensembl" id="ENSMODT00000083842.1">
        <property type="protein sequence ID" value="ENSMODP00000051620.1"/>
        <property type="gene ID" value="ENSMODG00000004929.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155757"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004929">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17714">
        <property type="entry name" value="BRCT_PAXIP1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17710">
        <property type="entry name" value="BRCT_PAXIP1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17711">
        <property type="entry name" value="BRCT_PAXIP1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17730">
        <property type="entry name" value="BRCT_PAXIP1_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17712">
        <property type="entry name" value="BRCT_PAXIP1_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18440">
        <property type="entry name" value="BRCT_PAXIP1_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000017">
        <property type="entry name" value="PAX interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000043">
        <property type="entry name" value="PAX interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000046">
        <property type="entry name" value="PAX interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="94"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="665"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="755"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="901"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="184"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="451"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="585"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1107" mass="126746" checksum="CFCE4EFF6E17408B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVQ6</accession>
    <name>A0A5F8GVQ6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Smaug homolog 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sterile alpha motif domain-containing protein 4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SAMD4A</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Synapse</location>
            <location evidence="10">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMAUG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001370431.1">
        <property type="nucleotide sequence ID" value="XM_001370394.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056666947.1">
        <property type="nucleotide sequence ID" value="XM_056810969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVQ6"/>
    <dbReference type="Ensembl" id="ENSMODT00000064256.1">
        <property type="protein sequence ID" value="ENSMODP00000051728.1"/>
        <property type="gene ID" value="ENSMODG00000011669.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100024135"/>
    <dbReference type="CTD" id="23034"/>
    <dbReference type="GeneTree" id="ENSGT00940000157933"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011669">
        <property type="expression patterns" value="Expressed in spermatid and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030371">
        <property type="term" value="F:translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09557">
        <property type="entry name" value="SAM_Smaug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000013">
        <property type="entry name" value="Protein Smaug homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.170:FF:000001">
        <property type="entry name" value="Protein Smaug homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.170:FF:000002">
        <property type="entry name" value="Protein Smaug homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.170">
        <property type="entry name" value="Smaug, PHAT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037093">
        <property type="entry name" value="PHAT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058599">
        <property type="entry name" value="PHAT_Smg/ZCCHC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037634">
        <property type="entry name" value="Smaug_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF8">
        <property type="entry name" value="PROTEIN SMAUG HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26034">
        <property type="entry name" value="PHAT_SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="6" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="233"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="473"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="619" mass="69241" checksum="0ABA8C2AEC8F097A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVQ7</accession>
    <name>A0A5F8GVQ7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tumor protein D52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TPD52</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPD52 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVQ7"/>
    <dbReference type="Ensembl" id="ENSMODT00000060977.1">
        <property type="protein sequence ID" value="ENSMODP00000051597.1"/>
        <property type="gene ID" value="ENSMODG00000006613.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155294"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006613">
        <property type="expression patterns" value="Expressed in endometrium and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007327">
        <property type="entry name" value="TPD52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307:SF12">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04201">
        <property type="entry name" value="TPD52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="202" mass="22805" checksum="D9111B15152374BB" modified="2019-12-11" version="1">MERGLLKTDQVPEEGEDAVATISATETLSEEEQEELRKELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELRQNIARGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKNSPTFKSFEEKVENLKVKVMMVYIFVVFGWCLDFSSLCKSFSSVFLGIYIYHVYLYLCIYIYHGILLGVDSREIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVQ8</accession>
    <name>A0A5F8GVQ8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GATA zinc finger domain containing 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GATAD2A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007489266.1">
        <property type="nucleotide sequence ID" value="XM_007489204.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056678348.1">
        <property type="nucleotide sequence ID" value="XM_056822370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVQ8"/>
    <dbReference type="Ensembl" id="ENSMODT00000072065.1">
        <property type="protein sequence ID" value="ENSMODP00000051625.1"/>
        <property type="gene ID" value="ENSMODG00000007189.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100010942"/>
    <dbReference type="CTD" id="54815"/>
    <dbReference type="GeneTree" id="ENSGT00390000004097"/>
    <dbReference type="OrthoDB" id="8186989at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007189">
        <property type="expression patterns" value="Expressed in spermatid and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040386">
        <property type="entry name" value="P66"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032346">
        <property type="entry name" value="P66_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR P66-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR P66-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16563">
        <property type="entry name" value="P66_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="601" mass="65268" checksum="E1B8909E91A978F1" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVR0</accession>
    <name>A0A5F8GVR0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Radial spoke head protein 9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RSPH9</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell projection</location>
            <location evidence="8">Kinocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the flagellar radial spoke RSP9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVR0"/>
    <dbReference type="Ensembl" id="ENSMODT00000070578.1">
        <property type="protein sequence ID" value="ENSMODP00000051733.1"/>
        <property type="gene ID" value="ENSMODG00000018954.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018686"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018954">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060091">
        <property type="term" value="C:kinocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055316">
        <property type="entry name" value="RSP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="284" mass="32134" checksum="D135E703E1FA042D" modified="2019-12-11" version="1">MDSESLLLSLELASGSGQGLSPDRRASLLTSLLLVKRDYRYDRVLFWGRILGLVADYYIAQGLGPDQLGERKSLYSLNCMEWSLLPPATEEMVTQTSVVKGRFMGDPSHEYEHVEMQRMTEGDRTYEDEVVIQIKEESRLVSVIDQIDKAVAIIPRGAFFKTPFGPVHVNRTFEGLTLADAKKLTSYFHFTEPIELKNKSLLEKADLDPSLDFLDNLEHDIPKGSWSVQMERGNALVVLRSLLWPGLTFFHAPRTKNHGYIYVGTVAYFPSRLLVFEIATGDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVR2</accession>
    <name>A0A5F8GVR2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Muscleblind like splicing regulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MBNL2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the muscleblind family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVR2"/>
    <dbReference type="Ensembl" id="ENSMODT00000076367.1">
        <property type="protein sequence ID" value="ENSMODP00000051630.1"/>
        <property type="gene ID" value="ENSMODG00000008566.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182897"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008566">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000004">
        <property type="entry name" value="Muscleblind like splicing regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000002">
        <property type="entry name" value="Muscleblind-like 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF4">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="340" mass="36955" checksum="915AA0ED9487ACE0" modified="2019-12-11" version="1">MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHPVPTFPVGPALGTNAAISFAPYLTPVTPGVGLVPTEILPTTPVIVPGSPPVTVPGSAATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPSDSTMIDTNDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMTQSTAKAMKRPLEATVDLAFPPGALHPLPKRQALEKSNGASAVFNPSVLHYQQALANAQLQQHTAFIPTAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVR3</accession>
    <name>A0A5F8GVR3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease A-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the pancreatic ribonuclease family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVR3"/>
    <dbReference type="Ensembl" id="ENSMODT00000056443.1">
        <property type="protein sequence ID" value="ENSMODP00000051449.1"/>
        <property type="gene ID" value="ENSMODG00000006948.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160869"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006948">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06265">
        <property type="entry name" value="RNase_A_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.130.10:FF:000001">
        <property type="entry name" value="Ribonuclease pancreatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.130.10">
        <property type="entry name" value="Ribonuclease A-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001427">
        <property type="entry name" value="RNaseA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036816">
        <property type="entry name" value="RNaseA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023411">
        <property type="entry name" value="RNaseA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023412">
        <property type="entry name" value="RNaseA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437:SF24">
        <property type="entry name" value="RIBONUCLEASE PANCREATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00074">
        <property type="entry name" value="RnaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00794">
        <property type="entry name" value="RIBONUCLEASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00092">
        <property type="entry name" value="RNAse_Pc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54076">
        <property type="entry name" value="RNase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00127">
        <property type="entry name" value="RNASE_PANCREATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023825439" description="Ribonuclease A-domain domain-containing protein" evidence="10">
        <location>
            <begin position="38"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease A-domain" evidence="11">
        <location>
            <begin position="38"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="161" mass="18064" checksum="C1DA207436A92D0F" modified="2019-12-11" version="1">MLPCAKMSEATMALKGSHLMLLLLGLFLAELVHQSTGKESPSKKFQRQHMDPENSASDDTKYCDHMMKARNMTKGRCKPVNTFIHEPKEIVDAVCRETNITCKNGQSNCYQSSQPMSLTHCRQTGASKYPNCQYRGSDITKQIIVACEGNPYVPVHFDAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVR6</accession>
    <name>A0A5F8GVR6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TAP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TAPBP</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVR6"/>
    <dbReference type="Ensembl" id="ENSMODT00000052439.1">
        <property type="protein sequence ID" value="ENSMODP00000051635.1"/>
        <property type="gene ID" value="ENSMODG00000014159.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159200"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014159">
        <property type="expression patterns" value="Expressed in lung and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023825256" evidence="2">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="195"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="347" mass="37234" checksum="AE10B95A2469DA3E" modified="2019-12-11" version="1">MKPLCLLLALGILAVRWSDARPGPSKLECWFVEEQGGGGGMLRGVTKRPAMLLLRQGPGEPPPRPDLDPSLYLKVLHPLSAICVRFTIGPLNSGRALSSLGPPPFGLEWRRQHRGTGQLLLAVTPGLGSQALGSPEGAVAFATWDEEGVEGPWNGNGTLLLPAVQLSQEGTYLATVHLPHLQAQVALELKVQKPPKVTLSPSPIVWAYPGQAPPELLCLISHFYPPEELNVTWEFHSSIGERSKVAGGQAWCSSYRYHPDGMVSISAYLRPPSVKVEQHGSHYVCRVHHPSLQAKSISAQVSLEVAGVSGPSLEDGVGLFLSAFLLLGLIKGIGWIGKHLSACLAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW02</accession>
    <name>A0A5F8GW02_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cysteine and serine rich nuclear protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CSRNP3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007494355.1">
        <property type="nucleotide sequence ID" value="XM_007494293.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW02"/>
    <dbReference type="Ensembl" id="ENSMODT00000060387.1">
        <property type="protein sequence ID" value="ENSMODP00000051346.1"/>
        <property type="gene ID" value="ENSMODG00000006452.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100016453"/>
    <dbReference type="KEGG" id="mdo:100016453"/>
    <dbReference type="CTD" id="80034"/>
    <dbReference type="GeneTree" id="ENSGT00950000183072"/>
    <dbReference type="OrthoDB" id="5946974at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006452">
        <property type="expression patterns" value="Expressed in testis and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF13">
        <property type="entry name" value="CYSTEINE_SERINE-RICH NUCLEAR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02031">
        <property type="entry name" value="CYSSERRICHNP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="88"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="609" mass="68146" checksum="4C69480402AE3929" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW03</accession>
    <name>A0A5F8GW03_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Astrotactin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ASTN1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW03"/>
    <dbReference type="Ensembl" id="ENSMODT00000071419.1">
        <property type="protein sequence ID" value="ENSMODP00000051833.1"/>
        <property type="gene ID" value="ENSMODG00000005711.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003140"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005711">
        <property type="expression patterns" value="Expressed in cerebellum and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040685">
        <property type="entry name" value="Annexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045574">
        <property type="entry name" value="ASTN1_2_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045575">
        <property type="entry name" value="ASTN_1_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026995">
        <property type="entry name" value="Astrotactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16592:SF8">
        <property type="entry name" value="ASTROTACTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16592">
        <property type="entry name" value="ASTROTACTIN-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18411">
        <property type="entry name" value="Annexin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19743">
        <property type="entry name" value="ASTN1_2_fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19441">
        <property type="entry name" value="ASTN_1_2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023867413" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="470"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="586"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="634"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="6">
        <location>
            <begin position="786"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1277" mass="141844" checksum="9AC60C7B64253BF4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW04</accession>
    <name>A0A5F8GW04_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin repeat and SOCS box protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ASB2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056666482.1">
        <property type="nucleotide sequence ID" value="XM_056810504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW04"/>
    <dbReference type="Ensembl" id="ENSMODT00000061474.1">
        <property type="protein sequence ID" value="ENSMODP00000051549.1"/>
        <property type="gene ID" value="ENSMODG00000002296.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100014676"/>
    <dbReference type="CTD" id="51676"/>
    <dbReference type="GeneTree" id="ENSGT00940000155490"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002296">
        <property type="expression patterns" value="Expressed in heart and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055007">
        <property type="term" value="P:cardiac muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03721">
        <property type="entry name" value="SOCS_ASB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000246">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000254">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037330">
        <property type="entry name" value="ASB2_SOCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF190">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 12, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="11">
        <location>
            <begin position="588"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="637" mass="70860" checksum="2DAD802645750971" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW06</accession>
    <name>A0A5F8GW06_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Insulin like growth factor 2 mRNA binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">IGF2BP2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW06"/>
    <dbReference type="Ensembl" id="ENSMODT00000059511.1">
        <property type="protein sequence ID" value="ENSMODP00000051351.1"/>
        <property type="gene ID" value="ENSMODG00000002822.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154913"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002822">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22500">
        <property type="entry name" value="KH-I_IGF2BP2_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="84"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="214"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="310" mass="33756" checksum="494C76790C9D3BFC" modified="2019-12-11" version="1">MRKLREAYENDMLTVNQQGSLIPGLNLSALGIFSTGLSMLPSAAGPRGAAAASYNPFASHSAYLSGLYGAPQIGVFPHQHPVPEQEVVYLFIPTQAVGAIIGKKGHHIKQLARFARASIKTLLRYRPLCETFPGPGLPASPKVLGLNPLLFSLFMYPLGVFPLECELPIAPAEGPDVGERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLKAHIRVPSSAAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVKIIGHFFASQTAQRKIREIVQQVNQQEQKHPQGAALPLPPQQRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW07</accession>
    <name>A0A5F8GW07_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl peptidase 1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW07"/>
    <dbReference type="Ensembl" id="ENSMODT00000085772.1">
        <property type="protein sequence ID" value="ENSMODP00000051838.1"/>
        <property type="gene ID" value="ENSMODG00000044360.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155787"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000044360">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.80">
        <property type="entry name" value="Cathepsin C, exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014882">
        <property type="entry name" value="CathepsinC_exc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036496">
        <property type="entry name" value="CathepsinC_exc_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08773">
        <property type="entry name" value="CathepsinC_exc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75001">
        <property type="entry name" value="Dipeptidyl peptidase I (cathepsin C), exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023944493" evidence="1">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin C exclusion" evidence="2">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="131" mass="14667" checksum="DA3FECAC8BE4FF0E" modified="2019-12-11" version="1">MGLCGYSLLPVLLFLLSGVHDASSDTPANCTFDDLQGTWVFQVSEGRGPNDNRIDCSKPGPPKDKMVVHLQKLNVAQDDFGNSGIFTIIYNQGFEVVINDYKWFAFFKDVTDFMSQYFLHVGTVGKYDLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW08</accession>
    <name>A0A5F8GW08_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tuberin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TSC2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1. Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Lysosome membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007499442.1">
        <property type="nucleotide sequence ID" value="XM_007499380.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000070548.1">
        <property type="protein sequence ID" value="ENSMODP00000051554.1"/>
        <property type="gene ID" value="ENSMODG00000016014.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100011431"/>
    <dbReference type="CTD" id="7249"/>
    <dbReference type="GeneTree" id="ENSGT00950000183139"/>
    <dbReference type="OrthoDB" id="5797019at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016014">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000004">
        <property type="entry name" value="Tuberin isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003913">
        <property type="entry name" value="Tuberin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01431">
        <property type="entry name" value="TUBERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Rap-GAP" evidence="12">
        <location>
            <begin position="1509"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="930"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1099"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1345"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1377"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1739"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="935"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1044"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1105"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1316"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1349"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1377"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1425"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1751"/>
            <end position="1764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1787" mass="200095" checksum="96BD0523937D6497" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW10</accession>
    <name>A0A5F8GW10_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Eukaryotic elongation factor 2 kinase</fullName>
            <ecNumber evidence="13 15">2.7.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">EEF2K</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21436"/>
            <dbReference type="Rhea" id="RHEA-COMP:11268"/>
            <dbReference type="Rhea" id="RHEA-COMP:11269"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.20"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer or homodimer. Interacts with Calmodulin/CALM1; this interaction is strictly required for phosphorylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 15">Belongs to the protein kinase superfamily. Alpha-type protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.20" evidence="13 15"/>
    <dbReference type="RefSeq" id="XP_007498303.1">
        <property type="nucleotide sequence ID" value="XM_007498241.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW10"/>
    <dbReference type="Ensembl" id="ENSMODT00000075720.1">
        <property type="protein sequence ID" value="ENSMODP00000051356.1"/>
        <property type="gene ID" value="ENSMODG00000007732.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100019979"/>
    <dbReference type="CTD" id="29904"/>
    <dbReference type="GeneTree" id="ENSGT00940000157839"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007732">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004686">
        <property type="term" value="F:elongation factor-2 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16967">
        <property type="entry name" value="Alpha_kinase_eEF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000229">
        <property type="entry name" value="Eukaryotic elongation factor 2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.200.10:FF:000002">
        <property type="entry name" value="Eukaryotic elongation factor 2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000230">
        <property type="entry name" value="Eukaryotic elongation factor 2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000336">
        <property type="entry name" value="Eukaryotic elongation factor 2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017400">
        <property type="entry name" value="eEF-2K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047588">
        <property type="entry name" value="eEF2K_a_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038139">
        <property type="entry name" value="Elongation_factor_2_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 15" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="17">
        <location>
            <begin position="116"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="351"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="416"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR038139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="679" mass="77429" checksum="7845BA889F4B164E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW11</accession>
    <name>A0A5F8GW11_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW11"/>
    <dbReference type="Ensembl" id="ENSMODT00000061455.1">
        <property type="protein sequence ID" value="ENSMODP00000051843.1"/>
        <property type="gene ID" value="ENSMODG00000050187.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000050187">
        <property type="expression patterns" value="Expressed in spermatid and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="16"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="105"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="192"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="281"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="368"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="457"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="544"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="633"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="720"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="809"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="896"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109644" checksum="88307C25E278CB89" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW13</accession>
    <name>A0A5F8GW13_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ASZ1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW13"/>
    <dbReference type="Ensembl" id="ENSMODT00000078043.1">
        <property type="protein sequence ID" value="ENSMODP00000051745.1"/>
        <property type="gene ID" value="ENSMODG00000015784.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00880000138051"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015784">
        <property type="expression patterns" value="Expressed in testis and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09521">
        <property type="entry name" value="SAM_ASZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000060">
        <property type="entry name" value="Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042650">
        <property type="entry name" value="Asz1_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157:SF3">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="9" id="KW-0744">Spermatogenesis</keyword>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="16">
        <location>
            <begin position="232"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="434" mass="48294" checksum="986BDA0E1230E7C4" modified="2019-12-11" version="1">MAGSLGSLVVAGGGESSDSEEDYWDIGYMDRAPQTMKGSSVTEEKDETFKKALTSGDISLVEELLNSDQYTILMAACSARASEGQILKSVELLLSRNANPNVACRKCMTPIMYAAREGHPQVVALLVAHGAEINAQDENGYTALMWAARQGHKSVVLKLLELGANKTIQTKDGKTAGEIAKRNKHPELFTLLSLTVNPLQGKLQHLTKEEAICRLLTTDGDTGKDHKFSSYTAFGDLELFLHGLGLEHMTELLKEREITLRQLLTMRKEDFTENGITNIRDQQKILDAVKELQVEEIKFGELTEVINLEISGDEFLNFLLKLNKQCGHLTTAVQNIINQLPVNSHKIVLEWGSSQRFTSVCENLVGNVEDLGEEVCKLKDLIQKLQNDQKNDPCRVPPIETFSTWNSRFLKRATFTVCGFGFLLFICKLTLQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW15</accession>
    <name>A0A5F8GW15_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">SLIT-ROBO Rho GTPase-activating protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW15"/>
    <dbReference type="Ensembl" id="ENSMODT00000057624.1">
        <property type="protein sequence ID" value="ENSMODP00000051848.1"/>
        <property type="gene ID" value="ENSMODG00000001993.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182824"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001993">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07682">
        <property type="entry name" value="F-BAR_srGAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04383">
        <property type="entry name" value="RhoGAP_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11955">
        <property type="entry name" value="SH3_srGAP1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000010">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000006">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000266">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035648">
        <property type="entry name" value="srGAP1/2/3_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12 22 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="F-BAR" evidence="27">
        <location>
            <begin position="22"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="26">
        <location>
            <begin position="486"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="25">
        <location>
            <begin position="729"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="852"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="921"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1008" mass="114127" checksum="51CBDCF69EE688D6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW16</accession>
    <name>A0A5F8GW16_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SPCS2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3. Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3. Within the complex, interacts with SEC11A or SEC11C and SPCS1. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW16"/>
    <dbReference type="Ensembl" id="ENSMODT00000087451.1">
        <property type="protein sequence ID" value="ENSMODP00000051564.1"/>
        <property type="gene ID" value="ENSMODG00000042403.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000038181"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000042403">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="228" mass="26147" checksum="BC559112FE08D5DE" modified="2019-12-11" version="1">SSIEKSLGFKRLQRQLGASVDREQIQRWKDSAYQPCKGGNWKIDDKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLIICTISCFFAVVALIWDYLHPFPASKPVLALCVISYFIMMGILTIYTSYKEKSIFLVAHRKDPSGMDPDDVWQLSSSLKRFDDKYTLKLTFISGKTKQQREAEFTKSIAKFFDNSGMLVMEAYEPEISKLHDSLATERKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW17</accession>
    <name>A0A5F8GW17_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ER membrane associated RNA degradation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ERMARD</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW17"/>
    <dbReference type="Ensembl" id="ENSMODT00000071299.1">
        <property type="protein sequence ID" value="ENSMODP00000051750.1"/>
        <property type="gene ID" value="ENSMODG00000005645.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001024"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005645">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025209">
        <property type="entry name" value="DUF4209"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039635">
        <property type="entry name" value="ERMARD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701:SF2">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13910">
        <property type="entry name" value="DUF4209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4209" evidence="2">
        <location>
            <begin position="142"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="632" mass="72981" checksum="65DC320E6A8F1D0D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW18</accession>
    <name>A0A5F8GW18_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Neurotrimin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NTM</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the immunoglobulin superfamily. IgLON family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW18"/>
    <dbReference type="Ensembl" id="ENSMODT00000053881.1">
        <property type="protein sequence ID" value="ENSMODP00000051569.1"/>
        <property type="gene ID" value="ENSMODG00000005322.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158679"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005322">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000013">
        <property type="entry name" value="cell adhesion molecule 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000305">
        <property type="entry name" value="neurotrimin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000113">
        <property type="entry name" value="Opioid-binding protein/cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050876">
        <property type="entry name" value="IgLON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42757">
        <property type="entry name" value="IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42757:SF9">
        <property type="entry name" value="NEUROTRIMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="41"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="137"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="223"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="356" mass="39376" checksum="7A30B1A475D56A1B" modified="2019-12-11" version="1">MDNVTVRQGESATLSLTPAYGTVTSSEDRCIEEPAQHASNPTVYHNSFERIPGGQEKCTVDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLTNTKTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIIEISSDISINEGSNISLTCIATGRPEPTVTWRHISPTAVGFMSEDEYLEIQGITRAQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKSTGVAVGQKGTLQCEASAVPSAEFQWYKDDKRLVGGQKRVKVENRPFLSKLIFFNVSEHDYGNYTCVASNNLGHTNASITLFEEKTTVMTPWKAPGAVSEVNNGTSRRAGCIWLLPLLILHLLLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW19</accession>
    <name>A0A5F8GW19_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TMTC1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMTC family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW19"/>
    <dbReference type="Ensembl" id="ENSMODT00000055482.1">
        <property type="protein sequence ID" value="ENSMODP00000051366.1"/>
        <property type="gene ID" value="ENSMODG00000014377.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158027"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014377">
        <property type="expression patterns" value="Expressed in cerebellum and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052943">
        <property type="entry name" value="TMTC_O-mannosyl-trnsfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="17">
        <location>
            <begin position="357"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="582"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="613"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="647"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="681"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="748"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="847"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="880"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="910" mass="102236" checksum="C7C1A2A5E02CEA87" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW21</accession>
    <name>A0A5F8GW21_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000063959.1">
        <property type="protein sequence ID" value="ENSMODP00000051687.1"/>
        <property type="gene ID" value="ENSMODG00000041553.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162673"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000041553">
        <property type="expression patterns" value="Expressed in liver and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000436">
        <property type="entry name" value="ATP binding cassette subfamily A member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF274">
        <property type="entry name" value="ABC-TYPE ORGANIC ANION TRANSPORTER ABCA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="814"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="980"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="437"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1149"/>
            <end position="1386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1489" mass="169456" checksum="9B734C77E263AA0D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW22</accession>
    <name>A0A5F8GW22_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FBXO15</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007487847.1">
        <property type="nucleotide sequence ID" value="XM_007487785.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW22"/>
    <dbReference type="FunCoup" id="A0A5F8GW22">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051755"/>
    <dbReference type="Ensembl" id="ENSMODT00000086882.1">
        <property type="protein sequence ID" value="ENSMODP00000051755.1"/>
        <property type="gene ID" value="ENSMODG00000012399.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021362"/>
    <dbReference type="CTD" id="201456"/>
    <dbReference type="GeneTree" id="ENSGT00390000017498"/>
    <dbReference type="InParanoid" id="A0A5F8GW22"/>
    <dbReference type="OMA" id="YIMEHID"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012399">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22093">
        <property type="entry name" value="F-box_FBXO15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46731">
        <property type="entry name" value="F-BOX ONLY PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46731:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="526" mass="60137" checksum="622A0C27A2ECDD25" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW24</accession>
    <name>A0A5F8GW24_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TMTC1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMTC family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="5"/>
    <dbReference type="RefSeq" id="XP_056653649.1">
        <property type="nucleotide sequence ID" value="XM_056797671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW24"/>
    <dbReference type="Ensembl" id="ENSMODT00000058826.1">
        <property type="protein sequence ID" value="ENSMODP00000051371.1"/>
        <property type="gene ID" value="ENSMODG00000014377.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100020399"/>
    <dbReference type="CTD" id="83857"/>
    <dbReference type="GeneTree" id="ENSGT00940000158027"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014377">
        <property type="expression patterns" value="Expressed in cerebellum and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052943">
        <property type="entry name" value="TMTC_O-mannosyl-trnsfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="17">
        <location>
            <begin position="290"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="580"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="614"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="681"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="749"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="787"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="821"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="854"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="884" mass="99579" checksum="8160C6B28028BA1B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW26</accession>
    <name>A0A5F8GW26_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroplakin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">UPK2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_001380648.3">
        <property type="nucleotide sequence ID" value="XM_001380611.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW26"/>
    <dbReference type="Ensembl" id="ENSMODT00000054636.1">
        <property type="protein sequence ID" value="ENSMODP00000051858.1"/>
        <property type="gene ID" value="ENSMODG00000013355.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100031362"/>
    <dbReference type="KEGG" id="mdo:100031362"/>
    <dbReference type="CTD" id="7379"/>
    <dbReference type="GeneTree" id="ENSGT00390000006115"/>
    <dbReference type="OMA" id="SFMVPPC"/>
    <dbReference type="OrthoDB" id="9947134at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013355">
        <property type="expression patterns" value="Expressed in placenta and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009952">
        <property type="entry name" value="Uroplakin-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17573">
        <property type="entry name" value="UROPLAKIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17573:SF0">
        <property type="entry name" value="UROPLAKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07353">
        <property type="entry name" value="Uroplakin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023879271" evidence="2">
        <location>
            <begin position="39"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="197" mass="21140" checksum="697814D3762F5E07" modified="2019-12-11" version="1">MPQGQTRHLRRLPDPSPIAMSFLMPTLLLLVLPHLGSAEFNISSLSGLLSPALAESLLVALPPCHLTGGKASLTVRRVNESAGMTHNFTVPPCRARRDLVSVVYNSGSFSITRLSAYQVTNLIPGTKYFVYYSVEKGTAVESSNKVQMATLPRRKVETLGLGMARTGGMIVITVLLSVAMFLLVVGLIVALALGVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW29</accession>
    <name>A0A5F8GW29_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exosome component 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EXOSC1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW29"/>
    <dbReference type="Ensembl" id="ENSMODT00000073942.1">
        <property type="protein sequence ID" value="ENSMODP00000051697.1"/>
        <property type="gene ID" value="ENSMODG00000004213.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015287"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004213">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000024">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="168" mass="18360" checksum="C3910498369FE52B" modified="2019-12-11" version="1">MAPPLKYCVPGERLCNVEEASPGSGTYTRHGYIFSSLSGCLVKTSDNGELPVVSVTRETESQLLPDVGTIVTCKVSSINSRFAKVHILYVGSTPLKNSFRGTIRKEDVRATEKDKVSRWCQSAGVRCSALGRTLKNSARLPEYSQSSCRRSSFTLLHVGGILFSTIHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW30</accession>
    <name>A0A5F8GW30_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM/homeobox protein Lhx9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LHX9</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW30"/>
    <dbReference type="Ensembl" id="ENSMODT00000080757.1">
        <property type="protein sequence ID" value="ENSMODP00000051376.1"/>
        <property type="gene ID" value="ENSMODG00000012746.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158821"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012746">
        <property type="expression patterns" value="Expressed in hindlimb bud and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09469">
        <property type="entry name" value="LIM1_Lhx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09377">
        <property type="entry name" value="LIM2_Lhx2_Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000039">
        <property type="entry name" value="LIM/homeobox protein Lhx9 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000033">
        <property type="entry name" value="LIM/homeobox protein Lhx9 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF95">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN LHX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="60"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="256"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="258"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="321" mass="36194" checksum="6E2660B591199DFC" modified="2019-12-11" version="1">MLNGTTLEAAMLFHGISGGHIQGIMEEMERRSKTESRLAKGGQMNGREASMPPMSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARESVYHLSCFTCTTCNKTLTTGDHFGMKDNLVYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIVNYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQGEQILGHYSQTSRRLKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW33</accession>
    <name>A0A5F8GW33_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UEV and lactate/malate dehyrogenase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">UEVLD</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW33"/>
    <dbReference type="Ensembl" id="ENSMODT00000065426.1">
        <property type="protein sequence ID" value="ENSMODP00000051584.1"/>
        <property type="gene ID" value="ENSMODG00000006389.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164122"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006389">
        <property type="expression patterns" value="Expressed in endometrium and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF33">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UEV" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="337" mass="37351" checksum="487721BA95C25435" modified="2019-12-11" version="1">MDTYVFKDSSQKDLLNFTGTIPVNYQGNTYNIPIRFWILDSHPFAPPICFLKPTANMGISVGKHVDAQGRIYLPYLQNWSHPKSIITGLISEMIIKFQEELPLYSLSSAAETQQVELLAYISKITQGISDMNSKNQEKSVNKITVVGSGELGIACVLAILAKGVADKVVLIDFSEGTKGGAMDIDIFELQNVEISKDLSASWNSKVVIFTVNSLGNSHTYLDVVQNNVDMFKELVPALGHYSPQSVILVASQPVEIMTYAAWKLSAFPENQVIGIGCNLDSKRFQYILTNVLKAQSSGNEMWIIGEQGEDKVPTWSNQEEAVAPDFWVQMSNRDIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW34</accession>
    <name>A0A5F8GW34_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SH3 domain-binding glutamic acid-rich-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SH3BGRL</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Interacts with PFN1/Profilin-1. Interacts with ERBB2. Interacts with ATG12. Interacts with BECN1. Interacts with translating ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SH3BGR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056665241.1">
        <property type="nucleotide sequence ID" value="XM_056809263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW34"/>
    <dbReference type="FunCoup" id="A0A5F8GW34">
        <property type="interactions" value="1071"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051702"/>
    <dbReference type="Ensembl" id="ENSMODT00000067064.1">
        <property type="protein sequence ID" value="ENSMODP00000051702.1"/>
        <property type="gene ID" value="ENSMODG00000004322.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021552"/>
    <dbReference type="CTD" id="6451"/>
    <dbReference type="GeneTree" id="ENSGT00940000156017"/>
    <dbReference type="InParanoid" id="A0A5F8GW34"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004322">
        <property type="expression patterns" value="Expressed in lung and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140517">
        <property type="term" value="F:protein-RNA adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904690">
        <property type="term" value="P:positive regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03030">
        <property type="entry name" value="GRX_SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF5">
        <property type="entry name" value="ADAPTER SH3BGRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008142">
        <property type="entry name" value="SH3-bind_E-rich_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0729">SH3-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="115" mass="12902" checksum="D50DB1339A657594" modified="2019-12-11" version="1">MAIGKNKLFSSAHSTRIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPEESRPATGNPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAQALAKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW37</accession>
    <name>A0A5F8GW37_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myocyte enhancer factor 2D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MEF2D</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW37"/>
    <dbReference type="Ensembl" id="ENSMODT00000080980.1">
        <property type="protein sequence ID" value="ENSMODP00000051770.1"/>
        <property type="gene ID" value="ENSMODG00000016861.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159463"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016861">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022102">
        <property type="entry name" value="HJURP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF23">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12347">
        <property type="entry name" value="HJURP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="140" mass="16346" checksum="0B8C1BD89C1293E1" modified="2019-12-11" version="1">MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYASTDMDKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGEDSLEQSPLLEDKYRPASEELDGLFRRYGGPCWEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7P1</accession>
    <name>A0A5F8H7P1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ral transcription factor IIIC subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GTF3C1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000054193.1">
        <property type="protein sequence ID" value="ENSMODP00000055221.1"/>
        <property type="gene ID" value="ENSMODG00000015484.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008664"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015484">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056428">
        <property type="entry name" value="WH_GTF3C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23704">
        <property type="entry name" value="WHD_GTF3C1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="General transcription factor 3C polypeptide 1 winged-helix" evidence="8">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="174"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="9">
        <location>
            <begin position="612"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="721"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="825"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1163"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1576"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1787"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1163"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1182"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1210"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1582"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1808"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1853"/>
            <end position="1869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2056" mass="234830" checksum="7A3C612A6D445F16" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7P3</accession>
    <name>A0A5F8H7P3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Histone acetyltransferase</fullName>
            <ecNumber evidence="25">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">KAT7</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 25">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="25"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7P3"/>
    <dbReference type="Ensembl" id="ENSMODT00000084537.1">
        <property type="protein sequence ID" value="ENSMODP00000055980.1"/>
        <property type="gene ID" value="ENSMODG00000012142.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157744"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012142">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036409">
        <property type="term" value="C:histone H3-K14 acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036408">
        <property type="term" value="F:histone H3K14 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902035">
        <property type="term" value="P:positive regulation of hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045935">
        <property type="term" value="P:positive regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000092">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="21" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="22" id="KW-0137">Centromere</keyword>
    <keyword evidence="15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20 25" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="17" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="27">
        <location>
            <begin position="305"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="23">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="584" mass="67158" checksum="226C4B4571E40350" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7Q4</accession>
    <name>A0A5F8H7Q4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calmin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CLMN</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7Q4"/>
    <dbReference type="Ensembl" id="ENSMODT00000086525.1">
        <property type="protein sequence ID" value="ENSMODP00000055236.1"/>
        <property type="gene ID" value="ENSMODG00000012630.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159056"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012630">
        <property type="expression patterns" value="Expressed in spermatid and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21245">
        <property type="entry name" value="CH_CLMN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000057">
        <property type="entry name" value="Calmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047826">
        <property type="entry name" value="CLMN_CH_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052403">
        <property type="entry name" value="LINC-complex_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535:SF7">
        <property type="entry name" value="CALMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="947"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="159"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="725"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="770"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="972" mass="108468" checksum="1FA3F32F5C38FEDE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7Q5</accession>
    <name>A0A5F8H7Q5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7Q5"/>
    <dbReference type="Ensembl" id="ENSMODT00000068492.1">
        <property type="protein sequence ID" value="ENSMODP00000055990.1"/>
        <property type="gene ID" value="ENSMODG00000025533.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161846"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025533">
        <property type="expression patterns" value="Expressed in spermatid and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000016">
        <property type="entry name" value="B-cell linker protein isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051751">
        <property type="entry name" value="Immunoreceptor_sig_adapters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14098:SF2">
        <property type="entry name" value="CYTOKINE-DEPENDENT HEMATOPOIETIC CELL LINKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14098">
        <property type="entry name" value="SH2 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="143"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="270" mass="30457" checksum="1D095F532B5D3684" modified="2019-12-11" version="1">MDSLIFCQCFNTVFRCCFSGESEIKGIKNPLPPPRPPNTLPKKYRPLPPEPENRLTLNQRNDLLEADKSTRQISLKDLSDVLQGDKVPDHLKKPIIPCQTQHHLKDLSVPVASSLLMMADPSFQGKGHKVSMSSPSLQKASQPAHGNLLDDKPLPTSLLQKKPYHGKCSKKDGTFLVRDSSKKSMAEPYVLVVFHRNKVYNVKIRFLEGSQQFALGTGLRGDDKFDSVEDIIEYYKLFPIVLIDGKDQTGTHREHCYLKKPLSLSRIYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7Q6</accession>
    <name>A0A5F8H7Q6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7Q6"/>
    <dbReference type="Ensembl" id="ENSMODT00000082511.1">
        <property type="protein sequence ID" value="ENSMODP00000055847.1"/>
        <property type="gene ID" value="ENSMODG00000048439.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158281"/>
    <dbReference type="OMA" id="HECEQCE"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000048439">
        <property type="expression patterns" value="Expressed in testis and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000101">
        <property type="entry name" value="Transient receptor potential cation channel subfamily V member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008347">
        <property type="entry name" value="TrpV1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF6">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01768">
        <property type="entry name" value="TRPVRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="453" mass="50173" checksum="32B1D6110A911A50" modified="2019-12-11" version="1">MAHHPWASSGQENSAEDTHFFLEIEGFEPNPAANKPSPPVFPKPMDSNIRPCNPGSCEDMDSPQSPQDDITETPSNPSSPCAALAKEEQKRNRKRLKKRIFAAAAEGSVQELGGLLGELRELARRHRTVDTQDYVLHKLTASDTGKTCLMKALLNINPNTEDIVRTLLAFAEENDILERFINAEYTEEAYRGQTALNIAIERRQVAITETLIEKGADVNAHAKGLFFNPKHKHEGFYFGETPLALAACTNQPEIVQLLMDNEKTDIASQDSRGNNILHALVTVAEDFKTQNDFVKEMYDMILLRSRDPALETAQNKDGLTPLQLAAKTGKSEILKYILSREIKEKLQRSLSRKFTDWAYGPVSSSLYDLTDVDTTADNSVLEIIVYNTNIDVSHAQRRGSGRGGMWEKLGGGAKSGGGGGVCILHYKVCSLREGLLYFCLVSSKYLINASQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7Q8</accession>
    <name>A0A5F8H7Q8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Transferrin receptor protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TFRC</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
            <topology evidence="15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="15">Stearoylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7Q8"/>
    <dbReference type="Ensembl" id="ENSMODT00000075141.1">
        <property type="protein sequence ID" value="ENSMODP00000055594.1"/>
        <property type="gene ID" value="ENSMODG00000018427.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234598"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018427">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004998">
        <property type="term" value="F:transferrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033572">
        <property type="term" value="P:transferrin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09848">
        <property type="entry name" value="M28_TfR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02128">
        <property type="entry name" value="PA_TfR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000002">
        <property type="entry name" value="Transferrin receptor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000045">
        <property type="entry name" value="Transferrin receptor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000010">
        <property type="entry name" value="Transferrin receptor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037324">
        <property type="entry name" value="TfR1/2_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF26">
        <property type="entry name" value="TRANSFERRIN RECEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13 15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="17">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="19">
        <location>
            <begin position="398"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="18">
        <location>
            <begin position="646"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="769" mass="86010" checksum="4E88969618E4776C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7Q9</accession>
    <name>A0A5F8H7Q9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Disks large homolog 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7Q9"/>
    <dbReference type="Ensembl" id="ENSMODT00000058463.1">
        <property type="protein sequence ID" value="ENSMODP00000055995.1"/>
        <property type="gene ID" value="ENSMODG00000020512.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159409"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020512">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06723">
        <property type="entry name" value="PDZ1_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06724">
        <property type="entry name" value="PDZ2_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06795">
        <property type="entry name" value="PDZ3_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000008">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000001">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000001">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000058">
        <property type="entry name" value="Disks large homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000049">
        <property type="entry name" value="disks large homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000002">
        <property type="entry name" value="Disks large homolog 4 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.470">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019583">
        <property type="entry name" value="DLG1-4_PDZ_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016313">
        <property type="entry name" value="DLG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019590">
        <property type="entry name" value="DLG1_PEST_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015143">
        <property type="entry name" value="L27_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF5">
        <property type="entry name" value="DISKS LARGE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09058">
        <property type="entry name" value="L27_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10608">
        <property type="entry name" value="MAGUK_N_PEST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10600">
        <property type="entry name" value="PDZ_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001741">
        <property type="entry name" value="MAGUK_DLGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01277">
        <property type="entry name" value="MAGUK_N_PEST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="18">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="191"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="286"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="433"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="548"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="16">
        <location>
            <begin position="704"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="656"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="822" mass="90986" checksum="ED9EF5CAB1F370B4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7R3</accession>
    <name>A0A5F8H7R3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat domain 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TTC33</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7R3"/>
    <dbReference type="Ensembl" id="ENSMODT00000072106.1">
        <property type="protein sequence ID" value="ENSMODP00000055599.1"/>
        <property type="gene ID" value="ENSMODG00000049452.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017462"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000049452">
        <property type="expression patterns" value="Expressed in uterus and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052658">
        <property type="entry name" value="TPR-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15544">
        <property type="entry name" value="OSMOSIS RESPONSIVE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15544:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="118" mass="13529" checksum="0C5F01F06FF708CF" modified="2019-12-11" version="1">MASFGWKRKIGEKVSKVTSQQFEAEAADEKGLVENEDVNWLHAIKRKKAILLEDCTEKSKRLKDEGAILAENRRSLYLKPLLLLVLQSKGRDLSHFLSVRSHFRGTGRQFTNGMKHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7R4</accession>
    <name>A0A5F8H7R4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Keratin, type I cytoskeletal 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC100618392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7R4"/>
    <dbReference type="Ensembl" id="ENSMODT00000072300.1">
        <property type="protein sequence ID" value="ENSMODP00000055246.1"/>
        <property type="gene ID" value="ENSMODG00000014647.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163247"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014647">
        <property type="expression patterns" value="Expressed in liver and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF184">
        <property type="entry name" value="KERATIN, TYPE I CYTOSKELETAL 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="232" mass="26383" checksum="4C2BC76E6E8251AB" modified="2019-12-11" version="1">MIRARQWGLGDLPREMNALRGQVGGDVSVEMDAAPGVDLSRILSEMRDQYEKMAEKNRKDAEDWFFTKTEELNREVATNTEALQSSKTEITELRRTVQNLEIELQSQLSMKASLEGTLAETEARYGAQLAQLQGLISSIEQQLCELRCDMERQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLASQYSSTLSSGSGREAMVTSRQVRTIVEEVQDGKVVSSREQLHRSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7R7</accession>
    <name>A0A5F8H7R7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Janus kinase and microtubule interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">JAKMIP1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the JAKMIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7R7"/>
    <dbReference type="FunCoup" id="A0A5F8H7R7">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000070464.1">
        <property type="protein sequence ID" value="ENSMODP00000055857.1"/>
        <property type="gene ID" value="ENSMODG00000002810.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153713"/>
    <dbReference type="InParanoid" id="A0A5F8H7R7"/>
    <dbReference type="OMA" id="QMCALQQ"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002810">
        <property type="expression patterns" value="Expressed in spinal cord and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050811">
        <property type="term" value="F:GABA receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024836">
        <property type="entry name" value="JAKMIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031994">
        <property type="entry name" value="JAKMIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18935">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18935:SF6">
        <property type="entry name" value="JANUS KINASE AND MICROTUBULE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16034">
        <property type="entry name" value="JAKMIP_CC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Janus kinase and microtubule-interacting protein C-terminal" evidence="5">
        <location>
            <begin position="415"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="148"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="287"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="521"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="747"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="839" mass="98509" checksum="F019987574075F9B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H803</accession>
    <name>A0A5F8H803_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Centrosomal protein of 170 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CEP170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in microtubule organization. Required for centriole subdistal appendage assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with CCDC68 and CCDC120; leading to recruitment to centrosomes. Interacts with PLK1. Interacts with NIN. Interacts with FHDC1. Interacts with CCDC61. Interacts with TBK1; efficient complex formation may be dependent on the presence of CCDC61.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CEP170 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000078498.1">
        <property type="protein sequence ID" value="ENSMODP00000055331.1"/>
        <property type="gene ID" value="ENSMODG00000006701.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155103"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006701">
        <property type="expression patterns" value="Expressed in spermatid and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22724">
        <property type="entry name" value="FHA_Cep170A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000018">
        <property type="entry name" value="Centrosomal protein of 170 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029300">
        <property type="entry name" value="CEP170_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF17">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15308">
        <property type="entry name" value="CEP170_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="13">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="431"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="748"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1192"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1335"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="504"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="611"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="761"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="808"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="900"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="925"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="962"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1002"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1044"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1107"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1204"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1406" mass="156086" checksum="51F243EB936F2635" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H804</accession>
    <name>A0A5F8H804_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Piezo type mechanosensitive ion channel component 1 (Er blood group)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PIEZO1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000059598.1">
        <property type="protein sequence ID" value="ENSMODP00000055694.1"/>
        <property type="gene ID" value="ENSMODG00000004122.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157348"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004122">
        <property type="expression patterns" value="Expressed in lung and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF5">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="843"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="928"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="956"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1082"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1536"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1564"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1590"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1648"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1779"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1822"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1850"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1883"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1992"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2249"/>
            <end position="2272"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM1-24" evidence="15">
        <location>
            <begin position="302"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="13">
        <location>
            <begin position="1058"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo transmembrane helical unit" evidence="14">
        <location>
            <begin position="1546"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="16">
        <location>
            <begin position="1777"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="12">
        <location>
            <begin position="2052"/>
            <end position="2336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1437"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1708"/>
            <end position="1737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2338" mass="268677" checksum="3D10EFDF3DA623E5" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H805</accession>
    <name>A0A5F8H805_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Retinoid X receptor beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RXRB</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H805"/>
    <dbReference type="Ensembl" id="ENSMODT00000076646.1">
        <property type="protein sequence ID" value="ENSMODP00000056093.1"/>
        <property type="gene ID" value="ENSMODG00000014249.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100027006"/>
    <dbReference type="KEGG" id="mdo:100027006"/>
    <dbReference type="CTD" id="6257"/>
    <dbReference type="GeneTree" id="ENSGT00940000159208"/>
    <dbReference type="OrthoDB" id="5873264at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014249">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06956">
        <property type="entry name" value="NR_DBD_RXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06943">
        <property type="entry name" value="NR_LBD_RXR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000002">
        <property type="entry name" value="Retinoic acid receptor RXR-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000005">
        <property type="entry name" value="Retinoic acid receptor RXR-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="443" mass="47997" checksum="639AFD4E0F13648D" modified="2019-12-11" version="1">MPLAALPSLIYPSPAPMPRGSVGLWGSVARSIVGPGPGGGGGGWRWRPENNKPRSRSRGERDGTGWATAGGINSTVSLPGGGSGPPEDVKPPMLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKEKDGEGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGAGGGGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSISVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPGEVEILREKVYASLESYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H806</accession>
    <name>A0A5F8H806_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil alpha-helical rod protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-helical coiled-coil rod protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CCHCR1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be a regulator of keratinocyte proliferation or differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H806"/>
    <dbReference type="Ensembl" id="ENSMODT00000076972.1">
        <property type="protein sequence ID" value="ENSMODP00000056095.1"/>
        <property type="gene ID" value="ENSMODG00000015829.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153251"/>
    <dbReference type="OMA" id="LTCWREK"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015829">
        <property type="expression patterns" value="Expressed in testis and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009800">
        <property type="entry name" value="HCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46822">
        <property type="entry name" value="COILED-COIL ALPHA-HELICAL ROD PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46822:SF1">
        <property type="entry name" value="COILED-COIL ALPHA-HELICAL ROD PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07111">
        <property type="entry name" value="HCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="116"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="468"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="751" mass="86521" checksum="D89EC5D1610D928B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H808</accession>
    <name>A0A5F8H808_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pulmonary surfactant-associated protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100016579</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex of 6 set of homotrimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Surface film</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the SFTPA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007478564.1">
        <property type="nucleotide sequence ID" value="XM_007478502.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007478565.1">
        <property type="nucleotide sequence ID" value="XM_007478503.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H808"/>
    <dbReference type="Ensembl" id="ENSMODT00000055926.1">
        <property type="protein sequence ID" value="ENSMODP00000055336.1"/>
        <property type="gene ID" value="ENSMODG00000037815.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100016579"/>
    <dbReference type="KEGG" id="mdo:100016579"/>
    <dbReference type="GeneTree" id="ENSGT00940000156653"/>
    <dbReference type="OMA" id="CHEIGGT"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000037815">
        <property type="expression patterns" value="Expressed in liver and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007585">
        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000199">
        <property type="entry name" value="Mannose binding lectin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF13">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-0305">Gaseous exchange</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0767">Surface film</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023890582" description="Pulmonary surfactant-associated protein A" evidence="15">
        <location>
            <begin position="22"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="16">
        <location>
            <begin position="139"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="253" mass="27549" checksum="14610DB91F1BFC43" modified="2019-12-11" version="1">MMVLLPLLSLLLLEWALIGSCSETGENEEQPFTYSATHCHGPWITGLPGRDGRDGKAGSKGEKGDPGEGLRGLQGNPGKVGPPGNPGIQGPPGIKGMKGEPGEMCSSPTKEIHNVTSDLETRLLKVIKALTLYGSMAELGGKFYVTTGQSSDFFTINKTCHEMGGIVATPRNKEENAAIMKLVVRHNTYAFLGLREGIQPGKFYYVDGSPVNYTNWYYGTPDGQGQENCVEMYTDGTWNDKYCYKHRLGICEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H809</accession>
    <name>A0A5F8H809_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alkaline ceramidase</fullName>
            <ecNumber evidence="14">3.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ACER3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:41299"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:41300"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an N-acylsphinganine + H2O = sphinganine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:33551"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33552"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_007490977.2">
        <property type="nucleotide sequence ID" value="XM_007490915.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H809"/>
    <dbReference type="Ensembl" id="ENSMODT00000056759.1">
        <property type="protein sequence ID" value="ENSMODP00000055699.1"/>
        <property type="gene ID" value="ENSMODG00000005216.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100027829"/>
    <dbReference type="CTD" id="55331"/>
    <dbReference type="GeneTree" id="ENSGT00730000110920"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005216">
        <property type="expression patterns" value="Expressed in spermatid and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="253" mass="29599" checksum="EC957B48E4CC5CE4" modified="2019-12-11" version="1">MIIFDNCLDMWDEGDRGVKGNTLSNLIMILPPIYGAIQTVRDGLEKRYIASYLALTVVGLGSWCFHMTLQYEMQLLDELPMIYSCCIFVYCMFESFKAKNTVNYHLIFILVLFSLIVTTVYLKVKEPIFHQVMYGLLVFALVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFFLWNVDNIFCESLRSFRTKVPPFVGVFTQLHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLLGIWPTILVEPPKKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H810</accession>
    <name>A0A5F8H810_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Erythroid differentiation regulatory factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EDRF1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H810"/>
    <dbReference type="FunCoup" id="A0A5F8H810">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000056098"/>
    <dbReference type="Ensembl" id="ENSMODT00000079275.1">
        <property type="protein sequence ID" value="ENSMODP00000056098.1"/>
        <property type="gene ID" value="ENSMODG00000010414.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014797"/>
    <dbReference type="InParanoid" id="A0A5F8H810"/>
    <dbReference type="OMA" id="AFLYCNM"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010414">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056582">
        <property type="entry name" value="EDRF1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056583">
        <property type="entry name" value="EDRF1_TPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000:SF1">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23788">
        <property type="entry name" value="EDRF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23723">
        <property type="entry name" value="TPR_EDRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EDRF1 N-terminal" evidence="3">
        <location>
            <begin position="42"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="EDRF1 TPR repeats region" evidence="2">
        <location>
            <begin position="833"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1264" mass="140889" checksum="93389872860662C4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H817</accession>
    <name>A0A5F8H817_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abhydrolase domain containing 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ABHD18</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H817"/>
    <dbReference type="Ensembl" id="ENSMODT00000062698.1">
        <property type="protein sequence ID" value="ENSMODP00000055346.1"/>
        <property type="gene ID" value="ENSMODG00000012274.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014635"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012274">
        <property type="expression patterns" value="Expressed in spermatid and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="130" mass="14948" checksum="DF0962ECA9A92564" modified="2025-10-08" version="2">MGIYLFQFIVPKEWNNKYRPVCIHLAGTGDHHYWRRRTLMARPMIKEARMASLLLENPYYILLKPKDQVRSSLKNVSDLFVMGGALVLESAALLHWLEREGYGPLGMTGISMGGHVSFYVVFICFILLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H818</accession>
    <name>A0A5F8H818_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SET binding factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SBF2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000074384.1">
        <property type="protein sequence ID" value="ENSMODP00000056108.1"/>
        <property type="gene ID" value="ENSMODG00000008083.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155385"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008083">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13339">
        <property type="entry name" value="PH-GRAM_MTMR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01235">
        <property type="entry name" value="PH_Sbf1_hMTMR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000093">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.200:FF:000004">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000006">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037823">
        <property type="entry name" value="MTMR13_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF4">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="6">
        <location>
            <begin position="5"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Myotubularin phosphatase" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="1672"/>
            <end position="1776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1778" mass="200513" checksum="04DDFDFF417A321F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H822</accession>
    <name>A0A5F8H822_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capping protein regulator and myosin 1 linker 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CARMIL2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H822"/>
    <dbReference type="Ensembl" id="ENSMODT00000075935.1">
        <property type="protein sequence ID" value="ENSMODP00000056113.1"/>
        <property type="gene ID" value="ENSMODG00000005734.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161003"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005734">
        <property type="expression patterns" value="Expressed in cerebellum and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031943">
        <property type="entry name" value="CARMIL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF32">
        <property type="entry name" value="CAPPING PROTEIN, ARP2_3 AND MYOSIN-I LINKER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16000">
        <property type="entry name" value="CARMIL_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARMIL C-terminal" evidence="2">
        <location>
            <begin position="646"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="CARMIL C-terminal" evidence="2">
        <location>
            <begin position="780"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1188" mass="128690" checksum="B471FBADBA537192" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H823</accession>
    <name>A0A5F8H823_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Charged multivesicular body protein 4C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CHMP4C</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H823"/>
    <dbReference type="Ensembl" id="ENSMODT00000060388.1">
        <property type="protein sequence ID" value="ENSMODP00000055351.1"/>
        <property type="gene ID" value="ENSMODG00000006220.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159257"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006220">
        <property type="expression patterns" value="Expressed in kidney and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1060:FF:000001">
        <property type="entry name" value="Charged multivesicular body protein 4b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF77">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="223" mass="25106" checksum="529F7397AE3513FE" modified="2019-12-11" version="1">MSKLGKLFKGGNSSKSKAAPSAQEALARLRETEEMLGKKQEYLETRIQRELALAKKHGTHNKRAALQALKRKKRFEKQLTQIDGTLSTIEFQREALENSHTNTEVLRNMGYAAKAMKAVHENMDINKIDDLMQEITEQQDIAQEISEAFSQRVGFGDDFDEDELMAELEELEQEELNKKMTNIRLPSVPSTSLPAHPGRQPSLPSSSRPSRAGKLPIELLGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H826</accession>
    <name>A0A5F8H826_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">IKAROS family zinc finger 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IKZF3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Ikaros C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H826"/>
    <dbReference type="Ensembl" id="ENSMODT00000063949.1">
        <property type="protein sequence ID" value="ENSMODP00000056118.1"/>
        <property type="gene ID" value="ENSMODG00000012901.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160462"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012901">
        <property type="expression patterns" value="Expressed in blood and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030098">
        <property type="term" value="P:lymphocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000073">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000265">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002372">
        <property type="entry name" value="IKAROS family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000080">
        <property type="entry name" value="IKAROS family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000168">
        <property type="entry name" value="zinc finger protein Eos isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN AIOLOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="475" mass="54448" checksum="D4D6F0634A4565DE" modified="2019-12-11" version="1">MEDTQSTVELRNSQAQPVFTEGQVILNDYSSSKPQEVENMDSGEENKDQVPPVEDEDMGDDSMKVKDEYSERDENTLKPDPMENAEDPEIPYSYPREYNEYESIKLERHAVSYDSSRPTSGKMNCDVCGLACISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQNTGMGDTGEKRHCFEVNYNSSYMYEKESEMIQSRMMDQAINNAITYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRTELPNGGPQDLEKKSAHLSDKCLPSERGLSPNNSGHDSTDTDSNHEERQNHAYQQNHLIPPRARNGMPTLKELPHSYELLKPPSICPRDTIKVINKDGEVMGVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRVMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H827</accession>
    <name>A0A5F8H827_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Solute carrier family 12 member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SLC12A7</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H827"/>
    <dbReference type="Ensembl" id="ENSMODT00000074536.1">
        <property type="protein sequence ID" value="ENSMODP00000055957.1"/>
        <property type="gene ID" value="ENSMODG00000000878.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157657"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000878">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000049">
        <property type="entry name" value="Solute carrier family 12 (potassium/chloride transporter), member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000076">
        <property type="entry name" value="KCL_cotranspt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF47">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01081">
        <property type="entry name" value="KCLTRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="141"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="436"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="503"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="781"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115653" checksum="7F7506060140131D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H830</accession>
    <name>A0A5F8H830_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Replication protein A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPA2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H830"/>
    <dbReference type="Ensembl" id="ENSMODT00000052786.1">
        <property type="protein sequence ID" value="ENSMODP00000056230.1"/>
        <property type="gene ID" value="ENSMODG00000010736.4"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000059992.1">
        <property type="protein sequence ID" value="ENSMODP00000041739.1"/>
        <property type="gene ID" value="ENSMODG00000010736.4"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000080748.1">
        <property type="protein sequence ID" value="ENSMODP00000055719.1"/>
        <property type="gene ID" value="ENSMODG00000010736.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010045"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010736">
        <property type="expression patterns" value="Expressed in hindlimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000168">
        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="6">
        <location>
            <begin position="70"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="179" mass="19564" checksum="EE0AAF897FDDB2EB" modified="2019-12-11" version="1">MTAAPMDVRQWVDTDDTSSENTVVPPETYVKVAGHLRSFQNKKSLVAFKILPLEDMNEFTIHILETVNAHMVLSQSISQPLAGRPSLNTSGIGDTGGFGGNSFSGNNFMPANGLTVTQNQVLNLIKACPRPEGMNFQDLKTQLHNVNVSVIKQAVDFLSNEGHIYSTVDDDHFKSTDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H832</accession>
    <name>A0A5F8H832_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ankyrin repeat and sterile alpha motif domain containing 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ANKS1A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H832"/>
    <dbReference type="Ensembl" id="ENSMODT00000066487.1">
        <property type="protein sequence ID" value="ENSMODP00000055361.1"/>
        <property type="gene ID" value="ENSMODG00000013855.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155806"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013855">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01274">
        <property type="entry name" value="PTB_Anks"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09499">
        <property type="entry name" value="SAM_AIDA1AB-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09500">
        <property type="entry name" value="SAM_AIDA1AB-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000015">
        <property type="entry name" value="ankyrin repeat and sterile alpha motif domain-containing protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000045">
        <property type="entry name" value="Ankyrin repeat and sterile alpha motif domain-containing protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000099">
        <property type="entry name" value="ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041880">
        <property type="entry name" value="SAM_ANKS1_repeat1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041882">
        <property type="entry name" value="SAM_ANKS1_repeat2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF4">
        <property type="entry name" value="ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="769"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="840"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="441"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="926"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1143"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="683"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="926"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1226"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1237" mass="133862" checksum="EA3AD750D4FF6154" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H833</accession>
    <name>A0A5F8H833_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein 821</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF821</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H833"/>
    <dbReference type="Ensembl" id="ENSMODT00000080284.1">
        <property type="protein sequence ID" value="ENSMODP00000056125.1"/>
        <property type="gene ID" value="ENSMODG00000002425.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159421"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002425">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000582">
        <property type="entry name" value="zinc finger protein 821 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="371" mass="41972" checksum="0354AD27D7249FF6" modified="2019-12-11" version="1">MSRRKQTNPNKVHCDSEGDEEETTQDEVSSHTSEEDGGMVKVKKELENTEQSVGGNEVTGEHEVTEHLNSDPMLGLCQCPLCQLDCGSREQLIAHVYQHTAAVVSAKSYVCPVCGRALSSPGSLGRHLLIHSEDQRSNCAVCGARFTSHATFNSEKLPEVLNMESIPPNHSEGPSNAEGKDIAFSPPVYPAGILLVCNNCAAYRKLLEAQAPGVRKWALRRQNEPLEVRLQRLERERTAKKSRRDNETPEEREVRRMRDREAKRLQRLQETDEQRARRLQRDREAMRLKRANETPEKRQARLIREREAKRLKRRLEKMDMMLRAQFGQDPSAVAALAAEMSFFQLPVGGVELESQLLGKVAFEEQNSSSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H834</accession>
    <name>A0A5F8H834_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 260-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100619999</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H834"/>
    <dbReference type="Ensembl" id="ENSMODT00000088812.1">
        <property type="protein sequence ID" value="ENSMODP00000055962.1"/>
        <property type="gene ID" value="ENSMODG00000051297.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162725"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000051297">
        <property type="expression patterns" value="Expressed in uterus and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003268">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004104">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002079">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002573">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000044">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000801">
        <property type="entry name" value="zinc finger protein 461 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001402">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000292">
        <property type="entry name" value="zinc finger protein 619"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF96">
        <property type="entry name" value="ZINC FINGER PROTEIN 420-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="721" mass="82564" checksum="16A1EDA2F9C70478" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H835</accession>
    <name>A0A5F8H835_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Splicing factor 3b subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SF3B1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_056650137.1">
        <property type="nucleotide sequence ID" value="XM_056794159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H835"/>
    <dbReference type="Ensembl" id="ENSMODT00000059591.1">
        <property type="protein sequence ID" value="ENSMODP00000055724.1"/>
        <property type="gene ID" value="ENSMODG00000012275.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022236"/>
    <dbReference type="CTD" id="23451"/>
    <dbReference type="GeneTree" id="ENSGT00390000018393"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012275">
        <property type="expression patterns" value="Expressed in uterus and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="144" mass="16216" checksum="9782AFB35EB15EFA" modified="2019-12-11" version="1">MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGNDSRFAGYVTSIAATELEDDDDDYSSSTSLLGQKKSGYQPTVALLNDIPQSTEQYDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGRRTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H837</accession>
    <name>A0A5F8H837_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Signal peptide, CUB and EGF-like domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Protein CEGP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Scube/You</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SCUBE2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H837"/>
    <dbReference type="Ensembl" id="ENSMODT00000063606.1">
        <property type="protein sequence ID" value="ENSMODP00000055366.1"/>
        <property type="gene ID" value="ENSMODG00000007737.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153185"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007737">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000032">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000002">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000199">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000237">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000028">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000029">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000028">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000030">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000035">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000002">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000008">
        <property type="entry name" value="Signal peptide, CUB domain, EGF-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052071">
        <property type="entry name" value="SCUB_EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046:SF3">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023860812" description="Signal peptide, CUB and EGF-like domain-containing protein 2" evidence="16">
        <location>
            <begin position="32"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="322"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="17">
        <location>
            <begin position="799"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="964" mass="106532" checksum="9FBE476BC7C2B8A4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F6TJP1</accession>
    <name>F6TJP1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein unc-93 homolog A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UNC93A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6TJP1"/>
    <dbReference type="Ensembl" id="ENSMODT00000040121.3">
        <property type="protein sequence ID" value="ENSMODP00000038521.2"/>
        <property type="gene ID" value="ENSMODG00000025690.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mdo:100032638"/>
    <dbReference type="eggNOG" id="KOG3097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063359"/>
    <dbReference type="HOGENOM" id="CLU_025356_1_1_1"/>
    <dbReference type="OrthoDB" id="78663at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025690">
        <property type="expression patterns" value="Expressed in spermatocyte and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6TJP1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17406">
        <property type="entry name" value="MFS_unc93A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000290">
        <property type="entry name" value="Unc-93 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000038521.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="452" mass="50493" checksum="10C1002B176C0FFE" modified="2013-01-09" version="2">MESHLKNVLVVSFGFLFLFTAYGALQNLQSSLNTEAGLGVATLSVIYASVIVSSMFLPQILIKTFGCKWTITYSMCCYIIFSVGNFSAKWYTLIPTAIILGLGGAPLWSAEASYLTMSGNAYALKAGKLGRDVVNQYFGIFFLIFQSSGVWGNLISSLVLKQQIYRATKEELLNCGAQDCYSRSPTTNNTNTQRPQSNLIYILLGIYTGSGILAVILVAVFLDHIPNDESENEDKKNESFWSSVLATFRHLKDDRRQVLLIPLTMYSGFEQGFLSSDYTKSYVTCVLGIQYVGYSMICFSATTSFSSLLYGKISQYTGRAALYGVGSVIHFCCFFFLLVWKPHPNHKILFFLFPAFWGLADAVIQTQNNAIYGDLFVKNKEAAFANYRLWESLGFVIAFGYSTSLCVSMKLYILMVILFLSVALYGTVECLEQDQPFVEKDLNQRKEIPDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F6TK17</accession>
    <name>F6TK17_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatase and actin regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PHACTR2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Binds PPP1CA and actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6TK17"/>
    <dbReference type="Ensembl" id="ENSMODT00000021911.5">
        <property type="protein sequence ID" value="ENSMODP00000021535.5"/>
        <property type="gene ID" value="ENSMODG00000017255.5"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157628"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017255">
        <property type="expression patterns" value="Expressed in lung and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6TK17">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF5">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU301113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000021535.5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="564" mass="62595" checksum="8D6834AA9487703C" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F6UN53</accession>
    <name>F6UN53_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein TMEM103</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ELP6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Involved in cell migration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6UN53"/>
    <dbReference type="Ensembl" id="ENSMODT00000018031.2">
        <property type="protein sequence ID" value="ENSMODP00000017703.2"/>
        <property type="gene ID" value="ENSMODG00000014160.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011734"/>
    <dbReference type="HOGENOM" id="CLU_092581_2_0_1"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014160">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001078">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000017703.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="259" mass="28705" checksum="14992674A1D9621F" modified="2013-01-09" version="2">MFPELNNLLNVSPDKPEQGKFTLLCDAKTDGGFLVHHFLSFYLKANCKVCFVALLQSFSHYNIVGQKLGVNLIAARDRGQLVFFEGLKSTVEVLFGSKEQPNTLKFIRESSSDLKSLYEFVQKALTPSGDGSATSWKFPVLLVDDLSVLLSLGVEAVAVLDFIQYCRATVCCQLKGNVVALVHDSDQTEDEENAMLMNALGHQSSLILRAEGLVTGFCKDVHGQLKILRRGLLQPKNDEAEQWNTLLKVIEIPCARARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F6VQ74</accession>
    <name>F6VQ74_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Myosin-binding protein C, cardiac-type</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">C-protein, cardiac muscle isoform</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MYBPC3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the immunoglobulin superfamily. MyBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6VQ74"/>
    <dbReference type="Ensembl" id="ENSMODT00000025277.4">
        <property type="protein sequence ID" value="ENSMODP00000024836.3"/>
        <property type="gene ID" value="ENSMODG00000019908.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWRQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157698"/>
    <dbReference type="HOGENOM" id="CLU_006405_1_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019908">
        <property type="expression patterns" value="Expressed in heart and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05894">
        <property type="entry name" value="Ig_C5_MyBP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000225">
        <property type="entry name" value="Myosin-binding protein C, cardiac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000326">
        <property type="entry name" value="Myosin-binding protein C, cardiac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000518">
        <property type="entry name" value="Myosin-binding protein C, cardiac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000576">
        <property type="entry name" value="Myosin-binding protein C, cardiac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000060">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000062">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000070">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000081">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000085">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000111">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040849">
        <property type="entry name" value="MyBP-C_THB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF20">
        <property type="entry name" value="MYOSIN-BINDING PROTEIN C, CARDIAC-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18362">
        <property type="entry name" value="THB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="103"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="327"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="404"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="597"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="719"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="817"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="916"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="1013"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="1126"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000024836.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1219" mass="135465" checksum="80549ACCFA6943AF" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F6W1M7</accession>
    <name>F6W1M7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B-cell receptor CD22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Sialic acid-binding Ig-like lectin 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SIGLEC1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow. Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration. Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling. If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation. May form a complex with INPP5D/SHIP, GRB2 and SHC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000014565.3">
        <property type="protein sequence ID" value="ENSMODP00000014301.3"/>
        <property type="gene ID" value="ENSMODG00000011441.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286907"/>
    <dbReference type="HOGENOM" id="CLU_243945_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011441">
        <property type="expression patterns" value="Expressed in liver and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000921">
        <property type="entry name" value="sialoadhesin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056386">
        <property type="entry name" value="Ig_CD22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47243">
        <property type="entry name" value="SIALOADHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47243:SF1">
        <property type="entry name" value="SIALOADHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24518">
        <property type="entry name" value="Ig_CD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023934316" description="B-cell receptor CD22" evidence="10">
        <location>
            <begin position="19"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="13"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="238"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="325"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="412"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="511"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="609"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="692"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="782"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="878"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="969"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1062"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1152"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1248"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1334"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1432"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1523"/>
            <end position="1615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000014301.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1619" mass="174016" checksum="5D39A6A028C9D286" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>F6W1W9</accession>
    <name>F6W1W9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Solute carrier family 12 member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Na-Cl symporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Thiazide-sensitive sodium-chloride cotransporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">SLC12A2</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(out) + 2 chloride(out) + Na(+)(out) = K(+)(in) + 2 chloride(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72395"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:72396"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>chloride(out) + Na(+)(out) = chloride(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73887"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer; adopts a domain-swap conformation at the scissor helices connecting the transmembrane domain and C-terminal domain. Interacts with KLHL3. Interacts with IL18R1; this interaction is increased by IL18 treatment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6W1W9"/>
    <dbReference type="Ensembl" id="ENSMODT00000039766.3">
        <property type="protein sequence ID" value="ENSMODP00000038166.3"/>
        <property type="gene ID" value="ENSMODG00000013329.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2083">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155742"/>
    <dbReference type="HOGENOM" id="CLU_001883_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013329">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000018">
        <property type="entry name" value="solute carrier family 12 member 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013612">
        <property type="entry name" value="AA_permease_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002444">
        <property type="entry name" value="NKCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002443">
        <property type="entry name" value="SLC12A1/SLC12A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF58">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08403">
        <property type="entry name" value="AA_permease_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01207">
        <property type="entry name" value="NAKCLTRNSPRT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01208">
        <property type="entry name" value="NAKCLTRSPRT1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0868">Chloride</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="19" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="11" id="KW-0769">Symport</keyword>
    <keyword evidence="7 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease N-terminal" evidence="32">
        <location>
            <begin position="194"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="30">
        <location>
            <begin position="282"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="31">
        <location>
            <begin position="684"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="103"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="840"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="840"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00050884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00056815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00063035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00073714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00076232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00077939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF08403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000038166.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1096" mass="118479" checksum="72A06E73CFBBB33F" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>F6X4P7</accession>
    <name>F6X4P7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secretory carrier-associated membrane protein</fullName>
            <shortName evidence="5">Secretory carrier membrane protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SCAMP1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCAMP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6X4P7"/>
    <dbReference type="Ensembl" id="ENSMODT00000025064.4">
        <property type="protein sequence ID" value="ENSMODP00000024628.4"/>
        <property type="gene ID" value="ENSMODG00000019731.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157310"/>
    <dbReference type="HOGENOM" id="CLU_066546_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019731">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF8">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000024628.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="336" mass="37640" checksum="31CD0151156AD1F9" modified="2019-12-11" version="3">MSLYVSDTFVSPDLCNPFEDPSVTQVTRNMPPGLDEYNPFSDSRTAPPGNVKMPNVPSTQPAIMKPTEEAPTYTQIAKEHALAQAELLKRQEELERKAAELDRREREMQSLNQHGGRKNNWPPLPGNFPVGPCFYQDFSVDIPVEFQKTVKIMYYLWMFHAVTLFLNIFGCLAWFCVEPGRGVDFGLSILWFMLFTPCSFVCWYRPLYGAFRSDSSFRFFVFFFVYICQFAVHVLQAAGFQSWGNCGWISSLTGLNKSIPVGIMMMIIAALFTASAVISLVMFKKVHGLYRTTGASFEKAQQEFATGVMSNKTVQTAAANAASTAATSAAQNAFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F7AMS2</accession>
    <name>F7AMS2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ERLEC1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056670001.1">
        <property type="nucleotide sequence ID" value="XM_056814023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7AMS2"/>
    <dbReference type="Ensembl" id="ENSMODT00000002037.3">
        <property type="protein sequence ID" value="ENSMODP00000001995.3"/>
        <property type="gene ID" value="ENSMODG00000001631.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100032077"/>
    <dbReference type="CTD" id="27248"/>
    <dbReference type="eggNOG" id="KOG3394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063603"/>
    <dbReference type="HOGENOM" id="CLU_048035_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001631">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000003">
        <property type="entry name" value="Endoplasmic reticulum lectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000040">
        <property type="entry name" value="Endoplasmic reticulum lectin 1-like isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="133"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000001995.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="467" mass="53233" checksum="3DFC0458D21767D3" modified="2019-12-11" version="2">MGQGGSDGGGGGGGGWRKRRRRMEEGGGGGRRLVPGAPVLLVLCGLLEASGGGRVLPPLSDDIPFRVNWPGTEFSLPTAGVFYKEENYVIMTTVDKERYKCILPLVASGDEEEDKDYKGPTPGELLEPLFKQSSCSYRIESYWTYEVCHGKHIRQYHEEKETGQKINIQEYFLGNKIKKNTVTETEKEEKENEIFKENSKEIPTKNIEGQMTPYYAVWMGNGTPCSLRQNLPRSSMVMYICHPEAKHEILSVAEVTTCEYEVVILTPLLCNHPKYRFRSSPVNDIFCQSLPGSPLKPHNLVQLEQQQEVMKIPFRRIKEEEVHSGKEDKFTFVPKPVALGTHQLLTVGTTHISKLTDDQLIKEFLSGSYCFHGGVGWWKYEFCYGKHVHQYHEDKEVGKTSVIVGTWNKEEHIEWAKKNTARAYHLRDDGTQIVRKVLETKGVPINWRMAEQVMVYEYYGMLLCPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>F7AMT5</accession>
    <name>F7AMT5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synembryn</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein Ric-8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RIC8B</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007503428.1">
        <property type="nucleotide sequence ID" value="XM_007503366.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7AMT5"/>
    <dbReference type="Ensembl" id="ENSMODT00000002036.5">
        <property type="protein sequence ID" value="ENSMODP00000001994.4"/>
        <property type="gene ID" value="ENSMODG00000001629.5"/>
    </dbReference>
    <dbReference type="GeneID" id="100023398"/>
    <dbReference type="CTD" id="55188"/>
    <dbReference type="eggNOG" id="KOG4464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014700"/>
    <dbReference type="HOGENOM" id="CLU_018602_1_0_1"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001629">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008376">
        <property type="entry name" value="Chaperone_Ric-8_A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF2">
        <property type="entry name" value="SYNEMBRYN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01802">
        <property type="entry name" value="SYNEMBRYN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000001994.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="546" mass="61757" checksum="745B803D8435F1F3" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F7C1U8</accession>
    <name>F7C1U8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bile acid-CoA:amino acid N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BAAT</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7C1U8"/>
    <dbReference type="Ensembl" id="ENSMODT00000018344.4">
        <property type="protein sequence ID" value="ENSMODP00000018012.4"/>
        <property type="gene ID" value="ENSMODG00000014410.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQ8Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01010000222336"/>
    <dbReference type="HOGENOM" id="CLU_029849_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014410">
        <property type="expression patterns" value="Expressed in liver and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2240:FF:000001">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2240">
        <property type="entry name" value="Acyl-CoA thioester hydrolase/BAAT N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006862">
        <property type="entry name" value="Thio_Ohase/aa_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042490">
        <property type="entry name" value="Thio_Ohase/BAAT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF18">
        <property type="entry name" value="BILE ACID-COA:AMINO ACID N-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04775">
        <property type="entry name" value="Bile_Hydr_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="3">
        <location>
            <begin position="205"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000018012.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="314" mass="34604" checksum="FCDC895625181471" modified="2019-12-11" version="3">MAQIIVHPKTALVDVPLQIRVTGLLPSQLIMLQASLTDERGELFQSQVFYKADENGEVDLEHAGALGGDYVGIHPMGLFWSMKPKKMLSRLLKRDVINSPFLVHLSVYDITKPFSSSPDSLMASETVERWYSTPGVQRIQLKEGRVRGALFLPPGDGPFPGVIDLFGGIGGLVEFRASLLASHGFATLALAYFAYDDLPKNLDVIDIEYFEEAADILLRHPKVLGPSIGIVSVSRGAQIGMAMATFLKQVAATVCINGVFLAEQVVIKYRNEKFFSFSQHLERLRINELGLLQGYAHSIPVHPPVLLPQLLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F7D4Z3</accession>
    <name>F7D4Z3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Thrombospondin type-1 domain-containing protein 7A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">THSD7B</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in actin cytoskeleton rearrangement.</text>
    </comment>
    <comment type="function">
        <text evidence="15">The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="FunCoup" id="F7D4Z3">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000001348"/>
    <dbReference type="Ensembl" id="ENSMODT00000001376.4">
        <property type="protein sequence ID" value="ENSMODP00000001348.3"/>
        <property type="gene ID" value="ENSMODG00000001131.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159262"/>
    <dbReference type="HOGENOM" id="CLU_004819_0_0_1"/>
    <dbReference type="InParanoid" id="F7D4Z3"/>
    <dbReference type="OMA" id="WGPCSEN"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001131">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000014">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000017">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000018">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000020">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000027">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000031">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000050">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000063">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000015">
        <property type="entry name" value="Thrombospondin, type I, domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056991">
        <property type="entry name" value="TSP1_TSH7A-B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF7">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23308">
        <property type="entry name" value="TSP1_TSH7A-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1560"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="341"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="606"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="742"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="1006"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="1254"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="1376"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="domain" description="Thrombospondin type-1" evidence="19">
        <location>
            <begin position="1480"/>
            <end position="1518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF23308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000001348.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1620" mass="181854" checksum="ED42B27C1890A2E8" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F7DVR5</accession>
    <name>F7DVR5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain containing 3 centriole elongation regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">C2CD3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000009426.4">
        <property type="protein sequence ID" value="ENSMODP00000009245.4"/>
        <property type="gene ID" value="ENSMODG00000007448.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048072"/>
    <dbReference type="HOGENOM" id="CLU_000804_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007448">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08683">
        <property type="entry name" value="C2_C2cd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037775">
        <property type="entry name" value="C2_C2CD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057537">
        <property type="entry name" value="C2_C2CD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254:SF1">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25339">
        <property type="entry name" value="C2_C2CD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="715"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="912"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1097"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1537"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1495"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1734"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1823"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2006"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2130"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1500"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1743"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2018"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2130"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2151"/>
            <end position="2167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000009245.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2186" mass="243217" checksum="B1D09DF7B95D7479" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F7EZ69</accession>
    <name>F7EZ69_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EXOC6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7EZ69"/>
    <dbReference type="FunCoup" id="F7EZ69">
        <property type="interactions" value="861"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000007986"/>
    <dbReference type="Ensembl" id="ENSMODT00000008149.4">
        <property type="protein sequence ID" value="ENSMODP00000007986.4"/>
        <property type="gene ID" value="ENSMODG00000006431.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100023916"/>
    <dbReference type="CTD" id="54536"/>
    <dbReference type="eggNOG" id="KOG2176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005739"/>
    <dbReference type="HOGENOM" id="CLU_009437_0_0_1"/>
    <dbReference type="InParanoid" id="F7EZ69"/>
    <dbReference type="OMA" id="FPFHSEQ"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006431">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000001">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000001">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF2">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="6">
        <location>
            <begin position="50"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="5">
        <location>
            <begin position="413"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000007986.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="814" mass="94222" checksum="7F53B3F05FBDA072" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4G7</accession>
    <name>A0A5F8G4G7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MLLT10 histone lysine methyltransferase DOT1L cofactor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MLLT10</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007504947.1">
        <property type="nucleotide sequence ID" value="XM_007504885.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4G7"/>
    <dbReference type="Ensembl" id="ENSMODT00000054398.1">
        <property type="protein sequence ID" value="ENSMODP00000042335.1"/>
        <property type="gene ID" value="ENSMODG00000009138.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100019888"/>
    <dbReference type="CTD" id="8028"/>
    <dbReference type="GeneTree" id="ENSGT00940000157711"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009138">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20901">
        <property type="entry name" value="CC_AF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15708">
        <property type="entry name" value="ePHD_AF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15574">
        <property type="entry name" value="PHD_AF10_AF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000042">
        <property type="entry name" value="protein AF-10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000053">
        <property type="entry name" value="protein AF-10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049773">
        <property type="entry name" value="AF10-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049781">
        <property type="entry name" value="AF10/AF17_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049775">
        <property type="entry name" value="AF10_ePHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF93">
        <property type="entry name" value="PROTEIN AF-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="79"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="134"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="453"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="556"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="636"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="760"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="716"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1044" mass="110131" checksum="DF1F6DD4C3D73D56" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4G8</accession>
    <name>A0A5F8G4G8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="17">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LTK</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4G8"/>
    <dbReference type="Ensembl" id="ENSMODT00000081288.1">
        <property type="protein sequence ID" value="ENSMODP00000042334.1"/>
        <property type="gene ID" value="ENSMODG00000000117.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162680"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000117">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000117">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055163">
        <property type="entry name" value="ALK/LTK-like_GRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF294">
        <property type="entry name" value="LEUKOCYTE TYROSINE KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12810">
        <property type="entry name" value="ALK_LTK_GRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023916840" description="Tyrosine-protein kinase receptor" evidence="19">
        <location>
            <begin position="17"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="511"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="831"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="907" mass="95358" checksum="6AC3F8A7F051CF48" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4H0</accession>
    <name>A0A5F8G4H0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="10">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GNPDA2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:12173"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:12174"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4H0"/>
    <dbReference type="Ensembl" id="ENSMODT00000066983.1">
        <property type="protein sequence ID" value="ENSMODP00000042331.1"/>
        <property type="gene ID" value="ENSMODG00000020593.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014316"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020593">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF9">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="11">
        <location>
            <begin position="43"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="225" mass="25327" checksum="C241D316778DD1E6" modified="2019-12-11" version="1">MRLVILDNYALASEWAAKYICNRIIQFKPRKDRYFTLGLPTGLPRNHPESYHSYMWNNFFKHIDIDPNNVHILDGNASDLQAECDSFERKIEEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLELRVKTVKYFKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4H2</accession>
    <name>A0A5F8G4H2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Outer dense fiber of sperm tails 2 like</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ODF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4H2"/>
    <dbReference type="Ensembl" id="ENSMODT00000065369.1">
        <property type="protein sequence ID" value="ENSMODP00000042339.1"/>
        <property type="gene ID" value="ENSMODG00000000056.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063497"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000056">
        <property type="expression patterns" value="Expressed in ovary and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026099">
        <property type="entry name" value="Odf2-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23162">
        <property type="entry name" value="OUTER DENSE FIBER OF SPERM TAILS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23162:SF7">
        <property type="entry name" value="PROTEIN BCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="313"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="419"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="562" mass="65276" checksum="BE96FDD65C517602" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4H3</accession>
    <name>A0A5F8G4H3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Collagen type IV alpha 2 chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COL4A2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000072845.1">
        <property type="protein sequence ID" value="ENSMODP00000042378.1"/>
        <property type="gene ID" value="ENSMODG00000004632.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157234"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004632">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Collagen IV NC1" evidence="10">
        <location>
            <begin position="1154"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="227"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="625"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="815"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1024"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1077"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1377" mass="136499" checksum="FEA52CCAA5D53966" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4H6</accession>
    <name>A0A5F8G4H6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CD209 molecule</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4H6"/>
    <dbReference type="Ensembl" id="ENSMODT00000066843.1">
        <property type="protein sequence ID" value="ENSMODP00000048340.1"/>
        <property type="gene ID" value="ENSMODG00000014982.4"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000068834.1">
        <property type="protein sequence ID" value="ENSMODP00000042357.1"/>
        <property type="gene ID" value="ENSMODG00000014982.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160666"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014982">
        <property type="expression patterns" value="Expressed in liver and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="157"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="278" mass="31775" checksum="BBB63A93F9B6D06E" modified="2019-12-11" version="1">MCDLVAPKSPEMSGLDEEELMPSGWSPFDLGTQRSQSPRSFPAPWLRRLGFPLLLAFFVLSFILSIITLTQVFQNQRLYNSEQEAVQEKLNYLSAQLKGDQDLRDKGQLEASQFIEQLNKTLNLKINNQLEASKFTEQLNKTLSALCRPCPCQWKFYKDSCYYFSVAQASWETARKACEADGTNLAIISSSEEQNYLKLNLDSNRRPRWIGLSDKKKEGTWHWVDETALGQSFWNEGEPNNAGDEDCCELIPNGWNDAPCSKENYWICEKKASPCPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4H7</accession>
    <name>A0A5F8G4H7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CSNK2A2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4H7"/>
    <dbReference type="Ensembl" id="ENSMODT00000068313.1">
        <property type="protein sequence ID" value="ENSMODP00000042345.1"/>
        <property type="gene ID" value="ENSMODG00000014080.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004215"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014080">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF34">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="82"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="364" mass="42711" checksum="8BFD180BEF7806B5" modified="2019-12-11" version="1">MTNHYSISAPKTPNEVTKSWTQLKQLKTTMKSFTQGGDRSNLILSTFQQWKMDGKRESCGRGKTNRKTVSKRLPPKSNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGQDNYDQLVRIAKVLGTDELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPSSENSVLSSGLTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4I0</accession>
    <name>A0A5F8G4I0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000079719.1">
        <property type="protein sequence ID" value="ENSMODP00000042383.1"/>
        <property type="gene ID" value="ENSMODG00000017014.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160816"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017014">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23463">
        <property type="entry name" value="beta-trefoil_Ricin_vlAKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000013">
        <property type="entry name" value="Crystallin beta-gamma domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000006">
        <property type="entry name" value="Very large A-kinase anchor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000008">
        <property type="entry name" value="very large A-kinase anchor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000009">
        <property type="entry name" value="very large A-kinase anchor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000011">
        <property type="entry name" value="very large A-kinase anchor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000038">
        <property type="entry name" value="very large A-kinase anchor protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF38">
        <property type="entry name" value="VERY LARGE A-KINASE ANCHOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023836541" description="Beta/gamma crystallin 'Greek key' domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="7">
        <location>
            <begin position="1768"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="7">
        <location>
            <begin position="1958"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="7">
        <location>
            <begin position="2048"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="7">
        <location>
            <begin position="2227"/>
            <end position="2268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1033"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1546"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1594"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1718"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1601"/>
            <end position="1613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2404" mass="268887" checksum="BDEDADD097B6BC00" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4I1</accession>
    <name>A0A5F8G4I1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane and coiled-coil domain family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TMCC3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEX28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056654629.1">
        <property type="nucleotide sequence ID" value="XM_056798651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4I1"/>
    <dbReference type="Ensembl" id="ENSMODT00000074152.1">
        <property type="protein sequence ID" value="ENSMODP00000042362.1"/>
        <property type="gene ID" value="ENSMODG00000008293.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100012119"/>
    <dbReference type="CTD" id="57458"/>
    <dbReference type="GeneTree" id="ENSGT00940000157275"/>
    <dbReference type="OMA" id="APHGMES"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008293">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019394">
        <property type="entry name" value="TEX28/TMCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613">
        <property type="entry name" value="CEREBRAL PROTEIN-11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613:SF8">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10267">
        <property type="entry name" value="Tmemb_cc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="252"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="438" mass="49220" checksum="0B93AA86A89D8DD9" modified="2019-12-11" version="1">MNTLSLPLNIRRGGSDTNLNFDVPDGILDFHKVKLTADSLRQKILKVTEQIKIEQTSRDGNVAEYLKLVNSADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQNGTPRASKDNAKDNSKDGHGKTRPVGQGMESGKSGMPGVSLTPPMFFNKSREFANLIRNKFGSADNIAHLKSSLEEFRTDASSRVYGGSATIVTKPKYGSDDECSSGTSGSADSNGNQSFGTGGTNTLSSQGKLAMILEELREIKETQTQLAEDIESLKGQFKREYSFISQTLQEERYRYERLEDQLHDLTDLHQHETTNLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTVNAKVLLGKCINVILAFMTVILVCVSTIAKFVAPMMKSRFHILGTFFAVTLLAIFCKNWDHILCAIERIIIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4I2</accession>
    <name>A0A5F8G4I2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FCH and mu domain containing endocytic adaptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FCHO2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FCHO family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4I2"/>
    <dbReference type="Ensembl" id="ENSMODT00000063323.1">
        <property type="protein sequence ID" value="ENSMODP00000042346.1"/>
        <property type="gene ID" value="ENSMODG00000001742.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157105"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001742">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000005">
        <property type="entry name" value="SH3-containing GRB2-like protein 3-interacting protein 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF8">
        <property type="entry name" value="F-BAR DOMAIN ONLY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="11">
        <location>
            <begin position="3"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="506"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="268"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="774" mass="84721" checksum="10240A0B579D0DD2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4I3</accession>
    <name>A0A5F8G4I3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100026802</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the presentation of foreign antigens to the immune system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the MHC class I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4I3"/>
    <dbReference type="Ensembl" id="ENSMODT00000062079.1">
        <property type="protein sequence ID" value="ENSMODP00000042350.1"/>
        <property type="gene ID" value="ENSMODG00000050241.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271826"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000050241">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002474">
        <property type="term" value="P:antigen processing and presentation of peptide antigen via MHC class I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07698">
        <property type="entry name" value="IgC1_MHC_I_alpha3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000014">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000001">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010579">
        <property type="entry name" value="MHC_I_a_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF251">
        <property type="entry name" value="HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06623">
        <property type="entry name" value="MHC_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0490">MHC I</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023898328" description="Ig-like domain-containing protein" evidence="13">
        <location>
            <begin position="22"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="206"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="364" mass="41199" checksum="7057594116E42638" modified="2019-12-11" version="1">MKPYIISLGLLEILILKGTWAGSHSMRYFSTAMSRLDLREPRFFSVGYVDDQQFVRFDSYSESQRMEPRAAWMDKVDQDYWERETQMSRKAAQSYCVGLENLRSYYNQSETGVHIIQHMYGCEIFPNGSFKSGFEQYAYDGKDYICLNSETYSWTAIDPQAVNSKRKWEERSISEKEKAYLEETCVLWLHKHLENGKELLLRTDPPSVRVSRHSGPDGEVSLRCRAQGFYPAEISLTWLRDGEEQLQDTEFIETRPGGDGTFQKWAAVAMAPGQEDRYSCRVQHEALAQPLSLRWEPEAPSVWVIVGVTAGVLVLVTAVVAGAVILRRRNSGGKGGAYVPAADKDSSQGSDVSLIATENLLVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4I5</accession>
    <name>A0A5F8G4I5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Synaptojanin-1</fullName>
            <ecNumber evidence="5">3.1.3.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SYNJ1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.36"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with ASH/GRB2. Interacts with PACSIN1, PACSIN2 and PACSIN3. Interacts with AMPH, SH3GL1, SH3GL2 and SH3GL3. Interacts with MYO1E (via SH3 domain). Interacts with BIN1 and DNM1. Interacts with EPS15.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4I5"/>
    <dbReference type="Ensembl" id="ENSMODT00000088110.1">
        <property type="protein sequence ID" value="ENSMODP00000042388.1"/>
        <property type="gene ID" value="ENSMODG00000021073.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157964"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021073">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000076">
        <property type="entry name" value="Synaptojanin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000003">
        <property type="entry name" value="Synaptojanin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015047">
        <property type="entry name" value="SYNJ1/2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF158">
        <property type="entry name" value="SYNAPTOJANIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08952">
        <property type="entry name" value="DUF1866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01165">
        <property type="entry name" value="DUF1866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAC" evidence="18">
        <location>
            <begin position="119"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1023"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1025"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1036"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1066"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1107"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1138"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1224"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1251"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1272" mass="141177" checksum="454F3138CC19E2BB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4I6</accession>
    <name>A0A5F8G4I6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Structural maintenance of chromosomes protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Chromosome-associated protein E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">XCAP-E homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SMC2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4I6"/>
    <dbReference type="Ensembl" id="ENSMODT00000077302.1">
        <property type="protein sequence ID" value="ENSMODP00000042367.1"/>
        <property type="gene ID" value="ENSMODG00000004036.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074857"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004036">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="22">
        <location>
            <begin position="520"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1109"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="402"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="674"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00075874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1130" mass="127819" checksum="8EC97DE72DE9379B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4I7</accession>
    <name>A0A5F8G4I7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin gamma 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ACTG1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4I7"/>
    <dbReference type="Ensembl" id="ENSMODT00000082731.1">
        <property type="protein sequence ID" value="ENSMODP00000042355.1"/>
        <property type="gene ID" value="ENSMODG00000047420.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182960"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000047420">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000205">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="230" mass="25502" checksum="EC587298CF65F551" modified="2019-12-11" version="1">MFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKVNICIVPNIVFTFNGLLLFLKAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4I9</accession>
    <name>A0A5F8G4I9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Supervillin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SVIL</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4I9"/>
    <dbReference type="Ensembl" id="ENSMODT00000077527.1">
        <property type="protein sequence ID" value="ENSMODP00000042351.1"/>
        <property type="gene ID" value="ENSMODG00000007872.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154653"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007872">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 20 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="298" mass="33926" checksum="28039A74C3C7816C" modified="2019-12-11" version="1">MKRKERIARRLEGIENDSQPILLQSCTGLVTHRLLEEDTPRYTRATDPYSPHIGRSNEEEETSDSSVEKQPRSRYCIETTVLNTESSYSPVTMDTQGLDSKAERIARYKAERRRQLAEKYGLTLDSDADSEYLSRYTKTRKDHDIEKRGSKIEKQEEDNKDLTYHSKIDTAEPRSTILESKDYAFQGNDGVLDKEALLNMENHRRVQELSAIGQIRDLPPAANSSPSFSFSGRDSSFSDVPRSPKQTRRISLSSPKQPASPSHSVTDSLLHGDSRPSHLFYTSSFVLSLCPLLQEFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4J0</accession>
    <name>A0A5F8G4J0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tumor protein D52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TPD52</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPD52 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4J0"/>
    <dbReference type="Ensembl" id="ENSMODT00000064212.1">
        <property type="protein sequence ID" value="ENSMODP00000042393.1"/>
        <property type="gene ID" value="ENSMODG00000006613.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100027042"/>
    <dbReference type="CTD" id="7163"/>
    <dbReference type="GeneTree" id="ENSGT00940000155294"/>
    <dbReference type="OrthoDB" id="6020229at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006613">
        <property type="expression patterns" value="Expressed in endometrium and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007327">
        <property type="entry name" value="TPD52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307:SF12">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04201">
        <property type="entry name" value="TPD52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="353" mass="36579" checksum="32815AE342A9EF93" modified="2019-12-11" version="1">MIRLFPSLPPPLPPPSGGCHFSFQPKPSPPPRRELSLWSASIPAPGPCPSPAASGSVLLLLTAGRSGAECSAQVCRVRWLGDAPGRRSSGGAGLWRRGGWGLSGGGGGGGSGSGDGSGCRSTRGGPSSSPGGCCASLVISAATPGLPTSGARERGANMDSGEPGLLKTDQVPEEGEDAVATISATETLSEEEQEELRKELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELRQNIARGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVNIRSIQHSISMPAMRNSPTFKSFEEKVENLKSKVGGNKAAGGDFGEVLNSTANATATKSLTEQTEETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4J1</accession>
    <name>A0A5F8G4J1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Zinc finger protein 420-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC103096484</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4J1"/>
    <dbReference type="Ensembl" id="ENSMODT00000078008.1">
        <property type="protein sequence ID" value="ENSMODP00000042372.1"/>
        <property type="gene ID" value="ENSMODG00000048003.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155965"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000048003">
        <property type="expression patterns" value="Expressed in spinal cord and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004169">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001890">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002573">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000638">
        <property type="entry name" value="Zinc finger protein 184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001336">
        <property type="entry name" value="Zinc finger protein 334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000044">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000028">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF435">
        <property type="entry name" value="ZINC FINGER PROTEIN 59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="91"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="728"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="86320" checksum="C0A65FFCEEA9CC2D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4J3</accession>
    <name>A0A5F8G4J3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein 536</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF536</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transcriptional repressor that negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription. Binds and interrupts RARA from binding to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="FunCoup" id="A0A5F8G4J3">
        <property type="interactions" value="939"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042359"/>
    <dbReference type="Ensembl" id="ENSMODT00000077083.1">
        <property type="protein sequence ID" value="ENSMODP00000042359.1"/>
        <property type="gene ID" value="ENSMODG00000012653.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156397"/>
    <dbReference type="InParanoid" id="A0A5F8G4J3"/>
    <dbReference type="OMA" id="EKMTQGH"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012653">
        <property type="expression patterns" value="Expressed in cerebellum and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044323">
        <property type="term" value="F:retinoic acid-responsive element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045665">
        <property type="term" value="P:negative regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048387">
        <property type="term" value="P:negative regulation of retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000075">
        <property type="entry name" value="Putative zinc finger protein 536"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000694">
        <property type="entry name" value="zinc finger protein 516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000591">
        <property type="entry name" value="Zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000615">
        <property type="entry name" value="Zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000625">
        <property type="entry name" value="Zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051967">
        <property type="entry name" value="Krueppel_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45925">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45925:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16606">
        <property type="entry name" value="zf-C2H2_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="668"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="861"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="938"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1148"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="861"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="950"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1158"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1175"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1196"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1333" mass="146166" checksum="EFB4C7847807BA00" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4J4</accession>
    <name>A0A5F8G4J4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acetyl-coenzyme A transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Solute carrier family 33 member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC33A1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA(in) = acetyl-CoA(out)</text>
            <dbReference type="Rhea" id="RHEA:75039"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:75040"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SLC33A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4J4"/>
    <dbReference type="Ensembl" id="ENSMODT00000077291.1">
        <property type="protein sequence ID" value="ENSMODP00000042356.1"/>
        <property type="gene ID" value="ENSMODG00000015775.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154019"/>
    <dbReference type="OMA" id="ICTTSWI"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015775">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000287">
        <property type="entry name" value="acetyl-coenzyme A transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="558" mass="62057" checksum="DFC621315513A930" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4J6</accession>
    <name>A0A5F8G4J6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial fission regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MTFR2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MTFR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4J6"/>
    <dbReference type="Ensembl" id="ENSMODT00000071418.1">
        <property type="protein sequence ID" value="ENSMODP00000042365.1"/>
        <property type="gene ID" value="ENSMODG00000017453.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183215"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017453">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007972">
        <property type="entry name" value="Mtfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215">
        <property type="entry name" value="PROTEIN OF UNKNOWN FUNCTION DUF729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05308">
        <property type="entry name" value="Mito_fiss_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="403" mass="45199" checksum="796AED00EEA7AA77" modified="2019-12-11" version="1">MSLMLNLFRQLLEYFGFPLEQFTPIWEAHANGRSIVRVIVTSLPSNLFSRTDLYQICSTILPSWENKEYGSTRSIVRSIGKILPLEPCPRPNFELFQYMKSLDCDQHGSALNPIVPSFADILCVANDEARQDRFRNCIWEKYEDKTQFFNPMPPPLIPLSPVSSQRMQIINGLPVTKAAIKKIAALQDELTILRSQIAAIVALQEAENKFTLESLKSYDIPGNLGPLPSVTSSPSPVPDCSSNSVVHPLPPPPPPPPPPLPPLPPPPPSSPGSNICDSDSSTDRLIKEVHIANKNNTEKYAENQRTKVVPSMMDVLKDMDKVKLRAIERSPGGRPIHKTRREISDWDPVSIISHALKKKFAFQEEDSFEKEDTSWDSSFFSPETPKTLSFLIVRTVYSCSFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4J8</accession>
    <name>A0A5F8G4J8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Spectrin alpha chain, erythrocytic 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Erythroid alpha-spectrin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SPTA1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000084542.1">
        <property type="protein sequence ID" value="ENSMODP00000042377.1"/>
        <property type="gene ID" value="ENSMODG00000010331.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161240"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010331">
        <property type="expression patterns" value="Expressed in blood and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008091">
        <property type="term" value="C:spectrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014731">
        <property type="term" value="C:spectrin-associated cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000007">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000163">
        <property type="entry name" value="spectrin alpha chain, erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000272">
        <property type="entry name" value="Spectrin alpha chain, erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000020">
        <property type="entry name" value="spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000013">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000017">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000020">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000078">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="20">
        <location>
            <begin position="823"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="2115"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="2158"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="887"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1982"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="2036"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="900"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2261" mass="261221" checksum="D2883B1ACF93703C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4K0</accession>
    <name>A0A5F8G4K0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4K0"/>
    <dbReference type="Ensembl" id="ENSMODT00000071253.1">
        <property type="protein sequence ID" value="ENSMODP00000042403.1"/>
        <property type="gene ID" value="ENSMODG00000023472.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164918"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023472">
        <property type="expression patterns" value="Expressed in endometrium and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:005194">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002573">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000292">
        <property type="entry name" value="zinc finger protein 619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001742">
        <property type="entry name" value="Zinc finger protein 620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000350">
        <property type="entry name" value="Zinc finger protein 699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000592">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF15">
        <property type="entry name" value="REDUCED EXPRESSION 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="654"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="709" mass="81526" checksum="9D41753D53773AA3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4K1</accession>
    <name>A0A5F8G4K1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Deubiquitinase MYSM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Myb-like, SWIRM and MPN domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">MYSM1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family. MYSM1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4K1"/>
    <dbReference type="FunCoup" id="A0A5F8G4K1">
        <property type="interactions" value="2568"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042370"/>
    <dbReference type="Ensembl" id="ENSMODT00000088823.1">
        <property type="protein sequence ID" value="ENSMODP00000042370.1"/>
        <property type="gene ID" value="ENSMODG00000003341.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157721"/>
    <dbReference type="InParanoid" id="A0A5F8G4K1"/>
    <dbReference type="OMA" id="QDHYLES"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003341">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140950">
        <property type="term" value="F:histone H2A deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903706">
        <property type="term" value="P:regulation of hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08067">
        <property type="entry name" value="MPN_2A_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000193">
        <property type="entry name" value="histone H2A deubiquitinase MYSM1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000151">
        <property type="entry name" value="histone H2A deubiquitinase MYSM1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000018">
        <property type="entry name" value="histone H2A deubiquitinase MYSM1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH myb-type" evidence="22">
        <location>
            <begin position="137"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="18">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="21">
        <location>
            <begin position="140"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="20">
        <location>
            <begin position="396"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="19">
        <location>
            <begin position="601"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="297"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="855" mass="96034" checksum="963C1C5C7ABBD57F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4K3</accession>
    <name>A0A5F8G4K3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin delta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Delta-tubulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TUBD1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as a positive regulator of hedgehog signaling and regulates ciliary function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003340235.1">
        <property type="nucleotide sequence ID" value="XM_003340187.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4K3"/>
    <dbReference type="Ensembl" id="ENSMODT00000078436.1">
        <property type="protein sequence ID" value="ENSMODP00000042382.1"/>
        <property type="gene ID" value="ENSMODG00000014323.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100010307"/>
    <dbReference type="CTD" id="51174"/>
    <dbReference type="GeneTree" id="ENSGT00940000157069"/>
    <dbReference type="OrthoDB" id="10250004at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014323">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02189">
        <property type="entry name" value="delta_zeta_tubulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000010">
        <property type="entry name" value="Tubulin delta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000021">
        <property type="entry name" value="Tubulin delta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002967">
        <property type="entry name" value="Delta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01224">
        <property type="entry name" value="DELTATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 17" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="18">
        <location>
            <begin position="47"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="398" mass="45042" checksum="3F5BA62A9AA0F6A2" modified="2019-12-11" version="1">MSVVTVQLGQCGNQIGYEVFDTMCRDLHNTQGFCSKRENEIYQASCKEHFFNEDKSEVPVARALLIDMEPKVISQTLLKAAHSGRWKYGQHSHFCQRQGSGNNWAYGYSVHGPKHEESIMNLIQREVEEYDSLSGFSIIMSMAGGTGSGLGAFLTQNLRDAYPNSFIMNQVIWPYGTGEVIVQNYNSVLTLSHLYRSSDALLVHENDVVHKICAKLMNIKQISFRDVNQVIAHQLGSVFQPTYSSEDSFQYRRNPLGIDWQVRPPLSGLPALEKVSPNKELRFNTSIANLLILRGKDVHSADTGGFKDPALYTSWLQPSDAFCEWRTHRAFNKYEKSAALVSNSQFLLKPLDTIVGKAWNMFASKAYVHQYTKFGIEEEDFLDSFTVLEQIVASYCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4K7</accession>
    <name>A0A5F8G4K7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b-c1 complex subunit 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex III subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Core protein I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquinol-cytochrome-c reductase complex core protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">UQCRC1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6. Interacts with STMP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4K7"/>
    <dbReference type="FunCoup" id="A0A5F8G4K7">
        <property type="interactions" value="990"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042371"/>
    <dbReference type="Ensembl" id="ENSMODT00000053655.1">
        <property type="protein sequence ID" value="ENSMODP00000042371.1"/>
        <property type="gene ID" value="ENSMODG00000013475.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158931"/>
    <dbReference type="InParanoid" id="A0A5F8G4K7"/>
    <dbReference type="OMA" id="HFAQGEW"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013475">
        <property type="expression patterns" value="Expressed in heart and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000016">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF116">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="17">
        <location>
            <begin position="88"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="18">
        <location>
            <begin position="241"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="511" mass="56889" checksum="27ED8220232A2007" modified="2019-12-11" version="1">MGGIGEYAHQIISRLWYQEGRVNGSGIVFVGFRMTEVNMARFRVVLITMLFLQPSLLKLPTSRSATTFVQTLQNIPATQVTTLDSGLRVASEDYSRHPTCTVGVWIDVGSRYEHEANNGAAYFVEHLAFKGTKNRPGRALEEEIEKMGAHLNAYTTREHTAYYIKALSKDLPKAVEILGDIVQNCSLEDSQIEKERNVILQEMQESDNSLRDVVFDYLHATAYQGTPLAQAVEGPSENARKLSRQDLTEFIETHYKAPRMVLAAAGDVKHKQLVDLAAKHFSNVPTSYAEDAVPLPSSCRFTGSEIRHRDDALPLAHVAMAVEGPGWANPDNVALLVANSIIGHYDCTYGGGVHQSSPLASVSAANKVCQSFQTFNICYSETGLFGIHFVTDRMNIDDMVFFLQGQWMRLCTSATESDVMRGKNILRNALVSHLDGTTPVCEDIGRSLLTYGRRISLSEWESRISDIDASVIREVCSKYLYDQCPAVAAVGPIEQLPDYNRIRSGMFWLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4K9</accession>
    <name>A0A5F8G4K9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">tRNA wybutosine-synthesizing protein 5</fullName>
            <ecNumber evidence="12">1.14.11.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TYW5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:37899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11848"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73603"/>
            <dbReference type="EC" id="1.14.11.42"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:37900"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TYW5 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.42" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4K9"/>
    <dbReference type="FunCoup" id="A0A5F8G4K9">
        <property type="interactions" value="868"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042413"/>
    <dbReference type="Ensembl" id="ENSMODT00000083154.1">
        <property type="protein sequence ID" value="ENSMODP00000042413.1"/>
        <property type="gene ID" value="ENSMODG00000012381.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158493"/>
    <dbReference type="InParanoid" id="A0A5F8G4K9"/>
    <dbReference type="OMA" id="LYDDRPV"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012381">
        <property type="expression patterns" value="Expressed in placenta and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102524">
        <property type="term" value="F:tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000022">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF104">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="15">
        <location>
            <begin position="124"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="316" mass="37057" checksum="3A67112367D36A4A" modified="2019-12-11" version="1">MFAPNHVLMILNYHIIIHFYYYFGNQQRKPVVLKGIDLGTCTTKWTVDYLSQVGGNKEVKIHVSAVPQMDFISKNFVYRTLPFDKFIQRAAEKKHSTYFISEDEKYYLRSLGEDPRKDIADIRKQFPLLEGDIKIPDFFEKEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRVVLFSPRDAQYLYLSGTKSEVLNLDNPDLSKYPLFFKARRFECVLEAGDVLFIPALWFHNVISEEFGVGVNVFWKHLSSECYDKTDTYGNKDPTAASRAIQILDRALKTLDELPEEYRDFYARRMVLRIQDKAFSSNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4L1</accession>
    <name>A0A5F8G4L1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Zinc finger protein 420-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100616741</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4L1"/>
    <dbReference type="Ensembl" id="ENSMODT00000058335.1">
        <property type="protein sequence ID" value="ENSMODP00000042374.1"/>
        <property type="gene ID" value="ENSMODG00000023579.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153582"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023579">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000629">
        <property type="entry name" value="zinc finger protein 333 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000044">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001437">
        <property type="entry name" value="Zinc finger protein 594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000057">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001333">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="17">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="711"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="84200" checksum="27F31486E858B5B3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVK0</accession>
    <name>A0A5F8GVK0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lysophospholipase</fullName>
            <ecNumber evidence="3">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PNPLA6</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:40808"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49092"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:49093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:15178"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3"/>
    <dbReference type="Ensembl" id="ENSMODT00000053788.1">
        <property type="protein sequence ID" value="ENSMODP00000051384.1"/>
        <property type="gene ID" value="ENSMODG00000015066.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159130"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015066">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd07225">
        <property type="entry name" value="Pat_PNPLA6_PNPLA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000010">
        <property type="entry name" value="neuropathy target esterase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000012">
        <property type="entry name" value="neuropathy target esterase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000001">
        <property type="entry name" value="neuropathy target esterase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000022">
        <property type="entry name" value="Patatin like phospholipase domain containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF26">
        <property type="entry name" value="PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 17" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="170"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="502"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="615"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="21">
        <location>
            <begin position="951"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="351"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="424"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1241"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1278"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="17">
        <location>
            <begin position="955"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="17">
        <location>
            <begin position="982"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="17">
        <location>
            <begin position="1104"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1241"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1283"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1344" mass="150066" checksum="CF11B2D9203AFB56" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVK1</accession>
    <name>A0A5F8GVK1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription and mRNA export factor ENY2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Enhancer of yellow 2 transcription factor homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PKHD1L1</name>
        <name evidence="12" type="synonym">ENY2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
            <location evidence="1 12">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ENY2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVK1"/>
    <dbReference type="Ensembl" id="ENSMODT00000072180.1">
        <property type="protein sequence ID" value="ENSMODP00000051673.1"/>
        <property type="gene ID" value="ENSMODG00000004891.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157594"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004891">
        <property type="expression patterns" value="Expressed in spermatid and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.140:FF:000001">
        <property type="entry name" value="Transcription and mRNA export factor ENY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03046">
        <property type="entry name" value="ENY2_Sus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12514">
        <property type="entry name" value="ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0010">Activator</keyword>
    <keyword evidence="4 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 12" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="116" mass="13209" checksum="48DAEF9B9AEE2B4C" modified="2019-12-11" version="1">MMSTYNISKMNKDAQMRATINQKLIETGERERLKELLRAKLIECGWKDQLKAHCKDVIKEKGLEHVTVDDLVAEITPKGRDGLKMIPKVTEIFPKYGSINGATRLTIKGEGMFPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVK2</accession>
    <name>A0A5F8GVK2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVK2"/>
    <dbReference type="Ensembl" id="ENSMODT00000078341.1">
        <property type="protein sequence ID" value="ENSMODP00000051565.1"/>
        <property type="gene ID" value="ENSMODG00000001323.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160251"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001323">
        <property type="expression patterns" value="Expressed in uterus and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001686">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14947" checksum="ABE98BE0CD44947B" modified="2019-12-11" version="1">MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKVNHRTCLLTFSLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDIFYDLVRQINRKTPVEKKKPKKKSCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVK6</accession>
    <name>A0A5F8GVK6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Complement C4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100025543</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Putative humoral mediator released following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway). While it is strongly similar to anaphylatoxins, its role is unclear. Was reported to act as a mediator of local inflammatory process; however these effects were probably due to contamination with C3a and/C5a anaphylatoxins in biological assays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="FunCoup" id="A0A5F8GVK6">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051678"/>
    <dbReference type="Ensembl" id="ENSMODT00000083290.1">
        <property type="protein sequence ID" value="ENSMODP00000051678.1"/>
        <property type="gene ID" value="ENSMODG00000014979.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155739"/>
    <dbReference type="InParanoid" id="A0A5F8GVK6"/>
    <dbReference type="OMA" id="AANWLTH"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014979">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006956">
        <property type="term" value="P:complement activation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00017">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02896">
        <property type="entry name" value="complement_C3_C4_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000155">
        <property type="entry name" value="complement C3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.690:FF:000002">
        <property type="entry name" value="Complement C4 isoform-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.120:FF:000009">
        <property type="entry name" value="Complement C4-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1540:FF:000001">
        <property type="entry name" value="Complement C4-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000803">
        <property type="entry name" value="Complement C4-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000004">
        <property type="entry name" value="Complement C4-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000007">
        <property type="entry name" value="Complement C4-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000005">
        <property type="entry name" value="complement C4-A isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.20.50.160:FF:000001">
        <property type="entry name" value="Complement component 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1940:FF:000001">
        <property type="entry name" value="Complement component C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1540:FF:000006">
        <property type="entry name" value="MHC-linked complement C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.91.20">
        <property type="entry name" value="Anaphylotoxins (complement system)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000020">
        <property type="entry name" value="Anaphylatoxin/fibulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018081">
        <property type="entry name" value="Anaphylatoxin_comp_syst"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048847">
        <property type="entry name" value="C4_MG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054587">
        <property type="entry name" value="CO4A-B_CUB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF86">
        <property type="entry name" value="COMPLEMENT C4-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01821">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21145">
        <property type="entry name" value="C4_MG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22661">
        <property type="entry name" value="CO4A-B_CUB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00104">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47686">
        <property type="entry name" value="Anaphylotoxins (complement system)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01178">
        <property type="entry name" value="ANAPHYLATOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0765">Sulfation</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023810971" evidence="13">
        <location>
            <begin position="22"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphylatoxin-like" evidence="14">
        <location>
            <begin position="699"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="15">
        <location>
            <begin position="1654"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1135"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1470"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1472"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1487"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1802" mass="198774" checksum="C526CE66D07E4D81" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVK7</accession>
    <name>A0A5F8GVK7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVK7"/>
    <dbReference type="Ensembl" id="ENSMODT00000073073.1">
        <property type="protein sequence ID" value="ENSMODP00000051389.1"/>
        <property type="gene ID" value="ENSMODG00000016493.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183068"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016493">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000074">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18534" checksum="AEE746C458394D4B" modified="2019-12-11" version="1">MATAKEILSTGDSAGRSGRRVHLGIPEAVFLEDVDAFMKQPGNESIDTVLKKLDEQYQKYKFMELNLTQKKRRLKNQIPDIKQTLHILKYMQKKKETTKPLETRFLLADNLYCKAFIPPTDKVCLWLGANVMLEYDINEAQGSLGEESLCCHQQSGILLRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVK8</accession>
    <name>A0A5F8GVK8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Caveolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CAV2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Caveola</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the caveolin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVK8"/>
    <dbReference type="Ensembl" id="ENSMODT00000086122.1">
        <property type="protein sequence ID" value="ENSMODP00000051542.1"/>
        <property type="gene ID" value="ENSMODG00000047495.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183006"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000047495">
        <property type="expression patterns" value="Expressed in heart and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070836">
        <property type="term" value="P:caveola assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001612">
        <property type="entry name" value="Caveolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844:SF3">
        <property type="entry name" value="CAVEOLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01146">
        <property type="entry name" value="Caveolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="119" mass="13467" checksum="F90F3F87C5DC5532" modified="2019-12-11" version="1">MGLETEKADAQIYMDEDSYSRNSGPDYPEPEKCMKSIQDRDPRGLNTHLKMGFEDVIGEPESTHSFDKVWICSHALFEVSKYLIYKVLTVLLAIPLAFVAGILFATLSCLHICKTSDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVK9</accession>
    <name>A0A5F8GVK9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SET domain bifurcated histone lysine methyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SETDB1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVK9"/>
    <dbReference type="Ensembl" id="ENSMODT00000082963.1">
        <property type="protein sequence ID" value="ENSMODP00000051236.1"/>
        <property type="gene ID" value="ENSMODG00000018821.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157471"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018821">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040880">
        <property type="entry name" value="DUF5604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18300">
        <property type="entry name" value="DUF5604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5604" evidence="3">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="250" mass="27610" checksum="12D353CDF071EB1D" modified="2019-12-11" version="1">MTSFPGCFGLGTAAAAGMEPQEIAELQQAVVEELGISMEELRQFIDEELEKMDCVKQRKKQLAELETWVVQKESEVAHVDQLFDEASRAVTNCESLVKDFYSKLGLQYRESSSEDEASKPTEVIEIPDEDDDVLSVDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKTSSQDLSKGALGQVPIELSKDGDLVVNMRILGKKRTKTWHKGTLIAIQTVDSSSSLMMATHPMSHSLSSIPFVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVL1</accession>
    <name>A0A5F8GVL1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ring finger protein, transmembrane 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RNFT2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVL1"/>
    <dbReference type="Ensembl" id="ENSMODT00000065153.1">
        <property type="protein sequence ID" value="ENSMODP00000051394.1"/>
        <property type="gene ID" value="ENSMODG00000015400.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158419"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015400">
        <property type="expression patterns" value="Expressed in spinal cord and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044235">
        <property type="entry name" value="RNFT1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860:SF2">
        <property type="entry name" value="RING FINGER AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860">
        <property type="entry name" value="UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="182"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="242" mass="27675" checksum="2EE5EEAA40889BCC" modified="2019-12-11" version="1">CLAQNPKEKRSVLVIFWILAFLVGNTLYVLYTFSSQQLYNSLIFLKPNLDSLDFFDLLWIVGIADFMLKYITIALKCLIVALPKIILAVKSKGKFYLVIEELSQLFRSLVPIQLWYKYIMGDDPSNSYFLGGILIILYSLCKSFDICGRLGGVRKALKLFCTPQNYGARATSQQCAEAGEICAICQAEFREPLVLMCQHVFCEECLCLWFDRERTCPLCRSVAVETLRCWKDGTTSAHFQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVL2</accession>
    <name>A0A5F8GVL2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alanine--glyoxylate aminotransferase 2, mitochondrial</fullName>
            <ecNumber evidence="29">2.6.1.18</ecNumber>
            <ecNumber evidence="13">2.6.1.40</ecNumber>
            <ecNumber evidence="5">2.6.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">(R)-3-amino-2-methylpropionate--pyruvate transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Beta-ALAAT II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Beta-alanine-pyruvate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">D-3-aminoisobutyrate-pyruvate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">D-AIBAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">D-beta-aminoisobutyrate-pyruvate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="41" type="primary">AGXT2</name>
    </gene>
    <organism evidence="41 42">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="41 42" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="41" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="41" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="39">Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77339"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:18393"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57731"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.40"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:18394"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:77355"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate</text>
            <dbReference type="Rhea" id="RHEA:77363"/>
            <dbReference type="ChEBI" id="CHEBI:35177"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:58455"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate</text>
            <dbReference type="Rhea" id="RHEA:77359"/>
            <dbReference type="ChEBI" id="CHEBI:28644"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:58441"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>3-oxopropanoate + L-alanine = beta-alanine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:14077"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.18"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:14079"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77331"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58802"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77327"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58802"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77315"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:197308"/>
            <dbReference type="ChEBI" id="CHEBI:197310"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77307"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:197308"/>
            <dbReference type="ChEBI" id="CHEBI:197310"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate</text>
            <dbReference type="Rhea" id="RHEA:77351"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77311"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:77343"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77303"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77323"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
            <dbReference type="ChEBI" id="CHEBI:197314"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77319"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
            <dbReference type="ChEBI" id="CHEBI:197314"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glyoxylate + L-alanine = glycine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:24248"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:24249"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>oxaloacetate + L-alanine = L-aspartate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:77347"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 40">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.18" evidence="29"/>
    <dbReference type="EC" id="2.6.1.40" evidence="13"/>
    <dbReference type="EC" id="2.6.1.44" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVL2"/>
    <dbReference type="Ensembl" id="ENSMODT00000084641.1">
        <property type="protein sequence ID" value="ENSMODP00000051683.1"/>
        <property type="gene ID" value="ENSMODG00000020379.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156125"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020379">
        <property type="expression patterns" value="Expressed in kidney and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047305">
        <property type="term" value="F:(R)-3-amino-2-methylpropionate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016223">
        <property type="term" value="F:beta-alanine:pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000055">
        <property type="entry name" value="Alanine--glyoxylate aminotransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000105">
        <property type="entry name" value="alanine--glyoxylate aminotransferase 2, mitochondrial isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF3">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 40" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="42" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00043749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00043758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00043777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00043798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00043825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00043826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00044055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00044257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00044258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00047892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00049480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00058068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="474" mass="52656" checksum="4DF71B3C91ED90BD" modified="2019-12-11" version="1">MALLKVSFLQMSKRCLQQHGGVCWKLGSKLSVHTPPKMPPCDFTPERYESLPYNQILEIRKQNFSPQMSTYFQKPLLLHQGYMQWLFDYEGKRYLDLFSGIVTVSVGHCHPRVTTAAQNQFGRLWHTSPVFLHPAIHEYAEKLTALLPEPLKVVYFTNSGSEANDLAMMMARSHSQNVDIISFRGAYHGASPSTLGLTSVGAFKPRTTTGSNCQTTMCPDVFRGPWGGSQCRDSLVQTIRKCSCAPGCCEANSQYIEQFKNTLHTVVAKEIAGFFAEPIQGVNGVVQYPKGFLKEAFQLVRERGGVCIADEVQTGFGRLGTHFWGFQSHGVLPDIVTMAKGIANGFPMSAVVTTPEIAKSLTKSMNFFNTFSGNPIAGVIASAVLDAIKEDGLQENSQETGSYLLLKLAKLQNEFEIIGDVRGKGLMIGVEMVQDQTFRIAPPMCITKEEADFAVEVFHSVLRRHMEKRAKEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVL3</accession>
    <name>A0A5F8GVL3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein kinase DCLK2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CaMK-like CREB regulatory kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Doublecortin-like and CAM kinase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Doublecortin-like kinase 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="Ensembl" id="ENSMODT00000067709.1">
        <property type="protein sequence ID" value="ENSMODP00000051547.1"/>
        <property type="gene ID" value="ENSMODG00000000868.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154895"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000868">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17069">
        <property type="entry name" value="DCX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000066">
        <property type="entry name" value="Serine/threonine-protein kinase DCLK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000057">
        <property type="entry name" value="Serine/threonine-protein kinase DCLK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000001">
        <property type="entry name" value="serine/threonine-protein kinase DCLK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000002">
        <property type="entry name" value="serine/threonine-protein kinase DCLK2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Doublecortin" evidence="22">
        <location>
            <begin position="72"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="22">
        <location>
            <begin position="1074"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="1258"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1171"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1202"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1506" mass="166212" checksum="D326A59C68D325AD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVL4</accession>
    <name>A0A5F8GVL4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Tenascin C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TNC</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tenascin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000069197.1">
        <property type="protein sequence ID" value="ENSMODP00000051241.1"/>
        <property type="gene ID" value="ENSMODG00000019592.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155188"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019592">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000099">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000001">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000162">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000201">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000207">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000274">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000293">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000398">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000529">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000611">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041161">
        <property type="entry name" value="EGF_Tenascin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF1">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18720">
        <property type="entry name" value="EGF_Tenascin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023844473" evidence="13">
        <location>
            <begin position="23"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="624"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="804"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="896"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="986"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1075"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1166"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1258"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1348"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1438"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1525"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="16">
        <location>
            <begin position="1611"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1837" mass="201843" checksum="ADDDA4BF37D2F855" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVL8</accession>
    <name>A0A5F8GVL8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100023235</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVL8"/>
    <dbReference type="Ensembl" id="ENSMODT00000081532.1">
        <property type="protein sequence ID" value="ENSMODP00000051688.1"/>
        <property type="gene ID" value="ENSMODG00000005516.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155736"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005516">
        <property type="expression patterns" value="Expressed in liver and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd20665">
        <property type="entry name" value="CYP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000299">
        <property type="entry name" value="Cytochrome P450 2C9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF400">
        <property type="entry name" value="CYTOCHROME P450 2C9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="486" mass="55730" checksum="83FD5BBA2706E540" modified="2019-12-11" version="1">MPIFQVINNGLAWKKDFRRGKLPPGPVPFPIIGNILQLDLKNIPESLCKLAKEYGPVFTLQLGFTRTVVLHGYKAVKEALIDHGDQFAARGHMPVFEFISQGLGIVSSNGERWKQLRRFSLMTLRNFGMGKKSIEENVQEEAKLLVEAIKQTKGLPCDPTFILGCAPCNVICSLIFQKHFEYKDPKFLYLMKLLDDDLKLLSSPWIQVYNYFSPLIHYLPGLHHKLFKITDLQKKFILEEVKEHQQTLDPNNIRDFIDCFLMKMEQEKQKPLSEFTIGNLVNTAIDLFAAGTETTSTTLKYGFLMLLKHPEITEKIHEEIDRVIGYNRSPCMEDRNKVPYTNAVVHEIQRYIDHIPTSLPHAVTEDVQFRQYLIPKGTTIIPLLTSVLYDDEEFPNPHQFDPGHFLDASGNFKKSDYFMPFSTGKRICLGEGLARMELFLFFTTILQNFTLKSLIDPKDIDTTPIDSGFGKIPPSYKLCFLPSQNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVL9</accession>
    <name>A0A5F8GVL9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tropomyosin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TPM1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVL9"/>
    <dbReference type="Ensembl" id="ENSMODT00000059940.1">
        <property type="protein sequence ID" value="ENSMODP00000051246.1"/>
        <property type="gene ID" value="ENSMODG00000039857.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234542"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000039857">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000005">
        <property type="entry name" value="Tropomyosin alpha-1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="245" mass="28377" checksum="8B58AD76A7810329" modified="2019-12-11" version="1">MAGISSLEAVRRKIRSLQEQADSAEERAGSLQRELDQERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDQLYQQLEQNRRLTNELKLALNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVM1</accession>
    <name>A0A5F8GVM1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase COP1</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Constitutive photomorphogenesis protein 1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING finger and WD repeat domain protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">RING-type E3 ubiquitin transferase RFWD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">COP1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the COP1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVM1"/>
    <dbReference type="Ensembl" id="ENSMODT00000063083.1">
        <property type="protein sequence ID" value="ENSMODP00000051557.1"/>
        <property type="gene ID" value="ENSMODG00000005579.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00920000149161"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005579">
        <property type="expression patterns" value="Expressed in hindlimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16504">
        <property type="entry name" value="RING-HC_COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000222">
        <property type="entry name" value="E3 ubiquitin-protein ligase COP1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000090">
        <property type="entry name" value="E3 ubiquitin-protein ligase RFWD2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 22" id="KW-0853">WD repeat</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="25">
        <location>
            <begin position="146"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="496"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="582"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="24">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00079529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00080543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="718" mass="78063" checksum="56CE201FC0A25C36" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVM2</accession>
    <name>A0A5F8GVM2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family with sequence similarity 124 member A</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM124 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVM2"/>
    <dbReference type="FunCoup" id="A0A5F8GVM2">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051404"/>
    <dbReference type="Ensembl" id="ENSMODT00000060674.1">
        <property type="protein sequence ID" value="ENSMODP00000051404.1"/>
        <property type="gene ID" value="ENSMODG00000010734.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00590000083134"/>
    <dbReference type="InParanoid" id="A0A5F8GVM2"/>
    <dbReference type="OMA" id="DVRWQTE"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010734">
        <property type="expression patterns" value="Expressed in cerebellum and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029380">
        <property type="entry name" value="FAM124"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046365">
        <property type="entry name" value="FAM124_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14715">
        <property type="entry name" value="FAM124 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14715:SF4">
        <property type="entry name" value="PROTEIN FAM124A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15067">
        <property type="entry name" value="FAM124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM124" evidence="3">
        <location>
            <begin position="67"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="567" mass="63013" checksum="F66B349BB5078699" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVM5</accession>
    <name>A0A5F8GVM5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="9">PARP</shortName>
            <ecNumber evidence="9">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PARP11</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVM5"/>
    <dbReference type="Ensembl" id="ENSMODT00000079033.1">
        <property type="protein sequence ID" value="ENSMODP00000051590.1"/>
        <property type="gene ID" value="ENSMODG00000018324.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156857"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018324">
        <property type="expression patterns" value="Expressed in spermatid and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000003">
        <property type="entry name" value="TCDD-inducible poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF4">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="2 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="10">
        <location>
            <begin position="42"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="257" mass="30063" checksum="A43AAD05257452F4" modified="2019-12-11" version="1">MWEVAYVSVMKQMNLTTGKQRSIKRAPFSITAFSYICENEAIPVPSHWENVNTEEPYQLIPLHKQTNEYNEVASLFGKTVDSNRIKRIQRIQNLDLWEFFCRKKAQLKKKRGVPKINEQMLFHGTSSEFVEAICIHNFDWRINGIHAAVFGKGTYFARDAAYSSRFCKDDMKHGTTFQIHGVSLQQRHLFRTYKSMFLARVLIGDYINGDSKYMRPPSKDGSFVNLYDSCVDNTWNPKIFVVFDANQIYPEYLIEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVM8</accession>
    <name>A0A5F8GVM8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 6 member 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLC6A20</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVM8"/>
    <dbReference type="Ensembl" id="ENSMODT00000063711.1">
        <property type="protein sequence ID" value="ENSMODP00000051698.1"/>
        <property type="gene ID" value="ENSMODG00000011369.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155873"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011369">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002438">
        <property type="entry name" value="Neutral_aa_SLC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF44">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01206">
        <property type="entry name" value="ORPHTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="618" mass="69150" checksum="7FDF2B7FFA3B025B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVN1</accession>
    <name>A0A5F8GVN1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiosis-specific coiled-coil domain-containing protein MEIOC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC103106895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007499829.1">
        <property type="nucleotide sequence ID" value="XM_007499767.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVN1"/>
    <dbReference type="Ensembl" id="ENSMODT00000087110.1">
        <property type="protein sequence ID" value="ENSMODP00000051567.1"/>
        <property type="gene ID" value="ENSMODG00000027446.2"/>
    </dbReference>
    <dbReference type="GeneID" id="103106895"/>
    <dbReference type="GeneTree" id="ENSGT00390000003267"/>
    <dbReference type="OrthoDB" id="9447195at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000027446">
        <property type="expression patterns" value="Expressed in uterus and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027963">
        <property type="entry name" value="MEIOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33861:SF4">
        <property type="entry name" value="MEIOSIS-SPECIFIC COILED-COIL DOMAIN-CONTAINING PROTEIN MEIOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33861">
        <property type="entry name" value="PROTEIN CBG18333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15189">
        <property type="entry name" value="MEIOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="917" mass="103456" checksum="89B86FFF07CB55FC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVN2</accession>
    <name>A0A5F8GVN2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVN2"/>
    <dbReference type="Ensembl" id="ENSMODT00000086918.1">
        <property type="protein sequence ID" value="ENSMODP00000051414.1"/>
        <property type="gene ID" value="ENSMODG00000050187.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000050187">
        <property type="expression patterns" value="Expressed in spermatid and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="16"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="105"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="192"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="281"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="368"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="457"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="544"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="633"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="720"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="809"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="906" mass="98713" checksum="07998C8C61C0C295" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVN3</accession>
    <name>A0A5F8GVN3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SLC1A4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVN3"/>
    <dbReference type="Ensembl" id="ENSMODT00000074643.1">
        <property type="protein sequence ID" value="ENSMODP00000051703.1"/>
        <property type="gene ID" value="ENSMODG00000003310.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157081"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003310">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3860.10:FF:000005">
        <property type="entry name" value="Amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF20">
        <property type="entry name" value="NEUTRAL AMINO ACID TRANSPORTER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0769">Symport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="518" mass="54696" checksum="369915671357738D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVN4</accession>
    <name>A0A5F8GVN4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromosome 1 open reading frame 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">C1orf43</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVN4"/>
    <dbReference type="Ensembl" id="ENSMODT00000088653.1">
        <property type="protein sequence ID" value="ENSMODP00000051261.1"/>
        <property type="gene ID" value="ENSMODG00000017237.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047366"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017237">
        <property type="expression patterns" value="Expressed in uterus and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010876">
        <property type="entry name" value="C1orf43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425:SF2">
        <property type="entry name" value="PROTEIN C1ORF43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07406">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="236" mass="26657" checksum="F44880FD75B895FF" modified="2019-12-11" version="1">MASSSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSKVQDVKYEPKLLEEDDARLLQLETPGNQQIPFHSEGRHPRSLMGKNFRSYLLELRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGQTEYLHYQEALSELAAAVKARGGNSQRQHQSAAKDLTQSPEVSSPTTIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVN5</accession>
    <name>A0A5F8GVN5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynamin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Scaffold protein Tuba</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">DNMBP</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_016280450.1">
        <property type="nucleotide sequence ID" value="XM_016424964.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVN5"/>
    <dbReference type="Ensembl" id="ENSMODT00000067767.1">
        <property type="protein sequence ID" value="ENSMODP00000051572.1"/>
        <property type="gene ID" value="ENSMODG00000003273.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100015477"/>
    <dbReference type="CTD" id="23268"/>
    <dbReference type="GeneTree" id="ENSGT00950000183088"/>
    <dbReference type="OMA" id="REGEKWY"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003273">
        <property type="expression patterns" value="Expressed in ovary and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07589">
        <property type="entry name" value="BAR_DNMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11798">
        <property type="entry name" value="SH3_DNMBP_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12141">
        <property type="entry name" value="SH3_DNMBP_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000027">
        <property type="entry name" value="dynamin-binding protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000066">
        <property type="entry name" value="dynamin-binding protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000084">
        <property type="entry name" value="dynamin-binding protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000023">
        <property type="entry name" value="dynamin-binding protein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035820">
        <property type="entry name" value="DNMBP_SH3_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF19">
        <property type="entry name" value="DYNAMIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="DH" evidence="18">
        <location>
            <begin position="363"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="19">
        <location>
            <begin position="587"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="864"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="1097"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="927"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="955"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="981"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1161" mass="134203" checksum="160F142177E670E6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVN6</accession>
    <name>A0A5F8GVN6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MIA SH3 domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MIA</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIA/OTOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVN6"/>
    <dbReference type="FunCoup" id="A0A5F8GVN6">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000066043.1">
        <property type="protein sequence ID" value="ENSMODP00000051600.1"/>
        <property type="gene ID" value="ENSMODG00000043752.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182767"/>
    <dbReference type="InParanoid" id="A0A5F8GVN6"/>
    <dbReference type="OMA" id="VVQENQY"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000043752">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000175">
        <property type="entry name" value="Melanoma-derived growth regulatory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043369">
        <property type="entry name" value="MIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47312">
        <property type="entry name" value="MELANOMA-DERIVED GROWTH REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47312:SF1">
        <property type="entry name" value="MELANOMA-DERIVED GROWTH REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023825740" evidence="8">
        <location>
            <begin position="25"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="44"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="142" mass="15279" checksum="A628AE995EFA0388" modified="2019-12-11" version="1">MIWTPASLLLATIILSSFPNLGDGGRPMAKLASRKLCADEECSYPISQAVALQDYSAPDCRFLSVQQGQVVFVYSKLMGRGRLFWGGSVQGEYYGSQPARLGYFPSSILREDHVLKPGKVEVKTDVSALPPSSCPSPLPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVN7</accession>
    <name>A0A5F8GVN7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Erlin</fullName>
            <shortName evidence="15">SPFH domain-containing protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endoplasmic reticulum lipid raft-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Stomatin-prohibitin-flotillin-HflC/K domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ERLIN2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Interacts with SCAP, INSIG1, SREBF1 and SREBF2 under cholesterol sufficiency conditions; indicative for an association with the SCAP-SREBP-INSIG complex. Probably part of an AMFR/gp78 and INSIG1-containing ubiquitin ligase complex involved in ERAD of HMGCR. Interacts with TMUB1; TMUB1 bridges the association with AMFR. Interacts with SYVN1 and RNF139. Interacts with TMEM259. Interacts with TMEM41B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVN7"/>
    <dbReference type="Ensembl" id="ENSMODT00000079038.1">
        <property type="protein sequence ID" value="ENSMODP00000051419.1"/>
        <property type="gene ID" value="ENSMODG00000010889.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014666"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010889">
        <property type="expression patterns" value="Expressed in heart and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045541">
        <property type="term" value="P:negative regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03406">
        <property type="entry name" value="SPFH_like_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000009">
        <property type="entry name" value="Erlin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033294">
        <property type="entry name" value="Erlin1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15351">
        <property type="entry name" value="ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15351:SF4">
        <property type="entry name" value="ERLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="12 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023841290" description="Erlin" evidence="16">
        <location>
            <begin position="26"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="17">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="308" mass="34312" checksum="D16BF714C8AB1BA1" modified="2019-12-11" version="1">MAQVGAVVAVATSFFCAALFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLISNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIDAAFLAREKAKADAECYTALKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDTAGNLAKQFEGQAEDLGSNIEDNWGVATEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVN8</accession>
    <name>A0A5F8GVN8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane p24 trafficking protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMED9</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVN8"/>
    <dbReference type="Ensembl" id="ENSMODT00000070337.1">
        <property type="protein sequence ID" value="ENSMODP00000051708.1"/>
        <property type="gene ID" value="ENSMODG00000046290.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159747"/>
    <dbReference type="OMA" id="GATCAWQ"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000046290">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="197" mass="23143" checksum="124FD68A87830C61" modified="2025-10-08" version="2">MVQNYYFINIGNISELLCPFLRAGNYRTQLYDKQREEYQPATPGLGMFVEVKDPDDKVILSRQYGSEGRFTFTSHTPGEHQICLHSNSTKFSLFAGGMLRVHLDIQVGEHANDYAEIAAKDKLSELQLRVRQLVEQVEQIQKEQNYQRWREERFRQTSESTNQRVLWWSIVQTLILVAIGVWQMRHLKSFFEAKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GW00</accession>
    <name>A0A5F8GW00_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Striatin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">STRN3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Tetramerizes. Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26. The STRIPAK complex can be extended by adapter proteins such as SLMAP:SIKE1 or CTTNBP2NL. Interacts with CDC42BPB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056666406.1">
        <property type="nucleotide sequence ID" value="XM_056810428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GW00"/>
    <dbReference type="Ensembl" id="ENSMODT00000055242.1">
        <property type="protein sequence ID" value="ENSMODP00000051544.1"/>
        <property type="gene ID" value="ENSMODG00000017571.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013033"/>
    <dbReference type="CTD" id="29966"/>
    <dbReference type="GeneTree" id="ENSGT00950000183095"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017571">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.300:FF:000001">
        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000616">
        <property type="entry name" value="Striatin-3 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000110">
        <property type="entry name" value="striatin-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000134">
        <property type="entry name" value="striatin-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF3">
        <property type="entry name" value="STRIATIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="18">
        <location>
            <begin position="67"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="549"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="686"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="764" mass="83507" checksum="481B638B6EA8D486" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7J7</accession>
    <name>A0A5F8H7J7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1 open reading frame, human C16orf95</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7J7"/>
    <dbReference type="Ensembl" id="ENSMODT00000064613.1">
        <property type="protein sequence ID" value="ENSMODP00000055201.1"/>
        <property type="gene ID" value="ENSMODG00000045409.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003910"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000045409">
        <property type="expression patterns" value="Expressed in spermatid and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027919">
        <property type="entry name" value="DUF4568"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14693">
        <property type="entry name" value="RIKEN CDNA 1700018B08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14693:SF0">
        <property type="entry name" value="RIKEN CDNA 1700018B08 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15132">
        <property type="entry name" value="DUF4568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="429" mass="49930" checksum="EE0B75CE062AB199" modified="2019-12-11" version="1">MAPGKRTFEHRELNWNPEVNKSILRNKHLQDLKADVTFVDFKDPSCYGNLSHLVPECCHCYFRPHDFGGFLPVPRNEANFPYWVPRSLRSQKPVHRKVRFSVPENLKTCTCPCHSFGGHLPVPREFAPFPYWVPQSIRLLGKIKKNSASPMWTKGNFYVDNQLYYHYKHWRVCCDDIQLSKWQKIQAIIPQPITSWAIVEEEECVVPFVSPWVFFSCFYNLMTALISALRGGATNNSVKIIEDIVPEMRSLEERKEVSETEELKEMRAKEKEKRKEERIRVMRILATSAGDCKREEEAKMEQLFQTDDEFEHYDPEDINGTFIRSKKKASGMDNERKESKRKEGLASGIQGVASECLPHFHGCWRVCSEGSRLDMLLNLQSQFRDEASKRPYMLYKQPDEERTLPVFVLGIVLGSIRSVASAMRYFWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7J8</accession>
    <name>A0A5F8H7J8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein enabled homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ENAH</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Ena/VASP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7J8"/>
    <dbReference type="Ensembl" id="ENSMODT00000083757.1">
        <property type="protein sequence ID" value="ENSMODP00000055519.1"/>
        <property type="gene ID" value="ENSMODG00000005856.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157376"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005856">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01207">
        <property type="entry name" value="EVH1_Ena_VASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22185">
        <property type="entry name" value="WH2_hVASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000003">
        <property type="entry name" value="protein enabled homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000047">
        <property type="entry name" value="vasodilator-stimulated phosphoprotein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038023">
        <property type="entry name" value="VASP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014885">
        <property type="entry name" value="VASP_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF1">
        <property type="entry name" value="PROTEIN ENABLED HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08776">
        <property type="entry name" value="VASP_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118370">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="WH1" evidence="20">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="127"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="325"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="610"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="145"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="538"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="799" mass="86501" checksum="CE2C271A82E0C5F0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7J9</accession>
    <name>A0A5F8H7J9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kelch-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KLHL3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Component of the BCR(KLHL3) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL3 and RBX1. Interacts with CLDN8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KLHL3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7J9"/>
    <dbReference type="Ensembl" id="ENSMODT00000074307.1">
        <property type="protein sequence ID" value="ENSMODP00000055777.1"/>
        <property type="gene ID" value="ENSMODG00000014989.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157891"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014989">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18513">
        <property type="entry name" value="BACK_KLHL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18339">
        <property type="entry name" value="BTB_POZ_KLHL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000002">
        <property type="entry name" value="Kelch-like family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030578">
        <property type="entry name" value="KLHL3_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF179">
        <property type="entry name" value="KELCH-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="50"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="535" mass="59553" checksum="A6E0CEA3920B9E48" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7K0</accession>
    <name>A0A5F8H7K0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">WD repeat and FYVE domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">WDFY3</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_016278552.1">
        <property type="nucleotide sequence ID" value="XM_016423066.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000077327.1">
        <property type="protein sequence ID" value="ENSMODP00000055923.1"/>
        <property type="gene ID" value="ENSMODG00000020782.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100014537"/>
    <dbReference type="CTD" id="23001"/>
    <dbReference type="GeneTree" id="ENSGT00940000155680"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020782">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15719">
        <property type="entry name" value="FYVE_WDFY3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000028">
        <property type="entry name" value="Putative hepatocyte growth factor-regulated tyrosine kinase substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000095">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000293">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF1">
        <property type="entry name" value="WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0072">Autophagy</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="15" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 21" id="KW-0853">WD repeat</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="25">
        <location>
            <begin position="2513"/>
            <end position="2638"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="24">
        <location>
            <begin position="2665"/>
            <end position="2958"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="3105"/>
            <end position="3146"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="23">
        <location>
            <begin position="3436"/>
            <end position="3496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="790"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="2442"/>
            <end position="2505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="2953"/>
            <end position="2974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="3253"/>
            <end position="3294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="2450"/>
            <end position="2459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="2953"/>
            <end position="2962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="3260"/>
            <end position="3272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00069628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="3508" mass="393485" checksum="35594202FAEFDA80" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7K1</accession>
    <name>A0A5F8H7K1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Talin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TLN2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7K1"/>
    <dbReference type="Ensembl" id="ENSMODT00000069495.1">
        <property type="protein sequence ID" value="ENSMODP00000055206.1"/>
        <property type="gene ID" value="ENSMODG00000011273.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154699"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011273">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12150">
        <property type="entry name" value="talin-RS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.10:FF:000005">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037438">
        <property type="entry name" value="Talin1/2-RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054060">
        <property type="entry name" value="TLN1-like_RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015009">
        <property type="entry name" value="Vinculin-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF34">
        <property type="entry name" value="TALIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21865">
        <property type="entry name" value="TLN1-like_RS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08913">
        <property type="entry name" value="VBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Talin 1-like rod-segment" evidence="4">
        <location>
            <begin position="52"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Vinculin-binding site-containing" evidence="3">
        <location>
            <begin position="243"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="323" mass="34539" checksum="9362406EA3EE0FEE" modified="2019-12-11" version="1">MLESSSFLIRTARSLAINPKDPPTWSVLAGHSHTVSDSIKSLITSIRDKAPGQRECDYSIDGINRCIRDIEQASLAAVSQNLATRDDISVEALQEQLTSVVQEIGHLIDPIATAARGEAAQLGHKVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQMLYAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGMVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAITAQEMMTKSVTNPEELGGLASQMTSDYGHLALQGQMAAATAEPEEVCHLKTSILTSECTLMFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7K2</accession>
    <name>A0A5F8H7K2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase MRCK alpha</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">CDC42-binding protein kinase alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">CDC42BPA</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="Ensembl" id="ENSMODT00000079800.1">
        <property type="protein sequence ID" value="ENSMODP00000055524.1"/>
        <property type="gene ID" value="ENSMODG00000006246.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234517"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006246">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20864">
        <property type="entry name" value="C1_MRCKalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01243">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000014">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000010">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000032">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001055">
        <property type="entry name" value="Serine/threonine-protein kinase MRCK beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031597">
        <property type="entry name" value="KELK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014930">
        <property type="entry name" value="Myotonic_dystrophy_kinase_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF31">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MRCK ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08826">
        <property type="entry name" value="DMPK_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15796">
        <property type="entry name" value="KELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="16 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="77"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="30">
        <location>
            <begin position="344"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="27">
        <location>
            <begin position="1004"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="25">
        <location>
            <begin position="1074"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="29">
        <location>
            <begin position="1219"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="28">
        <location>
            <begin position="1563"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1626"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="441"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="701"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="886"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1626"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1644"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1679"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1701"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1715"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1751" mass="199327" checksum="7CB1573DAFD23809" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7K4</accession>
    <name>A0A5F8H7K4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 420-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100617161</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7K4"/>
    <dbReference type="Ensembl" id="ENSMODT00000062975.1">
        <property type="protein sequence ID" value="ENSMODP00000055928.1"/>
        <property type="gene ID" value="ENSMODG00000051396.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155965"/>
    <dbReference type="OMA" id="NESMECG"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000051396">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003515">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004106">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002573">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001178">
        <property type="entry name" value="zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001700">
        <property type="entry name" value="Zinc finger protein 677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="38"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="701" mass="80907" checksum="D17CA46D5FDD1482" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7K5</accession>
    <name>A0A5F8H7K5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Homeobox-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">HMBOX1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Associates with the telomerase holoenzyme complex. Interacts with DKC1, XRCC6 and COIL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7K5"/>
    <dbReference type="Ensembl" id="ENSMODT00000058673.1">
        <property type="protein sequence ID" value="ENSMODP00000055529.1"/>
        <property type="gene ID" value="ENSMODG00000008788.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154928"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008788">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000038">
        <property type="entry name" value="Homeobox-containing protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000011">
        <property type="entry name" value="homeobox-containing protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040363">
        <property type="entry name" value="HMBOX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006899">
        <property type="entry name" value="HNF-1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044869">
        <property type="entry name" value="HNF-1_POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044866">
        <property type="entry name" value="HNF_P1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14618:SF0">
        <property type="entry name" value="HOMEOBOX-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14618">
        <property type="entry name" value="HOMEODOX-CONTAINING PROTEIN 1 HMBOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04814">
        <property type="entry name" value="HNF-1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51937">
        <property type="entry name" value="HNF_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51936">
        <property type="entry name" value="POU_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 19 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 19 20" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15 19 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0779">Telomere</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="HNF-p1" evidence="24">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="POU-specific atypical" evidence="23">
        <location>
            <begin position="145"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="22">
        <location>
            <begin position="265"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="19">
        <location>
            <begin position="267"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="56"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="353"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="406" mass="46117" checksum="87277DFCF748C088" modified="2019-12-11" version="1">MLSSFPVVLLETMSHYTDEPRFTIEQIDLLQRLRRTGMTKHEILHALETLDRLDQEHNDKFGRRPSYGGGSYGNNTNNVPASSSTATASTQTQHSGMSPSPSNSYDTSPQPCTTNQNGRESNERLSTSNGKMSPTRYHANSMGQRSYSFEASEEDLDVDDKVEELMRRDSSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQKKRAFYRWYQLEKTNPGATLSMRPAPIPVEDPEWRQTPPPVTATSGTFRLRRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNAVIQKPGKKLSDLERVTSLKVYNWFANRRKEIKRRANIEAAILESHGIDVQSPGGHSNSDDVDGNDYSEQDTWQVRNGEEEEGRSSEGGREAEKVEEERRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7K6</accession>
    <name>A0A5F8H7K6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
            <ecNumber evidence="2">3.2.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BST1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.6" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7K6"/>
    <dbReference type="Ensembl" id="ENSMODT00000082124.1">
        <property type="protein sequence ID" value="ENSMODP00000055211.1"/>
        <property type="gene ID" value="ENSMODG00000001017.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017291"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001017">
        <property type="expression patterns" value="Expressed in lung and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04759">
        <property type="entry name" value="Rib_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.82.10">
        <property type="entry name" value="ADP Ribosyl Cyclase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003193">
        <property type="entry name" value="ADP-ribosyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912:SF4">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02267">
        <property type="entry name" value="Rib_hydrolayse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="329" mass="37619" checksum="B21E29CFB490F298" modified="2019-12-11" version="1">MQELQFLGATGCKPHCREEILRARNSSMEPSKLVLLQLKLFLILLLGAAGVCMGAGEKLWKGLGTTPHLESIFRGRCNEFISLENPELGDKNCSEIWEAFKTVFHKDPCSVLPSDYDLFINLSRHPIPRDKSLFWENNYDVVTAYAQNGRRLLPITNMLYGRIVDLLDWCRKENSSELDYQSCPTTEDCENNAMDSFWKKASSQYAYDSSGVIYVMLNGSEPSGAYPVKGFFADYEIPNFQKDKVTRFVIWVMHEIGQPHIESCGEGSMKILENRLKEMEFKYECINDYRAAESTQQRIPFLFGGGWGSSLAFLLFFFGINFRNSILTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7K7</accession>
    <name>A0A5F8H7K7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="21">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ACVR1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18673"/>
            <dbReference type="Rhea" id="RHEA-COMP:11022"/>
            <dbReference type="Rhea" id="RHEA-COMP:11023"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 21">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="21">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21">Membrane</location>
            <topology evidence="1 21">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="21"/>
    <dbReference type="RefSeq" id="XP_056649864.1">
        <property type="nucleotide sequence ID" value="XM_056793886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7K7"/>
    <dbReference type="Ensembl" id="ENSMODT00000068941.1">
        <property type="protein sequence ID" value="ENSMODP00000055787.1"/>
        <property type="gene ID" value="ENSMODG00000004431.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100021438"/>
    <dbReference type="CTD" id="90"/>
    <dbReference type="GeneTree" id="ENSGT00940000160160"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004431">
        <property type="expression patterns" value="Expressed in lung and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032924">
        <property type="term" value="P:activin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14142">
        <property type="entry name" value="STKc_ACVR1_ALK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23535">
        <property type="entry name" value="TFP_LU_ECD_ALK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000018">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000064">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000008">
        <property type="entry name" value="Serine/threonine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF69">
        <property type="entry name" value="ACTIVIN RECEPTOR TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 21" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="23">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="195"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="496" mass="55858" checksum="7AFB925DE880085C" modified="2019-12-11" version="1">MVQQLMKDEEPKLNSNLYMCVCEGTSCGNRDHCEGQQCFASLSINDGVQVYQKGCFQVYEQGKMTCKTPPSPDQAVECCQGNWCNGNITAQLPTSKGKSFPGAYSRFSLDYVAIFIGLSIAACLFIILLVVGIRKFKKRNQERLNPREVEYGTIDGLITTNVGDSTLADLMDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGHWQGENVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAISHRDLKSKNILVKKNGQCCIADLGLAVIHSQTNNHLDVGNNPRVGTKRYMAPEVLDETIQVNCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNSSARLTALRIKKTLTKIDNSLDKLKADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7K8</accession>
    <name>A0A5F8H7K8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Transient receptor potential cation channel subfamily C member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TRPC7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7K8"/>
    <dbReference type="Ensembl" id="ENSMODT00000066443.1">
        <property type="protein sequence ID" value="ENSMODP00000055933.1"/>
        <property type="gene ID" value="ENSMODG00000015142.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01060000248588"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015142">
        <property type="expression patterns" value="Expressed in spermatocyte and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000157">
        <property type="entry name" value="short transient receptor potential channel 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000041">
        <property type="entry name" value="Transient receptor potential cation channel subfamily C member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005463">
        <property type="entry name" value="TRPC7_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00870">
        <property type="entry name" value="trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF9">
        <property type="entry name" value="SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01648">
        <property type="entry name" value="TRPCHANNEL7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="17">
        <location>
            <begin position="189"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="839" mass="96721" checksum="9128048775EA743C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7K9</accession>
    <name>A0A5F8H7K9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A-kinase interacting protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7K9"/>
    <dbReference type="Ensembl" id="ENSMODT00000081786.1">
        <property type="protein sequence ID" value="ENSMODP00000055216.1"/>
        <property type="gene ID" value="ENSMODG00000025551.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017064"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025551">
        <property type="expression patterns" value="Expressed in testis and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901222">
        <property type="term" value="P:regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033214">
        <property type="entry name" value="AKIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14330">
        <property type="entry name" value="A-KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14330:SF2">
        <property type="entry name" value="A-KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="518" mass="57752" checksum="C356487251A10FC9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7L2</accession>
    <name>A0A5F8H7L2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Leucine-rich repeat-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DNAAF11</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts (via CS domain) with ZMYND10 (via C-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the tilB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7L2"/>
    <dbReference type="Ensembl" id="ENSMODT00000076344.1">
        <property type="protein sequence ID" value="ENSMODP00000055938.1"/>
        <property type="gene ID" value="ENSMODG00000001207.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158506"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001207">
        <property type="expression patterns" value="Expressed in spermatocyte and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060287">
        <property type="term" value="P:epithelial cilium movement involved in determination of left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061458">
        <property type="term" value="P:reproductive system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000052">
        <property type="entry name" value="Leucine rich repeat containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056496">
        <property type="entry name" value="CS_DNAAF11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23602">
        <property type="entry name" value="CS_DNAAF11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="13">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="451" mass="53063" checksum="84ACB802BC3F2864" modified="2019-12-11" version="1">MGRITEELIRKNAEHNNCEIFSLEELSLHQQEIEKLENIDKWCRDLKILYLQNNLIAKIENISRLKKLQYLNLALNNIEKIENLEGCEGLEKLDLTVNFVGELSSIKILQYNVHLKEIFLMGNPCADFEGYREFVIATLQQLQWLDGKEIERSERIQALQNYPEIRGKIKEQEKAYCLKRAKEKEEAQRKLQEDEEKEKQKENRNKPGFNGRWYTDINNTVPYSLERKENYQQLAKKEKEVNKKTQDELDKEFWEKPTLFTPESRLETHRYLEKQRRDQEKSSEKKKHQKLPRTLITADGRVLNINEPKFMDTSLIDVDVQPTYVRVMVKGKPFQIVLPAEVKPDSSCAKRSQTTGHLMITMPKVGEVILVNRKANKPMKYPERKKLQENKRSNQIEKLEVDPSKYSFPDVTNIVQEKKNTLERIPAKPQAIPCAEEDPDFEDNLEVPPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7L3</accession>
    <name>A0A5F8H7L3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7L3"/>
    <dbReference type="Ensembl" id="ENSMODT00000060215.1">
        <property type="protein sequence ID" value="ENSMODP00000055539.1"/>
        <property type="gene ID" value="ENSMODG00000044356.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161245"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000044356">
        <property type="expression patterns" value="Expressed in ovary and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cadherin" evidence="4">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="137" mass="15017" checksum="4C61D1BE066E9BEE" modified="2019-12-11" version="1">HLFYICFQFIGGDCLQLKEFPASCFVPENTSPGTRIYNFSVTLSPLASSVSSGFPLIINSSPLTRAFSINGLSGKNFEVVTTGQPPLDFETMPKSFDLQIYVKDEAGAMDLGLLTVKLKDVNEPPMFLDNLAKESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7L4</accession>
    <name>A0A5F8H7L4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inter-alpha-trypsin inhibitor heavy chain 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ITIH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7L4"/>
    <dbReference type="Ensembl" id="ENSMODT00000064953.1">
        <property type="protein sequence ID" value="ENSMODP00000055797.1"/>
        <property type="gene ID" value="ENSMODG00000010837.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161039"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010837">
        <property type="expression patterns" value="Expressed in liver and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01461">
        <property type="entry name" value="vWA_interalpha_trypsin_inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000013">
        <property type="entry name" value="inter-alpha-trypsin inhibitor heavy chain H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050934">
        <property type="entry name" value="ITIH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338:SF119">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023924786" description="Inter-alpha-trypsin inhibitor heavy chain 4" evidence="9">
        <location>
            <begin position="26"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="11">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="10">
        <location>
            <begin position="271"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="71031" checksum="E8660AD10416A3E6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7L5</accession>
    <name>A0A5F8H7L5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MORC family CW-type zinc finger protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MORC1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7L5"/>
    <dbReference type="Ensembl" id="ENSMODT00000057028.1">
        <property type="protein sequence ID" value="ENSMODP00000055544.1"/>
        <property type="gene ID" value="ENSMODG00000028546.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153998"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000028546">
        <property type="expression patterns" value="Expressed in spermatocyte and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16931">
        <property type="entry name" value="HATPase_MORC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.100:FF:000004">
        <property type="entry name" value="MORC family CW-type zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000027">
        <property type="entry name" value="MORC family CW-type zinc finger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041006">
        <property type="entry name" value="Morc_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23337:SF6">
        <property type="entry name" value="MORC FAMILY CW-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23337">
        <property type="entry name" value="ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17942">
        <property type="entry name" value="Morc6_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="7" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="15">
        <location>
            <begin position="475"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="528"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="861"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="935" mass="107670" checksum="C6DCC7CD14355EB4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7L7</accession>
    <name>A0A5F8H7L7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho-associated protein kinase 2</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Rho-associated, coiled-coil-containing protein kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Rho-associated, coiled-coil-containing protein kinase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">p164 ROCK-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="primary">ROCK2</name>
    </gene>
    <organism evidence="40 41">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="40 41" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="40" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="40" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
            <location evidence="4">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="Ensembl" id="ENSMODT00000055925.1">
        <property type="protein sequence ID" value="ENSMODP00000055943.1"/>
        <property type="gene ID" value="ENSMODG00000011938.6"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234517"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011938">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010825">
        <property type="term" value="P:positive regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006939">
        <property type="term" value="P:smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20875">
        <property type="entry name" value="C1_ROCK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11638">
        <property type="entry name" value="HR1_ROCK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01242">
        <property type="entry name" value="PH_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22250">
        <property type="entry name" value="ROCK_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000047">
        <property type="entry name" value="Rho-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000036">
        <property type="entry name" value="Rho-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000016">
        <property type="entry name" value="Rho-associated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.730:FF:000001">
        <property type="entry name" value="rho-associated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000033">
        <property type="entry name" value="Rho-associated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000072">
        <property type="entry name" value="Rho-associated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001759">
        <property type="entry name" value="Rho-associated, coiled-coil-containing protein kinase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037311">
        <property type="entry name" value="ROCK2_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015008">
        <property type="entry name" value="ROCK_Rho-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF28">
        <property type="entry name" value="RHO-ASSOCIATED PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08912">
        <property type="entry name" value="Rho_Binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103652">
        <property type="entry name" value="G protein-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51859">
        <property type="entry name" value="RHO_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 31" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20 30 32" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="23" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 31" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="41" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="35">
        <location>
            <begin position="91"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="37">
        <location>
            <begin position="356"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="39">
        <location>
            <begin position="497"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="RhoBD" evidence="38">
        <location>
            <begin position="979"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="34">
        <location>
            <begin position="1209"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="36">
        <location>
            <begin position="1319"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="1404"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="32">
        <location>
            <begin position="463"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="32">
        <location>
            <begin position="655"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="32">
        <location>
            <begin position="1056"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="1421"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="31">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00031784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00032261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS51859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1447" mass="167789" checksum="6F6E633F873DFBDA" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7L8</accession>
    <name>A0A5F8H7L8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRAPPC11</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPPC11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7L8"/>
    <dbReference type="Ensembl" id="ENSMODT00000080654.1">
        <property type="protein sequence ID" value="ENSMODP00000055549.1"/>
        <property type="gene ID" value="ENSMODG00000004292.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006550"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004292">
        <property type="expression patterns" value="Expressed in heart and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025876">
        <property type="entry name" value="TRAPPC11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12742">
        <property type="entry name" value="Gryzun-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="8">
        <location>
            <begin position="263"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 11 C-terminal" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1123" mass="127762" checksum="B48DBBF65E76B81F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7L9</accession>
    <name>A0A5F8H7L9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7L9"/>
    <dbReference type="STRING" id="13616.ENSMODP00000055807"/>
    <dbReference type="Ensembl" id="ENSMODT00000052596.1">
        <property type="protein sequence ID" value="ENSMODP00000055807.1"/>
        <property type="gene ID" value="ENSMODG00000007988.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014165"/>
    <dbReference type="InParanoid" id="A0A5F8H7L9"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007988">
        <property type="expression patterns" value="Expressed in forelimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="177" mass="20745" checksum="E0198FD7BAAC159B" modified="2019-12-11" version="1">MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKLCRCCHREFSSAFGPPDTEPHRLCIRCCTHPSHLWPWTTRTCTLTSALKKSPWTRLLSSSLQTKFQRQQKTSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7M1</accession>
    <name>A0A5F8H7M1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Basigin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">Interacts with SLC16A6; this interaction mediates targeting to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Basolateral cell membrane</location>
            <topology evidence="18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
            <location evidence="3">Photoreceptor outer segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Photoreceptor inner segment</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7M1"/>
    <dbReference type="Ensembl" id="ENSMODT00000055502.1">
        <property type="protein sequence ID" value="ENSMODP00000055955.1"/>
        <property type="gene ID" value="ENSMODG00000006517.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159142"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006517">
        <property type="expression patterns" value="Expressed in placenta and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001329">
        <property type="entry name" value="Basigin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000291">
        <property type="entry name" value="Neuroplastin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000387">
        <property type="entry name" value="Neuroplastin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF107">
        <property type="entry name" value="BASIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0465">Mannose-binding</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023863425" description="Basigin" evidence="23">
        <location>
            <begin position="22"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="38"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="222"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00066216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="386" mass="43196" checksum="51C26C92B1C77DD8" modified="2019-12-11" version="1">MGAPLLWLLAAVLLCARAASGTAGFIKSPLSKKTLVEDSVELHCEAIGRPIPEIQWWFEGNEPNETFSQLWDGARQDRIRIHATYNEHSTSTVFISNLTISDSGTYECRASNDPDRNHLWKSPKVKWVRSQANIIVIERNNIWTAIDVSSHRTLLTCKLKEAISAPIEGHRWLKGDKVLKEDKSDSLTTEYEVVSDDRSGEYQCIFLPELAGKADVQVKGPPKVYINKKSEYGNEGDSIVLTCKSSSYPSIEQWKWYKENEGEANMILVNDTEGRMSIISTPEKTELHINSADIKEDPGKYICNGTNSEGSDTAVITLKVRSRLAALWPFLGIVAEVLILVIIIFIYERRRRTDDIVEDEDGGAAPLKASSAVNEKGSNIRQRNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7M2</accession>
    <name>A0A5F8H7M2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Slit homolog 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SLIT1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000077348.1">
        <property type="protein sequence ID" value="ENSMODP00000055554.1"/>
        <property type="gene ID" value="ENSMODG00000004492.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157322"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004492">
        <property type="expression patterns" value="Expressed in spinal cord and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000080">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000045">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000053">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000054">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000062">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000063">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000013">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000389">
        <property type="entry name" value="slit homolog 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000186">
        <property type="entry name" value="Slit homolog 2 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051355">
        <property type="entry name" value="Notch/Slit_guidance"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836">
        <property type="entry name" value="SLIT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836:SF3">
        <property type="entry name" value="SLIT HOMOLOG 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="754"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="791"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="832"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="870"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="910"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="954"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="993"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1167"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1204"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1245"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="15">
        <location>
            <begin position="1254"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1169"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1191"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1208"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1230"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1249"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1271"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1347" mass="147143" checksum="26FCD53840428977" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7M3</accession>
    <name>A0A5F8H7M3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="9">MAD homolog</shortName>
            <shortName evidence="9">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SMAD4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7M3"/>
    <dbReference type="Ensembl" id="ENSMODT00000063777.1">
        <property type="protein sequence ID" value="ENSMODP00000055812.1"/>
        <property type="gene ID" value="ENSMODG00000010995.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157435"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010995">
        <property type="expression patterns" value="Expressed in hindlimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10492">
        <property type="entry name" value="MH1_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF45">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="MH1" evidence="13">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="14">
        <location>
            <begin position="242"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="380" mass="42504" checksum="BA853A1D1F7B25DB" modified="2019-12-11" version="1">MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSSAPSSMLVKDEYVPDFEGQPSLSTEGHSIQTIQHPPSNRASSETYPAMLAPSESNTTSTTNFPNIPVASTRPVHNEIAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRLYICVCIYIYICILMCMYFCMHISIYLCLVLSSYTVCHSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7M4</accession>
    <name>A0A5F8H7M4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SCY1-like protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Coated vesicle-associated kinase of 104 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SCYL2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system. A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed. By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7M4"/>
    <dbReference type="FunCoup" id="A0A5F8H7M4">
        <property type="interactions" value="2762"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055953"/>
    <dbReference type="Ensembl" id="ENSMODT00000066218.1">
        <property type="protein sequence ID" value="ENSMODP00000055953.1"/>
        <property type="gene ID" value="ENSMODG00000005075.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00880000138031"/>
    <dbReference type="InParanoid" id="A0A5F8H7M4"/>
    <dbReference type="OMA" id="MAHKCIP"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005075">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021860">
        <property type="term" value="P:pyramidal neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000179">
        <property type="entry name" value="SCY1 like pseudokinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000352">
        <property type="entry name" value="SCY1-like pseudokinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000189">
        <property type="entry name" value="SCY1-like pseudokinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="32"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="905"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="931" mass="103517" checksum="47B2D7B4D28CBBEA" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7M5</accession>
    <name>A0A5F8H7M5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP binding cassette subfamily A member 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ABCA13</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000060258.1">
        <property type="protein sequence ID" value="ENSMODP00000055960.1"/>
        <property type="gene ID" value="ENSMODG00000009406.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161703"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032376">
        <property type="term" value="P:positive regulation of cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000689">
        <property type="entry name" value="ATP binding cassette subfamily A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF113">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3248"/>
            <end position="3271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3292"/>
            <end position="3314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3326"/>
            <end position="3350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3357"/>
            <end position="3377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3383"/>
            <end position="3409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3430"/>
            <end position="3452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="4093"/>
            <end position="4113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="4143"/>
            <end position="4164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="4171"/>
            <end position="4191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="4203"/>
            <end position="4230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="4288"/>
            <end position="4310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="3522"/>
            <end position="3755"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="4353"/>
            <end position="4591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="4693" mass="535873" checksum="281E665E71A76C58" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7N0</accession>
    <name>A0A5F8H7N0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spermatosis associated 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SPATA6</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPATA6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7N0"/>
    <dbReference type="Ensembl" id="ENSMODT00000067994.1">
        <property type="protein sequence ID" value="ENSMODP00000055963.1"/>
        <property type="gene ID" value="ENSMODG00000001370.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063821"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001370">
        <property type="expression patterns" value="Expressed in testis and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120212">
        <property type="term" value="C:sperm head-tail coupling apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032027">
        <property type="term" value="F:myosin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042769">
        <property type="entry name" value="SPATA6_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032732">
        <property type="entry name" value="SPATA6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16435:SF3">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16435">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 6 SPATA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14909">
        <property type="entry name" value="SPATA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 6 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="447" mass="51660" checksum="78C4479CBADBA5F2" modified="2019-12-11" version="1">MPKMKALQCALALEIRSITCPRLQLKDKEDVYLSVCVFGQYKKTECVPPIFPLVFNARMVFEKVFPDAIDPGDVVAQLEYDTAVFELIQLVLPVGETLSTYEENTRDFMFPGPKQMSGHHDSNRQVTMQRISGIRGLAPRLEFSTTSVITECLISSRKCRGVQDKLLCHANPAERNHGRMQMRGAARPSKKKSRSPERHKYCVNPRNYEQPTISSKCHSPSPYTKRRMCELSEDTRRRLAHLNLGPYEFKKDTDKPPFVIRHADTPNPKLEALLGYSGRESSREGWCKMHNDHTHLGSYRPKDYKITKPSHGRDREDSLDRCEEYLASRQSRPHNTDRNLLVHSAPSTMQKRSPSPVLNHSSLRERYHSDWCSPSNSDEIHERVKNVLKSHGTHQRCLYDERDQEKDEELDLKRSFAYKDSLCDSDPEYRKSRRPEEGRGLCFHDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7N1</accession>
    <name>A0A5F8H7N1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Myc box-dependent-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Amphiphysin II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Amphiphysin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Bridging integrator 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BIN1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <location evidence="16">Sarcolemma</location>
            <location evidence="16">T-tubule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7N1"/>
    <dbReference type="Ensembl" id="ENSMODT00000076270.1">
        <property type="protein sequence ID" value="ENSMODP00000055822.1"/>
        <property type="gene ID" value="ENSMODG00000018719.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182882"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018719">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12139">
        <property type="entry name" value="SH3_Bin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000013">
        <property type="entry name" value="Amphiphysin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000029">
        <property type="entry name" value="myc box-dependent-interacting protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003005">
        <property type="entry name" value="Amphiphysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035471">
        <property type="entry name" value="Amphiphysin-2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003023">
        <property type="entry name" value="Amphiphysin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514:SF4">
        <property type="entry name" value="MYC BOX-DEPENDENT-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01253">
        <property type="entry name" value="AMPHIPHYSIN2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 21" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="25">
        <location>
            <begin position="29"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="24">
        <location>
            <begin position="455"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="278"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00080400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="528" mass="58754" checksum="C07E4F0A94CA0A79" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7N5</accession>
    <name>A0A5F8H7N5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Paired related homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PRRX1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7N5"/>
    <dbReference type="Ensembl" id="ENSMODT00000053242.1">
        <property type="protein sequence ID" value="ENSMODP00000055827.1"/>
        <property type="gene ID" value="ENSMODG00000003582.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159466"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003582">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000066">
        <property type="entry name" value="Paired mesoderm homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043378">
        <property type="entry name" value="PRRX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46385:SF1">
        <property type="entry name" value="PAIRED MESODERM HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46385">
        <property type="entry name" value="PAIRED MESODERM HOMEOBOX PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="200" mass="22543" checksum="50AC3A45DB3319EE" modified="2019-12-11" version="1">MTSSYGHVLERQPALGGRLDSPGNLDNLQAKKNFSVSHLLDLEEAGDMVAAQADESVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7N8</accession>
    <name>A0A5F8H7N8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CAPZB</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7N8"/>
    <dbReference type="FunCoup" id="A0A5F8H7N8">
        <property type="interactions" value="1503"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055973"/>
    <dbReference type="Ensembl" id="ENSMODT00000062219.1">
        <property type="protein sequence ID" value="ENSMODP00000055973.1"/>
        <property type="gene ID" value="ENSMODG00000015888.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017957"/>
    <dbReference type="InParanoid" id="A0A5F8H7N8"/>
    <dbReference type="OMA" id="WSNKYYP"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015888">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098686">
        <property type="term" value="C:hippocampal mossy fiber to CA3 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120212">
        <property type="term" value="C:sperm head-tail coupling apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051490">
        <property type="term" value="P:negative regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022604">
        <property type="term" value="P:regulation of cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.30">
        <property type="entry name" value="Capz alpha-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF2">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="308" mass="34725" checksum="492E1784DBE4D8B1" modified="2019-12-11" version="1">MFGGIFMLAITIIIGLLLFVFILILLLSFLSQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNRYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVCDSSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSIDAIPDNQKFKQLQRELSQVLTQRQISIQPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H801</accession>
    <name>A0A5F8H801_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenylate kinase 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H801"/>
    <dbReference type="Ensembl" id="ENSMODT00000067121.1">
        <property type="protein sequence ID" value="ENSMODP00000056090.1"/>
        <property type="gene ID" value="ENSMODG00000019421.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015930"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019421">
        <property type="expression patterns" value="Expressed in blood and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="47" mass="5019" checksum="FE7E0197BD12CE3E" modified="2019-12-11" version="1">MRLPNILLTGTPGVGKTTLGKELASRTGLKYVNVGDLAQEGDTVRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H802</accession>
    <name>A0A5F8H802_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM domain only protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LMO3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H802"/>
    <dbReference type="FunCoup" id="A0A5F8H802">
        <property type="interactions" value="1220"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000055937"/>
    <dbReference type="Ensembl" id="ENSMODT00000070084.1">
        <property type="protein sequence ID" value="ENSMODP00000055937.1"/>
        <property type="gene ID" value="ENSMODG00000042620.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153908"/>
    <dbReference type="InParanoid" id="A0A5F8H802"/>
    <dbReference type="OMA" id="DKMTMDG"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000042620">
        <property type="expression patterns" value="Expressed in spinal cord and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000324">
        <property type="term" value="P:positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035360">
        <property type="term" value="P:positive regulation of peroxisome proliferator activated receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09388">
        <property type="entry name" value="LIM1_LMO1_LMO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09389">
        <property type="entry name" value="LIM2_LMO1_LMO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000015">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000016">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF7">
        <property type="entry name" value="LIM DOMAIN ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="163" mass="18581" checksum="62FD3EF4C44965B9" modified="2019-12-11" version="1">MLMEEGREAPSLNISSIQMLSVQPDTKPKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGVTGNCAACSKLIPAFEMVMRAKDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQTDYEEGLMKEGYAPQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>F6SGK8</accession>
    <name>F6SGK8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Dynein axonemal heavy chain 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">DNAH9</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000000287.4">
        <property type="protein sequence ID" value="ENSMODP00000000283.4"/>
        <property type="gene ID" value="ENSMODG00000000233.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159717"/>
    <dbReference type="HOGENOM" id="CLU_000038_4_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000233">
        <property type="expression patterns" value="Expressed in ovary and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000219">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000682">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000007">
        <property type="entry name" value="Dynein axonemal heavy chain 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000002">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000411">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000001">
        <property type="entry name" value="Dynein, axonemal, heavy chain 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF4">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="16">
        <location>
            <begin position="205"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="17">
        <location>
            <begin position="1282"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="18">
        <location>
            <begin position="1822"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="22">
        <location>
            <begin position="2306"/>
            <end position="2423"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="23">
        <location>
            <begin position="2641"/>
            <end position="2738"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="20">
        <location>
            <begin position="2785"/>
            <end position="3044"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="19">
        <location>
            <begin position="3058"/>
            <end position="3400"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="21">
        <location>
            <begin position="3427"/>
            <end position="3644"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="15">
        <location>
            <begin position="3888"/>
            <end position="4007"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="24">
        <location>
            <begin position="4039"/>
            <end position="4175"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="25">
        <location>
            <begin position="4182"/>
            <end position="4476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3286"/>
            <end position="3327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000000283.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="4478" mass="514901" checksum="61E37517924146D7" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F6TJR0</accession>
    <name>F6TJR0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glia maturation factor beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GMFB</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6TJR0"/>
    <dbReference type="Ensembl" id="ENSMODT00000014847.4">
        <property type="protein sequence ID" value="ENSMODP00000014579.4"/>
        <property type="gene ID" value="ENSMODG00000011639.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008920"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011639">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6TJR0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000024">
        <property type="entry name" value="Glia maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF3">
        <property type="entry name" value="GLIA MATURATION FACTOR BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0339">Growth factor</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="7">
        <location>
            <begin position="48"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000014579.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="221" mass="25553" checksum="33EFFA85851B9B76" modified="2019-12-11" version="3">MSHSLIGWGRLAQPARGRKEGGGDSILEKALGKTPPGWWPAGRKMSESLVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVVLDEEHEGISPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKLPFVPCFAFRLTTIIFPPINLYRCHFCHYLSFFSLPYALKQHLWNYRRDLLIKVGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F6TK46</accession>
    <name>F6TK46_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tropomyosin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TPM3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007482023.1">
        <property type="nucleotide sequence ID" value="XM_007481961.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6TK46"/>
    <dbReference type="Ensembl" id="ENSMODT00000021907.3">
        <property type="protein sequence ID" value="ENSMODP00000021531.3"/>
        <property type="gene ID" value="ENSMODG00000017253.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100015402"/>
    <dbReference type="CTD" id="7170"/>
    <dbReference type="eggNOG" id="KOG1003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234542"/>
    <dbReference type="HOGENOM" id="CLU_055027_0_0_1"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017253">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000004">
        <property type="entry name" value="tropomyosin alpha-1 chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000021531.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="285" mass="33046" checksum="91C9B1736F3A4F8B" modified="2019-12-11" version="2">MMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEDRSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F6VPR1</accession>
    <name>F6VPR1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calmodulin-lysine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CAMKMT</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the trimethylation of 'Lys-116' in calmodulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21556"/>
            <dbReference type="Rhea" id="RHEA-COMP:11360"/>
            <dbReference type="Rhea" id="RHEA-COMP:11361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.60"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with HSP90, probably as a client.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.60" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="F6VPR1"/>
    <dbReference type="Ensembl" id="ENSMODT00000000915.3">
        <property type="protein sequence ID" value="ENSMODP00000000897.3"/>
        <property type="gene ID" value="ENSMODG00000000747.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002168"/>
    <dbReference type="HOGENOM" id="CLU_057006_3_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000747">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018025">
        <property type="term" value="F:calmodulin-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000140">
        <property type="entry name" value="Calmodulin-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025800">
        <property type="entry name" value="CaM-Lys-N-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13539">
        <property type="entry name" value="CALMODULIN-LYSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13539:SF3">
        <property type="entry name" value="CALMODULIN-LYSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000000897.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="230" mass="26076" checksum="57C6F43C65CD9250" modified="2019-12-11" version="2">MSKHRTQENHQKVSRASRPILYAILCTFTCGKCIWPSEEVLAYYCLKHNQMFRDLAVCELGGGMTCLAGLMVAISADVKEVLLTDGNEKAIKNVNDIIARNQKEGVFKTQAVSSCVLRWDNETDVSQLEGHFDIVMCADCLFLDQYRASLVDAIKRLLQPSGKAMVFAPLRGTTLNQFCNLAEKAGFSLQRHENYDEHISNFHSKLKDEEWDTYEENLHYPLLLVLSKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>F6VPX9</accession>
    <name>F6VPX9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kalirin RhoGEF kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000038406.3">
        <property type="protein sequence ID" value="ENSMODP00000036810.2"/>
        <property type="gene ID" value="ENSMODG00000018350.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155248"/>
    <dbReference type="HOGENOM" id="CLU_000373_2_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018350">
        <property type="expression patterns" value="Expressed in cerebellum and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13240">
        <property type="entry name" value="PH1_Kalirin_Trio_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000034">
        <property type="entry name" value="kalirin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000003">
        <property type="entry name" value="kalirin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000024">
        <property type="entry name" value="Kalirin RhoGEF kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000023">
        <property type="entry name" value="Kalirin RhoGEF kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000032">
        <property type="entry name" value="Kalirin RhoGEF kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000040">
        <property type="entry name" value="Kalirin RhoGEF kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000015">
        <property type="entry name" value="triple functional domain protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047054">
        <property type="entry name" value="Kalirin_TRIO_PH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058918">
        <property type="entry name" value="KALRN/TRIO-like_spectrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23323">
        <property type="entry name" value="Spectrin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="10">
        <location>
            <begin position="46"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="1270"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1457"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1583"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="917"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1616"/>
            <end position="1628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000036810.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1717" mass="197571" checksum="E9C10F5D0D710140" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F6WT70</accession>
    <name>F6WT70_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spermidine/spermine N1-acetyltransferase family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SAT2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6WT70"/>
    <dbReference type="Ensembl" id="ENSMODT00000009115.3">
        <property type="protein sequence ID" value="ENSMODP00000008939.3"/>
        <property type="gene ID" value="ENSMODG00000007208.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183121"/>
    <dbReference type="HOGENOM" id="CLU_013985_41_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007208">
        <property type="expression patterns" value="Expressed in heart and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6WT70">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006595">
        <property type="term" value="P:polyamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000011">
        <property type="entry name" value="Diamine acetyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF51">
        <property type="entry name" value="THIALYSINE N-EPSILON-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000008939.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="181" mass="20916" checksum="A23747E4E45141DE" modified="2019-12-11" version="2">EVEEHRIPLILDLQLHREDRGGHQSYSPLLYTEELAEFEKLLDQVKISEGALKTDGFGENPFYHCLVAEIPPESREPQGSTVVGYGLYYFTYSTWTGRNVYLEDIYVMPKYRGQGIGSKIIKKVAEVALEKGCSQFRLAVLDWNESAMDFYKARGAKDLTVAEGWRFFRFDNEAMRELVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>F6X4U1</accession>
    <name>F6X4U1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Betaine--homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BHMT</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the regulation of homocysteine metabolism.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6X4U1"/>
    <dbReference type="Ensembl" id="ENSMODT00000025059.3">
        <property type="protein sequence ID" value="ENSMODP00000024623.3"/>
        <property type="gene ID" value="ENSMODG00000025328.2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003122"/>
    <dbReference type="HOGENOM" id="CLU_047457_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025328">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6X4U1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008172">
        <property type="term" value="F:S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000003">
        <property type="entry name" value="Betaine--homocysteine S-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051524">
        <property type="entry name" value="BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120">
        <property type="entry name" value="BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120:SF3">
        <property type="entry name" value="S-METHYLMETHIONINE--HOMOCYSTEINE S-METHYLTRANSFERASE BHMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="9">
        <location>
            <begin position="11"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000024623.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="399" mass="44057" checksum="BF0D62CAD631E248" modified="2019-12-11" version="2">MAPVGGKRAKKGILERLHSGEVVIGDGSFLFTLEKRGYVKAGLWTPEATVEHPEAVRQLHTEYLRAGSNVMQTFTFFAGKDNLESKWKEVNEAACDLAREVAEKGDALVAGGISQTSLYKSHGSEPEIKENFQLQLEVFTRKNVDFLIAEYFEYCEEAVWAVEVLKGSGKPVAATMCIGPEGDMNNLTPGECAVRLVKAGASIVGVNCRFGPEISLATVKLMKEGLEASGLKAYLMVQSLGFHTPDCGKGGFVDLPQYPFGLEPRVATRWDIQKYAREAYKLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPDASEKHGSWGSGLNMHTKPWVRARARREYWESLPLASGRPYCPSMSKPDAWGVTKGTAELMQQKEATTDQQLKELFEKQKFKSSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>F6XVY7</accession>
    <name>F6XVY7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">EPHA4</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_001365863.1">
        <property type="nucleotide sequence ID" value="XM_001365826.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6XVY7"/>
    <dbReference type="FunCoup" id="F6XVY7">
        <property type="interactions" value="660"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000026482"/>
    <dbReference type="Ensembl" id="ENSMODT00000026955.4">
        <property type="protein sequence ID" value="ENSMODP00000026482.2"/>
        <property type="gene ID" value="ENSMODG00000021189.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100016017"/>
    <dbReference type="KEGG" id="mdo:100016017"/>
    <dbReference type="CTD" id="2043"/>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156948"/>
    <dbReference type="HOGENOM" id="CLU_000288_141_1_1"/>
    <dbReference type="InParanoid" id="F6XVY7"/>
    <dbReference type="OMA" id="YDEHNGE"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021189">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097161">
        <property type="term" value="F:DH domain binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005003">
        <property type="term" value="F:ephrin receptor activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042731">
        <property type="term" value="F:PH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140694">
        <property type="term" value="P:membraneless organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900038">
        <property type="term" value="P:negative regulation of cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010719">
        <property type="term" value="P:negative regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903051">
        <property type="term" value="P:negative regulation of proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045785">
        <property type="term" value="P:positive regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10482">
        <property type="entry name" value="EphR_LBD_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05066">
        <property type="entry name" value="PTKc_EphR_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09545">
        <property type="entry name" value="SAM_EPH-A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000041">
        <property type="entry name" value="ephrin type-A receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000019">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000045">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1770:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034270">
        <property type="entry name" value="EphA4_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030602">
        <property type="entry name" value="EphA4_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001426">
        <property type="entry name" value="Tyr_kinase_rcpt_V_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF18">
        <property type="entry name" value="EPHRIN TYPE-A RECEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25599">
        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00790">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00791">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14 24 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="18 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11 24 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 28" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="19" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003345597" description="receptor protein-tyrosine kinase" evidence="28">
        <location>
            <begin position="20"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="32">
        <location>
            <begin position="30"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="31">
        <location>
            <begin position="328"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="31">
        <location>
            <begin position="440"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="621"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="30">
        <location>
            <begin position="911"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="23">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="627"/>
            <end position="635"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 26">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="73"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000026482.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="986" mass="109934" checksum="ED2A44024E79AB22" modified="2011-07-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>F7BPR7</accession>
    <name>F7BPR7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Calsyntenin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">CLSTN2</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calsyntenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7BPR7"/>
    <dbReference type="FunCoup" id="F7BPR7">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000023213"/>
    <dbReference type="Ensembl" id="ENSMODT00000023626.4">
        <property type="protein sequence ID" value="ENSMODP00000023213.3"/>
        <property type="gene ID" value="ENSMODG00000018610.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183086"/>
    <dbReference type="HOGENOM" id="CLU_008904_0_0_1"/>
    <dbReference type="InParanoid" id="F7BPR7"/>
    <dbReference type="OMA" id="HMVIQPQ"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018610">
        <property type="expression patterns" value="Expressed in spermatid and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008306">
        <property type="term" value="P:associative learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904862">
        <property type="term" value="P:inhibitory synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000025">
        <property type="entry name" value="Calsyntenin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000029">
        <property type="entry name" value="Calsyntenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000062">
        <property type="entry name" value="Calsyntenin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045588">
        <property type="entry name" value="CLSTN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139">
        <property type="entry name" value="CALSYNTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139:SF3">
        <property type="entry name" value="CALSYNTENIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19699">
        <property type="entry name" value="CLSTN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 22" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="740"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="25">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="25">
        <location>
            <begin position="72"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="797"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="811"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00059096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00069677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000023213.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="872" mass="98836" checksum="190944223FD278F9" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>F7BPS2</accession>
    <name>F7BPS2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7BPS2"/>
    <dbReference type="Ensembl" id="ENSMODT00000023623.4">
        <property type="protein sequence ID" value="ENSMODP00000023210.4"/>
        <property type="gene ID" value="ENSMODG00000018608.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRKJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155081"/>
    <dbReference type="HOGENOM" id="CLU_003751_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018608">
        <property type="expression patterns" value="Expressed in spinal cord and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15251">
        <property type="entry name" value="7tmB2_BAI_Adhesion_VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000016">
        <property type="entry name" value="Adhesion G protein-coupled receptor B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008077">
        <property type="entry name" value="GPCR_2_brain_angio_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF40">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01694">
        <property type="entry name" value="BAIPRECURSOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000023210.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="518" mass="57596" checksum="9C3BAF66B8077476" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>F7BPY1</accession>
    <name>F7BPY1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protocadherin-19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PCDH19</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7BPY1"/>
    <dbReference type="FunCoup" id="F7BPY1">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000011232"/>
    <dbReference type="Ensembl" id="ENSMODT00000011450.4">
        <property type="protein sequence ID" value="ENSMODP00000011232.4"/>
        <property type="gene ID" value="ENSMODG00000009008.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159162"/>
    <dbReference type="HOGENOM" id="CLU_006480_1_1_1"/>
    <dbReference type="InParanoid" id="F7BPY1"/>
    <dbReference type="OMA" id="RCWMPRG"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009008">
        <property type="expression patterns" value="Expressed in spinal cord and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000360">
        <property type="entry name" value="Protocadherin 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000088">
        <property type="entry name" value="protocadherin-19 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000099">
        <property type="entry name" value="protocadherin-19 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF40">
        <property type="entry name" value="PROTOCADHERIN-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023935105" description="Protocadherin-19" evidence="17">
        <location>
            <begin position="21"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="115"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="224"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="335"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="439"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="554"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="709"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1067"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="876"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1077"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1100"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011232.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1116" mass="121870" checksum="C4001273CBC8148D" modified="2019-12-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F7C227</accession>
    <name>F7C227_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription and mRNA export factor ENY2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Enhancer of yellow 2 transcription factor homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ENY2</name>
        <name evidence="13" type="synonym">PKHD1L1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
            <location evidence="1 12">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ENY2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7C227"/>
    <dbReference type="Ensembl" id="ENSMODT00000006160.3">
        <property type="protein sequence ID" value="ENSMODP00000006032.3"/>
        <property type="gene ID" value="ENSMODG00000004891.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157594"/>
    <dbReference type="HOGENOM" id="CLU_134052_1_1_1"/>
    <dbReference type="OMA" id="CHNTIKE"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004891">
        <property type="expression patterns" value="Expressed in spermatid and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7C227">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.140:FF:000001">
        <property type="entry name" value="Transcription and mRNA export factor ENY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03046">
        <property type="entry name" value="ENY2_Sus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12514">
        <property type="entry name" value="ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0010">Activator</keyword>
    <keyword evidence="4 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 12" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000006032.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="127" mass="14559" checksum="6E5BBFC4EE29DD94" modified="2019-12-11" version="2">MMSTYNISKMNKDAQMRATINQKLIETGERERLKELLRAKLIECGWKDQLKAHCKDVIKEKGLEHVTVDDLVAEITPKGRGSWGTDRLGRKRNEVDVKTKTSTLVPDSVKKELLQRIRTFLAQHASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F7D563</accession>
    <name>F7D563_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450 2J2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100031975</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7D563"/>
    <dbReference type="Ensembl" id="ENSMODT00000038760.3">
        <property type="protein sequence ID" value="ENSMODP00000037161.2"/>
        <property type="gene ID" value="ENSMODG00000003225.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182879"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003225">
        <property type="expression patterns" value="Expressed in liver and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7D563">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008071">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF177">
        <property type="entry name" value="CYTOCHROME P450 2J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01688">
        <property type="entry name" value="EP450ICYP2J"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000037161.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="504" mass="57899" checksum="355A5379D60C596D" modified="2019-12-11" version="2">MQLPLGNVLPSLQTLLLFSAILLILASYVQRRRRRQQLKYPPGPLRLPIFGNVFQIDTTKAHVSVQEFVRKFGNIFSMELFGVPMMTVTGLPLIKEVLINQGQVFVDRPQFPLQTYTFKSVGLLMSNGQEWKDQRRFTLMTLRNFGLGKKTLELRIQEEATYLIEAIREEKGQPFDPHFQINNAVSNIICSVTFGNRFEYHDSQFRELLKSLDQVSVLQASWECQFFNIIPWIMKFLPGAHKKLFREFKKLESFVVHVIKQHKEDQNSEEARDFIDAYLKELSKGNNSSSFNEDNLVSCTLDLFFAGTETTSTTLRWALLYMALYPEIQGKIQAEIDRVIGHSRQPTMADRENMPYTYAAIHEVQRMGNIIPLNAARVATVDTTLAGYHVPKGTWLLTNLTALHRDPKEWATPETFNPEHFLENGEFKKRESFLPFSAGKRVCLGEQLARAELFIFFTCLLQRFTFQAPPDTQLSLDFRAGLTISPAPYKICALPRETQPKVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>F7D572</accession>
    <name>F7D572_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fatty acid binding protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FABP6</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7D572"/>
    <dbReference type="Ensembl" id="ENSMODT00000010151.3">
        <property type="protein sequence ID" value="ENSMODP00000009959.2"/>
        <property type="gene ID" value="ENSMODG00000008000.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157139"/>
    <dbReference type="HOGENOM" id="CLU_113772_4_0_1"/>
    <dbReference type="OMA" id="KCIGIPS"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008000">
        <property type="expression patterns" value="Expressed in forelimb bud and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000006">
        <property type="entry name" value="Fatty acid-binding protein, liver"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14651">
        <property type="entry name" value="Lipocalin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000009959.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="127" mass="14261" checksum="9546B077677CFE71" modified="2013-01-09" version="2">MTSGKYEVESEKNYEAFLNQLGISKDTIEKYRNFKTLTEVVQDGNNFTWINTYPGGQIMTNKFTIGKECEMETMGGKKFKATVQMEGNKIVATFPNYQQTSEIVGGKLVEISTSGGVTYERVSKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>F7D582</accession>
    <name>F7D582_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leukotriene A-4 hydrolase</fullName>
            <ecNumber evidence="4">3.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leukotriene A(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LTA4H</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; leukotriene B4 biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.6" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="F7D582"/>
    <dbReference type="MEROPS" id="M01.004"/>
    <dbReference type="Ensembl" id="ENSMODT00000010149.3">
        <property type="protein sequence ID" value="ENSMODP00000009957.3"/>
        <property type="gene ID" value="ENSMODG00000007997.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156375"/>
    <dbReference type="HOGENOM" id="CLU_014505_1_2_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007997">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004463">
        <property type="term" value="F:leukotriene-A4 hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019370">
        <property type="term" value="P:leukotriene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000003">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0434">Leukotriene biosynthesis</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023867887" description="Leukotriene A-4 hydrolase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="18">
        <location>
            <begin position="17"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="17">
        <location>
            <begin position="197"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000009957.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="496" mass="55948" checksum="6B60070223698E26" modified="2019-12-11" version="3">MFLILLSSLKILILLQVLDTKDLKIEKVVINGQEVQFILGERQSFKGSPLEITLPVTLSKKQEVVVEISYETSPQSSALQWLTPEQTSGKKHPYLFSQCQAIHCRAILPCQDTPSVKLTYSAEVSVPNELVALMSAVRDGEAPDPADSSRKIYKFTQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVEKSAFEFSETERMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGQLFGEKFRHFHALGGWGELQNSIKTFGDTHAFTKLVVSLKDVDPDEVYSSVPYEKGFALLFYLEQLLGGPEVFLAFLKAYIKEFSYKSITTDDWKTFLYSYFKDKTDVLNEVDWNAWFFSPGLPPVKPKYDMTLTKTCIDLSQRWITAKEDDLSTFCSTDIKDMSSHQLVEFLALMLLAMAAPLYPVQVGGRHPSGARNGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>F7DVW5</accession>
    <name>F7DVW5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Progestin and adipoQ receptor family member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PAQR5</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056664911.1">
        <property type="nucleotide sequence ID" value="XM_056808933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7DVW5"/>
    <dbReference type="Ensembl" id="ENSMODT00000011777.3">
        <property type="protein sequence ID" value="ENSMODP00000011557.2"/>
        <property type="gene ID" value="ENSMODG00000009253.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100026328"/>
    <dbReference type="CTD" id="54852"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158844"/>
    <dbReference type="HOGENOM" id="CLU_052356_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009253">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF38">
        <property type="entry name" value="MEMBRANE PROGESTIN RECEPTOR GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011557.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="300" mass="34472" checksum="F3164C448EB21E3E" modified="2019-12-11" version="2">MLSLKLPKLFNIDQVPPVFHERGIICGYRHPQSSAIACVLSLFQMTNETLNIWTHLLPSWYFMWRFMATLYMVDFWNDSYSWPLLIYLSTSFIYPFASSCAHTFSSMSKNARHICYFLDYGAVNLFSLGSAIAYSAYTFPDMLVRTTFHHYFVSLAVLNTILSIGLSCYSRFLELQKPKLCKTLRILAFAYPYAWDTVPIIYRLFLSSEESSGEAANPYHQKHTVIAILACFLYAAHLPERLAPGRFDYIGHSHQLFHVCVILATHLQMEAIFLDMTLRKEWLLATSIPPSFSQTAGAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>F7E7Y3</accession>
    <name>F7E7Y3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-type lectin domain containing 16A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CLEC16A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLEC16A/gop-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7E7Y3"/>
    <dbReference type="Ensembl" id="ENSMODT00000006495.4">
        <property type="protein sequence ID" value="ENSMODP00000006363.3"/>
        <property type="gene ID" value="ENSMODG00000005166.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013826"/>
    <dbReference type="HOGENOM" id="CLU_007413_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005166">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045820">
        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="4">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="245"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="888"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="890"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="916"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000006363.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="957" mass="108318" checksum="2D9F624138E59E57" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4F0</accession>
    <name>A0A5F8G4F0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">START domain-containing protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PCTP-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">StAR-related lipid transfer protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">STARD10</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4F0"/>
    <dbReference type="FunCoup" id="A0A5F8G4F0">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042353"/>
    <dbReference type="Ensembl" id="ENSMODT00000055760.1">
        <property type="protein sequence ID" value="ENSMODP00000042353.1"/>
        <property type="gene ID" value="ENSMODG00000007754.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047611"/>
    <dbReference type="InParanoid" id="A0A5F8G4F0"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007754">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08871">
        <property type="entry name" value="START_STARD10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000008">
        <property type="entry name" value="START domain containing 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041951">
        <property type="entry name" value="STARD10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF7">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="18">
        <location>
            <begin position="73"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="290" mass="32900" checksum="3EAEDCC9A8901CD4" modified="2019-12-11" version="1">MLSRLWPGMQLPMVVLHFVFVGLPFPDPPLAWFLGSLLCLVGPASPLCIWPLGAPQTWTLTFVHLSVHPQCRMECRDVPAETVYDVLHDIEYRKKWDSNVIETFDIARLTVNADVGYYSWRCPKPLKNRDVITLRSWLPMGADYIIMNYSVKHPKYPPRKDLVRAVSIQTGYLIQSTGPKNSVITYLAQVDPKGSLPKWVVNKSSQFLAPKAMKKMYKACMKYPEWKQKHQPHFKPWLHPEQSPLPSVALSELSVQHADSLENIDESTVAESRDERGAGGEGSDDDSSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4F3</accession>
    <name>A0A5F8G4F3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Syntrophin gamma 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SNTG1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntrophin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4F3"/>
    <dbReference type="Ensembl" id="ENSMODT00000080211.1">
        <property type="protein sequence ID" value="ENSMODP00000042320.1"/>
        <property type="gene ID" value="ENSMODG00000009907.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182863"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009907">
        <property type="expression patterns" value="Expressed in spermatid and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000404">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000448">
        <property type="entry name" value="Syntrophin gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF2">
        <property type="entry name" value="GAMMA-1-SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="63"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="264"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="500" mass="56223" checksum="73A60F813816C823" modified="2019-12-11" version="1">MDFRTSCEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGGGAEHNIPVVISKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLLLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPTNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYLPGSDLCRQNAFQVIAVDGVCSGIIQCLSAEDCIDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWTEEREQDSLQDRKYTPKFLALRGSSLYKFLAPPVTTWDWTRAEKTFSVYEIMFKIFKDSDLLDRRKHCFGVQSETGEDLYFSVELECDLAQWEKAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSMGFVCFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLYLGNQASASASTSASSAATGKVKYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4F4</accession>
    <name>A0A5F8G4F4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 2 open reading frame 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C2orf42</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4F4"/>
    <dbReference type="Ensembl" id="ENSMODT00000082759.1">
        <property type="protein sequence ID" value="ENSMODP00000042337.1"/>
        <property type="gene ID" value="ENSMODG00000011505.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011031"/>
    <dbReference type="OrthoDB" id="6506929at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011505">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026049">
        <property type="entry name" value="C2orf42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029269">
        <property type="entry name" value="Zf-tcix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13518:SF1">
        <property type="entry name" value="C2ORF42 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13518">
        <property type="entry name" value="PUTATIVE TREBLE-CLEF ZINC-FINGER C2ORF42 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14952">
        <property type="entry name" value="zf-tcix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative treble-clef zinc-finger" evidence="1">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="576" mass="64544" checksum="E499F1EEA2283030" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4F6</accession>
    <name>A0A5F8G4F6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="4">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aldehyde dehydrogenase family 4 member A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ALDH4A1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4F6"/>
    <dbReference type="FunCoup" id="A0A5F8G4F6">
        <property type="interactions" value="1354"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042358"/>
    <dbReference type="Ensembl" id="ENSMODT00000087729.1">
        <property type="protein sequence ID" value="ENSMODP00000042358.1"/>
        <property type="gene ID" value="ENSMODG00000020887.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00560000077335"/>
    <dbReference type="InParanoid" id="A0A5F8G4F6"/>
    <dbReference type="OMA" id="NVYYPYM"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020887">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14516">
        <property type="entry name" value="1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14516:SF3">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="18">
        <location>
            <begin position="80"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="777" mass="86398" checksum="67357AA91A78C0D0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4F9</accession>
    <name>A0A5F8G4F9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-cell surface glycoprotein CD3 zeta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">T-cell receptor T3 zeta chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CD247</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD3Z/FCER1G family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4F9"/>
    <dbReference type="Ensembl" id="ENSMODT00000067003.1">
        <property type="protein sequence ID" value="ENSMODP00000042325.1"/>
        <property type="gene ID" value="ENSMODG00000002586.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018208"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002586">
        <property type="expression patterns" value="Expressed in blood and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021663">
        <property type="entry name" value="CD3_zeta/IgE_Fc_rcpt_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003110">
        <property type="entry name" value="Phos_immunorcpt_sig_ITAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024128">
        <property type="entry name" value="T-cell_CD3_zeta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10035">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10035:SF2">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11628">
        <property type="entry name" value="TCR_zetazeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00077">
        <property type="entry name" value="ITAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51055">
        <property type="entry name" value="ITAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023897209" description="T-cell surface glycoprotein CD3 zeta chain" evidence="18">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="155" mass="17619" checksum="BA0005C509C83D85" modified="2019-12-11" version="1">MKWKEIVIAAILQALVPITEAQDFGLADPRLCYLLDGILFIYGVIITALFLRAKFSKTARVSAYQRDQNQVYNELSMGRREEYDILDKRRGGHDPEIGGKQSLQKDKMAEAYSEIGMKGEKQRRRGKGNDVLYQGLSPATKDTYDALHMQPLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4G1</accession>
    <name>A0A5F8G4G1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4G1"/>
    <dbReference type="Ensembl" id="ENSMODT00000068894.1">
        <property type="protein sequence ID" value="ENSMODP00000042324.1"/>
        <property type="gene ID" value="ENSMODG00000048797.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286947"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000268">
        <property type="entry name" value="Putative olfactory receptor 2I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="286" mass="32363" checksum="79C4F5CC708045D1" modified="2019-12-11" version="1">MRQFNTSSQDFILLGFSDWPLWNISSFSIPPCFFFLCHLSFLDLCYTTSIVPQLLVNLHGFDRTITKGGCVAQLFISLALGSTECVLLVVMAFACYAAVCRPFHYTTIMQPWLCLLLASISWFGGFVNSVAQRGLMMAMPLCGLCYLDHFFCEMPMPVFLKLACKDTKDTEAKMFVARVIIMVLPASLLLVSYVYLVQTVLNIKSAEGQRKAFETCGSHLMVVFLFYGSAIYTYLQPTHSYSTSHGKFAALFYTIITPMLNPFIYTLRNTDMKAALRKVIKRKRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4G2</accession>
    <name>A0A5F8G4G2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin-dependent peroxide reductase, mitochondrial</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin-dependent peroxiredoxin 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PRDX3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer; disulfide-linked, upon oxidation. 6 homodimers assemble to form a ring-like dodecamer. Interacts with NEK6. Interacts with LRRK2. Interacts with MAP3K13. Interacts with RPS6KC1 (via PX domain).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4G2"/>
    <dbReference type="Ensembl" id="ENSMODT00000073922.1">
        <property type="protein sequence ID" value="ENSMODP00000042329.1"/>
        <property type="gene ID" value="ENSMODG00000009286.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153430"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009286">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="53"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="246" mass="26829" checksum="022F6BABA1165E95" modified="2019-12-11" version="1">MEVARHVSSFPLGISAAFRPVATRNKFPANVVLTSAASPKSSAFSTSASAYVPAVTQHAPHFKGTAVVNGEFKEISLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVIAVSVDSQFSHLAWINTPRKSGGLGHMNIALLSDLTKQISRDYGVLLEGPGLALRGLFIIDPNGVIKHMSINDLPVGRSVEETLRLVKAFQFVEAHGEVCPANWTPDSPTIKPSPTASKEYFEKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4G4</accession>
    <name>A0A5F8G4G4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SLC4A2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogencarbonate(in) + chloride(out) = hydrogencarbonate(out) + chloride(in)</text>
            <dbReference type="Rhea" id="RHEA:72363"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4G4"/>
    <dbReference type="Ensembl" id="ENSMODT00000056295.1">
        <property type="protein sequence ID" value="ENSMODP00000042368.1"/>
        <property type="gene ID" value="ENSMODG00000004225.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158259"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004225">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140900">
        <property type="term" value="F:chloride:bicarbonate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000004">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001717">
        <property type="entry name" value="Anion_exchange"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002978">
        <property type="entry name" value="Anion_exchange_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018241">
        <property type="entry name" value="Anion_exchange_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF14">
        <property type="entry name" value="ANION EXCHANGE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00165">
        <property type="entry name" value="ANIONEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01188">
        <property type="entry name" value="ANIONEXHNGR2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00219">
        <property type="entry name" value="ANION_EXCHANGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00220">
        <property type="entry name" value="ANION_EXCHANGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0039">Anion exchange</keyword>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="725"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="800"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="872"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="905"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="962"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1002"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1062"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1087"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="21">
        <location>
            <begin position="308"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="20">
        <location>
            <begin position="654"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1195" mass="132046" checksum="98376DFA9EB24669" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G4G6</accession>
    <name>A0A5F8G4G6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Src kinase associated phosphoprotein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SKAP1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G4G6"/>
    <dbReference type="Ensembl" id="ENSMODT00000078031.1">
        <property type="protein sequence ID" value="ENSMODP00000042347.1"/>
        <property type="gene ID" value="ENSMODG00000012360.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017856"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012360">
        <property type="expression patterns" value="Expressed in spermatocyte and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037781">
        <property type="entry name" value="SKAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129:SF1">
        <property type="entry name" value="SRC KINASE-ASSOCIATED PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129">
        <property type="entry name" value="SRC-ASSOCIATED ADAPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="149" mass="17005" checksum="1A991DC009E52A4D" modified="2019-12-11" version="1">MQAAVTLPEEIRWLLEDVEDYLVEGLQNENLSTSAWENRDAILRGFQKIKARYHLDFQPRGGDQPENYSGHDSSEDNPSGVHGPFLMSDASFMSDYQDEDGMSHLEKRKLNSLNPLTCPPFPNPSTKFGIPSEYLWDTAFMSFNFPVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5E0</accession>
    <name>A0A5F8G5E0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Ribosomal protein S6 kinase beta-1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">70 kDa ribosomal protein S6 kinase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Synapse</location>
            <location evidence="19">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5E0"/>
    <dbReference type="Ensembl" id="ENSMODT00000076204.1">
        <property type="protein sequence ID" value="ENSMODP00000042708.1"/>
        <property type="gene ID" value="ENSMODG00000014313.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154203"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014313">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05584">
        <property type="entry name" value="STKc_p70S6K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001128">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000092">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016238">
        <property type="entry name" value="Ribosomal_S6_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000605">
        <property type="entry name" value="Ribsml_S6_kin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="14 25 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 25 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 27" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0770">Synapse</keyword>
    <keyword evidence="8" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="89"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="30">
        <location>
            <begin position="351"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="24">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="95"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25 26">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00042818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="449" mass="50544" checksum="DA91801AF8B0ED5C" modified="2019-12-11" version="1">MRRRRRRDGFYPAPDFRDGEAEAMAGVFDIDLDQPEDAGSEDELEEGGQLSESMDHGGVAECGMEHCEKFEISETSVNKGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSAAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5E2</accession>
    <name>A0A5F8G5E2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Polymeric immunoglobulin receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts (mainly via CDR1-like domain) with dimeric IgA. Interacts (mainly via CDR2-like domain) with pentameric IgM.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5E2"/>
    <dbReference type="Ensembl" id="ENSMODT00000079755.1">
        <property type="protein sequence ID" value="ENSMODP00000042636.1"/>
        <property type="gene ID" value="ENSMODG00000002141.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161667"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002141">
        <property type="expression patterns" value="Expressed in uterine wall and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05716">
        <property type="entry name" value="IgV_pIgR_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050671">
        <property type="entry name" value="CD300_family_receptors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860:SF82">
        <property type="entry name" value="POLYMERIC IMMUNOGLOBULIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860">
        <property type="entry name" value="POLYMERIC-IMMUNOGLOBULIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="381"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="488"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="599"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="766" mass="84272" checksum="728AB5CC277A94F6" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5E4</accession>
    <name>A0A5F8G5E4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase makorin-2</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase makorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MKRN2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_056660652.1">
        <property type="nucleotide sequence ID" value="XM_056804674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5E4"/>
    <dbReference type="Ensembl" id="ENSMODT00000078048.1">
        <property type="protein sequence ID" value="ENSMODP00000042713.1"/>
        <property type="gene ID" value="ENSMODG00000006280.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100025193"/>
    <dbReference type="CTD" id="23609"/>
    <dbReference type="GeneTree" id="ENSGT00950000183077"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006280">
        <property type="expression patterns" value="Expressed in testis and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16731">
        <property type="entry name" value="RING-HC_MKRN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000117">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase makorin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF17">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MAKORIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="239"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="439" mass="48825" checksum="060C4ABF4335D8E1" modified="2019-12-11" version="1">MSTKQVTCRYFMHGVCREGSQCLFSHDLSTSKPSTVCKFYQKGYCAYGSRCRYDHMRPAAATSGSAHSAGPPSLPSPVFHSPHPPPDLTASIMKSSLHEPGKREKRTLVLRDRNLCGLTEEKAKPCAVNDPGGCSDSNDSLEMKPHSYLEAIRSGLDDLEAGSSDSNEQQLCPYAAAGECHFGDACVYLHGDVCEICRLQVLHPFDSEQRKTHEKLCMASFEHDMEKAFAFQASQEKVCSICMEVVYEKPSASERRFGILSSCNHTYCLSCIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGGKCLYLHAYPDGTRAEPEKPRKQLSSEGTVRVRSCEGGRWLGWAVAFQNAAYSIHEGPSGSRPVWEASIQRGAEAQKSSGEWASCLPPSFKVGLEWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5E5</accession>
    <name>A0A5F8G5E5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LTN1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="FunCoup" id="A0A5F8G5E5">
        <property type="interactions" value="2050"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042641"/>
    <dbReference type="Ensembl" id="ENSMODT00000076962.1">
        <property type="protein sequence ID" value="ENSMODP00000042641.1"/>
        <property type="gene ID" value="ENSMODG00000020996.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016055"/>
    <dbReference type="InParanoid" id="A0A5F8G5E5"/>
    <dbReference type="OMA" id="IYGSHWE"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020996">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001251">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056241">
        <property type="entry name" value="LTN1_HEAT_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24618">
        <property type="entry name" value="LTN1_E3_ligase_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase listerin N-terminal" evidence="3">
        <location>
            <begin position="61"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase listerin HEAT-repeats region" evidence="6">
        <location>
            <begin position="1194"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase listerin HEAT repeat region" evidence="4">
        <location>
            <begin position="1379"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase listerin ubiquitin conjugating" evidence="5">
        <location>
            <begin position="1624"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1783" mass="202415" checksum="4F70514F81EFDE93" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5E6</accession>
    <name>A0A5F8G5E6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA binding protein fox-1 homolog 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Fox-1 homolog B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">RNA-binding motif protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA-binding protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RBFOX2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5E6"/>
    <dbReference type="Ensembl" id="ENSMODT00000053886.1">
        <property type="protein sequence ID" value="ENSMODP00000042682.1"/>
        <property type="gene ID" value="ENSMODG00000001122.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157534"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001122">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025670">
        <property type="entry name" value="Fox-1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047131">
        <property type="entry name" value="RBFOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597">
        <property type="entry name" value="ATAXIN 2-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597:SF31">
        <property type="entry name" value="RNA BINDING PROTEIN FOX-1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12414">
        <property type="entry name" value="Fox-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="217"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="466" mass="49275" checksum="566C55679311D887" modified="2019-12-11" version="1">MKRVFFNKIFSTPVRPAQSGPSRGIKRVFELEPPPPPPPPPPPLPAGPGPADPGPGKRLRTDEGAEGAGAPAQARPNEGAAAVGAGAGAGAGGGALQNESLTPGYHGFPARDNQGNQEPTATPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGGTQTHGEQSTNTASTQNGALTQTEGGAQTDGQQSQTQSSENTESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYIDSANSFRSDRVDMQLTDMHSLLQRQQPQPLPPPQPLTATVMAGFIQQTPTMPLPLPLATELALWRVYTEVATADLPPTEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5E7</accession>
    <name>A0A5F8G5E7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chimaerin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Chimerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CHN1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase-activating protein for p21-rac.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5E7"/>
    <dbReference type="Ensembl" id="ENSMODT00000072456.1">
        <property type="protein sequence ID" value="ENSMODP00000042634.1"/>
        <property type="gene ID" value="ENSMODG00000009464.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234635"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009464">
        <property type="expression patterns" value="Expressed in cerebellum and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20806">
        <property type="entry name" value="C1_CHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04372">
        <property type="entry name" value="RhoGAP_chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10352">
        <property type="entry name" value="SH2_a2chimerin_b2chimerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000005">
        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000019">
        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000025">
        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035840">
        <property type="entry name" value="Chimaerin_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017356">
        <property type="entry name" value="CHN1/CHN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037860">
        <property type="entry name" value="RhoGAP_chimaerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF1">
        <property type="entry name" value="N-CHIMAERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038015">
        <property type="entry name" value="N-chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="184"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="12">
        <location>
            <begin position="242"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="433" mass="50058" checksum="AA198012D22A6D4C" modified="2019-12-11" version="1">MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLSMAEGSYLIRESQRQLGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHIGYTTLNREPAYKKHMPALKDTHDWKESTGEDGVSEKRVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHITKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIDSAKTLDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVEMLIKNEDILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5E8</accession>
    <name>A0A5F8G5E8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Transient receptor potential cation channel subfamily M member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">TRPM3</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Mn(2+)(in) = Mn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28699"/>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer. Interacts with TRPM1; the interaction results in the formation of a heteromultimeric cation channel complex that are functionally different from the homomeric channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM3 sub-subfamily.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000072755.1">
        <property type="protein sequence ID" value="ENSMODP00000042690.1"/>
        <property type="gene ID" value="ENSMODG00000002750.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157366"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002750">
        <property type="expression patterns" value="Expressed in cerebellum and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1010:FF:000001">
        <property type="entry name" value="Transient receptor potential cation channel subfamily M member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1010">
        <property type="entry name" value="TRPM, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032415">
        <property type="entry name" value="TRPM_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037162">
        <property type="entry name" value="TRPM_tetra_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF7">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16519">
        <property type="entry name" value="TRPM_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="984"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1062"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="22">
        <location>
            <begin position="123"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="23">
        <location>
            <begin position="477"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="23">
        <location>
            <begin position="608"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="20">
        <location>
            <begin position="855"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM tetramerisation" evidence="21">
        <location>
            <begin position="1190"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="799"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1559"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1193"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1686" mass="192315" checksum="C4AF9E16E48E7E22" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5F1</accession>
    <name>A0A5F8G5F1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin carboxyl-terminal hydrolase 48</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Deubiquitinating enzyme 48</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin thioesterase 48</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquitin-specific-processing protease 48</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">USP48</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with TRAF2 and RELA. Interacts with GPS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5F1"/>
    <dbReference type="FunCoup" id="A0A5F8G5F1">
        <property type="interactions" value="4252"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042639"/>
    <dbReference type="Ensembl" id="ENSMODT00000080739.1">
        <property type="protein sequence ID" value="ENSMODP00000042639.1"/>
        <property type="gene ID" value="ENSMODG00000016025.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156015"/>
    <dbReference type="InParanoid" id="A0A5F8G5F1"/>
    <dbReference type="OMA" id="YLGQEKW"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016025">
        <property type="expression patterns" value="Expressed in ovary and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02668">
        <property type="entry name" value="Peptidase_C19L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01795">
        <property type="entry name" value="Ubl_USP48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000029">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 48 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033841">
        <property type="entry name" value="Pep_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044743">
        <property type="entry name" value="Ubl_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="20">
        <location>
            <begin position="89"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="21">
        <location>
            <begin position="460"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="19">
        <location>
            <begin position="930"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="613"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="881"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="896"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="908"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1049" mass="121049" checksum="266E3F2020F5FD52" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5F2</accession>
    <name>A0A5F8G5F2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcitonin receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer of CALCR and RAMP1, RAMP2 or RAMP3; the receptor complexes function as AMYR1, AMYR2 and AMYR3 receptors, respectively, and respond to amylin/IAPP, calcitonin/CT and CGRP1 ligands. Interacts with GPRASP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5F2"/>
    <dbReference type="Ensembl" id="ENSMODT00000088602.1">
        <property type="protein sequence ID" value="ENSMODP00000042646.1"/>
        <property type="gene ID" value="ENSMODG00000019674.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000169945"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019674">
        <property type="expression patterns" value="Expressed in cerebellum and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004948">
        <property type="term" value="F:calcitonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15274">
        <property type="entry name" value="7tmB1_calcitonin_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000079">
        <property type="entry name" value="Calcitonin gene-related peptide type 1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001688">
        <property type="entry name" value="GPCR_2_calcitonin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003287">
        <property type="entry name" value="GPCR_2_calcitonin_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF8">
        <property type="entry name" value="CALCITONIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00361">
        <property type="entry name" value="CALCITONINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01350">
        <property type="entry name" value="CTRFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="17">
        <location>
            <begin position="49"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="18">
        <location>
            <begin position="131"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="443" mass="49529" checksum="B165BB3397CB3A5D" modified="2019-12-11" version="1">PGLTGVLHSTQRLSSGLASILNDTEPTLEPEATTDASPERQKIVDAQFKCFERMNSKPPYKKPGLFCNRTWDGWLCWDDTPAGRLAVQGCPDYFPDFDPTGEAPHESNRTWSNYTLCNSFTSEKLKAAFVLYYMAVVGHGLSLASLLASLGILCYFKSLSCQRVTLHKNLFSSYVLNSLFTILHLVAVVPNPELVKGDPVGCKVLQFFHQYMMGCNYFWMLCQGIYLHALIVVAVFAQEQRLLCYYLLGWGFPLIPACIHANVDTPLLYIVHAPIMAALLVNFFFLLNIVRVLVTKLRDTHRAESNMYMKAVRATLILVPLLGIQFVVLPWRPESKLAGEVYDYVMHVLMHYQGLLVATIFCFFNGEVQGALRRQWAQCKAQWGQRRRDHCSTRSASCTASSLTDVPVSLCSPDSLGHRLHGKLAATAEDAELTALRSGETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5F4</accession>
    <name>A0A5F8G5F4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ARAP3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5F4"/>
    <dbReference type="Ensembl" id="ENSMODT00000073384.1">
        <property type="protein sequence ID" value="ENSMODP00000042723.1"/>
        <property type="gene ID" value="ENSMODG00000010533.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158869"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010533">
        <property type="expression patterns" value="Expressed in heart and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13253">
        <property type="entry name" value="PH1_ARAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000128">
        <property type="entry name" value="arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000057">
        <property type="entry name" value="Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000193">
        <property type="entry name" value="arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052227">
        <property type="entry name" value="Arf-Rho-GAP_ANK-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899:SF4">
        <property type="entry name" value="ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="248"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="355"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="5">
        <location>
            <begin position="441"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="920" mass="100475" checksum="5E7C959C384A8D7D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5F5</accession>
    <name>A0A5F8G5F5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sorting nexin 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SNX29</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5F5"/>
    <dbReference type="Ensembl" id="ENSMODT00000061829.1">
        <property type="protein sequence ID" value="ENSMODP00000042692.1"/>
        <property type="gene ID" value="ENSMODG00000004747.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000110975"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004747">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07277">
        <property type="entry name" value="PX_RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17689">
        <property type="entry name" value="RUN_SNX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047329">
        <property type="entry name" value="RUN_SNX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037916">
        <property type="entry name" value="SNX29_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47194:SF4">
        <property type="entry name" value="SORTING NEXIN-29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47194">
        <property type="entry name" value="SORTING NEXIN-29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="4">
        <location>
            <begin position="37"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="620"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="779" mass="87761" checksum="A1BDF059A3A2D61B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5F6</accession>
    <name>A0A5F8G5F6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RNF31</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RBR family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5F6"/>
    <dbReference type="Ensembl" id="ENSMODT00000079957.1">
        <property type="protein sequence ID" value="ENSMODP00000042651.1"/>
        <property type="gene ID" value="ENSMODG00000003397.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064112"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003397">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19815">
        <property type="entry name" value="Bbox1_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20337">
        <property type="entry name" value="BRcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16631">
        <property type="entry name" value="mRING-HC-C4C4_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20351">
        <property type="entry name" value="Rcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000015">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF31 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047543">
        <property type="entry name" value="Bbox1_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047540">
        <property type="entry name" value="BRcat_RBR_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047542">
        <property type="entry name" value="Rcat_RBR_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026254">
        <property type="entry name" value="RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032065">
        <property type="entry name" value="RNF31-UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041031">
        <property type="entry name" value="RNF31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040641">
        <property type="entry name" value="RNF31_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047541">
        <property type="entry name" value="RNF31_RBR_mRING-HC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057426">
        <property type="entry name" value="RNF31_UBA_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004">
        <property type="entry name" value="RING FINGER PROTEIN 31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18091">
        <property type="entry name" value="E3_UbLigase_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18486">
        <property type="entry name" value="PUB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16678">
        <property type="entry name" value="UBA_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25163">
        <property type="entry name" value="UBA_RNF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="12">
        <location>
            <begin position="216"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="615"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="992" mass="110788" checksum="CB67FF024E7CC973" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5F7</accession>
    <name>A0A5F8G5F7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="19">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">RHOT1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Can hydrolyze GTP, ATP and UTP.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Promotes mitochondrial fission during high calcium conditions. Can hydrolyze GTP, ATP and UTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>UTP + H2O = UDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64900"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:64901"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules. Interacts with RAP1GDS1. Interacts with ARMCX1. Found in a complex with KIF5B, OGT, RHOT2 and TRAK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Mitochondrion outer membrane</location>
            <topology evidence="1 19">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="19"/>
    <dbReference type="RefSeq" id="XP_056675445.1">
        <property type="nucleotide sequence ID" value="XM_056819467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5F7"/>
    <dbReference type="Ensembl" id="ENSMODT00000074990.1">
        <property type="protein sequence ID" value="ENSMODP00000042644.1"/>
        <property type="gene ID" value="ENSMODG00000019189.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022962"/>
    <dbReference type="CTD" id="55288"/>
    <dbReference type="GeneTree" id="ENSGT00940000155641"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019189">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034643">
        <property type="term" value="P:establishment of mitochondrion localization, microtubule-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000021">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000170">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000248">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 19 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 19" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="22">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="22">
        <location>
            <begin position="416"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="659" mass="75442" checksum="D6E86CAC51E8918D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5G0</accession>
    <name>A0A5F8G5G0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid desaturase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FADS3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5G0"/>
    <dbReference type="Ensembl" id="ENSMODT00000078447.1">
        <property type="protein sequence ID" value="ENSMODP00000042649.1"/>
        <property type="gene ID" value="ENSMODG00000007513.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182990"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007513">
        <property type="expression patterns" value="Expressed in lung and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF11">
        <property type="entry name" value="FATTY ACID DESATURASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="6">
        <location>
            <begin position="113"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="324" mass="37417" checksum="88F1E69EADEB713D" modified="2019-12-11" version="1">MAKVLLPSTVGLCVLIAHMPLFPTQDAFHAFHQDLYFVRKFLKPLLIGELAPGEPSQDRGQNEQLIEDFRALRRAAKDMKLFEADPEFFSLVVGHILLMEGLAWLVVYFLGTGWVPTILAAVVLAISQAQCWCLQHDLGHVSVFKKSRWNYVAQQFVMGQLKGFSAHWWNFRHFQHHSKPNVFHKDPDVTVAPVFLLGESSVEYGKKKRRYLPYNHQHQYFFLIGPPLLTLVNFEVENLAYMLVCMKWADLVWALSFYIRFFSSYVLFPTMPRHNYHKIAPLVKALCAKHGLNYEVKPFLRALVDIIGSLKKSGDAWLEAYLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5G1</accession>
    <name>A0A5F8G5G1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bifunctional apoptosis regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BFAR</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5G1"/>
    <dbReference type="Ensembl" id="ENSMODT00000078135.1">
        <property type="protein sequence ID" value="ENSMODP00000042733.1"/>
        <property type="gene ID" value="ENSMODG00000004930.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005386"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004930">
        <property type="expression patterns" value="Expressed in blood and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16497">
        <property type="entry name" value="RING-HC_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000331">
        <property type="entry name" value="Bifunctional apoptosis regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898:SF13">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="225" mass="25571" checksum="56DDD01C5ED4CCE7" modified="2019-12-11" version="1">MEDIQIIAPNMMKTEEETIPGISRQISVSEFSCHCCYDILVNPTTLNCGHSFCRHCLALWWVSSKKTECPECREKWEGFPKVNILLRDAIEKLFPDAIKLRSEDIQQNNDIVHSLAAFHKYGNDQISITPNAGRANPQRGGGFFSGVLTALTGVAVVLLVYHWSSRESEHDLLVHKSVAKWTAEEVIFWLEQLGPWASLYRERFLSERVNGRLSTQASHYSCCMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5G4</accession>
    <name>A0A5F8G5G4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch like family member 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KLHL10</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5G4"/>
    <dbReference type="Ensembl" id="ENSMODT00000056377.1">
        <property type="protein sequence ID" value="ENSMODP00000042654.1"/>
        <property type="gene ID" value="ENSMODG00000014695.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154664"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014695">
        <property type="expression patterns" value="Expressed in spermatid and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd18450">
        <property type="entry name" value="BACK_KLHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18240">
        <property type="entry name" value="BTB_POZ_KLHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000101">
        <property type="entry name" value="kelch-like protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030608">
        <property type="entry name" value="KLHL10_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF172">
        <property type="entry name" value="KELCH-LIKE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="634" mass="71989" checksum="B5086963F8D2A601" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5G5</accession>
    <name>A0A5F8G5G5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transient receptor potential cation channel subfamily M member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TRPM3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000077698.1">
        <property type="protein sequence ID" value="ENSMODP00000042697.1"/>
        <property type="gene ID" value="ENSMODG00000002750.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157366"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002750">
        <property type="expression patterns" value="Expressed in cerebellum and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1010">
        <property type="entry name" value="TRPM, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032415">
        <property type="entry name" value="TRPM_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037162">
        <property type="entry name" value="TRPM_tetra_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF7">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16519">
        <property type="entry name" value="TRPM_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="852"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="921"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="985"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="13">
        <location>
            <begin position="77"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="14">
        <location>
            <begin position="387"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="14">
        <location>
            <begin position="538"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="11">
        <location>
            <begin position="792"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM tetramerisation" evidence="12">
        <location>
            <begin position="1114"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1485"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="736"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1612" mass="183925" checksum="028BD4CD853B28AC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5G7</accession>
    <name>A0A5F8G5G7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CLCN7</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5G7"/>
    <dbReference type="Ensembl" id="ENSMODT00000067460.1">
        <property type="protein sequence ID" value="ENSMODP00000042659.1"/>
        <property type="gene ID" value="ENSMODG00000016179.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158458"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016179">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062158">
        <property type="term" value="F:chloride:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03685">
        <property type="entry name" value="ClC_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000018">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002249">
        <property type="entry name" value="CIC-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF136">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01118">
        <property type="entry name" value="CLCHANNEL7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="614"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="724"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="788" mass="87496" checksum="077E6808D032A949" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5G9</accession>
    <name>A0A5F8G5G9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">CCR4-NOT transcription complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CNOT10</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CNOT10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5G9"/>
    <dbReference type="Ensembl" id="ENSMODT00000065656.1">
        <property type="protein sequence ID" value="ENSMODP00000042702.1"/>
        <property type="gene ID" value="ENSMODG00000015222.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001827"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015222">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039740">
        <property type="entry name" value="CNOT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979:SF5">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="809" mass="88954" checksum="D8C235B9EB3EEFD1" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVI1</accession>
    <name>A0A5F8GVI1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Roundabout guidance receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ROBO1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVI1"/>
    <dbReference type="Ensembl" id="ENSMODT00000066257.1">
        <property type="protein sequence ID" value="ENSMODP00000051364.1"/>
        <property type="gene ID" value="ENSMODG00000016857.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154477"/>
    <dbReference type="OMA" id="LHCNSIH"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016857">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035385">
        <property type="term" value="P:Roundabout signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07693">
        <property type="entry name" value="IgC_1_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05724">
        <property type="entry name" value="IgI_2_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05725">
        <property type="entry name" value="IgI_3_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000053">
        <property type="entry name" value="Roundabout guidance receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000026">
        <property type="entry name" value="roundabout homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000043">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032986">
        <property type="entry name" value="Robo1_Ig-like3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF37">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="60"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="162"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="254"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="401" mass="44829" checksum="CEDA0B4742E50BA6" modified="2019-12-11" version="1">MCVCASVADPQIWGRVTPSWNETACRRHARTMIAESAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDSRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYICVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWRKDGSPLDDRDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVEDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVMAGDMGSYTCVAENMVGKAEASATLTVQVVSGKLTFYWPSSNHRLTVTGTSLPLSIHTPPCPSTNQLPCFTCPWQQRQTAQTKLCRKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVI2</accession>
    <name>A0A5F8GVI2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bridge-like lipid transfer protein family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BLTP1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVI2"/>
    <dbReference type="Ensembl" id="ENSMODT00000069936.1">
        <property type="protein sequence ID" value="ENSMODP00000051653.1"/>
        <property type="gene ID" value="ENSMODG00000018913.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00640000091487"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018913">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047104">
        <property type="entry name" value="BLTP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20413">
        <property type="entry name" value="BLTP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="316" mass="37176" checksum="3C8C42B085E086AA" modified="2019-12-11" version="1">MDQRKNESFVPSITQLEDFLTEHNSNVVWLLVATILSCGWIIYLTYYNSRNVGLILTLVLNRWYKNGYIHIGSFSFSVLSGKVMVREIYYITEDMSVRIQDGFIIFRWWKMYNPKQKQHDPKAETRLYITVNDFEFHVYNRSDLYGQLQELFGLEPTIIPSKKDNERVLENGRERTRPNIERVKVRTESQDPSSSWRSLIPVIKVNVSTGRLAFGNHYQPQTLCINFDDAFLTYTTKPPSSHLDQFMHIVKGKLENVRVMLVPSPRYVGLQNDEPPRLMGEGFVVMQSNDVDIYYYMDEPGRLLCLKKMRKIWSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVI4</accession>
    <name>A0A5F8GVI4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ATP6V1H</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Clathrin-coated vesicle membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVI4"/>
    <dbReference type="Ensembl" id="ENSMODT00000075305.1">
        <property type="protein sequence ID" value="ENSMODP00000051517.1"/>
        <property type="gene ID" value="ENSMODG00000009431.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003289"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009431">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00256">
        <property type="entry name" value="VATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000067">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="9">
        <location>
            <begin position="331"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="482" mass="56065" checksum="7F2663CB3849E882" modified="2019-12-11" version="1">MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISGEDCEFIQRFEMKRSPEEMQEMLQTEGSQCAKTFINLMTHISKEQTVQYILTLVDDMLQENHQRVSIFFDYAKRSKTTAWSYFLPMLNRQDLFTVHMAARIIAKLAVWGKELMEGSDLNYYFNWIKTQLSSQSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQYQMIFSIWLLAFSPQMCEHLRCYNIIPVLSDILQESVKEKVTRIILAAFRNLLEKSTEKETRQEYALAMIQCKVLKQLENLDQQKYDDEDISEDIKFLLNKLGESVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAIRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWYVRAFFSLSSIIAKISDFAFSVQKILYLNISKKDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVI5</accession>
    <name>A0A5F8GVI5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras protein specific guanine nucleotide releasing factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RASGRF2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVI5"/>
    <dbReference type="Ensembl" id="ENSMODT00000087693.1">
        <property type="protein sequence ID" value="ENSMODP00000051216.1"/>
        <property type="gene ID" value="ENSMODG00000020263.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155679"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020263">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13261">
        <property type="entry name" value="PH_RasGRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000005">
        <property type="entry name" value="Ras-specific guanine nucleotide-releasing factor 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000176">
        <property type="entry name" value="ras-specific guanine nucleotide-releasing factor 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="243"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="564" mass="65275" checksum="E2B9EF554335E5F4" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVI6</accession>
    <name>A0A5F8GVI6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVI6"/>
    <dbReference type="Ensembl" id="ENSMODT00000072785.1">
        <property type="protein sequence ID" value="ENSMODP00000051369.1"/>
        <property type="gene ID" value="ENSMODG00000046303.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00980000198589"/>
    <dbReference type="OMA" id="ARAMNEC"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000046303">
        <property type="expression patterns" value="Expressed in blood and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33426">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33426:SF46">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN IPI1 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="348" mass="38975" checksum="CC585E44DA07FB12" modified="2019-12-11" version="1">MYSKFGALTECLSTLLAFIRFLSSVNSLMLRKARAMNECLSTLFAFVRFLSSVNSLMLKKTRVLGECLSTMLALIRFLPSVDSLMYNKMKALTECLSTMLAFIRFLPSMDSLMFNMMGSLTECLSTLFAFIRFLPSVVSLMYSKTGSLTECLSTLFAFIRFLSSVDSLMFTMMGSLAECLSTLFTFIWFLPSVDSLMYSKTGSLTECLSTLLAFIRFLSSVNSLMLSKTRALGECLSTMTASIRFFTSVDSLMYSKMESLTECLSTLLAFIRFLTSVDSLMFNMMGSLTECLSTLFAFIRFFSSVNSLMLSKTRTLAECLSTLLAFIRFLSSVDSLMYNKTGVLSECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVI7</accession>
    <name>A0A5F8GVI7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 4E nuclear import factor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVI7"/>
    <dbReference type="Ensembl" id="ENSMODT00000059610.1">
        <property type="protein sequence ID" value="ENSMODP00000051658.1"/>
        <property type="gene ID" value="ENSMODG00000009732.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012071"/>
    <dbReference type="OMA" id="LIEWRSR"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009732">
        <property type="expression patterns" value="Expressed in ovary and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018862">
        <property type="entry name" value="eIF4E-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12269">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12269:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10477">
        <property type="entry name" value="EIF4E-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39793" checksum="FE1B78D8544CCFFB" modified="2019-12-11" version="1">MSQLELQHPALEGLNLPHEVAMQAAASFYQPGFGKPQMDKSRDGFRNRQQRVAKSPAPVHRGNSASPAPTAAVTSMLSPSFTPTSVIRRMYESKEKNKEDPISGKPASDGKEEGQRANEENLLLSSMANSDRDTSPTMNPKLSTLQRSASSTPLSQASRYTKEQDYRPKAAGRKTPTLASPVPGAPFLRPVHQVPLVSHVPIVRPAHQFHPGLVQRMLAQGVHPQHLPTLLQAGMLPPGMDLSHLQGISGPLLGQPFYPLPAASHPLLTPRSGTPLQLAVMQQQLQRSVLHPPGSGSQGTAIGVQTPPQNLSGRPGLPHIPPQLEHRPSQRSTSPVGLAKWFGSDVLQQPLPSMPSKVISVDELEYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVI9</accession>
    <name>A0A5F8GVI9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">FAT atypical cadherin 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000088023.1">
        <property type="protein sequence ID" value="ENSMODP00000051522.1"/>
        <property type="gene ID" value="ENSMODG00000005018.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157733"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005018">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000013">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000152">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000154">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000179">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000021">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000026">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000032">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000037">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000051">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000052">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000064">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000065">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000067">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000075">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000079">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000080">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000089">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000107">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000161">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000053">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000058">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000059">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000061">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000084">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000057">
        <property type="entry name" value="protocadherin Fat 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000035">
        <property type="entry name" value="Protocadherin Fat 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023891809" description="FAT atypical cadherin 1" evidence="16">
        <location>
            <begin position="23"/>
            <end position="4494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="4088"/>
            <end position="4108"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="151"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="369"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="465"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="578"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="719"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="824"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="990"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1087"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1193"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1378"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1468"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1573"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1671"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1785"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1885"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1987"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2088"/>
            <end position="2188"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2189"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2297"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2399"/>
            <end position="2502"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2503"/>
            <end position="2609"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2610"/>
            <end position="2715"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2716"/>
            <end position="2824"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2825"/>
            <end position="2929"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2930"/>
            <end position="3031"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="3032"/>
            <end position="3136"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="3137"/>
            <end position="3241"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="3242"/>
            <end position="3346"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="3347"/>
            <end position="3451"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="3467"/>
            <end position="3553"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3696"/>
            <end position="3733"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="3735"/>
            <end position="3915"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3919"/>
            <end position="3956"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3958"/>
            <end position="3994"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3995"/>
            <end position="4031"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="4033"/>
            <end position="4069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4162"/>
            <end position="4186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4210"/>
            <end position="4233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4336"/>
            <end position="4385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4401"/>
            <end position="4423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4470"/>
            <end position="4494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="4162"/>
            <end position="4171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="4341"/>
            <end position="4359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="4407"/>
            <end position="4418"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="3705"/>
            <end position="3722"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="3946"/>
            <end position="3955"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="3984"/>
            <end position="3993"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="4021"/>
            <end position="4030"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="4059"/>
            <end position="4068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4494" mass="497968" checksum="2A01A8D40178EE4A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVJ2</accession>
    <name>A0A5F8GVJ2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Caspase recruitment domain-containing protein 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Bcl10-interacting CARD protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CARD19</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Associates with BCL10 by CARD-CARD interaction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_016279798.1">
        <property type="nucleotide sequence ID" value="XM_016424312.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVJ2"/>
    <dbReference type="Ensembl" id="ENSMODT00000062242.1">
        <property type="protein sequence ID" value="ENSMODP00000051555.1"/>
        <property type="gene ID" value="ENSMODG00000014342.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100023648"/>
    <dbReference type="CTD" id="84270"/>
    <dbReference type="GeneTree" id="ENSGT00940000164282"/>
    <dbReference type="OrthoDB" id="8810754at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014342">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13785">
        <property type="entry name" value="CARD_BinCARD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000015">
        <property type="entry name" value="Caspase recruitment domain-containing protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043574">
        <property type="entry name" value="CARD19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042146">
        <property type="entry name" value="CARD_BinCARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34765">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34765:SF1">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="CARD" evidence="13">
        <location>
            <begin position="44"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="166" mass="19497" checksum="1A8FD3C4276CC1EC" modified="2019-12-11" version="1">MFCRKYQTYCDRLVQDTPFLTSNGRLNEQQVDKIILQLNRFYPQILTNKEAEKFRNPKTSLRIRLSDLLTHLQRKGERDCQEFYRALYINAQHLYGSLPSRKAMSPMFFLACFSVAAGLAFLIYYCSPDPRVFRGARRVIGFSPIIIGKHVSHYLLAYLEKSFREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVJ3</accession>
    <name>A0A5F8GVJ3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nostrin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nitric oxide synthase trafficker</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">NOSTRIN</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056649956.1">
        <property type="nucleotide sequence ID" value="XM_056793978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVJ3"/>
    <dbReference type="Ensembl" id="ENSMODT00000058299.1">
        <property type="protein sequence ID" value="ENSMODP00000051663.1"/>
        <property type="gene ID" value="ENSMODG00000007742.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100017122"/>
    <dbReference type="CTD" id="115677"/>
    <dbReference type="GeneTree" id="ENSGT00510000048120"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007742">
        <property type="expression patterns" value="Expressed in spermatid and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11823">
        <property type="entry name" value="SH3_Nostrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000186">
        <property type="entry name" value="Nitric oxide synthase trafficking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035656">
        <property type="entry name" value="Nostrin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="20">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="397"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="465" mass="52795" checksum="B3849CA402AFDF2A" modified="2019-12-11" version="1">MKDPLTNCSYNKVYKELKEVSQNGENFCKQLTSILQQRANLEISYAKGLQKLASKLTKALQSTKKNCICGAWAFASESMKSAADLHQKLGKAIQSEAIKPTHQVLSAQEKKKRTLDNEVEKMANLVMNNWSQQIKAKKKLMVETKKHEALFHSVERTKQSVTEKEKRKLLGKLKKSTEKLAKEDESYYQKNIAGYTTRLKWEVTLQNCYQNVLDLEKERIQLLCNILNQYNQHVSIFGQTLTTGHTQLHCAISKIDVEKDIRTLMEETSISTTEEKSEFLLTDYFEEDPTNGMDKERRKSSIKSKLSRLKEDIEKASRDKEGLERMINVYTANPSFTDAKTKKETAVLIDEDQTHSSVKISRPFMTKKLENVVRRTSSSGLLNNPGSVPLASGITSLGNGTCQALYPFQARGDDELNLEKGDIVTIYEKQNEGWWFGSLRGKKGHFPSAYVEELPLNNGELSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVJ4</accession>
    <name>A0A5F8GVJ4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thrombospondin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">THBS3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomer; disulfide-linked.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thrombospondin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVJ4"/>
    <dbReference type="Ensembl" id="ENSMODT00000071275.1">
        <property type="protein sequence ID" value="ENSMODP00000051527.1"/>
        <property type="gene ID" value="ENSMODG00000017093.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159283"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017093">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd16079">
        <property type="entry name" value="TSP-3cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1080.10:FF:000004">
        <property type="entry name" value="Cartilage oligomeric matrix protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000025">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000027">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1080.10:FF:000001">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000170">
        <property type="entry name" value="thrombospondin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000232">
        <property type="entry name" value="thrombospondin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000038">
        <property type="entry name" value="thrombospondin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.10:FF:000001">
        <property type="entry name" value="thrombospondin-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017897">
        <property type="entry name" value="Thrombospondin_3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008859">
        <property type="entry name" value="Thrombospondin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024665">
        <property type="entry name" value="TSP/COMP_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046970">
        <property type="entry name" value="TSP/COMP_CC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028507">
        <property type="entry name" value="TSP3_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199">
        <property type="entry name" value="THROMBOSPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199:SF89">
        <property type="entry name" value="THROMBOSPONDIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11598">
        <property type="entry name" value="COMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05735">
        <property type="entry name" value="TSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58006">
        <property type="entry name" value="Assembly domain of cartilage oligomeric matrix protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51234">
        <property type="entry name" value="TSP3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51236">
        <property type="entry name" value="TSP_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023825583" description="Thrombospondin-3" evidence="15">
        <location>
            <begin position="22"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="13">
        <location>
            <begin position="482"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="13">
        <location>
            <begin position="541"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="13">
        <location>
            <begin position="678"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="TSP C-terminal" evidence="17">
        <location>
            <begin position="717"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="537"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="828" mass="89728" checksum="7DF93FF630AB9E3C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GVJ6</accession>
    <name>A0A5F8GVJ6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sodium channel and clathrin linker 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SCLT1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GVJ6"/>
    <dbReference type="Ensembl" id="ENSMODT00000077960.1">
        <property type="protein sequence ID" value="ENSMODP00000051668.1"/>
        <property type="gene ID" value="ENSMODG00000020760.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111168"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020760">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045162">
        <property type="term" value="P:clustering of voltage-gated sodium channels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038911">
        <property type="entry name" value="SCLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35970">
        <property type="entry name" value="SODIUM CHANNEL AND CLATHRIN LINKER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35970:SF1">
        <property type="entry name" value="SODIUM CHANNEL AND CLATHRIN LINKER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="623" mass="73439" checksum="94D4748377462175" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWH2</accession>
    <name>A0A5F8GWH2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphodiesterase</fullName>
            <ecNumber evidence="15">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PDE6C</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWH2"/>
    <dbReference type="Ensembl" id="ENSMODT00000053728.1">
        <property type="protein sequence ID" value="ENSMODP00000051915.1"/>
        <property type="gene ID" value="ENSMODG00000005884.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157825"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005884">
        <property type="expression patterns" value="Expressed in placenta and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000005">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000001">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000010">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0140">cGMP</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0844">Vision</keyword>
    <feature type="domain" description="PDEase" evidence="17">
        <location>
            <begin position="479"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="823"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="555"/>
            <end position="559"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="716"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="716"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="769"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="854" mass="99189" checksum="33059F1FC2E2070B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWH5</accession>
    <name>A0A5F8GWH5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Resistin like beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RETNLB</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistin/FIZZ family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWH5"/>
    <dbReference type="Ensembl" id="ENSMODT00000063095.1">
        <property type="protein sequence ID" value="ENSMODP00000051714.1"/>
        <property type="gene ID" value="ENSMODG00000018074.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016177"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018074">
        <property type="expression patterns" value="Expressed in lung and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16333">
        <property type="entry name" value="RELM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4230:FF:000001">
        <property type="entry name" value="Resistin-like beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4230">
        <property type="entry name" value="Resistin head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009714">
        <property type="entry name" value="RELM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036262">
        <property type="entry name" value="Resistin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21101">
        <property type="entry name" value="RESISTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21101:SF13">
        <property type="entry name" value="RESISTIN-LIKE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06954">
        <property type="entry name" value="Resistin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111423">
        <property type="entry name" value="Resistin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023925788" evidence="7">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="109" mass="11673" checksum="2D0C7965E6F10561" modified="2019-12-11" version="1">MKPAFFLLLILIPLLALMSPGHADCTLDSIVDKKIKESLTSLELGFQARLTCTSVKSRGTLATCPAGFIVTGCACGYGCGSWDVRGDNVCHCQCSGMDWTSARCCQFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWH6</accession>
    <name>A0A5F8GWH6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphodiesterase</fullName>
            <ecNumber evidence="15">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PDE6C</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWH6"/>
    <dbReference type="Ensembl" id="ENSMODT00000068750.1">
        <property type="protein sequence ID" value="ENSMODP00000051496.1"/>
        <property type="gene ID" value="ENSMODG00000005884.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157825"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005884">
        <property type="expression patterns" value="Expressed in placenta and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000005">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000001">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000010">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0140">cGMP</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0844">Vision</keyword>
    <feature type="domain" description="PDEase" evidence="17">
        <location>
            <begin position="463"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="791"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="551"/>
            <end position="555"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="712"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="712"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="841" mass="97659" checksum="6BC6FF98291C205B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWH8</accession>
    <name>A0A5F8GWH8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Suppressor of fused homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SUFU</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUFU family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWH8"/>
    <dbReference type="Ensembl" id="ENSMODT00000062951.1">
        <property type="protein sequence ID" value="ENSMODP00000051920.1"/>
        <property type="gene ID" value="ENSMODG00000011242.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009747"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011242">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.230">
        <property type="entry name" value="Sufu, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024314">
        <property type="entry name" value="SUFU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038489">
        <property type="entry name" value="SUFU_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037181">
        <property type="entry name" value="SUFU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007768">
        <property type="entry name" value="Suppressor_of_fused"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016591">
        <property type="entry name" value="Suppressor_of_fused_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10928">
        <property type="entry name" value="SUPPRESSOR OF FUSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10928:SF2">
        <property type="entry name" value="SUPPRESSOR OF FUSED HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12470">
        <property type="entry name" value="SUFU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011844">
        <property type="entry name" value="Suppressor_of_fused_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103359">
        <property type="entry name" value="Suppressor of Fused, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of fused-like" evidence="3">
        <location>
            <begin position="66"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Suppressor of fused C-terminal" evidence="4">
        <location>
            <begin position="255"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="461" mass="50872" checksum="6A67ABFF1402C0F9" modified="2019-12-11" version="1">MAELRPSGAPGPAAPPAPAPGPAAPPAFASLFPPGLHAIYGECRRLYPEQPNPLQVTAIVKYWLGGPDPLDYVSMYRNLGSPGANVPEHWHYVSFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGLVIFLQIVGVCTEELHAAQQWNGQGILELLRTVPVAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDDDSRSICIGMQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINTQRQNGLNHDRAPSRKDSLESESSAAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDTAITFVSTGVEGAFATEEHPYAAHGPWLQVRRPFFFSPLLSNSKALFSSSLSAASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWH9</accession>
    <name>A0A5F8GWH9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear receptor coactivator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NCOA2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Present in a complex containing CARM1 and EP300/P300. Interacts (via C-terminus) with CREBBP. Interacts (via LXXLL 1, 2 and 3 motifs) with RORA (via AF-2 motif). Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif). Interacts with APEX1. Interacts with BMAL1. Interacts with CARM1. Interacts with CASP8AP2. Interacts with CLOCK. Interacts with DDX5. Interacts with ESR1. Interacts with HIF1A. Interacts with NCOA1. Interacts with NR4A1/Nur77. Interacts with NR4A3; potentiates the activity of the NR4A3. Interacts with NR1H3. Interacts with NR3C1. Interacts with NR3C2. Interacts with PSMB9. Interacts with RARA. Interacts with RXRA. Interacts with RWDD3. Interacts with TTLL5/STAMP. Interacts with NR5A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SRC/p160 nuclear receptor coactivator family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000052538.1">
        <property type="protein sequence ID" value="ENSMODP00000051719.1"/>
        <property type="gene ID" value="ENSMODG00000007376.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183021"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007376">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18950">
        <property type="entry name" value="bHLH-PAS_NCoA2_SRC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000007">
        <property type="entry name" value="Nuclear receptor coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000008">
        <property type="entry name" value="Nuclear receptor coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000008">
        <property type="entry name" value="Nuclear receptor coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.20">
        <property type="entry name" value="Nuclear receptor coactivator, Ncoa-type, interlocking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056193">
        <property type="entry name" value="bHLH_NCOA1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010011">
        <property type="entry name" value="NCO_DUF1518"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032565">
        <property type="entry name" value="NCOA2/3_DUF4927"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028822">
        <property type="entry name" value="NCOA2_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009110">
        <property type="entry name" value="Nuc_rcpt_coact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014920">
        <property type="entry name" value="Nuc_rcpt_coact_Ncoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037077">
        <property type="entry name" value="Nuc_rcpt_coact_Ncoa_int_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017426">
        <property type="entry name" value="Nuclear_rcpt_coactivator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014935">
        <property type="entry name" value="SRC/p160_LXXLL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10684">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10684:SF2">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23172">
        <property type="entry name" value="bHLH_NCOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07469">
        <property type="entry name" value="DUF1518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16279">
        <property type="entry name" value="DUF4927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16665">
        <property type="entry name" value="NCOA_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08815">
        <property type="entry name" value="Nuc_rec_co-act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08832">
        <property type="entry name" value="SRC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038181">
        <property type="entry name" value="Nuclear_receptor_coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01151">
        <property type="entry name" value="DUF1518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69125">
        <property type="entry name" value="Nuclear receptor coactivator interlocking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="14">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="119"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="466"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="557"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1013"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1049"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1020"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1436" mass="156166" checksum="8F33780D220495D3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWI1</accession>
    <name>A0A5F8GWI1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CREB regulated transcription coactivator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CRTC2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TORC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWI1"/>
    <dbReference type="Ensembl" id="ENSMODT00000075466.1">
        <property type="protein sequence ID" value="ENSMODP00000051724.1"/>
        <property type="gene ID" value="ENSMODG00000017314.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010652"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017314">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008140">
        <property type="term" value="F:cAMP response element binding protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024786">
        <property type="entry name" value="TORC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024785">
        <property type="entry name" value="TORC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024783">
        <property type="entry name" value="TORC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589:SF6">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12886">
        <property type="entry name" value="TORC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12884">
        <property type="entry name" value="TORC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transducer of regulated CREB activity N-terminal" evidence="11">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Transducer of regulated CREB activity C-terminal" evidence="12">
        <location>
            <begin position="292"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="370" mass="38384" checksum="2387BA702A73EF80" modified="2019-12-11" version="1">MAASGPNGPGSGSGSSSASAANPRKFSEKIALQKQRQASLNSPQPQLQGSHSHPSLPASSFARHTMPATSLGHPSLSAPALSSTSSSSSPALGAPLYPTPTPGASPRHRRVPLSPLSLPMGGTDARRPQQQLPKQFSPTMSPTLSSITQGVPLDTSKLPVDQRLPPYPYSPPSLLLPTQPPVTKPMQQQPPLPQSCPVQPPGGQRHYGVSYPPDSSGQQPYAPPTGDFSLGNLEQFSMESPSGNLTMDPSSFSEGPGFSGNDEPGGGGSGPQDSHTLNRQNLTHCARHGPVPNIILTGDSPPGFSKEIAAALAGVPGFEVATAGLGLGLGLEDELRMEPLTLDGLNMLSDPYALLTDPAVEDSFRSDRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWI2</accession>
    <name>A0A5F8GWI2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tetratricopeptide repeat domain 21A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TTC21A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWI2"/>
    <dbReference type="Ensembl" id="ENSMODT00000070482.1">
        <property type="protein sequence ID" value="ENSMODP00000051925.1"/>
        <property type="gene ID" value="ENSMODG00000013468.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005979"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013468">
        <property type="expression patterns" value="Expressed in testis and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000775">
        <property type="entry name" value="Tetratricopeptide repeat domain 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000803">
        <property type="entry name" value="Tetratricopeptide repeat domain 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000245">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056832">
        <property type="entry name" value="ARM_TT21_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056835">
        <property type="entry name" value="ARM_TT21_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056834">
        <property type="entry name" value="ARM_TT21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056833">
        <property type="entry name" value="ARM_TT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF2">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25058">
        <property type="entry name" value="ARM_TT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25060">
        <property type="entry name" value="ARM_TT21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25064">
        <property type="entry name" value="ARM_TT21_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25063">
        <property type="entry name" value="ARM_TT21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25062">
        <property type="entry name" value="ARM_TT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B N-terminal ARM repeat" evidence="8">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B second ARM" evidence="7">
        <location>
            <begin position="275"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="783"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fifth ARM repeats" evidence="10">
        <location>
            <begin position="785"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B C-terminal ARM" evidence="9">
        <location>
            <begin position="900"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1113" mass="125248" checksum="E142801202433D46" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWI4</accession>
    <name>A0A5F8GWI4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Kinesin family member 21A</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000064354.1">
        <property type="protein sequence ID" value="ENSMODP00000051501.1"/>
        <property type="gene ID" value="ENSMODG00000018544.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155323"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018544">
        <property type="expression patterns" value="Expressed in blood and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22263">
        <property type="entry name" value="Rcc_KIF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000233">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000370">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000166">
        <property type="entry name" value="Kinesin family member 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056533">
        <property type="entry name" value="KIF21A/B_hel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056532">
        <property type="entry name" value="KIF21A/B_hel_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF31">
        <property type="entry name" value="KINESIN FAMILY MEMBER 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23203">
        <property type="entry name" value="KIF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23204">
        <property type="entry name" value="KIF21A_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 16" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="20">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="1139"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="1335"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="1418"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="403"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="652"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="983"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="493"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1058"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1470" mass="164910" checksum="E15469A9383A08B2" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWI7</accession>
    <name>A0A5F8GWI7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ATP6V0A1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with SPAAR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">Clathrin-coated vesicle membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003340358.1">
        <property type="nucleotide sequence ID" value="XM_003340310.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056672708.1">
        <property type="nucleotide sequence ID" value="XM_056816730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWI7"/>
    <dbReference type="FunCoup" id="A0A5F8GWI7">
        <property type="interactions" value="1959"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051930"/>
    <dbReference type="Ensembl" id="ENSMODT00000077605.1">
        <property type="protein sequence ID" value="ENSMODP00000051930.1"/>
        <property type="gene ID" value="ENSMODG00000014883.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100011213"/>
    <dbReference type="CTD" id="535"/>
    <dbReference type="GeneTree" id="ENSGT00950000182881"/>
    <dbReference type="InParanoid" id="A0A5F8GWI7"/>
    <dbReference type="OMA" id="FYLWFFL"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014883">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF68">
        <property type="entry name" value="V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="838" mass="96747" checksum="91303B505D404139" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWI9</accession>
    <name>A0A5F8GWI9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal trans-2-enoyl-CoA reductase</fullName>
            <ecNumber evidence="13">1.3.1.38</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PECR</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(2E)-decenoyl-CoA + NADPH + H(+) = decanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44960"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:44961"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2E)-dodecenoyl-CoA + NADPH + H(+) = dodecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:44965"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2E)-hexenoyl-CoA + NADPH + H(+) = hexanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44956"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:44957"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-octenoyl-CoA + NADPH + H(+) = octanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:44953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2E)-tetradecenoyl-CoA + NADPH + H(+) = tetradecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:44969"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a (2E)-enoyl-CoA + NADPH + H(+) = a 2,3-saturated acyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:33763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33764"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with PEX5, probably required to target it into peroxisomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.38" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWI9"/>
    <dbReference type="Ensembl" id="ENSMODT00000078545.1">
        <property type="protein sequence ID" value="ENSMODP00000051506.1"/>
        <property type="gene ID" value="ENSMODG00000015562.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156882"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015562">
        <property type="expression patterns" value="Expressed in liver and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019166">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000335">
        <property type="entry name" value="Peroxisomal trans-2-enoyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052388">
        <property type="entry name" value="Peroxisomal_t2-enoyl-CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24317">
        <property type="entry name" value="PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24317:SF7">
        <property type="entry name" value="PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="299" mass="32562" checksum="D90D2662A02B3D93" modified="2019-12-11" version="1">MGSKSFLAAGLLRNQVAIVTGGGTGIGKAITRELLHLDCNVVIASRKFDILKSAAEELNASQLPSNSAIVTPIQCNIRKEEEVNNLVKSTLDLHGKINFLVNNGGGQFLSPSESITSKGWNAVVETNLTGTFYLCKAVYKSWMKEHGGSIVNIIVLLNNGFPNAVHSGAARAGVENMSKTLALEWASNGIRINCVAPGITYSPTAFHNYEKVGETHFQRFYQFCPAKRYCVPEEISSLVCFLLSPAASYITGQTVCADGGLTLYSKFWDIPDHENWPDGPWDLSTVKKLKASFEAERKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWJ0</accession>
    <name>A0A5F8GWJ0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nardilysin convertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NRDC</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWJ0"/>
    <dbReference type="Ensembl" id="ENSMODT00000062813.1">
        <property type="protein sequence ID" value="ENSMODP00000051734.1"/>
        <property type="gene ID" value="ENSMODG00000000839.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100011053"/>
    <dbReference type="KEGG" id="mdo:100011053"/>
    <dbReference type="CTD" id="4898"/>
    <dbReference type="GeneTree" id="ENSGT00940000155026"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000839">
        <property type="expression patterns" value="Expressed in spermatid and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="236"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="395"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="585"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="871"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1184" mass="133827" checksum="52E33572260ED38A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWJ1</accession>
    <name>A0A5F8GWJ1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AAK1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWJ1"/>
    <dbReference type="Ensembl" id="ENSMODT00000067029.1">
        <property type="protein sequence ID" value="ENSMODP00000051877.1"/>
        <property type="gene ID" value="ENSMODG00000011819.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100032733"/>
    <dbReference type="CTD" id="22848"/>
    <dbReference type="GeneTree" id="ENSGT00940000155968"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011819">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000072">
        <property type="entry name" value="AP2 associated kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051744">
        <property type="entry name" value="AP2_assoc_SerThr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028182">
        <property type="entry name" value="BMP2K_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47907:SF5">
        <property type="entry name" value="AP2 ASSOCIATED KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47907">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15282">
        <property type="entry name" value="BMP2K_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="46"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="566"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="679"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="739"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1022"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1128"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1153" mass="124982" checksum="E2E1146A6E135A12" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWJ2</accession>
    <name>A0A5F8GWJ2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Meiotic double-stranded break formation protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MEI1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWJ2"/>
    <dbReference type="Ensembl" id="ENSMODT00000068093.1">
        <property type="protein sequence ID" value="ENSMODP00000052033.1"/>
        <property type="gene ID" value="ENSMODG00000016599.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002077"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016599">
        <property type="expression patterns" value="Expressed in cerebellum and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052133">
        <property type="entry name" value="Immune_Signaling-Apoptosis_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12044">
        <property type="entry name" value="BCL2 INTERACTING MEDIATOR OF CELL DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12044:SF10">
        <property type="entry name" value="MEIOSIS INHIBITOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000052033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1194" mass="132567" checksum="E5BACA171258AD56" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWJ5</accession>
    <name>A0A5F8GWJ5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein unc-45 homolog B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">UNC45B</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">A band</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000076468.1">
        <property type="protein sequence ID" value="ENSMODP00000051739.1"/>
        <property type="gene ID" value="ENSMODG00000019133.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157654"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019133">
        <property type="expression patterns" value="Expressed in heart and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000043">
        <property type="entry name" value="Unc-45 myosin chaperone B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000025">
        <property type="entry name" value="Unc-45 myosin chaperone B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF2">
        <property type="entry name" value="PROTEIN UNC-45 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="14">
        <location>
            <begin position="300"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1007"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1252" mass="140503" checksum="34E26D77DA2D597F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWJ6</accession>
    <name>A0A5F8GWJ6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial translation release factor 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MTRF1L</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWJ6"/>
    <dbReference type="Ensembl" id="ENSMODT00000062614.1">
        <property type="protein sequence ID" value="ENSMODP00000051882.1"/>
        <property type="gene ID" value="ENSMODG00000008487.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155683"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008487">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000011">
        <property type="entry name" value="Peptide chain release factor 1-like, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF3">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR 1-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="275" mass="31114" checksum="4D051C3443FC75F7" modified="2019-12-11" version="1">MQSLLLLRSARCLWTRGALLRTPRRPASSGSPQLEELFSGGGAMRNFLERLTGPGVQAHFGVKEPELAMAARKLREKEQELQEIERLLEDENEDLRKLAENEIISCQKELTKLKQKIILLLIPSEETDENDLILELTAGVGGQEAMLFTAEMFDMYQRYATYKKWHFEILEYFPSEIGGLRHASASIGGPEAYRHMKFEGGVHRVQRVPKTEKQGRMHTSTMTVAILPQPTEINLVINPKELRIETKRASGAGGQHVNTTDSAVRIVHLPTDWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7I0</accession>
    <name>A0A5F8H7I0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PEX5-related protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">PEX5-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peroxin-5-related protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Tetratricopeptide repeat-containing Rab8b-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PEX5L</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056663644.1">
        <property type="nucleotide sequence ID" value="XM_056807666.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_056663645.1">
        <property type="nucleotide sequence ID" value="XM_056807667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7I0"/>
    <dbReference type="Ensembl" id="ENSMODT00000066700.1">
        <property type="protein sequence ID" value="ENSMODP00000055186.1"/>
        <property type="gene ID" value="ENSMODG00000021298.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100010787"/>
    <dbReference type="KEGG" id="mdo:100010787"/>
    <dbReference type="CTD" id="51555"/>
    <dbReference type="GeneTree" id="ENSGT00940000155931"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021298">
        <property type="expression patterns" value="Expressed in cerebellum and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000012">
        <property type="entry name" value="PEX5-related protein isoform 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF1">
        <property type="entry name" value="PEX5-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="463"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="497"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="108"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="170"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="615" mass="68448" checksum="B2C5D6176F8351D9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7I2</accession>
    <name>A0A5F8H7I2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7I2"/>
    <dbReference type="Ensembl" id="ENSMODT00000081386.1">
        <property type="protein sequence ID" value="ENSMODP00000055757.1"/>
        <property type="gene ID" value="ENSMODG00000025255.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154838"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025255">
        <property type="expression patterns" value="Expressed in blood and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01469">
        <property type="entry name" value="vWA_integrins_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000005">
        <property type="entry name" value="Integrin alpha L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000004">
        <property type="entry name" value="Integrin subunit alpha M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000012">
        <property type="entry name" value="Integrin, alpha 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1460:FF:000001">
        <property type="entry name" value="Integrin, alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048633">
        <property type="entry name" value="ITGAX-like_Ig_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF118">
        <property type="entry name" value="INTEGRIN ALPHA-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00357">
        <property type="entry name" value="Integrin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21520">
        <property type="entry name" value="ITGAX-like_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0401">Integrin</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1079"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="17">
        <location>
            <begin position="155"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="444"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="507"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="570"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1131" mass="125852" checksum="97B2847312E5E4BA" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7I4</accession>
    <name>A0A5F8H7I4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pinin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PNN</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7I4"/>
    <dbReference type="Ensembl" id="ENSMODT00000061125.1">
        <property type="protein sequence ID" value="ENSMODP00000055940.1"/>
        <property type="gene ID" value="ENSMODG00000011926.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111160"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011926">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006787">
        <property type="entry name" value="Pinin_SDK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04697">
        <property type="entry name" value="Pinin_SDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="14 21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Pinin/SDK" evidence="24">
        <location>
            <begin position="37"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="23">
        <location>
            <begin position="112"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="258"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="317"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="548"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF04697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="690" mass="78888" checksum="5A4CD5FC88D58106" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7I5</accession>
    <name>A0A5F8H7I5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calaxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CLXN</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7I5"/>
    <dbReference type="Ensembl" id="ENSMODT00000059765.1">
        <property type="protein sequence ID" value="ENSMODP00000055504.1"/>
        <property type="gene ID" value="ENSMODG00000010184.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159968"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010184">
        <property type="expression patterns" value="Expressed in spermatid and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF75">
        <property type="entry name" value="CALAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="171" mass="19745" checksum="7E409A4D53D3D0B5" modified="2019-12-11" version="1">DAAEKPDCIGLDRNTFRNILHTTFGMTDDMIMDRVFRAFDRDNDGHVSVTEWVTGLCVFLRGNLEEKMKYCFEAYDLNGDGFISREEMFHMLKNSLLKQPSEEDPDEGIKDLVDITLKKMDYDHDGKLSFADYEQAVRDEGLLLEAFGPCLPDPKKHLEFEAQVFKDPHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7I7</accession>
    <name>A0A5F8H7I7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein lin-52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LIN52</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lin-52 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7I7"/>
    <dbReference type="Ensembl" id="ENSMODT00000080584.1">
        <property type="protein sequence ID" value="ENSMODP00000055945.1"/>
        <property type="gene ID" value="ENSMODG00000006397.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008402"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006397">
        <property type="expression patterns" value="Expressed in uterine wall and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070176">
        <property type="term" value="C:DRM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018737">
        <property type="entry name" value="DREAM_LIN52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489">
        <property type="entry name" value="LIN52 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489:SF2">
        <property type="entry name" value="PROTEIN LIN-52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10044">
        <property type="entry name" value="LIN52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="147" mass="16402" checksum="831E4BD595BBA24D" modified="2019-12-11" version="1">MSHCLYLGIVILGTDLEASLLSFEKLDRASPDLWPEQLPGVAEFAASFKSPITSSPPKWMAELENDDIDMLKELGSLTTANLMEKVRGLQNLAYQLGLDEWKRKQCPTDPILLEHQNLANLRSQCSPDLIARSDHLSAKEKEIIPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7I8</accession>
    <name>A0A5F8H7I8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin related protein 3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ACTR3B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7I8"/>
    <dbReference type="Ensembl" id="ENSMODT00000070899.1">
        <property type="protein sequence ID" value="ENSMODP00000055191.1"/>
        <property type="gene ID" value="ENSMODG00000004852.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158304"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004852">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000315">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000803">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000002">
        <property type="entry name" value="actin-related protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="405" mass="46469" checksum="6D7DD314DC931423" modified="2019-12-11" version="1">MMYTKLGYAGNTEPQFIIPSCIAIRESAKVVDQAQRRVLRGVDDLDFFIGDEAIDKPTYATKWPIRHGIIEDWDLMERFMEQVIFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDARKWIKQYTGINAINQKKFIIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDARLKLSEELSGGRIKPKPVEVQVITHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7J0</accession>
    <name>A0A5F8H7J0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Methyl-CpG-binding protein 2</fullName>
            <shortName evidence="12">MeCp-2 protein</shortName>
            <shortName evidence="12">MeCp2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MECP2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FNBP3. Interacts with CDKL5. Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells. Interacts with NCOR2. Interacts with TBL1XR1; bridges interaction between MECP2 and NCOR1. Interacts with TBL1X; recruits TBL1X to the heterochromatin foci.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <text evidence="12">Colocalized with methyl-CpG in the genome.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7J0"/>
    <dbReference type="Ensembl" id="ENSMODT00000069603.1">
        <property type="protein sequence ID" value="ENSMODP00000055767.1"/>
        <property type="gene ID" value="ENSMODG00000011643.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063687"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011643">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010385">
        <property type="term" value="F:double-stranded methylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000026">
        <property type="term" value="P:regulation of multicellular organismal development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01396">
        <property type="entry name" value="MeCP2_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.890.10:FF:000004">
        <property type="entry name" value="Methyl-CpG-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017353">
        <property type="entry name" value="Me_CpG-bd_MeCP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF6">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038006">
        <property type="entry name" value="Methyl_CpG_bd_MeCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MBD" evidence="14">
        <location>
            <begin position="90"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="147"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="317"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="500" mass="54221" checksum="DC513821B3775272" modified="2019-12-11" version="1">MVAGMLGLREEQSEDQDLQGLRDKPLKFRKLKRDKKEEKEGKHEFPQPSSHQSAEPAEAGKAETSEEAGSAPAAPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKSKSPKAPGTGRGRGRPKGSGTVKPRVTASEGVQVKRVIEKSPGKLLVKMPFQPSPGGKAEGGGATTSTQVMVIKRPGRKRKVETEPQVIPKKRGRKPGSIVAAAAVEAKKKAIKESSIRSIHETVLPIKKRKTREAVSIEVKEVVKPLLVSTVGEKSTKGLKPGKSPGRKSKESSPKGRSASTSSSPPKKEQQQQQQYHHHHYYPSSESPKAPPPPHPEPEGSKDSKSPPEPQDLSSKVCKEEKMPRGAPPESDGCTKELAKTQPTAAAASAAATAATATTATTAAEKFKHRAEGDRKDIVSSSMPRPNREDPVDSRTPVTERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7J1</accession>
    <name>A0A5F8H7J1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein NDRG2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">N-myc downstream-regulated gene 2 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NDRG2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7J1"/>
    <dbReference type="Ensembl" id="ENSMODT00000077591.1">
        <property type="protein sequence ID" value="ENSMODP00000055509.1"/>
        <property type="gene ID" value="ENSMODG00000006811.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182872"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006811">
        <property type="expression patterns" value="Expressed in cerebellum and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000034">
        <property type="entry name" value="NDRG2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="384" mass="42160" checksum="7C1AB5880D482B6D" modified="2019-12-11" version="1">MSKGKLGKVLYSLSPPYVFFISPIPSQATMSELQEVSITEEKPLLPGKTLEDVKEAELAAQTLLDAGQTHSVETPFGSITFTVFGIPKPKRPAILTYHDVGLNYKTCFKPLFDTEDMQEIIKNFVRVHVEAPGMEEGAPVFPLGYQYPSLDQLADMIPFILQFLNFSTIVGFGVGAGAYVLSRYALSHPDQVEGLVLVNLDSSAKGWMDWAAHKLTGLTSSVSDMILEHLFSQEELSGSSELVQQYRNIIVHAPNLENIELFWNSFNKCPVMLVVGDQAPYEDAVVECNSKLDPTTTSFLKMADSGGQPQLTQPVKLTEALKYFLQGMGYMASSCMTRLSRSRTSSLTSNRLSRDDGRPRASSRTSDSGSIPAESPGQSMEVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7J2</accession>
    <name>A0A5F8H7J2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rhomboid-related protein 3</fullName>
            <ecNumber evidence="9">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RHBDL3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7J2"/>
    <dbReference type="Ensembl" id="ENSMODT00000071350.1">
        <property type="protein sequence ID" value="ENSMODP00000055196.1"/>
        <property type="gene ID" value="ENSMODG00000019180.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158838"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019180">
        <property type="expression patterns" value="Expressed in spinal cord and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000002">
        <property type="entry name" value="Rhomboid, veinlet-like 3 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000194">
        <property type="entry name" value="rhomboid-related protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017213">
        <property type="entry name" value="Peptidase_S54_rhomboid_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF5">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037470">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="182"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037470-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="377" mass="42446" checksum="8B31F7714CAD5B8B" modified="2019-12-11" version="1">MEGQDILERTVHLGRIPWFDPGNTGYISTGKFRSLLESHGSELDPHKREVLLALADSNSDGHICYQDFVNLMSNKRSNSFRQAILQGNRRLCSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMIAITLLEIAFFLYNGVALDQFVLQVTHPLYLKNALVYHPQLRAQAWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGAARIGFVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMECQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVAMYAVFVLFAVFWNVFAYSLLELRLPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7J3</accession>
    <name>A0A5F8H7J3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain containing 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BTBD10</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7J3"/>
    <dbReference type="Ensembl" id="ENSMODT00000056917.1">
        <property type="protein sequence ID" value="ENSMODP00000055772.1"/>
        <property type="gene ID" value="ENSMODG00000008728.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007975"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008728">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd18385">
        <property type="entry name" value="BTB_POZ_BTBD10_GMRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000017">
        <property type="entry name" value="BTB/POZ domain-containing protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039886">
        <property type="entry name" value="BTBD10/KCTD20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039885">
        <property type="entry name" value="BTBD10/KCTD20_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16017">
        <property type="entry name" value="BTB_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="135"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="443" mass="49968" checksum="F6D629E2B2028C18" modified="2019-12-11" version="1">MCTPSRVAKGGVDHTKMSLHGASGGHERSRDRRRSSDRSRDSSHERAESQLTPCIRNVTSPTRQHHIEREKDHSSSRPSSPRPQKASPNGSSSSVGNNSRNSSQSSSDGGCKTSGEMIFVYENAKEGARSIRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCVKSKSITNLAAAAADIPQDQLVVMHPTPQVDELDILPIPPPPGSNEMDPEGQSPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7J4</accession>
    <name>A0A5F8H7J4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Very low density lipoprotein receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">VLDLR</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7J4"/>
    <dbReference type="Ensembl" id="ENSMODT00000076078.1">
        <property type="protein sequence ID" value="ENSMODP00000055950.1"/>
        <property type="gene ID" value="ENSMODG00000003620.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155460"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003620">
        <property type="expression patterns" value="Expressed in heart and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000052">
        <property type="entry name" value="low-density lipoprotein receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000002">
        <property type="entry name" value="low-density lipoprotein receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000025">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000038">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000043">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000046">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000049">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000051">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000053">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000057">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000093">
        <property type="entry name" value="Very low-density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF15">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023927604" evidence="17">
        <location>
            <begin position="28"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="355"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="438"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="484"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="527"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="571"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="804" mass="88862" checksum="D9ED01BE6D98E9E0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H7J6</accession>
    <name>A0A5F8H7J6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA binding motif protein 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RBM33</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H7J6"/>
    <dbReference type="Ensembl" id="ENSMODT00000059934.1">
        <property type="protein sequence ID" value="ENSMODP00000055514.1"/>
        <property type="gene ID" value="ENSMODG00000005006.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063891"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005006">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039878">
        <property type="entry name" value="RBM33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22014">
        <property type="entry name" value="RNA-BINDING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22014:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="928"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1260" mass="141861" checksum="1F20B2A346FF9E5E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8H3</accession>
    <name>A0A5F8H8H3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8H3"/>
    <dbReference type="Ensembl" id="ENSMODT00000079882.1">
        <property type="protein sequence ID" value="ENSMODP00000055461.1"/>
        <property type="gene ID" value="ENSMODG00000014728.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164042"/>
    <dbReference type="OMA" id="VWHEGTW"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014728">
        <property type="expression patterns" value="Expressed in blood and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000012">
        <property type="entry name" value="CD163 molecule like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000031">
        <property type="entry name" value="RIKEN cDNA 5830411N06, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000002">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000004">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000009">
        <property type="entry name" value="WC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF468">
        <property type="entry name" value="SCAVENGER RECEPTOR CYSTEINE-RICH TYPE 1 PROTEIN M160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="123"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="229"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="335"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="429"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="535"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="671"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="777"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="879"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="162"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="455"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="468"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="560"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="573"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="697"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="710"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="904"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="917"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1056" mass="115558" checksum="AD070E0D522C072E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8H6</accession>
    <name>A0A5F8H8H6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spermatosis associated 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SPATA6</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPATA6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8H6"/>
    <dbReference type="Ensembl" id="ENSMODT00000070833.1">
        <property type="protein sequence ID" value="ENSMODP00000056283.1"/>
        <property type="gene ID" value="ENSMODG00000001370.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063821"/>
    <dbReference type="OMA" id="HGREFDD"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001370">
        <property type="expression patterns" value="Expressed in testis and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120212">
        <property type="term" value="C:sperm head-tail coupling apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032027">
        <property type="term" value="F:myosin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042769">
        <property type="entry name" value="SPATA6_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032732">
        <property type="entry name" value="SPATA6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16435:SF3">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16435">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 6 SPATA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14909">
        <property type="entry name" value="SPATA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 6 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="564" mass="64513" checksum="5F28F24AAB7C117E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8H8</accession>
    <name>A0A5F8H8H8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="14">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PYGL</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 14">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:41733"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer; enzymatically active. Interacts with PPP1R3B; recruits the phosphatase PP1 which dephosphorylates and inactivates PYGL/glycogen phosphorylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8H8"/>
    <dbReference type="Ensembl" id="ENSMODT00000059335.1">
        <property type="protein sequence ID" value="ENSMODP00000056280.1"/>
        <property type="gene ID" value="ENSMODG00000013150.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183148"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013150">
        <property type="expression patterns" value="Expressed in liver and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000005">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000153">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="798" mass="91740" checksum="BA321C25D98C949F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8I0</accession>
    <name>A0A5F8H8I0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphodiesterase</fullName>
            <ecNumber evidence="15">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PDE6C</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8I0"/>
    <dbReference type="Ensembl" id="ENSMODT00000060877.1">
        <property type="protein sequence ID" value="ENSMODP00000055466.1"/>
        <property type="gene ID" value="ENSMODG00000005884.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157825"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005884">
        <property type="expression patterns" value="Expressed in placenta and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000005">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000001">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000010">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0140">cGMP</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0844">Vision</keyword>
    <feature type="domain" description="PDEase" evidence="17">
        <location>
            <begin position="470"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="786"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="546"/>
            <end position="550"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="760"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="856" mass="99692" checksum="4C38A2E4096FA930" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8I3</accession>
    <name>A0A5F8H8I3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor GTPase-activating protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Zinc finger protein 289</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ARFGAP2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8I3"/>
    <dbReference type="Ensembl" id="ENSMODT00000088697.1">
        <property type="protein sequence ID" value="ENSMODP00000056285.1"/>
        <property type="gene ID" value="ENSMODG00000019901.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155568"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019901">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000004">
        <property type="entry name" value="Putative ADP-ribosylation factor GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF10">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="19">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="385" mass="42136" checksum="492CFD59DC5A3F81" modified="2019-12-11" version="1">MAAEPSKTEIQTLFKRLRAVPTNKACFDCGAKNPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELDSNWNWFQLRCMQVGGNANALGAKKGLGAQKVSSQSFSEIERQAQVAEKLREQQVAEAKKQAEESVVTSMRLAYQELQIDRKKEEKKLQSLEGQKREQAERLGMGLVSRSSVSHSVLSEMQVIEQETPVSAKSSRSQLDLFDDTGSFASGPPKYKDNPFSLGDGFASRWDTDVSWSVDRLEEKEPEVTISSIRPISERPTNRREVESRPSAVESNEARQKFAGAKAISSDMFFGREIDAEYEARSRLQQLSGSSAISSADLFGEVDGAHGAGGVSLGNVLPAADIAQFKQGVKSVAGKMAVLANGVMNSLQDRYGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8I4</accession>
    <name>A0A5F8H8I4_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1 open reading frame 94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C1orf94</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8I4"/>
    <dbReference type="Ensembl" id="ENSMODT00000068484.1">
        <property type="protein sequence ID" value="ENSMODP00000055884.1"/>
        <property type="gene ID" value="ENSMODG00000017969.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017672"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017969">
        <property type="expression patterns" value="Expressed in testis and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031496">
        <property type="entry name" value="DUF4688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35674">
        <property type="entry name" value="CDNA SEQUENCE CK137956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35674:SF1">
        <property type="entry name" value="CDNA SEQUENCE CK137956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15752">
        <property type="entry name" value="DUF4688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="581" mass="63232" checksum="AF0A2DFF843607A1" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8I5</accession>
    <name>A0A5F8H8I5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Period circadian regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PER1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8I5"/>
    <dbReference type="Ensembl" id="ENSMODT00000075887.1">
        <property type="protein sequence ID" value="ENSMODP00000056293.1"/>
        <property type="gene ID" value="ENSMODG00000007769.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159217"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007769">
        <property type="expression patterns" value="Expressed in cerebellum and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000013">
        <property type="entry name" value="Period circadian protein homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000004">
        <property type="entry name" value="Period circadian protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057310">
        <property type="entry name" value="PER1-3_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048814">
        <property type="entry name" value="Per1-3_PAS-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022728">
        <property type="entry name" value="Period_circadian-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050760">
        <property type="entry name" value="Period_circadian_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269:SF8">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23170">
        <property type="entry name" value="bHLH_PER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21353">
        <property type="entry name" value="Per3-like_PAS-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12114">
        <property type="entry name" value="Period_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="375"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="651"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="749"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="792"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="886"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="934"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1147"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="799"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1189"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1202" mass="128714" checksum="B032E8C8884EC786" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8I6</accession>
    <name>A0A5F8H8I6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP-3 complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">AP3B1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8I6"/>
    <dbReference type="Ensembl" id="ENSMODT00000065951.1">
        <property type="protein sequence ID" value="ENSMODP00000055471.1"/>
        <property type="gene ID" value="ENSMODG00000019733.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157603"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019733">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029394">
        <property type="entry name" value="AP3B1_Ser"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029390">
        <property type="entry name" value="AP3B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14796">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14797">
        <property type="entry name" value="SEEEED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01355">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP-3 complex subunit beta C-terminal" evidence="8">
        <location>
            <begin position="799"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="663"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="680"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1004" mass="112164" checksum="AC52026E61B6ADBC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8I9</accession>
    <name>A0A5F8H8I9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED23</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8I9"/>
    <dbReference type="Ensembl" id="ENSMODT00000055671.1">
        <property type="protein sequence ID" value="ENSMODP00000056298.1"/>
        <property type="gene ID" value="ENSMODG00000017578.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010380"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017578">
        <property type="expression patterns" value="Expressed in uterine wall and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11573">
        <property type="entry name" value="Med23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="476" mass="54587" checksum="C8B9F66A5EB730BC" modified="2019-12-11" version="1">METQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGSLSQESHEQCVQWIVRFIHSQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKVLTIPNTVSSAVVQQLLAAREVIAYILERNSCLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHESTLAYCFQVSCMGNFTHTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8J1</accession>
    <name>A0A5F8H8J1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Eyes absent homolog</fullName>
            <ecNumber evidence="21">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">EYA3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 21">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="20 21">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the HAD-like hydrolase superfamily. EYA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="21"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8J1"/>
    <dbReference type="Ensembl" id="ENSMODT00000074947.1">
        <property type="protein sequence ID" value="ENSMODP00000055476.1"/>
        <property type="gene ID" value="ENSMODG00000010782.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182978"/>
    <dbReference type="OMA" id="XLLSPQR"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010782">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02601">
        <property type="entry name" value="HAD_Eya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12350:FF:000002">
        <property type="entry name" value="Eyes absent homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028472">
        <property type="entry name" value="EYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006545">
        <property type="entry name" value="EYA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042577">
        <property type="entry name" value="EYA_dom_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038102">
        <property type="entry name" value="EYA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01658">
        <property type="entry name" value="EYA-cons_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190">
        <property type="entry name" value="EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190:SF5">
        <property type="entry name" value="EYES ABSENT HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 20 21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 21" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13 21" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="273"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="19">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="19">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="595" mass="65028" checksum="13696216E749DDAC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8J2</accession>
    <name>A0A5F8H8J2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="10">PARP</shortName>
            <ecNumber evidence="10">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PARP6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:54424"/>
            <dbReference type="Rhea" id="RHEA-COMP:9867"/>
            <dbReference type="Rhea" id="RHEA-COMP:13832"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + NAD(+) = S-(ADP-D-ribosyl)-L-cysteinyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56612"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:14624"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:140607"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8J2"/>
    <dbReference type="Ensembl" id="ENSMODT00000084487.1">
        <property type="protein sequence ID" value="ENSMODP00000056127.1"/>
        <property type="gene ID" value="ENSMODG00000001875.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183129"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001875">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140806">
        <property type="term" value="F:NAD+-protein-aspartate ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140803">
        <property type="term" value="F:NAD+-protein-cysteine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01341">
        <property type="entry name" value="ADP_ribosyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000032">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="11">
        <location>
            <begin position="342"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="578" mass="65281" checksum="58DAAB1600A6302E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8J3</accession>
    <name>A0A5F8H8J3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Erythrocyte membrane protein band 4.1 like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EPB41L2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000069432.1">
        <property type="protein sequence ID" value="ENSMODP00000055894.1"/>
        <property type="gene ID" value="ENSMODG00000017602.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155617"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017602">
        <property type="expression patterns" value="Expressed in spermatid and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13184">
        <property type="entry name" value="FERM_C_4_1_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000002">
        <property type="entry name" value="Erythrocyte protein band 4.1-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008379">
        <property type="entry name" value="Band_4.1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007477">
        <property type="entry name" value="SAB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF17">
        <property type="entry name" value="BAND 4.1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05902">
        <property type="entry name" value="4_1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04382">
        <property type="entry name" value="SAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="225"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="946"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="826"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="973"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1004"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1018"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1038"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1114"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1285" mass="143238" checksum="76BB2719E1341214" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8J5</accession>
    <name>A0A5F8H8J5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formin-binding protein 1-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Transducer of Cdc42-dependent actin assembly protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">FNBP1L</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FNBP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056675071.1">
        <property type="nucleotide sequence ID" value="XM_056819093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8J5"/>
    <dbReference type="Ensembl" id="ENSMODT00000086550.1">
        <property type="protein sequence ID" value="ENSMODP00000056303.1"/>
        <property type="gene ID" value="ENSMODG00000004822.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100032840"/>
    <dbReference type="CTD" id="54874"/>
    <dbReference type="GeneTree" id="ENSGT00950000183047"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004822">
        <property type="expression patterns" value="Expressed in spinal cord and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07675">
        <property type="entry name" value="F-BAR_FNBP1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11628">
        <property type="entry name" value="HR1_CIP4_FNBP1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12072">
        <property type="entry name" value="SH3_FNBP1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000002">
        <property type="entry name" value="Formin-binding protein 1-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000017">
        <property type="entry name" value="Formin-binding protein 1-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035494">
        <property type="entry name" value="FNBP1L_F-BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035493">
        <property type="entry name" value="FNBP1L_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057871">
        <property type="entry name" value="HR1_CIP4_FNBP1L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF14">
        <property type="entry name" value="FORMIN-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 19 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="23">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="24">
        <location>
            <begin position="339"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="22">
        <location>
            <begin position="480"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="418"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="130"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="547" mass="63665" checksum="9FE1093682CA653F" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8J7</accession>
    <name>A0A5F8H8J7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Alpha-(1,6)-fucosyltransferase</fullName>
            <ecNumber evidence="4 17">2.4.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">FUT8</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP-beta-L-fucose = an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12985"/>
            <dbReference type="Rhea" id="RHEA-COMP:13526"/>
            <dbReference type="Rhea" id="RHEA-COMP:13532"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:60651"/>
            <dbReference type="ChEBI" id="CHEBI:137207"/>
            <dbReference type="EC" id="2.4.1.68"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17 22">Belongs to the glycosyltransferase 23 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.68" evidence="4 17"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8J7"/>
    <dbReference type="Ensembl" id="ENSMODT00000058623.1">
        <property type="protein sequence ID" value="ENSMODP00000056132.1"/>
        <property type="gene ID" value="ENSMODG00000009731.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063737"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009731">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008424">
        <property type="term" value="F:glycoprotein 6-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11300">
        <property type="entry name" value="Fut8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11792">
        <property type="entry name" value="SH3_Fut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1060:FF:000003">
        <property type="entry name" value="Alpha-(1,6)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000070">
        <property type="entry name" value="Alpha-(1,6)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000001">
        <property type="entry name" value="Alpha-(1,6)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015827">
        <property type="entry name" value="Fut8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045573">
        <property type="entry name" value="Fut8_N_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035653">
        <property type="entry name" value="Fut8_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027350">
        <property type="entry name" value="GT23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19745">
        <property type="entry name" value="FUT8_N_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000472">
        <property type="entry name" value="Alpha1_6FUT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51659">
        <property type="entry name" value="GT23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 17 22" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="13" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GT23" evidence="24">
        <location>
            <begin position="184"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="23">
        <location>
            <begin position="480"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for donor substrate binding" evidence="18 22">
        <location>
            <begin position="343"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="SH3-binding" evidence="19">
        <location>
            <begin position="277"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="182"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="443"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000472-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000472-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000472-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="553" mass="63612" checksum="252A2B1A020C6692" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8J9</accession>
    <name>A0A5F8H8J9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">MHC class I antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MODO-UC</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the presentation of foreign antigens to the immune system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the MHC class I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8J9"/>
    <dbReference type="Ensembl" id="ENSMODT00000062108.1">
        <property type="protein sequence ID" value="ENSMODP00000055899.1"/>
        <property type="gene ID" value="ENSMODG00000038483.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271826"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000038483">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002474">
        <property type="term" value="P:antigen processing and presentation of peptide antigen via MHC class I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07698">
        <property type="entry name" value="IgC1_MHC_I_alpha3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000014">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000001">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF251">
        <property type="entry name" value="HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0490">MHC I</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023890859" evidence="12">
        <location>
            <begin position="22"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="210"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="347" mass="39280" checksum="40DBC5C0D635186D" modified="2019-12-11" version="1">MELSLLSLFMLGVVALTQTRAGSHSMRYFHTAMSRPELGDSQFITVGYVDDQQFVRFDSSSESQRMEPRAAWMDKMDEEEPNYWEEQTQIYRKNAQIYRRNLETLRGYYNQSQGGLHTIQRMIGCEVSAEGSLRKGFYQFAYDGHDYIALHTETLSWTAADTGAENTKRKWEPEKSIAESYKAYLEKECTHWLKKYLVMGKDVLLRTDPPSARVTRHRGPDGEVSLRCRAHGFYPAEISLMWLRDGEEQLQDTEFIETRPGGDGTFQKWAAVAMAPGQEDRYSCRVQHEALAQPLSLRWEPEASSLWVIVGVTAGVLVLVTAVVAGAVILRRRNSGGKGGAYVPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>F6QAE2</accession>
    <name>F6QAE2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UAP56-interacting factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Forty-two-three domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FYTTD1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UIF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_056649591.1">
        <property type="nucleotide sequence ID" value="XM_056793613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6QAE2"/>
    <dbReference type="Ensembl" id="ENSMODT00000023348.4">
        <property type="protein sequence ID" value="ENSMODP00000022942.4"/>
        <property type="gene ID" value="ENSMODG00000018393.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100021337"/>
    <dbReference type="CTD" id="84248"/>
    <dbReference type="eggNOG" id="ENOG502QWD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012807"/>
    <dbReference type="HOGENOM" id="CLU_076911_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018393">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009782">
        <property type="entry name" value="FYTTD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21038">
        <property type="entry name" value="40-2-3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21038:SF2">
        <property type="entry name" value="UAP56-INTERACTING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07078">
        <property type="entry name" value="FYTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000022942.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="297" mass="34092" checksum="F07AAFD9E573309E" modified="2019-12-11" version="3">MPRWSLFPARRFDSTNDIIKLNKKEGRKQNFPKLNRRIKHTGARQFRMRVARWGLQQQTGFGKNGLGRRGRMGPGKRRYGVITGLAARKANGVRKGISPINRPPLSEKNIQRYYPMLKRKTNLQRQNDMQRKPIPVLRRPNQLSRRNNVPVNFARSGTKLNQQKDTRQATFLFRRGLKVQAQLHPGQLLDKPTAKRTRQWRTSTTNGGILTVSIDNPGAIHPSVAQRSRLTRTPIPSFLMKRDHPEEKKIPKGVPLQFDINSVGKQTGMTLNERFGILKEQRIALTQNKGSRFVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F6RCS0</accession>
    <name>F6RCS0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM118A</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM118 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6RCS0"/>
    <dbReference type="Ensembl" id="ENSMODT00000009062.3">
        <property type="protein sequence ID" value="ENSMODP00000008887.3"/>
        <property type="gene ID" value="ENSMODG00000007167.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSNY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010215"/>
    <dbReference type="HOGENOM" id="CLU_063072_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007167">
        <property type="expression patterns" value="Expressed in spermatocyte and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038916">
        <property type="entry name" value="FAM118"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28623:SF2">
        <property type="entry name" value="PROTEIN FAM118A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28623">
        <property type="entry name" value="PROTEIN FAM118B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000008887.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="416" mass="47209" checksum="940B1AF9A6379417" modified="2019-12-11" version="3">MALTTRDGRTAAIPLTTRRWKPQAEGLQMDSAEKTTNRSEHKSRKFLKSLIRKQPHDLLLVIGTGVSAAVAPGIRALRSWRSCIEAVLEAAEQLEVLHPGDVAEFRKKVKKDRDLLVVAHDLIRKMSPDSGMLPGMPRGAVYSMERRRDLELAPSSAQERTGDTKPNFFQDCLMEVFDNLEQHIQNPTVLQSILTLMERGTMVLTTNYDNLLEIFGQQQNKPMESLDLKDKTKVLQWARGHMKYGVLHIHGLYTDPCGMVLDPSGYKDVTQDPEVMEVLQNLYRTKSFLFVGCGETLRDQIFQALFLYSVQDKVDLEHFMVVLKENEDHFFKHQADMLLHGIKVVSYGDCFDYFPEYVQDLATQICKQRSPDADRVDSTTLLGNACQDCAKRKLGEYSIDVPKRIRQSDPDDSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>F6RD25</accession>
    <name>F6RD25_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATP binding cassette subfamily C member 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ABCC9</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001362734.1">
        <property type="nucleotide sequence ID" value="XM_001362697.3"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000036084"/>
    <dbReference type="Ensembl" id="ENSMODT00000037673.3">
        <property type="protein sequence ID" value="ENSMODP00000036084.2"/>
        <property type="gene ID" value="ENSMODG00000017771.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100010456"/>
    <dbReference type="CTD" id="10060"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156680"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_0_1"/>
    <dbReference type="OMA" id="LLYALTX"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000017771">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008282">
        <property type="term" value="C:inward rectifying potassium channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008281">
        <property type="term" value="F:sulfonylurea receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061337">
        <property type="term" value="P:cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086003">
        <property type="term" value="P:cardiac muscle cell contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071318">
        <property type="term" value="P:cellular response to ATP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062197">
        <property type="term" value="P:cellular response to chemical stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035865">
        <property type="term" value="P:cellular response to potassium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060976">
        <property type="term" value="P:coronary vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019395">
        <property type="term" value="P:fatty acid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048144">
        <property type="term" value="P:fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045776">
        <property type="term" value="P:negative regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072592">
        <property type="term" value="P:oxygen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903409">
        <property type="term" value="P:reactive oxygen species biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014823">
        <property type="term" value="P:response to activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043627">
        <property type="term" value="P:response to estrogen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904880">
        <property type="term" value="P:response to hydrogen sulfide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901652">
        <property type="term" value="P:response to peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042311">
        <property type="term" value="P:vasodilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18591">
        <property type="entry name" value="ABC_6TM_SUR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18602">
        <property type="entry name" value="ABC_6TM_SUR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03290">
        <property type="entry name" value="ABCC_SUR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03288">
        <property type="entry name" value="ABCC_SUR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000005">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000197">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000394">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000388">
        <property type="entry name" value="ABCC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001475">
        <property type="entry name" value="ABCC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047080">
        <property type="entry name" value="ABCC9_ATP-bd_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF173">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01094">
        <property type="entry name" value="SULFNYLUR2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01092">
        <property type="entry name" value="SULFNYLUREAR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="982"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1034"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1127"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1225"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="306"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="672"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="995"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1315"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="944"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="951"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000036084.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1552" mass="174972" checksum="46473DB868A4ED4D" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F6TJ75</accession>
    <name>F6TJ75_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Methyl-CpG-binding protein 2</fullName>
            <shortName evidence="12">MeCp-2 protein</shortName>
            <shortName evidence="12">MeCp2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MECP2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FNBP3. Interacts with CDKL5. Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells. Interacts with NCOR2. Interacts with TBL1XR1; bridges interaction between MECP2 and NCOR1. Interacts with TBL1X; recruits TBL1X to the heterochromatin foci.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <text evidence="12">Colocalized with methyl-CpG in the genome.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6TJ75"/>
    <dbReference type="Ensembl" id="ENSMODT00000014853.4">
        <property type="protein sequence ID" value="ENSMODP00000014585.4"/>
        <property type="gene ID" value="ENSMODG00000011643.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063687"/>
    <dbReference type="HOGENOM" id="CLU_045066_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011643">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F6TJ75">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010385">
        <property type="term" value="F:double-stranded methylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000026">
        <property type="term" value="P:regulation of multicellular organismal development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01396">
        <property type="entry name" value="MeCP2_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.890.10:FF:000004">
        <property type="entry name" value="Methyl-CpG-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017353">
        <property type="entry name" value="Me_CpG-bd_MeCP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF6">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038006">
        <property type="entry name" value="Methyl_CpG_bd_MeCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MBD" evidence="14">
        <location>
            <begin position="99"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="156"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="326"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000014585.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="509" mass="54907" checksum="FDC24EFE3AEE4463" modified="2019-12-11" version="2">MAAAAALSGGGGGEEDRLEEQSEDQDLQGLRDKPLKFRKLKRDKKEEKEGKHEFPQPSSHQSAEPAEAGKAETSEEAGSAPAAPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKSKSPKAPGTGRGRGRPKGSGTVKPRVTASEGVQVKRVIEKSPGKLLVKMPFQPSPGGKAEGGGATTSTQVMVIKRPGRKRKVETEPQVIPKKRGRKPGSIVAAAAVEAKKKAIKESSIRSIHETVLPIKKRKTREAVSIEVKEVVKPLLVSTVGEKSTKGLKPGKSPGRKSKESSPKGRSASTSSSPPKKEQQQQQQYHHHHYYPSSESPKAPPPPHPEPEGSKDSKSPPEPQDLSSKVCKEEKMPRGAPPESDGCTKELAKTQPTAAAASAAATAATATTATTAAEKFKHRAEGDRKDIVSSSMPRPNREDPVDSRTPVTERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>F6UMQ1</accession>
    <name>F6UMQ1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sodium-coupled monocarboxylate transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC103101763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007503541.2">
        <property type="nucleotide sequence ID" value="XM_007503479.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6UMQ1"/>
    <dbReference type="Ensembl" id="ENSMODT00000006063.4">
        <property type="protein sequence ID" value="ENSMODP00000005939.3"/>
        <property type="gene ID" value="ENSMODG00000004821.4"/>
    </dbReference>
    <dbReference type="GeneID" id="103101763"/>
    <dbReference type="KEGG" id="mdo:103101763"/>
    <dbReference type="eggNOG" id="KOG2349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155166"/>
    <dbReference type="HOGENOM" id="CLU_018808_11_1_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004821">
        <property type="expression patterns" value="Expressed in spermatocyte and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF10">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000005939.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="574" mass="63519" checksum="5E5C6DB455654304" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>F6VPU0</accession>
    <name>F6VPU0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-serine deaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6VPU0"/>
    <dbReference type="Ensembl" id="ENSMODT00000038409.3">
        <property type="protein sequence ID" value="ENSMODP00000036813.2"/>
        <property type="gene ID" value="ENSMODG00000025082.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00600000084626"/>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000025082">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF19">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="228"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000036813.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="440" mass="49322" checksum="692BC84E66AF7FE1" modified="2019-12-11" version="2">MCWRSAGSLGGFSKGQGLVLSGEDRKAFRTMNFVARLLYLKEPLDRTSGAPFGGEEDYDLFWPSYAEELISRRNNDKEKKPEAATHQDTYGKEQEPLENSSLGRCQPPNQLEQLKDYGEENGLQGSSKTWEIKVREHRVELLNDSPSPVGPSKGRTHRQPSSSKLIRLEDINRAAIQIQRGVQITPCTYSRLSKKYGMELYMKKEYLQYTGSVKDRGVLCLLASLHQGVQPESFPVLQHSLRMGQPIDGGSHMFYRDLSEPCSGKNTLQLVGQLVDKIVSVTEEDILIAMLRLLEYERATVDAEGAIGLAAIVAGKLPEFKGKRVAVALCSGNLSLNLLQQCIQRALTLDSRICKFSLWMGDGTGDISKLLEILDREAVRVLDIQKEHGFVTSKLFTTKVTCVAETRDKQQATQLRSALLERYPTLEWLLQIHVREGLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>F6VQ66</accession>
    <name>F6VQ66_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Spi-1 proto-onco</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SPI1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007497477.1">
        <property type="nucleotide sequence ID" value="XM_007497415.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6VQ66"/>
    <dbReference type="Ensembl" id="ENSMODT00000025278.4">
        <property type="protein sequence ID" value="ENSMODP00000024837.4"/>
        <property type="gene ID" value="ENSMODG00000019909.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100016353"/>
    <dbReference type="CTD" id="6688"/>
    <dbReference type="eggNOG" id="KOG3805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159754"/>
    <dbReference type="HOGENOM" id="CLU_066451_0_0_1"/>
    <dbReference type="OMA" id="SYLPRMY"/>
    <dbReference type="OrthoDB" id="10043646at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019909">
        <property type="expression patterns" value="Expressed in blood and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000250">
        <property type="entry name" value="transcription factor Spi-B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR PU.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ETS" evidence="9">
        <location>
            <begin position="200"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000024837.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="300" mass="34338" checksum="BE46F0B21D8242E3" modified="2019-12-11" version="3">MPRGSGVGPAEPGELTGPEIGWMLQACKMEGFPLVSPPSEDMVPYDTDLYRQTHEYYPYIGSDGESHSDHYWDFHPHHMHNEFENFPENHFTELQSVQPPQLQQLYRHMELEQMHVLDTPMTTAHGSISHQVPSLAPLHSSQVSYMPCMCLQYTSPTQPSSDEEEGERQSPPLEVSDGETEVLEPGPGMLHGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGTLVDRRHQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>F6W1U0</accession>
    <name>F6W1U0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Granzyme B(G,H)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC100015759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_001369757.1">
        <property type="nucleotide sequence ID" value="XM_001369720.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F6W1U0"/>
    <dbReference type="MEROPS" id="S01.465"/>
    <dbReference type="Ensembl" id="ENSMODT00000002371.4">
        <property type="protein sequence ID" value="ENSMODP00000002323.3"/>
        <property type="gene ID" value="ENSMODG00000001902.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100015759"/>
    <dbReference type="KEGG" id="mdo:100015759"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234551"/>
    <dbReference type="HOGENOM" id="CLU_006842_1_0_1"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001902">
        <property type="expression patterns" value="Expressed in blood"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000014">
        <property type="entry name" value="Complement factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000005">
        <property type="entry name" value="Serine protease 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF81">
        <property type="entry name" value="GRANZYME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003349233" evidence="8">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000002323.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="252" mass="28412" checksum="4B77C409C7CC1827" modified="2013-01-09" version="2">MHFLVPVLLIFLQSSDSRAGEIIGGREAKPHSRPYMAYLKYSNKNGKSGICGGFLVQKKFLLTAAHCWGSSISVLLGAHNIKKPEKTQQQIPVLRAIRHKEYNNKNFNNDIMLLQLKKMARLNQDVGLLALPQKAVKVKPNQTCIVAGWGCTLKRLFSDTLQEVKLKVRRDYECKEKYRNHYNHSTQMCVGDPNVQKASFQGDSGGPLVCDGIAQGIVSYGFQNGSSPRVFTRISSFLPWIKRTMKTLEDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>F6WSX8</accession>
    <name>F6WSX8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Integrin subunit alpha L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ITGAL</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6WSX8"/>
    <dbReference type="Ensembl" id="ENSMODT00000037733.3">
        <property type="protein sequence ID" value="ENSMODP00000036144.2"/>
        <property type="gene ID" value="ENSMODG00000001568.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161495"/>
    <dbReference type="HOGENOM" id="CLU_004111_3_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001568">
        <property type="expression patterns" value="Expressed in blood and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF84">
        <property type="entry name" value="INTEGRIN ALPHA-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0401">Integrin</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="984"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="123"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="418"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="479"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="539"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1027"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000036144.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118950" checksum="861CAA77FCD05953" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F6X4B4</accession>
    <name>F6X4B4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Mitotic checkpoint serine/threonine-protein kinase BUB1 beta</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">MAD3/BUB1-related protein kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Mitotic checkpoint kinase MAD3L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">BUB1B</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="F6X4B4"/>
    <dbReference type="FunCoup" id="F6X4B4">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000000684"/>
    <dbReference type="Ensembl" id="ENSMODT00000000699.4">
        <property type="protein sequence ID" value="ENSMODP00000000684.3"/>
        <property type="gene ID" value="ENSMODG00000000568.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100031856"/>
    <dbReference type="CTD" id="701"/>
    <dbReference type="eggNOG" id="KOG1166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158912"/>
    <dbReference type="HOGENOM" id="CLU_010890_0_0_1"/>
    <dbReference type="InParanoid" id="F6X4B4"/>
    <dbReference type="OMA" id="KTLCPNP"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000568">
        <property type="expression patterns" value="Expressed in hindlimb bud and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000940">
        <property type="term" value="C:outer kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071459">
        <property type="term" value="P:protein localization to chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000494">
        <property type="entry name" value="mitotic checkpoint serine/threonine-protein kinase BUB1 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000002">
        <property type="entry name" value="mitotic checkpoint serine/threonine-protein kinase BUB1 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF25">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="21" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="13" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="28">
        <location>
            <begin position="49"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="439"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00074450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00080874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00083762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000000684.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1070" mass="121572" checksum="307AFE3E67324DE2" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>F6YYG1</accession>
    <name>F6YYG1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TRAF3-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Intraflagellar transport protein 54 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Microtubule-interacting protein associated with TRAF3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TRAF3IP1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAF3IP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="F6YYG1"/>
    <dbReference type="Ensembl" id="ENSMODT00000030059.3">
        <property type="protein sequence ID" value="ENSMODP00000028477.2"/>
        <property type="gene ID" value="ENSMODG00000002477.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100009843"/>
    <dbReference type="KEGG" id="mdo:100009843"/>
    <dbReference type="CTD" id="26146"/>
    <dbReference type="eggNOG" id="KOG3809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00720000108822"/>
    <dbReference type="HOGENOM" id="CLU_023216_0_0_1"/>
    <dbReference type="OMA" id="FRFLMDV"/>
    <dbReference type="OrthoDB" id="10258914at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002477">
        <property type="expression patterns" value="Expressed in testis and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001738">
        <property type="term" value="P:morphogenesis of a polarized epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050687">
        <property type="term" value="P:negative regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.50:FF:000001">
        <property type="entry name" value="TRAF3-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.50">
        <property type="entry name" value="Microtubule-binding protein MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018799">
        <property type="entry name" value="TRAF3IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041476">
        <property type="entry name" value="TRAF3IP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040468">
        <property type="entry name" value="TRAF3IP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042576">
        <property type="entry name" value="TRAF3IP1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363:SF0">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10243">
        <property type="entry name" value="MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17749">
        <property type="entry name" value="MIP-T3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAF3-interacting protein 1 N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF3-interacting protein 1 C-terminal" evidence="14">
        <location>
            <begin position="555"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="136"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="147"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000028477.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="715" mass="81870" checksum="299E9177213C7FB9" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F7BQ63</accession>
    <name>F7BQ63_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Endonuclease 8-like 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">DNA glycosylase/AP lyase Neil1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">DNA-(apurinic or apyrimidinic site) lyase Neil1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Endonuclease VIII-like 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Nei homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Nei-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">NEIL1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_001379906.2">
        <property type="nucleotide sequence ID" value="XM_001379869.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F7BQ63"/>
    <dbReference type="Ensembl" id="ENSMODT00000011443.4">
        <property type="protein sequence ID" value="ENSMODP00000011226.4"/>
        <property type="gene ID" value="ENSMODG00000009002.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100030381"/>
    <dbReference type="KEGG" id="mdo:100030381"/>
    <dbReference type="CTD" id="79661"/>
    <dbReference type="eggNOG" id="ENOG502QSPK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153230"/>
    <dbReference type="HOGENOM" id="CLU_051284_0_0_1"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009002">
        <property type="expression patterns" value="Expressed in liver and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000007">
        <property type="entry name" value="endonuclease 8-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.190.10:FF:000003">
        <property type="entry name" value="endonuclease 8-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015371">
        <property type="entry name" value="Endonuclease-VIII_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF27">
        <property type="entry name" value="ENDONUCLEASE 8-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09292">
        <property type="entry name" value="Neil1-DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="23">
        <location>
            <begin position="32"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="309"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00083344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011226.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="450" mass="50012" checksum="05FC424795C19B4E" modified="2019-12-11" version="3">MITGKLIIQIKRKLGNGEGQHGNTLSPASRMPEGPELYLASCYVNSMCKDLVFAGPVEKSEVSRNPEVPFESSAYRISATSRGKEVRLTLSPLPKAHPPQEPLDLVFRFGMSGSFQLVPADALPKHAHLRFYTISPAPRQALCFVDVRRFGHWEVQGTWQPGRGPCVLQEYEKFRENVLQNLANKTFDKPICEALLEQRFFNGIGNYLRAEILYRLKIPPFEKARTVLEALKHRRQDPELTLSKKIKAKLENPDLLELCHSVPMEVIQLGGKGYGPDREEDDFAAFRAWLRCYSVPGMSSLQDRHGRTIWFQGDPGPLAPKGRTSRKKRVKEKSNPEVTDLEDSVPVPKKKGPNRARKPGKKKPQKESEPEAKGKVGSTRGPKSKPQLKASAPTSPGDKPGVLEGKQRPMIRKRTGSTRKRKANSKASGSPSSFLPLSQKGDVALGSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F7C1S9</accession>
    <name>F7C1S9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 91</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC91</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="F7C1S9"/>
    <dbReference type="Ensembl" id="ENSMODT00000018349.4">
        <property type="protein sequence ID" value="ENSMODP00000018017.4"/>
        <property type="gene ID" value="ENSMODG00000014414.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QW5U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015899"/>
    <dbReference type="HOGENOM" id="CLU_050535_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014414">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034592">
        <property type="entry name" value="CCDC91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35072">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35072:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000018017.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="427" mass="48086" checksum="DA61692546535888" modified="2019-12-11" version="3">MDDDDFGGFEAAETFDGGNGETHTTSPAIPWAAFPTVSGVHITPPVSPESILEQPLSSAHLISSKPIISSQNNALIVPQTGNNIVSHALSKDQVQQSTNTVDPSVSPLNLTDKKNNETVKLVDAAAEDHKAIGLNMDLREKIASLEVKLKTSEEEKQKIKKDLEMLLEKHRILEKDFLKDKEDEALSHQDRYKMLQEKHKHQLEDMRKAGHETLTIITEEYKALLQTTVQQQADSIEKQYISAIEKQACKCGELLNAQEILGKCLAEEMQRNKDALTTAAKIEKATMKDAILKAVEEERKKLGKVHAEERDLWKAEHDKDQEKVAQAIQEALQEQRKISQEILKEAMAEEQKRSEKAVEEAVRKTREELIEYVKEQKRLDQVIRQRSLSTLELFLSCAQKQLSSLISEEPASTEDGEHDKLASTDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>F7C256</accession>
    <name>F7C256_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">MacroH2A.1 histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MACROH2A1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7C256"/>
    <dbReference type="Ensembl" id="ENSMODT00000018334.4">
        <property type="protein sequence ID" value="ENSMODP00000018003.4"/>
        <property type="gene ID" value="ENSMODG00000014397.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159541"/>
    <dbReference type="HOGENOM" id="CLU_062828_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014397">
        <property type="expression patterns" value="Expressed in hindlimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02904">
        <property type="entry name" value="Macro_H2A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000013">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000002">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021171">
        <property type="entry name" value="Core_histone_macro-H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035796">
        <property type="entry name" value="Macro_H2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037942">
        <property type="entry name" value="Core_histone_macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="13">
        <location>
            <begin position="219"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="163"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate" evidence="10">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="10">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037942-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000018003.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="404" mass="43240" checksum="3F222BAFAE1DB840" modified="2019-12-11" version="3">MHVCPILDELRIGMGDLIAFSFAFVVCCFTSRKNKMSSRGGKKKSTKTSRSAKAGVIFPVGRMLRYIKKGHPKYRIGVGAPVYMAAVLEYLTAEILELAGNAARDNKKGRVTPRHILLAVANDEELNQLLKGVTIASGGVLPNIHPELLAKKRGSKGKLEAIITPPPAKKAKSPSQKKPVSKKAGGKKGPRKSKKKQGEVSKAASADSTTEGTPADGFTVLSTKSLFLGQKLQVVQADIATIDSDAVVHPTNSDFYIGGEVGNTLEKKGGKEFVEAVLELRKKNGPLDIAGAAVSAGHGLPAKFVIHCNSPIWGSDKCEELLEKTVKNCLALADDRKLKSIAFPSIGSGRNGFPKQTAAQLILRAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEMAKLDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F7C262</accession>
    <name>F7C262_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="26">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">FAR2</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>18-methylnonadecanoyl-CoA + 2 NADPH + 2 H(+) = 18-methylnonadecan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81767"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:84914"/>
            <dbReference type="ChEBI" id="CHEBI:231999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:81768"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>20-methylheneicosanoyl-CoA + 2 NADPH + 2 H(+) = 20-methylheneicosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81771"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:84915"/>
            <dbReference type="ChEBI" id="CHEBI:232000"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:81772"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>22-methyltricosanoyl-CoA + 2 NADPH + 2 H(+) = 22-methyltricosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:84916"/>
            <dbReference type="ChEBI" id="CHEBI:232001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:81776"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>24-methylpentacosanoyl-CoA + 2 NADPH + 2 H(+) = 24-methylpentacosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81779"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:84917"/>
            <dbReference type="ChEBI" id="CHEBI:232002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:81780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a very long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a very long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81751"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:138741"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:81752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an ultra-long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = an ultra long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81755"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:143016"/>
            <dbReference type="ChEBI" id="CHEBI:143018"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:81756"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>docosanoyl-CoA + 2 NADPH + 2 H(+) = docosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31000"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65059"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:81732"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>eicosanoyl-CoA + 2 NADPH + 2 H(+) = eicosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:75627"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81728"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexacosanoyl-CoA + 2 NADPH + 2 H(+) = hexacosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28415"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:64868"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:81740"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoyl-CoA + 2 NADPH + 2 H(+) = hexadecan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:36315"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16125"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:36316"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>octacosanoyl-CoA + 2 NADPH + 2 H(+) = octacosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28243"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:74141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:81744"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>octadecanoyl-CoA + 2 NADPH + 2 H(+) = octadecan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:36319"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32154"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>tetracosanoyl-CoA + 2 NADPH + 2 H(+) = tetracosan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:77413"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:81736"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>triacontanoyl-CoA + 2 NADPH + 2 H(+) = triacontan-1-ol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:81747"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28409"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:76386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:81748"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 26">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="26"/>
    <dbReference type="AlphaFoldDB" id="F7C262"/>
    <dbReference type="Ensembl" id="ENSMODT00000018333.3">
        <property type="protein sequence ID" value="ENSMODP00000018002.2"/>
        <property type="gene ID" value="ENSMODG00000014398.3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006367"/>
    <dbReference type="HOGENOM" id="CLU_024661_0_2_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014398">
        <property type="expression patterns" value="Expressed in uterine wall and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010025">
        <property type="term" value="P:wax biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000278">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF120">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 26" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 26" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 26" id="KW-0521">NADP</keyword>
    <keyword evidence="7 26" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="28">
        <location>
            <begin position="15"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="27">
        <location>
            <begin position="357"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000018002.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="464" mass="52782" checksum="5E7C967329EA2BAD" modified="2019-12-11" version="2">MSAIAAYYGGKSILITGATGFMGKVLVEKLFRTSPDLKVIYILVRPKAGQSLQQRVSQMINCKLFEKAKEICPNIFEKIRPIYADLTKPDLGISKEDLEELLDHTNIIFHCAATVRFDDSLRHALQLNVIATQQLLLMASQMPKLEVFIHFSTAYANCNLKHIDEVIYPCSVEPKKLIDSVEWLDDSIIEEITPKLIENRPNTYTYTKALGEMVVYQESGNLNIAIIRPSIVGASWQEPFPGWVDNLNGPSGLIIATGKGFLRAIKATPRAVADVVPVDLVINLTLAVGWHTAVHRPKSILIYHCTSGSLNPCSWIDLGFQVLATFEKAPLEKAFRRPKADFTTNSFSTYLWNTISHMAPAVIYDFYLRLTGRKPRMAKLMNRMLKTISMLEYFINHSWEWSTYNTEMLMSQLSNEDQKLFNFDVRHLNWLEYTENYCIGVKKYLLKEDMAGIPAAKKHLRICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>F7D4A1</accession>
    <name>F7D4A1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras GTPase-activating protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ras p21 protein activator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">p120GAP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">RASA1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with SQSTM1. Interacts with SPSB1; the interaction does not promote degradation. Interacts with CAV2 (tyrosine phosphorylated form). Directly interacts with NCK1. Interacts with PDGFRB (tyrosine phosphorylated). Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1. Interacts with tyrosine-phosphorylated EPHB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="F7D4A1"/>
    <dbReference type="Ensembl" id="ENSMODT00000025764.4">
        <property type="protein sequence ID" value="ENSMODP00000025314.3"/>
        <property type="gene ID" value="ENSMODG00000020235.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155846"/>
    <dbReference type="HOGENOM" id="CLU_010968_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020235">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08400">
        <property type="entry name" value="C2_Ras_p21A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13260">
        <property type="entry name" value="PH_RASA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05391">
        <property type="entry name" value="RasGAP_p120GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10354">
        <property type="entry name" value="SH2_Cterm_RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10353">
        <property type="entry name" value="SH2_Nterm_RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11788">
        <property type="entry name" value="SH3_RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000007">
        <property type="entry name" value="RAS p21 protein activator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000090">
        <property type="entry name" value="RAS p21 protein activator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000050">
        <property type="entry name" value="RAS p21 protein activator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000052">
        <property type="entry name" value="RAS p21 protein activator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000033">
        <property type="entry name" value="RAS p21 protein activator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000046">
        <property type="entry name" value="RAS p21 protein activator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035842">
        <property type="entry name" value="RasGAP_C_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035841">
        <property type="entry name" value="RasGAP_N_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035652">
        <property type="entry name" value="RasGAP_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF146">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 14" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="156"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="254"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="326"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="18">
        <location>
            <begin position="449"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="557"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="20">
        <location>
            <begin position="723"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="73"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="988"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="988"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000025314.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1010" mass="113020" checksum="047248323F3C0C66" modified="2013-01-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F7DVD1</accession>
    <name>F7DVD1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aromatic-L-amino-acid decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DOPA decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DDC</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.28" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="F7DVD1"/>
    <dbReference type="FunCoup" id="F7DVD1">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000011560"/>
    <dbReference type="Ensembl" id="ENSMODT00000011780.3">
        <property type="protein sequence ID" value="ENSMODP00000011560.2"/>
        <property type="gene ID" value="ENSMODG00000009255.4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156004"/>
    <dbReference type="HOGENOM" id="CLU_011856_3_0_1"/>
    <dbReference type="InParanoid" id="F7DVD1"/>
    <dbReference type="OMA" id="NPGFNWS"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009255">
        <property type="expression patterns" value="Expressed in kidney and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036467">
        <property type="term" value="F:5-hydroxy-L-tryptophan decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036468">
        <property type="term" value="F:L-dopa decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042416">
        <property type="term" value="P:dopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000018">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF167">
        <property type="entry name" value="AROMATIC-L-AMINO-ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0127">Catecholamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000011560.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="515" mass="58088" checksum="17CBAAED6D34FE73" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>F7DVE8</accession>
    <name>F7DVE8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylinositol 4-kinase beta</fullName>
            <ecNumber evidence="5">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PI4KB</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19878"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6. Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding. Interacts with ACBD3. Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN. Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane. Interacts with ATG9A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion outer membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Rough endoplasmic reticulum membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="F7DVE8"/>
    <dbReference type="FunCoup" id="F7DVE8">
        <property type="interactions" value="2910"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000023537"/>
    <dbReference type="Ensembl" id="ENSMODT00000023955.4">
        <property type="protein sequence ID" value="ENSMODP00000023537.3"/>
        <property type="gene ID" value="ENSMODG00000018862.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074892"/>
    <dbReference type="InParanoid" id="F7DVE8"/>
    <dbReference type="OMA" id="HKLANCN"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018862">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F7DVE8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048839">
        <property type="term" value="P:inner ear development"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22246">
        <property type="entry name" value="PI4KB_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000031">
        <property type="entry name" value="Phosphatidylinositol 4-kinase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000004">
        <property type="entry name" value="Phosphatidylinositol 4-kinase, catalytic, beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="21">
        <location>
            <begin position="49"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="20">
        <location>
            <begin position="532"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="245"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000023537.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="834" mass="93246" checksum="EF0F987B877D7D12" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-01-09" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>I6MS70</accession>
    <name>I6MS70_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Early lactation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ELP</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="BMC Evol. Biol." volume="12" first="80" last="80">
            <title>The mammary gland-specific marsupial ELP and eutherian CTI share a common ancestral gene.</title>
            <authorList>
                <person name="Pharo E.A."/>
                <person name="De Leo A.A."/>
                <person name="Renfree M.B."/>
                <person name="Thomson P.C."/>
                <person name="Lefevre C.M."/>
                <person name="Nicholas K.R."/>
            </authorList>
            <dbReference type="PubMed" id="22681678"/>
            <dbReference type="DOI" id="10.1186/1471-2148-12-80"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="4">Early lactation mammary gland</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2016" name="Gene" volume="578" first="7" last="16">
            <title>A colostrum trypsin inhibitor gene expressed in the Cape fur seal mammary gland during lactation.</title>
            <authorList>
                <person name="Pharo E.A."/>
                <person name="Cane K.N."/>
                <person name="McCoey J."/>
                <person name="Buckle A.M."/>
                <person name="Oosthuizen W.H."/>
                <person name="Guinet C."/>
                <person name="Arnould J.P."/>
            </authorList>
            <dbReference type="PubMed" id="26639991"/>
            <dbReference type="DOI" id="10.1016/j.gene.2015.11.042"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="JN191340">
        <property type="protein sequence ID" value="AEN62468.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK008086">
        <property type="protein sequence ID" value="DAA35189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I6MS70"/>
    <dbReference type="Ensembl" id="ENSMODT00000053079.1">
        <property type="protein sequence ID" value="ENSMODP00000045228.1"/>
        <property type="gene ID" value="ENSMODG00000023237.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164331"/>
    <dbReference type="HOGENOM" id="CLU_1377711_0_0_1"/>
    <dbReference type="OMA" id="TSSECEH"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000023237">
        <property type="expression patterns" value="Expressed in placenta and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="I6MS70">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000081">
        <property type="entry name" value="Serine proteinase inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF380">
        <property type="entry name" value="COLOSTRUM TRYPSIN INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010125015" evidence="2">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEN62468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="DAA35189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000045228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="96" mass="10581" checksum="9B4D1F2EF4B84277" modified="2013-01-09" version="1">MKFTIVALCFALGLAGITSSEEVLEQNPLNTQENPVPLVLPLCLLPPERGNCDSLNLRYFYNSTSRLCEAFIYSGCNGNGNNFDTVECCLKTCRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5A3</accession>
    <name>A0A5F8G5A3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">AP3D1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5A3"/>
    <dbReference type="Ensembl" id="ENSMODT00000080820.1">
        <property type="protein sequence ID" value="ENSMODP00000042673.1"/>
        <property type="gene ID" value="ENSMODG00000004631.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075067"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004631">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000055">
        <property type="entry name" value="AP-3 complex subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000001">
        <property type="entry name" value="AP-3 complex subunit delta-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010474">
        <property type="entry name" value="AP3D_dom_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058898">
        <property type="entry name" value="Mu_AP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06375">
        <property type="entry name" value="AP3D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26171">
        <property type="entry name" value="Mu_AP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01354">
        <property type="entry name" value="BLVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP-3 complex subunit delta" evidence="16">
        <location>
            <begin position="660"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="622"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="724"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="725"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="741"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="795"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="841"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="855"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="879"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="925"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1110" mass="126258" checksum="875502BF2ABEC62B" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5A5</accession>
    <name>A0A5F8G5A5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COMM domain containing 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">COMMD10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5A5"/>
    <dbReference type="Ensembl" id="ENSMODT00000080543.1">
        <property type="protein sequence ID" value="ENSMODP00000042678.1"/>
        <property type="gene ID" value="ENSMODG00000013618.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100029172"/>
    <dbReference type="KEGG" id="mdo:100029172"/>
    <dbReference type="CTD" id="51397"/>
    <dbReference type="GeneTree" id="ENSGT00390000001500"/>
    <dbReference type="OrthoDB" id="77522at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013618">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 22 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd04758">
        <property type="entry name" value="Commd10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037361">
        <property type="entry name" value="COMMD10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12333">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12333:SF0">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="135"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="216" mass="24440" checksum="41F5A3B37260F9DD" modified="2019-12-11" version="1">MASPAGTQLILPETPSMKKAVSLVNAVDTGRFPRLLTRILQKLHLKTENSFSEEEEEKLQVAFSLEKQDLHLVLETISFILEQAVYHNAKPVVLQQQLENVHLSQDKAEAFANAWASMGQETVEKFRQRILAPQKLETIGWKLNLQMAQSNQAKLKSPQAVLELGVSNEDSKDKKCQLLYSWTPRSLHMVTEAKTSAMTTLDGIRKNRYITLLTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5A6</accession>
    <name>A0A5F8G5A6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5A6"/>
    <dbReference type="Ensembl" id="ENSMODT00000070455.1">
        <property type="protein sequence ID" value="ENSMODP00000042596.1"/>
        <property type="gene ID" value="ENSMODG00000007988.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014165"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007988">
        <property type="expression patterns" value="Expressed in forelimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="154" mass="18187" checksum="4EB9135BD73F26C3" modified="2019-12-11" version="1">MGSGRGRVKMKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKEETIEKMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5A7</accession>
    <name>A0A5F8G5A7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Bromodomain and WD repeat-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">WD repeat-containing protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BRWD1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">May be a transcriptional activator. May be involved in chromatin remodeling. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with SMARCA4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000053512.1">
        <property type="protein sequence ID" value="ENSMODP00000042609.1"/>
        <property type="gene ID" value="ENSMODG00000020973.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183107"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020973">
        <property type="expression patterns" value="Expressed in forelimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05529">
        <property type="entry name" value="Bromo_WDR9_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000017">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000023">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000071">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1040:FF:000003">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000008">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052060">
        <property type="entry name" value="Bromo_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057451">
        <property type="entry name" value="BRWD/PHIP_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057452">
        <property type="entry name" value="BRWD/PHIP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266:SF26">
        <property type="entry name" value="BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266">
        <property type="entry name" value="WD REPEAT DOMAIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25437">
        <property type="entry name" value="BRWD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25313">
        <property type="entry name" value="BRWD_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="10 20" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 21" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="464"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="23">
        <location>
            <begin position="1107"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="23">
        <location>
            <begin position="1249"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="836"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00080864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1385" mass="159578" checksum="671EEC1E7D7E4F48" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5A9</accession>
    <name>A0A5F8G5A9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cathepsin L1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC100013197</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5A9"/>
    <dbReference type="FunCoup" id="A0A5F8G5A9">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMODT00000062706.1">
        <property type="protein sequence ID" value="ENSMODP00000042642.1"/>
        <property type="gene ID" value="ENSMODG00000002844.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153321"/>
    <dbReference type="InParanoid" id="A0A5F8G5A9"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002844">
        <property type="expression patterns" value="Expressed in placenta and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000332">
        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023884081" evidence="9">
        <location>
            <begin position="18"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="11">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="10">
        <location>
            <begin position="117"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="346" mass="38531" checksum="2F1256B7B808CB85" modified="2019-12-11" version="1">MNFYLCLASLCLGLAAAILPFDRALDSQWHQWKAQHGKSYEANEDSLRRAIWEKNLKMIERHNQEYRAGKQSFQLGMNKFGDMTTEEFKQVMNGYNSNGSQKRTKGSLYREPLLAQLPKSVDWREKGYVTPVKNQGQCGSCWAFSATGSLEGQWFHKTKKLVSLSEQNLVDCSTSEGNNGCSGGLMDNAFEYVKNNGGIDTEQAYPYLGQDNECKYRAECSGANVTGFVDIPSMNERALMKAVANVGPISVAIDAGNPSFQFYESGVYYEPQCSSSQLDHGVLVVGYGSIGKDEYWIVKNSWGEEWGKKGYVLMAKFRNNHCGIATAASYPQVNVAQDPSYNLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5B3</accession>
    <name>A0A5F8G5B3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Desmocollin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DSC2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5B3"/>
    <dbReference type="Ensembl" id="ENSMODT00000077775.1">
        <property type="protein sequence ID" value="ENSMODP00000042614.1"/>
        <property type="gene ID" value="ENSMODG00000011103.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234624"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011103">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000011">
        <property type="entry name" value="Cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000019">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000027">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000031">
        <property type="entry name" value="Cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000091">
        <property type="entry name" value="Desmocollin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000005">
        <property type="entry name" value="Desmocollin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014868">
        <property type="entry name" value="Cadherin_pro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009122">
        <property type="entry name" value="Desmosomal_cadherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF0">
        <property type="entry name" value="DESMOCOLLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01818">
        <property type="entry name" value="DESMOCADHERN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01820">
        <property type="entry name" value="DESMOCOLLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01055">
        <property type="entry name" value="Cadherin_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 14" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="85"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="193"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="305"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="422"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="846" mass="94353" checksum="50333FF403C98CEC" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5B5</accession>
    <name>A0A5F8G5B5_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein disulfide-isomerase TMX3</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Thioredoxin domain-containing protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Thioredoxin-related transmembrane protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TMX3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5B5"/>
    <dbReference type="FunCoup" id="A0A5F8G5B5">
        <property type="interactions" value="2562"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042606"/>
    <dbReference type="Ensembl" id="ENSMODT00000060230.1">
        <property type="protein sequence ID" value="ENSMODP00000042606.1"/>
        <property type="gene ID" value="ENSMODG00000021402.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151022"/>
    <dbReference type="InParanoid" id="A0A5F8G5B5"/>
    <dbReference type="OMA" id="GIEMRNM"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021402">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03000">
        <property type="entry name" value="PDI_a_TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000115">
        <property type="entry name" value="protein disulfide-isomerase TMX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000121">
        <property type="entry name" value="protein disulfide-isomerase TMX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="20">
        <location>
            <begin position="103"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="500"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="542" mass="63184" checksum="45F3491D02163689" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5B7</accession>
    <name>A0A5F8G5B7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MICAL like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MICALL2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5B7"/>
    <dbReference type="Ensembl" id="ENSMODT00000059798.1">
        <property type="protein sequence ID" value="ENSMODP00000042652.1"/>
        <property type="gene ID" value="ENSMODG00000008843.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160222"/>
    <dbReference type="OMA" id="DWFQLIH"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008843">
        <property type="expression patterns" value="Expressed in spermatid and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09444">
        <property type="entry name" value="LIM_Mical_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022735">
        <property type="entry name" value="bMERB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF87">
        <property type="entry name" value="MICAL-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01203">
        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51848">
        <property type="entry name" value="BMERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="106"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="BMERB" evidence="8">
        <location>
            <begin position="712"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="726"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="853" mass="92578" checksum="C9A66DE2CD2070A9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5B8</accession>
    <name>A0A5F8G5B8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19 23">Zinc transporter ZIP9</fullName>
            <shortName evidence="23">ZIP-9</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21 23">Solute carrier family 39 member 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20 23">Zrt- and Irt-like protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SLC39A9</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 23">Cell membrane</location>
            <topology evidence="5 23">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4 23">Cytoplasm</location>
            <location evidence="4 23">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 23">Golgi apparatus</location>
            <location evidence="3 23">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 23">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 23">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 23">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016282659.2">
        <property type="nucleotide sequence ID" value="XM_016427173.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5B8"/>
    <dbReference type="FunCoup" id="A0A5F8G5B8">
        <property type="interactions" value="2447"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042688"/>
    <dbReference type="Ensembl" id="ENSMODT00000064998.1">
        <property type="protein sequence ID" value="ENSMODP00000042688.1"/>
        <property type="gene ID" value="ENSMODG00000050181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100023679"/>
    <dbReference type="CTD" id="55334"/>
    <dbReference type="GeneTree" id="ENSGT00390000010094"/>
    <dbReference type="InParanoid" id="A0A5F8G5B8"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000050181">
        <property type="expression patterns" value="Expressed in uterine wall and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005497">
        <property type="term" value="F:androgen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022883">
        <property type="term" value="F:zinc efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000654">
        <property type="term" value="P:regulation of cellular response to testosterone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905562">
        <property type="term" value="P:regulation of vascular endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF5">
        <property type="entry name" value="ZINC TRANSPORTER ZIP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="23" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 23" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 23" id="KW-0813">Transport</keyword>
    <keyword evidence="11 23" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 23" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00026135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU369011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="320" mass="34112" checksum="32D6C8EF3AD5A056" modified="2019-12-11" version="1">MIRHPFQRITCSRSDRDPVPQARLKDGGWLRRGGPKERLKLITVLGAGLLCGTALAVIVPEGVHALYEDILEDLPEISLHLGKHHQASEAQNVIASDKAVEKPLAHEHEHSHDHTRLHAYIGVSLVLGFVFMLLVDQIGSSHVHSTEDPEGARSNNSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVMAMVTYLGLSKSSKEALSEVNATGVAMLFSAGTFLYVATVHVLPEVGGLGHSHKPDSAGGKGLSRLEVAALVWGCLIPLILSIGHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5C0</accession>
    <name>A0A5F8G5C0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DOP1 leucine zipper like protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DOP1A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000067470.1">
        <property type="protein sequence ID" value="ENSMODP00000042619.1"/>
        <property type="gene ID" value="ENSMODG00000018391.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016421"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018391">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF22">
        <property type="entry name" value="PROTEIN DOPEY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="38"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="302"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like TPR" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1892"/>
            <end position="2253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1237"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1260"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2347" mass="264115" checksum="E9FA0C4B63315CC9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5C3</accession>
    <name>A0A5F8G5C3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin specific peptidase 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">USP31</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5C3"/>
    <dbReference type="Ensembl" id="ENSMODT00000062247.1">
        <property type="protein sequence ID" value="ENSMODP00000042657.1"/>
        <property type="gene ID" value="ENSMODG00000006875.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156355"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006875">
        <property type="expression patterns" value="Expressed in cerebellum and 14 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="585" mass="61844" checksum="9E6281BB70310974" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5C4</accession>
    <name>A0A5F8G5C4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ANXA9</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5C4"/>
    <dbReference type="Ensembl" id="ENSMODT00000084730.1">
        <property type="protein sequence ID" value="ENSMODP00000042616.1"/>
        <property type="gene ID" value="ENSMODG00000018826.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161835"/>
    <dbReference type="OMA" id="CGQFGKE"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018826">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000017">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009116">
        <property type="entry name" value="ANX9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF122">
        <property type="entry name" value="ANNEXIN A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01812">
        <property type="entry name" value="ANNEXINXXXI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="359" mass="39966" checksum="B2851B8652A8CB08" modified="2019-12-11" version="1">MSVSNGKMESSLVHEILSHLGLANKTAAWGTLGTLRPFLSFNVDKDVQRLLEAIAGQGVDQGTIVDVLTNRNGEQRQLIARAFQDRTQQDLLKSLQAALSGSLEKVVVALLKSTAQYDAHELRAALKDINSAEDVGVEILSTRSPPQLKECLTVYKHDFQVEIEDDMRSETSGLLRDLLLALAKGTRESYSGIKDYNLAEQDAHALHEAGETGTGATWIMIFTQRNTEHLNRVFDEYQRQNGQEIEEGIRNCFPGSAQKALLTLGKDMFRITESVGRKVKGSHVSLSCFLFCFTASVIRNTPLYFAEKLHLALQGTEPNHQVLMRILISRSETDLLSIRAEFKKKFGKSLYSSLQVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5C6</accession>
    <name>A0A5F8G5C6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 37 member 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5C6"/>
    <dbReference type="Ensembl" id="ENSMODT00000070346.1">
        <property type="protein sequence ID" value="ENSMODP00000042662.1"/>
        <property type="gene ID" value="ENSMODG00000021023.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159245"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000021023">
        <property type="expression patterns" value="Expressed in spermatid and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000028">
        <property type="entry name" value="Sugar phosphate exchanger 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF11">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="491" mass="53548" checksum="4581EAD7D4E8A6DF" modified="2019-12-11" version="1">MASLPTGIRLITSFTRDQWYRAFIFILTFLLYASFHLSRKPISIVKGELHKHCASHGKVKLNIVNENAFRAPAGKISDNETHCGWAPFDKKNYQQLLGALDYSFLCAYAIGMYLSGIIGERLPIRYYLTFGMFASGAFTALFGLGYFYNIHNFGFYVITQIANGLVQTTGWPSVVTCIGNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGIIIASMGTVCFLFLIEHPRDIKCSSTPLISSKSYENGTNRFRVQKQILYTKDNSKNLDPEIQSLLSDGENGTIQPKFVTVLHGDGGNGMAAISFLGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHFDAKKAGDLSTLFDVGGIIGGILAGVISDRLGKRASTCGLMLLLAAPTGTHKSLKGNSKALSTVTAIIDGTGSVGAALGPLLAGLISPSGWNNVFYMLMVADATALLFLLRLIQKELCCTGSMPGEQRQFKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5C7</accession>
    <name>A0A5F8G5C7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fli-1 proto-onco, ETS transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FLI1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5C7"/>
    <dbReference type="Ensembl" id="ENSMODT00000081504.1">
        <property type="protein sequence ID" value="ENSMODP00000042698.1"/>
        <property type="gene ID" value="ENSMODG00000004763.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158261"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004763">
        <property type="expression patterns" value="Expressed in hindlimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000039">
        <property type="entry name" value="Friend leukemia integration 1 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF161">
        <property type="entry name" value="FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="91"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="262" mass="29442" checksum="F008B81BEA28D5AB" modified="2019-12-11" version="1">MDPGSSLLAYPSTPSHTDQSSRLTAKEDPSYDSVRRTGWNSSMNSGLTKSPPIGGAQNMNKNTEQQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTESPMYKYPSDISYMPSYHAHQQKVNFVPPHPSSMPVSSSSFFGAASQYWTSPTGGIYPNPNVPRHPNTHVPSHLGSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5C9</accession>
    <name>A0A5F8G5C9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat domain 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">WDR17</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5C9"/>
    <dbReference type="Ensembl" id="ENSMODT00000088422.1">
        <property type="protein sequence ID" value="ENSMODP00000042624.1"/>
        <property type="gene ID" value="ENSMODG00000003734.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158602"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003734">
        <property type="expression patterns" value="Expressed in cerebellum and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44464">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44464:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="365"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="538"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="581"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="624"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1202" mass="134166" checksum="BA21A3379F804CAD" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5D0</accession>
    <name>A0A5F8G5D0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin binding LIM protein family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ABLIM2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5D0"/>
    <dbReference type="Ensembl" id="ENSMODT00000073104.1">
        <property type="protein sequence ID" value="ENSMODP00000042667.1"/>
        <property type="gene ID" value="ENSMODG00000003062.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182850"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000003062">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09327">
        <property type="entry name" value="LIM1_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09328">
        <property type="entry name" value="LIM2_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09329">
        <property type="entry name" value="LIM3_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09330">
        <property type="entry name" value="LIM4_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000003">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000007">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000171">
        <property type="entry name" value="Actin-binding LIM protein family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000053">
        <property type="entry name" value="Actin-binding LIM protein family, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF6">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="82"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="151"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="558" mass="62245" checksum="5D8F3A44026CA10D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5D1</accession>
    <name>A0A5F8G5D1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1</fullName>
            <ecNumber evidence="4">2.8.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Glucosaminyl N-deacetylase/N-sulfotransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">NDST1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:21980"/>
            <dbReference type="Rhea" id="RHEA-COMP:9830"/>
            <dbReference type="Rhea" id="RHEA-COMP:14602"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:58388"/>
            <dbReference type="ChEBI" id="CHEBI:140572"/>
            <dbReference type="EC" id="2.8.2.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21981"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Golgi apparatus</location>
            <location evidence="15">trans-Golgi network membrane</location>
            <topology evidence="15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfotransferase 1 family. NDST subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.8" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5D1"/>
    <dbReference type="Ensembl" id="ENSMODT00000063958.1">
        <property type="protein sequence ID" value="ENSMODP00000042626.1"/>
        <property type="gene ID" value="ENSMODG00000009477.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157857"/>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="UniPathway" id="UPA00862"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009477">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015016">
        <property type="term" value="F:heparan sulfate N-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030210">
        <property type="term" value="P:heparin proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021930">
        <property type="entry name" value="Heparan_SO4_deacetylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056793">
        <property type="entry name" value="HSNSD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF30">
        <property type="entry name" value="BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12062">
        <property type="entry name" value="HSNSD-CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25119">
        <property type="entry name" value="HSNSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulfate-N-deacetylase N-terminal" evidence="25">
        <location>
            <begin position="81"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulphate-N-deacetylase deacetylase" evidence="24">
        <location>
            <begin position="307"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="23">
        <location>
            <begin position="597"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="19">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="752"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="768"/>
            <end position="772"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF12062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF25119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="817" mass="93946" checksum="DE67245912BB0E57" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5D2</accession>
    <name>A0A5F8G5D2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NUP107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5D2"/>
    <dbReference type="Ensembl" id="ENSMODT00000077946.1">
        <property type="protein sequence ID" value="ENSMODP00000042665.1"/>
        <property type="gene ID" value="ENSMODG00000007267.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012080"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007267">
        <property type="expression patterns" value="Expressed in spermatid and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="368" mass="41367" checksum="0BC2042B88EC3062" modified="2019-12-11" version="1">MASPMVRDVEVTRTARRQSAHKRVSILTPQEDILANATPRNQMIPRTPNSHCQTLFRSLLRQPDVSAILATGTKSPRLAPLSTSLGNLPMTTNLDESNWTANFSPQRSGIFANNEPSNMTEDVTLSAVMLREDDPGEAATMSMYSDFLHTFLKHASNTVFELIEEYENICESQVNILSKIASRATPGLQKFSKTASVLWLLQQEMVTWRLLASLYKDRIQSVLEEENAFAIASLNASEKTVVDTLFQRDSLIRQSQLVVDWLESIAKDDIGDFSDNIEFYAKSVYWENTLHTLKQRQLISFIGSVRPLVTELAILWGGACGISFLSCWFLSLRAWLYLSISWSLASRSLRGDVKQGDIMESEILFSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5D5</accession>
    <name>A0A5F8G5D5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ArfGAP with dual PH domains 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ADAP2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5D5"/>
    <dbReference type="Ensembl" id="ENSMODT00000053582.1">
        <property type="protein sequence ID" value="ENSMODP00000042703.1"/>
        <property type="gene ID" value="ENSMODG00000019196.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156498"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019196">
        <property type="expression patterns" value="Expressed in lung and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13252">
        <property type="entry name" value="PH1_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000080">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037849">
        <property type="entry name" value="PH1_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF6">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="67"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="167"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="387" mass="44527" checksum="81E2A2FCD6E44E07" modified="2019-12-11" version="1">MLEWKRVSSSDSQTPAQGQVSSTCPLDCEALFPSDAPTTTHSCSPKCPLHPSLTRSRFLAFFSPPADPDWASYKLGIFICLNCSGVHRNFPEISRVKSVRLDFWDDSIVEFMTRNGNLCSKAKYEAKVPAFYYIPQSEDCMVLKEQWIRAKYERQEFVASSLTWTFSGNREGLLWKRGRDNGQYLRRKFVLLTREGLLKYYTKEEGKAPKAVISIKDLNATFQTEKIGNPHGLQITYKRDGHTRNLFVYHENGKEIVDWFNAFRAARLHYLKTAFPELPESELLPHITRNYLKQGYMEKTGPKDAFEQGQVFIGNKEHGYEIHDDVPKGVRGNRWKAGITIVTPERRFVFACPNEKEQREWLESLRHVLALPMTPLNPYATAATGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5D6</accession>
    <name>A0A5F8G5D6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MGAT5B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5D6"/>
    <dbReference type="Ensembl" id="ENSMODT00000072525.1">
        <property type="protein sequence ID" value="ENSMODP00000042631.1"/>
        <property type="gene ID" value="ENSMODG00000001601.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153470"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001601">
        <property type="expression patterns" value="Expressed in cerebellum and 11 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF6">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="15">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="15">
        <location>
            <begin position="225"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="736" mass="83832" checksum="EBA9D085D2B38AA0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5D8</accession>
    <name>A0A5F8G5D8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Integrin subunit alpha 2b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ITGA2B</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5D8"/>
    <dbReference type="Ensembl" id="ENSMODT00000060332.1">
        <property type="protein sequence ID" value="ENSMODP00000042672.1"/>
        <property type="gene ID" value="ENSMODG00000011516.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160724"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011516">
        <property type="expression patterns" value="Expressed in blood and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1510:FF:000001">
        <property type="entry name" value="Integrin alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000001">
        <property type="entry name" value="Integrin subunit alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1460:FF:000001">
        <property type="entry name" value="Integrin, alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF73">
        <property type="entry name" value="INTEGRIN ALPHA-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00357">
        <property type="entry name" value="Integrin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0401">Integrin</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="910"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="248"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="314"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="15">
        <location>
            <begin position="376"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="18">
        <location>
            <begin position="422"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="19">
        <location>
            <begin position="574"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="20">
        <location>
            <begin position="720"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="811"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="949" mass="104088" checksum="E4A79F9932155714" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5D9</accession>
    <name>A0A5F8G5D9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CUGBP Elav-like family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CELF1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CELF/BRUNOL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5D9"/>
    <dbReference type="FunCoup" id="A0A5F8G5D9">
        <property type="interactions" value="2911"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042685"/>
    <dbReference type="Ensembl" id="ENSMODT00000063337.1">
        <property type="protein sequence ID" value="ENSMODP00000042685.1"/>
        <property type="gene ID" value="ENSMODG00000019913.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158970"/>
    <dbReference type="InParanoid" id="A0A5F8G5D9"/>
    <dbReference type="OMA" id="FPCHPAP"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019913">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001673">
        <property type="term" value="C:male germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106222">
        <property type="term" value="F:lncRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12631">
        <property type="entry name" value="RRM1_CELF1_2_Bruno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12634">
        <property type="entry name" value="RRM2_CELF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12638">
        <property type="entry name" value="RRM3_CELF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000013">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000015">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000016">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034196">
        <property type="entry name" value="CELF1/2_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034198">
        <property type="entry name" value="CELF1/2_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034199">
        <property type="entry name" value="CELF1/2_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="135"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="429"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="514" mass="55096" checksum="BF4AC981C429EA1A" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8G5E1</accession>
    <name>A0A5F8G5E1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homolog subfamily C member 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DNAJC10</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8G5E1"/>
    <dbReference type="FunCoup" id="A0A5F8G5E1">
        <property type="interactions" value="1701"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000042629"/>
    <dbReference type="Ensembl" id="ENSMODT00000059200.1">
        <property type="protein sequence ID" value="ENSMODP00000042629.1"/>
        <property type="gene ID" value="ENSMODG00000010507.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155558"/>
    <dbReference type="InParanoid" id="A0A5F8G5E1"/>
    <dbReference type="OMA" id="APTWRKF"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000010507">
        <property type="expression patterns" value="Expressed in uterus and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03004">
        <property type="entry name" value="PDI_a_ERdj5_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd03003">
        <property type="entry name" value="PDI_a_ERdj5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000029">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000087">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000106">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000125">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000135">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000137">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000169">
        <property type="entry name" value="DnaJ homolog subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052460">
        <property type="entry name" value="ER_disulfide_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021170">
        <property type="entry name" value="ERdj5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035674">
        <property type="entry name" value="ERdj5_TRX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035673">
        <property type="entry name" value="ERdj5_TRX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44340">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44340:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037293">
        <property type="entry name" value="DnaJ_homolog_subfam-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="J" evidence="13">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="115"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="439"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="627"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="482"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="590"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="702"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037293-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000042629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="803" mass="93180" checksum="A85DEC69FDA8D987" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWC0</accession>
    <name>A0A5F8GWC0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="8">PARP</shortName>
            <ecNumber evidence="8">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="8"/>
    <dbReference type="Ensembl" id="ENSMODT00000075690.1">
        <property type="protein sequence ID" value="ENSMODP00000051807.1"/>
        <property type="gene ID" value="ENSMODG00000018308.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154311"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000018308">
        <property type="expression patterns" value="Expressed in blood and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000008">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057044">
        <property type="entry name" value="PARP14_KH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057043">
        <property type="entry name" value="PARP14_KH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057045">
        <property type="entry name" value="PARP14_KH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057046">
        <property type="entry name" value="PARP14_KH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057047">
        <property type="entry name" value="PARP14_KH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057048">
        <property type="entry name" value="PARP14_KH_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057049">
        <property type="entry name" value="PARP14_KH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057051">
        <property type="entry name" value="PARP14_RPM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054596">
        <property type="entry name" value="PARP14_WWE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057050">
        <property type="entry name" value="RRM_PARP14_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF89">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23084">
        <property type="entry name" value="KH_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23248">
        <property type="entry name" value="KH_PARP14_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23249">
        <property type="entry name" value="KH_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23251">
        <property type="entry name" value="KH_PARP14_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23252">
        <property type="entry name" value="KH_PARP14_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23253">
        <property type="entry name" value="KH_PARP14_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23254">
        <property type="entry name" value="KH_PARP14_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23222">
        <property type="entry name" value="RRM_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23245">
        <property type="entry name" value="RRM_PARP14_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22005">
        <property type="entry name" value="WWE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="12">
        <location>
            <begin position="786"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="12">
        <location>
            <begin position="1221"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="10">
        <location>
            <begin position="1494"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="11">
        <location>
            <begin position="1576"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1769" mass="199850" checksum="6D76223F043A25A9" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWC1</accession>
    <name>A0A5F8GWC1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 4H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EIF4H</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWC1"/>
    <dbReference type="Ensembl" id="ENSMODT00000077372.1">
        <property type="protein sequence ID" value="ENSMODP00000051968.1"/>
        <property type="gene ID" value="ENSMODG00000013851.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155414"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013851">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12401">
        <property type="entry name" value="RRM_eIF4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000115">
        <property type="entry name" value="eukaryotic translation initiation factor 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034229">
        <property type="entry name" value="eIF4H_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="177"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="256"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="365" mass="39508" checksum="C42F675E1BA214DB" modified="2019-12-11" version="1">MVREAGQHTMEPGRGARRRRREVEEGGEPREEGERSRARPNPAQPSPAQPSRRAAGAAWRHGAACVRACVRACARAAAAAAAAAAAAYVRTCVRADGLRSGSAAGSPGRGAGRGGELYCGVLPRSPWFLSERRRQMADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSVRSVRLVRDKETDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGFKDDFLGGRGGGSRPGDRRTGGPPMGSRFRDGPPLRGSSMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVHKEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWC2</accession>
    <name>A0A5F8GWC2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ceramide transfer protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Collagen type IV alpha-3-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CERT1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-enine(out)</text>
            <dbReference type="Rhea" id="RHEA:45720"/>
            <dbReference type="ChEBI" id="CHEBI:72959"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWC2"/>
    <dbReference type="Ensembl" id="ENSMODT00000075130.1">
        <property type="protein sequence ID" value="ENSMODP00000051870.1"/>
        <property type="gene ID" value="ENSMODG00000002107.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155123"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002107">
        <property type="expression patterns" value="Expressed in extraembryonic membrane and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13283">
        <property type="entry name" value="PH_GPBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000104">
        <property type="entry name" value="collagen type IV alpha-3-binding protein-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000003">
        <property type="entry name" value="Collagen type IV alpha-3-binding protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF53">
        <property type="entry name" value="CERAMIDE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="16">
        <location>
            <begin position="416"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="585" mass="66354" checksum="210A706192DF440E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWC5</accession>
    <name>A0A5F8GWC5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPS20</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWC5"/>
    <dbReference type="Ensembl" id="ENSMODT00000065622.1">
        <property type="protein sequence ID" value="ENSMODP00000051812.1"/>
        <property type="gene ID" value="ENSMODG00000045434.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003248"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000045434">
        <property type="expression patterns" value="Expressed in hindlimb bud and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="61" mass="6786" checksum="C789D326ECA9DF24" modified="2019-12-11" version="1">MAFKDTGKAPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGAEPEEHCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWC6</accession>
    <name>A0A5F8GWC6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dedicator of cytokinesis 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DOCK9</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000052655.1">
        <property type="protein sequence ID" value="ENSMODP00000051973.1"/>
        <property type="gene ID" value="ENSMODG00000008269.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155972"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008269">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08697">
        <property type="entry name" value="C2_Dock-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11698">
        <property type="entry name" value="DHR2_DOCK9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13267">
        <property type="entry name" value="PH_DOCK-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000016">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000015">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037809">
        <property type="entry name" value="C2_Dock-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF77">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="170"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="7">
        <location>
            <begin position="636"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="8">
        <location>
            <begin position="1601"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1911"/>
            <end position="1938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2066" mass="236332" checksum="0E3F380B0BA3B281" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWC7</accession>
    <name>A0A5F8GWC7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">N-terminal EF-hand calcium-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NECAB1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with STX1. May interact with CPNE6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_056679313.1">
        <property type="nucleotide sequence ID" value="XM_056823335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWC7"/>
    <dbReference type="FunCoup" id="A0A5F8GWC7">
        <property type="interactions" value="1091"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051875"/>
    <dbReference type="Ensembl" id="ENSMODT00000067800.1">
        <property type="protein sequence ID" value="ENSMODP00000051875.1"/>
        <property type="gene ID" value="ENSMODG00000007570.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100022014"/>
    <dbReference type="CTD" id="64168"/>
    <dbReference type="GeneTree" id="ENSGT00950000183131"/>
    <dbReference type="InParanoid" id="A0A5F8GWC7"/>
    <dbReference type="OMA" id="EDSQWMI"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007570">
        <property type="expression patterns" value="Expressed in spinal cord and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001835">
        <property type="term" value="P:blastocyst hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000025">
        <property type="entry name" value="N-terminal EF-hand calcium-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000642">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039862">
        <property type="entry name" value="NECAB1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12178">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12178:SF11">
        <property type="entry name" value="N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="12">
        <location>
            <begin position="252"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="401" mass="46184" checksum="36D3701DFB0A6038" modified="2019-12-11" version="1">MEDSQETSPSSNNSSEELSSALQLSKGMSIFLDILRRADKNDDGKLSFEEFKAYFADGVLSGEELRELFHTIDTHNTNNLDTEELCEYFSQHLGEYENVLAALEDLNLSILKAMSKTKKDYQEASNLEQFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPIKPEVLSIPWPGKRSNRRVQRHSSFSPNSPQFHMCGPGLLEEDNQWMTQINRLQKLIDRLEKKDIKLEPLEEEIFEGNTKSHILLVQRQMSVVEEDLEEFHLALKQYVESASSQSGCLHVSIQKLSNESRFIVYEFWENSSVWNSHLQMNYCKAFQRSNVDFLETPELTSTMLVPGNYAGFYNTPHSFSILFPLTSPRPVLFSSILVSALFFNYSIPSLQLKCPFRKGFLHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWC9</accession>
    <name>A0A5F8GWC9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">KIAA0825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">KIAA0825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWC9"/>
    <dbReference type="Ensembl" id="ENSMODT00000088568.1">
        <property type="protein sequence ID" value="ENSMODP00000051446.1"/>
        <property type="gene ID" value="ENSMODG00000020128.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00610000086112"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020128">
        <property type="expression patterns" value="Expressed in spermatocyte and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027993">
        <property type="entry name" value="DUF4495"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960:SF1">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="343" mass="39396" checksum="57D046C36C0196F2" modified="2019-12-11" version="1">MDWGDEYSYNSFDVDCLLNSFPGDVEFEQIFSDIDEKIEKNAASLKQCLKDIQSEVNKRCGSDVPLQTTSDCLEWLNNYSSSSLKPPSCPHGDLIKFLKTLQDLLKNEQNQEEMILDFLLDLSSQCGVSFPRTPSGTSFLFTSRTSLHAVEDHSSMDVKSLWDDIRLHLRRFLLNKLQGHDKVNNSPQTISFKTHCIQQLLFLYPESEVLAKYQSLQNKMVIQLLENCFLSYNREANLDTVMHGYQNSILKLCKMIKQDFYVLSEILAPSSALKFINETYLDSIKEEMTNFLERFCELQFKENTVHVVKTGRSSSKHRGAVHALAHPIMTTMFPVNGVWIKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWD0</accession>
    <name>A0A5F8GWD0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Voltage-dependent R-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CACNA1E</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000088247.1">
        <property type="protein sequence ID" value="ENSMODP00000051817.1"/>
        <property type="gene ID" value="ENSMODG00000006729.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155601"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006729">
        <property type="expression patterns" value="Expressed in cerebellum and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000059">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000011">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000013">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000015">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000023">
        <property type="entry name" value="Voltage-dependent R-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005449">
        <property type="entry name" value="VDCC_R_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF5">
        <property type="entry name" value="VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01633">
        <property type="entry name" value="RVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="810"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="871"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="983"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1064"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1094"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1123"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1188"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1281"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="1321"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="954"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1511" mass="173060" checksum="95C5F7B4C1EA6726" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWD1</accession>
    <name>A0A5F8GWD1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">FYVE, RhoGEF and PH domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FGD1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWD1"/>
    <dbReference type="Ensembl" id="ENSMODT00000062545.1">
        <property type="protein sequence ID" value="ENSMODP00000051880.1"/>
        <property type="gene ID" value="ENSMODG00000020895.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159438"/>
    <dbReference type="OMA" id="QQRWMAV"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020895">
        <property type="expression patterns" value="Expressed in spinal cord and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15741">
        <property type="entry name" value="FYVE_FGD1_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13236">
        <property type="entry name" value="PH2_FGD1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000061">
        <property type="entry name" value="FYVE, RhoGEF and PH domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000013">
        <property type="entry name" value="FYVE, RhoGEF and PH domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000102">
        <property type="entry name" value="FYVE, RhoGEF and PH domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035941">
        <property type="entry name" value="FGD1-4_PH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF79">
        <property type="entry name" value="FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="15">
        <location>
            <begin position="354"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="571"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="16">
        <location>
            <begin position="711"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="802"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="108"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="231"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="949" mass="103912" checksum="9B93B7C0BA97CF44" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWD7</accession>
    <name>A0A5F8GWD7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TBC1 domain family member 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TBC1D19</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWD7"/>
    <dbReference type="Ensembl" id="ENSMODT00000071882.1">
        <property type="protein sequence ID" value="ENSMODP00000051885.1"/>
        <property type="gene ID" value="ENSMODG00000000109.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015965"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000109">
        <property type="expression patterns" value="Expressed in spermatocyte and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042507">
        <property type="entry name" value="TBC1D19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="214"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="489" mass="56302" checksum="058C0CCE6181D310" modified="2019-12-11" version="1">MLQEEEDLSLTIAQIVQKLKGSRLYAQLERQAWVSLQKPEIKLETLKEDIKEFFRITGWEKKLHNAVYSELTVFPLPRHPAAPPEHLKEPLVYMRKAQGSWEKRILKSLNSMCTELSIPLARKRPVVEQKELLNKWNEMGTDEPDLSLFRPVYAPKDFLEKEFFVELSLNTGQLGIDDATQVPPELFENEHVRLGQKVLAEQDSAAAQQYIRQGSPTALRAELWALILNVSNQPEDLLYYEQLKSNVIQHDLLVDSLIYKDVKLTASNDDYYFVFEDYLYQVLLCFSRDTAVLGHFAYNSASPPKSYIRGKLGMEDYAVFYPPNGVIPFHGFSMYVAPLCFLYHEPSKLYQIFREMYVRFFFRLHSISSHHSGIVSLCLLFETLLQTHLPQLFYHLREIGAQPLRISFKWMVRAFSGYLATDQLLLLWDRILGYNSLEILAVLAAAVFAFRAVNLMEVTSLAAAEAVLADLSTLKVMPLLQIFLFATVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWD8</accession>
    <name>A0A5F8GWD8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain containing 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MFSD8</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWD8"/>
    <dbReference type="Ensembl" id="ENSMODT00000084967.1">
        <property type="protein sequence ID" value="ENSMODP00000051669.1"/>
        <property type="gene ID" value="ENSMODG00000012271.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063854"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012271">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="408" mass="44431" checksum="F39FCF724663A59E" modified="2019-12-11" version="1">MFLSSVGFSIVIMSVWPYLQKIDPTADASFLGWIIASYSLGQMVASPLFGLWSNYRPRKEPLVISIFISVAANCLYAYVHVPPSHNKYYMLVARALVGFGAGNVAVVRSYIAGATSLQERTGAMANTSASQALGFILGPANPDEVHDAQGSIDQVAVITTNILFFIILFIFALFETIATPLTMDMYAWTREQAVLYNGIILAALGVEAVMVFMGIKILSKRAGERALLLGGLVVVFIGFFILLPWGSQFPKIQWEDLHNDSISDAPAAERAPYLWTLPAGNSSEGPTGCPVRQSWCLSTPVIHLAQFLVAAVLIGMGYPACNVMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPVFVSQMYTYCGPRWSFSLVCAIILLTVVLLGAVYRRLIPFSVRHGRVQEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWE1</accession>
    <name>A0A5F8GWE1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SLC9A5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWE1"/>
    <dbReference type="FunCoup" id="A0A5F8GWE1">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051674"/>
    <dbReference type="Ensembl" id="ENSMODT00000072542.1">
        <property type="protein sequence ID" value="ENSMODP00000051674.1"/>
        <property type="gene ID" value="ENSMODG00000006020.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159190"/>
    <dbReference type="InParanoid" id="A0A5F8GWE1"/>
    <dbReference type="OMA" id="AMHHLLC"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006020">
        <property type="expression patterns" value="Expressed in cerebellum and 13 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044309">
        <property type="term" value="C:neuron spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990763">
        <property type="term" value="F:arrestin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018410">
        <property type="entry name" value="Na/H_exchanger_3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF56">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01087">
        <property type="entry name" value="NAHEXCHNGR3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="12 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="16">
        <location>
            <begin position="55"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="679"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="855"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="917" mass="100139" checksum="F5DA5FBADC8A44F3" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWE2</accession>
    <name>A0A5F8GWE2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000065753.1">
        <property type="protein sequence ID" value="ENSMODP00000051461.1"/>
        <property type="gene ID" value="ENSMODG00000027995.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157188"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000027995">
        <property type="expression patterns" value="Expressed in liver and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF5">
        <property type="entry name" value="DEXD_H-BOX HELICASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26167">
        <property type="entry name" value="TPR_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023936456" description="Helicase ATP-binding domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="680"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1439" mass="167624" checksum="7435C8FCC3D262DE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWE4</accession>
    <name>A0A5F8GWE4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MHC class II family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWE4"/>
    <dbReference type="Ensembl" id="ENSMODT00000081615.1">
        <property type="protein sequence ID" value="ENSMODP00000051679.1"/>
        <property type="gene ID" value="ENSMODG00000046464.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161821"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002504">
        <property type="term" value="P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05767">
        <property type="entry name" value="IgC1_MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.320.10">
        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001003">
        <property type="entry name" value="MHC_II_a_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF59">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00993">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00920">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0491">MHC II</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023834697" description="Ig-like domain-containing protein" evidence="12">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="117"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="258" mass="29270" checksum="315D516531188E36" modified="2019-12-11" version="1">VYNFLSLFLACLALELVPCLCHKRILVELPLSDHMDTFGTTVYQSYGPSGQYTNDFDEDELFYVDLKKKETVWRLPEFGNFAKFDPWGGLRNSAMMKNILDLLMRKSNYTADPNEVPEVTVFSRTPIELGQPNTLICFINNIFPPVINITWQQNGQRVTTGVMETNFYPQTDNSFQKLSYLTFIPSTEDVYGCKVEHWGLSLFPESLMPIPLPETTETLTCALKLTVGLLGIIVSTILIARTSITRHPDPHTLALFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWE5</accession>
    <name>A0A5F8GWE5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromodomain containing 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BRD10</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000065347.1">
        <property type="protein sequence ID" value="ENSMODP00000051837.1"/>
        <property type="gene ID" value="ENSMODG00000015293.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011483"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015293">
        <property type="expression patterns" value="Expressed in skeleton of lower jaw and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040214">
        <property type="entry name" value="BRD10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056522">
        <property type="entry name" value="KIAA2026_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31095">
        <property type="entry name" value="RIKEN CDNA 9930021J03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31095:SF3">
        <property type="entry name" value="RIKEN CDNA 9930021J03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23450">
        <property type="entry name" value="KIAA2026_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="148"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Uncharacterized bromodomain-containing protein 10 helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="740"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="872"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1223"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1431"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="740"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="872"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="951"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1223"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1450"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2104" mass="227663" checksum="2D550059E09B8AEB" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWE6</accession>
    <name>A0A5F8GWE6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Crystallin zeta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CRYZ</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWE6"/>
    <dbReference type="Ensembl" id="ENSMODT00000081680.1">
        <property type="protein sequence ID" value="ENSMODP00000051684.1"/>
        <property type="gene ID" value="ENSMODG00000019078.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154882"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000019078">
        <property type="expression patterns" value="Expressed in testis and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08253">
        <property type="entry name" value="zeta_crystallin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="12"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="307" mass="32117" checksum="449729570E529F75" modified="2025-10-08" version="2">MGVSELPGSRVGRAGGAGPPLRAPPMTPCHPQILIKVHACGVNPVETYIRSGTYSRVPTLPYTPGSDVAGVVEALGRGVDGFKKGDRVFTTKTITGGYAEYTVASVHTVFPLPETLSFSQGAALGIPYFTAFRALFHKAQARPGETVLVHGASGGVGIATCQIARAYGLKVLGTAGTDQGRKVVLKSGAHKIFNHREAGYVDRIQVVNVIIEMVSNVNLHNDLHLLSYGGRVIVSSAPPWGPGATALSVCATQEDFLETLSALLAGIESGWLQPVIGSHYLLENAAKAHEDIIKSAGAAGKMVLLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWE7</accession>
    <name>A0A5F8GWE7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ heat shock protein family (Hsp40) member C15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DNAJC15</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWE7"/>
    <dbReference type="FunCoup" id="A0A5F8GWE7">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051890"/>
    <dbReference type="Ensembl" id="ENSMODT00000062850.1">
        <property type="protein sequence ID" value="ENSMODP00000051890.1"/>
        <property type="gene ID" value="ENSMODG00000014875.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159907"/>
    <dbReference type="InParanoid" id="A0A5F8GWE7"/>
    <dbReference type="OMA" id="XRCAFQI"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000014875">
        <property type="expression patterns" value="Expressed in skeletal muscle tissue and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902957">
        <property type="term" value="P:negative regulation of mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031333">
        <property type="term" value="P:negative regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="156" mass="17430" checksum="50E301BCE7AC5ADA" modified="2019-12-11" version="1">MAGRGAGPADENLRYAEYMSHAAKRPESDFDQGLARTLIAVGLGVAAFAFAGRYAFQIWKPLEQVITETAKKIQSPSLSSYYKGGFEQKMSRREASLILGISPSAGKAKIRTAHRRIMILNHPDKDSAPDFAFDRSYLLFTLKARRWISLFSNQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWE8</accession>
    <name>A0A5F8GWE8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin related protein 3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ACTR3B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWE8"/>
    <dbReference type="Ensembl" id="ENSMODT00000056305.1">
        <property type="protein sequence ID" value="ENSMODP00000051988.1"/>
        <property type="gene ID" value="ENSMODG00000004852.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158304"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004852">
        <property type="expression patterns" value="Expressed in cerebellum and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000315">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000803">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000002">
        <property type="entry name" value="actin-related protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="378" mass="43360" checksum="ED44B7A5011FBD2C" modified="2019-12-11" version="1">MEKSNRYTKLGYAGNTEPQFIIPSCIAIRESAKVVDQAQRRVLRGVDDLDFFIGDEAIDKPTYATKWPIRHGIIEDWDLMERFMEQVIFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDARKWIKQYTGINAINQKKFIIDVGYERFLGPEIFFHPENVVLSGGSTMFRDFGRRLQRDLKRVVDARLKLSEELSGGRIKPKPVEVQVITHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWE9</accession>
    <name>A0A5F8GWE9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWE9"/>
    <dbReference type="Ensembl" id="ENSMODT00000073490.1">
        <property type="protein sequence ID" value="ENSMODP00000051466.1"/>
        <property type="gene ID" value="ENSMODG00000041835.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000188864"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="295" mass="29333" checksum="DC64FE19AA01C7CD" modified="2019-12-11" version="1">ASLLTLSNICLPSSCPGGSSWQLDDCPESCCEPCGGCGPSCCPASCCPPASCLTLVCRPVCCMPASCQPCPAVCTPSCCQSTGCGASCCQTCPCPSCCISLPVCCKPSCCVISACPAPSCCPVPSCCQPPCCVSLTCQPACSPATCCVPLSCKPTCSVCAPSCCQSTGCGASCCQTCPSAPIQSCCCVPMCCKPSCCISLPVCCKPSCCVTSACPVLSCSPVPSCCQPPCCQPAGSMPLSCRPVCSPATCCVPLSCKPTCCTTSSSYCCCGPSCCCPTCCRPSCCSTSCGQKSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWF0</accession>
    <name>A0A5F8GWF0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWF0"/>
    <dbReference type="Ensembl" id="ENSMODT00000061175.1">
        <property type="protein sequence ID" value="ENSMODP00000051842.1"/>
        <property type="gene ID" value="ENSMODG00000029615.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064407"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000029615">
        <property type="expression patterns" value="Expressed in forelimb bud and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039938">
        <property type="entry name" value="Sp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14947">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14947:SF24">
        <property type="entry name" value="ZINC FINGER PROTEIN 781-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="2">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="292" mass="33749" checksum="04131399D533F7A3" modified="2019-12-11" version="1">MAFERDRLPAQEVLTFKDVAVDFTREEWHLLSPSQKKLYEEVMLENARNLLSVEGETRPEMKVNPTEMSPSVEEMDVQRFMSDGPDNFAFKKFFVAPQHSSRIEHHRTHTEEKSSETNQSQRFYAQGQPCWTSKDPPWRRNLMMQLCGKTFTNTPILLYIRESTLGRNLMNATNVERHSQITPVLLYIRKSTLVRNLMNANNVERHSIGGTILLYIRESTLGRNLMNATNVERHSVGRTILLYIRESILGRNLMNANSVERHSISAPGLFTIRECTLGRNLMNASNVERHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWF1</accession>
    <name>A0A5F8GWF1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 150</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWF1"/>
    <dbReference type="Ensembl" id="ENSMODT00000056880.1">
        <property type="protein sequence ID" value="ENSMODP00000051689.1"/>
        <property type="gene ID" value="ENSMODG00000012183.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005285"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000012183">
        <property type="expression patterns" value="Expressed in spermatocyte and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038807">
        <property type="entry name" value="CCDC150"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35352">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35352:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="590" mass="68991" checksum="478BD5F40C786D0D" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWF2</accession>
    <name>A0A5F8GWF2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RuvB-like helicase</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RUVBL1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWF2"/>
    <dbReference type="Ensembl" id="ENSMODT00000062281.1">
        <property type="protein sequence ID" value="ENSMODP00000051471.1"/>
        <property type="gene ID" value="ENSMODG00000008018.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153556"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008018">
        <property type="expression patterns" value="Expressed in forelimb bud and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TIP49 P-loop" evidence="12">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="TIP49 P-loop" evidence="12">
        <location>
            <begin position="48"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="RuvB-like AAA-lid" evidence="13">
        <location>
            <begin position="345"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="427" mass="47406" checksum="E4FF2BAB59138006" modified="2019-12-11" version="1">MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENARETALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAIGLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESLQKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTLHDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLFVDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDVISPHGIPLDLLDRVMIIRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKINGKDSIEKEHVEEINELFYDAKSSAKILADQQDKYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWF3</accession>
    <name>A0A5F8GWF3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GBE1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWF3"/>
    <dbReference type="Ensembl" id="ENSMODT00000079951.1">
        <property type="protein sequence ID" value="ENSMODP00000051694.1"/>
        <property type="gene ID" value="ENSMODG00000016876.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017040"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016876">
        <property type="expression patterns" value="Expressed in liver and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000550">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="226"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="668" mass="76497" checksum="66D8FBBE051B8E49" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWF7</accession>
    <name>A0A5F8GWF7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SNX3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_001368422.1">
        <property type="nucleotide sequence ID" value="XM_001368385.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWF7"/>
    <dbReference type="FunCoup" id="A0A5F8GWF7">
        <property type="interactions" value="1836"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051476"/>
    <dbReference type="Ensembl" id="ENSMODT00000074664.1">
        <property type="protein sequence ID" value="ENSMODP00000051476.1"/>
        <property type="gene ID" value="ENSMODG00000044688.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100021642"/>
    <dbReference type="KEGG" id="mdo:100021642"/>
    <dbReference type="CTD" id="8724"/>
    <dbReference type="GeneTree" id="ENSGT00940000153609"/>
    <dbReference type="InParanoid" id="A0A5F8GWF7"/>
    <dbReference type="OMA" id="VGRQRYT"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000044688">
        <property type="expression patterns" value="Expressed in blood and 22 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032009">
        <property type="term" value="C:early phagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905394">
        <property type="term" value="F:retromer complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046597">
        <property type="term" value="P:host-mediated suppression of symbiont invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010324">
        <property type="term" value="P:membrane invagination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000642">
        <property type="term" value="P:negative regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050765">
        <property type="term" value="P:negative regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042177">
        <property type="term" value="P:negative regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051224">
        <property type="term" value="P:negative regulation of protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022615">
        <property type="term" value="P:protein to membrane docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030111">
        <property type="term" value="P:regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07293">
        <property type="entry name" value="PX_SNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000002">
        <property type="entry name" value="Sorting nexin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042137">
        <property type="entry name" value="PX_SNX3_Vert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF1">
        <property type="entry name" value="SORTING NEXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PX" evidence="15">
        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="162" mass="18721" checksum="9C7CD0A5F64A52AC" modified="2019-12-11" version="1">MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESSVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDSFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWF9</accession>
    <name>A0A5F8GWF9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transmembrane protein 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TMEM68</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWF9"/>
    <dbReference type="Ensembl" id="ENSMODT00000064561.1">
        <property type="protein sequence ID" value="ENSMODP00000051900.1"/>
        <property type="gene ID" value="ENSMODG00000009183.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011782"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009183">
        <property type="expression patterns" value="Expressed in uterine wall and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753:SF14">
        <property type="entry name" value="MONOACYLGLYCEROL_DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="97" mass="11444" checksum="B86318AC3C12B037" modified="2019-12-11" version="1">MFTQNIREGFRSLGGTRLFRWLYEKFRYPFAPIYGGFPVKLRTYLGDPIPYDPKVTAEQLAEKTKNAVQELIDRHQRIPGNIMSALLERFHKKQEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWG1</accession>
    <name>A0A5F8GWG1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of G-protein signaling 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RGS5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWG1"/>
    <dbReference type="FunCoup" id="A0A5F8GWG1">
        <property type="interactions" value="1139"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000051852"/>
    <dbReference type="Ensembl" id="ENSMODT00000070907.1">
        <property type="protein sequence ID" value="ENSMODP00000051852.1"/>
        <property type="gene ID" value="ENSMODG00000001208.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157380"/>
    <dbReference type="InParanoid" id="A0A5F8GWG1"/>
    <dbReference type="OMA" id="FIIPYPD"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001208">
        <property type="expression patterns" value="Expressed in uterus and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08717">
        <property type="entry name" value="RGS_RGS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.196.10:FF:000001">
        <property type="entry name" value="Regulator of G-protein signaling 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034956">
        <property type="entry name" value="RGS_RGS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF42">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="RGS" evidence="8">
        <location>
            <begin position="65"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="227" mass="26481" checksum="AA88DF93454CDFD9" modified="2019-12-11" version="1">MRSYWEIILSGFFSCRAKEIKTKLGTLLQKPDATIDLIIPYPDKPEKPVKTQKPSPEEALQWRDSLEKLLQNNYGLASFKSFLKSEFSEENIEFWIACEDYKKTKSPIKMAEKAKKIYEEFIRAEAPKEVNIDHFTKAMTMKNLVEPSPSSFDMAQKRIHALMEKDSLPRFIRSEFYQELIKSLLTLEMFQILWTLLLIGQSQKKVPRASMLTSFLDLHLTLQTFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWG2</accession>
    <name>A0A5F8GWG2_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC103096484</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWG2"/>
    <dbReference type="Ensembl" id="ENSMODT00000088114.1">
        <property type="protein sequence ID" value="ENSMODP00000051998.1"/>
        <property type="gene ID" value="ENSMODG00000048003.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155965"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000048003">
        <property type="expression patterns" value="Expressed in spinal cord and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003698">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001890">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000350">
        <property type="entry name" value="Zinc finger protein 699"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF71">
        <property type="entry name" value="NOVEL KRAB BOX AND ZINC FINGER, C2H2 TYPE DOMAIN CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="664" mass="75464" checksum="EAF9187145E25021" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWG5</accession>
    <name>A0A5F8GWG5_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 1 regulatory subunit 12B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PPP1R12B</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWG5"/>
    <dbReference type="Ensembl" id="ENSMODT00000057792.1">
        <property type="protein sequence ID" value="ENSMODP00000052003.1"/>
        <property type="gene ID" value="ENSMODG00000000662.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157067"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000662">
        <property type="expression patterns" value="Expressed in heart and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031775">
        <property type="entry name" value="PRKG1_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF18">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15898">
        <property type="entry name" value="PRKG1_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="cGMP-dependent protein kinase interacting" evidence="6">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000052003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="194" mass="22141" checksum="E55ACF634E81D493" modified="2019-12-11" version="1">MSSLYTRSKEFTRNRKSQSDSPPASPSPIAKTLRHERLSRLESGSSSLTSTDTYSDRASAKARREARIASLTSRVEEDSQRDYKRLYESALTENQKLKTKLQEAQQELAEVKSKLEKVAQKQEKTSDRSTMLEMEKRVCIFLSPLLSLFLFLLSLALLFLPTEKVHLKKALSVLPYSIFNLMRNSFCLSLISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWG6</accession>
    <name>A0A5F8GWG6_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sushi domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SUSD1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWG6"/>
    <dbReference type="Ensembl" id="ENSMODT00000060303.1">
        <property type="protein sequence ID" value="ENSMODP00000051857.1"/>
        <property type="gene ID" value="ENSMODG00000005525.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013892"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005525">
        <property type="expression patterns" value="Expressed in blood and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000068">
        <property type="entry name" value="Latent transforming growth factor beta binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF5">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0768">Sushi</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023843875" evidence="12">
        <location>
            <begin position="47"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="193"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="253"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="721" mass="80280" checksum="3BC852D89E858253" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWG7</accession>
    <name>A0A5F8GWG7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWG7"/>
    <dbReference type="Ensembl" id="ENSMODT00000088739.1">
        <property type="protein sequence ID" value="ENSMODP00000051910.1"/>
        <property type="gene ID" value="ENSMODG00000004349.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286974"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000004349">
        <property type="expression patterns" value="Expressed in cerebellum and 15 other cell types or tissues"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000033">
        <property type="entry name" value="Killer cell immunoglobulin-like receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050412">
        <property type="entry name" value="Ig-like_Receptors_ImmuneReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738">
        <property type="entry name" value="MHC CLASS I NK CELL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738:SF157">
        <property type="entry name" value="T-CELL-INTERACTING, ACTIVATING RECEPTOR ON MYELOID CELLS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="126"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="270" mass="29517" checksum="D7EEE161AA97B7D5" modified="2019-12-11" version="1">HGPKEFLEIWTLFPFQTPFPDPPSGLWAQPGLVVVPGTDVTLWCSRPKLLSPQEKNFTLWKAGRQQPLQNRSSAQAWTGFLLSSVGLEDAGSYRCAYGEPRGSARDSEPSDALELMVTGEGSLPKPSLSALPSLVVEPGTHLTLQCRQPLQSPLWGVTFALLKAGTPQPLQSQSPAGTSAVFPLLSVRAQDAGNYSCIYHGKEGSQVSEPSEVLEIWVTDSIEKDYTMENLIQIGLATLILIILGFILGDACNDWRRSEDKSSKRDPRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWG8</accession>
    <name>A0A5F8GWG8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HIBADH</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWG8"/>
    <dbReference type="Ensembl" id="ENSMODT00000062927.1">
        <property type="protein sequence ID" value="ENSMODP00000051709.1"/>
        <property type="gene ID" value="ENSMODG00000000340.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155255"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000000340">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000912">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="42"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="182" mass="19507" checksum="2CAD61A1B09831F3" modified="2019-12-11" version="1">MAAALCLRGAARSLLGRGRRQCAGRVSLAAVCSRSMASKTPVGFVGLGNMGNPMAKNLMKHGYPLIIYDVFPEACKDFQDVGQVMASPADVAEKADRIITMLPTSLNAIEVYTGPNGILRKVKKGSLLIDSSTIDPSVSKELAKEVEKMGALFMDAPVSGETALRDLTKLQERRLTTPKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWG9</accession>
    <name>A0A5F8GWG9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">EMC1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWG9"/>
    <dbReference type="Ensembl" id="ENSMODT00000079042.1">
        <property type="protein sequence ID" value="ENSMODP00000051486.1"/>
        <property type="gene ID" value="ENSMODG00000015866.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002461"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000015866">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000856">
        <property type="entry name" value="ER membrane protein complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023817806" description="ER membrane protein complex subunit 1" evidence="13">
        <location>
            <begin position="22"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="15">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="15">
        <location>
            <begin position="74"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="14">
        <location>
            <begin position="765"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000051486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="971" mass="109058" checksum="14EDAFF3E1683CEE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8GWH1</accession>
    <name>A0A5F8GWH1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitric oxide synthase 1 adaptor protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8GWH1"/>
    <dbReference type="Ensembl" id="ENSMODT00000081652.1">
        <property type="protein sequence ID" value="ENSMODP00000052008.1"/>
        <property type="gene ID" value="ENSMODG00000001013.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000046975"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001013">
        <property type="expression patterns" value="Expressed in spermatocyte and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027851">
        <property type="entry name" value="DUF4628"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15429">
        <property type="entry name" value="DUF4628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000052008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="309" mass="32998" checksum="7D2FF51AF6F42D64" modified="2019-12-11" version="1">MEEKYSSMSSSPPPVEFDQSMFENSNTAPTPKLQPSRSFPHLSKSTAPSSTTMGPLEPSGPGLRMGSSQHLKNLGKAMGAKVNDFLRRKEPVNLGNAAGVMEINTNAGATLSAPGDPPPGTWQEEERSVLLEAFPRLDPPPPVTKKRTPRALKNPQDMLISPQPIVSSLEYGAELSAGPLQEPPSTAPSLGELVSDDNLGPEGSLETVSDTEALPNGEVPLSVPDLIHKDTQSDFKLRTSEWRRASSPSLSERNGLKLSLGPISLTEPQEDGSPLPRARTTSLDNEGPHPDLLSFESLVVLPSCGQETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8C0</accession>
    <name>A0A5F8H8C0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Prostaglandin E synthase</fullName>
            <ecNumber evidence="7">2.5.1.18</ecNumber>
            <ecNumber evidence="6">5.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Glutathione peroxidase PTGES</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Glutathione transferase PTGES</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Microsomal prostaglandin E synthase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="29">Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Plays a key role in inflammation response, fever and pain. Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:48620"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57450"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:90632"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:53324"/>
            <dbReference type="ChEBI" id="CHEBI:85166"/>
            <dbReference type="ChEBI" id="CHEBI:137172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:53325"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:64364"/>
            <dbReference type="ChEBI" id="CHEBI:82629"/>
            <dbReference type="ChEBI" id="CHEBI:152564"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:64365"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>prostaglandin H2 = prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:12893"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="5.3.99.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:12894"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MAPEG family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="7"/>
    <dbReference type="EC" id="5.3.99.3" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8C0"/>
    <dbReference type="Ensembl" id="ENSMODT00000083773.1">
        <property type="protein sequence ID" value="ENSMODP00000056210.1"/>
        <property type="gene ID" value="ENSMODG00000006776.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100015030"/>
    <dbReference type="CTD" id="9536"/>
    <dbReference type="GeneTree" id="ENSGT00390000011980"/>
    <dbReference type="OrthoDB" id="193139at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000006776">
        <property type="expression patterns" value="Expressed in placenta and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050220">
        <property type="term" value="F:prostaglandin-E synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000002">
        <property type="entry name" value="Microsomal glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040162">
        <property type="entry name" value="MGST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689:SF9">
        <property type="entry name" value="PROSTAGLANDIN E SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 30" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00039926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00041613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00042011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00042173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00054772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="178" mass="20093" checksum="A775FABDFF5A3197" modified="2019-12-11" version="1">MSSDLRNLNSFMTGSPPFGQALEGDKAPASAHKMMDNEVFVNFLLYSTILVIKMYLVAVITGQVRLRKKAFANPEDALKHGGLQFCRTDPDVERCRRAHGNDLENILPFLFLGSIYSFLNPDPFIAWLHFFIFFVGRIIHTVAYLVKLKAPIRSVAYTVAQVPCVSMALQILWEVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8C3</accession>
    <name>A0A5F8H8C3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Teneurin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Protein Odd Oz/ten-m homolog 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Tenascin-M2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="33">Teneurin transmembrane protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="primary">TENM2</name>
    </gene>
    <organism evidence="40 41">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="40 41" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="40" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="40" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="29">Induces gene transcription inhibition.</text>
    </comment>
    <comment type="function">
        <text evidence="34">Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the ADGRL1 and ADGRL3 receptors that are expressed at the surface of adjacent cells. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Postsynaptic cell membrane</location>
            <topology evidence="27">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Presynaptic cell membrane</location>
            <topology evidence="28">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tenascin family. Teneurin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000072060.1">
        <property type="protein sequence ID" value="ENSMODP00000056052.1"/>
        <property type="gene ID" value="ENSMODG00000007437.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234566"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007437">
        <property type="expression patterns" value="Expressed in heart and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000176">
        <property type="entry name" value="Si:ch211-12m10.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000016">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000021">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000026">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000474">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000003">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000013">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000061">
        <property type="entry name" value="teneurin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057627">
        <property type="entry name" value="FN-plug_TEN1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009471">
        <property type="entry name" value="Ten_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056822">
        <property type="entry name" value="TEN_NHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056820">
        <property type="entry name" value="TEN_TTR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057629">
        <property type="entry name" value="Teneurin1-4_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028916">
        <property type="entry name" value="Tox-GHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF8">
        <property type="entry name" value="TENEURIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24329">
        <property type="entry name" value="FN-plug_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23093">
        <property type="entry name" value="GBD_Tenm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06484">
        <property type="entry name" value="Ten_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25021">
        <property type="entry name" value="TEN_NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23538">
        <property type="entry name" value="Teneurin_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15636">
        <property type="entry name" value="Tox-GHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25020">
        <property type="entry name" value="TTR_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51361">
        <property type="entry name" value="TENEURIN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="26" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="21 35" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 35" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="23" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="20 37" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="41" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="18" id="KW-0770">Synapse</keyword>
    <keyword evidence="22" id="KW-0804">Transcription</keyword>
    <keyword evidence="17" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12 37" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 37" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="37">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Teneurin N-terminal" evidence="39">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="38">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="38">
        <location>
            <begin position="685"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="36">
        <location>
            <begin position="53"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="36">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="36">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="36">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="36">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="35">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="35">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="35">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00037805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00046300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00057432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00068165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00077041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00081436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00083964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00093288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="PROSITE" id="PS51361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="2653" mass="294247" checksum="F428E032AFFDC757" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8C6</accession>
    <name>A0A5F8H8C6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8C6"/>
    <dbReference type="Ensembl" id="ENSMODT00000062180.1">
        <property type="protein sequence ID" value="ENSMODP00000056223.1"/>
        <property type="gene ID" value="ENSMODG00000047179.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000047179">
        <property type="expression patterns" value="Expressed in spermatid and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="111"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="198"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="287"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="374"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="463"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="550"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="639"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="726"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="815"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="902"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1074" mass="117667" checksum="12F4EC0DB2A59656" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8C7</accession>
    <name>A0A5F8H8C7_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tower domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000088175.1">
        <property type="protein sequence ID" value="ENSMODP00000055819.1"/>
        <property type="gene ID" value="ENSMODG00000009516.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003602"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000009516">
        <property type="expression patterns" value="Expressed in forelimb bud and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04493">
        <property type="entry name" value="BRCA2DBD_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04494">
        <property type="entry name" value="BRCA2DBD_OB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000205">
        <property type="entry name" value="Breast cancer susceptibility protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048262">
        <property type="entry name" value="BRCA2_OB_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015188">
        <property type="entry name" value="BRCA2_OB_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055077">
        <property type="entry name" value="BRCA2_TR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015205">
        <property type="entry name" value="Tower_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09104">
        <property type="entry name" value="BRCA-2_OB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22687">
        <property type="entry name" value="BRCA2_TR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21318">
        <property type="entry name" value="BRCA2DBD_OB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09121">
        <property type="entry name" value="Tower"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002397">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01341">
        <property type="entry name" value="Tower"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81878">
        <property type="entry name" value="BRCA2 tower domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tower" evidence="8">
        <location>
            <begin position="2750"/>
            <end position="2791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1284"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2348"/>
            <end position="2380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3146"/>
            <end position="3172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3208"/>
            <end position="3231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3262"/>
            <end position="3311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2771"/>
            <end position="2798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1300"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2348"/>
            <end position="2365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="3149"/>
            <end position="3162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="3311" mass="373142" checksum="81E71EF6332CE45C" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8C8</accession>
    <name>A0A5F8H8C8_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil and C2 domain containing 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CC2D2A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000085803.1">
        <property type="protein sequence ID" value="ENSMODP00000056220.1"/>
        <property type="gene ID" value="ENSMODG00000001102.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155482"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001102">
        <property type="expression patterns" value="Expressed in ovary and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028928">
        <property type="entry name" value="CC2D2AN-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041510">
        <property type="entry name" value="DUF5523"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052434">
        <property type="entry name" value="Tectonic-like_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837">
        <property type="entry name" value="CENTROSOMAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837:SF7">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15625">
        <property type="entry name" value="CC2D2AN-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17661">
        <property type="entry name" value="DUF5523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="891"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1493" mass="172662" checksum="A8AE42E487F89C92" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8C9</accession>
    <name>A0A5F8H8C9_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8C9"/>
    <dbReference type="Ensembl" id="ENSMODT00000060520.1">
        <property type="protein sequence ID" value="ENSMODP00000056057.1"/>
        <property type="gene ID" value="ENSMODG00000007681.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159290"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000007681">
        <property type="expression patterns" value="Expressed in spermatocyte and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46478">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46478:SF1">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="288"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="548" mass="62187" checksum="EE99D06B2286A427" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8D0</accession>
    <name>A0A5F8H8D0_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Family with sequence similarity 234 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FAM234A</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAM234 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8D0"/>
    <dbReference type="FunCoup" id="A0A5F8H8D0">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000056228"/>
    <dbReference type="Ensembl" id="ENSMODT00000083166.1">
        <property type="protein sequence ID" value="ENSMODP00000056228.1"/>
        <property type="gene ID" value="ENSMODG00000016651.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063694"/>
    <dbReference type="InParanoid" id="A0A5F8H8D0"/>
    <dbReference type="OMA" id="FMFWGLM"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016651">
        <property type="expression patterns" value="Expressed in spermatocyte and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055409">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419:SF7">
        <property type="entry name" value="PROTEIN FAM234A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23727">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="FAM234A/B beta-propeller" evidence="7">
        <location>
            <begin position="114"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="587" mass="66529" checksum="641B2BAC1FF8ADF7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8D1</accession>
    <name>A0A5F8H8D1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MAP7 domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MAP7D2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAP7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007493509.1">
        <property type="nucleotide sequence ID" value="XM_007493447.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8D1"/>
    <dbReference type="Ensembl" id="ENSMODT00000084758.1">
        <property type="protein sequence ID" value="ENSMODP00000055824.1"/>
        <property type="gene ID" value="ENSMODG00000008158.4"/>
    </dbReference>
    <dbReference type="GeneID" id="100013729"/>
    <dbReference type="CTD" id="256714"/>
    <dbReference type="GeneTree" id="ENSGT00950000182941"/>
    <dbReference type="OrthoDB" id="9950098at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000008158">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008604">
        <property type="entry name" value="MAP7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF3">
        <property type="entry name" value="MAP7 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05672">
        <property type="entry name" value="MAP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="735" mass="83372" checksum="3E6E078291F914D0" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8D3</accession>
    <name>A0A5F8H8D3_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase 2 regulatory subunit B''alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PPP2R3A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007493974.1">
        <property type="nucleotide sequence ID" value="XM_007493912.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8D3"/>
    <dbReference type="Ensembl" id="ENSMODT00000077535.1">
        <property type="protein sequence ID" value="ENSMODP00000056225.1"/>
        <property type="gene ID" value="ENSMODG00000024998.3"/>
    </dbReference>
    <dbReference type="GeneID" id="100016573"/>
    <dbReference type="CTD" id="5523"/>
    <dbReference type="GeneTree" id="ENSGT00940000154659"/>
    <dbReference type="OrthoDB" id="5586at2759"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000024998">
        <property type="expression patterns" value="Expressed in spermatid and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.220:FF:000001">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000628">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.230:FF:000001">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048855">
        <property type="entry name" value="P2R3A_B_D_EF-hand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095">
        <property type="entry name" value="PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21161">
        <property type="entry name" value="P2R3B_EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="482"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="531" mass="61754" checksum="A9D67FA47D4374C8" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8D6</accession>
    <name>A0A5F8H8D6_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pro-neuregulin-2, membrane-bound isoform</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">NRG2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with ERBB3 and ERBB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the neuregulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8D6"/>
    <dbReference type="Ensembl" id="ENSMODT00000083341.1">
        <property type="protein sequence ID" value="ENSMODP00000055829.1"/>
        <property type="gene ID" value="ENSMODG00000011737.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158778"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000011737">
        <property type="expression patterns" value="Expressed in cerebellum and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05750">
        <property type="entry name" value="Ig_Pro_neuregulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000116">
        <property type="entry name" value="pro-neuregulin-2, membrane-bound isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000354">
        <property type="entry name" value="Pro-neuregulin-2, membrane-bound isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040180">
        <property type="entry name" value="Neuregulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002154">
        <property type="entry name" value="Neuregulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057911">
        <property type="entry name" value="NRG2_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11100">
        <property type="entry name" value="HEREGULIN-NEUREGULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11100:SF20">
        <property type="entry name" value="PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02158">
        <property type="entry name" value="Neuregulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="296"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="576"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="621" mass="69091" checksum="A14EEA04FECBAFEE" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8D8</accession>
    <name>A0A5F8H8D8_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC100014763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8D8"/>
    <dbReference type="Ensembl" id="ENSMODT00000066878.1">
        <property type="protein sequence ID" value="ENSMODP00000056238.1"/>
        <property type="gene ID" value="ENSMODG00000048629.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160952"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000048629">
        <property type="expression patterns" value="Expressed in cerebellum and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="137" mass="15582" checksum="16AB2FE9628D8F7A" modified="2019-12-11" version="1">MSKLRPKVVVYPCHQLVAEPKLTFKYFDIFWTNAFGITLTFIPQVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMMGAICAIIVVIIVTAAATAGTRPRGLPQSWMSVLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8D9</accession>
    <name>A0A5F8H8D9_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8D9"/>
    <dbReference type="Ensembl" id="ENSMODT00000072963.1">
        <property type="protein sequence ID" value="ENSMODP00000056235.1"/>
        <property type="gene ID" value="ENSMODG00000041835.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000188864"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="303" mass="30465" checksum="24A6DFDF9FE0341F" modified="2019-12-11" version="1">MRSSCPSPRIRKEPPSCSPVLSCLGGSSWQLDDCPESCCEPSPCCPPASCLTLVCQPVCCMPASCQTCPAVCAPSCCQSTGCGASCCQTCPSAPIQSCCCVPMCCNCCEPCGCSGPSCCPAPCCPPASCLTLVCQPVCCMPASCQPCPAVCAPSCCQSTGCGASCCQTCPSAPIQSCCCVPMCCKPSCCISLPVCCKPSCCVTSACPVLSCSPVPSCCQPPCCQPACSQPLSCRLVCSPATCCVPLSCKPTCCTTSSSSCCCGPSCCCAPSCCHPTSSVSLICRPTCCRPSCCSTSCGQKSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8E1</accession>
    <name>A0A5F8H8E1_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein 366</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dendritic cell-specific transcript protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZNF366</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Has transcriptional repression activity. Acts as a corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with ESR1 and NRIP1. Interacts (via PXDLS motif) with CTBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8E1"/>
    <dbReference type="FunCoup" id="A0A5F8H8E1">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="13616.ENSMODP00000056072"/>
    <dbReference type="Ensembl" id="ENSMODT00000058033.1">
        <property type="protein sequence ID" value="ENSMODP00000056072.1"/>
        <property type="gene ID" value="ENSMODG00000001702.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155498"/>
    <dbReference type="InParanoid" id="A0A5F8H8E1"/>
    <dbReference type="OMA" id="FKHRNKS"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001702">
        <property type="expression patterns" value="Expressed in heart and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033147">
        <property type="term" value="P:negative regulation of intracellular estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043627">
        <property type="term" value="P:response to estrogen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000161">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000182">
        <property type="entry name" value="zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000186">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000191">
        <property type="entry name" value="zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000203">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001180">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001304">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001574">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001721">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000502">
        <property type="entry name" value="Zinc finger protein 710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="152"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="666"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="823" mass="95930" checksum="6949C68C9B69E217" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8E2</accession>
    <name>A0A5F8H8E2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Family with sequence similarity 227 member B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM227 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8E2"/>
    <dbReference type="Ensembl" id="ENSMODT00000082629.1">
        <property type="protein sequence ID" value="ENSMODP00000056243.1"/>
        <property type="gene ID" value="ENSMODG00000002386.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162699"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000002386">
        <property type="expression patterns" value="Expressed in spermatocyte and 17 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029417">
        <property type="entry name" value="FAM227"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33560">
        <property type="entry name" value="PROTEIN FAM227B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33560:SF2">
        <property type="entry name" value="PROTEIN FAM227B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14922">
        <property type="entry name" value="FWWh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="56382" checksum="B52CADC78DF4602E" modified="2019-12-11" version="1">MDKLKEECSFDAIHKHLCEHVPTQHKALLEMEFRLKDLYGDFVEHVTRFLNFPPTPAYSEKEKKLVEIKKMIEKFKKKRILMYPYRTTEKKSIENYTFPGFKANKSTKLPRHLEATEIFLYVLKTQKLERKSFKIWLPLLLSESSIELLKDAFWWWFLHKFKPNQCDQDHLFDRISENYVSFIVRVPNYEKDTFFKLYPDCLSQAIYTIFQEAFPDSSHLFDDEFKEELVTTIFQWVTGVIPPRRVWTRWNLGRLEENTIHGTIKRFIEIEDQKLKCRNLLDKKMEFDLEKLIMDYRNVLLPSPEEPVAKKESHLVGLGPQFCRILFTLGGQSPLVAYYMKVHEIGRNPKLPYSNIQMTQIYQWPATEGQTYNEVITESRKIFAKNKAAHKIFKDKAKQRPEEAMHDCRKYLEKLREVQKKAAISRTPSEVVAGAIASIPYFACLPTLHHHFQEEEEAQEEKKPDDQKSSTFSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8E3</accession>
    <name>A0A5F8H8E3_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Semaphorin-4A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SEMA4A</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8E3"/>
    <dbReference type="Ensembl" id="ENSMODT00000055841.1">
        <property type="protein sequence ID" value="ENSMODP00000055839.1"/>
        <property type="gene ID" value="ENSMODG00000016928.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161509"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000016928">
        <property type="expression patterns" value="Expressed in blood and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001170">
        <property type="entry name" value="Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (Semaphorin) 3F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000019">
        <property type="entry name" value="Semaphorin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000257">
        <property type="entry name" value="semaphorin-4A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF15">
        <property type="entry name" value="SEMAPHORIN-4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="23">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="411"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="568"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00054792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000055839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="611" mass="67333" checksum="D8D5E2E2014F8B4E" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8E4</accession>
    <name>A0A5F8H8E4_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Membrane</location>
            <topology evidence="24">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="Ensembl" id="ENSMODT00000061160.1">
        <property type="protein sequence ID" value="ENSMODP00000056240.1"/>
        <property type="gene ID" value="ENSMODG00000020842.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164144"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000020842">
        <property type="expression patterns" value="Expressed in spermatid and 16 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005021">
        <property type="term" value="F:vascular endothelial growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048010">
        <property type="term" value="P:vascular endothelial growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002412">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002918">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000041">
        <property type="entry name" value="Vascular endothelial growth factor receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000143">
        <property type="entry name" value="Vascular endothelial growth factor receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000247">
        <property type="entry name" value="Vascular endothelial growth factor receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000411">
        <property type="entry name" value="Vascular endothelial growth factor receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001824">
        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041348">
        <property type="entry name" value="VEGFR-2_TMD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055229">
        <property type="entry name" value="VEGFR1-3_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055238">
        <property type="entry name" value="VEGFR1-3_N_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009135">
        <property type="entry name" value="VEGFR1_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF552">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22971">
        <property type="entry name" value="Ig_VEGFR-1-like_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21339">
        <property type="entry name" value="VEGFR-1-like_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17988">
        <property type="entry name" value="VEGFR-2_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22854">
        <property type="entry name" value="VEGFR1-3_N_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01832">
        <property type="entry name" value="VEGFRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01833">
        <property type="entry name" value="VEGFRECEPTR1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00240">
        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="14 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0221">Differentiation</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="21 24" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19 24" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="439"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="567"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="647"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="774"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="874"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="1039"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1179"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1399"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1487"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="1193"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1426"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="1073"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1544" mass="170975" checksum="B80227909502E0E5" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8E7</accession>
    <name>A0A5F8H8E7_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 88A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC88A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSMODT00000080999.1">
        <property type="protein sequence ID" value="ENSMODP00000056245.1"/>
        <property type="gene ID" value="ENSMODG00000001885.5"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155559"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000001885">
        <property type="expression patterns" value="Expressed in spermatocyte and 20 other cell types or tissues"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF30">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1373"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1446"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="774"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1229"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1402"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1446"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1458"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1475"/>
            <end position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="1662" mass="191281" checksum="ED16AB1A94DD59E7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8F0</accession>
    <name>A0A5F8H8F0_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">FAT atypical cadherin 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMODT00000082985.1">
        <property type="protein sequence ID" value="ENSMODP00000056253.1"/>
        <property type="gene ID" value="ENSMODG00000005018.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157733"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000005018">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 19 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000013">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000152">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000154">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000179">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000021">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000026">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000032">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000037">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000051">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000052">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000064">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000065">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000067">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000075">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000079">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000089">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000107">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000161">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000053">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000058">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000059">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000061">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000084">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000057">
        <property type="entry name" value="protocadherin Fat 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000035">
        <property type="entry name" value="Protocadherin Fat 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023891485" description="FAT atypical cadherin 1" evidence="16">
        <location>
            <begin position="23"/>
            <end position="4498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="4093"/>
            <end position="4113"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="151"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="369"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="465"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="578"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="719"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="824"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="929"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1097"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1203"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1383"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1473"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1578"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1676"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1790"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1890"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="1992"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2093"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2194"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2302"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2404"/>
            <end position="2507"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2508"/>
            <end position="2614"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2615"/>
            <end position="2720"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2721"/>
            <end position="2829"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2830"/>
            <end position="2934"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="2935"/>
            <end position="3036"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="3037"/>
            <end position="3141"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="3142"/>
            <end position="3246"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="3247"/>
            <end position="3351"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="3352"/>
            <end position="3456"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="3472"/>
            <end position="3558"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3701"/>
            <end position="3738"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="3740"/>
            <end position="3920"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3924"/>
            <end position="3961"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3963"/>
            <end position="3999"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="4000"/>
            <end position="4036"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="4038"/>
            <end position="4074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4167"/>
            <end position="4191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4215"/>
            <end position="4238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4325"/>
            <end position="4389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4405"/>
            <end position="4427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4474"/>
            <end position="4498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="4167"/>
            <end position="4176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="4345"/>
            <end position="4363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="4411"/>
            <end position="4422"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="3710"/>
            <end position="3727"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="3951"/>
            <end position="3960"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="3989"/>
            <end position="3998"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="4026"/>
            <end position="4035"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="4064"/>
            <end position="4073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4498" mass="498960" checksum="BA99844FDE8332F7" modified="2019-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8F1</accession>
    <name>A0A5F8H8F1_MONDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">APC regulator of WNT signaling pathway</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">APC</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person name="Gearin C.R."/>
                <person name="Giannoukos G."/>
                <person name="Goode T."/>
                <person name="Graham J."/>
                <person name="Grandbois E."/>
                <person name="Grewal S."/>
                <person name="Gyaltsen K."/>
                <person name="Hafez N."/>
                <person name="Hagos B."/>
                <person name="Hall J."/>
                <person name="Henson C."/>
                <person name="Hollinger A."/>
                <person name="Honan T."/>
                <person name="Huard M.D."/>
                <person name="Hughes L."/>
                <person name="Hurhula B."/>
                <person name="Husby M.E."/>
                <person name="Kamat A."/>
                <person name="Kanga B."/>
                <person name="Kashin S."/>
                <person name="Khazanovich D."/>
                <person name="Kisner P."/>
                <person name="Lance K."/>
                <person name="Lara M."/>
                <person name="Lee W."/>
                <person name="Lennon N."/>
                <person name="Letendre F."/>
                <person name="LeVine R."/>
                <person name="Lipovsky A."/>
                <person name="Liu X."/>
                <person name="Liu J."/>
                <person name="Liu S."/>
                <person name="Lokyitsang T."/>
                <person name="Lokyitsang Y."/>
                <person name="Lubonja R."/>
                <person name="Lui A."/>
                <person name="MacDonald P."/>
                <person name="Magnisalis V."/>
                <person name="Maru K."/>
                <person name="Matthews C."/>
                <person name="McCusker W."/>
                <person name="McDonough S."/>
                <person name="Mehta T."/>
                <person name="Meldrim J."/>
                <person name="Meneus L."/>
                <person name="Mihai O."/>
                <person name="Mihalev A."/>
                <person name="Mihova T."/>
                <person name="Mittelman R."/>
                <person name="Mlenga V."/>
                <person name="Montmayeur A."/>
                <person name="Mulrain L."/>
                <person name="Navidi A."/>
                <person name="Naylor J."/>
                <person name="Negash T."/>
                <person name="Nguyen T."/>
                <person name="Nguyen N."/>
                <person name="Nicol R."/>
                <person name="Norbu C."/>
                <person name="Norbu N."/>
                <person name="Novod N."/>
                <person name="O'Neill B."/>
                <person name="Osman S."/>
                <person name="Markiewicz E."/>
                <person name="Oyono O.L."/>
                <person name="Patti C."/>
                <person name="Phunkhang P."/>
                <person name="Pierre F."/>
                <person name="Priest M."/>
                <person name="Raghuraman S."/>
                <person name="Rege F."/>
                <person name="Reyes R."/>
                <person name="Rise C."/>
                <person name="Rogov P."/>
                <person name="Ross K."/>
                <person name="Ryan E."/>
                <person name="Settipalli S."/>
                <person name="Shea T."/>
                <person name="Sherpa N."/>
                <person name="Shi L."/>
                <person name="Shih D."/>
                <person name="Sparrow T."/>
                <person name="Spaulding J."/>
                <person name="Stalker J."/>
                <person name="Stange-Thomann N."/>
                <person name="Stavropoulos S."/>
                <person name="Stone C."/>
                <person name="Strader C."/>
                <person name="Tesfaye S."/>
                <person name="Thomson T."/>
                <person name="Thoulutsang Y."/>
                <person name="Thoulutsang D."/>
                <person name="Topham K."/>
                <person name="Topping I."/>
                <person name="Tsamla T."/>
                <person name="Vassiliev H."/>
                <person name="Vo A."/>
                <person name="Wangchuk T."/>
                <person name="Wangdi T."/>
                <person name="Weiand M."/>
                <person name="Wilkinson J."/>
                <person name="Wilson A."/>
                <person name="Yadav S."/>
                <person name="Young G."/>
                <person name="Yu Q."/>
                <person name="Zembek L."/>
                <person name="Zhong D."/>
                <person name="Zimmer A."/>
                <person name="Zwirko Z."/>
                <person name="Jaffe D.B."/>
                <person name="Alvarez P."/>
                <person name="Brockman W."/>
                <person name="Butler J."/>
                <person name="Chin C."/>
                <person name="Gnerre S."/>
                <person name="MacCallum I."/>
                <person name="Graves J.A."/>
                <person name="Ponting C.P."/>
                <person name="Breen M."/>
                <person name="Samollow P.B."/>
                <person name="Lander E.S."/>
                <person name="Lindblad-Toh K."/>
            </authorList>
            <dbReference type="PubMed" id="17495919"/>
            <dbReference type="DOI" id="10.1038/nature05805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A5F8H8F1"/>
    <dbReference type="Ensembl" id="ENSMODT00000068262.1">
        <property type="protein sequence ID" value="ENSMODP00000056250.1"/>
        <property type="gene ID" value="ENSMODG00000013281.4"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063749"/>
    <dbReference type="Proteomes" id="UP000002280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMODG00000013281">
        <property type="expression patterns" value="Expressed in spinal cord and 18 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.450:FF:000001">
        <property type="entry name" value="adenomatous polyposis coli protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.10:FF:000002">
        <property type="entry name" value="adenomatous polyposis coli protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.450">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026831">
        <property type="entry name" value="APC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026818">
        <property type="entry name" value="Apc_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032038">
        <property type="entry name" value="APC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036149">
        <property type="entry name" value="APC_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607:SF11">
        <property type="entry name" value="ADENOMATOUS POLYPOSIS COLI PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607">
        <property type="entry name" value="ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16689">
        <property type="entry name" value="APC_N_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11414">
        <property type="entry name" value="Suppressor_APC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58050">
        <property type="entry name" value="N-terminal coiled coil domain from apc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82931">
        <property type="entry name" value="Tumor suppressor gene product Apc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenomatous polyposis coli N-terminal dimerisation" evidence="2">
        <location>
            <begin position="98"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMODP00000056250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002280"/>
        </source>
    </evidence>
    <sequence length="355" mass="40266" checksum="8A1E1D9E5C10A204" modified="2019-12-11" version="1">MVRHPFWGCGRPVLWGGVSAFRGRLLWKGQGQQRGNLLIAAPSSSLLGGELGDWLAELPRDRHVAALAQPRRGCHWRWNGGAARFGDGVEGEPRMAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRPKMSIRSYGSREGSVSSRSGECSPVPMGSFSRRGFMNGSRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRAAMEEQLGTCQDMEKRAQLRVARIQQIEKDILRIRQLLQSQPAEAEILEEFGNSFSSSFCRLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5F8H8F2</accession>
    <name>A0A5F8H8F2_MONDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transmembrane protein 267</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Monodelphis domestica</name>
        <name type="common">Gray short-tailed opossum</name>
        <dbReference type="NCBI Taxonomy" id="13616"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Metatheria</taxon>
            <taxon>Didelphimorphia</taxon>
            <taxon>Didelphidae</taxon>
            <taxon>Monodelphis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Nature" volume="447" first="167" last="177">
            <title>Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.</title>
            <authorList>
                <person name="Mikkelsen T.S."/>
                <person name="Wakefield M.J."/>
                <person name="Aken B."/>
                <person name="Amemiya C.T."/>
                <person name="Chang J.L."/>
                <person name="Duke S."/>
                <person name="Garber M."/>
                <person name="Gentles A.J."/>
                <person name="Goodstadt L."/>
                <person name="Heger A."/>
                <person name="Jurka J."/>
                <person name="Kamal M."/>
                <person name="Mauceli E."/>
                <person name="Searle S.M."/>
                <person name="Sharpe T."/>
                <person name="Baker M.L."/>
                <person name="Batzer M.A."/>
                <person name="Benos P.V."/>
                <person name="Belov K."/>
                <person name="Clamp M."/>
                <person name="Cook A."/>
                <person name="Cuff J."/>
                <person name="Das R."/>
                <person name="Davidow L."/>
                <person name="Deakin J.E."/>
                <person name="Fazzari M.J."/>
                <person name="Glass J.L."/>
                <person name="Grabherr M."/>
                <person name="Greally J.M."/>
                <person name="Gu W."/>
                <person name="Hore T.A."/>
                <person name="Huttley G.A."/>
                <person name="Kleber M."/>
                <person name="Jirtle R.L."/>
                <person name="Koina E."/>
                <person name="Lee J.T."/>
                <person name="Mahony S."/>
                <person name="Marra M.A."/>
                <person name="Miller R.D."/>
                <person name="Nicholls R.D."/>
                <person name="Oda M."/>
                <person name="Papenfuss A.T."/>
                <person name="Parra Z.E."/>
                <person name="Pollock D.D."/>
                <person name="Ray D.A."/>
                <person name="Schein J.E."/>
                <person name="Speed T.P."/>
                <person name="Thompson K."/>
                <person name="VandeBerg J.L."/>
                <person name="Wade C.M."/>
                <person name="Walker J.A."/>
                <person name="Waters P.D."/>
                <person name="Webber C."/>
                <person name="Weidman J.R."/>
                <person name="Xie X."/>
                <person name="Zody M.C."/>
                <person name="Baldwin J."/>
                <person name="Abdouelleil A."/>
                <person name="Abdulkadir J."/>
                <person name="Abebe A."/>
                <person name="Abera B."/>
                <person name="Abreu J."/>
                <person name="Acer S.C."/>
                <person name="Aftuck L."/>
                <person name="Alexander A."/>
                <person name="An P."/>
                <person name="Anderson E."/>
                <person name="Anderson S."/>
                <person name="Arachi H."/>
                <person name="Azer M."/>
                <person name="Bachantsang P."/>
                <person name="Barry A."/>
                <person name="Bayul T."/>
                <person name="Berlin A."/>
                <person name="Bessette D."/>
                <person name="Bloom T."/>
                <person name="Bloom T."/>
                <person name="Boguslavskiy L."/>
                <person name="Bonnet C."/>
                <person name="Boukhgalter B."/>
                <person name="Bourzgui I."/>
                <person name="Brown A."/>
                <person name="Cahill P."/>
                <person name="Channer S."/>
                <person name="Cheshatsang Y."/>
                <person name="Chuda L."/>
                <person name="Citroen M."/>
                <person name="Collymore A."/>
                <person name="Cooke P."/>
                <person name="Costello M."/>
                <person name="D'Aco K."/>
                <person name="Daza R."/>
                <person name="De Haan G."/>
                <person name="DeGray S."/>
                <person name="DeMaso C."/>
                <person name="Dhargay N."/>
                <person name="Dooley K."/>
                <person name="Dooley E."/>
                <person name="Doricent M."/>
                <person name="Dorje P."/>
                <person name="Dorjee K."/>
                <person name="Dupes A."/>
                <person name="Elong R."/>
                <person name="Falk J."/>
                <person name="Farina A."/>
                <person name="Faro S."/>
                <person name="Ferguson D."/>
                <person name="Fisher S."/>
                <person name="Foley C.D."/>
                <person name="Franke A."/>
                <person name="Friedrich D."/>
                <person name="Gadbois L."/>
                <person name="Gearin G."/>
                <person